Juan Alberto Varela (0F1E-9491-BE6A)

Curriculum Vitae

Juan Alberto Varela

Juan Alberto Varela. Completed the Doctor of Philosophy in PhD in Physical Chemistry in 2011/12/06 by University College Dublin and Licence in Licenciatura en Fisica in 2006/02/01 by Universidad de la República Uruguay. Is Principal Investigator in University of St Andrews. Published 19 articles in journals. Has 1 section(s) of books. Participates and/or participated as Principal investigator in 1 project(s). In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Animals; Biological; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Models; N-Methyl-D-Aspartate; N-Methyl-D-Aspartate: metabolism; Neuronal Plasticity; Rats; Receptors; Synapses; Synapses: physiology; bio-nanotechnology; cellular uptake; nanoparticles; single particle tracking; Cell Line; Tumor; Cell Membrane Permeability; Coloring Agents; Coloring Agents: analysis; Coloring Agents: chemistry; Humans; Kinetics; Lysosomes; Lysosomes: metabolism; Lysosomes: ultrastructure; Nanoparticles; Nanoparticles: analysis; Nanoparticles: chemistry; Polymers; Polymers: chemistry; 1321n1 human astrocytoma cells; 7 and 9 activation; amine-modified nanoparticles; apoptosis; caspases 3; .

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Identificação

Identificação pessoal

Nome completo: Juan Alberto Varela

Nomes de citação

Varela, Juan

Identificadores de autor

Ciência ID: 0F1E-9491-BE6A
ORCID iD: 0000-0003-1901-1378

Websites

https://synergy.st-andrews.ac.uk/neurophotonics/ (Profissional)

Formação

	Grau	Classificação
2007/10/01 - 2011/12/06 Concluído	PhD in Physical Chemistry (Doctor of Philosophy) Especialização em Bio-nanotechnology University College Dublin, Irlanda
1998/03/01 - 2006/02/01 Concluído	Licenciatura en Fisica (Licence) Especialização em Physics Universidad de la República Uruguay, Uruguai

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2018/12/01 - Atual	Investigador principal (carreira) (Investigação)	University of St Andrews, Reino Unido

2015/07/01 - 2018/11/30	Pós-doutorado (Investigação)	University of Cambridge Department of Chemistry, Reino Unido

2011/12/01 - 2015/06/30	Pós-doutorado (Investigação)	Institut Interdisciplinaire de Neurosciences, França

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2021/09/01 - Atual	Reader in Biophotonics	University of St Andrews School of Physics and Astronomy, Reino Unido

Projetos

Bolsa

	Designação	Financiadores
2018/12/01 - 2023/11/30	Nanoscale dynamics in the extracellular space of the brain in vivo 804581 Investigador responsável	European Research Council
2020/07/01 - 2023/06/30	Correlating local complexity of the extracellular space of the brain with clearance efficiency of amyloidogenic oligomers 527 (AS-PhD-19a-016) Investigador responsável	Alzheimer's Society Em curso
2019/10/01 - 2021/09/30	Dead-space microdomains in the extracellular space of the brain as traps for amyloid beta oligomers ARUK-PPG2019A-005 Investigador responsável	Alzheimer's Research Trust Em curso

Projeto

	Designação	Financiadores
2013/07/01 - 2015/06/30	DEEP BRAIN TISSUE IMAGING OF GLUTAMATE NMDAR 326442 Bolseiro de Investigação	European Research Council

Produções

Publicações

Artigo em revista

Rodrigues, M.; Bhattacharjee, P.; Brinkmalm, A.; Do, D. T.; Pearson, C. M.; De, S.; Ponjavic, A.; et al. "Structure-specific amyloid precipitation in biofluids". Nature Chemistry 14 9 (2022): 1045-1053. http://dx.doi.org/10.1038/s41557-022-00976-3.
10.1038/s41557-022-00976-3
Varela, Juan. "ThX – a next-generation probe for the early detection of amyloid aggregates". Chemical Science (2020): http://dx.doi.org/10.1039/c9sc04730a.
10.1039/c9sc04730a
Suman De; David C. Wirthensohn; Patrick Flagmeier; Craig Hughes; Francesco A. Aprile; Francesco S. Ruggeri; Daniel R. Whiten; et al. "Different soluble aggregates of Aß42 can give rise to cellular toxicity through different mechanisms". Nature Communications 10 1 (2019): https://doi.org/10.1038/s41467-019-09477-3.
10.1038/s41467-019-09477-3
Juan A. Varela; Margarida Rodrigues; Suman De; Patrick Flagmeier; Sonia Gandhi; Christopher M. Dobson; David Klenerman; Steven F. Lee. "Optical Structural Analysis of Individual a-Synuclein Oligomers". Angewandte Chemie 130 18 (2018): 4980-4984. https://doi.org/10.1002/ange.201710779.
10.1002/ange.201710779
Qamar S; Wang G; Randle SJ; Ruggeri FS; Varela JA; Lin JQ; Phillips EC; et al. "FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-p Interactions.". Cell (2018): http://europepmc.org/abstract/med/29677515.
10.1016/j.cell.2018.03.056
Varela JA; Rodrigues M; De S; Flagmeier P; Gandhi S; Dobson CM; Klenerman D; Lee S. "Optical structural analysis of individual a-synuclein oligomers.". Angewandte Chemie (International ed. in English) (2018): http://europepmc.org/abstract/med/29342318.
10.1002/anie.201710779
Noémie Danné; Antoine G. Godin; Zhenghong Gao; Juan A. Varela; Laurent Groc; Brahim Lounis; Laurent Cognet. "Comparative Analysis of Photoluminescence and Upconversion Emission from Individual Carbon Nanotubes for Bioimaging Applications". ACS Photonics (2017): https://doi.org/10.1021%2Facsphotonics.7b01311.
10.1021/acsphotonics.7b01311
Godin AG; Varela JA; Gao Z; Danné N; Dupuis JP; Lounis B; Groc L; Cognet L. "Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain.". (2016): http://europepmc.org/abstract/med/27870840.
10.1038/nnano.2016.248
Åberg C; Varela JA; Fitzpatrick LW; Dawson KA. "Spatial and Structural Metrics for Living Cells Inspired by Statistical Mechanics.". (2016): http://europepmc.org/abstract/med/27708351.
10.1038/srep34457
Varela, Juan. "Single nanoparticle tracking of N-methyl-D-aspartate receptors in cultured and intact brain tissue.". Neurophotonics (2016): http://europepmc.org/abstract/med/27429996.
10.1117/1.NPh.3.4.041808
Varela, Juan. "Toward the suppression of cellular toxicity from single-walled carbon nanotubes.". Biomaterials Science (2016): http://europepmc.org/abstract/med/26678092.
10.1039/c5bm00134j
Varela, Juan. "Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices.". Nature Communications (2016): http://europepmc.org/abstract/med/26971573.
10.1038/ncomms10947
Murphy-Royal, Ciaran; Dupuis, Julien P; Varela, Juan a; Panatier, Aude; Pinson, Beno\^{\i. "Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission". Nature Neuroscience 18 2 (2015): 219-226. http://www.nature.com/neuro/journal/v18/n2/full/nn.3901.html.
10.1038/nn.3901
Varela, Juan A.; \AA berg, Christoffer; Simpson, Jeremy C.; Dawson, Kenneth A.. "Trajectory-Based Co-Localization Measures for Nanoparticle-Cell Interaction Studies". Small (2014): n/a-n/a. http://doi.wiley.com/10.1002/smll.201401849.
10.1002/smll.201401849
Genin, Emilie; Gao, Zhenghong; Varela, Juan A; Daniel, Jonathan; Bsaibess, Talia; Gosse, Isabelle; Groc, Laurent; Cognet, Laurent; Blanchard-Desce, Mireille. ""Hyper-bright" near-infrared emitting fluorescent organic nanoparticles for single particle tracking.". Advanced Materials 26 14 (2014): 2258-61, 2257. http://doi.wiley.com/10.1002/adma.201304602.
10.1002/adma.201304602
Dupuis, Julien P; Lad\'{e. "Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses.". The EMBO journal 33 8 (2014): 842-61. http://www.ncbi.nlm.nih.gov/pubmed/24591565.
10.1002/embj.201386356
Varela, Juan A; Bexiga, Mariana G; \AA berg, Christoffer; Simpson, Jeremy C; Dawson, Kenneth A. "Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells.". Journal of Nanobiotechnology 10 (2012): 39-39. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3492040\&tool=pmcentrez\&rendertype=abstract.
10.1186/1477-3155-10-39
Salvati, Anna; Aberg, Christoffer; dos Santos, Tiago; Varela, Juan; Pinto, Paulo; Lynch, Iseult; Dawson, Kenneth a. "Experimental and theoretical comparison of intracellular import of polymeric nanoparticles and small molecules: toward models of uptake kinetics.". Nanomedicine : nanotechnology, biology, and medicine 7 6 (2011): 818-26. http://www.ncbi.nlm.nih.gov/pubmed/21453790.
10.1016/j.nano.2011.03.005
dos Santos, Tiago; Varela, Juan; Lynch, Iseult; Salvati, Anna; Dawson, Kenneth A. "Quantitative assessment of the comparative nanoparticle-uptake efficiency of a range of cell lines.". Small 7 23 (2011): 3341-9. http://www.ncbi.nlm.nih.gov/pubmed/22009913.
10.1002/smll.201101076
Varela, Juan. "Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line". Nanotoxicology 5 4 (2011): 557-567. http://www.ncbi.nlm.nih.gov/pubmed/21142842.
10.3109/17435390.2010.539713
dos Santos, Tiago; Varela, Juan; Lynch, Iseult; Salvati, Anna; Dawson, Kenneth A. "Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines.". PloS ONE 6 9 (2011): e24438-e24438. http://www.ncbi.nlm.nih.gov/pubmed/21949717 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3176276\&tool=pmcentrez\&rendertype=abstract.
10.1371/journal.pone.0024438
Cabeza, Cecilia; Varela, Juan; Bove, Italo; Freire, Daniel; Marti´, Arturo C.; Sarasu´a, L. G.; Usera, Gabriel; Montagne, Raul; Araujo, Moacyr. "Two-layer stratified flows over pronounced obstacles at low-to-intermediate Froude numbers". Physics of Fluids 21 4 (2009): 044102-044102. http://scitation.aip.org/content/aip/journal/pof2/21/4/10.1063/1.3110108.
10.1063/1.3110108
Varela, J; Araujo, M; Bove, I; Cabeza, C; Usera, G; Marti, a; Montagne, R; Sarasua, L. "Instabilities developed in stratified flows over pronounced obstacles". Physica A: Statistical Mechanics and its Applications 386 2 (2007): 681-685. http://linkinghub.elsevier.com/retrieve/pii/S0378437107009569.
10.1016/j.physa.2007.08.051

Capítulo de livro

Varela, Juan. "Single Nanoparticle Tracking of Surface Ion Channels and Receptors in Brain Cells". editado por Luj{\'a, 49-58. Springer New York, 2016.
10.1007/978-1-4939-3064-7_5