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Dr. Colin Adrain is a tenured Senior Lecturer and Principal Investigator at the Patrick G Johnston Centre for Cancer Research, in Queen's University Belfast, Ireland and is head of the Membrane Traffic Lab at Instituto Gulbenkian de Ciência. Adrain is an Editorial Board Member of the FEBS Journal and is also Commissioning Editor at the FEBS Journal. He has published 39 articles in journals and has published two book chapters. Adrain has been a co-organizer of two EMBO workshops on Proteostasis (2017 and 2019) in Portugal. As Principal investigator he participates in/has participated in 6 projects. Before becoming an independent PI, Adrain was a Postdoctoral fellow in the MRC Laboratory of Molecular Biology (MRC-LMB) in Cambridge, UK, under the mentorship of Prof. Matthew Freeman. Adrain completed a PhD (Molecular Cell Biology) in 2003 in the Smurfit Institute of Genetics, Trinity College Dublin, Ireland, under the mentorship of Prof. Seamus Martin. He obtained a BSc (1st Class Hons) in Genetics in 1997 from the School of Biological Sciences Queen Mary College, University of London, U.K. Research in the Adrain lab focuses on proteostasis (protein homeostasis) at the endoplasmic reticulum (ER) and its impact on membrane protein trafficking, metabolism and cell signaling. His lab combines mouse genetics/physiology with molecular cell biology and biochemistry. Current projects undergoing in the lab include: -Physiological role of the EMC (ER Membrane Complex) in membrane protein biogenesis and organismal physiology. -Regulation of metabolism by membrane trafficking and protein quality control in the secretory pathway. -Regulation of the trafficking and activation of the metalloprotease ADAM17 by its trafficking regulators iRhom/iTAP, in response to inflammatory and growth-promoting stimuli.
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Identificação

Identificação pessoal

Nome completo
Colin Adrain

Nomes de citação

  • Adrain, Colin

Identificadores de autor

Ciência ID
0919-A2C7-E200
ORCID iD
0000-0001-7597-4393

Endereços de correio eletrónico

  • c.adrain@qub.ac.uk (Profissional)
  • c.adrain@qub.ac.uk (Profissional)

Telefones

Telefone
  • (0044) 7464806615 (Pessoal)
Telemóvel
  • 935804541 (Pessoal)

Moradas

  • Patrick G. Johnston Centre for Cancer Research, 97 Lisburn Road., BT9 7AE, Belfast, Co Antrim, Reino Unido (Profissional)
  • Instituto Gulbenkian de Ciência, Rua da Quinta Grande, no.6, 2780-156, Oeiras, Oeiras, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Português Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Italiano Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Irlandês Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador independente (B1) Utilizador elementar (A2)
Formação
Grau Classificação
1998/01/01 - 2003/07/11
Concluído
 PhD (Molecular Cell Biology) (Doctor of Philosophy)
Smurfit Institute of Genetics Trinity College, Irlanda
"An investigation of the role of Caspase-9-interacting proteins in the molecular control of apoptosis" (TESE/DISSERTAÇÃO)
1994/01/09 - 1997/06/30
Concluído
 B.Sc. 1st Class Honours degree in Genetics (Bachelor) (Bachelor)
Queen Mary University of London School of Biological and Chemical Sciences, Reino Unido
 1st Class Hons
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/01/01 - Atual Investigador principal (carreira) (Investigação) Queen's University Belfast Centre for Cancer Research & Cell Biology, Reino Unido
Queen's University Belfast Centre for Cancer Research & Cell Biology, Reino Unido
2013/06/01 - 2021/12/31 Investigador principal (carreira) (Investigação) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/02/01 - 2013/05/01 Postdoctoral Fellow MRC Laboratory of Molecular Biology, Reino Unido
2003/07/01 - 2006/02/01 Postdoctoral Fellow Smurfit Institute of Genetics Trinity College, Irlanda
1998/10/01 - 2003/07/01 PhD Student Smurfit Institute of Genetics Trinity College, Irlanda
1997/10/01 - 1998/10/01 Research Assistant National University of Ireland Maynooth Institute of Bioengineering and Agroecology, Irlanda
Projetos

Bolsa

Designação Financiadores
2018/11/01 - 2021/10/31 LCF/PR/HR17/52150018 Organismal role of the ER membrane complex: a conserved machinery required for membrane protein biogenesis.
LCF/PR/HR17/52150018
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
 Obra Social La Caixa
Em curso
2018/07/01 - 2021/06/30 Role of iTAP, a novel regulator of ADAM17, in regulation of cellular proliferation and cancer
LISBOA-01-0145-FEDER-031330
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/01/05 - 2019/04/30 Membrane trafficking control of inflammation
Provided by PTCRIS: 141642
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2014/01 - 2017/12 Intramembrane proteolysis and disease (IPAD)
PCIG13-GA-2013-618769 - IPAD
 Marie Curie Actions
2014/09 - 2017/08 iRhom regulation and control of EGFR signaling
14-1289
 Association for International Cancer Research
2014/05 - 2015/04 Role of rhomboid-like proteins in intestinal damage and repair
n/a
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
 European Crohn's and Colitis Organisation
Concluído
2006/05 - 2009/04 Identification and genetic validation of novel substrates of the rhomboid intramembrane proteases
HFSPLTFLTF20061
 Human Frontiers Science Program
Produções

Publicações

Artigo em revista
  1. Julia D. Knopf; Susanne S. Steigleder; Friederike Korn; Nathalie Kühnle; Marina Badenes; Marina Tauber; Sebastian J. Theobald; et al. Autor correspondente: Marius K. Lemberg. "RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling". Nature Communications (2024):
    Aceite para publicação
  2. Gaspar, Catarina J.; Gomes, Tiago; Martins, Joana C.; Melo, Manuel N.; Adrain, Colin; Cordeiro, Tiago N.; Domingos, Pedro M.. "Xport-A functions as a chaperone by stabilizing the first five transmembrane domains of rhodopsin-1". iScience 26 12 (2023): 108309. http://dx.doi.org/10.1016/j.isci.2023.108309.
    10.1016/j.isci.2023.108309
  3. Amin, Abdulbasit; Badenes, Marina; Tüshaus, Johanna; de Carvalho, Érika; Burbridge, Emma; Faísca, Pedro; Trávnícková, Kveta; et al. "Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis". Molecular Metabolism 73 (2023): 101731. http://dx.doi.org/10.1016/j.molmet.2023.101731.
    10.1016/j.molmet.2023.101731
  4. Badenes, Marina; Burbridge, Emma; Oikonomidi, Ioanna; Amin, Abdulbasit; de Carvalho, Érika; Kosack, Lindsay; Mariano, Camila; et al. "The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth". Life Science Alliance 6 4 (2023): e202201644. http://dx.doi.org/10.26508/lsa.202201644.
    10.26508/lsa.202201644
  5. Emma Burbridge; Colin Adrain. "Organelle homeostasis: from cellular mechanisms to disease". The FEBS Journal (2022): https://doi.org/10.1111/febs.16667.
    10.1111/febs.16667
  6. Li, Xianhe; Straub, Julian; Medeiros, Tânia Catarina; Mehra, Chahat; den Brave, Fabian; Peker, Esra; Atanassov, Ilian; et al. "Mitochondria shed their outer membrane in response to infection-induced stress". Science 375 6577 (2022): http://dx.doi.org/10.1126/science.abi4343.
    Publicado • 10.1126/science.abi4343
  7. Catarina J Gaspar; Lígia C Vieira; Cristiana C Santos; John C Christianson; David Jakubec; Kvido Strisovsky; Colin Adrain; Pedro M Domingos. "EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel". EMBO reports (2022): https://doi.org/10.15252/embr.202153210.
    10.15252/embr.202153210
  8. Colin Adrain. "Systemic and cellular metabolism: the cause of and remedy for disease?". The FEBS Journal (2021): https://doi.org/10.1111/febs.16033.
    10.1111/febs.16033
  9. Colin Adrain; Miguel Cavadas. "The complex life of rhomboid pseudoproteases". The FEBS Journal 287 19 (2020): 4261-4283. https://doi.org/10.1111/febs.15548.
    10.1111/febs.15548
  10. Marina Badenes; Colin Adrain. "iRhom2 and TNF: Partners or enemies?". Science Signaling (2019): https://doi.org/10.1126/scisignal.aaz0444.
    10.1126/scisignal.aaz0444
  11. Adrain, Colin. "Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis". Molecular Metabolism (2019): http://dx.doi.org/10.1016/j.molmet.2019.10.006.
    10.1016/j.molmet.2019.10.006
  12. Ioanna Oikonomidi; Emma Burbridge; Miguel Cavadas; Graeme Sullivan; Blanka Collis; Heike Naegele; Danielle Clancy; et al. "iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE". eLife 7 (2018): https://pure.qub.ac.uk/en/publications/itap-a-novel-irhom-interactor-controls-tnf-secretion-by-policing-the-stability-of-irhomtace(50eeec4b-25ce-48a6-a6c8-beca9bae70c6).html.
    10.7554/eLife.35032
  13. Adrain, Colin; Henis-Korenblit, Sivan; Domingos, Pedro M.. "Meeting Report – proteostasis in Ericeira". Journal of Cell Science 131 5 (2018): http://dx.doi.org/10.1242/jcs.216150.
    10.1242/jcs.216150
  14. Clemente T; Vieira NJ; Cerliani JP; Adrain C; Luthi A; Dominguez MR; Yon M; et al. "Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery.". Cell death & disease (2017): http://europepmc.org/abstract/med/29215607.
    10.1038/cddis.2017.506
  15. Johnson, N.; Brezinová, J.; Stephens, E.; Burbridge, E.; Freeman, M.; Adrain, C.; Strisovsky, K.. "Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85026813056&partnerID=MN8TOARS.
    10.1038/s41598-017-07556-3
  16. Cavadas, M.; Oikonomidi, I.; Gaspar, C.J.; Burbridge, E.; Badenes, M.; Félix, I.; Bolado, A.; et al. "Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE". Cell Reports 21 3 (2017): 745-757. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032011945&partnerID=MN8TOARS.
    10.1016/j.celrep.2017.09.074
  17. Wunderle, L.; Knopf, J.D.; Kühnle, N.; Morle, A.; Hehn, B.; Adrain, C.; Strisovsky, K.; Freeman, M.; Lemberg, M.K.. "Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFa". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84974588699&partnerID=MN8TOARS.
    10.1038/srep27342
  18. Lemberg, M.K.; Adrain, C.. "Inactive rhomboid proteins: New mechanisms with implications in health and disease". Seminars in Cell and Developmental Biology 60 (2016): 29-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-84997456810&partnerID=MN8TOARS.
    10.1016/j.semcdb.2016.06.022
  19. Adrain, C.; Freeman, M.. "Regulation of receptor tyrosine kinase ligand processing". Cold Spring Harbor Perspectives in Biology 6 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891646642&partnerID=MN8TOARS.
    10.1101/cshperspect.a008995
  20. Christova, Y.; Adrain, C.; Bambrough, P.; Ibrahim, A.; Freeman, M.. "Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation". EMBO Reports 14 10 (2013): 884-890. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885320661&partnerID=MN8TOARS.
    10.1038/embor.2013.128
  21. Adrain, C.; Freeman, M.. "New lives for old: Evolution of pseudoenzyme function illustrated by iRhoms". Nature Reviews Molecular Cell Biology 13 8 (2012): 489-498. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864279894&partnerID=MN8TOARS.
    10.1038/nrm3392
  22. Adrain, C.; Zettl, M.; Christova, Y.; Taylor, N.; Freeman, M.. "Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE". Science 335 6065 (2012): 225-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855822415&partnerID=MN8TOARS.
    10.1126/science.1214400
  23. Adrain, C.; Strisovsky, K.; Zettl, M.; Hu, L.; Lemberg, M.K.; Freeman, M.. "Mammalian EGF receptor activation by the rhomboid protease RHBDL2". EMBO Reports 12 5 (2011): 421-427. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955526700&partnerID=MN8TOARS.
    10.1038/embor.2011.50
  24. Zettl, M.; Adrain, C.; Strisovsky, K.; Lastun, V.; Freeman, M.. "Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling". Cell 145 1 (2011): 79-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953269767&partnerID=MN8TOARS.
    10.1016/j.cell.2011.02.047
  25. Adrain, C.; Martin, S.J.. "Apoptosis: Calling time on apoptosome activity". Science Signaling 2 91 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-77449158449&partnerID=MN8TOARS.
    10.1126/scisignal.291pe62
  26. Creagh, E.M.; Brumatti, G.; Sheridan, C.; Duriez, P.J.; Taylor, R.C.; Cullen, S.P.; Adrain, C.; Martin, S.J.. "Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival". PLoS ONE 4 3 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-63749094517&partnerID=MN8TOARS.
    10.1371/journal.pone.0005055
  27. Cullen, S.P.; Adrain, C.; Lüthi, A.U.; Duriez, P.J.; Martin, S.J.. "Human and murine granzyme B exhibit divergent substrate preferences". Journal of Cell Biology 176 4 (2007): 435-444. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846946478&partnerID=MN8TOARS.
    10.1083/jcb.200612025
  28. Adrain, C.; Martin, S.J.. "Double knockout blow for caspases". Science 311 5762 (2006): 785-786. http://www.scopus.com/inward/record.url?eid=2-s2.0-32444433620&partnerID=MN8TOARS.
    10.1126/science.1124154
  29. Adrain, C.; Duriez, P.J.; Brumatti, G.; Delivani, P.; Martin, S.J.. "The cytotoxic lymphocyte protease, Granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics". Journal of Biological Chemistry 281 12 (2006): 8118-8125. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646363340&partnerID=MN8TOARS.
    10.1074/jbc.M509361200
  30. Delivani, P.; Adrain, C.; Taylor, R.C.; Duriez, P.J.; Martin, S.J.. "Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics". Molecular Cell 21 6 (2006): 761-773. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644859410&partnerID=MN8TOARS.
    10.1016/j.molcel.2006.01.034
  31. Adrain, C.; Brumatti, G.; Martin, S.J.. "Apoptosomes: protease activation platforms to die from". Trends in Biochemical Sciences 31 5 (2006): 243-247. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646379844&partnerID=MN8TOARS.
    10.1016/j.tibs.2006.03.004
  32. Adrain, C.; Murphy, B.M.; Martin, S.J.. "Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B". Journal of Biological Chemistry 280 6 (2005): 4663-4673. http://www.scopus.com/inward/record.url?eid=2-s2.0-14244260622&partnerID=MN8TOARS.
    10.1074/jbc.M410915200
  33. Taylor, R.C.; Adrain, C.; Martin, S.J.. "Proteases, proteasomes and apoptosis: Breaking Ub is hard to do". Cell Death and Differentiation 12 9 (2005): 1213-1217. http://www.scopus.com/inward/record.url?eid=2-s2.0-23944490171&partnerID=MN8TOARS.
    10.1038/sj.cdd.4401703
  34. Hill, M.M.; Adrain, C.; Duriez, P.J.; Creagh, E.M.; Martin, S.J.. "Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes". EMBO Journal 23 10 (2004): 2134-2145. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942532135&partnerID=MN8TOARS.
    10.1038/sj.emboj.7600210
  35. Twiddy, D.; Brown, D.G.; Adrain, C.; Jukes, R.; Martin, S.J.; Cohen, G.M.; MacFarlane, M.; Cain, K.. "Pro-apoptotic Proteins Released from the Mitochondria Regulate the Protein Composition and Caspase-processing Activity of the Native Apaf-1/Caspase-9 Apoptosome Complex". Journal of Biological Chemistry 279 19 (2004): 19665-19682. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442540299&partnerID=MN8TOARS.
    10.1074/jbc.M311388200
  36. Adrain, C.; Creagh, E.M.; Cullen, S.P.; Martin, S.J.. "Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man". Journal of Biological Chemistry 279 35 (2004): 36923-36930. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344598382&partnerID=MN8TOARS.
    10.1074/jbc.M402638200
  37. Adrain, C.; Creagh, E.M.; Martin, S.J.. "Defying death: Showing Bcl-2 the way home". Nature Cell Biology 5 1 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0037228251&partnerID=MN8TOARS.
    10.1038/ncb0103-9a
  38. Murphy, B.M.; O'Neill, A.J.; Adrain, C.; Watson, R.W.G.; Martin, S.J.. "The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome c". Journal of Experimental Medicine 197 5 (2003): 625-632. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037416139&partnerID=MN8TOARS.
    10.1084/jem.20021862
  39. Hill, M.M.; Adrain, C.; Martin, S.J.. "Portrait of a killer: the mitochondrial apoptosome emerges from the shadows.". Mol Interv 3 1 (2003): 19-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344908231&partnerID=MN8TOARS.
  40. Bouchier-Hayes, L.; Conroy, H.; Egan, H.; Adrain, C.; Creagh, E.M.; MacFarlane, M.; Martin, S.J.. "CARDINAL, a Novel Caspase Recruitment Domain Protein, Is an Inhibitor of Multiple NF-¿B Activation Pathways". Journal of Biological Chemistry 276 47 (2001): 44069-44077. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035941220&partnerID=MN8TOARS.
    10.1074/jbc.M107373200
  41. Adrain, C.; Martin, S.J.. "The mitochondrial apoptosome: A killer unleashed by the cytochrome seas". Trends in Biochemical Sciences 26 6 (2001): 390-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035369143&partnerID=MN8TOARS.
    10.1016/S0968-0004(01)01844-8
  42. Adrain, C.; Creagh, E.M.; Martin, S.J.. "Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2". EMBO Journal 20 23 (2001): 6627-6636. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035803568&partnerID=MN8TOARS.
    10.1093/emboj/20.23.6627
  43. Adrain, C.; Martin, S.J.. "Search for Drosophila caspases bears fruit: STRICA enters the fray". Cell Death and Differentiation 8 4 (2001): 319-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035040769&partnerID=MN8TOARS.
    10.1038/sj.cdd.4400869
  44. Slee, E.A.; Adrain, C.; Martin, S.J.. "Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis". Journal of Biological Chemistry 276 10 (2001): 7320-7326. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035831473&partnerID=MN8TOARS.
    10.1074/jbc.M008363200
  45. Colin Adrain; E A Slee; M T Harte; S J Martin; Adrain, C.; Slee, E.A.; Harte, M.T.; Martin, S.J.. "Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region". Journal of Biological Chemistry 274 30 (1999): 20855-60. https://pure.qub.ac.uk/en/publications/regulation-of-apoptotic-protease-activating-factor1-oligomerization-and-apoptosis-by-the-wd40-repeat-region(b70c5525-fb13-40e5-8ba2-dfb0958f5106).html.
    10.1074/jbc.274.30.20855
  46. Slee, E.A.; Adrain, C.; Martin, S.J.. "Serial killers: Ordering caspase activation events in apoptosis". Cell Death and Differentiation 6 11 (1999): 1067-1074. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032785181&partnerID=MN8TOARS.
Edição de número de revista
  1. Adrain, Colin. "Special Issue on Pseudoenzymes". The FEBS Journal (2020): https://febs.onlinelibrary.wiley.com/toc/17424658/2020/287/19.
    Publicado • Editor convidado
Livro
  1. Adrain, C.; Martin, S.J.. Caspases: Agents of Defense and Destruction. 2008.
    10.1002/9783527619665.ch9
Pré-impressão
  1. Marina Badenes; Emma Burbridge; Ioanna Oikonomidi; Abdulbasit Amin; Érika de Carvalho; Lindsay Kosack; Pedro Domingos; Pedro Faísca; Colin Adrain. "The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth". 2022. https://doi.org/10.1101/2022.04.11.487842.
    10.1101/2022.04.11.487842
Recurso online
  1. Gaspar, Catarina J.; Joana C Martins; Manuel N. Melo; Tiago N Cordeiro; Adrain, Colin; Domingos, Pedro; Catarina J Gaspar; et al. Autor correspondente: Domingos, Pedro. Xport-A functions as a chaperone by stabilizing the first 5 transmembrane domains of Rhodopsin-1. 2022. https://www.biorxiv.org/content/10.1101/2022.04.01.486763v1.
    https://doi.org/10.1101/2022.04.01.486763

Outros

Outra produção
  1. EMC is required for biogenesis and membrane insertion of Xport-A, an essential chaperone of rhodopsin-1 and the TRP channel. Manuscript currently submitted to BioRxiv in advance of journal submission.. 2021. Adrain, Colin. https://www.biorxiv.org/content/10.1101/2021.02.01.429115v1.full.pdf+html.
    doi.org/10.1101/2021.02.01.429115
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/02/02 Role of the ER Membrane Complex (EMC): the complex, greasy, & degrading life of membrane proteins Seminar
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2021/01/20 iRhom proteins and ADAM17: key regulators of growth control & inflammation The Charles Institute Seminar Series
The Charles Institute, University College, Dublin (Dublin , Irlanda)
2020/02/25 iRhom pseudoproteases as metabolic regulators Seminar in Dept. of Biochemistry, University of Cambridge
University of Cambridge (Cambridge, Reino Unido)
2019/10 iRhom proteins integrate inflammation and metabolic regulation
Queen's University, Belfast (Belfast, Reino Unido)
2019/05/15 Regulation of ADAM17 by iRhom pseudoproteases Gordon Metalloproteases Conference, Lucca, May (2019).
(Barga, Itália)
2019/04 Physiological and Molecular Roles of iRhom Proteins in Inflammation and Metabolism Seminar in Dept. of Biochemistry, University of Kiel, Germany.
Stefan Rose John (Kiel, Alemanha)
2018/10/23 A role for Ubxd8 in the regulation of adipose tissue homeostasis EMBO ER meeting, Endoplasmic Reticulum function in health and disease
EMBO (Lucca, Itália)
2018/05 iRhom pseudoproteases and metabolic regulation Pseudoenzymes 2018: From molecular mechanisms to cell biology
EMBO

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2014/01/01 - 2019/05/01 Regulation of cellular signalling by trafficking control Molecular control of proteolysis on the cell surface by the iRhom/TACE sheddase complex
Orientador de Ioanna Oikonomidi
 Biology (Doutoramento)
Instituto Gulbenkian de Ciência, Portugal
2015/01/01 - 2015/12/02 Role of RHBDD2 in Membrane Trafficking Regulation
Coorientador
 Biologia Evolutiva e do Desenvolvimento (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/11/17 - 2023/11/21 2023 EMBO workshop Proteostasis: From translation to degradation (https://meetings.embo.org/event/23-proteostasis) (2023/11/17 - 2023/11/21)
Oficina (workshop) (Coorganizador)
 EMBO (European Molecular Biology Organization), França
2019/11/15 - 2019/11/19 Co-Organizer of EMBO Workshop on Proteostasis: "From Organelles to organisms" https://meetings.embo.org/event/19-proteostasis (2019/11/15 - 2019/11/19)
Congresso (Coorganizador)
 Instituto Gulbenkian de Ciência, Portugal
2017/11/17 - 2017/11/21 Co-organizer of the 2017 EMBO Workshop on Proteostasis in Ericeira, Portugal. https://meetings.embo.org/event/17-proteostasis (2017/11/17 - 2017/11/21)
Congresso (Coorganizador)
 Instituto Gulbenkian de Ciência, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2019 Regulation of iRhom proteins
Arguente principal
 Boris Sieber (Doutoramento)
Sir William Dunn School of Pathology, Reino Unido
2018/04/16 Innate Immunity
Arguente principal
 Katie O'Grady (Doutoramento)
Trinity College Dublin Institute of Molecular Medicine, Irlanda
2017/06/08 Tissue damage control: Protection against necroptosis by the transcription factor NF-E2-related factor 2 (Nrf2)
Arguente
 Ana Martins Ribeiro (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/11/12 Molecular regulation of apoptosis
Arguente principal
 Danielle Clancy (Doutoramento)
Smurfit Institute of Genetics Trinity College, Irlanda
2015/12/16 Modeling Neurodegenerative Diseases in Drosophila
Arguente principal
 Gonçalo Poças (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/06/09 The Role of the Xbp1-dependent Upr Branch in Neurodegeneration
Arguente principal
 Nadine Simone Schweizer (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2014/01/01 - Atual The FEBS Journal, Editorial Board Member (1742-4658)

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2021 - Atual Evaluation of final project reports for FCT
Avaliador
 Fundação para a Ciência e a Tecnologia, Portugal
Distinções

Prémio

2013 Career Integration Grant (CIG)
European Commission Seventh Framework Programme for Research and Technological Development, Bélgica

Outra distinção

2006 Postdoctoral Fellowship (HFSP, LT00846/2006-L).
Human Frontiers Science Program, França
2005 Long-term fellowship (ALTF 972-2005)
EMBO (European Molecular Biology Organization), França