Ana Filipa de Albuquerque Ferreira Rodrigues (0F13-46AE-BE31)

Curriculum Vitae

Ana Filipa de Albuquerque Ferreira Rodrigues

Ana Filipa Rodrigues holds a Degree in Biochemistry (2007) from Universidade de Lisboa and a Ph.D. in Biotechnology (2014) from Universidade Nova de Lisboa and the University of Minnesota (UofM). During her early research, Ana applied functional genomics, big data analytics, and genetic engineering to improve the production of viral vectors for human gene therapy. In 2016, she joined the Experimental Virology Department (Hannover Medical School/TWINCORE) as a post-doctoral researcher in Virology to study virus-host interactions for the development of antiviral therapies and vaccines. Since 2018, Ana has been a Senior Scientist at Instituto de Biologia Experimental e Tecnológica working in cell and gene therapy, viral vaccines, and molecular biology and, since 2022, she is also a researcher at LASIGE Computer Science and Engineering Research Centre (University of Lisbon, Portugal). Ana has been actively engaged in international industrial projects, translating her academic research into technological advances and market value. As a leading investigator, Ana secured 360K Euros in funding and was awarded several prizes including the Early Career Research Award in 2020. She has published 21 peer-reviewed articles, 3 book chapters, 2 conference proceedings, and 1 patent, generating more than 700 citations and an h-index of 15. In addition, Ana has presented at renowned conferences in her field, including the meetings of ESACT, ESGCT, and CCE, dozens of posters and oral communications, many of which as an invited speaker. Ana supervised 9 MSc students, is currently co-supervisor of one MSC and two PhD students and one MSc student and teaches in several MSc and PhD programs. Beyond R&D activities, Ana was a founding member and part of the executive committee until 2019 of the Frontiers Program, an initiative of the European Society of Animal Cell Technology (ESACT) to foster the progress of junior researchers. In the scope of this program, she organized two international meetings with more than 100 participants, coordinated workshops and courses, and provided mentoring to dozens of M.Sc. and Ph.D. students. She was also co-chair of the Post-Doctoral Association of ITQB-NOVA & iBET (2018-2019), where she implemented a program to support early career researchers' training and professional development. In 2019 Ana graduated in Information Management and Business Intelligence in Healthcare from Information Management School (IMS-NOVA, Portugal) and, since September 2022, she has been enrolled in the MSc degree in Data Sciences at the Faculty of Sciences (Universidade de Lisboa, Portugal) getting additional training in machine learning and artificial intelligence, which she aims to further explore in her biomedical and bioengineering research.

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Identificação

Identificação pessoal

Nome completo: Ana Filipa de Albuquerque Ferreira Rodrigues

Nomes de citação

Rodrigues, Ana F.

Identificadores de autor

Ciência ID: 0F13-46AE-BE31
ORCID iD: 0000-0002-1705-3243

Endereços de correio eletrónico

anafr@ibet.pt (Profissional)
afdrodrigues@fc.ul.pt (Profissional)

Moradas

Apartado 12, 2781-901, Oeiras, Oeiras, Portugal (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
Ciências Médicas e da Saúde - Biotecnologia Médica - Diagnóstico e Terapias de Base Genética
Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Tecnologias de BioProcessamento
Ciências Naturais - Ciências Biológicas - Biologia Molecular
Ciências Naturais - Ciências Biológicas - Bioquímica
Ciências Naturais - Ciências Biológicas - Virologia
Ciências Exatas - Ciências da Computação e da Informação - Bioinformática
Ciências Exatas - Ciências da Computação e da Informação - Ciências da Informação

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Espanhol; Castelhano	Utilizador elementar (A2)	Utilizador independente (B2)	Utilizador elementar (A2)	Utilizador independente (B2)	Utilizador elementar (A2)
Francês	Utilizador elementar (A1)	Utilizador elementar (A2)	Utilizador elementar (A1)	Utilizador elementar (A2)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2022 - 2024 Em curso	MSc in Data Sciences (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2019 Concluído	Post-Graduation Program, Information Management and Business Intelligence in Healthcare (Pós-Graduação) Especialização em Information management NOVA-IMS (Information Management School) / Universidade Nova de Lisboa - Faculdade de Gestão de Informação, Portugal
2015 - 2018 Concluído	Hepathology and hepatotropic pathogens - focus on HCV (Pós-doutoramento) Especialização em Virology TWINCORE Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Alemanha iBET-Instituto de Biologia Experimental e Tecnológica, Portugal
2009 - 2014 Concluído	PhD in Engineering and Technology Sciences (Doutoramento) Especialização em Biotechnology Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal University of Minnesota Department of Chemical Engineering and Materials Science, Estados Unidos	Best PhD Thesis Award
2002 - 2007 Concluído	Biochemistry (Licenciatura) Especialização em Biochemistry Universidade de Lisboa Faculdade de Ciências, Portugal	Top 10%

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2022 - Atual	Investigador (Investigação)	Universidade de Lisboa Faculdade de Ciências, Portugal
	Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - Atual	Investigador Contratado (Investigação)	iBET-Instituto de Biologia Experimental e Tecnológica, Portugal
	iBET-Instituto de Biologia Experimental e Tecnológica, Portugal
2016 - 2018	Pós-doutorado (Investigação)	iBET-Instituto de Biologia Experimental e Tecnológica, Portugal
	iBET-Instituto de Biologia Experimental e Tecnológica, Portugal
2016 - 2016	Investigador visitante (Investigação)	TWINCORE Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Alemanha

2014 - 2015	Pós-doutorado (Investigação)	iBET-Instituto de Biologia Experimental e Tecnológica, Portugal

2010 - 2011	Investigador visitante (Investigação)	University of Minnesota Department of Chemical Engineering and Materials Science, Estados Unidos

2007 - 2009	Assistente de Investigação (carreira) (Investigação)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Projetos

Bolsa

	Designação	Financiadores
2020 - 2023	LVOLUTION - Bioprocess resistant lentiviral vectors created by directed evolution iBETxplore-718 Investigador responsável	iBET-Instituto de Biologia Experimental e Tecnológica Em curso
2021/01 - 2022/12	LENTISLOOP: Synthetic 5' UTR mRNA-stabilizing-elements to optimize lentiviral vector production for human gene therapy ECRA2020 Investigador responsável	Camara Municipal Oeiras Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica Concluído
2018 - 2022	LIVES - Live cell sensors for virus detection: enabling drug and vaccine development for neglected diseases PTDC/BTM-SAL/30577/2017 Investigador	Fundação para a Ciência e a Tecnologia Concluído
2018/01 - 2020/12	Transcriptome analysis of primary human hepatocytes: disclosing hepatic de-differentiation and liver regeneration pathways iNOVA4Health201707-05-042 Investigador responsável	iNOVA4Health Concluído
2018 - 2019	DELIVER: Debottlenecking lentiviral vector manufacture N/A Investigador	iBET-Instituto de Biologia Experimental e Tecnológica Em curso
2014 - 2016	BRAINVECTORS - From Brain Gene Transfer Towards Gene Therapy: Pharmacological Assessment of AAV, CAV and LVV FP7-PEOPLE-2011-IAPP Investigador	European Commission Seventh Framework Programme for Research and Technological Development Concluído
2013 - 2014	Development of improved suspension MDCK cell lines for the production of virus-based bioproducts: manufacturing Influenza and Adenovirus PTDC/EBB-EBI/118621/2010 Bolseiro de Investigação	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2014	CHIMERA - A novel generation of packaging cell lines for the manufacture of lentivirus based biopharmaceuticals PTDC/EBB-BIO/118615/2010 Bolseiro de Doutoramento	Fundação para a Ciência e a Tecnologia Concluído
2010 - 2013	VIROCELLOME - Using functional genomics to improve mammalian cells for virus based biopharmaceuticals manufacture PTDC/EBB-BIO/100491/2008 Bolseiro de Doutoramento	Fundação para a Ciência e a Tecnologia Concluído
2007 - 2009	CLINIGENE - European Network for the Advancement of Clinical Gene Transfer and Therapy LSHB - CT-2006 -018933 Bolseiro de Investigação	European Commission Sixth Framework Programme Concluído
2007 - 2009	Development of flexible cell lines for the Production of Retrovirus and Lentivirus for Gene Therapy PTDC/BIO/69452/2006 Bolseiro de Investigação	Fundação para a Ciência e a Tecnologia Concluído
2006 - 2008	Production, purification and storage of retroviral vectors produced by modular master producer cells: focus on ColVII vectors for the Epidermolysis Bullosa therapy POCI/V.5/A00003/2005 Bolseiro de Investigação	Fundação para a Ciência e a Tecnologia Concluído

Projeto

	Designação	Financiadores
2020 - 2022	Screening for new cell surface binding targets for severe acute respiratory syndrome coronavirus 2 NA Investigador responsável iBET-Instituto de Biologia Experimental e Tecnológica, Portugal Dualsystems Biotech AG, Suiça	Concluído
2017 - 2018	Implementation of a manufacturing process and QC analytics for GMP production of lentiviral vectors for ex-vivo gene therapy N/A Investigador	Rubius Therapeutics Concluído
2015 - 2017	Stable cell lines for production of retroviral vectors encoding antibody-coupled T cell receptor (ACTR) N/A Investigador	Unum Therapeutics Concluído
2013 - 2013	Retro-VLPs as display platforms of GPCR proteins N/A Bolseiro de Doutoramento	Merck Serono Concluído

Produções

Publicações

Artigo em conferência	Rodrigues, Ana F; Guerreiro, Miguel R; Castro, Rute; Tomas, Helio A; Dalba, Charlotte; Klatzmann, David; Alves, Paula M; Carrondo, Manuel J T; Coroadinha, Ana S. "Down-regulation of CD81 in human cells producing HCV-E1/E2 retroVLPs.". Trabalho apresentado em 22nd European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, 2011. 10.1186/1753-6561-5-S8-P72 Rodrigues, Ana F.; Amaral, A. I.; Carmo, M; Alves, PM; Coroadinha, AS. "The Role of Culture Medium Lipids and Lipid Metabolism in Retroviral Vector Production Under Serum Deprivation". Trabalho apresentado em 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, 2009. Publicado • 10.1007/978-94-007-0884-6_112
Artigo em revista	Vaz, Tiago A.; Rodrigues, Ana F.; Coroadinha, Ana S.. "Exploring nutrient supplementation and bioprocess optimization to improve the production of lentiviral vectors in serum-free medium suspension cultures". Biotechnology Journal 19 1 (2023): http://dx.doi.org/10.1002/biot.202300212. Publicado • 10.1002/biot.202300212 Silva, Gabriela; Rodrigues, Ana F.; Ferreira, Susana; Matos, Carolina; Eleutério, Rute P.; Marques, Gonçalo; Kucheryava, Khrystyna; et al. "Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies toward JAG1-Positive Tumors". Biomolecules 13 3 (2023): 459. http://dx.doi.org/10.3390/biom13030459. Acesso aberto • Publicado • 10.3390/biom13030459 Arez, Francisca; Rodrigues, Ana F.; Brito, Catarina; Alves, Paula M.. "Bioengineered Liver Cell Models of Hepatotropic Infections". Viruses 13 5 (2021): 773. http://dx.doi.org/10.3390/v13050773. Publicado • 10.3390/v13050773 Rodrigues, Ana Filipa; Fernandes, Paulo; Laske, Tanja; Castro, Rute; Alves, Paula Marques; Genzel, Yvonne; Coroadinha, Ana Sofia. "Cell Bank Origin of MDCK Parental Cells Shapes Adaptation to Serum-Free Suspension Culture and Canine Adenoviral Vector Production". International Journal of Molecular Sciences 21 17 (2020): 6111. Publicado • 10.3390/ijms21176111 Formas-Oliveira, Ana S.; Basílio, João S.; Rodrigues, Ana F.; Coroadinha, Ana S.. "Overexpression of ER Protein Processing and Apoptosis Regulator Genes in Human Embryonic Kidney 293 Cells Improves Gene Therapy Vectors Production". Biotechnology Journal 15 9 (2020): 1900562. Publicado • 10.1002/biot.201900562 Tomás, Hélio A.; Mestre, Daniel A.; Rodrigues, Ana F.; Guerreiro, Miguel R.; Carrondo, Manuel J.T.; Coroadinha, Ana Sofia. "Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes". Molecular Therapy - Methods & Clinical Development 15 (2019): 1-8. Publicado • 10.1016/j.omtm.2019.08.001 Nina Schmolka; Pedro H. Papotto; Paula Vargas Romero; Tiago Amado; Francisco J. Enguita; Ana Amorim; Ana F. Rodrigues; et al. "MicroRNA-146a controls functional plasticity in ¿d T cells by targeting NOD1". Science Immunology 3 23 (2018): eaao1392-eaao1392. Publicado • 10.1126/sciimmunol.aao1392 Tomas, H. A.; Rodrigues, A. F.; Carrondo, M. J. T.; Coroadinha, A. S.. "LentiPro26: novel stable cell lines for constitutive lentiviral vector production". Scientific Reports 8 (2018): Publicado • 10.1038/s41598-018-23593-y Rodrigues, A. F.; Guerreiro, M. R.; Formas-Oliveira, A. S.; Fernandes, P.; Blechert, A. -K.; Genzel, Y.; Alves, P. M.; Hu, W. S.; Coroadinha, A. S.. "Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK". Biotechnology and Bioengineering 113 1 (2016): 150-162. Publicado • 10.1002/bit.25691 Soares, H. R.; Castro, R.; Tomas, H. A.; Rodrigues, A. F.; Gomes-Alves, P.; Bellier, B.; Klatzmann, D.; et al. "Tetraspanins displayed in retrovirus-derived virus-like particles and their immunogenicity". Vaccine 34 13 (2016): 1634-1641. Publicado • 10.1016/j.vaccine.2015.12.015 Rodrigues, Ana F.; Soares, Hugo R.; Guerreiro, Miguel R.; Alves, Paula M.; Coroadinha, Ana S.. "Viral vaccines and their manufacturing cell substrates: New trends and designs in modern vaccinology". Biotechnology Journal 10 9 (2015): 1329-1344. Publicado • 10.1002/biot.201400387 Rodrigues, A. F.; Formas-Oliveira, A. S.; Guerreiro, M. R.; Tomas, H. A.; Alves, P. M.; Coroadinha, A. S.. "Single-step cloning-screening method: a new tool for developing and studying high-titer viral vector producer cells". Gene Therapy 22 9 (2015): 685-695. Publicado • 10.1038/gt.2015.44 Silva, Marta M; Rodrigues, Ana F; Correia, Claudia; Sousa, Marcos F Q; Brito, Catarina; Coroadinha, Ana S; Serra, Margarida; Alves, Paula M. "Robust Expansion of Human Pluripotent Stem Cells: Integration of Bioprocess Design With Transcriptomic and Metabolomic Characterization.". Stem cells translational medicine 4 7 (2015): 731-42. Publicado • 10.5966/sctm.2014-0270 Rodrigues, Ana F.; Carrondo, Manuel J. T.; Alves, Paula M.; Coroadinha, Ana S.. "Cellular targets for improved manufacturing of virus-based biopharmaceuticals in animal cells". Trends in Biotechnology 32 12 (2014): 602-607. Publicado • 10.1016/j.tibtech.2014.09.010 Fernandes, Paulo; Santiago, Virginia M.; Rodrigues, Ana F.; Tomas, Helio; Kremer, Eric J.; Alves, Paula M.; Coroadinha, Ana S.. "Impact of E1 and Cre on Adenovirus Vector Amplification: Developing MDCK CAV-2-E1 and E1-Cre Transcomplementing Cell Lines". Plos One 8 4 (2013): Publicado • 10.1371/journal.pone.0060342 Rodrigues, A. F.; Formas-Oliveira, A. S.; Bandeira, V. S.; Alves, P. M.; Hu, W. S.; Coroadinha, A. S.. "Metabolic pathways recruited in the production of a recombinant enveloped virus: Mining targets for process and cell engineering". Metabolic Engineering 20 (2013): 131-145. Publicado • 10.1016/j.ymben.2013.10.001 Rodrigues, A. F.; Amaral, A. I.; Verissimo, V.; Alves, P. M.; Coroadinha, A. S.. "Adaptation of retrovirus producer cells to serum deprivation: Implications in lipid biosynthesis and vector production". Biotechnology and Bioengineering 109 5 (2012): 1269-1279. Publicado • 10.1002/bit.24410 Bandeira, Vanessa; Peixoto, Cristina; Rodrigues, Ana F.; Cruz, Pedro E.; Alves, Paula M.; Coroadinha, Ana S.; Carrondo, Manuel J. T.. "Downstream Processing of Lentiviral Vectors: Releasing Bottlenecks". Human Gene Therapy Methods 23 4 (2012): 255-263. Publicado • 10.1089/hgtb.2012.059 Rodrigues, A. F.; Guerreiro, M. R.; Santiago, V. M.; Dalba, C.; Klatzmann, D.; Alves, P. M.; Carrondo, M. J. T.; Coroadinha, A. S.. "Down-Regulation of CD81 Tetraspanin in Human Cells Producing Retroviral-Based Particles: Tailoring Vector Composition". Biotechnology and Bioengineering 108 11 (2011): 2623-2633. Publicado • 10.1002/bit.23231 Carmo, M; Alves, A; Rodrigues, AF; Coroadinha, AS; Carrondo, MJT; Alvesi, PM; Cruz, PE. "Stabilization of gammaretroviral and lentiviral vectors: from production to gene transfer". Journal of Gene Medicine 11 8 (2009): 670-678. Publicado • 10.1002/jgm.1353 Rodrigues, AF; Carmo, M; Alves, PM; Coroadinha, AS. "Retroviral Vector Production Under Serum Deprivation: The Role of Lipids". Biotechnology and Bioengineering 104 6 (2009): 1171-1181. Publicado • 10.1002/bit.22499
Capítulo de livro	Tomas, H. A.; Rodrigues, A. F.; Alves, P. M.; Coroadinha, A. S.. "Lentiviral Gene Therapy Vectors: Challenges and Future Directions". In Gene Therapy - Tools and Potential Applications, editado por Francisco Martin. InTech, 2013. Publicado • 10.5772/52534 Coroadinha, A. S.; Rodrigues, Ana F.; Gama-Norton, L; Duros, C; Cohen-Haguenauer, O; Alves, PM; Cruz, PE; Carrondo, MJT; Hauser, H. "Modular retroviral producer cell lines". In The CliniBook: Clinical gene transfer, editado por Odile Cohen-Haguenauer. 2012. Publicado Rodrigues, AF; Alves, PM; Coroadinha, Ana S. "Production of Retroviral and Lentiviral Gene Therapy Vectors: Challenges in the Manufacturing of Lipid Enveloped Virus". In Viral Gene Therapy, editado por Ke Xu. InTech, 2011. Publicado • 10.5772/18615
Poster em conferência	Rodrigues, Ana F.. "More than 40 posters presented at international conferences in the fields of cell and gene therapy, animal cell technology, virology and vectorology and vaccines.". 2022.
Tese / Dissertação	Rodrigues, Ana F.. "Integrated functional genomics for improved manufacture of recombinant enveloped virus: Transcriptional profiling and metabolic engineering of retrovirus producer cells". Doutoramento, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, 2014. Rodrigues, Ana F.. "Effect of fetal bovine serum on the production of gene therapy retroviral vectors: the role of culture medium lipids". Licenciatura, Universidade de Lisboa Faculdade de Ciências, 2007.

Propriedade Intelectual

Patente

Tomás, HA; Mestre, Daniel A.; Rodrigues, Ana F.; Coroadinha, Ana S.. 2022. "WO2020234810A1 - Modified envelope glycoproteins for retroviridae viral vector pseudotyping and process for obtaining it".
Concedida/Emitida

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2020/12	Vector and cell-engineering approaches for improved production of lentiviral vectors for human gene therapy	ITQB Seminars Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/11	Cell- and vector-engineering for manufacturing gene therapy lentiviral vectors from constitutive producer cell lines	11th PEGS Europe - Protein and Antibody Engineering Summit Cambridge Innovation Institute (Lisbon, Portugal)
2019/10	Cell- and vector-engineering approaches for manufacturing high-titer GaLV pseudotyped lentiviral vectors from stable and constitutive producer cell lines	27th Congress of European Society for Gene and Cell Therapy Annual Congress (ESGCT) European Society for Gene and Cell Therapy (Barcelona, Espanha)
2018/01	Improved manufacturing of retroviral and lentiviral vectors for gene therapy: flexible molecular tools, smart screening methods & functional genomics approaches	28th meeting of ESACT-UK ESACT-UK (Leeds, Reino Unido)
2017/03	Functional genomics and genetic engineering for improved manufacturing of viral vectors for gene therapy	ITQB Seminars Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/09	Impact of the cell source on the production of clinical-grade vectors: cGMP considerations and cell line engineering perspectives	BrainVectors Workshop BrainVectors Consortium (Lausanne, Suiça)
2016/09	Development of HCV vaccine candidates using retroVLPs as manufacturing platform	10th Vaccine Congress Elsevier (Amsterdam, Países Baixos)
2014/05	Multi-gene engineering of mammalian cell metabolism: new approaches and tools in the pursuit of hyperproductivity	14th Cell Culture Engineering Meeting ECI (Quebec, Canadá)
2013/05	Multi-gene engineering of mammalian cell metabolism: walking the steps towards hyperproductivity	23rd meeting of European Society of Animal Cells Technology (ESACT) ESACT (Lille, França)
2009/09	Towards serum free production of retroviral vectors: Lipid supplementation strategies and manipulation of cells lipid metabolism	Clinigene European Network of Excellence for Gene Therapy Meeting Clinigene European Network of Excellence for Gene Therapy (Lucca, Itália)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2021 - Atual	Novel packaging systems with abolished cytotoxicity: development of high-titer lentiviral vector producer cells Coorientador	Ciências da Engenharia e Tecnologia (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020 - Atual	HELV - High titer lentiviral vector producer cell lines based on replicative transposition Coorientador	Ciências da Engenharia e Tecnologia (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021 - 2022	New synthetic biology elements to stabilize mRNA and improve the production of lentiviral vectors for human gene therapy Coorientador	Microbiologia Médica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2020	New hepatic cell lines for research, drug screening and vaccine development: molecular tools for high-throughput screening of HCV replicating cells Orientador	Biotecnologia (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019	New in vitro models and synthetic biology tools for research and drug discovery against hepatotropic pathogens Orientador	Biologia Molecular e Genética (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2019	Pseudotyped lentiviral vectors for gene therapy: Impact of envelope glycoproteins Orientador	Microbiologia Médica (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017/09 - 2018/09	New hepatic cell lines for research, drug screening and vaccine development Orientador	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2018	Overcoming the cytotoxicity of high-titer envelope glycoproteins for the establishment of novel cell lines for stable production of lentiviral vector Orientador	Double Diploma Degree - Chemistry / Process Engineering (Licenciatura/Bacharelato) École Supérieure de Chimie Physique Électronique de Lyon, França
2016 - 2017	Genetic engineering of mammalian cell lines for improved production of gene therapy viral vectors Coorientador	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015 - 2016	A novel generation of lentiviral vectors for gene therapy Coorientador	Biotecnologia (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2018 - 2019	Chair and organizer of the workshop 'Design Thinking to foster creativity and innovation' at the 26th ESACT meeting (Copenhagen, Denmark, May 2019) (2019/05) Oficina (workshop) (Coorganizador)	ESACT - European Society of Animal Cell Technology, Alemanha
2017 - 2018	2nd International ESACT Frontiers Retreat (Zagreb, Croatia) (2018/10) Conferência (Membro da Comissão Organizadora)	ESACT - European Society of Animal Cell Technology, Alemanha
2017 - 2017	Science communication video contest at the 25th ESACT meeting ( Lausanne, Switzerland) (2017/05) Outro (Coorganizador)	ESACT - European Society of Animal Cell Technology, Alemanha
2015 - 2016	1st International ESACT Frontiers Retreat, Lyon, France, (2016/10) Conferência (Membro da Comissão Organizadora)	ESACT - European Society of Animal Cell Technology, Alemanha
2015 - 2015	Science communication video contest at the 24th ESACT meeting (Barcelona, Spain) (2015/05) Outro (Coorganizador)	ESACT - European Society of Animal Cell Technology, Alemanha

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2018/07 - 2018/07	ITQB Summer Science (summer school) Outro	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/11 - 2017/11	Chair of the 'Technologies of Tomorrow Session' at 8th meeting of PhD students of ITQB-NOVA Encontro	Annual PhD Students Meeting Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/01 - 2017/01	Chair of the 'Into the Future Session' at the 27th ESACT-UK meeting Congresso	Annual ESACT-UK Meeting ESACT-UK: The UK Society for Cell Culture Technology, Reino Unido
2016/10 - 2016/10	Chair of the 'Vaccines & Viral Vectors Session' at the 1st International ESACT Frontiers Retreat (Lyon, France, October 2016) Congresso	International ESACT Frontiers Retreat ESACT - European Society of Animal Cell Technology, Alemanha
2015/11 - 2015/11	Chair of the 'Technology Session' at the 6th meeting of PhD students of ITQB-NOVA Encontro	Annual PhD Students Meeting Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2015/05 - 2015/05	Chair of the 'Emerging Technologies Session' at the 24th ESACT meeting (Barcelona, Spain, May 2015) Congresso	Biennial ESACT Meeting ESACT - European Society of Animal Cell Technology, Alemanha

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2022	Data Science Methods Applied to the Study of The Signature of Regulatory CD4 T Cells in the Human Thymus and its Modulation by the Chromatin Landscape Arguente principal	Susana Maria Santos do Paço (Mestrado) Universidade Nova de Lisboa - Faculdade de Gestão de Informação, Portugal
2022	A cell-type specific selection system for stem cell therapy (and other) purposes Vogal	Duarte Pólvora Brandão (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/02/24	New hepatic cell lines for research, drug screening and vaccine development: molecular tools for high-throughput screening of HCV replicating cells Orientador	Maria João Cunha Coelho Rodrigues Carreiro (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021	Development of antibodies against the Notch ligands DLL1 and JAG1 with potential activity against cancer Arguente	Carolina Branquinho de Matos (Outro) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2021	Transcriptional Program Biosensors for Human Cell Type and State Diagnosis Arguente	Benilde Francisco Pondeca (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/12/06	New in vitro models and synthetic biology tools for research and drug discovery against hepatotropic pathogens Orientador	Maria Marques da Silva Mega da Fonseca (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2020/12/05	Pseudotyped lentiviral vectors for gene therapy: impact of envelope glycoproteins Orientador	Rodrigo José Gameiro Nogueira (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2018 - 2018	2nd International ESACT Frontiers Retreat (Zagreb, Croatia)	ESACT - European Society of Animal Cell Technology

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2015 - Atual	Lecturer in the program of Biopharmaceuticals, subject of Biochemistry for Health Master's Degree	Biochemistry for Health (Mestrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014 - 2018	Lecturer at 'Cell line engineering II' course, Module of Animal Cell Technology , PhD Program in Bioengineering Cell Therapies and Regenerative Medicine (CTRM)	PhD Program in Bioengineering Cell Therapies and Regenerative Medicine (Doutoramento)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2017	Assistant lecturer in the program of Biochemistry Engineering II, subject of Biochemical Engineering Master Degree	Biochemical Engineering (Mestrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2009 - Atual	ESACT - The European Society for Animal Cell Technology	Member
2009 - Atual	The European Society for Gene and Cell Therapy (ESGCT)	Member

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2014/10 - 2019/05	Member of the executive committee of ESACT FRONTIERS PROGRAM Membro	ESACT - European Society of Animal Cell Technology, Alemanha
2018/01 - 2018/12	Co-chair of the executive committee of The Post-Doctoral Association of ITQB-NOVA Presidente / Vice-presidente	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/01 - 2017/12	Representative of the post-doctoral researchers for the Division of Technology at ITQB-NOVA Outro	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2014 - Atual	Reviewer in international peer-reviewed journals: Scientific Reports, Biotechnology Journal, Journal of Biotechnology, BMC Biotechnology, Molecular Biotechnology, Applied Microbiology and Biotechnology, Journal of Cellular and Molecular Medicine
2021/02 - 2021/02	Evaluator of Oral Presentation Sessions at the 11th meeting of PhD students of ITQB-NOVA	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/01 - 2020/01	Evaluator of Oral Presentation Sessions at the 10th meeting of PhD students of ITQB-NOVA	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/05 - 2019/05	Evaluator of the Poster Session at the 26th ESACT meeting (Copenhagen, Denmark)	ESACT - European Society of Animal Cell Technology, Alemanha

Distinções

Prémio

2020	Eary Career Research Award Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Camara Municipal Oeiras, Portugal
2015	Best PhD Thesis Award Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014	Student Merit Award Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2009	Poster Presentation Award at the 21st ESACT meeting, Dublin, Ireland ESACT - European Society of Animal Cell Technology, Alemanha

Outra distinção

2020	Honorable Mention for the project 'CAR-T cell immunotherapies against relapsed T-ALL' Rui Osório de Castro Foundation, Portugal Millennium BCP Foundation, Portugal
2015	Post-doctoral Fellowship from FCT Fundação para a Ciência e a Tecnologia, Portugal
2014	Travel Award. Cell Culture Engineering. 14th Cell Culture Engineering Meeting Engineering Conferences International, Estados Unidos
2013	Travel Award. 23rd meeting of ESACT ESACT - European Society of Animal Cell Technology, Alemanha
2009	PhD Fellowship from FCT Fundação para a Ciência e a Tecnologia, Portugal