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Identificação

Identificação pessoal

Nome completo
Joana Bicker de Melo Alves Aparício

Identificadores de autor

Ciência ID
1110-A1AB-626F
Formação
Grau Classificação
2023/11 - 2024/01
Concluído
 Innovation in Teaching 2023 (Outros)
Harvard Business Publishing Education, Estados Unidos
2023/05/22 - 2023/05/26
Concluído
 Introduction to Circadian Biology and Medicine (Outros)
Faculty of Medicine of the University of Lisbon, Portugal
2023/02/01 - 2023/03/15
Concluído
 Seed Tech Transfer: Technology Transfer (Outros)
University of Coimbra, Portugal
2023/01/10
Concluído
 Teaching Excellence Training For Academic Staff - 2nd Edition - 2023 (Outros)
European Network on Teaching Excellence (E-Note), Dinamarca
2022/05/19 - 2022/05/20
Concluído
 Papel del sistema endocannabinoide en la regulación de los transtornos emocionales y las adicciones (Outros)
Conferência IberoAmericana de Faculdades de Farmácia (COIFFA), Guatemala
2022/03/09 - 2022/05/18
Concluído
 Qualitative Methodologies of Scientific Research (Outros)
Especialização em Distance Learning Course
University of Coimbra, Portugal
2018/01/30
Concluído
 PhD in Pharmaceutical Sciences (Doctor)
Especialização em Pharmacology and Pharmacotherapy
University of Coimbra, Portugal
"A Screening Strategy for Evaluation of Drug Transport across the Blood-Brain Barrier: Application to Catechol-O-methyltransferase Inhibitors, Dopamine Beta-hydroxylase Inhibitors and Dibenz[b,f]azepine-5-carboxamide Derivatives" (TESE/DISSERTAÇÃO)
 Approved with Distinction and Praise by Unanimity
2017/10/17
Concluído
 Investigator-Coordinator in Animal Sciences (EU Function A+B+D) (Outros)
Directorate-General of Food and Veterinary Medicine (DGAV), Portugal
2017/07/12
Concluído
 Practical Course in Laboratory Animal Science (Outros)
Portuguese Society of Science in Laboratory Animals (SPCAL), Portugal
2015/10/09
Concluído
 6th Course on the BBB in Drug Development "Principles, Transport Kinetics, Diseases & Methods" (Outros)
University of Uppsala, Suécia
2015/02
Concluído
 Theoretical Course in Laboratory Animal Science (Outros)
Portuguese Society of Science in Laboratory Animals (SPCAL), Portugal
2014/11/28
Concluído
 Methodology of Scientific Research and Data Analysis (Outros)
Portuguese Society of Science in Laboratory Animals (SPCAL), Portugal
2014/03/14
Concluído
 Hands-On Course on Microscopy Imaging Analysis (Outros)
University of Coimbra - Centre for Neuroscience and Cell Biology (CNC), Portugal
2013/07/19
Concluído
 Cell Culture and Tissue Course - Beyond the Microscope, culturing Life (Outros)
iCBR - Coimbra Institute for Clinical and Biomedical Research., Portugal
2012/12/18
Concluído
 VII Course of Determination of Drugs by HPLC in Biological Samples (Outros)
University of Salamanca - Department of Pharmacy and Pharmaceutical Technology, Espanha
2012/06/22
Concluído
 Challenges of Communication in Science (Outros)
University of Coimbra - Centre for Neuroscience and Cell Biology (CNC), Portugal
2012/04/13
Concluído
 Animal Models of Human Diseases (Outros)
iCBR - Coimbra Institute for Clinical and Biomedical Research., Portugal
2011/11/11
Concluído
 Immunology (Outros)
University of Coimbra - Centre for Neuroscience and Cell Biology (CNC), Portugal
2006/09 - 2011/07
Concluído
 Integrated Master's in Pharmaceutical Sciences (Master)
University of Coimbra - Faculty of Pharmacy, Portugal
"Professional Intership Report and Monograph (Importance of in silico ADME assessment in drug development)" (TESE/DISSERTAÇÃO)
 16
2011/02/19
Concluído
 Updates in Neurology (Outros)
Portuguese Association of Hospital Pharmacists, Portugal
2004
Concluído
 Certificate of Proficiency in English (CPE) (Outros)
University of Cambridge, Reino Unido
2003
Concluído
 First Certificate in English (FCE) (Outros)
University of Cambridge, Reino Unido
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02 - 2022/02 Pós-doutorado (Investigação) University of Coimbra, Portugal
Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Portugal
(...)
2009/04 - 2010/03 Estagiário de Investigação (Investigação) University of Coimbra - Centre for Neuroscience and Cell Biology (CNC), Portugal
University of Coimbra - Centre for Neuroscience and Cell Biology (CNC), Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/09/01 - Atual Professor Auxiliar Convidado (Docente Universitário) University of Coimbra - Faculty of Pharmacy, Portugal
University of Coimbra - Faculty of Pharmacy, Portugal
2018/09/01 - 2019/08/31 Professor Auxiliar Convidado (Docente Universitário) University of Coimbra - Faculty of Pharmacy, Portugal
University of Coimbra - Faculty of Pharmacy, Portugal
2017/09/01 - 2018/08/31 Professor Auxiliar Convidado (Docente Universitário) University of Coimbra - Faculty of Pharmacy, Portugal
University of Coimbra - Faculty of Pharmacy, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2012/01/01 - 2018/01/30 PhD Student University of Coimbra - Faculty of Pharmacy, Portugal
University of Coimbra - Centre for Neuroscience and Cell Biology (CNC), Portugal
2015/09 - 2016/01 Teaching Adjunct University of Coimbra - Faculty of Pharmacy, Portugal
Laboratory of Pharmacology and Pharmaceutical Care - Faculty of Pharmacy of the University of Coimbra, Portugal
2014/09 - 2015/01 Teaching Adjunct University of Coimbra - Faculty of Pharmacy, Portugal
Laboratory of Pharmacology and Pharmaceutical Care - Faculty of Pharmacy of the University of Coimbra, Portugal
2011/01 - 2011/07 Internship (Professional Internship) Pharmacy São José, Portugal
2010/07 - 2010/08 Internship (Extracurricular Internship) Laboratory of Clinical Analysis Virgílio Roldão, Portugal
2009/07 - 2009/08 Internship (Extracurricular Internship) Pharmacy Duarte, Portugal
2008/07 - 2008/08 Internship (Extracurricular Internship) Pharmacy Guardiano, Portugal
Projetos

Projeto

Designação Financiadores
2019/02 - 2022/02 4Epilepsy: Promoting the quality-of-life of epileptic patients through personalized medicine
POCI-01-0145-FEDER-030478
Investigador
University of Coimbra - Faculty of Pharmacy, Portugal

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Foundation for Science and Technology (FCT)
Concluído
2012/01/01 - 2018/01/30 Screening Strategy for Evaluation of Drug Transport across the Blood-Brain Barrier: Application to Catechol-O-methyltransferase Inhibitors, Dopamine ß-hydroxylase Inhibitors and Dibenz[b,f]azepine-5-carboxamide Derivatives
SFRH/BD/78256/2011
Bolseiro de Doutoramento
University of Coimbra - Faculty of Pharmacy, Portugal

University of Coimbra - Centre for Neuroscience and Cell Biology (CNC), Portugal
Foundation for Science and Techology (FCT)
Concluído

Outro

Designação Financiadores
2023/03/17 - Atual EpiMod: Epigenetic modulation of blood-brain barrier integrity for the prevention of epileptogenesis
2022.03133.PTDC
Investigador responsável
University of Coimbra - Faculty of Pharmacy, Portugal

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Portugal
Em curso
2023/01/01 - Atual Prenatal tryptophan as a key player in gut-brain axis dysfunction: an autism spectrum disorder preclinical approach
2022.01066.PTDC
Investigador
Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Portugal
Em curso
2022/07/01 - Atual MitoBOOST v2.0
01/SAICT/2021
Investigador
Biocant Associação de Transferência de Tecnologia, Portugal
Em curso
2022/04 - 2024/01 Targeted Therapeutics for Glioblastoma Multiforme (TargTex SA)
.
Investigador
University of Coimbra - Faculty of Pharmacy, Portugal

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Portugal
Concluído
2022/05 - 2023/02 Development and validation of a liquid chromatography method to quantify metformin in rat biological samples
.
Investigador
University of Coimbra - Faculty of Pharmacy, Portugal
Concluído
2018 - 2021 N2BD: Development of a Novel Nose-to-Brain Multifunctional Nanoplatform for the Treatment of Depression and Prevention of Pharmacoresistance Development
CENTRO-01-0145-FEDER-030752- N2BD
Investigador
University of Coimbra - Faculty of Pharmacy, Portugal

Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Portugal
Foundation for Science and Technology (FCT)
Concluído
Produções

Publicações

Artigo em conferência
  1. Henriques, Patrícia; Bicker, Joana; Doktorovová, Slavomíra; Fortuna, Ana. "Nasal-PAMPA: a novel in vitro tool for prediction of intranasal drug permeability". Trabalho apresentado em Drug Delivery to the Lungs Conference: The Aerosol Society, Edinburgh, 2021.
    Publicado
  2. Vitorino, Carla; Silva, Soraia; Bicker, Joana; Carona, Andreia; Falcão, Amílcar; Fortuna, Ana. "Designing lipid nanoparticles for intranasal delivery of antidepressants". Trabalho apresentado em Drug Delivery to the Lungs Conference: The Aerosol Society, Edinburgh, 2019.
    Publicado
Artigo em revista
  1. Silva, Rui; Colom, Helena; Almeida, Anabela; Bicker, J; Carona, Andreia; Silva, Ana; Sales, Francisco; et al. "A new population pharmacokinetic model for dosing optimization of zonisamide in patients with refractory epilepsy". European Journal of Pharmaceutical Sciences 207 (2025): 107023. https://doi.org/10.1016/j.ejps.2025.107023.
    10.1016/j.ejps.2025.107023
  2. Rodrigues, Beatriz; Ventura, Eduarda; Moreira, Patrícia; Resende, Rosa; Bicker, J; Santos, Armanda E.; Pereira, Cláudia Fragão; et al. "New low-dose curcumin derivative with therapeutic potential in Alzheimer’s disease: Results from an in vitro and in vivo study in mice". Neurobiology of Aging 147 (2025): 105-123. https://doi.org/10.1016/j.neurobiolaging.2024.12.005.
    10.1016/j.neurobiolaging.2024.12.005
  3. Moreira, Patrícia; Macedo, Jéssica; Matos, Patrícia; Bicker, J; Fortuna, Ana; Figueirinha, Artur; Salgueiro, Lígia; et al. "Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease". Biomedicine & Pharmacotherapy 181 (2024): 117652. http://dx.doi.org/10.1016/j.biopha.2024.117652.
    10.1016/j.biopha.2024.117652
  4. Gouveia, Filipa; Carona, Andreia; Lacerda, Mariana; Bicker, J; Camins, Antoni; Teresa Cruz, M.; Ettcheto, Miren; Falcão, Amílcar; Fortuna, Ana. "Unveiling the potential of intranasal delivery of renin-angiotensin system drugs: Insights on the pharmacokinetics of irbesartan". Biochemical Pharmacology 230 (2024): 116616. https://doi.org/10.1016/j.bcp.2024.116616.
    10.1016/j.bcp.2024.116616
  5. Amaral, Maiara; Romanelli, Maiara M.; Asiki, Hannah; Bicker, J; Lage, Daniela P.; Freitas, Camila S.; Taniwaki, Noemi N.; et al. "Synthesis of a dehydrodieugenol B derivative as a lead compound for visceral leishmaniasis—mechanism of action and in vivo pharmacokinetic studies". Antimicrobial Agents and Chemotherapy (2024): http://dx.doi.org/10.1128/aac.00831-24.
    10.1128/aac.00831-24
  6. Cordeiro, Ana; Gomes, Catarina; Bicker, J; Fortuna, Ana. "Aging and cognitive resilience: Molecular mechanisms as new potential therapeutic targets". Drug Discovery Today 29 9 (2024): 104093. http://dx.doi.org/10.1016/j.drudis.2024.104093.
    10.1016/j.drudis.2024.104093
  7. Cunha, Susana; Bicker, J; Sereno, José; Falcão, Amílcar; Fortuna, Ana. "Blood brain barrier dysfunction in healthy aging and dementia: Why, how, what for?". Ageing Research Reviews 99 (2024): 102395. http://dx.doi.org/10.1016/j.arr.2024.102395.
    10.1016/j.arr.2024.102395
  8. Pereira, Márcia; Cruz, Maria Teresa; Fortuna, Ana; Bicker, J. "Restoring the epigenome in Alzheimer's disease: advancing HDAC inhibitors as therapeutic agents". Drug Discovery Today 29 7 (2024): 104052. http://dx.doi.org/10.1016/j.drudis.2024.104052.
    10.1016/j.drudis.2024.104052
  9. Silva, Soraia; Bicker, J; Fialho, S.; Cunha, Susana; Falcão, Amílcar; Fortuna, Ana. "Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences". Biochemical Pharmacology 223 (2024): 116184. http://dx.doi.org/10.1016/j.bcp.2024.116184.
    Publicado • 10.1016/j.bcp.2024.116184
  10. Santos, Ana Beatriz; Carona, Andreia; Ettcheto, Miren; Camins, Antoni; Falcão, Amílcar; Fortuna, Ana; Bicker, Joana. "Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis". Acta Pharmacologica Sinica (2024): http://dx.doi.org/10.1038/s41401-024-01285-w.
    Publicado • 10.1038/s41401-024-01285-w
  11. Silva, Soraia; Fonseca, Carla; Bicker, J; Falcão, Amílcar; Fortuna, Ana. "Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression". European Journal of Pharmaceutics and Biopharmaceutics 194 (2024): 118-130. http://dx.doi.org/10.1016/j.ejpb.2023.12.002.
    Publicado • 10.1016/j.ejpb.2023.12.002
  12. Carona, Andreia; Bicker, J; Fonseca, Carla; da Graça Campos, Maria; Falcão, Amílcar; Fortuna, Ana. "Development and validation of an HPLC-DAD method for the quantification of cannabigerol, cannabidiol, cannabinol and cannabichromene in human plasma and mouse matrices". The Analyst 149 14 (2024): 3815-3827. http://dx.doi.org/10.1039/d4an00070f.
    10.1039/d4an00070f
  13. Olloquequi, Jordi; Ettcheto, Miren; Cano, Amanda; Fortuna, Ana; Bicker, J; Sánchez-Lopez, Elena; Paz, Cristian; et al. "Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment". International Journal of Molecular Sciences 24 18 (2023): 14177. http://dx.doi.org/10.3390/ijms241814177.
    Publicado • 10.3390/ijms241814177
  14. Henriques, Patrícia; Bicker, J; Carona, Andreia; Miranda, Margarida; Vitorino, Carla; Doktorovová, Slavomíra; Fortuna, Ana. "Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics". Journal of Pharmaceutical Investigation 53 5 (2023): 723-742. http://dx.doi.org/10.1007/s40005-023-00630-1.
    Publicado • 10.1007/s40005-023-00630-1
  15. Henriques, Patrícia; Bicker, J; Silva, Soraia; Doktorovová, Slavomíra; Fortuna, Ana. "Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability". International Journal of Pharmaceutics 643 (2023): 123252. http://dx.doi.org/10.1016/j.ijpharm.2023.123252.
    Publicado • 10.1016/j.ijpharm.2023.123252
  16. Fonseca, Carla; Ettcheto, Miren; Bicker, J; Fernandes, Maria José; Falcão, Amílcar; Camins, Antoni; Fortuna, Ana. "Under the umbrella of depression and Alzheimer's disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?". Ageing Research Reviews 90 (2023): 101998. http://dx.doi.org/10.1016/j.arr.2023.101998.
    Publicado • 10.1016/j.arr.2023.101998
  17. Silva, Rui; Colom, Helena; Bicker, J; Almeida, Anabela; Silva, Ana; Sales, Francisco; Santana, Isabel; Falcão, Amílcar; Fortuna, Ana. "Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy". Pharmaceutics 15 6 (2023): 1704. http://dx.doi.org/10.3390/pharmaceutics15061704.
    Publicado • 10.3390/pharmaceutics15061704
  18. Silva, Soraia; Bicker, J; Falcão, Amílcar; Fortuna, Ana. "Air-liquid interface (ALI) impact on different respiratory cell cultures". European Journal of Pharmaceutics and Biopharmaceutics 184 (2023): 62-82. http://dx.doi.org/10.1016/j.ejpb.2023.01.013.
    Publicado • 10.1016/j.ejpb.2023.01.013
  19. Aquino, Maria; Tinoco, Maria; Bicker, J; Falcão, Amílcar; Rocha, Marília; Fortuna, Ana. "Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients". Antibiotics 12 2 (2023): 373. http://dx.doi.org/10.3390/antibiotics12020373.
    Publicado • 10.3390/antibiotics12020373
  20. Silva, Rui; Bicker, J; Almeida, Anabela; Carona, Andreia; Silva, Ana; Sales, Francisco; Santana, Isabel; Falcão, Amílcar; Fortuna, Ana. "Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients". Biomedicines 10 9 (2022): 2127. http://dx.doi.org/10.3390/biomedicines10092127.
    Publicado • 10.3390/biomedicines10092127
  21. Gouveia, Filipa; Camins, Antoni; Ettcheto, Miren; Bicker, Joana; Falcão, Amílcar; Cruz, M. Teresa; Fortuna, Ana. "Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future". Ageing Research Reviews 77 (2022): 101612. http://dx.doi.org/10.1016/j.arr.2022.101612.
    Publicado • 10.1016/j.arr.2022.101612
  22. Silva, Soraia; Bicker, Joana; Fonseca, Carla; Ferreira, Nuno; Vitorino, Carla; Alves, Gilberto; Falcäo, Amílcar; Fortuna, Ana. "Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation". Frontiers in Pharmacology (2021): https://www.frontiersin.org/articles/10.3389/fphar.2021.751321/full.
    Publicado • 10.3389/fphar.2021.751321
  23. Silva, Soraia; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression". Pharmaceutics 13 11 (2021): 1975. http://dx.doi.org/10.3390/pharmaceutics13111975.
    Publicado • 10.3390/pharmaceutics13111975
  24. Carona, Andreia; Bicker, Joana; Silva, Rui; Fonseca, Carla; Falcão, Amílcar; Fortuna, Ana. "Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications". Life Sciences (2021): 119342. http://dx.doi.org/10.1016/j.lfs.2021.119342.
    Publicado • 10.1016/j.lfs.2021.119342
  25. Carona, Andreia; Bicker, Joana; Silva, Rui; Silva, Ana; Santana, Isabel; Sales, Francisco; Falcão, Amílcar; Fortuna, Ana. "HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring". Journal of Pharmaceutical and Biomedical Analysis (2021): 113961. http://dx.doi.org/10.1016/j.jpba.2021.113961.
    Publicado • 10.1016/j.jpba.2021.113961
  26. Gonçalves, Joana; Silva, Soraia; Gouveia, Filipa; Bicker, Joana; Falcão, Amílcar; Alves, Gilberto; Fortuna, Ana. "A combo-strategy to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration". International Journal of Pharmaceutics 593 (2021): 120161. http://dx.doi.org/10.1016/j.ijpharm.2020.120161.
    Publicado • 10.1016/j.ijpharm.2020.120161
  27. Sabença, Rosa; Bicker, Joana; Silva, Rui; Carona, Andreia; Silva, Ana; Santana, Isabel; Sales, Francisco; Falcão, Amílcar; Fortuna, Ana. "Development and application of an HPLC-DAD technique for human plasma concentration monitoring of perampanel and lamotrigine in drug-resistant epileptic patients". Journal of Chromatography B 1162 (2021): 122491. http://dx.doi.org/10.1016/j.jchromb.2020.122491.
    Publicado • 10.1016/j.jchromb.2020.122491
  28. Bicker, Joana; Alves, Gilberto; Fonseca, Carla; Falcão, Amílcar; Fortuna, Ana. "Repairing blood-CNS barriers: Future therapeutic approaches for neuropsychiatric disorders". Pharmacological Research 162 (2020): 105226. http://dx.doi.org/10.1016/j.phrs.2020.105226.
    Publicado • 10.1016/j.phrs.2020.105226
  29. Gonçalves, Joana; Alves, Gilberto; Fonseca, Carla; Carona, Andreia; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "Is intranasal administration an opportunity for direct brain delivery of lacosamide?". European Journal of Pharmaceutical Sciences (2020): 105632. http://dx.doi.org/10.1016/j.ejps.2020.105632.
    Publicado • 10.1016/j.ejps.2020.105632
  30. Silva, Rui; Almeida, Anabela; Bicker, Joana; Gonçalves, Joana; Carona, Andreia; Silva, Ana; Santana, Isabel; et al. "Pharmacokinetic Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy". Pharmaceutics 12 10 (2020): 943. http://dx.doi.org/10.3390/pharmaceutics12100943.
    Publicado • 10.3390/pharmaceutics12100943
  31. Fonseca, Carla; Bicker, Joana; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "Cystic fibrosis: Physiopathology and the latest pharmacological treatments". Pharmacological Research (2020): 105267. http://dx.doi.org/10.1016/j.phrs.2020.105267.
    Publicado • 10.1016/j.phrs.2020.105267
  32. Vitorino, Carla; Silva, Soraia; Gouveia, Filipa; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "QbD-driven development of intranasal lipid nanoparticles for depression treatment". European Journal of Pharmaceutics and Biopharmaceutics 153 (2020): 106-120. http://dx.doi.org/10.1016/j.ejpb.2020.04.011.
    Publicado • 10.1016/j.ejpb.2020.04.011
  33. Gonçalves, Joana; Alves, Gilberto; Carona, Andreia; Bicker, Joana; Vitorino, Carla; Falcão, Amílcar; Fortuna, Ana. "Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration". Pharmaceutical Research 37 4 (2020): http://dx.doi.org/10.1007/s11095-020-02786-z.
    Publicado • 10.1007/s11095-020-02786-z
  34. Bicker, Joana; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "Timing in drug absorption and disposition: the past, present and future of chronopharmacokinetics". British Journal of Pharmacology (2020): http://dx.doi.org/10.1111/bph.15017.
    Publicado • 10.1111/bph.15017
  35. Bicker, Joana; Fortuna, Ana; Alves, Gilberto; Falcão, Amílcar. "Nose-to-brain delivery of natural compounds for the treatment of central nervous system disorders". Current Pharmaceutical Design 26 (2020): http://dx.doi.org/10.2174/1381612826666200115101544.
    Publicado • 10.2174/1381612826666200115101544
  36. Moreira, Rita S.; Bicker, Joana; Musicco, Felice; Persichetti, Agnese; Pereira, André M.P.T.. "Anti-PD-1 immunotherapy in advanced metastatic melanoma: State of the art and future challenges". Life Sciences 240 (2020): 117093. http://dx.doi.org/10.1016/j.lfs.2019.117093.
    Publicado • 10.1016/j.lfs.2019.117093
  37. Gouveia, Filipa; Bicker, Joana; Santos, Joana; Rocha, Marília; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "Development, validation and application of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma". Journal of Pharmaceutical and Biomedical Analysis 181 (2020): 113109. http://dx.doi.org/10.1016/j.jpba.2020.113109.
    Publicado • 10.1016/j.jpba.2020.113109
  38. Gouveia, Filipa; Bicker, Joana; Gonçalves, Joana; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "Liquid chromatographic methods for the determination of direct oral anticoagulant drugs in biological samples: A critical review". Analytica Chimica Acta 1076 (2019): 18-31. http://dx.doi.org/10.1016/j.aca.2019.03.061.
    Publicado • 10.1016/j.aca.2019.03.061
  39. Vitorino, Carla; Silva, Soraia; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges". Drug Discovery Today 24 9 (2019): 1911-1923. http://dx.doi.org/10.1016/j.drudis.2019.06.001.
    Publicado • 10.1016/j.drudis.2019.06.001
  40. Gonçalves, Joana; Bicker, Joana; Gouveia, Filipa; Liberal, Joana; Oliveira, Rui Caetano; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "Nose-to-brain delivery of levetiracetam after intranasal administration to mice". International Journal of Pharmaceutics 564 (2019): 329-339. http://dx.doi.org/10.1016/j.ijpharm.2019.04.047.
    Publicado • 10.1016/j.ijpharm.2019.04.047
  41. Leandro, Kevin; Bicker, Joana; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "ABC transporters in drug-resistant epilepsy: mechanisms of upregulation and therapeutic approaches". Pharmacological Research 144 (2019): 357-376. http://dx.doi.org/10.1016/j.phrs.2019.04.031.
    Publicado • 10.1016/j.phrs.2019.04.031
  42. Bicker, Joana; Alves, Gilberto; Fortuna, Ana; Soares-da-Silva, Patrício; Falcão, Amílcar. "In vitro assessment of the interactions of dopamine ß-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein". European Journal of Pharmaceutical Sciences 117 - (2018): 35-40. http://dx.doi.org/10.1016/j.ejps.2018.02.006.
    Publicado • 10.1016/j.ejps.2018.02.006
  43. Gonçalves, Joana; Alves, Gilberto; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "Development and full validation of an innovative HPLC-diode array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma". Bioanalysis 10 8 (2018): 541-557. https://doi.org/10.4155/bio-2017-0199.
    Publicado • 10.4155/bio-2017-0199
  44. Goncalves, Joana; Bicker, Joana; Alves, Gilberto; Fortuna, Ana; Falcao, Amilcar. "Relevance of Breast Cancer Resistance Protein to brain distribution and central acting drugs: a pharmacokinetic perspective". Current Drug Metabolism 19 12 (2018): 1021-1041.
    Publicado • 10.2174/1389200219666180629121033
  45. Bicker, Joana; Fortuna, Ana; Alves, Gilberto; Soares-da-Silva, Patrício; Falcão, Amílcar. "Elucidation of the impact of P-glycoprotein and Breast Cancer Resistance Protein on the brain distribution of catechol-O-methyltransferase inhibitors". Drug Metabolism and Disposition 45 12 (2017): 1282-1291. https://doi.org/10.1124/dmd.117.077883.
    Publicado • 10.1124/dmd.117.077883
  46. Matias, Mariana; Fortuna, Ana; Bicker, Joana; Silvestre, Samuel; Falcão, Amílcar; Alves, Gilberto. "Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in vitro and in silico assays". European Journal of Pharmaceutical Sciences 109 (2017): 334-346. https://doi.org/10.1016/j.ejps.2017.08.023.
    Publicado • 10.1016/j.ejps.2017.08.023
  47. Bicker, Joana; Alves, Gilberto; Fortuna, Ana; Soares-da-Silva, Patrício; Falcão, Amílcar. "A new PAMPA model using an in-house brain lipid extract for screening the blood-brain barrier permeability of drug candidates". International Journal of Pharmaceutics 501 1-2 (2016): 102-111. https://doi.org/10.1016/j.ijpharm.2016.01.074.
    Publicado • 10.1016/j.ijpharm.2016.01.074
  48. Bicker, Joana; Alves, Gilberto; Fortuna, Ana; Falcão, Amílcar. "Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review". European Journal of Pharmaceutics and Biopharmaceutics 87 3 (2014): 409-432. https://doi.org/10.1016/j.ejpb.2014.03.012.
    Publicado • 10.1016/j.ejpb.2014.03.012
  49. Bicker, Joana; Fortuna, Ana; Alves, Gilberto; Falcão, Amílcar. "Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several biological samples - a review". Analytica Chimica Acta 768 - (2013): 12-34. https://doi.org/10.1016/j.aca.2012.12.030.
    Publicado • 10.1016/j.aca.2012.12.030
  50. Fortuna, Ana; Bicker, Joana; Alves, Gilberto; Falcão, Amílcar; Soares-da-Silva, Patrício. "A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5-carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites". Journal of Separation Science 34 12 (2011): 1391-1401. https://doi.org/10.1002/jssc.201100099.
    Publicado • 10.1002/jssc.201100099
Capítulo de livro
  1. Bicker, Joana; Fortuna, Ana; Alves, Gilberto; Falcäo, Amílcar. "Understanding Brain Delivery". In Nanoparticles for Brain Drug Delivery, 9-38. Jenny Stanford Publishing, 2021.
    Publicado • 10.1201/9781003119326-3
  2. Serralheiro, Ana; Bicker, Joana; Alves, Gilberto; Falcäo, Amílcar; Fortuna, Ana. "Novel Routes to Accessing the Brain: Intranasal Administration". In Nanoparticles for Brain Drug Delivery, 39-72. Jenny Stanford Publishing, 2021.
    Publicado • 10.1201/9781003119326-4
Poster em conferência
  1. Carona, Andreia; Bicker, Joana; Cunha, Susana; Gouveia, Filipa; Fonseca, Carla; Falcão, Amílcar; Fortuna, Ana. "HPLC-DAD technique for the quantification of cannabinoids in human plasma and mouse matrices". Trabalho apresentado em PharmaDay: One Health, 2023.
  2. Gouveia, Filipa; Bicker, J; Carona, Andreia; Ettcheto, Miren; Cruz, Maria Teresa; Fortuna, Ana. "Ultra High Performance Liquid Chromatography Technique to support Pharmacokinetic Monitoring of Losartan, Irbesartan and Valsartan". Trabalho apresentado em X Iberoamerican Pharmaceutical Sciences Congress, 2023.
  3. Carona, Andreia; Bicker, Joana; Fonseca, Carla; Falcão, Amílcar; Fortuna, Ana. "High Performance Liquid Chromatography Technique for the Quantification of Cannabigerol, Cannabidiol, Cannabinol and Cannabichromene in Human Plasma and Mouse Matrices". Trabalho apresentado em Medical Cannabis Coimbra, 2023.
  4. Fonseca, Carla; Ettcheto, Miren; Camins, Antoni; Ferreira, Ricardo; Bicker, Joana; Barbosa, Rui ; Fortuna, Ana. "New HPLC technology for monitoring neurotransmitters in the brain: a pre-clinical approach for neurological disorders". Trabalho apresentado em International Multi-Brain Barcelona Congress «Healthy, Pathological and Artificial Brain», 2022.
  5. Fonseca, Luís; Silva, Rui; Almeida, Anabela; Bicker, Joana; Sales, Francisco; Bento, Conceição; Silva, Ana; Falcão, Amílcar; Fortuna, Ana. "Characterization of the pharmacokinetic profile of perampanel in portuguese epileptic patients". Trabalho apresentado em 34th National Meeting of Epilepsy, 2022.
  6. Henriques, Patrícia; Bicker, Joana; Doktorovová, Slavomíra; Fortuna, Ana. "Nasal-PAMPA: a novel in vitro tool for the prediction of intranasal drug permeability and its application to formulations of a poorly-soluble drug". Trabalho apresentado em 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (Virtual), 2021.
  7. Carona, Andreia; Bicker, Joana; Silva, Rui; Silva, Ana; Santana, Isabel; Sales, Francisco; Falcão, Amílcar; Fortuna, Ana. "Quantification of antiepileptic drugs in human saliva as a new tool for therapeutic drug monitoring". Trabalho apresentado em 33º National Meeting of Epilepsy (Lisbon, Portugal), 2021.
  8. Silva, Soraia; Vitorino, Carla; Gonçalves, Joana; Carona, Andreia; Bicker, Joana; Falcão, Amílcar; Fortuna, Ana. "Application of in vitro nasal model for antidepressant drug permeation studies". Trabalho apresentado em 1st Annual Meeting in Pharmaceutical Sciences (Coimbra, Portugal), 2019.
  9. Silva, Rui; Almeida, Ana; Bicker, Joana; Carona, Andreia; Sales, Francisco; Bento, Conceição; Falcão, Amílcar; Fortuna, Ana. "Pharmacokinetic data model on assessing adherence to levetiracetam". Trabalho apresentado em 48th Symposium of European Society of Clinical Pharmacy (ESCP) (Ljubljana, Slovenia), 2019.
  10. Gonçalves, Joana; Bicker, Joana; Silva, Soraia; Alves, Gilberto; Falcão, Amílcar; Fortuna, Ana. "Nose-to-brain delivery of levetiracetam: preclinical evidence". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) (Coimbra, Portugal), 2019.
  11. Gonçalves, Joana; Silva, Rui; Almeida, Anabela; Bicker, Joana; Silva, Ana; Sales, Francisco; Falcão, Amílcar; Fortuna, Ana. "Therapeutic drug monitoring of levetiracetam: pharmacokinetic characterization and compliance assessment of epileptic patients". Trabalho apresentado em 53rd Annual Scientific Meeting of the European Society for Clinical Investigation (Coimbra, Portugal), 2019.
  12. Matias, Mariana; Fortuna, Ana; Bicker, Joana; Falcão, Amílcar; Silvestre, Samuel; Alves, Gilberto. "Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)ones derivatives using in vitro and in silico assays". Trabalho apresentado em XII CICS-UBI Symposium (Covilhã, Portugal), 2017.
  13. Bicker, Joana; Barreto, Sandra; Alves, Gilberto; Salgueiro, Lígia; Cavaleiro, Carlos; Fortuna, Ana; Falcão, Amílcar. "Identification of P-glycoprotein inhibitors in Caco-2 cells: an in vitro screening methodology". Trabalho apresentado em 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (Lisbon, Portugal), 2014.
  14. Bicker, Joana; Alves, Gilberto; Fortuna, Ana; Falcão, Amílcar. "Development of a new PAMPA method for the prediction of blood-brain barrier permeation using an in-house brain lipid extract". Trabalho apresentado em 17th International Symposium on Signal Transduction at the Blood-Brain and Blood-Retina Barriers (Dublin, Ireland), 2014.
  15. Gonçalves, Daniela; Alves, Gilberto; Fortuna, Ana; Bicker, Joana; Soares-da-Silva, Patrício; Falcão, Amílcar. "Development of HPLC-DAD method for determination of opicapone and its active metabolite in rat matrices". Trabalho apresentado em IV Conference of the Centre of Pharmaceutical Studies (Coimbra, Portugal), 2013.
  16. Rodrigues, Márcio; Alves, Gilberto; Bicker, Joana; Ferreira, Ana; Queiroz, João A; Falcão, Amílcar. "A simple procedure for the monitoring of amiodarone and desethylamiodarone by HPLC-DAD detection: application to clinical toxicology". Trabalho apresentado em I Iberian Journeys of Toxicology (Covilhã, Portugal), 2011.
  17. Serralheiro, Ana; Bicker, Joana; Fortuna, Ana; Alves, Gilberto; Falcão, Amílcar. "Drug monitoring and clinical toxicology: a simple procedure for the monitoring of six antiepileptic drugs by HPLC-UV detection". Trabalho apresentado em I Iberian Journeys of Toxicology (Covilhã, Portugal), 2011.
  18. Rodrigues, Márcio; Alves, Gilberto; Bicker, Joana; Ferreira, Ana; Queiroz, João A; Falcão, Amílcar. "Simultaneous determination of amiodarone and desethylamiodarone by HPLC-DAD in plasma and heart tissue of rat". Trabalho apresentado em IV Ibero-American Congress of Pharmaceutical Sciences (Lisbon, Portugal), 2011.
  19. Rodrigues, Márcio; Alves, Gilberto; Bicker, Joana; Ferreira, Ana; Queiroz, João A; Falcão, Amílcar. "Fast HPLC-DAD method for the determination of amiodarone and desethylamiodarone in liver, kidney and lung tissues of rat". Trabalho apresentado em IV Ibero-American Congress of Pharmaceutical Sciences (Lisbon, Portugal), 2011.
  20. Sousa, Joana; Bicker, Joana; Alves, Gilberto; Fortuna, Ana; Pena, Angelina; Lino, Celeste; Falcão, Amílcar. "Determination of norfloxacin, ciprofloxacin and lomefloxacin in human plasma by a simple and rapid liquid chromatographic method". Trabalho apresentado em IV Ibero-American Congress of Pharmaceutical Sciences (Lisbon, Portugal), 2011.
  21. Serralheiro, Ana; Bicker, Joana; Fortuna, Ana; Alves, Gilberto; Falcão, Amílcar. "Novel HPLC-UV method to monitor plasma concentrations of six antiepileptic drugs and three of their main metabolites in patients with epilepsy". Trabalho apresentado em IV Ibero-American Congress of Pharmaceutical Sciences (Lisbon, Portugal), 2011.
  22. Fortuna, Ana; Bicker, Joana; Mesquita, Inês; Alves, Gilberto; Falcão, Amílcar; Soares-da-Silva, Patrício. "A rapid and robust HPLC-UV method for simultaneous quantification of three generations of anti-epileptic drugs in human plasma: carbamazepine, oxcarbazepine and eslicarbazepine acetate". Trabalho apresentado em IV Ibero-American Congress of Pharmaceutical Sciences (Lisbon, Portugal), 2011.
  23. Fortuna, Ana; Bicker, Joana; Mesquita, Inês; Alves, Gilberto; Falcão, Amílcar; Soares-da-Silva, Patrício. "Development of an enantioselective high-performance liquid chromatography analysis of dibenz/b,f/azepine-5-carboxamide derivatives in mouse plasma and brain". Trabalho apresentado em IV Ibero-American Congress of Pharmaceutical Sciences (Lisbon, Portugal), 2011.
  24. Fortuna, Ana; Bicker, Joana; Mesquita, Inês; Alves, Gilberto; Falcão, Amílcar. "Predicting human drug absorption with Parallel Artificial Membrane Permeability Assay". Trabalho apresentado em IV Ibero-American Congress of Pharmaceutical Sciences (Lisbon, Portugal), 2011.
  25. Fortuna, Ana; Bicker, Joana; Mesquita, Inês; Alves, Gilberto; Falcão, Amílcar. "Assessment of the involvement of P-glycoprotein in intestinal drug absorption during drug discovery". Trabalho apresentado em IV Ibero-American Congress of Pharmaceutical Sciences (Lisbon, Portugal), 2011.
Resumo em conferência
  1. Silva, Rui; Fonseca, Luís; Almeida, Anabela; Bicker, Joana; Sales, Francisco; Falcäo, Amílcar; Fortuna, Ana. "Is the pharmacokinetics of perampanel influenced by gender and comedication in refractory epileptic patients?". Trabalho apresentado em 49th ESCP virtual symposium on Clinical Pharmacy, 2021.
    Publicado
  2. Silva, Rui; Almeida, Anabela; Bicker, Joana; Carona, Andreia; Sales, Francisco; Bento, Conceição; Falcão, Amílcar; Fortuna, Ana. "Pharmacokinetic data model on assessing adherence to levetiracetam". Trabalho apresentado em 48th ESCP symposium on Clinical Pharmacy, Ljubljana, 2019.
    Publicado
  3. Silva, Rui; Almeida, Anabela; Fonseca, Luís; Gonçalves, Joana; Bicker, Joana; Sales, Francisco; Bento, Conceição; et al. "Evaluation of adherence to treatment of epileptic patients administered with levetiracetam with resort to therapeutic monitoring". Trabalho apresentado em Sinapse, Lisbon, 2019.
    Publicado

Propriedade Intelectual

Patente
  1. Cruz, Maria Teresa; Fortuna, Ana; Bicker, Joana. 2022. "Patent number: PCT/IB2022/052060 (Small Molecules For Use In Preventing And/Or Treatment Of Neurodegenerative Disease)".
  2. Fortuna, Ana; Vitorino, Carla; Bicker, Joana; Falcao, Amilcar. 2022. "Patent number: PCT/IB2022/061847 (Intranasal Administration For A Sustained Brain Delivery Of Highly Protein-Bound Drugs)".
    Concedida/Emitida
Distinções

Prémio

2023 Innovation in Teaching 2023
Harvard Business Publishing Education, Estados Unidos
2023 Prémio de Inovação J. Norberto Pires
Universidade de Coimbra, Portugal
2022 Paper published in Top 5% area of Geriatrics & Gerontology
2021 Best ePoster of the 33rd National Meeting of Epileptology
Portuguese League Against Epilepsy (LPCE), Portugal
2011 Lusitanian Pharmaceutical Society Award
Order of Pharmacists (Portugal), Portugal
2010 3% Best Students Award - 2010 / 2011
University of Coimbra, Portugal
2009 3% Best Students Award - 2009 / 2010
University of Coimbra, Portugal
2008 3% Best Students Award - 2008 / 2009
University of Coimbra, Portugal
2007 3% Best Students Award - 2007 / 2008
University of Coimbra, Portugal
2005 Calazans Award of Academic Merit
Engenheiro Acácio Calazans Duarte Secondary School, Portugal
2004 Calazans Award of Academic Merit
Engenheiro Acácio Calazans Duarte Secondary School, Portugal

Outra distinção

2012 PhD scholarship (SFRH/BD/78256/2011)
Foundation for Science and Technology (FCT), Portugal
2009 Integration into Research Grant (BII)
Foundation for Science and Technology (FCT), Portugal