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Andrew Phillip West. Published 26 articles in journals. Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Immunology.
Identificação

Identificação pessoal

Nome completo
Andrew Phillip West

Nomes de citação

  • West, Andrew

Identificadores de autor

Ciência ID
071C-2FD2-A175
ORCID iD
0000-0003-2884-6895

Telefones

Telefone
  • (1) 9794360870 (Profissional)

Moradas

  • 8447 Riverside Parkway, MREB 1 3012, 77807, BRYAN, Texas, Estados Unidos (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
Formação
Grau Classificação
2004/09/15 - 2011/05/15
Concluído
 Immunobiology (Doktor (PhD))
Especialização em Immunobiology
Yale University Graduate School of Arts and Sciences, Estados Unidos
"Exploring the Role of ECSIT in Innate Immune Responses" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/08/01 - Atual Investigador principal (carreira) (Investigação) Texas A&M University College of Medicine, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2017/08 - Atual Mitochondrial DNA Instability Engages a Cancer-Related Interferon Program to Modify the Immune Microenvironment and NAD+ Metabolome and Enhance Melanoma Growth
RP170734
 Cancer Prevention and Research Institute of Texas
2015/05 - 2024/06 The Metabolic Basis of Cancer-Related Fatigue
R01CA193522
 National Cancer Institute
2015/10 - 2016/09 Innate Immune Signaling and Type I Interferon Responses as Novel Modifiers of Mitochondrial Disease Pathology
W81XWH-17-1-0052
 Congressionally Directed Medical Research Programs
2015/10 - 2016/09 Mitochondrial Dysfunction and Aberrant Immune Activation in the Pathobiology of Gulf War Illness
W81XWH-17-1-0446
 Congressionally Directed Medical Research Programs
Produções

Publicações

Artigo em revista
  1. West, Andrew. "Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease.". Neurogenetics (2020): https://doi.org/10.1007/s10048-020-00609-2.
    10.1007/s10048-020-00609-2
  2. West, Andrew. "Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.". eLife (2019): https://doi.org/10.7554/eLife.51031.
    10.7554/elife.51031
  3. West, Andrew. "Mitochondrial DNA stress signalling protects the nuclear genome". Nature Metabolism (2019): http://dx.doi.org/10.1038/s42255-019-0150-8.
    10.1038/s42255-019-0150-8
  4. West, Andrew. "Impact of pharmacological agents on mitochondrial function: a growing opportunity?". Biochemical Society transactions (2019): https://doi.org/10.1042/BST20190280.
    10.1042/bst20190280
  5. West, Andrew. "The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages.". Cell reports (2019): https://doi.org/10.1016/j.celrep.2019.09.078.
    10.1016/j.celrep.2019.09.078
  6. West, Andrew. "A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.". Nature (2019): https://doi.org/10.1038/s41586-019-1228-x.
    10.1038/s41586-019-1228-x
  7. West, Andrew. "Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma.". Scientific reports (2018): http://europepmc.org/articles/PMC6155108.
    10.1038/s41598-018-31170-6
  8. West, Andrew. "A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis.". PLoS biology (2018): http://europepmc.org/articles/PMC6072105.
    10.1371/journal.pbio.2005796
  9. West, Andrew. "Editorial.". Mitochondrion (2018): https://doi.org/10.1016/j.mito.2018.05.002.
    10.1016/j.mito.2018.05.002
  10. West, Andrew. "cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.". Nature medicine (2017): http://europepmc.org/articles/PMC5760363.
    10.1038/nm.4450
  11. West, Andrew. "Mitochondrial dysfunction as a trigger of innate immune responses and inflammation.". Toxicology (2017): https://doi.org/10.1016/j.tox.2017.07.016.
    10.1016/j.tox.2017.07.016
  12. West, Andrew. "Mitochondrial DNA in innate immune responses and inflammatory pathology.". Nature reviews. Immunology (2017): https://doi.org/10.1038/nri.2017.21.
    10.1038/nri.2017.21
  13. West, Andrew. "Mitochondrial DNA stress primes the antiviral innate immune response.". Nature (2015): http://europepmc.org/articles/PMC4409480.
    10.1038/nature14156
  14. West, Andrew. "Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination.". Aging (2015): http://europepmc.org/articles/PMC4356402.
    10.18632/aging.100720
  15. West, Andrew. "Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.". Cell (2014): http://europepmc.org/articles/PMC4272443.
    10.1016/j.cell.2014.11.037
  16. West, Andrew. "MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury.". American journal of physiology. Lung cellular and molecular physiology (2014): http://europepmc.org/articles/PMC3962628.
    10.1152/ajplung.00272.2013
  17. West, Andrew. "Mitochondria in innate immune responses.". Nature reviews. Immunology (2011): http://europepmc.org/articles/PMC4281487.
    10.1038/nri2975
  18. West, Andrew. "TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.". Nature (2011): http://europepmc.org/articles/PMC3460538.
    10.1038/nature09973
  19. West, Andrew. "IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response.". Nature (2010): http://europepmc.org/articles/PMC2946371.
    10.1038/nature09283
  20. West, Andrew. "Subversion of innate immune responses by Brucella through the targeted degradation of the TLR signaling adapter, MAL.". Journal of immunology (Baltimore, Md. : 1950) (2009): http://europepmc.org/articles/PMC3644118.
    10.4049/jimmunol.0902008
  21. West, Andrew. "SnapShot: NF-kappaB signaling pathways.". Cell (2006): https://doi.org/10.1016/j.cell.2006.12.005.
    10.1016/j.cell.2006.12.005
  22. West, Andrew. "NF-kappaB and the immune response.". Oncogene (2006): https://doi.org/10.1038/sj.onc.1209943.
    10.1038/sj.onc.1209943
  23. West, Andrew. "Recognition and signaling by toll-like receptors.". Annual review of cell and developmental biology (2006): https://doi.org/10.1146/annurev.cellbio.21.122303.115827.
    10.1146/annurev.cellbio.21.122303.115827
  24. West, Andrew. "Gangliosides inhibit flagellin signaling in the absence of an effect on flagellin binding to toll-like receptor 5.". The Journal of biological chemistry (2005): https://doi.org/10.1074/jbc.M411875200.
    10.1074/jbc.m411875200
  25. West, Andrew. "Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes.". Journal of immunology (Baltimore, Md. : 1950) (2003): https://doi.org/10.4049/jimmunol.170.12.6217.
    10.4049/jimmunol.170.12.6217
  26. West, Andrew. "Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin.". The Journal of biological chemistry (2003): https://doi.org/10.1074/jbc.M303481200.
    10.1074/jbc.m303481200