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I am Junior Researcher at NOVA Medical School (NMS), Universidade NOVA de Lisboa (UNL) in Portugal. My academic journey began with a degree in Molecular and Cellular Biology in 2010, followed by a Master in Biotechnology in 2012, both from NOVA School of Science and Technology, UNL. In 2019, I finished my PhD in Mechanisms of Disease and Regenerative Medicine (UNL/UAlgarve) with the project that aimed to study the modulation of carotid body (CB) activity as a therapeutic intervention in metabolic diseases. During my PhD, I had the opportunity to participate in a research project in collaboration with GSK and Galvani Bioelectronics dedicated to the pioneer studies of CB neuromodulation to treat type 2 diabetes (T2D). In fact, this work was distinguished with the Pulido Valente Ciência 2018 Award (Pulido Valente Foundation|FCT), for the best publication in the biomedical sciences in Portugal and my PhD work was also recognized by the International Society for Arterial Chemoreception with the Fernando de Castro ISAC Trainee Award (2017). After finished my PhD I spent 9 months as a Postdoc under the supervision of Philippe Blancou at the l'Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, France. Trying to pursue a career in science, immediately after defending my PhD, I successfully applied to a Junior Research contract from Stimulus of Scientific Employment Individual by FCT (CEECIND/02428/2018). In the journey to my scientific independence in 2021, I was granted (principal investigator) by FCT with an exploratory project (EXPL/MED-NEU/0733/2021) dedicated to the develop of a closed-loop approach for the real time neuromodulation of the carotid sinus nerve to treat T2D. In 2023, I received the L'Oréal Portugal Medals of Honor for Women in Science with a project that aimed to study the neuromodulation of the carotid sinus nerve activity to T2D. This award recognized the therapeutic potential of the carotid sinus nerve neuromodulation to T2D. Since I start my scientific journey, 13 years ago, I published 36 peer-reviewed publications. In addition to my scientific career, between 2018 and 2020 I had teaching duties as Invited Assistant of Pharmacology and since 2021 I am an Assistant Professor in the degree of Nutritional Sciences and Master courses at NMS|UNL.
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Identificação

Identificação pessoal

Nome completo
Joana Filipa Canais da Costa Sacramento

Nomes de citação

  • Joana F. Sacramento

Identificadores de autor

Ciência ID
051A-D3AD-AEAD
ORCID iD
0000-0002-0853-4918

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2019/02/18
Concluído
 Mechanisms of Disease and Regenerative Medicine (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
"Modulation of carotid body activity as a therapeuthic intervention in metabolic diseases" (TESE/DISSERTAÇÃO)
 Unanimously approved with Very Good
2016 - 2016
Concluído
 FELASA Category B (Outros)
Sociedade Portuguesa de Ciências em Animais de Laboratório (SPCAL), Portugal
2012/10/15
Concluído
 Mestrado em Biotecnologia (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Cafeína e resistência à insulina: qual o papel da adenosina?" (TESE/DISSERTAÇÃO)
 18 (0 - 20)
2010/09/09
Concluído
 Licenciatura em Biologia Molecular e Celular (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
""n/a"" (TESE/DISSERTAÇÃO)
 13 (0 - 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2020 - Atual Investigador (Investigação) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/03/04 - 2019/12/20 Pós-doutorado (Investigação) Institut de Pharmacologie Moléculaire et Cellulaire, França
2015/10/15 - 2015/12/18 Investigador visitante (Investigação) Universidad de Valladolid Departamento de Bioquímica y Biología Molecular y Fisiología, Espanha
2012/12/22 - 2013/02/28 Estagiário de Investigação (Investigação) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012/11/12 - 2012/12/21 Investigador visitante (Investigação) Universidad de Valladolid Departamento de Bioquímica y Biología Molecular y Fisiología, Espanha
2011/09/05 - 2012/10/15 Estagiário de Investigação (Investigação) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2008/10/01 - 2009/05/29 Estagiário de Investigação (Investigação) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/09/01 - 2020/08/31 Assistente Convidado (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/01/01 - 2019/02/18 PhD Student (PD/BD/105890/2014): Pro-RegeM - Programa de Doutoramento em Mecanismos de Doença e Medicina Regenerativa Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/04/07 - 2018/04/08 Project Management Course Universidade Nova de Lisboa, Portugal
2017/10/16 - 2017/10/20 1st FLxFlow Course: Principles and applications of flow cytometry.  Instituto de Medicina Molecular, Portugal
2016/11/07 - 2016/11/11 23rd EASD Scientists Training Course: Metabolic phenotyping of mice.  Deutsches Diabetes-Zentrum Leibniz-Zentrum für Diabetes-Forschung, Alemanha
2016/10/23 - 2016/10/27 Workshop on Optimising Surgical Techniques and Perioperative Care in Laboratory Rodents  Newcastle University, Reino Unido
2016/06/27 - 2016/06/30 Champalimaud - SPCAL Course on Laboratory Animal Science for RAT/MOUSE and ZEBRAFISH Centro Champalimaud, Portugal
2016/01/26 - 2016/01/27 Workshop - Show me your mouse and I will show you your phenotype – histopathology in biomedical Universidade de Lisboa Faculdade de Medicina, Portugal
2015/03/19 - 2015/03/20 Intellectual Property Course Universidade Nova de Lisboa, Portugal
2014/03/01 - 2014/12/31 Research fellow. EXPL/NEU-SCC/2183/2013 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014/12/01 - 2014/12/02 Workshop “Hypoxia, molecular mechanisms and clinical translation” Instituto de Biomedicina de Sevilla, Espanha
2014/09/14 - 2014/09/15 2nd DZD Diabetes Research School Deutsches Diabetes-Zentrum Leibniz-Zentrum für Diabetes-Forschung, Alemanha
2013/03/01 - 2013/12/31 Research Fellow, PTDC/SAU-ORG/111417/2009 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013/11/05 - 2013/11/09 1st DZD Diabetes Research School Deutsches Diabetes-Zentrum Leibniz-Zentrum für Diabetes-Forschung, Alemanha
2013/07/27 - 2013/08/02 Summer School in Neuroendocrinology Federation of European Neuroscience Societies, Bélgica
Projetos

Projeto

Designação Financiadores
2023 - Atual Closed-loop electroceutical targeting of carotid sinus nerve to treat type 2 diabetes.
n/a
Investigador responsável
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 L'Oréal Portugal
2023 - Atual PAS GRAS - De-Risking Metabolic, Environmental and Behavioural Determinants of Obesity in Children, Adolescents and Young Adults
101080329
Investigador
Horizon Europe
2021/01/01 - 2025/12/31 Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

BioResources 4 Sustainability, Portugal

Universidade NOVA de Lisboa, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2023/12/31 Moving towards closed-loop bioelectronic medicine for type 2 diabetes: real-time neuromodulation of carotid sinus nerve.
EXPL/MED-NEU/0733/2021
Investigador responsável
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2022/01/01 - 2023/12/31 Exploring pro-inflammatory interleukins as major players in the link carotid body-metabolic deregulation in obesity and obstructive sleep apnea
2021.09398.CBM
Investigador
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2019/01/01 - 2019/12/31 iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB)
UID/Multi/04462/2019
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016/08 - 2019/06 Pre-clinical Rodent plan for type 2 diabetes.
D00006317
Investigador
Galvani Bioelectronics Ltd
Concluído
2013/11 - 2016/04 The Carotid Body as a therapeutic target in metabolic diseases: Mapping carotid sinus nerve activity in diabetes rat models.
D00006317
Investigador
GlaxoSmithKline
Concluído
2014/03/15 - 2014/12/31 Mapping the sympathetic efferent activity in carotid-body mediated insulin resistance.
EXPL/NEU-SCC/2183/2013
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia
Concluído
2013/03/01 - 2013/12/31 Is insulin a stimulus for carotid body activation? A new mechanism for insulin resistance and hypertension.
PTDC/SAU-ORG/111417/2009
Bolseiro de Investigação
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Outro

Designação Financiadores
2020/07/13 - Atual Decoding neural activity of the carotid sinus nerve: can we selectively modulate the metabolic fibers to treat type 2 diabetes?
CEECIND/02428/2018
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
Em curso
Produções

Publicações

Artigo em revista
  1. Conde, Silvia V.; Martins, Fatima O.; Sacramento, Joana F.. "Carotid body interoception in health and disease". Autonomic Neuroscience 255 (2024): 103207. http://dx.doi.org/10.1016/j.autneu.2024.103207.
    10.1016/j.autneu.2024.103207
  2. Silvia V. Conde; Joana F. Sacramento; Ciro Zinno; Alberto Mazzoni; Silvestro Micera; Maria P. Guarino. "Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives". Frontiers in Neuroscience (2024): http://dx.doi.org/10.3389/fnins.2024.1378473.
    10.3389/fnins.2024.1378473
  3. Maria P. Guarino; Joana F. Sacramento; Fonseca-Pinto, Rui; Conde, SV. "Targeting the sympathetic nervous system to improve vascular function in diabetes". Revista Portuguesa de Diabetologia 19 1 (2024): 40-47. http://www.revportdiabetes.com/wp-content/uploads/2024/05/RPD_MAR_2024_Artigo_Revisao_40-47.pdf.
    Publicado
  4. Gonçalo M. Melo; Adriana M. Capucho; Joana F. Sacramento; José Ponce-de-Leão; Marcos V. Fernandes; Inês F. Almeida; Fátima O. Martins; Silvia V. Conde. "Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety". Nutrients (2023): https://doi.org/10.3390/nu16010067.
    10.3390/nu16010067
  5. Joana L. Fernandes; Fátima O. Martins; Elena Olea; Jesus Prieto-Lloret; Patricia Braga; Joana F. Sacramento; Catarina O. Sequeira; et al. "Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation". Antioxidants (2023): https://www.mdpi.com/2076-3921/12/11/1910.
    10.3390/antiox12111910
  6. Gabriela Tavares; Daniela Rosendo-Silva; Flávia Simões; Hans Eickhoff; Daniela Marques; Joana F. Sacramento; Adriana M. Capucho; et al. "Circulating Dopamine Is Regulated by Dietary Glucose and Controls Glucagon-like 1 Peptide Action in White Adipose Tissue". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032464.
    10.3390/ijms24032464
  7. Cabral MD; Fátima O. Martins; Martins, IB; Melo, Bernardete F.; Joana F. Sacramento; Conde, SV; Prieto-Lloret, Jesus. "Effect of Carotid Body Denervation on Systemic Endothelial Function in a Diabetic Animal Model". Advances in Experimental Medicine and Biology 1427 (2023): 115-125.
    Publicado
  8. Sacramento, Joana F.; Caires, Iolanda; Guarino, Maria P.; Ribeiro, Maria J.; Santiago, João C. P.; Timóteo, Ana T.; Selas, Mafalda; Mota-Carmo, Miguel; Conde, Silvia V.. "Increased Abdominal Perimeter Differently Affects Respiratory Function in Men and Women". Advances in Experimental Medicine and Biology (2023): 135-141. http://dx.doi.org/10.1007/978-3-031-32371-3_15.
    10.1007/978-3-031-32371-3_15
  9. Sacramento, Joana F.; Melo, Bernardete F.; Prieto-Lloret, Jesus; Conde, Silvia V.. "Chronic Metformin Administration Does Not Alter Carotid Sinus Nerve Activity in Control Rats". Advances in Experimental Medicine and Biology (2023): 203-208. http://dx.doi.org/10.1007/978-3-031-32371-3_22.
    10.1007/978-3-031-32371-3_22
  10. Capucho, Adriana M.; Chegão, Ana; Martins, Fátima O.; Melo, Bernardete F.; Madeira, Natália; Sacramento, Joana F.; Fonseca, Rosalina; Vicente Miranda, Hugo; Conde, Sílvia V.. "Carotid Body Resection Prevents Short-Term Spatial Memory Decline in Prediabetic Rats Without Changing Insulin Signaling in the Hippocampus and Prefrontal Cortex". Advances in Experimental Medicine and Biology (2023): 143-152. http://dx.doi.org/10.1007/978-3-031-32371-3_16.
    10.1007/978-3-031-32371-3_16
  11. Lopes-Coelho, Filipa; Nunes, Sofia; Martins, Filipa; Hipólito, Ana; Gouveia-Fernandes, Sofia; Domingues, Germana; Melo, Bernardete; et al. "Propranolol therapy for cerebral cavernous malformations". World Academy of Sciences Journal 4 3 (2022): http://dx.doi.org/10.3892/wasj.2022.158.
    10.3892/wasj.2022.158
  12. Melo, Bernardete F.; Joana F. Sacramento; Adriana M. Capucho; Dinis Sampaio-Pires; Cláudia S. Prego; Conde, Silvia V.. "Long-term hypercaloric diet consumption exacerbates age-induced dysmetabolism and carotid body dysfunction: beneficial effects of CSN denervation". Frontiers in Physiology (2022):
    Aceite para publicação
  13. Conde, Silvia V.; Sacramento, Joana F.; Melo, Bernardete F.; Fonseca-Pinto, Rui; Romero-Ortega, Mario I.; Guarino, Maria P.. "Blood Pressure Regulation by the Carotid Sinus Nerve: Clinical Implications for Carotid Body Neuromodulation". Frontiers in Neuroscience 15 (2022): http://dx.doi.org/10.3389/fnins.2021.725751.
    Publicado • 10.3389/fnins.2021.725751
  14. Tavares, G.; Marques, D.; Barra, C.; Rosendo-Silva, D.; Costa, A.; Rodrigues, T.; Gasparini, P.; et al. "Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes". Molecular Metabolism 51 (2021): 101241. http://dx.doi.org/10.1016/j.molmet.2021.101241.
    10.1016/j.molmet.2021.101241
  15. Martins, Fátima O.; Sacramento, Joana F.; Olea, Elena; Melo, Bernardete F.; Prieto-Lloret, Jesus; Obeso, Ana; Rocher, Asuncion; et al. "Chronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independently of Adipose Tissue Deregulation". Antioxidants 10 8 (2021): 1233. http://dx.doi.org/10.3390/antiox10081233.
    Publicado • 10.3390/antiox10081233
  16. Melo, Bernardete F.; Prieto-Lloret, Jesus; Cabral, Marlene D.; Martins, Fatima O.; Martins, Inês B.; Sacramento, Joana F.; Ruivo, Pedro; Carvalho, Tânia; Conde, Silvia V.. "Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-85606-7.
    Publicado • 10.1038/s41598-021-85606-7
  17. Silvia V. Conde; Joana F. Sacramento; Martins, Fátima Patrícia da Costa Oliveira. "Immunity and the carotid body: implications for metabolic diseases". Bioelectronic Medicine 6 1 (2020): http://dx.doi.org/10.1186/s42234-020-00061-5.
    10.1186/s42234-020-00061-5
  18. Joana F. Sacramento; Kryspin Andrzejewski; Bernardete F. Melo; Maria J. Ribeiro; Ana Obeso; Silvia V Conde. "Exploring the Mediators that Promote Carotid Body Dysfunction in Type 2 Diabetes and Obesity Related Syndromes". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/15/5545.
    10.3390/ijms21155545
  19. Sacramento, Joana F.; Martins, Fátima O.; Rodrigues, Tiago; Matafome, Paulo; Ribeiro, Maria J.; Olea, Elena; Conde, Silvia V.. "A2 Adenosine Receptors Mediate Whole-Body Insulin Sensitivity in a Prediabetes Animal Model: Primary Effects on Skeletal Muscle". Frontiers in Endocrinology 11 (2020): http://dx.doi.org/10.3389/fendo.2020.00262.
    10.3389/fendo.2020.00262
  20. Cunha-Guimaraes, Joao P; Guarino, Maria P; Timoteo, Ana T; Caires, Iolanda; Sacramento, Joana F; Ribeiro, Maria J; Selas, Mafalda; et al. "Carotid body chemosensitivity: early biomarker of dysmetabolism in humans". European Journal of Endocrinology (2020): http://dx.doi.org/10.1530/eje-19-0976.
    10.1530/eje-19-0976
  21. Cracchiolo, Marina; Sacramento, Joana F.; Mazzoni, Alberto; Panarese, Alessandro; Carpaneto, Jacopo; Conde, Silvia V.; Micera, Silvestro. "Decoding Neural Metabolic Markers From the Carotid Sinus Nerve in a Type 2 Diabetes Model". IEEE Transactions on Neural Systems and Rehabilitation Engineering 27 10 (2019): 2034-2043. http://dx.doi.org/10.1109/tnsre.2019.2942398.
    Publicado • 10.1109/tnsre.2019.2942398
  22. Sacramento, Joana F.; Olea, Elena; Ribeiro, Maria J.; Prieto-Lloret, Jesus; Melo, Bernardete F.; Gonzalez, Constancio; Martins, Fatima O.; Monteiro, Emilia C.; Conde, Silvia V.. "Contribution of adenosine and ATP to the carotid body chemosensory activity in ageing". The Journal of Physiology 597 19 (2019): 4991-5008. http://dx.doi.org/10.1113/jp274179.
    Publicado • 10.1113/jp274179
  23. Melo, Bernardete F.; Sacramento, Joana F.; Ribeiro, Maria J.; Prego, Claudia S.; Correia, Miguel C.; Coelho, Joana C.; Cunha-Guimaraes, Joao P.; et al. "Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats". Nutrients 11 6 (2019): 1197. http://dx.doi.org/10.3390/nu11061197.
    10.3390/nu11061197
  24. Sacramento JF; Chew DJ; Melo BF; Donegá M; Dopson W; Guarino MP; Robinson A; et al. "Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes.". Diabetologia (2018): http://europepmc.org/abstract/med/29332196.
    10.1007/s00125-017-4533-7
  25. Conde, S.V.; Sacramento, J.F.; Guarino, M.P.. "Carotid body: A metabolic sensor implicated in insulin resistance". Physiological Genomics 50 3 (2018): 208-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052514682&partnerID=MN8TOARS.
    10.1152/physiolgenomics.00121.2017
  26. Sacramento, Joana F.; Melo, Bernardete F.; Conde, Sílvia V.. "Adenosine Mediates Hypercapnic Response in the Rat Carotid Body via A2A and A2B Receptors". Advances in Experimental Medicine and Biology 1071 (2018): 89-93. http://dx.doi.org/10.1007/978-3-319-91137-3_11.
    Publicado • 10.1007/978-3-319-91137-3_11
  27. Ribeiro MJ; Sacramento JF; Gallego-Martin T; Olea E; Melo BF; Guarino MP; Yubero S; et al. "High fat diet blunts the effects of leptin on ventilation and on carotid body activity.". The Journal of physiology 596 15 (2017): 3187-3199. http://europepmc.org/abstract/med/29271068.
    10.1113/jp275362
  28. Conde SV; Ribeiro MJ; Melo BF; Guarino MP; Sacramento JF; Conde, S.V.; Ribeiro, M.J.; et al. "Insulin resistance: a new consequence of altered carotid body chemoreflex?". The Journal of physiology 595 1 (2017): 31-41. http://europepmc.org/abstract/med/27027507.
    10.1113/jp271684
  29. Sacramento JF; Ribeiro MJ; Rodrigues T; Olea E; Melo BF; Guarino MP; Fonseca-Pinto R; et al. "Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver.". Diabetologia (2017): http://europepmc.org/abstract/med/27744526.
    10.1007/s00125-016-4133-y
  30. Franco, M.C.; Fonseca, A.R.; Sacramento, J.; Melo, B.; Conde, S.V.; Guarino, M.P.. "Micro Computed Tomography Detects Changes in Liver Density in Control and in Prediabetes Rats". Procedia Manufacturing 12 (2017): 106-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029842099&partnerID=MN8TOARS.
    10.1016/j.promfg.2017.08.014
  31. Conde SV; Monteiro EC; Sacramento JF. "Purines and Carotid Body: New Roles in Pathological Conditions.". Frontiers in pharmacology (2017): http://europepmc.org/abstract/med/29311923.
    10.3389/fphar.2017.00913
  32. Sacramento JF; Ribeiro MJ; Rodrigues T; Guarino MP; Diogo LN; Seiça R; Monteiro EC; Matafome P; Conde SV. "Insulin resistance is associated with tissue-specific regulation of HIF-1a and HIF-2a during mild chronic intermittent hypoxia.". Respiratory physiology & neurobiology (2016): http://europepmc.org/abstract/med/26993367.
    10.1016/j.resp.2016.03.007
  33. Sacramento JF; Ribeiro MJ; Yubero S; Melo BF; Obeso A; Guarino MP; Gonzalez C; Conde SV. "Disclosing caffeine action on insulin sensitivity: effects on rat skeletal muscle.". European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2015): http://europepmc.org/abstract/med/25661425.
    10.1016/j.ejps.2015.01.011
  34. Sacramento JF; Gonzalez C; Gonzalez-Martin MC; Conde SV. "Adenosine Receptor Blockade by Caffeine Inhibits Carotid Sinus Nerve Chemosensory Activity in Chronic Intermittent Hypoxic Animals.". Advances in experimental medicine and biology (2015): http://europepmc.org/abstract/med/26303475.
    10.1007/978-3-319-18440-1_15
  35. Conde, Sílvia V.; Sacramento, Joana F.; Guarino, Maria P.; Gonzalez, Constancio; Obeso, Ana; Diogo, Lucilia N.; Monteiro, Emilia C.; Ribeiro, Maria J.. "Carotid body, insulin, and metabolic diseases: unraveling the links". Frontiers in Physiology 5 (2014): http://dx.doi.org/10.3389/fphys.2014.00418.
    10.3389/fphys.2014.00418
  36. Guarino MP; Ribeiro MJ; Sacramento JF; Conde SV. "Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity.". (2013): http://europepmc.org/abstract/med/22976123.
    10.1007/s11357-012-9475-x
  37. Ribeiro MJ; Sacramento JF; Gonzalez C; Guarino MP; Monteiro EC; Conde SV. "Carotid body denervation prevents the development of insulin resistance and hypertension induced by hypercaloric diets.". (2013): http://europepmc.org/abstract/med/23530003.
    10.2337/db12-1463
Capítulo de livro
  1. Conde, SV; Joana F. Sacramento; Martins, Fátima Patrícia da Costa Oliveira. "Sleep and the impact of high caffeine consumption: Implications for coffee consumption". In Coffee in Health and Disease Prevention, 529-540. 2024.
  2. Conde, Silvia V.; Lages, Marlene; Guarino, Maria P.; Sacramento, Joana F.. "Carotid Bodies:Use of Chemosensitivity as a Biomarker in Prediabetes". In Biomarkers in Disease: Methods, Discoveries and Applications, 1-25. Springer International Publishing, 2022.
    10.1007/978-3-030-81303-1_38-1
  3. Dos Santos, Eliano; Sacramento, Joana F.; Melo, Bernardete F.; Conde, Sílvia V.. "Carotid Body Dysfunction in Diet-Induced Insulin Resistance Is Associated with Alterations in Its Morphology". In Advances in Experimental Medicine and Biology, 103-108. Springer International Publishing, 2018.
    Publicado • 10.1007/978-3-319-91137-3_13
  4. Guarino, Maria Pedro; Sacramento, Joana; Ribeiro, Maria João; Conde, Sílvia Vilares. "Caffeine, Insulin Resistance, and Hypertension". In Coffee in Health and Disease Prevention, 747-755. Elsevier, 2015.
    10.1016/b978-0-12-409517-5.00083-8
Poster em conferência
  1. Tavares, Gabriela; Marques, Daniela; Reis-Costa, Ana; Barra, Cátia; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Peripheral dopamine directly acts on insulin sensitive tissue to regulate insulin signalling and metabolic function". Trabalho apresentado em 55th Annual Scientific Meeting of European Society for Clinical Investigation (ESCI), virtual meeting, 2021, 2021.
  2. Fátima O. Martins; Bernardete F. Melo; Jesus Prieto-Lloret; Joana F. Sacramento; Silvia V. Conde. Autor correspondente: Fátima O. Martins. "Unravel hidden mechanisms of chronic metformin effects on diet-induced dysmetabolism". Trabalho apresentado em 17th Portuguese Diabetes Meeting from Portuguese Society of Diabetology, 2021.
  3. Mateus Capucho, Adriana; Melo, Bernardete F.; Fátima O. Martins; Joana F. Sacramento; Silvia V. Conde. "Adriana M. Capucho, Bernardete F. Melo, Fátima O. Martins, Joana F. Sacramento, Silvia V. Conde Carotid Body modulation impacts the expression of hypothalamic proteins that regulate satiety .". Trabalho apresentado em 24th Congress for the study of Obesity, 2020.
  4. Fátima O. Martins; Inês B. Martins; Melo, Bernardete F.; Maria J. Ribeiro; Sacramento, Joana F.; Silvia V. Conde. "O papel do sistema adenosinérgico nos diferentes tecidos sensíveis à insulina". Trabalho apresentado em 16º Encontro SPD, 2020.
  5. Joana F. Sacramento; Melo, Bernardete F.; Olea, Elena; Obeso, Ana; Rocher A; Rodrigues, T.; Prieto-Lloret, Jesus; et al. "A hiperinsulinémia contribui para o desenvolvimento da resistência à insulina na apneia obstrutiva do sono independentemente da obesidade.". Trabalho apresentado em 16th Portuguese Congress of Diabetes, 2020.
  6. Melo, Bernardete F.; Jesus Prieto-Lloret; Marlene D. Cabral; Inês B. Martins; Joana F. Sacramento; Silvia V. Conde. "Quais os agentes moleculares responsáveis pelo dano endotelial induzido por dietas hipercalóricas, na artéria pulmonar?". Trabalho apresentado em 16th Portuguese Congress on Diabetes, Vilamoura, Portugal, 2020.
  7. Lopes-Coelho, Filipa; Martins F.; Hipólito A.; Melo, Bernardete F.; Joana F. Sacramento; Silvia V. Conde; Pereira AS.; Serpa, Jacinta. "Reactive Oxigen Species (ROS) a motor in Endothelial Cells (ECs) activation.". Trabalho apresentado em ISCaM2019 (International Society of Cancer Metabolismo), 6th Annual meeting, 2019.
  8. Tavares, Gabriela; Marques, Daniela; Costa, Ana; Barra, Cátia; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Modulation of dopaminergic signaling with bromocriptine improves glucose and lipid metabolism in an obese type 2 diabetic animal model". Trabalho apresentado em 55th Annual Meeting of the European Association for the Study of Diabetes Meeting (EASD), 2019.
  9. Melo, Bernardete F.; Prego CS.; Joana F. Sacramento; Silvia V. Conde. "Carotid body modulation: a therapeutic approach to induce adipose tissue browning and ameliorate metabolism promoting weight loss.". Trabalho apresentado em 55th Annual Meeting of the European Association for the Study of Diabetes, 2019.
  10. Tavares, Gabriela ; Marques, D.; Barra, Cátia; Costa S.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; et al. "Modulation of dopaminergic signalling with Bromocriptine improves glucose and lipid metabolism in an obese type 2 diabetic animal model.". Trabalho apresentado em 55th Annual Meeting of the European Association for the Study of Diabetes, 2019.
  11. Joana F. Sacramento; Batista CC.; Melo, Bernardete F.; Prego CS.; Silvia V. Conde. "Impact of carotid sinus nerve resection on metabolic dysfunction induced by ageing and by long-term hypercaloric diet consumption in rats.". Trabalho apresentado em Physiology 2019, 2019.
  12. Barra, Cátia; Costa, A.; Tavares, Gabriela ; Marques, D.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; et al. "Bromocriptine decreases hepatic steatosis by modulation of the dopamine signaling in liver.". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  13. Tavares, Gabriela ; Marques, D.; Barra, Cátia; Costa, A.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; et al. "Modulation of dopaminergic signaling with Bromocriptine improves glucose and lipid metabolism in white and brown adipose tissue of an obese type 2 diabetic animal model.". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  14. Tavares, Gabriela; Marques, Daniela; Barra, Cátia; Reis-Costa, Ana; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; et al. "Modulation of dopaminergic signalling with Bromocriptine improves glucose and lipid metabolism in white and brown adipose tissue in a type 2 diabetic obese animal model". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI), 2019.
  15. Melo, Bernardete F.; Prego CS.; Joana F. Sacramento; Silvia V. Conde. "Carotid body modulation: a therapeutic target to produce adipose tissue browning and ameliorate metabolism promoting weight loss.". Trabalho apresentado em ECO2019, 26th European Congress on Obesity, 2019.
    10.1109/bsn.2006.14
  16. Joana F. Sacramento; Batista CC.; Melo, Bernardete F.; Prego CS.; Silvia V. Conde. "O consumo de dieta hipercalórica a longo prazo agrava a disfunção metabólica induzida pela idade: efeitos benéficos da ressecção do nervo do seio carotídeo.". Trabalho apresentado em 15th Portuguese Congress of Diabetes, 2019.
  17. Barra, Cátia; Costa, A.; Tavares, Gabriela ; Marques, D.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; et al. "A bromocriptina reduz a esteatose hepática por modulação da sinalização dopaminérgica no fígado.". Trabalho apresentado em 15th Portuguese Congress of Diabetes, 2019.
  18. Martins, Fátima Patrícia da Costa Oliveira; Martins IB.; Melo, Bernardete F.; Ribeiro, MJ.; Joana F. Sacramento; Silvia V. Conde. "Estão alterações da sinalização e metabolismo da adenosina no fígado associadas à progressão da diabetes tipo 2?". Trabalho apresentado em 15th Portuguese Congress of Diabetes, 2019.
  19. Joana F. Sacramento; Melo, Bernardete F.; Prego CS.; Silvia V. Conde. "Long-term hypercaloric diet consumption exacerbates age-induced metabolic dysfunction: beneficial effects of CSN denervation.". Trabalho apresentado em 54th Annual Meeting of the European Association for the Study of Diabetes, 2018.
  20. Martins IB.; Melo, Bernardete F.; Prego CS.; Joana F. Sacramento; Silvia V. Conde. "Adenosine metabolism is deregulated in Brown adipose tissue in diet-induced type 2 diabetes.". Trabalho apresentado em 54th Annual Meeting of the European Association for the Study of Diabetes, 2018.
  21. Melo, Bernardete F.; Prego CS.; Joana F. Sacramento; Silvia V. Conde. "Beneficial effects of carotid sinus nerve resection on white adipose tissue metabolism.". Trabalho apresentado em Europhysiology 2018, 2018.
  22. Ribeiro, MJ; Prego CS.; Joana F. Sacramento; Cunha-Guimarães JP.; Silvia V. Conde. "Acute vs chronic administration of leptin in obese rats: effects on blood pressure, sympathetic activity and glucose homeostasis.". Trabalho apresentado em Europhysiology 2018, 2018.
  23. Prego CS.; Melo, Bernardete F.; Joana F. Sacramento; Silvia V. Conde. "Carotid sinus nerve resection reduces weight gain and improves metabolic function in high-fat animals via an increase in brown adipose tissue function and decrease in its inflammation.". Trabalho apresentado em Europhysiology 2018, 2018.
  24. Silvia V. Conde; Cunha-Guimarães JP.; Timoteo AT.; Caires, Iolanda; Joana F. Sacramento; Ribeiro, MJ.; Selas M; et al. "Carotid body chemosensitivity correlates with insulinemia and insulin resistance but not with blood pressure in metabolic syndrome patients.". Trabalho apresentado em Europhysiology 2018, 2018.
  25. Cracchiolo, Marina; Joana F. Sacramento; Mazzoni, Alberto; Panarese, Alessandro; Carpaneto, Jacopo; Silvia V. Conde; Micera, Silvestro. "Carotid Sinus nerve activity as a neural marker for type 2 diabetes.". Trabalho apresentado em Bioelectronic Medicine: Technology Targeting Molecular Mechanisms – Symposium, 2018.
  26. Ribeiro MJ.; Joana F. Sacramento; Cunha-Guimarães JP.; Silvia V. Conde. "Can we target leptin action in the carotid body to ameliorate obesity induced hypertension?". Trabalho apresentado em I NoTeS Congress - Novel Therapeutic Strategies for Noncommunicable Diseases, 2018.
  27. Melo, Bernardete F.; Joana F. Sacramento; Prego CS.; Ribeiro, MJ.; Martins IB.; Guarino, MP; Silvia V. Conde. "What is the most appropriate rat model to study type 2 diabetes?". Trabalho apresentado em IV Congresso SPCAL, 2018.
  28. Melo, Bernardete F.; Prego CS.; Joana F. Sacramento; Silvia V. Conde. "Bilateral carotid sinus nerve resection decreases weight gain, body fat mass and obesity associated co-morbidities in rodents.". Trabalho apresentado em ECO2018 the 25th European Congress on Obesity, 2018.
  29. Ribeiro MJ.; Joana F. Sacramento; Melo, Bernardete F.; Guarino, MP; Silvia V. Conde. "A resseção do nervo do seio cartotídeo diminiu o ganho de peso, a massa gorda corporal e melhora as comorbilidades associadas à obesidade.". Trabalho apresentado em 14th Portuguese Congress of Diabetes, 2018.
  30. Joana F. Sacramento; Marques, D.; Costa, A.; Barra, Cátia; Santos AS.; Rodrigues, T.; Joana F. Sacramento; et al. "A bromocriptina na diabetes tipo 2: alterações da sensibilidade à insulina no fígado e no tecido adiposo.". Trabalho apresentado em 14th Portuguese Congress of Diabetes, 2018.
  31. Cláudia S. Prego; Melo, Bernardete F.; Joana F. Sacramento; Silvia V. Conde. "A ressecção do nervo do seio carotídeo diminuiu o ganho de peso, a massa gorda corporal e melhora as comorbilidades associadas à obesidade.". Trabalho apresentado em 14th Portuguese Congress of Diabetes. Albufeira, Portugal, 2018.
  32. Maria J. Ribeiro; Joana F. Sacramento; Melo, Bernardete F.; Maria P. Guarino; Silvia V. Conde. "Efeito da leptina na ventilação e pressão arterial em ratos submetidos a uma dieta hipercalórica.". Trabalho apresentado em 14th Portuguese Congress of Diabetes. Albufeira, Portugal, 2018.
  33. Joana F. Sacramento; Ribeiro, MJ.; Rodrigues, T.; Matafome, Paulo; Guarino, Maria Pedro; Seiça, R.; Silvia V. Conde. "A2 adenosine receptors mediate chronic caffeine effects on insulin sensitivity.". Trabalho apresentado em 53rd Annual Meeting of the European Association for the Study of Diabetes, 2017.
  34. Silvia V. Conde; Joana F. Sacramento; Chew D; Melo, Bernardete F.; Donega M; Dopson W; Robinson, A.; et al. "Bilateral electrical neuromodulation of the carotid sinus nerves improves insulin and glucose tolerance in rodent type 2 diabetes models.". Trabalho apresentado em 53rd Annual Meeting of the European Association for the Study of Diabetes, 2017.
  35. Melo, Bernardete F.; Prego CS.; Correia MC; Cabral MD; Joana F. Sacramento; Silvia V. Conde. "Beneficial effects of carotid sinus nerve resection on obesity co-morbidities.". Trabalho apresentado em 53rd Annual Meeting of the European Association for the Study of Diabetes, 2017.
  36. Martins IB.; Ribeiro, MJ.; Melo, Bernardete F.; Rodrigues, T.; Joana F. Sacramento; Seiça, R.; Matafome, Paulo; Silvia V. Conde. "Alterations in adenosine metabolism and adenosine receptor expression are associated with insulin resistance.". Trabalho apresentado em 53rd Annual Meeting of the European Association for the Study of Diabetes, 2017.
  37. Matafome, Paulo; Marques, D.; Santos AS.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; Seiça, R.; Silvia V. Conde. "Bromocriptine changes adipocyte lipid metabolismo improving insulin sensitivity in obese diabetic rats.". Trabalho apresentado em 53rd Annual Meeting of the European Association for the Study of Diabetes., 2017.
  38. Silvia V. Conde; Joana F. Sacramento. "Adenosine mediates hypercapnic response in the rat carotid body via A2A and A2B receptors.". Trabalho apresentado em 38th Congress of International Union of Physiological Societies (IUPS), 2017.
  39. Marques, D.; Santos AS.; Neves I.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; Sereno J.; et al. "A bromocriptina melhora a sensibilidade á insulina, sistémica e do tecido adiposo, por modulação da sinalização dopaminérgica.". Trabalho apresentado em 13rd Portuguese Congress of Diabetes, 2017.
  40. Martins IB.; Ribeiro, MJ.; Melo, Bernardete F.; Rodrigues, T.; Joana F. Sacramento; Seiça, R.; Matafome, Paulo; Silvia V. Conde. "Is adenosine an important mediator in insulin sensitivity?". Trabalho apresentado em iMed Conference® 9.0, 2017.
  41. Dos Santos, E.; Joana F. Sacramento; Melo, Bernardete F.; Silvia V. Conde. "Carotid body dysfunction in diet-induced insulin resistance is associated with alterations in its morphology.". Trabalho apresentado em iMed Conference® 9.0, 2017.
  42. Dos Santos, E.; Joana F. Sacramento; Silvia V. Conde. "Cellular senescence in the carotid body and metabolic dysfunction with age.". Trabalho apresentado em In4Med – Coimbra's Scientific and Medical Congress, 2017.
  43. Melo, Bernardete F.; Cláudia S. Prego; Miguel C. Correia; Marlene D. Cabral; Joana F. Sacramento; Silvia V. Conde. "Beneficial effects of carotid body denervation in obesity co-morbilities.". Trabalho apresentado em Annual Meeting of the European Association for the Study of Diabetes (EASD). Lisbon, Portugal, 2017.
  44. Paulo Matafome; Daniela Marques; A. S. Santos; Tiago Rodrigues; Joana F. Sacramento; Melo, Bernardete F.; Raquel Seiça; Silvia V. Conde. "Bromocriptine changes adipocyte lipid metabolism improving insulin sensitivity in obese diabetic rats". Trabalho apresentado em Annual Meeting of the European Association for the Study of Diabetes (EASD). Lisbon, Portugal, 2017.
  45. Panarese, Alessandro; Cracchiolo, Marina; Carpaneto, Jacopo; Joana F. Sacramento; Silvia V. Conde; Mazzoni, Alberto; Micera, Silvestro. "Temporal structure of metabolic modulation of autonomic nervous system activity.". Trabalho apresentado em Neuroscience 2016, 2016.
  46. Joana F. Sacramento; Melo, Bernardete F.; Rodrigues, T.; Coelho, JC.; Olea, Elena; Ribeiro MJ.; Guarino, MP; et al. "Carotid body transection restores glucose and lipid homeostasis in prediabetes animal models.". Trabalho apresentado em 52nd Annual Meeting of the European Association for the Study of Diabetes, 2016.
  47. Joana F. Sacramento; Prieto-Lloret, Jesus; Melo, Bernardete F.; Silvia V. Conde. "High fat diet increases basal carotid sinus nerve activity and the responsiveness to hypoxia.". Trabalho apresentado em Physiology 2016, 2016.
  48. Guarino, MP; Joana F. Sacramento; Fonseca-Pinto R.; Silvia V. Conde. "Partial inhibition of insulin secretion in prediabetes animal models improves peripheral insulin action and restores sympathetic activity.". Trabalho apresentado em Physiology 2016, 2016.
  49. Prieto-Lloret, Jesus; Melo, Bernardete F.; Martins IB.; Joana F. Sacramento; Silvia V. Conde. "Diabetes differently affects endothelial function in the aorta and pulmonary artery.". Trabalho apresentado em Physiology 2016, 2016.
  50. Melo, Bernardete F.; Prieto-Lloret, Jesus; Joana F. Sacramento; Silvia V. Conde. "Effects of acute and chronic metformin administration on pulmonary artery endothelial function.". Trabalho apresentado em Physiology 2016, 2016.
  51. Joana F. Sacramento; Silvia V. Conde; Melo, Bernardete F.; Patel S.; Chew D; Dopson W; Pickov V; et al. "Electrical Neuromodulation of the Carotid Sinus Nerve as a Novel Therapeutic Approach for the Treatment of Type 2 Diabetes.". Trabalho apresentado em 76th American Diabetes Association Scientific Sessions, 2016.
  52. Inês B. Martins; Jesus Prieto-Lloret; Bernardete F. Melo; Joana F. Sacramento; Silvia V. Conde. "Diabetes progression differently affects endothelial function in the aorta and pulmonary artery.". Trabalho apresentado em iMed Conference 8.0. Lisbon, Portugal, 2016.
    10.1109/cic.2005.1588045
  53. Ribeiro MJ.; Joana F. Sacramento; Rodrigues, T.; Matafome, Paulo; Diogo LN,; Seiça RM; Guarino, MP; Silvia V. Conde. "Unraveling the molecular mechanisms involved in chronic intermittent hypoxia-induced insulin resistance.". Trabalho apresentado em 51st Annual Meeting of the European Association for the Study of Diabetes, 2015.
  54. Ferreira CR.; Martins IB.; Melo, Bernardete F.; Joana F. Sacramento; Guarino, MP; Silvia V. Conde. "Changes in the adenosine/ nitric oxide signaling pathway are associated soleus muscle insulin resistance.". Trabalho apresentado em 51st Annual Meeting of the European Association for the Study of Diabetes, 2015.
  55. Coelho, JC.; Melo, Bernardete F.; Rodrigues, T.; Matafome, Paulo; Joana F. Sacramento; Ribeiro, MJ.; Guarino, MP; Seiça, R.; Silvia V. Conde. "Chronic caffeine intake restores insulin sensitivity in high-sucrose diet rats through adaptations in adipose tissue metabolism.". Trabalho apresentado em 51st Annual Meeting of the European Association for the Study of Diabetes, 2015.
  56. Melo, Bernardete F.; Joana C. Coelho; Tiago Rodrigues; Joana F. Sacramento; Maria J. Ribeiro; Maria P. Guarino; Raquel Seiça; Paulo Matafome; Silvia V. Conde. "Chronic caffeine intake restores insulin sensitivity in high-sucrose diet rats throught adaptations in adipose tissue.". Trabalho apresentado em Annual Meeting of the European Association for the Study of Diabetes (EASD). Stochkolm, Sweeden., 2015.
  57. Joana F. Sacramento; Coelho, JC.; Melo, Bernardete F.; Guarino, MP; Silvia V. Conde. "Assessment of caffeine dose and time of administration required for resetting of insulin sensitivity in high-sucrose rats.". Trabalho apresentado em 50th Annual Meeting of the European Association for the Study of Diabetes, 2014.
  58. Ribeiro, MJ.; Joana F. Sacramento; Yubero, S.; Melo, Bernardete F.; Obeso, Ana; Gonzalez, C.; Guarino, MP; Silvia V. Conde. "Disclosing acute caffeine action on insulin sensitivity: effects on skeletal muscle.". Trabalho apresentado em 50th Annual Meeting of the European Association for the Study of Diabetes, 2014.
  59. Joana F. Sacramento; Matafome, Paulo; Rodrigues, T.; Ribeiro, MJ.; Diogo, LN.; Seiça RM.; Monteiro, EC.; Silvia V. Conde. "Alterations in adipose tissue metabolism and signaling contribute to insulin resistance induced by chronic intermittent hypoxia.". Trabalho apresentado em VI Annual Meeting of IBILI (Institute for Biomedical Imaging and Life Sciences), 2014.
  60. Melo, Bernardete F.; Tiago Rodrigues; Joana F. Sacramento; Paulo Matafome; Maria J. Ribeiro; Raquel Seiça; Maria P. Guarino; Silvia V. Conde. "Carotid sinus nerve resection avoids weight gain and reverses dyslipidemia in metabolic syndrome and prediabetes animal models.". Trabalho apresentado em Fundação Astrazeneca Innovate Competition, iMed Conference 6.0. Lisbon, 2014.
  61. Joana C. Coelho; Melo, Bernardete F.; Joana F. Sacramento; Maria P. Guarino; Silvia V. Conde. "Establishing the caffeine dose that chronically restores insulin sensitivity in animal model of prediabetes". Trabalho apresentado em Fundação Astrazeneca Innovate Competition, iMed conference 6.0. Lisbon, 2014.
  62. Ribeiro, MJ; Joana F. Sacramento; Guarino, MP; Silvia V. Conde. "Can carotid sinus nerve resection be a therapeutic approach for the treatment of insulin resistance?". Trabalho apresentado em 49th Annual Meeting of the European Association for the Study of Diabetes, 2013.
    10.1055/s-0039-1679549
  63. Joana F. Sacramento; Ribeiro, MJ.; Guarino, MP; Silvia V. Conde. "Acute vs chronic caffeine: are the effects on insulin sensitivity mediated by altered insulin/AMPK signaling pathway?". Trabalho apresentado em 37th Congress of International Union of Physiological Societies, 2013.
  64. Ribeiro, MJ.; Joana F. Sacramento; Constancio G.; Guarino, MP; Silvia V. Conde. "Carotid body activity is increased in rat hypercaloric models of insulin resistance and hypertension.". Trabalho apresentado em 37th Congress of International Union of Physiological Societies, 2013.
  65. Rodrigues PM.; Silvia V. Conde; Joana F. Sacramento; Marinho AT.; Ribeiro, MJ.; Antunes AMM.; Marques MM.; Monteiro, EC.; Pereira SA. . "New insights on personalized medicine – drug response variation in type II diabetes. The Nevirapine Story. ". Trabalho apresentado em Fundação AstraZeneca Innovate Competition – iMed, 2013.
  66. Joana F. Sacramento; Ribeiro, MJ.; Gonzalez, C.; Antunes DD.; Guarino, MP; Silvia V. Conde. "Effect of chronic caffeine administration on Glut-4 and AMPK a1 expression and plasma catecholamines in age-induced insulin resistance rats.". Trabalho apresentado em 48th Annual Meeting of the European Association for the Study of Diabetes, 2012.
  67. Joana F. Sacramento; Ribeiro, MJ.; Guarino, MP; Silvia V. Conde. "O efeito do consumo crónico de cafeína na sensibilidade à insulina é mediado pelos receptores de adenosina A2.". Trabalho apresentado em Annual Meeting of the Portuguese Society of Diabetology, 2012.
Pré-impressão
  1. Gonçalo M Melo; Adriana M. Capucho; Joana F. Sacramento; José Ponce-de-Leão; Marcos V. Fernandes; Inês F. Almeida; Fátima O. Martins; Silvia V. Conde. "Overnutrition during Pregnancy and Lactation Induces Gender-Dependent Dysmetabolism in the Offspring Accompanied by Heightened Stress and Anxiety". 2023. https://doi.org/10.20944/preprints202311.1921.v1.
    10.20944/preprints202311.1921.v1
Resumo em conferência
  1. Tavares, Gabriela ; Marques, D.; Barra, Cátia; Costa, A.; Rodrigues, T.; Joana F. Sacramento; Melo, Bernardete F.; et al. "P102-F - Bromocriptine decreases hepatic steatosis by modulation of the dopamine signaling in liver". Trabalho apresentado em Special Issue: Abstracts of the 53rd Annual Scientific Meeting of the European Society for Clinical Investigation “The Clocks of Metabolism and Disease, Coimbra, 2019.
    doi.org/10.1111/eci.13109
  2. Cracchiolo, Marina; Joana F. Sacramento; Mazzoni, Alberto; Panarese, Alessandro; Carpaneto, Jacopo; Conde, Silvia V.; Micera, Silvestro. "High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model". Trabalho apresentado em 9th International IEEE/EMBS Conference on Neural Engineering, San Francisco, 2019.
    Publicado • 10.1109/ner.2019.8717052
  3. Joana F. Sacramento; Melo, Bernardete F.; Silvia V. Conde. "Long-term hypercaloric diet consumption exacerbates age-induced metabolic dysfunction: beneficial effects of CSN denervation.". Trabalho apresentado em 54th EASD Annual Meeting of the European Association for the Study of Diabetes., Berlim, 2018.
    doi.org/10.1007/s00125-018-4693-0
  4. Martins IB.; Melo, Bernardete F.; Prego CS.; Joana F. Sacramento; Silvia V. Conde. "Adenosine metabolism is deregulated in brown adipose tissue in diet-induced type 2 diabetes.". Trabalho apresentado em Adenosine metabolism is deregulated in brown adipose tissue in diet-induced type 2 diabetes., Berlim, 2018.
    doi.org/10.1007/s00125-018-4693-0
  5. Inês B. Martins; Melo, Bernardete F.; Cláudia S. Prego; Joana F. Sacramento; Silvia V. Conde. "O metabolismo da adenosina no tecido adiposo castanho encontra-se desregulado em modelos animais de diabetes tipo 2 induzidos por dietas hipercalóricas.". Trabalho apresentado em 14th Portuguese Congress of Diabetes., Albufeira, 2018.
    Publicado
  6. Joana F. Sacramento; Daniel J. Chew; Melo, Bernardete F.; Matteo Donegá; Wesley Dopson; Maria P. Guarino; Alison Robinson; et al. "Modulação bioelectrónica da actividade do nervo do seio carotídeo: potencial terapêutica para diabetes tipo 2.". Trabalho apresentado em 14th Portuguese Congress of Diabetes, Albufeira, 2018.
    Publicado
  7. Joana F. Sacramento; Ribeiro, MJ.; Rodrigues, T.; Matafome, Paulo; Guarino, MP; Seiça, R.; Silvia V. Conde. "A2 adenosine receptors mediate chronic caffeine effects on insulin sensitivity.". Trabalho apresentado em Abstracts of the 53rd EASD Annual Meeting, Diabetologia, Lisbon, 2017.
    doi.org/10.1007/s00125-017-4350-z
  8. Joana F. Sacramento; Melo, Bernardete F.; Rodrigues, T.; Coelho, JC.; Olea, Elena; Ribeiro, MJ.; Guarino, MP; et al. "Carotid body transection restores glucose and lipid homeostasis in prediabetes animal models.". Trabalho apresentado em Abstracts of the 52nd EASD Annual Meeting in Diabetologia, Munich, 2016.
    doi.org/10.1007/s00125-016-4046-9
  9. Joana F. Sacramento; Fonseca-Pinto R.; Guarino, MP; Silvia V. Conde. "Decreased endogenous insulin production improves whole-body insulin sensitivity: is this a sympathetically mediated effect?". Trabalho apresentado em 9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015) in Autonomic Neuroscience, Stressa, 2015.
  10. Sacramento, Joana. "Assessment of caffeine dose and time of administration required for resetting of insulin sensitivity in high-sucrose rats.". 2014.
    10.1007/s00125-014-3355-0
  11. Sacramento, Joana. "Effect of acute caffeine administration on glucose homeostasis and blood pressure.". 2014.
  12. Sacramento, Joana. "Can carotid sinus nerve resection be a therapeutic approach for the treatment of insulin resistance?". 2013.
    10.1007/s00125-013-3012-z
  13. Joana F. Sacramento; Ribeiro, MJ.; Guarino, MP; Silvia V. Conde. "Are the acute caffeine effects on insulin sensitivity mediated by adenosine receptors?". Trabalho apresentado em 6th European Congress of Pharmacology, Granada, 2013.
  14. Sacramento, Joana. "Effect of chronic caffeine administration on Glut-4 and AMPK a1 expression and plasma catecholamines in age-induced insulin resistance rats.". 2012.
    10.1007/s00125-012-2688-9
Tese / Dissertação
  1. Sacramento, Joana Filipa Canais da Costa. "Modulation of carotid body activity as a therapeutic intervention in metabolic diseases". Doutoramento, 2019. http://hdl.handle.net/10362/64174.
  2. Sacramento, Joana Filipa Canais da Costa. "Cafeína e resistência à insulina: qual o papel da adenosina?". Mestrado, 2012. http://hdl.handle.net/10362/13960.

Outros

Outra produção
  1. The carotid body mediates GLP-1 actions on glucose homeostasis. 2023. DS Sampaio-Pires; FO Martins; M Capucho; C Barosa; Joana F. Sacramento; GM Melo; JG Jones; Silvia V Conde. https://novaresearch.unl.pt/en/publications/1389fdb5-c3a1-4d5e-98fe-e04a4308da97.
  2. Insulin resistence in obstructive sleep apnea: Is there a role for mitochondrial dysfunction in the liver?. 2022. J. L. Fernandes; Fátima O. Martins; B. F. Melo; E. Olea; J. Prietro-Lloret; A. Obeso; A. Rocher; Joana F. Sacramento; Silvia V Conde. https://novaresearch.unl.pt/en/publications/e130a5cb-2ab3-47c9-bdc6-43c39da422cf.
  3. Carotid body: a new intervenient of GLP-1 effects in cardiometabolic homeostasis. 2022. D. Sampaio-Pires; Fátima O. Martins; B. F. Melo; Joana F. Sacramento; Silvia V Conde. https://novaresearch.unl.pt/en/publications/2dcad14c-0197-405d-9209-38e3e3d87a28.
  4. Modulation of adenosine signaling in the adipose tissue as a potential therapeutical approach for obesity. 2022. Silvia V Conde; A. C. F. Soares; D. Rosendo-Silva; B. F. Melo; I. B. Martins; A. M. Capucho; S. F. Farreca; et al. https://novaresearch.unl.pt/en/publications/d0777df6-355a-4017-bd28-b1ac4c2d8667.
  5. Carotid body modulation prevents cognitive dysfunction and neurodegenerative processes in prediabetic rats. 2022. A. M. Capucho; B. F. Melo; A. Chegao; Fátima O. Martins; Joana F. Sacramento; N. Madeira; R. Fonseca; Hugo Vicente Miranda; Silvia V Conde. https://novaresearch.unl.pt/en/publications/0e7763f7-3357-4d8e-af1f-078fa6f73e6c.
  6. Contribution of impaired hepatic mitochondrial bioenergetics to insulin resistance in Obstructive Sleep Apnea. 2022. J. L. Fernandes; Fátima O. Martins; B. F. Melo; E. Olea; J. Prieto-Lloret; A. Obeso; A. Rocher; et al. https://novaresearch.unl.pt/en/publications/e5901052-926e-49e4-9efc-1be4a087774a.
  7. Carotid body modulation overcome adipose tissue catecholamine resistance in obesity. 2022. Fátima O. Martins; B. F. Melo; Joana F. Sacramento; D. Rosendo-Silva; E. Olea; P. Matafome; Silvia V Conde. https://novaresearch.unl.pt/en/publications/fbe03511-6a6a-444f-bf0d-735fe6f16f63.
  8. GLP1 acts on the carotid body to modulate glucose homeostasis and cardiorespiratory responses. 2022. D. S. Pires; Fátima O. Martins; A. M. Capucho; B. F. Melo; Joana F. Sacramento; Silvia V Conde. https://novaresearch.unl.pt/en/publications/7cbbe24a-cca5-4d35-bc1d-53980b5e50d9.
  9. Effect of nutritional status and interventions on spontaneous and hypoxia-evoked carotid sinus nerve activity in rats. 2022. Joana F. Sacramento; J. P. Cunha-Guimaraes; C. S. Prego; Silvia V Conde. https://novaresearch.unl.pt/en/publications/7a0c9166-9352-439a-ac89-d8930d30c050.
  10. Carotid body, intermittent hypoxia and metabolism. 2020. Joana F. Sacramento; B. F. Melo; E. Olea; A. Obeso; A. Rocher; T. Rodrigues; J. Prieto-Lloret; et al. https://novaresearch.unl.pt/en/publications/45ac7d19-78a4-4841-b078-7cad185efceb.
  11. Hyperinsulinemia due to altered insulin secretion contributes to insulin resistance in chronic intermittent hypoxia independently of obesity. 2019. Joana F. Sacramento; Bernardete F. Melo; Elena Olea; Ana Obeso; Asuncion Rocher; Tiago Rodrigues; Jesus Prieto-Lloret; et al. https://novaresearch.unl.pt/en/publications/20f3e633-d025-41e9-b235-823c1923c23b.
    10.1183/13993003.congress-2019.OA4935
  12. Bilateral electrical modulation of carotid sinus nerve improves glucose homeostasis in rodent type 2 diabetes model. 2017. Silvia V Conde; Joana F. Sacramento; D. Chew; B. F. Melo; M. Donega; W. Dopson; A. Robinson; et al. https://novaresearch.unl.pt/en/publications/bcf56c3e-4607-492b-a413-421d1337fcad.
  13. Beneficial leeffects of carotid sinus nerve resection on obesity comorbidities. 2017. B. F. Melo; C. S. Prego; M. C. Correia; MG Cabral; Joana F. Sacramento; Silvia V Conde. https://novaresearch.unl.pt/en/publications/6a38ce9e-0a75-4dff-94f7-0bd0a97790b8.
  14. Carotid sinus nerve transection restores glucose and lipid homeostasis in prediabetes animal models. 2016. Joana F. Sacramento; B. F. Melo; T. Rodrigues; José Luís Passos Coelho; E. Olea; M. J. Ribeiro; Maria Pedro Guarino; et al. https://novaresearch.unl.pt/en/publications/e060b3d9-2e6f-4dd1-b274-06b5a917be38.
  15. Changes in the adenosine / nitric oxide signalling pathways are associated skeletal muscle insulin resistance. 2015. Bernardete Melo; Joana F. Sacramento; Silvia V Conde. https://novaresearch.unl.pt/en/publications/7494a897-b1b9-4e57-837f-5ea22a80145e.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2025/03/08 Joana F. Sacramento, Fatima O. Martins, Cláudia S. Prego, Claúdia C. Batista, Bernardete F Melo, Rafael Carecho, Cristina Barosa, Dinis Sampaio-Pires, John G Jones, Silvia V. Conde - Qual o papel do corpo carotídeo na disfunção hepática na doença metabólica? 21º Congresso Português de Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2025/02/07 Joana F. Sacramento, Fátima O. Martins, Rafael Carecho, Cláudia S. Prego, Bernardete F. Melo, Inês Fernandes, Cláudia Batista, Cristina Barosa, John G. Jones, Silvia V. Conde - Impact of carotid sinus nerve resection on liver glucose and lipid metabolism in hyper caloric diets animals. 55ª Reunião da Sociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2024/11/29 Diabetes e qualidade (de)vida: avanços tecnológicos não dispensam hábitos saudáveis - Keynote speaker II Jornadas Healthy Campus
Politécnico de Leiria (Peniche, Portugal)
2024/11/07 Joana F. Sacramento, Gonçalo M. Melo, Cláudia S. Prego, Sílvia V. Conde - Contribution of adenosine and ATP to the carotid body-mediated hypoxic ventilatory responses: a metabolic switch between control and dysmetabolic states. 3rd International Meeting of the Portuguese Society of Physiology
Sociedade Portuguesa de Fisiologia (Porto, Portugal)
2024/07/25 Joana F. Sacramento and Sílvia V. Conde - Blockade of P2X3 ATP receptors decreases carotid body-mediated hypoxic ventilatory responses in high-fat rats International Society for Autonomic Neuroscience (ISAN) Congress 2024
(Birmingham, Reino Unido)
2024/06/05 Marcos V. Fernandes, Joana F. Sacramento*, Adriana M. Capucho, Gonçalo M. Melo, José Ponce-de-Leão, Fátima O. Martins, Eduardo Colombari, Sílvia V. Conde. Comparing the effects of carotid sinus nerve denervation versus estradiol on metabolic parameters in ovariectomized hypercaloric fed female rats. *presenting author 58th ESCI Annual Scientific Meeting (ASM)
European Society for Clinical Investigation (Barcelona, Espanha)
2024/03 Marcos V. Fernandes, Joana F. Sacramento*, Adriana M. Capucho, Gonçalo M. Melo, José Ponce-de-Leão, Fátima O. Martins, Eduardo Colombari, Sílvia V. Conde. Explorando novas abordagens terapêuticas para o dismetabolismo na menopausa: comparação entre os efeitos da desnervação do nervo do seio carotídeo versus administração de estradiol em ratos fêmeas ovariectomizadas e alimentadas com dieta hiperlipídica. *presenting author 20.º Congresso Português de Diabetes
Sociedade Portuguesa de Diabetologia (Vilamoura, Portugal)
2024/02 Sacramento JF and Conde SV. ADENOSINE AND ATP MEDIATE THE HYPOXIC VENTILATORY RESPONSES IN HIGH-FAT FED RATS 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology
Sociedade Portuguesa de Farmacologia (Lisboa, Portugal)
2023 Conde SV, Sampaio-Pires D, Capucho AM, Sacramento JF*, Melo GM, Martins FO. The carotid body is involved in GLP-1 effects on glucose homeostasis. *Presenting author Physiology 2023
The Physiological Society (Harrogate, Reino Unido)
2022/02 Sacramento JF, Cunha-Guimarães JP, Prego CS, Conde SV. Carotid sinus nerve activity in animals with metabolic dysfunction correlates with insulin resistance but not with fasting glycemia. XXIth Meeting of the International Society of Arterial Chemoreception.
NOVA Medical School, Universidade Nova de Lisboa (Lisboa, Portugal)
2021/07 Adriana M. Capucho, Bernardete F. Melo, Fátima O. Martins, Joana F. Sacramento, Nishan Ramnarain, Phil Miliken, Sílvia V. Conde. (2021) Carotid body modulation decreases weight gain and improves metabolic function in the rat by impacting feeding behaviour and hypothalamic satiety pathways. Physiology 2021
2021/06 Sacramento JF, Falvey A, Melo BF, Conde SV, Blancou P. (2021) Impact of carotid sinus nerve resection on glucose homeostasis and weight gain in mice: is there a role for b2-adrenergic signalling? Physiology 2021
2021/01 Sacramento JF, Melo BF, Olea E, Obeso A, Rocher A, Rodrigues T, Prieto-Lloret J, Yubero S, Monteiro EC, Matafome P, Conde SV. (2020) Hyperinsulinemia is a major contributor to insulin resistance in chronic intermittent hypoxia, independently of obesity. Seizième Colloque Scientifique Étudiant de la Société Legallois Pour L’Étude du Contrôle Respiratoire. Oxford, Quebec, Canada. Seizième Colloque Scientifique Étudiant de la Société Legallois Pour L’Étude du Contrôle Respiratoire.
2021 Adriana M. Capucho, Bernardete F. Melo, Fátima O. Martins, Joana F. Sacramento, Sílvia V. Conde. (2021) Effect of carotid sinus nerve resection on the expression of hypothalamic proteins that regulate satiety pathways in rats submitted to two different hypercaloric diets. 17th Portuguese Congress of Diabetes
Sociedade Portuguesa de Diabetologia
2020/12 Adriana M. Capucho, Bernardete F. Melo, Fátima O. Martins, Joana F. Sacramento, Sílvia V. Conde. (2020) Carotid Sinus Nerve resection impacts the expression of hypothalamic proteins that regulate satiety in an animal model of obesity and type 2 diabetes. EGIR & NAFLD Virtual
2020/09 Carotid body, intermittent hypoxia and metabolism. Symposium: Something new under the sun: metabolic dysfunction in OSA. Symposium Speaker 25th Congress of the European Sleep Research Society. ESRS Virtual Congress 2020.
(Sevilha, Espanha)
2020/02/05 Carotid sinus nerve resection improves weight gain and glucose homeostasis through amelioration of adipose tissue function in mice: is there a role for 2-adrenergic signaling? L Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/02/05 Elucidating the molecular players behind endothelial damage induced by hypercaloric diets in the pulmonary arteries. L Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/02/05 Gender-differences on adenosine receptors mediation of insulin sensitivity. L Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/02/05 Effect of bromocriptine in improving non-alcoholic fatty liver disease in obese animal model of type 2 diabetes. L Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2020/01/17 Hyperinsulinemia is a major contributor to insulin resistance in chronic intermittent hypoxia, independently of obesity. Seizième Colloque Scientifique Étudiant de la Société Legallois Pour L’Étude du Contrôle Respiratoire
(Oxford, Quebec, Canadá)
2019/10/02 Hyperinsulinemia due to altered insulin secretion contributes to insulin resistance in chronic intermittent hypoxia independently of obesity. European Respiratory Society (ERS) International Congress
European Respiratory Society (Madrid, Espanha)
2019/07/08 Adjustments in purinergic metabolismo maintain the contribituion of adenosine and ATP to carotid body chemosensory activity in ageing. Physiology 2019
The Physiological Society (Aberdeen, Reino Unido)
2019/07/08 Carotid sinus nerve improves hepatic function profile in young and old animals with metabolic dysfunctions exacerbated by long-term hypercaloric diet consumption. Physiology 2019
The Physiological Society (Aberdeen, Reino Unido)
2019/05/09 The beneficial effects of carotid sinus nerve resection on obesity and glucose homeostasis are related with adipose tissue browning. EASD-EGIR Meeting - “New Voyages of Discovery Towards Understanding Insulin Action”
European Association for the Study of Diabetes - European Group for the Study of Insulin Resistance (EGIR) (Lisbon, Portugal)
2019/05/09 Tissue-dependent role of adenosinergic system on insulin resistance. EASD-EGIR Meeting - “New Voyages of Discovery Towards Understanding Insulin Action”
European Association for the Study of Diabetes - European Group for the Study of Insulin Resistance (EGIR) (Lisbon, Portugal)
2019/05/08 Carotid sinus nerve denervation ameliorates and decreases lipid accumulation in the liver in aged animals and in animals with metabolic dysfunction exacerbated by long-term hypercalorc diet consumption. 7th EASD NAFLD Study Group Meeting - “NAFLD/NASH Progression, New Frontiers and Controversies”
European Association for the Study of Diabetes - NAFLD Study Group (Lisbon, Portugal)
2019/03/08 Os efeitos benéficos da desnervação do nervo do seio carotídeo na obesidade e na homeostasia da glucose devem-se à indução do browning do tecido adiposo. 15th Portuguese Congress of Diabetes Congress
Portuguese Congress of Diabetes (Vilamoura, Portugal)
2019/02 ATP and adenosine are involved in CB over activation in the high-fat diet rats: potential therapeutic for type 2 diabetes. XLIX Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2019/02 Effect of carotid sinus nerve denervation on long-term hyper caloric diet exacerbation of age-induced metabolic dysfunction: focusing on the liver. XLIX Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2019/02 From prediabetes to early-stage type 2 diabetes: role of adenosinergic system on insulin resistance progression in the liver. XLIX Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2018/10 Carotid body chemosensitivity correlates with insulinemia and insulin sensitivity in prediabetic patients. Innovate Competition | iMed
iMed (Lisbon, Portugal)
2018/09/15 Can the modulation of adenosine and/or ATP signaling in the carotid body be used to treat type 2 diabetes? Europhysiology 2018
The Physiological Society (London, Reino Unido)
2018/09/13 Can the modulation of adenosine and/or ATP signaling in the carotid body be used to treat type 2 diabetes? Early Career Physiologists' Symposium (ECPS 2018)
The Physiological Society (London, Reino Unido)
2018/06/23 Bioelectronic neuromodulation of the carotid sinus nerve as a potential therapeutic for type 2 diabetes. I NoTeS Congress - Novel Therapeutic Strategies for Noncommunicable Diseases
(Porto, Portugal)
2018/03 Modulação bioeletrónica da actividade do nervo do seio carotídeo: potencial terapêutica para diabetes tipo 2. 14th Portuguese Congress of Diabetes
Portuguese Diabetes Society (Vilamoura, Portugal)
2018/03 O metabolismo da adenosina no tecido adiposo castanho encontra-se desregulado em modelos animais de diabetes tipo 2 induzidos por dietas hipercalóricas. 14th Portuguese Congress of Diabetes 14th Portuguese Congress of Diabetes
Portuguese Diabetes Society (Vilamoura, Portugal)
2018/02 Role of purines in rat carotid body overactivation induced by high-fat diet. XLVIII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2018/02 Carotid sinus nerve resection ameliorates glucose homeostasis and insulin secretion and action in an animal model of obesity. XLVIII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2018/02 Adenosine metabolism is desregulated in brown adipose tissue in diet-induced type 2 diabetes: effect of carotid sinus nerve resection. XLVIII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2018/02 Leptin effects on ventilation and on carotid body activity are blunted in high fat Wistar rats. XLVIII Annual Meeting of the Portuguese Society of Pharmacology XLVIII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2018/02 Carotid body dysfunction in diet-induced insulin resistance is associated with alterations in its morphology. XLVIII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2018/02 Bilateral carotid sinus nerve resection decreases weight gain and body fat mass in a rat model of obesity. XLVIII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2018/02 Changes in adenosine/nitric oxide signaling pathway are associated with skeletal muscle and liver insulin resistance. XLVI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2017/07/24 Overactivation of carotid sinus nerve activity in high-fat animals is mediated by A2 adenosine receptors. 20th International Society for Arterial Chemoreception (ISAC) Congress
International Society for Arterial Chemoreception (Baltimore, Estados Unidos)
2017/07/24 Carotid Sinus Nerve Resection Decreases Weight Gain and Fat Mass in a Rodent Model of Obesity. 20th International Society for Arterial Chemoreception (ISAC) Congress
International Society for Arterial Chemoreception (Baltimore, Estados Unidos)
2017/02 Effect of high-fat diet on carotid sinus nerve activity in basal conditions and in response to hypoxia.  XLVII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2017/02 Small vessels endothelial function and diabetes onset.  XLVII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2016/12/14 Micro Computed Tomography detects changes in liver density in control and in prediabetes rats. International Conference on Advanced Research in Sustainable and Intelligent Manufacturing
Centre for Rapid and Sustainable Product Development and International Conference for Biodigital Architecture & Genetics (Leiria, Portugal)
2016/08/17 Temporal Structure of Glucose Modulation of Carotid Sinus Nerve Activity in vivo. 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
IEEE Engineering in Medicine and Biology Society (Orlando, Estados Unidos)
2016/03 Efeito da ressecção do nervo do seio carotídeo no transporte da glucose em modelos animais de resistência à insulina. 12nd Portuguese Congress of Diabetes
Portuguese Diabetes Society (Vilamoura, Portugal)
2016/03 Resistência à insulina na Apneia Obstrutiva do Sono: o papel do HIF-1a e HIF-2a. 12nd Portuguese Congress of Diabetes
Portuguese Diabetes Society (Vilamoura)
2016/02 Is the effect of carotid sinus nerve resection on insulin sensitivity mediated by an increase in glucose uptake? XLVI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2016/02 Insulin resistance is associated with distinct regulation of HIF-1 and HIF-2 during mild chronic intermittent hypoxia. XLVI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2016/02 Chronic caffeine intake restores insulin sensitivity in high-sucrose diet rats through adaptations in adipose tissue. XLVI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2016/02 Alterations in adenosine metabolism and adenosine receptors expression are associated with insulin resistance. XLVI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2015/11/26 Decreased endogenous insulin production improves whole-body insulin sensitivity: is this a sympathetically mediated effect?   International Society for Autonomic Neuroscience (ISAN) Congress
International Society for Autonomic Neuroscience (Stressa, Itália)
2015/09/26 Insulin resistance: A new consequence of altered carotid body chemoreflex? ? International Society for Autonomic Neuroscience (ISAN) Congress
? International Society for Autonomic Neuroscience (Stressa, Itália)
2015/02 Are the effects of chronic caffeine administration on insulin sensitivity in rats mediated by adenosine receptors? XLV Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2015/02 Does adenosine modulate nitric oxide production in insulin-sensitive tissues? XLV Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2015/02 Unraveling the molecular mechanisms involved in chronic intermittent hypoxia-induced insulin resistance. XLV Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2015/02 Alterations in adenosine receptor expression in skeletal muscle mediate the prevention of insulin resistance induced by adenosine antagonists in high sucrose diet animals. XLV Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2015/02 Establishing the caffeine dose that chronically restores insulin sensitivity in animal model of prediabetes. XLV Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2014/12/01 Unraveling the molecular mechanisms involved in chronic intermittent hypoxia-induced insulin resistance. Hypoxia, molecular mechanisms and clinical translation.
Instituto de Biomedicina de Sevilla – IBiS (Sevilha, Espanha)
2014/06 Elucidating the mechanism by which carotid sinus nerve resection restores insulin sensitivity in pre-diabetes animal models. 19th International Society for Arterial Chemoreception (ISAC) Congress
International Society for Arterial Chemoreception (Leeds, Reino Unido)
2014/02 Nitric oxide is involved in the effects of acute caffeine administration on insulin sensitivity. XLIV Annual Meeting of the Portuguese Society of Pharmacology XLIV Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2014/02 Are the effects of carotid sinus nerve resection on insulin sensitivity mediated by an increase in Glut4 expression in skeletal muscle? XLIV Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2014/02 Effect of carotid sinus nerve denervation on body weight, total fat, visceral fat and lipid profile in diet induced-insulin resistant and hypertensive rats. XLIV Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2014 Treating diabetes by targeting the peripheral nervous system: Bioelectronic Medicines. CDRsp-Instituto Politécnico de Leiria
Instituto Politécnico de Leiria (Marinha Grande, Portugal)
2014 Carotid sinus nerve resection avoids weight gain and reverses dyslipidemia in metabolic syndrome and prediabetes animal models. Fundação Astrazeneca Innovate Competition, iMed Conference 6.0® iMed Conference 6.0®
iMed (Lisbon, Portugal)
2014 Establishing the caffeine dose that chronically restores insulin sensitivity in animal model of prediabetes. iMed Conference 6.0®
iMed (Lisbon, Portugal)
2014 Effect of acute caffeine administration on glucose homeostasis and blood pressure. 2nd IPLeiria International Health Congress, “Challenges & Innovation in Health"
Instituto Politécnico de Leiria (Leiria, Portugal)
2013/07 Dysfunction chemoreceptors: cause or consequence of the sympoms of cardiorespiratory disease? 37th Congress of International Union of Physiological Societies
International Union of Physiological Societies (Birmingham, Reino Unido)
2013/02 Adenosine receptors mediate acute caffeine action on insulin sensitivity in Wistar rats. XLIII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2013/02 Carotid body is involved in the development of insulin resistance in Wistar rats: an effect mediated by sympathetic activation. XLIII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)
2012/10 Chronic carotid sinus nerve resection prevents insulin resistance in diet-induced insulin resistance rats. 48th Annual Meeting of the European Association for the Study of Diabetes
European Association for the Study of Diabetes (Berlin, Alemanha)
2012/07 The effect of acute caffeine administration on insulin sensitivity is mediated by A1 and A2B adenosine receptors. 6th European Congress of Pharmacology
Federation of European Pharmacological Societies (EPHAR) (Granada, Espanha)
2012/03 Chronic caffeine intake increases skeletal muscle Glut4 but not AMPK expression in aged rats. 10th Portuguese Congress of Diabetes
Portuguese Society of Diabetes (Vilamoura, Portugal)
2012/02 Chronic caffeine intake reverses age-induced insulin resistance in the rat. XLII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)
2012/02 Effect of chronic caffeine administration on plasma catecholamines and on skeletal muscle expression of Glut-4 transporters and AMPK in diet-insuced insulin ressitance rats. XLII Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisbon, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2025/01/16 - Atual Does the abolishment of carotid body activity in obese dysmetabolic mothers prevents the dysmetabolic phenotype in the offspring?
Orientador de Ana Catarina Murgeiro
 Cellular and Molecular Biology (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/09 - Atual FUNCTIONAL CHARACTERIZATION OF THE ADENOSINERGIC SYSTEM IN THE PROGRESSION OF HUMAN ADIPOSE TISSUE DYSFUNCTION IN OBESITY
Coorientador de Ana Francisca Duro
 Biochemistry for Health (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022 - Atual Carotid body: linking overnutrition with transgerationallity in dysmetabolism.
Coorientador de Gonçalo Melo
 International Doctoral Programme in Health Sciences (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/01 - 2024/06 Impact of gestational chronic intermittent hypoxia (CIH) on liver function in the offspring.
Coorientador de Margarida Almeida
 Cellular and Molecular Biology (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/02 - 2023/07 Can carotid body modulation ameliorate non-alcoholic fatty liver disease?
Coorientador de Maria Inês Fernandes
 Cellular and Molecular Biology (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/02/01 - 2022/07/09 Impact of high-fat diet in expression of adenosina and ATP receptors in the carotid body.
Orientador de Rodrigo Martins
 Molecular and Cell Biology (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/02/01 - 2021/07/31 Which factors contribute to the development of insulin resistance in obstructive sleep apnea?
Coorientador de Marta Martins
 Bioquímica (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/01/23 - 2020/07 Angiogenesis and insulin resistance: what is the role of A1 adenosine receptors
Coorientador de Leonor Neves
 Undergraduate Programme in Biochemistry (Licenciatura/Bacharelato)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/03/02 - 2020/04/30 Será a hiperinsulinémia o fator que mais contribui para o desenvolvimento da resistência à insulina na apneia obstrutiva do sono, independentemente da obesidade?
Coorientador de Letícia Garcia Naben
 Master in Medicine (Mestrado)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2018/09/01 - 2019/11 Long-term hypercaloric diet consumption exacerbates age-induced metabolic dysfunction: beneficial effects of CSN denervation.
Coorientador de Cláudia Batista
 Biochemistry for Health (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2024/02/07 - 2024/02/09 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology (2024/02/07 - 2024/02/09)
Congresso (Membro da Comissão Organizadora)
 Sociedade Portuguesa de Farmacologia, Portugal
2022/06/27 - 2022/06/30 XXIth Meeting of the International Society of Arterial Chemoreception (2022/06/27 - 2022/06/30)
Congresso (Membro da Comissão Organizadora)
2018/02/05 - 2018/02/05 "First Meeting of Young Portuguese Pharmacologists: Pharmacology Designed for the Future." in XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia/XXXVI Reunião de Farmacologia Clínica/XVII Reunião de Toxicologia (2018/02/05 - 2018/02/05)
Encontro (Membro da Comissão Organizadora)
 Sociedade Portuguesa de Farmacologia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2024/11/19 - 2024/11/19 “Let’s talk about diabetes”
Mesa-redonda
 Roundtable “Let’s talk about diabetes”
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/10/22 - 2024/10/22 Bringing people with diabetes closer to research
Outro
 Bringing people with diabetes closer to research
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

European Animal Research Association, Reino Unido
2024/09/27 - 2024/09/27 European Researchers’ Night - “Sugars, physical activity and our health”
Outro
 European Researchers’ Night
Pavilhão do Conhecimento-Centro Ciência Viva, Portugal
2024/07 - 2024/07 Workshop in the Summer Medical School: Lifestyle
Oficina (workshop)
 Summer Medical School: Lifestyle
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2024/03/13 - 2024/03/19 Brain Awareness Week - “Can we keep our brains healthy to live better and longer?”.
Outro
 Brain Awareness Week
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2023/09 - 2023/09 European Researchers’ Night
Outro
 European Researchers’ Night
Fundação Champalimaud, Portugal
2023 - 2023 JORTEC’23 (Jornadas Tecnológicas) speedmeeting with the students of the undergraduate programme on Cell Molecular Biology and Biochemistry
Outro
 JORTEC’23
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/09 - 2022/09 European Researchers’ Night
Outro
 European Researchers’ Night
Pavilhão do Conhecimento-Centro Ciência Viva, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/10/04 ALTERAÇÕES HISTOFISIOLÓGICAS INDUZIDAS PELA INIBIÇÃO DE HIF EM ANIMAIS TRATADOS COM LUTEOLIM
Arguente
 Bolival Apparecido Mendonça Junior (Doutoramento)
Universidade Federal de Sao Paulo Escola Paulista de Medicina, Brasil
2023/12/07 IMPACTO DA ADMINISTRAÇÃO DE ESTRADIOL NAS ALTERAÇÕES METABÓLICAS, CARDIOVASCULARES E INTRACRANIANAS INDUZIDAS PELO CONSUMO DE DIETA HIPERLIPÍDICA EM RATAS OVARIECTOMIZADAS
Arguente principal
 Marcos Vinicius Fernandes Silva Masalskas (Doutoramento)
Universidade de São Paulo, Brasil
2023/07 Quemerina e adiponectina: novos biomarcadores de patologias associadas com a resistência à insulina
Arguente
 Raquel Soares Pereira (Outro)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2024 - 2024 54th Meeting of the Portuguese Society of Pharmacology, Lisboa, Portugal
2022 - 2022 XXIth Meeting da International Society of Arterial Chemoreception (ISAC) Lisboa

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2023/03/09 - Atual The Journal of Physiology (1469-7793)
2023 - Atual Frontiers in Physiology Frontiers
2020 - Atual Nutrients (2072-6643) MDPI
2021 - 2021 Reviews in Endocrine and Metabolic Disorders
2021 - 2021 International Journal of Molecular Sciences
2020/02 - 2020/03 Journal of Food Biochemistry (1745-4514) Wiley (Blackwell Publishing)
2018/04 - 2018/06 Frontiers in Physiology (1664-042X) Frontiers Media SA
2015/10 - 2015/11 Journal of Basic and Clinical Physiology and Pharmacology (2191-0286) Walter de Gruyter GmbH

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021 - Atual Pharmacology Nutrition Sciences (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - Atual Aging and age-related disease: From molecular mechanisms to therapies NOVA Biomedical Research (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2020 General Pharmacology Integrated Master Degree in Medicine (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2024/01 - Atual Podcast O Futuro do Futuro

Membro de associação

Nome da associação Tipo de participação
2024/02/01 - Atual European Society for Clinical Investigation (ESCI) member
2021 - Atual Sociedade Portuguesa de Fisiologia Member
2020 - Atual European Sleep Research Society Student Membership
2018 - Atual The Physiological Society Affiliate Member
2016 - Atual Portuguese Society of Laboratory Animal Sciences Student Member
2014 - Atual Portuguese Society of Diabetology Member
2014 - Atual Portuguese Society of Pharmacology Student Member
2012 - Atual European Association for the Study of Diabetes Student

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023/09 - 2024/11 Member of the Postdoc Committee
Membro
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Distinções

Prémio

2023 L'Oréal Portugal Medals of Honor for Women in Science
L'Oréal Portugal, Portugal
2022 Pedro Eurico Lisboa honorable mention - Best publication in Diabetes field published in 2021
Sociedade Portuguesa de Diabetologia, Portugal
2021 Award Pedro Eurico Lisboa to the best paper in the Diabetes field
Sociedade Portuguesa de Diabetologia, Portugal
2020 Best Poster - Portuguese Society of Diabetology Congress
Sociedade Portuguesa de Diabetologia, Portugal
2019 Pulido Valente Ciência 2018 Award
2019 Pedro Eurico Lisboa honorable mention - Best publication in Diabetes field published in 2018
Sociedade Portuguesa de Diabetologia, Portugal
2019 Nuno Castelo Branco
Sociedade Portuguesa de Diabetologia, Portugal
2018 Pedro Eurico Lisboa (Best publication in Diabetes field published in 2017)
Sociedade Portuguesa de Diabetologia, Portugal

Lilly Portugal, Portugal
2017 Fernando de Castro ISAC Trainee Award for Excellence in Science Related to Peripheral Arterial Chemoreceptors
2016 Professor Manuel Hargreaves Award
Sociedade Portuguesa de Diabetologia, Portugal

Novartis Farma SA, Portugal
2012 Hargreaves Award 2012
Sociedade Portuguesa de Diabetologia, Portugal

Jaba Recordati SA, Portugal

Outra distinção

2024 Travel AWARD
Sociedade Portuguesa de Fisiologia, Portugal
2019 Junior Research at Scientific Employment Stimulus 2018 Call
Fundação para a Ciência e a Tecnologia, Portugal
2018 Albert Renold Travel Fellowship
European Foundation for the Study of Diabetes, Alemanha
2014 Scholarship for the 2nd DZD Diabetes Research School
Deutsches Diabetes-Zentrum Leibniz-Zentrum für Diabetes-Forschung, Alemanha
2013 Scholarship and travel award recognition for the Summer School in Neuroendocrinology
Federation of European Neuroscience Societies, Bélgica
2013 Grant to participate in the XII International Symposium on Insulin Receptor and Insulin Action, Barcelona, Spain.
Deutsches Diabetes-Zentrum Leibniz-Zentrum für Diabetes-Forschung, Alemanha
2013 Scholarship for the 1st DZD Diabetes Research School
Deutsches Diabetes-Zentrum Leibniz-Zentrum für Diabetes-Forschung, Alemanha