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Identificação

Identificação pessoal

Nome completo
Alan Ramsay

Nomes de citação

  • Ramsay, Alan

Identificadores de autor

Ciência ID
0C15-01CB-7612
ORCID iD
0000-0002-0452-0420

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2013
Concluído
 School of Cancer Sciences, Faculty of Life Sciences & Medicine, King’s College London. (Título de Agregado)
King´s College London, Reino Unido
"Understanding the immune checkpoint network in chronic lymphocytic leukemia and lymphoma to effectively combine immunotherapy with targeted therapy." (TESE/DISSERTAÇÃO)
 Associate Professor and Lymphoma Programme Coordin
2003
Concluído
 BBSRC/CASE (Nestlé UK Ltd) PhD Studentship (Molecular & Cell Biology, Microbiology, Uni. of Aberdeen) (Doutoramento)
University of Aberdeen, Reino Unido
"Studying the molecular biology of novel probiotics for human health" (TESE/DISSERTAÇÃO)
 PhD awarded
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/12/01 - Atual Associate Professor/PI, Team Leader in Lymphoma Biology, Lymphoma Immunology group, Lymphoma Programme Coordinator, School of Cancer Sciences, Faculty of Life Sciences & Medicine, King’s College Londo King´s College London, Reino Unido
2009/10/01 - 2013/11/30 Assistant Professor/PI, Team Leader, Barts Cancer Institute (a CRUK Centre of Excellence), Centre for Haemato-Oncology, Queen Mary University of London (QMUL). Barts Cancer Institute, Queen Mary University of London, Reino Unido
2006/10/01 - 2009/10/30 Senior Postdoctoral Research Assistant with Prof. John G. Gribben, Centre for Haemato-Oncology, Barts Cancer Institute, QMUL. Barts Cancer Institute, Queen Mary University of London, Reino Unido
2003/10/01 - 2006/09/30 Cancer Research UK Postdoctoral Research Fellow with Prof. Ian R. Hart, Centre for Tumour Biology, Barts Cancer Institute, London. Barts Cancer Institute, Reino Unido
1999/10/01 - 2003/09/30 PhD research expedition, Nestlé Research Centre, Lausanne, Switzerland. BBSRC/CASE (Nestlé UK Ltd) PhD Studentship (Molecular & Cell Biology, Microbiology, University of Aberdeen) with Prof. Harry J. University of Aberdeen, Reino Unido
Projetos

Bolsa

Designação Financiadores
2014 - 2022 Investigating the immunomodulatory effects & MOA of combination immunotherapy in CLL and lymphoma.
N/A
Bolseiro de Integração na Investigação
2017 - 2021 Investigating novel immunotherapies and targeting immunosuppressive CAFs in lymphoma.
N/A
Bolseiro de Investigação
Concluído
2015 - 2021 Immunomodulatory correlative science studies (T cell functional studies).
N/A
Bolseiro de Integração na Investigação
2015/05 - 2020/04 Predicting Clinical Outcome After Traditional and Ibrutinib-based Therapy In Chronic Lymphocytic Leukemia
R01CA193541
 National Cancer Institute
2016 - 2020 Understanding how immunomodulatory drugs affect tumour microenvironment (TME)/CAF-driven immune suppression (lymphoma).
N/A
Bolseiro de Integração na Investigação
2015 - 2019 Combinatorial immune checkpoint blockade in B-cell malignancy (CLL, lymphoma).
N/A
Bolseiro de Integração na Investigação
2014/11 - 2018/11 Investigating the immunomodulatory role of cancer-associated fibroblasts (CAFs) in chronic lymphocytic leukemia
14025
 Bloodwise
2016 - 2018 Investigating the stromal/myofibroblast compartment in a DLBCL transgenic mouse model.
N/A
Bolseiro de Integração na Investigação
2014 - 2018 Understanding the immune checkpoint network in chronic lymphocytic leukemia and lymphoma to effectively combine immunotherapy with targeted therapy. Studying FRCs/cancer-associated fibroblasts (CAFs) in diffuse large B-cell lymphoma (DLBCL).
N/A
Bolseiro de Integração na Investigação
Produções

Publicações

Artigo em revista
  1. Vaca, Alicia M.; Ioannou, Nikolaos; Sivina, Mariela; Vlachonikola, Elisavet; Clise-Dwyer, Karen; Kim, Ekaterina; Li, Dan; et al. "Activation and expansion of T-follicular helper cells in chronic lymphocytic leukemia nurselike cell co-cultures". Leukemia (2022): http://dx.doi.org/10.1038/s41375-022-01519-y.
    10.1038/s41375-022-01519-y
  2. Hanna, Bola S.; Llaó-Cid, Laura; Iskar, Murat; Roessner, Philipp M.; Klett, Lara C.; Wong, John K.L.; Paul, Yashna; et al. "Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity". Immunity 54 12 (2021): 2825-2841.e10. http://dx.doi.org/10.1016/j.immuni.2021.11.004.
    10.1016/j.immuni.2021.11.004
  3. Ioannou, Nikolaos; Jain, Khushi; Ramsay, Alan G.. "Immunomodulatory Drugs for the Treatment of B Cell Malignancies". International Journal of Molecular Sciences 22 16 (2021): 8572. http://dx.doi.org/10.3390/ijms22168572.
    10.3390/ijms22168572
  4. Graham, Charlotte Elizabeth; Jozwik, Agnieszka; Quartey-Papafio, Ruby; Ioannou, Nikolaos; Metelo, Ana M.; Scala, Carlo; Dickson, Glenda; et al. "Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma". Leukemia 35 12 (2021): 3581-3584. http://dx.doi.org/10.1038/s41375-021-01324-z.
    10.1038/s41375-021-01324-z
  5. James W Opzoomer; Jessica A Timms; Kevin Blighe; Thanos P Mourikis; Nicolas Chapuis; Richard Bekoe; Sedigeh Kareemaghay; et al. "ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data". eLife 10 (2021): https://doi.org/10.7554/eLife.62915.
    10.7554/eLife.62915
  6. Opzoomer, James W; Timms, Jessica A; Blighe, Kevin; Mourikis, Thanos P; Chapuis, Nicolas; Bekoe, Richard; Kareemaghay, Sedigeh; et al. "ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data". eLife 10 (2021): http://dx.doi.org/10.7554/elife.62915.
    10.7554/elife.62915
  7. Svanberg, Rebecka; Janum, Sine; Patten, Piers E.M.; Ramsay, Alan G.; Niemann, Carsten U.. "Targeting the tumor microenvironment in chronic lymphocytic leukemia". Haematologica 106 9 (2021): 2312-2324. http://dx.doi.org/10.3324/haematol.2020.268037.
    10.3324/haematol.2020.268037
  8. Apollonio, Benedetta; Ioannou, Nikolaos; Papazoglou, Despoina; Ramsay, Alan G.. "Understanding the Immune-Stroma Microenvironment in B Cell Malignancies for Effective Immunotherapy". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.626818.
    10.3389/fonc.2021.626818
  9. Patten, Piers E. M.; Ferrer, Gerardo; Chen, Shih-Shih; Kolitz, Jonathan E.; Rai, Kanti R.; Allen, Steven L.; Barrientos, Jacqueline C.; et al. "A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.627020.
    10.3389/fimmu.2021.627020
  10. Ioannou, N.; Hagner, P.R.; Stokes, M.; Gandhi, A.K.; Apollonio, B.; Fanous, M.; Papazoglou, D.; et al. "Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy". Blood 137 2 (2021): 216-231. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099909729&partnerID=MN8TOARS.
    10.1182/blood.2020006073
  11. Vardi, Anna; Vlachonikola, Elisavet; Papazoglou, Despoina; Psomopoulos, Fotis; Kotta, Kostantia; Ioannou, Nikolaos; Galigalidou, Chrysi; et al. "T-Cell Dynamics in Chronic Lymphocytic Leukemia under Different Treatment Modalities". Clinical Cancer Research 26 18 (2020): 4958-4969. http://dx.doi.org/10.1158/1078-0432.ccr-19-3827.
    10.1158/1078-0432.ccr-19-3827
  12. Chiu H; Trisal P; Bjorklund C; Carrancio S; Toraño EG; Guarinos C; Papazoglou D; et al. "Combination lenalidomide-rituximab immunotherapy activates anti-tumour immunity and induces tumour cell death by complementary mechanisms of action in follicular lymphoma.". British journal of haematology (2019): http://europepmc.org/abstract/med/30767211.
    10.1111/bjh.15797
  13. Nikolaos Ioannou; Alan G. Ramsay. "Combination targeted therapy in chronic lymphocytic leukaemia - can pre-clinical studies translate to the clinic?". British Journal of Haematology 182 3 (2018): 315-316. https://doi.org/10.1111/bjh.15279.
    10.1111/bjh.15279
  14. Shok Ping Lim; Nikolaos Ioannou; Alan G. Ramsay; David Darling; Joop Gäken; Ghulam J. Mufti. "miR-181c-BRK1 axis plays a key role in actin cytoskeleton-dependent T cell function". Journal of Leukocyte Biology 103 5 (2018): 855-866. https://kclpure.kcl.ac.uk/portal/en/publications/mir181cbrk1-axis-plays-a-key-role-in-actin-cytoskeletondependent-t-cell-function(f6630c32-785a-4da7-b657-e447910d188c).html.
    10.1002/JLB.1A0817-325RR
  15. Patrick R. Hagner; Hsiling Chiu; Maria Ortiz; Benedetta Apollonio; Maria Wang; Suzana Couto; Michelle F. Waldman; et al. "Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell-mediated cytotoxicity". British Journal of Haematology 179 3 (2017): 399-409. https://kclpure.kcl.ac.uk/portal/en/publications/activity-of-lenalidomide-in-mantle-cell-lymphoma-can-be-explained-by-nk-cellmediated-cytotoxicity(220f3987-b038-4cce-a5b3-d25189aab300).html.
    10.1111/bjh.14866
  16. Dawn T. Smallwood; Benedetta Apollonio; Shaun Willimott; Larissa Lezina; Afaf Alharthi; Ashley R. Ambrose; Giulia De Rossi; Alan G. Ramsay; Simon D. Wagner. "Extracellular vesicles released by CD40/IL-4–stimulated CLL cells confer altered functional properties to CD4+ T cells". Blood 128 4 (2016): 542-552. https://kclpure.kcl.ac.uk/portal/en/publications/extracellular-vesicles-released-by-cd40il4stimulated-cll-cells-confer-altered-functional-properties-to-cd4-t-cells(8d9a40cc-9420-45ea-8422-7b750f69a467).html.
    10.1182/blood-2015-11-682377
  17. Marta Pasikowska; Elisabeth Walsby; Benedetta Apollonio; Kirsty May Cuthill; Elizabeth Helen Phillips; Eve Marie Coulter; Maria Serena Longhi; et al. "Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration.". Blood 128 4 (2016): 563-573. https://kclpure.kcl.ac.uk/portal/en/publications/phenotype-and-immune-function-of-lymph-node-and-peripheral-blood-cll-cells-are-linked-to-transendothelial-migration(83d1fc26-2e14-42dd-86b0-b03e4533ea02).html.
    10.1182/blood-2016-01-683128
  18. Nicole S. Nicholas; Benedetta Apollonio; Alan G. Ramsay. "Tumor microenvironment (TME)-driven immune suppression in B cell malignancy". Biochimica Et Biophysica Acta-Molecular Cell Research 1863 3 (2016): 471-482. https://kclpure.kcl.ac.uk/portal/en/publications/tumor-microenvironment-tmedriven-immune-suppression-in-b-cell-malignancy(aeb25843-8640-40c8-9c56-95c51948bf19).html.
    10.1016/j.bbamcr.2015.11.003
  19. F Boissard; C Laurent; Alan G. Ramsay; A Quillet-mary; J-j Fournié; M Poupot; L Ysebaert. "Nurse-like cells impact on disease progression in chronic lymphocytic leukemia". Blood Cancer Journal 6 1 (2016): e381-e381. https://kclpure.kcl.ac.uk/portal/en/publications/nurselike-cells-impact-on-disease-progression-in-chronic-lymphocytic-leukemia(8a29cec9-0354-45f7-8930-df8d87efb45b).html.
    10.1038/bcj.2015.108
  20. Rinako Nakagawa; Milica Vukovic; Anuradha Tarafdar; Emilio Cosimo; Karen Dunn; Alison M. McCaig; Ailsa Holroyd; et al. "Generation of a poor prognostic chronic lymphocytic leukemia-like disease model". Haematologica 100 4 (2015): 499-510. https://kclpure.kcl.ac.uk/portal/en/publications/generation-of-a-poor-prognostic-chronic-lymphocytic-leukemialike-disease-model(d9e618bc-52e8-4382-82fa-dba0bca93029).html.
    10.3324/haematol.2014.112276
  21. Arnon P. Kater; Sanne H. Tonino; Alexander Egle; Alan G. Ramsay. "How does lenalidomide target the chronic lymphocytic leukemia microenvironment?". Blood 124 14 (2014): 2184-2189. https://kclpure.kcl.ac.uk/portal/en/publications/how-does-lenalidomide-target-the-chronic-lymphocytic-leukemia-microenvironment(cacb2899-f39b-40be-a4ca-07fb9403ed90).html.
    10.1182/blood-2014-05-578286
  22. J. C. Riches; C. J. O'donovan; S. J. Kingdon; F. Mcclanahan; A. J. Clear; D. S. Neuberg; L. Werner; et al. "Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations". Blood 123 26 (2014): 4101-4110. https://kclpure.kcl.ac.uk/portal/en/publications/trisomy-12-chronic-lymphocytic-leukemia-cells-exhibit-upregulation-of-integrin-signaling-that-is-modulated-by-notch1-mutations(f463f6c0-53d4-46bd-a8e0-ad29e84285ac).html.
    10.1182/blood-2014-01-552307
  23. Alan G. Ramsay. "Identifying CLL antigens for future combinational therapy". Blood 122 19 (2013): 3241-3242. https://kclpure.kcl.ac.uk/portal/en/publications/identifying-cll-antigens-for-future-combinational-therapy(f6e231ea-f361-4c88-b4a4-72eaa48acced).html.
    10.1182/blood-2013-09-526376
  24. Abasi Ene-Obong; Andrew J. Clear; Jennifer Watt; Jun Wang; Rewas Fatah; John C. Riches; John F. Marshall; et al. "Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma". Gastroenterology 145 5 (2013): 1121-1132. https://kclpure.kcl.ac.uk/portal/en/publications/activated-pancreatic-stellate-cells-sequester-cd8-t-cells-to-reduce-their-infiltration-of-the-juxtatumoral-compartment-of-pancreatic-ductal-adenocarcinoma(4e75ba78-2ea4-4ef1-ab49-d784aa8035b2).html.
    10.1053/j.gastro.2013.07.025
  25. Alan G. Ramsay. "Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity". British Journal of Haematology 162 3 (2013): 313-325. https://kclpure.kcl.ac.uk/portal/en/publications/immune-checkpoint-blockade-immunotherapy-to-activate-antitumour-tcell-immunity(49855431-c102-498a-bb99-3892c14bcfb5).html.
    10.1111/bjh.12380
  26. S. Kiaii; A. J. Clear; Alan G. Ramsay; D. Davies; A. Sangaralingam; A. Lee; M. Calaminici; D. S. Neuberg; J. G. Gribben. "Follicular lymphoma cells induce changes in T-cell gene expression and function". Journal of clinical oncology : official journal of the American Society of Clinical Oncology 31 21 (2013): 2654-2661. https://kclpure.kcl.ac.uk/portal/en/publications/follicular-lymphoma-cells-induce-changes-in-tcell-gene-expression-and-function(4c4d7696-abc4-4f6f-9035-4d04e2c31530).html.
    10.1200/JCO.2012.44.2137
  27. T. D. Shanafelt; Alan G. Ramsay; C. S. Zent; J. F. Leis; H. W. Tun; T. G. Call; B. LaPlant; et al. "Long-term repair of T-cell synapse activity in a phase II trial of chemoimmunotherapy followed by lenalidomide consolidation in previously untreated chronic lymphocytic leukemia (CLL)". Blood 121 20 (2013): 4137-4141. https://kclpure.kcl.ac.uk/portal/en/publications/longterm-repair-of-tcell-synapse-activity-in-a-phase-ii-trial-of-chemoimmunotherapy-followed-by-lenalidomide-consolidation-in-previously-untreated-chronic-lymphocytic-leukemia-cll(e345d1cc-e6bc-48c4-a3ff-05.
    10.1182/blood-2012-12-470005
  28. Alan G. Ramsay; Rachel Evans; S. Kiaii; L. Svensson; N. Hogg; J. G. Gribben. "Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide". Blood 121 14 (2013): 2704-2714. https://kclpure.kcl.ac.uk/portal/en/publications/chronic-lymphocytic-leukemia-cells-induce-defective-lfa1directed-tcell-motility-by-altering-rho-gtpase-signaling-that-is-reversible-with-lenalidomide(5f53bcf9-217c-40b1-9325-4e489fe27f94).html.
    10.1182/blood-2012-08-448332
  29. J. C. Riches; J. K. Davies; F. McClanahan; R. Fatah; S. Iqbal; S. Agrawal; Alan G. Ramsay; J. G. Gribben. "T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production". Blood 121 9 (2013): 1612-1621. https://kclpure.kcl.ac.uk/portal/en/publications/t-cells-from-cll-patients-exhibit-features-of-tcell-exhaustion-but-retain-capacity-for-cytokine-production(dc6e13b9-cfa7-4bbb-88ea-433858d4373a).html.
    10.1182/blood-2012-09-457531
  30. Alan G. Ramsay; Andrew J. Clear; Rewas Fatah; John G. Gribben. "Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide". Blood 120 7 (2012): 1412-1421. https://kclpure.kcl.ac.uk/portal/en/publications/multiple-inhibitory-ligands-induce-impaired-tcell-immunologic-synapse-function-in-chronic-lymphocytic-leukemia-that-can-be-blocked-with-lenalidomide(35be2fa1-6891-49e4-ae02-41cd32b71c33).html.
    10.1182/blood-2012-02-411678
  31. J. C. Riches; Alan G. Ramsay; J. G. Gribben. "Immune dysfunction in chronic lymphocytic leukemia". CURRENT PHARMACEUTICAL DESIGN 18 23 (2012): 3389-3398. https://kclpure.kcl.ac.uk/portal/en/publications/immune-dysfunction-in-chronic-lymphocytic-leukemia(ef0796f8-cbcd-40d2-a614-9d1263395f67).html.
    10.2174/138161212801227023
  32. John C. Riches; Alan G. Ramsay; John G. Gribben. "Immune reconstitution in chronic lymphocytic leukemia". Current hematologic malignancy reports 7 1 (2012): 13-20. https://kclpure.kcl.ac.uk/portal/en/publications/immune-reconstitution-in-chronic-lymphocytic-leukemia(2bf3422e-739f-459a-833d-b547ed5dab83).html.
    10.1007/s11899-011-0106-x
  33. Alan G. Ramsay; John G. Gribben. "The kiss of death in FL". Blood 118 20 (2011): 5365-5366. https://kclpure.kcl.ac.uk/portal/en/publications/the-kiss-of-death-in-fl(7e37b6c2-14c5-44bd-b7d4-a0e7fb2c54ac).html.
    10.1182/blood-2011-09-377283
  34. John C. Riches; Alan G. Ramsay; John G. Gribben. "Chronic lymphocytic leukemia". Current Oncology Reports 13 5 (2011): 379-385. https://kclpure.kcl.ac.uk/portal/en/publications/chronic-lymphocytic-leukemia(ce38a958-c25e-4ecd-8b1e-38f8b29a05e0).html.
    10.1007/s11912-011-0188-6
  35. M. R. Morgan; M. Jazayeri; Alan G. Ramsay; G. J. Thomas; M. J. Boulanger; I. R. Hart; J. F. Marshall. "Psoriasin (S100A7) associates with integrin beta6 subunit and is required for alphavbeta6-dependent carcinoma cell invasion". Oncogene 30 12 (2011): 1422-1435. https://kclpure.kcl.ac.uk/portal/en/publications/psoriasin-s100a7-associates-with-integrin-beta6-subunit-and-is-required-for-alphavbeta6dependent-carcinoma-cell-invasion(3496889b-cbe7-48c7-a231-a68a41189485).html.
    10.1038/onc.2010.535
  36. Karen P. Scott; Jenny C. Martin; Christophe Chassard; Marlene Clerget; Joanna Potrykus; Gill Campbell; Claus-Dieter Mayer; et al. "Substrate-driven gene expression in Roseburia inulinivorans". Proceedings of the National Academy of Sciences of the United States of America 108 Supplement (2011): 4672-4679. https://kclpure.kcl.ac.uk/portal/en/publications/substratedriven-gene-expression-in-roseburia-inulinivorans(5beb0f51-2cc2-43d7-ab67-0b59c7190218).html.
    10.1073/pnas.1000091107
  37. John C. Riches; Alan G. Ramsay; John G. Gribben. "T-cell function in chronic lymphocytic leukaemia". Seminars in Cancer Biology 20 6 (2010): 431-438. https://kclpure.kcl.ac.uk/portal/en/publications/tcell-function-in-chronic-lymphocytic-leukaemia(c76de1f5-7ff9-4aed-a08b-ac6562bec987).html.
    10.1016/j.semcancer.2010.09.006
  38. Dongxia Xing; Alan G. Ramsay; John G. Gribben; William K. Decker; Jared K. Burks; Mark Munsell; Sufang Li; et al. "Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with IL-2 exvivo expansion". JOURNAL OF IMMUNOTHERAPY 33 7 (2010): 684-696. https://kclpure.kcl.ac.uk/portal/en/publications/cord-blood-natural-killer-cells-exhibit-impaired-lytic-immunological-synapse-formation-that-is-reversed-with-il2-exvivo-expansion(0544918b-e3ce-41ba-97ef-086d2f5beca3).html.
    10.1097/CJI.0b013e3181e475e9
  39. A. J. Clear; A. M. Lee; M. Calaminici; Alan G. Ramsay; K. J. Morris; S. Hallam; G. Kelly; et al. "Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment". Blood 115 24 (2010): 5053-5056. https://kclpure.kcl.ac.uk/portal/en/publications/increased-angiogenic-sprouting-in-poor-prognosis-fl-is-associated-with-elevated-numbers-of-cd163-macrophages-within-the-immediate-sprouting-microenvironment(e4df6e85-1a7c-40bf-93d3-b61c42f5ad8b).html.
    10.1182/blood-2009-11-253260
  40. Alan G. Ramsay; John G. Gribben. "The 3 Rs in CLL immune dysfunction". Blood 115 13 (2010): 2563-2564. https://kclpure.kcl.ac.uk/portal/en/publications/the-3-rs-in-cll-immune-dysfunction(742af542-0a14-4bd9-a641-4f373a8af2a2).html.
    10.1182/blood-2009-12-256909
  41. Parker, A.; Bowles, K.; Bradley, J.A.; Emery, V.; Featherstone, C.; Gupte, G.; Marcus, R.; et al. "Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines". British Journal of Haematology 149 5 (2010): 675-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952718329&partnerID=MN8TOARS.
    10.1111/j.1365-2141.2010.08161.x
  42. Alan G. Ramsay; A. J. Clear; G. Kelly; R. Fatah; J. Matthews; F. Macdougall; T. A. Lister; et al. "Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide". Blood 114 21 (2009): 4713-4720. https://kclpure.kcl.ac.uk/portal/en/publications/follicular-lymphoma-cells-induce-tcell-immunologic-synapse-dysfunction-that-can-be-repaired-with-lenalidomide(a4d0640b-7cda-4e22-bfe9-40d0325af678).html.
    10.1182/blood-2009-04-217687
  43. R. Le Dieu; D. C. Taussig; Alan G. Ramsay; R. Mitter; F. Miraki-Moud; R. Fatah; A. M. Lee; T. A. Lister; J. G. Gribben. "Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts". Blood 114 18 (2009): 3909-3916. https://kclpure.kcl.ac.uk/portal/en/publications/peripheral-blood-t-cells-in-acute-myeloid-leukemia-aml-patients-at-diagnosis-have-abnormal-phenotype-and-genotype-and-form-defective-immune-synapses-with-aml-blasts(2506af1b-a4d5-4219-960b-0b4b546024ce).htm.
    10.1182/blood-2009-02-206946
  44. Alan G. Ramsay; John G. Gribben. "Immune dysfunction in chronic lymphocytic leukemia T cells and lenalidomide as an immunomodulatory drug". Haematologica 94 9 (2009): 1198-1202. https://kclpure.kcl.ac.uk/portal/en/publications/immune-dysfunction-in-chronic-lymphocytic-leukemia-t-cells-and-lenalidomide-as-an-immunomodulatory-drug(7487a028-57ec-43a2-bd3b-fb9d08d7def5).html.
    10.3324/haematol.2009.009274
  45. G. Gorgun; Alan G. Ramsay; T. A. Holderried; D. Zahrieh; R. Le Dieu; F. Liu; J. Quackenbush; C. M. Croce; J. G. Gribben. "E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction". Proceedings of the National Academy of Sciences of the United States of America 106 15 (2009): 6250-6255. https://kclpure.kcl.ac.uk/portal/en/publications/emutcl1-mice-represent-a-model-for-immunotherapeutic-reversal-of-chronic-lymphocytic-leukemiainduced-tcell-dysfunction(f2a52e7c-855c-4d1b-860e-fabb9ad6257e).html.
    10.1073/pnas.0901166106
  46. Alan G. Ramsay; J. G. Gribben. "Vaccine therapy and chronic lymphocytic leukaemia". Baillieres Best Practice & Research in Clinical Haematology 21 3 (2008): 421-436. https://kclpure.kcl.ac.uk/portal/en/publications/vaccine-therapy-and-chronic-lymphocytic-leukaemia(997af621-54b8-4ca5-ba33-fd9c728dc673).html.
    10.1016/j.beha.2008.07.005
  47. Alan G. Ramsay; A. J. Johnson; A. M. Lee; G. Gorgun; R. Le Dieu; W. Blum; J. C. Byrd; J. G. Gribben. "Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug". Journal of Clinical Investigation 118 7 (2008): 2427-2437. https://kclpure.kcl.ac.uk/portal/en/publications/chronic-lymphocytic-leukemia-t-cells-show-impaired-immunological-synapse-formation-that-can-be-reversed-with-an-immunomodulating-drug(0a3bbdd1-75dd-4949-894f-23723d89bbc0).html.
    10.1172/JCI35017
  48. Alan G. Ramsay; J. F. Marshall; I. R. Hart. "Integrin trafficking and its role in cancer metastasis". Cancer and Metastasis Reviews 26 3-4 (2007): 567-578. https://kclpure.kcl.ac.uk/portal/en/publications/integrin-trafficking-and-its-role-in-cancer-metastasis(9a682622-2a94-42d5-afb4-b57c6382eeaa).html.
    10.1007/s10555-007-9078-7
  49. Alan G. Ramsay; Melanie D. Keppler; Mona Jazayeri; Gareth J. Thomas; Maddy Parsons; Shelia Violette; Paul Weinreb; Ian R. Hart; John F. Marshall. "HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin avß6". Cancer Research 67 11 (2007): 5275-5284. https://kclpure.kcl.ac.uk/portal/en/publications/hs1associated-protein-x1-regulates-carcinoma-cell-migration-and-invasion-via-clathrinmediated-endocytosis-of-integrin-v6(82f30a23-3f79-4fcb-bddf-f6c622481ef5).html.
    10.1158/0008-5472.CAN-07-0318
  50. Alan G. Ramsay; K. P. Scott; J. C. Martin; M. T. Rincon; H. J. Flint. "Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon". Microbiology 152 11 (2006): 3281-3290. https://kclpure.kcl.ac.uk/portal/en/publications/cellassociated-alphaamylases-of-butyrateproducing-firmicute-bacteria-from-the-human-colon(2cb6cbd8-72e1-4656-aedc-8630611fa27f).html.
    10.1099/mic.0.29233-0
  51. S. H. Duncan; K. P. Scott; Alan G. Ramsay; H. J. Harmsen; G. W. Welling; C. S. Stewart; H. J. Flint. "Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system". Applied and Environmental Microbiology 69 2 (2003): 1136-1142. https://kclpure.kcl.ac.uk/portal/en/publications/effects-of-alternative-dietary-substrates-on-competition-between-human-colonic-bacteria-in-an-anaerobic-fermentor-system(9f3b3372-1ef2-4035-9005-a61f3945d86c).html.
    10.1128/AEM.69.2.1136-1142.2003

Outros

Outra produção
  1. Subclonal heterogeneity in chronic lymphocytic leukaemia. Revealing the importance of the lymphoid tumour microenvironment. 2016. Benedetta Apollonio; Alan G. Ramsay. https://kclpure.kcl.ac.uk/portal/en/publications/subclonal-heterogeneity-in-chronic-lymphocytic-leukaemia(e2ffa6a7-9a02-478d-b74e-1982781c700b).html.
    10.1111/bjh.13856
  2. Exosomes and CAFs. Partners in crime. 2015. Benedetta Apollonio; Alan G. Ramsay. https://kclpure.kcl.ac.uk/portal/en/publications/exosomes-and-cafs(4e2e1b78-7060-4c44-9faf-f3963df6fee6).html.
    10.1182/blood-2015-07-655233
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021 Invited faculty and speaker at the prestigious 19th international workshops on CLL (wCLL 2021) - "Modelling the tumor microenvironment" 19th international workshops on CLL (wCLL 2021)
2021 Invited speaker at the annual British Society of Immunology BSI meeting 2019, Cambridge Lymphoma Biology International Symposium 2021 the annual British Society of Immunology BSI meeting 2019
2021 Faculty, invited speaker, 16th International CLL/cancer workshops, Salzburg 2021 16th International CLL/cancer workshops
2019 Invited faculty and speaker at the prestigious 18th international workshops on CLL (iwCLL 2019) - Modelling the tumor microenvironment. 18th international workshops on CLL (iwCLL 2019)
2018 Diffuse Large B-Cell Lymphoma Remodels the Fibroblastic Reticular Network That Acquires Aberrant Immunosuppressive Capabilities; Implications for the Regulation of Anti-Tumor Immunity in the Immuno-Oncology Era 60th annual meeting of the ASH
American Society of Hematology (ASH)
2018 Ibrutinib-Based Therapy Improves Anti-Tumor T Cell Killing Function Allowing Effective Pairing with Anti-PD-L1 Immunotherapy Compared to Traditional FCR Chemoimmunotherapy; Implications for Therapy and Correlative Immune Functional Data from the Phase III E1912 Trial. 60th annual meeting of the ASH
American Society of Hematology (ASH)
2018 Eliciting Anti-Tumor T Cell Immunity in Chronic Lymphocytic Leukemia (CLL) with PD-L1/PD-1 Blockade Is Enhanced By Avadomide Immunotherapy through the Triggering of Immunogenic Interferon Signaling. 60th annual meeting of the ASH
American Society of Hematology (ASH)
2018 Faculty, invited speaker, 14th International CLL/cancer workshops, Salzburg 2018 14th International CLL/cancer workshops
2017/05 Faculty, invited speaker, 2nd Nordic Meeting on Tumor Microenvironment in Lymphoma. Aarhus, May, 2017. Presentation: "Lymphoma-induced stromal reprogramming contributes to immunosuppression in the microenvironment; implications for optimizing combination immunotherapy". 2nd Nordic Meeting on Tumor Microenvironment in Lymphoma
2nd Nordic Meeting on Tumor Microenvironment in Lymphoma (Aarhus, Dinamarca)
2016/09 Invited speaker, Xth International workshop, German CLL study Group, Cologne, 2016. Presentation: "Targeting TME to optimize checkpoint inhibition" Xth International workshop German CLL study Group
German CLL study Group (Cologne, Alemanha)
2016 Invited speaker, 3rd Immunotherapy of Cancer Conference (ITOC), Munich 2016 3rd Immunotherapy of Cancer Conference (ITOC)
(Munich, Alemanha)
2015/12 American Society of Hematology ASH, 57th Annual Meeting, Orlando, Florida, December 2015, Program: Scientific program: "Targeting the Tumor Microenvironment in Lymphoid Malignancies." https://ash.confex.com/ash/2015/webprogram/Session6166.html American Society of Hematology ASH, 57th Annual Meeting
2015 Invited speaker, 2nd Immunotherapy of Cancer Conference (ITOC), Munich 2015 2nd Immunotherapy of Cancer Conference (ITOC)
(Munich, Alemanha)
2015 Invited speaker, UK CLL forum, British Society for Hematology (BSH) annual scientific meeting, Edinburgh 2015 UK CLL forum, British Society for Hematology (BSH) annual scientific meeting
British Society for Hematology (BSH) (Edinburgh)
2014 Invited lecture, European Hematology Association (EHA) congress 2014, Milano, Scientific Working Group (Harnessing the immune system to treat chronic lymphocytic leukemia). European Hematology Association (EHA) congress 2014
(Milano)
2014 Invited lecture, Leukaemia & Lymphoma Research (LLR) symposium, British Society for Hematology BSH annual scientific meeting 2014, Birmingham (How lymphoma subverts the immune system) Leukaemia & Lymphoma Research (LLR) symposium
British Society for Hematology BSH (Birmingham)
2012 Presidential symposium, 17th Congress of the European Hematology Association (EHA), June 2012, Amsterdam.
2012 Presidential symposium, 17th Congress of the European Hematology Association (EHA), June 2012, Amsterdam.

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022 - Atual Studying the impact of therapy on T cells in chronic lymphocytic leukemia
Orientador
 PhD (Doutoramento)
2018/10/01 - 2022/12/30 Investigation of the validity of combination targeting of PAK family kinases in ovarian cancer
Coorientador
 PhD (Doutoramento)
2018/10/01 - 2022/10/01 Translational studies on the role of adipocytes in the tumor microenvironment in B cell lymphoma
Coorientador
2017/10/01 - 2021/12/01 Investigating combination immunotherapy in chronic lymphocytic leukaemia
Orientador
2016/10/01 - 2020/12/30 Investigating how diffuse large B-cell lymphoma alters stromal cells in the tumour microenvironment
Orientador
2016/01/04 - 2020/01/03 Investigating the role of diffuse large B-cell lymphoma exosomes in the tumour microenvironment
Orientador
2019/09/01 - 2019/09/30 Investigating how chronic lymphocytic leukaemia modulates the fibroblastic reticular network and its contribution to immunosuppression in the tumour microenvironment
Orientador
2015/04/27 - 2019/03/26 Investigating the effect of diffuse large B-cell lymphoma on endothelial cell phenotype and immunomodulatory functions
Orientador

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2012 - Atual • Presidential symposium, 17th Congress, EHA, June 2012, Amsterdam.
Simpósio
 17th Congress

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2015 - 2017 American Society of Hematology, ASH Scientific Committee member: Lymphoid Neoplasia (2015-2017).

Tutoria

Tópico Nome do aluno
2014 - Atual Postgraduate Coordinator, School of Cancer Sciences, King’s College London. Postgraduate Coordinator
2013 - Atual Undergraduate Immunology (BSc, medical) and Postgraduate Teaching (lectures, tutorials, MRes project supervision), King’s College London. Undergraduate Immunology (BSc, medical) and Postgraduate Teaching
2015 - 2015 Module Co-Leader (2nd year Immunology) "Immune system in health and disease." KCL. 2nd year Immunology
2011 - 2013 Teaching Lead for the Centre for Haemato-Oncology, Barts Cancer Institute, QMUL Teaching Lead for the Centre for Haemato-Oncology
2006 - 2013 Module Leader for MSc module: “Molecular targeted Therapies and Immunotherapy for Blood cancer”. Curriculum & examination design, lecturing & assessment. Undergraduate (BSc, medical) and Postgraduate teaching, Barts Cancer Institute, QMUL Module Leader for MSc module
Distinções

Prémio

2021 Cover images for Blood journal: Ioannou., et al 2021
2016 Cover images for Blood journal: Smallwood et al 2016
2013 Nature Reviews Clinical Oncology research highlight on Shanafelt & Ramsay Blood 2013 demonstrating the utility of the T-cell synapse bioassay during a phase II cancer patient clinical trial. (http://www.ncbi.nlm.nih.gov/pubmed/23546519)
2012 Top-ranking abstract for the European Hematology Association (EHA) 2012
2012 Cover images for Blood journal: Ramsay et al., 2012
2012 Invited to author a “Hematology in focus” article for the European Hematology Association (EHA) newsletter (November 2012 edition: (http://ehaweb.org/news/publications/eha-newsletter)
2008 Performance Recognition Reward 2008 (Queen Mary University of London).

Outra distinção

2014 British Society for Haematology (BSH) Fellowship
2009 European Hematology Association (EHA) Fellowship grant