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Dr Yan Liu is a lecturer of in Glycosciences in the Faculty of Medicine at Imperial College London. Originally trained as a Carbohydrate Chemist, her career has been largely centred on the development and applications of glycan microarrays to elucidate glycan recognition events of biomedical importance. Her most significant achievement to date is the setting up, with Professor Feizi and colleagues in the Glycoscience Laboratory, the Carbohydrate Microarray Facility which has become a unique international collaborative resource for the broad scientific community. She is the PI of the 4-year Wellcome Trust Biomedical Resource Grant entitled 'Carbohydrate Microarray Facility for the New Era of Glycomics' (Nov 2019-Oct 2023), and a key focus of her current research is to develop novel glyco-based diagnostic, therapeutic and management strategies to combat infectious and non-infectious diseases. Collaboration has been at the heart of her research. Over the last 15 years she has coordinated projects on glycan recognition by proteins and pathogens with over 120 researchers in the UK and abroad and has over 71 research publications (Google Scholar: h-index 38). With collaborators in complementary fields (virology, parasitology, protein expression and crystallography), she has applied glycan microarrays in elucidation of the glycan binding specificities of a wide range of adhesive proteins of viruses (polyoma, papilloma, dengue, adenoviruses, rotaviruses and noroviruses), bacteria (Salmonella typhimurium, Streptococcus pneumoniae), parasites (Toxoplasma gondii and related apicomplexans, e.g. Eimeria tenella), as well as whole viruses (influenza, papilloma and Chikungunya). My contributions to glycan recognition in pathogen-host interactions are evidenced by 34 research publications in this area. Since April 2018, Dr Liu is a co-investigator in the 5-year Imperial College-March of Dimes European Preterm Birth Research Centre programme. In collaboration with colleagues in the Glycosciences Laboratory, she has established a methodology for microarray analyses of fluorescently labelled whole bacterial cells. This has broaden the scope of her studies in glycan mediated bacteria-host interactions. Dr Liu is actively contributing to the development of the international glycan microarray data repository in the NIH GlyGen project and is working towards the development of a novel curated Glyco-interactome resource for the broad biology community. Dr Liu has been supervising Master research students and currently has three PhD students at Imperial College London (main supervisor for two of the students). She is the oversea co-supervisor for Filipa Trovão, a joint PhD student with Angelina Sá Palma, Ana Luísa Carvalho (UCIBIO-NOVA, Lisbon; Jan 2020-Dec 2023) on a project entitled Translating the human-microbiome molecular cross-talk using glycan microarray and structural biology strategies¿, supported by FCT PhD fellowship. --------------------------------------------------------------------------------- Link to the full list of publications: http://www.imperial.ac.uk/people/yan.liu2/publications.html Link to the Carbohydrate Microarray Facility: https://www.imperial.ac.uk/glycosciences/carbohydrate-microarray- facility/
Identificação

Identificação pessoal

Nome completo
Yan Liu

Nomes de citação

  • Liu, Yan

Identificadores de autor

Ciência ID
0119-25D3-25FE
ORCID iD
0000-0002-2566-6867

Websites

Domínios de atuação

  • Ciências Exatas - Química
Formação
Grau Classificação
2001 - 2005
Concluído
Organic Chemistry (Doctor of Philosophy)
University of Bristol School of Chemistry, Reino Unido
1997 - 2001
Concluído
Chemistry (Bachelor)
Peking University College of Chemistry and Molecular Engineering, China
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/03/01 - Atual Investigador principal (carreira) (Investigação) Imperial College London Faculty of Medicine, Reino Unido
Imperial College London Faculty of Medicine, Reino Unido
2018 - Atual Investigador Coordenador (carreira) (Investigação) Imperial College London Department of Surgery and Cancer, Reino Unido
2013 - 2018 Investigador Coordenador (carreira) (Investigação) Imperial College London Glycosciences Laboratory, Reino Unido
2008 - 2012 Investigador Contratado (Investigação) Imperial College London Glycosciences Laboratory, Reino Unido
2005 - 2008 Pós-doutorado (Investigação) Imperial College London Glycosciences Laboratory, Reino Unido
Projetos

Bolsa

Designação Financiadores
2019/11 - 2023/10 Carbohydrate Microarray Facility for the New Era of Glycomics Wellcome Trust
2018/04 - 2023/03 The Imperial College-March of Dimes European Prematurity Research Center
WSCR P76171
March of Dimes Foundation
2019 - 2023 Carbohydrate Microarray Facility for the New Era of Glycomics
099197
Investigador responsável
Wellcome Trust
Em curso
2018 - 2023 The Imperial College-March of Dimes European Prematurity Research Center
22-FY18-82
Bolseiro de Integração na Investigação
March of Dimes Foundation
Em curso
2015/08 - 2017/09 Carbohydrate Microarray Facility for Biomedical Exploitation
108430/Z/15/Z
Wellcome Trust
2013/08/01 - 2017 Carbohydrate Microarray Facility for Biomedical Exploitation
info:eu-repo/grantAgreement/WT/Immune System in Health and Disease/108430/
Wellcome Trust
2012/08 - 2015/07 “Carbohydrate Microarray Facility for Biomedical Exploitation”
099197/Z/12/Z
Wellcome Trust
Produções

Publicações

Artigo em revista
  1. "Mapping Molecular Recognition of ß1,3-1,4-Glucans by a Surface Glycan-Binding Protein from the Human Gut Symbiont Bacteroides ovatus.". Microbiology spectrum (2021): https://europepmc.org/articles/PMC8612152.
    10.1128/spectrum.01826-21
  2. "Editorial: Glycans as Players in Host-Microbe Interactions: A Structural Perspective.". Frontiers in molecular biosciences (2021): https://europepmc.org/articles/PMC8595467.
    10.3389/fmolb.2021.791765
  3. Frederick Gyapon-Quast; Elena Goicoechea de Jorge; Talat Malik; Nian Wu; Jin Yu; Wengang Chai; Ten Feizi; Yan Liu; Matthew C. Pickering. "Defining the Glycosaminoglycan Interactions of Complement Factor H–Related Protein 5". The Journal of Immunology 207 2 (2021): 534-541. https://doi.org/10.4049/jimmunol.2000072.
    10.4049/jimmunol.2000072
  4. "Chikungunya Virus Strains from Each Genetic Clade Bind Sulfated Glycosaminoglycans as Attachment Factors.". Journal of virology (2020): https://europepmc.org/articles/PMC7925169.
    10.1128/jvi.01500-20
  5. Ingrida Vendele; Tobias M. Hohl; Janet A. Willment; Lisete M. Silva; Angelina S. Palma; Wengang Chai; Yan Liu; et al. "Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls". PLOS Pathogens 16 1 (2020): e1007927-e1007927. https://doi.org/10.1371/journal.ppat.1007927.
    10.1371/journal.ppat.1007927
  6. Wu, Nian; Silva, Lisete M.; Liu, Yan; Zhang, Yibing; Gao, Chao; Zhang, Fuming; Fu, Li; et al. "Glycan Markers of Human Stem Cells Assigned with Beam Search Arrays". Molecular & Cellular Proteomics 18 10 (2019): 1981-2002. http://dx.doi.org/10.1074/mcp.ra119.001309.
    10.1074/mcp.ra119.001309
  7. Chandra, Naresh; Liu, Yan; Liu, Jing-Xia; Frängsmyr, Lars; Wu, Nian; Silva, Lisete; Lindström, Mona; et al. "Sulfated Glycosaminoglycans as Viral Decoy Receptors for Human Adenovirus Type 37". Viruses 11 3 (2019): 247. http://dx.doi.org/10.3390/v11030247.
    10.3390/v11030247
  8. Lenman, Annasara; Liaci, A. Manuel; Liu, Yan; Frängsmyr, Lars; Frank, Martin; Blaum, Bärbel S.; Chai, Wengang; et al. "Polysialic acid is a cellular receptor for human adenovirus 52". Proceedings of the National Academy of Sciences 115 18 (2018): E4264-E4273. http://dx.doi.org/10.1073/pnas.1716900115.
    10.1073/pnas.1716900115
  9. Stappers, Mark H. T.; Clark, Alexandra E.; Aimanianda, Vishukumar; Bidula, Stefan; Reid, Delyth M.; Asamaphan, Patawee; Hardison, Sarah E.; et al. "Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus". Nature 555 7696 (2018): 382-386. http://dx.doi.org/10.1038/nature25974.
    10.1038/nature25974
  10. Li, Zhen; Gao, Chao; Zhang, Yibing; Palma, Angelina S.; Childs, Robert A.; Silva, Lisete M.; Liu, Yang; et al. "O-Glycome Beam Search Arrays for Carbohydrate Ligand Discovery". Molecular & Cellular Proteomics 17 1 (2017): 121-133. http://dx.doi.org/10.1074/mcp.ra117.000285.
    10.1074/mcp.ra117.000285
  11. Liu, Yan; McBride, Ryan; Stoll, Mark; Palma, Angelina S; Silva, Lisete; Agravat, Sanjay; Aoki-Kinoshita, Kiyoko F; et al. "The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data". Glycobiology (2016): http://dx.doi.org/10.1093/glycob/cww118.
    10.1093/glycob/cww118
  12. Bartels, Markus F.; Winterhalter, Patrick R.; Yu, Jin; Liu, Yan; Lommel, Mark; Möhrlen, Frank; Hu, Huaiyu; et al. "Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates". PLOS ONE 11 11 (2016): e0166119. http://dx.doi.org/10.1371/journal.pone.0166119.
    10.1371/journal.pone.0166119
  13. Liu, Yang; Ramelot, Theresa A.; Huang, Pengwei; Liu, Yan; Li, Zhen; Feizi, Ten; Zhong, Weiming; et al. "Glycan Specificity of P[19] Rotavirus and Comparison with Those of Related P Genotypes". Journal of Virology 90 21 (2016): 9983-9996. http://dx.doi.org/10.1128/jvi.01494-16.
    10.1128/jvi.01494-16
  14. Parker, Lauren; Wharton, Stephen A.; Martin, Stephen R.; Cross, Karen; Lin, Yipu; Liu, Yan; Feizi, Ten; Daniels, Rodney S.; McCauley, John W.. "Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses". Journal of General Virology 97 6 (2016): 1333-1344. http://dx.doi.org/10.1099/jgv.0.000457.
    10.1099/jgv.0.000457
  15. Zhang, Hongtao; Palma, Angelina S; Zhang, Yibing; Childs, Robert A; Liu, Yan; Mitchell, Daniel A; Guidolin, Leticia S; et al. "Generation and characterization of ß1,2-gluco-oligosaccharide probes fromBrucella abortuscyclic ß-glucan and their recognition by C-type lectins of the immune system". Glycobiology 26 10 (2016): 1086-1096. http://dx.doi.org/10.1093/glycob/cww041.
    10.1093/glycob/cww041
  16. Cecílio, Nerry Tatiana; Carvalho, Fernanda Caroline; Liu, Yan; Moncrieffe, Martin; Buranello, Patrícia Andressa de Almeida; Zorzetto-Fernandes, Andre Luiz; Luche, Douglas Dalle; et al. "Yeast expressed ArtinM shares structure, carbohydrate recognition, and biological effects with native ArtinM". International Journal of Biological Macromolecules 82 (2016): 22-30. http://dx.doi.org/10.1016/j.ijbiomac.2015.09.062.
    10.1016/j.ijbiomac.2015.09.062
  17. Liu, Y.; Cecílio, N.T.; Carvalho, F.C.; Roque-Barreira, M.C.; Feizi, T.. "Glycan microarray analysis of the carbohydrate-recognition specificity of native and recombinant forms of the lectin ArtinM". Data in Brief 5 (2015): 1035-1047. http://dx.doi.org/10.1016/j.dib.2015.11.014.
    10.1016/j.dib.2015.11.014
  18. Gao, Chao; Zhang, Yibing; Liu, Yan; Feizi, Ten; Chai, Wengang. "Negative-Ion Electrospray Tandem Mass Spectrometry and Microarray Analyses of Developmentally Regulated Antigens Based on Type 1 and Type 2 Backbone Sequences". Analytical Chemistry 87 23 (2015): 11871-11878. http://dx.doi.org/10.1021/acs.analchem.5b03471.
    10.1021/acs.analchem.5b03471
  19. Hanashima, Shinya; Götze, Sebastian; Liu, Yan; Ikeda, Akemi; Kojima-Aikawa, Kyoko; Taniguchi, Naoyuki; Varón Silva, Daniel; et al. "Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides". ChemBioChem 16 10 (2015): 1502-1511. http://dx.doi.org/10.1002/cbic.201500103.
    10.1002/cbic.201500103
  20. Kakugawa, Satoshi; Langton, Paul F.; Zebisch, Matthias; Howell, Steven A.; Chang, Tao-Hsin; Liu, Yan; Feizi, Ten; et al. "Notum deacylates Wnt proteins to suppress signalling activity". Nature 519 7542 (2015): 187-192. http://dx.doi.org/10.1038/nature14259.
    10.1038/nature14259
  21. Lenman, Annasara; Liaci, A. Manuel; Liu, Yan; Årdahl, Carin; Rajan, Anandi; Nilsson, Emma; Bradford, Will; et al. "Human Adenovirus 52 Uses Sialic Acid-containing Glycoproteins and the Coxsackie and Adenovirus Receptor for Binding to Target Cells". PLOS Pathogens 11 2 (2015): e1004657. http://dx.doi.org/10.1371/journal.ppat.1004657.
    10.1371/journal.ppat.1004657
  22. Palma, Angelina S.; Liu, Yan; Zhang, Hongtao; Zhang, Yibing; McCleary, Barry V.; Yu, Guangli; Huang, Qilin; et al. "Unravelling Glucan Recognition Systems by Glycome Microarrays Using the Designer Approach and Mass Spectrometry". Molecular & Cellular Proteomics 14 4 (2015): 974-988. http://dx.doi.org/10.1074/mcp.m115.048272.
    10.1074/mcp.m115.048272
  23. Falkowska, Emilia; Le, Khoa M.; Ramos, Alejandra; Doores, Katie J.; Lee, Jeong Hyun; Blattner, Claudia; Ramirez, Alejandro; et al. "Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers". Immunity 40 5 (2014): 657-668. http://dx.doi.org/10.1016/j.immuni.2014.04.009.
    10.1016/j.immuni.2014.04.009
  24. Kanagawa, Mayumi; Liu, Yan; Hanashima, Shinya; Ikeda, Akemi; Chai, Wengang; Nakano, Yukiko; Kojima-Aikawa, Kyoko; Feizi, Ten; Yamaguchi, Yoshiki. "Structural Basis for Multiple Sugar Recognition of Jacalin-related Human ZG16p Lectin". Journal of Biological Chemistry 289 24 (2014): 16954-16965. http://dx.doi.org/10.1074/jbc.m113.539114.
    10.1074/jbc.m113.539114
  25. Gao, Chao; Liu, Yan; Zhang, Hongtao; Zhang, Yibing; Fukuda, Michiko N.; Palma, Angelina S.; Kozak, Radoslaw P.; et al. "Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a MucinO-Glycome Designer Array". Journal of Biological Chemistry 289 23 (2014): 16462-16477. http://dx.doi.org/10.1074/jbc.m114.558932.
    10.1074/jbc.m114.558932
  26. York, W. S.; Agravat, S.; Aoki-Kinoshita, K. F.; McBride, R.; Campbell, M. P.; Costello, C. E.; Dell, A.; et al. "MIRAGE: The minimum information required for a glycomics experiment". Glycobiology 24 5 (2014): 402-406. http://dx.doi.org/10.1093/glycob/cwu018.
    10.1093/glycob/cwu018
  27. Khan, Z. M.; Liu, Y.; Neu, U.; Gilbert, M.; Ehlers, B.; Feizi, T.; Stehle, T.. "Crystallographic and Glycan Microarray Analysis of Human Polyomavirus 9 VP1 Identifies N-Glycolyl Neuraminic Acid as a Receptor Candidate". Journal of Virology 88 11 (2014): 6100-6111. http://dx.doi.org/10.1128/jvi.03455-13.
    10.1128/jvi.03455-13
  28. Palma, Angelina S; Feizi, Ten; Childs, Robert A; Chai, Wengang; Liu, Yan. "The neoglycolipid (NGL)-based oligosaccharide microarray system poised to decipher the meta-glycome". Current Opinion in Chemical Biology 18 (2014): 87-94. http://dx.doi.org/10.1016/j.cbpa.2014.01.007.
    10.1016/j.cbpa.2014.01.007
  29. Crusat, Martin; Liu, Junfeng; Palma, Angelina S.; Childs, Robert A.; Liu, Yan; Wharton, Stephen A.; Lin, Yi Pu; et al. "Changes in the hemagglutinin of H5N1 viruses during human infection – Influence on receptor binding". Virology 447 1-2 (2013): 326-337. http://dx.doi.org/10.1016/j.virol.2013.08.010.
    10.1016/j.virol.2013.08.010
  30. Neu, Ursula; Khan, Zaigham Mahmood; Schuch, Benjamin; Palma, Angelina S.; Liu, Yan; Pawlita, Michael; Feizi, Ten; Stehle, Thilo. "Structures of B-Lymphotropic Polyomavirus VP1 in Complex with Oligosaccharide Ligands". PLoS Pathogens 9 10 (2013): e1003714. http://dx.doi.org/10.1371/journal.ppat.1003714.
    10.1371/journal.ppat.1003714
  31. Neu, Ursula; Allen, Stacy-ann A.; Blaum, Bärbel S.; Liu, Yan; Frank, Martin; Palma, Angelina S.; Ströh, Luisa J.; et al. "A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus". PLoS Pathogens 9 10 (2013): e1003688. http://dx.doi.org/10.1371/journal.ppat.1003688.
    10.1371/journal.ppat.1003688
  32. Kong, Leopold; Lee, Jeong Hyun; Doores, Katie J; Murin, Charles D; Julien, Jean-Philippe; McBride, Ryan; Liu, Yan; et al. "Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120". Nature Structural & Molecular Biology 20 7 (2013): 796-803. http://dx.doi.org/10.1038/nsmb.2594.
    10.1038/nsmb.2594
  33. Reiss, Kerstin; Stencel, Jennifer E.; Liu, Yan; Blaum, Bärbel S.; Reiter, Dirk M.; Feizi, Ten; Dermody, Terence S.; Stehle, Thilo. "The GM2 Glycan Serves as a Functional Coreceptor for Serotype 1 Reovirus". PLoS Pathogens 8 12 (2012): e1003078. http://dx.doi.org/10.1371/journal.ppat.1003078.
    10.1371/journal.ppat.1003078
  34. Mouquet, H.; Scharf, L.; Euler, Z.; Liu, Y.; Eden, C.; Scheid, J. F.; Halper-Stromberg, A.; et al. "Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies". Proceedings of the National Academy of Sciences 109 47 (2012): E3268-E3277. http://dx.doi.org/10.1073/pnas.1217207109.
    10.1073/pnas.1217207109
Capítulo de livro
  1. Liu, Yan; Palma, Angelina S.; Feizi, Ten; Chai, Wengang. "Insights Into Glucan Polysaccharide Recognition Using Glucooligosaccharide Microarrays With Oxime-Linked Neoglycolipid Probes". In Chemical Glycobiology Part B. Monitoring Glycans and their Interactions, 139-167. Elsevier, 2018.
    10.1016/bs.mie.2017.09.001
  2. Liu, Yan; Childs, Robert A.; Feizi, Ten. "Neoglycolipid (NGL)-Based Glycan Microarray System for Ligand Discovery". In Glycoscience: Biology and Medicine, 25-34. Springer Japan, 2014.
    10.1007/978-4-431-54841-6_88
  3. Liu, Yan; Childs, Robert A.; Feizi, Ten. "Neoglycolipid (NGL)-Based Glycan Microarray System for Ligand Discovery". In Glycoscience: Biology and Medicine, 1-9. Springer Japan, 2014.
    10.1007/978-4-431-54836-2_88-2
  4. Liu, Yan; Childs, Robert A.; Palma, Angelina S.; Campanero-Rhodes, Maria A.; Stoll, Mark S.; Chai, Wengang; Feizi, Ten. "Neoglycolipid-Based Oligosaccharide Microarray System: Preparation of NGLs and Their Noncovalent Immobilization on Nitrocellulose-Coated Glass Slides for Microarray Analyses". In Methods in Molecular Biology, 117-136. Humana Press, 2011.
    10.1007/978-1-61779-373-8_8
  5. Palma, Angelina S.; Zhang, Yibing; Childs, Robert A.; Campanero-Rhodes, Maria A.; Liu, Yan; Feizi, Ten; Chai, Wengang. "Neoglycolipid-Based “Designer” Oligosaccharide Microarrays to Define ß-Glucan Ligands for Dectin-1". In Methods in Molecular Biology, 337-359. Humana Press, 2011.
    10.1007/978-1-61779-373-8_23
  6. Liu, Yan; Feizi, Ten. "Microarrays – A Key Technology for Glycobiology". In Glycoscience, 2121-2132. Springer Berlin Heidelberg, 2008.
    10.1007/978-3-540-30429-6_54

Outros

Outra produção
  1. Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls. 2019. Ingrida Vendele; Janet A. Willment; Lisete M. Silva; Angelina S. Palma; Wengang Chai; Yan Liu; Ten Feizi; et al. https://doi.org/10.1101/677104.
    10.1101/677104
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2021/11 - 2025/10 Synthetic lipo-glycopeptides to explore the epitope space of antiviral neutralizing antibodies
Coorientador
Imperial College London, Reino Unido
2020/11 - 2024/10 High Precision Glycosaminoglycome¿ Microarrays for Probing Microbe-Host Interactions
Orientador
Imperial College London, Reino Unido
2020/11 - 2024/10 The role of glycans in cytomegalovirus (CMV) and extracellular vesicle (EV) uptake by the placenta
Coorientador
Imperial College London, Reino Unido
2020/01 - 2023/12 Translating the human-microbiome molecular cross-talk using glycan microarray and structural biology strategies
Coorientador
Distinções

Prémio

2010 Imperial College Center for Respiratory Infection Director Award
Imperial College London, Reino Unido
2008 The Wellcome Trust Value in People Award