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I am a cell and molecular biologist with more than 15 years’ experience in the field of biology of aging and direct the Cell and Molecular Aging laboratory at Mayo Clinic. I have led an independent research program focused on cellular senescence and mechanisms of aging since 2010, firstly at the Newcastle University Institute for Ageing in the UK and since 2018 at Mayo Clinic, US. My laboratory has been continuously funded by several UK, US and European funding bodies since its inception. I have therefore directed various projects, which have resulted in several significant publications and trained several PhD students and post-doctoral fellows. My research is focused on investigating the role of senescent cells in aging and age-related disease, with a particular focus on mitochondria and telomeres. Research focus areas involve cellular senescence, telomeres and mitochondrial biology. My laboratory has made several important contributions to the understanding of the mechanisms underlying mitochondrial dysfunction during senescence. We have shown that dysfunctional mitochondria can accelerate telomere damage, inducing cellular senescence in vitro and in vivo. Additionally, we have shown that mitochondria are key regulators of the proinflammatory phenotype characteristic of senescent cells — a major contributor to age-related diseases. Our research team is currently deciphering the mechanisms by which mitochondria drive senescence, with the hope of finding new therapies to increase health span during aging. Current and past research has focused on investigating the role of senescent cells during aging of the lung, heart, liver and skin. Complete List of Published Work in MyBibliography: https://www.ncbi.nlm.nih.gov/myncbi/1laSzgMbstc98H/bibliography/public/
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Identificação

Identificação pessoal

Nome completo
Joao Passos

Nomes de citação

  • Passos, Joao

Identificadores de autor

Ciência ID
0119-318B-7B1C
ORCID iD
0000-0001-8765-1890

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Outras Ciências Médicas - Outras Áreas das Ciências Médicas
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2007/03
Concluído
 Biology of Aging (Doutoramento)
Newcastle University, Reino Unido
2002/11
Concluído
 Biochemistry (Mestrado integrado)
Universidade do Porto Faculdade de Ciências, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2007 - 2010 Investigador (Investigação) Newcastle University, Reino Unido
Newcastle University, United Kingdom Centre for Integrated Systems Biology of Aging and Nutrition, Reino Unido
2009 - 2009 Investigador visitante (Investigação) Universität Ulm, Alemanha
University of Ulm Max Planck Institute for Stem Cell Aging, Alemanha

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/01/01 - Atual Professor Catedrático (Docente Universitário) Mayo Clinic Department of Physiology and Biomedical Engineering, Estados Unidos
2018 - Atual Professor Associado (Docente Universitário) Mayo Clinic Department of Physiology and Biomedical Engineering, Estados Unidos
Mayo Clinic Department of Physiology and Biomedical Engineering, Estados Unidos
2017 - 2018 Professor Associado (Docente Universitário) Newcastle University, Reino Unido
2015 - 2017 Professor Auxiliar (Docente Universitário) Newcastle University, Reino Unido
Newcastle University Faculty of Medical Sciences, Reino Unido

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/01/01 - Atual Associate Director of the Robert and Arlene Kogod Aging Center Mayo Clinic Department of Physiology and Biomedical Engineering, Estados Unidos

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - 2018 Deputy leader of “Mechanisms of Aging” theme Newcastle University Institute for Ageing and Health, Reino Unido
Newcastle University Institute for Ageing and Health, Reino Unido
2010 - 2015 Group leader - David Phillips BBSRC Fellow Newcastle University, Reino Unido
2003 - 2007 PhD studentship by the GABBA program Universidade do Porto, Portugal
Projetos

Bolsa

Designação Financiadores
2024/09 - 2029/11 Targeting Cellular Senescence to Extend Healthspan
AG 62413
Co-Investigador Responsável (Co-IR)
Em curso
2023/01/01 - 2028/12/01 Investigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and aging
AG082708
National Institutes of Health, Estados Unidos
Em curso
2021/09 - 2025/08 Development of machine learning software to quantitatively map telomere induced senescence in tissue sections during aging
UG3CA268103
 National Cancer Institute
Em curso
2020/08 - 2025/05 The role of sub-lethal mitochondrial apoptotic stress in cellular senescence
R01AG068048
 National Institute on Aging
2021 - 2023 Postdoctoral Training Program for Research on Aging
T32 AG049672
Investigador responsável
National Institutes of Health, Estados Unidos
Em curso
2013/09 - 2017/09 The impact of melanocyte senescence on skin ageing
BB/L502066/1
 Biotechnology and Biological Sciences Research Council
2014/01 - 2017/04 Regulation of DNA damage signaling by autophagy in senescence
BB/K017314/1
 Biotechnology and Biological Sciences Research Council
2010/11 - 2015/10 High-throughput identification of genes which regulate ROS and DNA damage response in senescence and their effect on hematopoietic stem cells
BB/H022384/1
 Biotechnology and Biological Sciences Research Council

Outro

Designação Financiadores
2018/11/19 - 2023/11/19 Mayo Clinic Startup funds
-
Investigador responsável
Mayo Clinic Research Minnesota, Estados Unidos
Em curso
2019/03/01 - 2021/02/28 Senescence as a potential therapeutic target for ischaemic reperfusion injury following acute myocardial infarction (Co-Princripal Investigator))
PG/19/15/34269 British heart foundation (UK)
Investigador
Em curso
2018/11/19 - 2020/11/19 Investigating p62 as a molecular link between autophagy, senescence and aging
Ted Nash Foundation award
Investigador responsável
Mayo Clinic Research Rochester, Estados Unidos
Em curso
2017/10/01 - 2020/09/30 Investigating the Impact of Cellular Senescence on muscle ageing
BH172641 National Institute for Health Research (NIHR) (UK)
Investigador responsável
Em curso
2016/02/12 - 2020/09/30 The role of cardiomyocyte senescence and cardiac regeneration in ageing (Co-Principal Innvestigator)
PG/15/85/31744 British heart foundation (UK)
Investigador
Em curso
2019/09/01 - 2020/08/31 Investigate the role of BAX/BAK as a driver of inflammation in the aging lung
TR 02377 CCaTS Innovation in Aging Pilot Project
Investigador responsável
Mayo Clinic Research Rochester, Estados Unidos
Em curso
2016/10/01 - 2018/09/30 Investigating senescence during skin ageing
MA-2016-00658N Unilever
Investigador responsável
Concluído
Produções

Publicações

Artigo em revista
  1. Franco, Ana Catarina; Martini, Helene; Victorelli, Stella; Lagnado, Anthony B.; Wyles, Saranya P.; Rowsey, Jennifer L.; Pirius, Nicholas; et al. "Senescent cell transplantation into the skin induces age-related peripheral dysfunction and cognitive decline". Aging Cell 24 1 (2024): https://doi.org/10.1111/acel.14340.
    Publicado • 10.1111/acel.14340
  2. Daniel D. Penrice; Nidhi Jalan-Sakrikar; Diana Jurk; João F. Passos; Douglas A. Simonetto. "Telomere dysfunction in chronic liver disease: The link from aging". Hepatology (2024): https://doi.org/10.1097/HEP.0000000000000426.
    10.1097/HEP.0000000000000426
  3. Ogrodnik, Mikolaj; Carlos Acosta, Juan; Adams, Peter D.; d’Adda di Fagagna, Fabrizio; Baker, Darren J.; Bishop, Cleo L.; Chandra, Tamir; et al. "Guidelines for minimal information on cellular senescence experimentation in vivo". Cell 187 16 (2024): 4150-4175. https://doi.org/10.1016/j.cell.2024.05.059.
    10.1016/j.cell.2024.05.059
  4. Stella Victorelli; João F. Passos. "COPIng with senescence". Nature Cell Biology (2023): https://doi.org/10.1038/s41556-023-01276-9.
    10.1038/s41556-023-01276-9
  5. Goswami, J.; MacArthur, T.A.; Ramachandran, D.; Mahony, C.R.; Howick, A.S.; Price-Troska, T.; Thompson, R.J.; et al. "TELOMERE LENGTH OF PERIPHERAL BLOOD MONONUCLEAR CELLS IS ASSOCIATED WITH DISCHARGE DISPOSITION IN OLDER TRAUMA PATIENTS". Shock 59 3 (2023): 327-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-85149990900&partnerID=MN8TOARS.
    10.1097/SHK.0000000000002059
  6. Farr, J.N.; Saul, D.; Doolittle, M.L.; Kaur, J.; Rowsey, J.L.; Vos, S.J.; Froemming, M.N.; et al. "Local senolysis in aged mice only partially replicates the benefits of systemic senolysis". Journal of Clinical Investigation 133 8 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85152618606&partnerID=MN8TOARS.
    10.1172/JCI162519
  7. Wyles, S.P.; Dashti, P.; Pirtskhalava, T.; Tekin, B.; Inman, C.; Gomez, L.S.; Lagnado, A.B.; et al. "A chronic wound model to investigate skin cellular senescence". Aging 15 8 (2023): 2852-2862. http://www.scopus.com/inward/record.url?eid=2-s2.0-85158075860&partnerID=MN8TOARS.
    10.18632/aging.204667
  8. Ansaf, R.B.; Ziebart, R.; Gudapati, H.; Simoes Torigoe, R.M.; Victorelli, S.; Passos, J.; Wyles, S.P.. "3D bioprinting - a model for skin aging". Regenerative Biomaterials 10 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85168117794&partnerID=MN8TOARS.
    10.1093/rb/rbad060
  9. Witham, M.D.; Granic, A.; Miwa, S.; Passos, J.F.; Richardson, G.D.; Sayer, A.A.. "New Horizons in cellular senescence for clinicians". Age and Ageing 52 7 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85165517525&partnerID=MN8TOARS.
    10.1093/ageing/afad127
  10. Habiballa, L.; Hruby, A.; Granic, A.; Dodds, R.M.; Hillman, S.J.; Jurk, D.; Passos, J.F.; Sayer, A.A.. "Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study". GeroScience (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85164484986&partnerID=MN8TOARS.
    10.1007/s11357-023-00869-4
  11. Gurkar, A.U.; Gerencser, A.A.; Mora, A.L.; Nelson, A.C.; Zhang, A.R.; Lagnado, A.B.; Enninful, A.; et al. "Spatial mapping of cellular senescence: emerging challenges and opportunities". Nature Aging 3 7 (2023): 776-790. http://www.scopus.com/inward/record.url?eid=2-s2.0-85163749922&partnerID=MN8TOARS.
    10.1038/s43587-023-00446-6
  12. Chandra, Abhishek; Lagnado, Anthony B.; Farr, Joshua N.; Schleusner, Megan; Monroe, David G.; Saul, Dominik; Passos, João F.; Khosla, Sundeep; Pignolo, Robert J.. "Bone marrow adiposity in models of radiation- and aging-related bone loss is dependent on cellular senescence". Journal of Bone and Mineral Research (2022): http://dx.doi.org/10.1002/jbmr.4537.
    10.1002/jbmr.4537
  13. Rossiello, Francesca; Jurk, Diana; Passos, João F.; d’Adda di Fagagna, Fabrizio. "Telomere dysfunction in ageing and age-related diseases". Nature Cell Biology 24 2 (2022): 135-147. http://dx.doi.org/10.1038/s41556-022-00842-x.
    Publicado • 10.1038/s41556-022-00842-x
  14. "Cellular senescence: all roads lead to mitochondria.". The FEBS journal (2022): https://doi.org/10.1111/febs.16361.
    10.1111/febs.16361
  15. "Senolytic drugs: Beyond the promise and the hype.". Mechanisms of ageing and development (2022): https://doi.org/10.1016/j.mad.2022.111631.
    10.1016/j.mad.2022.111631
  16. Zhang, X.; Habiballa, L.; Aversa, Z.; Ng, Y.E.; Sakamoto, A.E.; Englund, D.A.; Pearsall, V.M.; et al. "Characterization of cellular senescence in aging skeletal muscle". Nature Aging 2 7 (2022): 601-615. http://www.scopus.com/inward/record.url?eid=2-s2.0-85134306583&partnerID=MN8TOARS.
    10.1038/s43587-022-00250-8
  17. Lee, P.J.; Benz, C.C.; Blood, P.; Börner, K.; Campisi, J.; Chen, F.; Daldrup-Link, H.; et al. "NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health". Nature Aging 2 12 (2022): 1090-1100. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144650665&partnerID=MN8TOARS.
    10.1038/s43587-022-00326-5
  18. Aghali, A.; Khalfaoui, L.; Lagnado, A.B.; Drake, L.Y.; Teske, J.J.; Pabelick, C.M.; Passos, J.F.; Prakash, Y.S.. "Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma". American journal of physiology. Lung cellular and molecular physiology 323 5 (2022): L558-L568. http://www.scopus.com/inward/record.url?eid=2-s2.0-85141888477&partnerID=MN8TOARS.
    10.1152/ajplung.00146.2022
  19. Millar, F.R.; Pennycuick, A.; Muir, M.; Quintanilla, A.; Hari, P.; Freyer, E.; Gautier, P.; et al. "Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer". Cell Reports 41 6 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85141490939&partnerID=MN8TOARS.
    10.1016/j.celrep.2022.111596
  20. Saul, D.; Kosinsky, R.L.; Atkinson, E.J.; Doolittle, M.L.; Zhang, X.; LeBrasseur, N.K.; Pignolo, R.J.; et al. "A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues". Nature Communications 13 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85136077643&partnerID=MN8TOARS.
    10.1038/s41467-022-32552-1
  21. Chandra, A.; Lagnado, A.B.; Farr, J.N.; Doolittle, M.; Tchkonia, T.; Kirkland, J.L.; LeBrasseur, N.K.; et al. "Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity". Aging Cell 21 5 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85127451885&partnerID=MN8TOARS.
    10.1111/acel.13602
  22. "Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.". Cell death and differentiation (2021): https://doi.org/10.1038/s41418-021-00917-6.
    10.1038/s41418-021-00917-6
  23. "Cytoplasmic DNA: sources, sensing, and role in aging and disease.". Cell (2021): https://doi.org/10.1016/j.cell.2021.09.034.
    10.1016/j.cell.2021.09.034
  24. "Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.". The EMBO journal (2021): https://europepmc.org/articles/PMC8090854.
    10.15252/embj.2020106048
  25. "Duodenal mucosal mitochondrial gene expression is associated with delayed gastric emptying in diabetic gastroenteropathy.". JCI insight (2021): https://doi.org/10.1172/jci.insight.143596.
    10.1172/jci.insight.143596
  26. "Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.". Aging cell (2021): https://doi.org/10.1111/acel.13296.
    10.1111/acel.13296
  27. "Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis.". Journal of immunology (Baltimore, Md. : 1950) (2021): https://europepmc.org/articles/PMC7851741.
    10.4049/jimmunol.2001022
  28. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.". Autophagy (2021): https://doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  29. "Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.". eLife (2020): https://europepmc.org/articles/PMC7744091.
    10.7554/elife.65744
  30. Kowald A; Passos JF; Kirkwood TBL. "On the evolution of cellular senescence.". Aging cell (2020): http://europepmc.org/abstract/med/33166065.
    10.1111/acel.13270
  31. Fielder E; Tweedy C; Wilson C; Oakley F; LeBeau FEN; Passos JF; Mann DA; von Zglinicki T; Jurk D. "Anti-inflammatory treatment rescues memory deficits during aging in nfkb1-/- mice.". Aging cell (2020): http://europepmc.org/abstract/med/32915495.
    10.1111/acel.13188
  32. Dookun E; Passos JF; Arthur HM; Richardson GD. "Therapeutic Potential of Senolytics in Cardiovascular Disease.". Cardiovascular drugs and therapy (2020): http://europepmc.org/abstract/med/32979174.
    10.1007/s10557-020-07075-w
  33. Robbins PD; Jurk D; Khosla S; Kirkland JL; LeBrasseur NK; Miller JD; Passos JF; et al. "Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.". Annual review of pharmacology and toxicology (2020): http://europepmc.org/abstract/med/32997601.
    10.1146/annurev-pharmtox-050120-105018
  34. Dookun E; Walaszczyk A; Redgrave R; Palmowski P; Tual-Chalot S; Suwana A; Chapman J; et al. "Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery.". Aging cell (2020): http://europepmc.org/abstract/med/32996233.
    10.1111/acel.13249
  35. Iske J; Seyda M; Heinbokel T; Maenosono R; Minami K; Nian Y; Quante M; et al. "Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.". Nature communications (2020): http://europepmc.org/abstract/med/32855397.
    10.1038/s41467-020-18039-x
  36. Eckhardt BA; Rowsey JL; Thicke BS; Fraser DG; O'Grady KL; Bondar OP; Hines JM; et al. "Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes.". JCI insight (2020): http://europepmc.org/abstract/med/32267250.
    10.1172/jci.insight.135236
  37. Pignolo RJ; Passos JF; Khosla S; Tchkonia T; Kirkland JL. "Reducing Senescent Cell Burden in Aging and Disease.". Trends in molecular medicine (2020): http://europepmc.org/abstract/med/32589933.
    10.1016/j.molmed.2020.03.005
  38. Chandra A; Lagnado AB; Farr JN; Monroe DG; Park S; Hachfeld C; Tchkonia T; et al. "Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss.". Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2020): http://europepmc.org/abstract/med/32023351.
    10.1002/jbmr.3978
  39. Victorelli S; Passos JF. "Telomeres: beacons of autocrine and paracrine DNA damage during skin aging.". Cell cycle (Georgetown, Tex.) (2020): http://europepmc.org/abstract/med/32065062.
    10.1080/15384101.2020.1728016
  40. Hickson LJ; Langhi Prata LGP; Bobart SA; Evans TK; Giorgadze N; Hashmi SK; Herrmann SM; et al. "Corrigendum to 'Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease' EBioMedicine 47 (2019) 446-456.". EBioMedicine (2020): http://europepmc.org/abstract/med/31982828.
    10.1016/j.ebiom.2019.12.004
  41. Cassidy LD; Young ARJ; Young CNJ; Soilleux EJ; Fielder E; Weigand BM; Lagnado A; et al. "Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.". Nature communications (2020): http://europepmc.org/abstract/med/31949142.
    10.1038/s41467-019-14187-x
  42. Vizioli MG; Liu T; Miller KN; Robertson NA; Gilroy K; Lagnado AB; Perez-Garcia A; et al. "Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence.". Genes & development (2020): http://europepmc.org/abstract/med/32001510.
    10.1101/gad.331272.119
  43. Victorelli, Stella; Lagnado, Anthony; Halim, Jessica; Moore, Will; Talbot, Duncan; Barrett, Karen; Chapman, James; et al. "Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction". The EMBO Journal 38 23 (2019): http://dx.doi.org/10.15252/embj.2019101982.
    10.15252/embj.2019101982
  44. Gorgoulis V; Adams PD; Alimonti A; Bennett DC; Bischof O; Bishop C; Campisi J; et al. "Cellular Senescence: Defining a Path Forward.". Cell (2019): http://europepmc.org/abstract/med/31675495.
    10.1016/j.cell.2019.10.005
  45. Hickson LJ; Langhi Prata LGP; Bobart SA; Evans TK; Giorgadze N; Hashmi SK; Herrmann SM; et al. "Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.". EBioMedicine (2019): http://europepmc.org/abstract/med/31542391.
    10.1016/j.ebiom.2019.08.069
  46. Ogrodnik M; Salmonowicz H; Jurk D; Passos JF. "Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence.". Trends in biochemical sciences (2019): http://europepmc.org/abstract/med/31345557.
    10.1016/j.tibs.2019.06.011
  47. Pereira BI; Devine OP; Vukmanovic-Stejic M; Chambers ES; Subramanian P; Patel N; Virasami A; et al. "Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.". Nature communications (2019): http://europepmc.org/abstract/med/31160572.
    10.1038/s41467-019-10335-5
  48. Hari P; Millar FR; Tarrats N; Birch J; Quintanilla A; Rink CJ; Fernández-Duran I; et al. "The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.". Science advances (2019): http://europepmc.org/abstract/med/31183403.
    10.1126/sciadv.aaw0254
  49. Chapman J; Fielder E; Passos JF. "Mitochondrial dysfunction and cell senescence: deciphering a complex relationship.". FEBS letters (2019): http://europepmc.org/abstract/med/31211858.
    10.1002/1873-3468.13498
  50. Ogrodnik, Mikolaj; Zhu, Yi; Langhi, Larissa G.P.; Tchkonia, Tamar; Krüger, Patrick; Fielder, Edward; Victorelli, Stella; et al. "Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis". Cell Metabolism 29 5 (2019): 1233. http://dx.doi.org/10.1016/j.cmet.2019.01.013.
    10.1016/j.cmet.2019.01.013
  51. Walaszczyk, Anna; Dookun, Emily; Redgrave, Rachael; Tual-Chalot, Simon; Victorelli, Stella; Spyridopoulos, Ioakim; Owens, Andrew; et al. "Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction". Aging Cell 18 3 (2019): e12945. http://dx.doi.org/10.1111/acel.12945.
    10.1111/acel.12945
  52. Anderson, Rhys; Lagnado, Anthony; Maggiorani, Damien; Walaszczyk, Anna; Dookun, Emily; Chapman, James; Birch, Jodie; et al. "Length-independent telomere damage drives post-mitotic cardiomyocyte senescence". The EMBO Journal 38 5 (2019): http://dx.doi.org/10.15252/embj.2018100492.
    10.15252/embj.2018100492
  53. Victorelli S; Passos JF. "Reactive Oxygen Species Detection in Senescent Cells.". Methods in molecular biology (Clifton, N.J.) (2019): http://europepmc.org/abstract/med/30474836.
    10.1007/978-1-4939-8931-7_3
  54. Ogrodnik M; Zhu Y; Langhi LGP; Tchkonia T; Krüger P; Fielder E; Victorelli S; et al. "Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.". Cell metabolism (2018): http://europepmc.org/abstract/med/30612898.
    10.1016/j.cmet.2018.12.008
  55. Correia-Melo, Clara; Birch, Jodie; Fielder, Edward; Rahmatika, Dina; Taylor, Jennifer; Chapman, James; Lagnado, Anthony; et al. "Rapamycin improves healthspan but not inflammaging in nf¿b1 -/- mice". Aging Cell 18 1 (2018): e12882. http://dx.doi.org/10.1111/acel.12882.
    10.1111/acel.12882
  56. Habiballa L; Salmonowicz H; Passos JF. "Mitochondria and cellular senescence: Implications for musculoskeletal ageing.". Free radical biology & medicine (2018): http://europepmc.org/abstract/med/30336251.
    10.1016/j.freeradbiomed.2018.10.417
  57. Riley, Joel S; Quarato, Giovanni; Cloix, Catherine; Lopez, Jonathan; O'Prey, Jim; Pearson, Matthew; Chapman, James; et al. "Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis". The EMBO Journal 37 17 (2018): http://dx.doi.org/10.15252/embj.201899238.
    Publicado • 10.15252/embj.201899238
  58. Manzella N; Santin Y; Maggiorani D; Martini H; Douin-Echinard V; Passos JF; Lezoualc'h F; et al. "Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy.". Aging Cell (2018): http://europepmc.org/abstract/med/30003648.
    10.1111/acel.12811
  59. Tarragó, Mariana G.; Chini, Claudia C.S.; Kanamori, Karina S.; Warner, Gina M.; Caride, Ariel; de Oliveira, Guilherme C.; Rud, Micaela; et al. "A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline". Cell Metabolism 27 5 (2018): 1081-1095.e10. http://dx.doi.org/10.1016/j.cmet.2018.03.016.
    Publicado • 10.1016/j.cmet.2018.03.016
  60. Carroll B; Otten EG; Manni D; Stefanatos R; Menzies FM; Smith GR; Jurk D; et al. "Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.". Nature communications (2018): http://europepmc.org/abstract/med/29343728.
    10.1038/s41467-017-02746-z
  61. Birch J; Barnes PJ; Passos JF. "Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease.". Pharmacology & therapeutics (2017): http://europepmc.org/abstract/med/28987319.
    10.1016/j.pharmthera.2017.10.005
  62. Anderson R; Richardson GD; Passos JF. "Mechanisms driving the ageing heart.". Experimental gerontology (2017): http://europepmc.org/abstract/med/29054534.
    10.1016/j.exger.2017.10.015
  63. de Magalhães JP; Passos JF. "Stress, cell senescence and organismal ageing.". Mechanisms of ageing and development (2017): http://europepmc.org/abstract/med/28688962.
    10.1016/j.mad.2017.07.001
  64. Ogrodnik, Mikolaj; Miwa, Satomi; Tchkonia, Tamar; Tiniakos, Dina; Wilson, Caroline L.; Lahat, Albert; Day, Christoper P.; et al. "Cellular senescence drives age-dependent hepatic steatosis". Nature Communications 8 1 (2017): http://dx.doi.org/10.1038/ncomms15691.
    10.1038/ncomms15691
  65. Victorelli S; Passos JF. "Telomeres and Cell Senescence - Size Matters Not.". EBioMedicine (2017): http://europepmc.org/abstract/med/28347656.
    10.1016/j.ebiom.2017.03.027
  66. Schafer, M.; Iijima, K.; White, T.; Haak, A.; Atkinson, EJ.; Birch, J.; Salmonowicz, H.; et al. "Cellular Senescence Drives Pulmonary Fibrosis Pathology". Nature Communications (2017): https://doi.org/10.1038/ncomms14532.
    Publicado
  67. Schafer MJ; White TA; Iijima K; Haak AJ; Ligresti G; Atkinson EJ; Oberg AL; et al. "Cellular senescence mediates fibrotic pulmonary disease.". Nature communications (2017): http://europepmc.org/abstract/med/28230051.
    10.1038/ncomms14532
  68. Birch J; Passos JF. "Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?". BioEssays : news and reviews in molecular, cellular and developmental biology (2017): http://europepmc.org/abstract/med/28217839.
    10.1002/bies.201600235
  69. Salmonowicz H; Passos JF. "Detecting senescence: a new method for an old pigment.". Aging cell (2017): http://europepmc.org/abstract/med/28185406.
    10.1111/acel.12580
  70. Correia-Melo, C; Ichim, G; Passos, Joao; Tait, SW. "Deciphering mitochondrial function through widespread autophagy". Nature Protocols 12 1 (2017): 432-443.
    Publicado
  71. Correia-Melo C; Ichim G; Tait SW; Passos JF. "Depletion of mitochondria in mammalian cells through enforced mitophagy.". Nature protocols (2016): http://europepmc.org/abstract/med/28005069.
    10.1038/nprot.2016.159
  72. Hewitt, Graeme; Carroll, Bernadette; Sarallah, Rezazadeh; Correia-Melo, Clara; Ogrodnik, Mikolaj; Nelson, Glyn; Otten, Elsje G.; et al. "SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair". Autophagy 12 10 (2016): 1917-1930. http://dx.doi.org/10.1080/15548627.2016.1210368.
    10.1080/15548627.2016.1210368
  73. Correia-Melo C; Birch J; Passos JF. "Powering senescence: The ugly side of mitochondria.". Cell cycle (Georgetown, Tex.) (2016): http://europepmc.org/abstract/med/27399972.
    10.1080/15384101.2016.1204852
  74. Neganova I; Shmeleva E; Munkley J; Chichagova V; Anyfantis G; Anderson R; Passos J; et al. "JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells.". (2016): http://europepmc.org/abstract/med/26867034.
    10.1002/stem.2327
  75. Correia-Melo C; Marques FD; Anderson R; Hewitt G; Hewitt R; Cole J; Carroll BM; et al. "Mitochondria are required for pro-ageing features of the senescent phenotype.". (2016): http://europepmc.org/abstract/med/26848154.
    10.15252/embj.201592862
  76. Birch J; Victorelli S; Rahmatika D; Anderson RK; Jiwa K; Moisey E; Ward C; et al. "Telomere Dysfunction and Senescence-associated Pathways in Bronchiectasis.". (2016): http://europepmc.org/abstract/med/27082536.
    10.1164/rccm.201510-2035LE
  77. Correia-Melo C; Passos JF. "Demystifying the role of mitochondria in senescence.". Molecular & cellular oncology (2016): http://europepmc.org/abstract/med/27652315.
    10.1080/23723556.2016.1162896
  78. Correia-Melo, C; DM Marques, F; Anderson R; Hewitt G; Hewitt, R; Carrol, BM; Merz, A SMiwa; et al. "Mitochondria are required for pro-ageing features of the senescent phenotype". The EMBO Journal (2016):
    Publicado
  79. Carroll B; Maetzel D; Maddocks OD; Otten G; Ratcliff M; Smith GR; Dunlop EA; et al. "Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.". (2016): http://europepmc.org/abstract/med/26742086.
    10.7554/eLife.11058
  80. Carroll, B.; Maetzel, D.; Maddocks, O.D.K.; Otten, G.; Ratcliff, M.; Smith, G.R.; Dunlop, E.A.; et al. "Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity". eLife 5 JANUARY201 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84958580792&partnerID=MN8TOARS.
    10.7554/eLife.11058.001
  81. Birch, Jodie; Anderson, Rhys K.; Correia-Melo, Clara; Jurk, Diana; Hewitt, Graeme; Marques, Francisco Madeira; Green, Nicola J.; et al. "DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease". American Journal of Physiology-Lung Cellular and Molecular Physiology 309 10 (2015): L1124-L1137. http://dx.doi.org/10.1152/ajplung.00293.2015.
    10.1152/ajplung.00293.2015
  82. Correia-Melo C; Passos JF. "Mitochondria: Are they causal players in cellular senescence?". (2015): http://europepmc.org/abstract/med/26028303.
    10.1016/j.bbabio.2015.05.017
  83. Wilson CL; Jurk D; Fullard N; Banks P; Page A; Luli S; Elsharkawy AM; et al. "Corrigendum: NF¿B1 is a suppressor of neutrophil-driven hepatocellular carcinoma.". Nature communications (2015): http://europepmc.org/abstract/med/26387912.
    10.1038/ncomms9411
  84. Wilson CL; Jurk D; Fullard N; Banks P; Page A; Luli S; Elsharkawy AM; et al. "NF¿B1 is a suppressor of neutrophil-driven hepatocellular carcinoma.". (2015): http://europepmc.org/abstract/med/25879839.
    10.1038/ncomms7818
  85. Correia-Melo C; Hewitt G; Passos JF. "Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?". (2014): http://europepmc.org/abstract/med/24472138.
    10.1186/2046-2395-3-1
  86. Jurk D; Wilson C; Passos JF; Oakley F; Correia-Melo C; Greaves L; Saretzki G; et al. "Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.". (2014): http://europepmc.org/abstract/med/24960204.
    10.1038/ncomms5172
  87. Neganova I; Tilgner K; Buskin A; Paraskevopoulou I; Atkinson SP; Peberdy D; Passos JF; Lako M. "CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells.". (2014): http://europepmc.org/abstract/med/25375373.
    10.1038/cddis.2014.464
  88. Ivanov A; Pawlikowski J; Manoharan I; van Tuyn J; Nelson DM; Rai TS; Shah PP; et al. "Lysosome-mediated processing of chromatin in senescence.". (2013): http://europepmc.org/abstract/med/23816621.
    10.1083/jcb.201212110
  89. Correia-Melo C; Jurk D; Passos JF. "Robust multiparametric assessment of cellular senescence.". (2013): http://europepmc.org/abstract/med/23296674.
    10.1007/978-1-62703-239-1_27
  90. Hewitt G; von Zglinicki T; Passos JF. "Cell sorting of young and senescent cells.". (2013): http://europepmc.org/abstract/med/23929096.
    10.1007/978-1-62703-556-9_4
  91. Passos JF; Miwa S; von Zglinicki T. "Measuring reactive oxygen species in senescent cells.". (2013): http://europepmc.org/abstract/med/23296664.
    10.1007/978-1-62703-239-1_17
  92. Passos JF; Zglinicki Tv. "Mitochondrial dysfunction and cell senescence--skin deep into mammalian aging.". (2012): http://europepmc.org/abstract/med/22337807.
  93. Hewitt, Graeme; Jurk, Diana; Marques, Francisco D.M.; Correia-Melo, Clara; Hardy, Timothy; Gackowska, Agata; Anderson, Rhys; et al. "Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence". Nature Communications 3 1 (2012): http://dx.doi.org/10.1038/ncomms1708.
    10.1038/ncomms1708
  94. Lawless C; Jurk D; Gillespie CS; Shanley D; Saretzki G; von Zglinicki T; Passos JF. "A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations.". (2012): http://europepmc.org/abstract/med/22359661.
    10.1371/journal.pone.0032117
  95. Passos, J.F.; von Zglinicki, T.. "Mitochondrial dysfunction and cell senescence - Skin deep into mammalian aging". Aging 4 2 (2012): 74-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863442278&partnerID=MN8TOARS.
    10.18632/aging.100432
  96. Neganova I; Vilella F; Atkinson SP; Lloret M; Passos JF; von Zglinicki T; O'Connor JE; et al. "An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.". (2011): http://europepmc.org/abstract/med/21319273.
    10.1002/stem.620
  97. Lawless C; Wang C; Jurk D; Merz A; Zglinicki Tv; Passos JF. "Quantitative assessment of markers for cell senescence.". (2010): http://europepmc.org/abstract/med/20117203.
    10.1016/j.exger.2010.01.018
  98. Passos, João F; Nelson, Glyn; Wang, Chunfang; Richter, Torsten; Simillion, Cedric; Proctor, Carole J; Miwa, Satomi; et al. "Feedback between p21 and reactive oxygen production is necessary for cell senescence". Molecular Systems Biology 6 1 (2010): 347. http://dx.doi.org/10.1038/msb.2010.5.
    Publicado • 10.1038/msb.2010.5
  99. Passos JF; Simillion C; Hallinan J; Wipat A; von Zglinicki T. "Cellular senescence: unravelling complexity.". (2009): http://europepmc.org/abstract/med/19618294.
    10.1007/s11357-009-9108-1
  100. Birket MJ; Passos JF; von Zglinicki T; Birch-Machin MA. "The relationship between the aging- and photo-dependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts.". (2009): http://europepmc.org/abstract/med/19052564.
    10.1038/jid.2008.373
  101. Tsolou A; Passos JF; Nelson G; Arai Y; Zglinicki Tv. "ssDNA fragments induce cell senescence by telomere uncapping.". (2008): http://europepmc.org/abstract/med/18778766.
    10.1016/j.exger.2008.08.043
  102. Passos JF. "Portugal gets ready to embrace ageing research.". (2008): http://europepmc.org/abstract/med/18266070.
    10.1007/s10522-008-9128-8
  103. Pacheco CC; Passos JF; Castro AR; Moradas-Ferreira P; De Marco P. "Role of respiration and glutathione in cadmium-induced oxidative stress in Escherichia coli K-12.". (2008): http://europepmc.org/abstract/med/17968530.
    10.1007/s00203-007-0316-8
  104. Ahmed S; Passos JF; Birket MJ; Beckmann T; Brings S; Peters H; Birch-Machin MA; von Zglinicki T; Saretzki G. "Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.". Journal of cell science (2008): http://europepmc.org/abstract/med/18334557.
    10.1242/jcs.019372
  105. Saretzki G; Walter T; Atkinson S; Passos JF; Bareth B; Keith WN; Stewart R; et al. "Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.". (2008): http://europepmc.org/abstract/med/18055443.
    10.1634/stemcells.2007-0628
  106. Ksiazek K; Passos JF; Olijslagers S; von Zglinicki T. "Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose.". (2008): http://europepmc.org/abstract/med/18082137.
    10.1016/j.bbrc.2007.12.021
  107. Ksiazek K; Passos JF; Olijslagers S; Saretzki G; Martin-Ruiz C; von Zglinicki T. "Premature senescence of mesothelial cells is associated with non-telomeric DNA damage.". (2007): http://europepmc.org/abstract/med/17720141.
    10.1016/j.bbrc.2007.08.047
  108. Passos JF; von Zglinicki T; Kirkwood TB. "Mitochondria and ageing: winning and losing in the numbers game.". (2007): http://europepmc.org/abstract/med/17688237.
    10.1002/bies.20634
  109. Soleimanpour-Lichaei HR; Kühl I; Gaisne M; Passos JF; Wydro M; Rorbach J; Temperley R; et al. "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG.". (2007): http://europepmc.org/abstract/med/17803939.
    10.1016/j.molcel.2007.06.031
  110. Passos, João F; Saretzki, Gabriele; Ahmed, Shaheda; Nelson, Glyn; Richter, Torsten; Peters, Heiko; Wappler, Ilka; et al. "Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence". PLoS Biology 5 5 (2007): e110. http://dx.doi.org/10.1371/journal.pbio.0050110.
    Publicado • 10.1371/journal.pbio.0050110
  111. Passos JF; Saretzki G; von Zglinicki T. "DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?". (2007): http://europepmc.org/abstract/med/17986462.
    10.1093/nar/gkm893
  112. Passos JF; von Zglinicki T. "Methods for cell sorting of young and senescent cells.". (2007): http://europepmc.org/abstract/med/17634572.
    10.1007/978-1-59745-361-5_4
  113. Passos JF; Von Zglinicki T. "Oxygen free radicals in cell senescence: are they signal transducers?". (2006): http://europepmc.org/abstract/med/17090417.
    10.1080/10715760600917151
  114. Getliffe KM; Martin Ruiz C; Passos JF; von Zglinicki T; Nwokolo CU. "Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients.". (2006): http://europepmc.org/abstract/med/16394794.
    10.1097/00042737-200602000-00005
  115. Passos JF; von Zglinicki T; Saretzki G. "Mitochondrial dysfunction and cell senescence: cause or consequence?". (2006): http://europepmc.org/abstract/med/16608398.
    10.1089/rej.2006.9.64
  116. Passos JF; von Zglinicki T. "Mitochondria, telomeres and cell senescence.". (2005): http://europepmc.org/abstract/med/15963673.
    10.1016/j.exger.2005.04.006
  117. Pacheco CC; Passos JF; Moradas-Ferreira P; De Marco P. "Strain PM2, a novel methylotrophic fluorescent Pseudomonas sp.". (2003): http://europepmc.org/abstract/med/14592720.
    10.1016/S0378-1097(03)00692-X
Capítulo de livro
  1. Victorelli, S.; Passos, J.F.. "Telomeres and cell homeostasis in aging". 297-309. 2022.
  2. Passos, J.F.; Nelson, G.; Von Zglinicki, T.. "Telomeres, senescence, oxidative stress, and heterogeneity". 43-56. 2008.
Livro
  1. Passos, J.F.; Von Zglinicki, T.. Methods for cell sorting of young and senescent cells. 2007.
    10.1385/1-59745-361-7:33
Pré-impressão
  1. Joao Passos; Helene Martini; Jodie Birch; Francisco Marques; Stella Victorelli; Anthony Lagnado; Nicholas Pirius; et al. "Mitochondrial metabolism and epigenetic crosstalk drive the SASP". 2024. https://doi.org/10.21203/rs.3.rs-5278203/v1.
    10.21203/rs.3.rs-5278203/v1
  2. Dominik Saul; Diana Jurk; Madison L. Doolittle; Robyn Laura Kosinsky; David G Monroe; Nathan K. LeBrasseur; Paul D. Robbins; et al. "Distinct secretomes in p16- and p21- positive senescent cells across tissues". 2023. https://doi.org/10.1101/2023.12.05.569858.
    10.1101/2023.12.05.569858
  3. Joao Passos; James Chapman; Hanna Salmonowicz; Stella Victorelli; Helene Martini; Joel Riley; Catherine Cloix; et al. "Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP". 2022. https://doi.org/10.21203/rs.3.rs-1247316/v1.
    10.21203/rs.3.rs-1247316/v1
  4. Abhishek Chandra; Anthony B. Lagnado; Joshua N. Farr; Megan Schleusner; David G. Monroe; Christine Hachfeld; João F. Passos; Sundeep Khosla; Robert J. Pignolo. "Roles of cellular senescence in driving bone marrow adiposity in radiation- and aging-associated bone loss". 2021. https://doi.org/10.1101/2021.09.07.459232.
    10.1101/2021.09.07.459232
  5. Fernández-Duran I; Tarrats N; Birch J; Hari P; Millar FR; Muir M; Quintanilla A; et al. "Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence". 2020. http://europepmc.org/abstract/PPR/PPR227108.
    10.1101/2020.10.16.342949

Outros

Outra produção
  1. Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction.. 2023. Redgrave, R.; Dookun, E.; Booth, L.; Folaranm, O.; Tual-Chalot, S.; Gill, J.; Owens, A.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85167632457&partnerID=MN8TOARS.
    10.21203/rs.3.rs-2776501/v1
  2. Inactivation of histone chaperone HIRA unmasks a link between normal embryonic development of melanoblasts and maintenance of adult melanocyte stem cells. 2022. Jaber-Hijazi, F.; Swaminathan, K.; Gilroy, K.; Wenzel, A.T.; Lagnado, A.; Kirschner, K.; Robertson, N.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85131212029&partnerID=MN8TOARS.
    10.1101/2022.04.22.489166
  3. Clearance of senescent cells following cardiac ischemia-reperfusion injury improves recovery. 2020. Dookun E; Walaszczyk A; Redgrave R; Palmowski P; Tual-Chalot S; Suwana A; Chapman J; et al. http://europepmc.org/abstract/PPR/PPR156490.
    10.1101/2020.04.28.065789
  4. Temporal inhibition of autophagy reveals segmental reversal of aging with increased cancer risk: Supplemental Move 1. 2019. Cassidy L; Young AR; Young CN; Soilleux EJ; Fielder E; Weigand BM; Brais R; et al. http://europepmc.org/abstract/PPR/PPR68230.
    10.1101/528984
  5. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.. 2018. Hari P; Millar FR; Tarrats N; Birch J; Rink CJ; Fernandez-Duran I; Muir M; et al. http://europepmc.org/abstract/PPR/PPR61498.
    10.1101/466755
  6. Length-independent telomere damage drives cardiomyocyte senescence. 2018. Anderson R; Lagnado A; Maggiorani D; Walaszczyk A; Dookun E; Chapman J; Birch J; et al. http://europepmc.org/abstract/PPR/PPR47459.
    10.1101/394809
  7. Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death. 2018. Riley J; Quarato G; Lopez J; O'Prey J; Pearson M; Chapman J; Sesaki H; et al. http://europepmc.org/abstract/PPR/PPR18265.
    10.1101/272104
Atividades

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018 - Atual Mechanisms of Aging and Development (0047-6374) Elsevier
2016 - Atual Biogerontology (1573-6768) Springer-Verlag
2014 - Atual Aging Cell (1474-9728) Wiley (Blackwell Publishing)
Distinções

Prémio

2022 Robert & Arlene Kogod Center on Aging Director’s award
Mayo Clinic Minnesota, Estados Unidos
2019 FEBS Anniversary Prize of the Gesellschaft für Biochemie und Molekularbiologie
2010 Best talk prize at the Swedish Telomere Telomerase Meeting
2007 British Society for Research into Aging prize
2003 Prof. Dr. Fernando Serrão Prize
Universidade do Porto, Portugal

Outra distinção

2009 Poster prize at IAH/ICM Research day
2006 Best poster prize 3rd International Conference on Functional Genomics of Aging, Sicily
2005 Best poster prize at British Society for Research into Aging scientific meeting London UK