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Ricardo Henriques' academic trajectory originated in particle physics, with his research focus transitioning to biological physics during doctoral studies conducted across four international institutions: Instituto de Medicina Molecular João Lobo Antunes (Portugal), Institut Pasteur (France), Council for Scientific and Industrial Research (South Africa), and Andor Technology (UK/USA). Under the mentorship of Musa Mhlanga and Christophe Zimmer, he pioneered real-time super-resolution fluorescence microscopy techniques, laying the foundation for subsequent technological developments that bridge optical physics and cell biology. The computational frameworks he created during this period, including QuickPALM (the first open-source software for single-molecule localisation microscopy) and subsequent tools like NanoJ, SRRF, and SQUIRREL, established new standards for quantitative nanoscale imaging. These innovations enabled his early applications in decoding spatial-temporal dynamics of viral entry mechanisms and immune cell receptor organisation, significantly advancing understanding of host-pathogen interactions. Following postdoctoral research at Institut Pasteur (2011-2013), Henriques established his independent group at University College London in 2013 with dual objectives: developing accessible imaging technologies and investigating fundamental cell biological processes. This dual approach intensified through strategic expansions to the Francis Crick Institute (2017) and subsequent leadership roles, culminating in his promotion to Full Professor at UCL in 2019. Since 2020, his laboratory has operated from Portuguese research institutions, first at Instituto Gulbenkian de Ciência, then permanently at ITQB NOVA from 2024, while maintaining active collaborations across multiple international labs. His commitment to open science manifests through continuous development of community-driven tools like ZeroCostDL4Mic and DL4MicEverywhere, which democratise AI-powered image analysis by eliminating computational barriers. The recent integration of eSRRF into Python via NanoPyx exemplifies ongoing efforts by his team to enhance accessibility while maintaining rigorous performance standards for live-cell 3D super-resolution imaging. Current research directions in his group focus on adaptive microscopy systems guided by machine learning, particularly through ERC-funded projects investigating AI-driven 4D super-resolution imaging of viral replication dynamics. An updated record of publications, software resources, and research activities remains available through the Henriques Laboratory website (https://henriqueslab.org), reflecting the transparency and reproducibility principles central to his research.
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Identificação

Identificação pessoal

Nome completo
Ricardo José dos Santos Duarte Vieira Henriques

Nomes de citação

  • Henriques, Ricardo

Identificadores de autor

Ciência ID
1318-A3CF-7610
ORCID iD
0000-0002-2043-5234
Google Scholar ID
-peQ4ZsAAAAJ

Endereços de correio eletrónico

  • r.henriques@ucl.ac.uk (Profissional)
  • r.henriques@itqb.unl.pt (Pessoal)

Telefones

Telemóvel
  • (+351) 934420536 (Profissional)

Moradas

  • Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA), Av. da República, 2780-157, Oeiras, Oeiras, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2008/09/01 - 2011/09/01
Concluído
 Structural Biology and Biophysics (Doutoramento)
Instituto de Medicina Molecular, Portugal
"Beyond Rayleigh's limit: achieving real-time super-resolution fluorescence microscopy" (TESE/DISSERTAÇÃO)
 Honra e Louvor
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/10/01 - Atual Investigador principal (carreira) (Investigação) Universidade Nova de Lisboa, Portugal
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2020/09/01 - 2024/09/30 Investigador principal (carreira) (Investigação) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/09/01 - 2025/08/31 Professor Visitante (Docente Universitário) MRC Laboratory for Molecular Cell Biology, Reino Unido
University College London Division of Biosciences, Reino Unido
2019/10/01 - 2020/08/31 Professor Catedrático (Docente Universitário) University College London, Reino Unido
University College London, Reino Unido
(...)
2013/09/01 - 2019/10/01 Professor Associado (Docente Universitário) University College London, Reino Unido
Projetos

Bolsa

Designação Financiadores
2020/07 - 2028/09 Optical Biology
218530/Z/19/Z
 Wellcome Trust
2021/07 - 2026/06 Enabling Live-Cell 4D Super-Resolution Microscopy Guided by Artificial Intelligence
101001332
 European Research Council
2022/01 - 2025/01 Regulation of de Novo Centriole Biogenesis by the Actin Network
Provided by PTCRIS: PTDC/BIA-CEL/4202/2021
 Fundação para a Ciência e a Tecnologia
2021/03 - 2024/02 Investigação dos mecanismos subjacentes à interacção da imunidade autónoma com a divisão e persistência intracelular de Staphylococcus aureus.
Provided by PTCRIS: PTDC/BIA-MIC/2422/2020
 Fundação para a Ciência e a Tecnologia
2018/09 - 2022/09 Content Aware AI Driven Driven Super Resolution Microscopy
BB/S507532/1
 Biotechnology and Biological Sciences Research Council
2020/06 - 2021/06 Benchtop, turnkey super-resolution microscopy for biology, biophysics and biotechnology
BB/T01749X/1
 Biotechnology and Biological Sciences Research Council
2019/01 - 2020/02 Democratising Live-Cell Adaptive Super-Resolution Microscopy based on SRRF
BB/R021805/1
 Biotechnology and Biological Sciences Research Council
2013/07 - 2016/12 Imagiologia da estrutura e dinâmica de moléculas e complexos em organismos vivos
Provided by PTCRIS: RECI/BEX-BCM/0083/2012
 Fundação para a Ciência e a Tecnologia
2008/01 - 2011/12 Identificação e caracterização dos supercomplexos das cadeias respiratórias aeróbias das bactérias Escherichia coli e Bacillus subtilis
Provided by PTCRIS: PTDC/SAU-GMG/115652/2009
 Fundação para a Ciência e a Tecnologia
2008/01 - 2011/12 Identificação e caracterização dos supercomplexos das cadeias respiratórias aeróbias das bactérias Escherichia coli e Bacillus subtilis
Provided by PTCRIS: PTDC/BIA-PRO/67105/2006
 Fundação para a Ciência e a Tecnologia
2010/01 - 2011/10 SPATIO-TEMPORAL TRACKING OF GENE EXPRESSION IN LIVING CELLS VIA SUPER-RESOLUTION MICROSCOPY
Provided by PTCRIS: SFRH/BD/63680/2009
 Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2016/12 - 2021/12 Understanding cellular organisation: from archaea to eukaryotes
203276/Z/16/Z
Investigador
Wellcome Trust
Em curso
2017/12 - 2018/12 An accessible framework to achieve multi-dimensional live-cell super-resolution high-content screening
BB/P027431/1
Investigador responsável
Biotechnology and Biological Sciences Research Council
Concluído
2016/01 - 2018/12 Super-Beacons and Beacon-STORM: a new generation of small tunable photoswitching probes and Super-Resolution approaches.
BB/M022374/1
Investigador responsável
Biotechnology and Biological Sciences Research Council
Concluído
2017/05 - 2018/05 Enabling Live-Cell Super Resolution Imaging Through Lattice Light Sheet Microscopy
BB/R000697/1
Investigador
Biotechnology and Biological Sciences Research Council
Concluído
2013/07 - 2016/06 Imaging the structure and dynamics of molecules and complexes in living organisms
Provided by PTCRIS: 124825
Investigador
Instituto Gulbenkian de Ciência
2011/01 - 2014/06 Super-resolution Imaging of Gene Expression & Nuclear Architecture
Provided by PTCRIS: 115652
Investigador
Instituto de Medicina Molecular
2008/01 - 2011/12 Identification and characterization of the supercomplexes from the bacterial aerobic respiratory chain of Escherichia coli and Bacillus subtilis
Provided by PTCRIS: 67105
Desenvolvimento técnico
Instituto de Medicina Molecular
Concluído
2007/07 - 2010/07 Effects of inflammation on bone and cartilage: collagen pattern and biomechanical properties
Provided by PTCRIS: 65992
Desenvolvimento técnico
Instituto de Medicina Molecular
Concluído
Produções

Publicações

Artigo em revista
  1. Bruno M. Saraiva; Inês Cunha; António D. Brito; Gautier Follain; Raquel Portela; Robert Haase; Pedro M. Pereira; Guillaume Jacquemet; Ricardo Henriques. "Efficiently accelerated bioimage analysis with NanoPyx, a Liquid Engine-powered Python framework". Nature Methods (2025): https://doi.org/10.1038/s41592-024-02562-6.
    10.1038/s41592-024-02562-6
  2. Leonor Morgado; Estibaliz Gómez-de-Mariscal; Hannah S. Heil; Ricardo Henriques. "The rise of data-driven microscopy powered by machine learning". Journal of Microscopy (2024): https://doi.org/10.1111/jmi.13282.
    10.1111/jmi.13282
  3. Hidalgo-Cenalmor I; Pylvänäinen JW; G Ferreira M; Russell CT; Saguy A; Arganda-Carreras I; Shechtman Y; AI4Life Horizon Europe Program Consortium; Gómez-de-Mariscal E. "DL4MicEverywhere: deep learning for microscopy made flexible, shareable and reproducible.". Nature methods (2024): http://europepmc.org/abstract/med/38760611.
    10.1038/s41592-024-02295-6
  4. Simon Schäper; António D. Brito; Bruno M. Saraiva; Georgia R. Squyres; Matthew J. Holmes; Ethan C. Garner; Zach Hensel; Ricardo Henriques; Mariana G. Pinho. "Cell constriction requires processive septal peptidoglycan synthase movement independent of FtsZ treadmilling in Staphylococcus aureus". Nature Microbiology (2024): https://doi.org/10.1038/s41564-024-01629-6.
    10.1038/s41564-024-01629-6
  5. Estibaliz Gómez-de-Mariscal; Mario Del Rosario; Joanna W. Pylvänäinen; Guillaume Jacquemet; Ricardo Henriques. "Harnessing artificial intelligence to reduce phototoxicity in live imaging". Journal of Cell Science (2024): https://doi.org/10.1242/jcs.261545.
    10.1242/jcs.261545
  6. Ricardo Henriques; Christophe Leterrier; Aubrey Weigel. "Decoding life's inner workings: advances in quantitative bioimaging". Open Biology (2023): https://doi.org/10.1098/rsob.230329.
    10.1098/rsob.230329
  7. Pylvänäinen JW; Laine RF; Saraiva BMS; Ghimire S; Follain G; Henriques R; Jacquemet G. "Fast4DReg - fast registration of 4D microscopy datasets.". Journal of cell science (2023): http://europepmc.org/abstract/med/36727532.
    10.1242/jcs.260728
  8. Aristova D; Selin R; Heil HS; Kosach V; Slominsky Y; Yarmoluk S; Pekhnyo V; et al. "Trimethine Cyanine Dyes as NA-Sensitive Probes for Visualization of Cell Compartments in Fluorescence Microscopy.". ACS omega (2022): http://europepmc.org/abstract/med/36591208.
    10.1021/acsomega.2c05231
  9. Etienne Boulter; Julien Colombelli; Ricardo Henriques; Chloé C. Féral. "The LEGO® brick road to open science and biotechnology". Trends in Biotechnology (2022): https://doi.org/10.1016/j.tibtech.2022.02.003.
    10.1016/j.tibtech.2022.02.003
  10. Spahn C; Gómez-de-Mariscal E; Laine RF; Pereira PM; von Chamier L; Conduit M; Pinho MG; et al. "DeepBacs for multi-task bacterial image analysis using open-source deep learning approaches.". Communications biology (2022): http://europepmc.org/abstract/med/35810255.
    10.1038/s42003-022-03634-z
  11. Afonso Mendes; Hannah S. Heil; Simao Coelho; Christophe Leterrier; Ricardo Henriques. "Mapping molecular complexes with super-resolution microscopy and single-particle analysis". Open Biology (2022): https://doi.org/10.1098/rsob.220079.
    10.1098/rsob.220079
  12. Tomaz D; Pereira PM; Guerra N; Dyson J; Gould K; Henriques R. "Nanoscale Colocalization of NK Cell Activating and Inhibitory Receptors Controls Signal Integration.". Frontiers in immunology (2022): http://europepmc.org/abstract/med/35720315.
    10.3389/fimmu.2022.868496
  13. Korovesi AG; Morgado L; Fumasoni M; Henriques R; Heil HS; Del Rosario M. "Expansion Microscopy on Saccharomyces cerevisiae.". microPublication biology (2022): http://europepmc.org/abstract/med/35647499.
    10.17912/micropub.biology.000566
  14. Lena Harker-Kirschneck; Anne E. Hafner; Tina Yao; Christian Vanhille-Campos; Xiuyun Jiang; Andre Pulschen; Fredrik Hurtig; et al. "Physical mechanisms of ESCRT-III–driven cell division". Proceedings of the National Academy of Sciences (2022): https://doi.org/10.1073/pnas.2107763119.
    10.1073/pnas.2107763119
  15. Kevin D. Whitley; Calum Jukes; Nicholas Tregidgo; Eleni Karinou; Pedro Almada; Yann Cesbron; Ricardo Henriques; Cees Dekker; Séamus Holden. "FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in Bacillus subtilis cell division". Nature Communications (2021): https://doi.org/10.1038/s41467-021-22526-0.
    10.1038/s41467-021-22526-0
  16. Mario Del Rosario; Hannah S. Heil; Afonso Mendes; Vittorio Saggiomo; Ricardo Henriques. "The Field Guide to 3D Printing in Optical Microscopy for Life Sciences". Advanced Biology (2021): https://doi.org/10.1002/adbi.202100994.
    10.1002/adbi.202100994
  17. Laine RF; Arganda-Carreras I; Henriques R; Jacquemet G. "Avoiding a replication crisis in deep-learning-based bioimage analysis.". Nature methods (2021): http://europepmc.org/abstract/med/34608322.
    10.1038/s41592-021-01284-3
  18. Bruno M. Saraiva; Ludwig Krippahl; Sérgio R. Filipe; Ricardo Henriques; Mariana G. Pinho. "eHooke: A tool for automated image analysis of spherical bacteria based on cell cycle progression". Biological Imaging (2021): 1-25. https://doi.org/10.1017/S2633903X21000027.
    10.1017/S2633903X21000027
  19. von Chamier L; Laine RF; Jukkala J; Spahn C; Krentzel D; Nehme E; Lerche M; et al. "Democratising deep learning for microscopy with ZeroCostDL4Mic.". Nature communications (2021): http://europepmc.org/abstract/med/33859193.
    10.1038/s41467-021-22518-0
  20. Emma Touizer; Christian Sieben; Ricardo Henriques; Mark Marsh; Romain F. Laine. "Application of Super-Resolution and Advanced Quantitative Microscopy to the Spatio-Temporal Analysis of Influenza Virus Replication". Viruses (2021): https://doi.org/10.3390/v13020233.
    10.3390/v13020233
  21. Yue Yuan; Caron A. Jacobs; Isabel Llorente Garcia; Pedro M. Pereira; Scott P. Lawrence; Romain F. Laine; Mark Marsh; Ricardo Henriques. "Single-Molecule Super-Resolution Imaging of T-Cell Plasma Membrane CD4 Redistribution upon HIV-1 Binding". Viruses 13 1 (2021): 142-142. https://doi.org/10.3390/v13010142.
    10.3390/v13010142
  22. Spark A; Kitching A; Esteban-Ferrer D; Handa A; Carr AR; Needham LM; Ponjavic A; et al. "vLUME: 3D virtual reality for single-molecule localization microscopy.". Nature methods (2020): http://europepmc.org/abstract/med/33046895.
    10.1038/s41592-020-0962-1
  23. Henriques, Ricardo. "Closed mitosis requires local disassembly of the nuclear envelope". Nature 585 7823 (2020): 119-123.
    10.1038/s41586-020-2648-3
  24. Tarrason Risa G; Hurtig F; Bray S; Hafner AE; Harker-Kirschneck L; Faull P; Davis C; et al. "The proteasome controls ESCRT-III-mediated cell division in an archaeon.". Science (New York, N.Y.) (2020): http://europepmc.org/abstract/med/32764038.
    10.1126/science.aaz2532
  25. Guillaume Jacquemet; Alexandre F. Carisey; Hellyeh Hamidi; Ricardo Henriques; Christophe Leterrier. "The cell biologist's guide to super-resolution microscopy". Journal of Cell Science (2020): https://doi.org/10.1242/jcs.240713.
    10.1242/jcs.240713
  26. Pulschen AA; Mutavchiev DR; Culley S; Sebastian KN; Roubinet J; Roubinet M; Risa GT; et al. "Live Imaging of a Hyperthermophilic Archaeon Reveals Distinct Roles for Two ESCRT-III Homologs in Ensuring a Robust and Symmetric Division.". Current biology : CB (2020): http://europepmc.org/abstract/med/32502411.
    10.1016/j.cub.2020.05.021
  27. Stubb A; Laine RF; Miihkinen M; Hamidi H; Guzmán C; Henriques R; Jacquemet G; Ivaska J. "Fluctuation-Based Super-Resolution Traction Force Microscopy.". Nano letters (2020): http://europepmc.org/abstract/med/32142297.
    10.1021/acs.nanolett.9b04083
  28. Christopher Bricogne; Michael Fine; Pedro M. Pereira; Julia Sung; Maha Tijani; Youxue Wang; Ricardo Henriques; Mary K. Collins; Donald W. Hilgemann. "TMEM16F activation by Ca2+ triggers plasma membrane expansion and directs PD-1 trafficking". Scientific Reports 9 1 (2019): https://doi.org/10.1038/s41598-018-37056-x.
    10.1038/s41598-019-43808-0
  29. Thevathasan JV; Kahnwald M; Cieslinski K; Hoess P; Peneti SK; Reitberger M; Heid D; et al. "Publisher Correction: Nuclear pores as versatile reference standards for quantitative superresolution microscopy.". Nature methods (2019): http://europepmc.org/abstract/med/31653976.
    10.1038/s41592-019-0659-5
  30. Robert D. M. Gray; David Albrecht; Corina Beerli; Moona Huttunen; Gary H. Cohen; Ian J. White; Jemima J. Burden; Ricardo Henriques; Jason Mercer. "Nanoscale polarization of the entry fusion complex of vaccinia virus drives efficient fusion". Nature Microbiology 4 10 (2019): 1636-1644. https://doi.org/10.1038/s41564-019-0488-4.
    10.1038/s41564-019-0488-4
  31. Henriques, Ricardo. "Nuclear pores as versatile reference standards for quantitative superresolution microscopy". Nature Methods (2019): http://dx.doi.org/10.1038/s41592-019-0574-9.
    10.1038/s41592-019-0574-9
  32. Patel L; Gustafsson N; Lin Y; Ober R; Henriques R; Cohen E. "A HIDDEN MARKOV MODEL APPROACH TO CHARACTERIZING THE PHOTO-SWITCHING BEHAVIOR OF FLUOROPHORES.". The annals of applied statistics (2019): http://europepmc.org/abstract/med/31933716.
    10.1214/19-aoas1240
  33. Sage D; Pham TA; Babcock H; Lukes T; Pengo T; Chao J; Velmurugan R; et al. "Publisher Correction: Super-resolution fight club: assessment of 2D and 3D single-molecule localization microscopy software.". Nature methods (2019): http://europepmc.org/abstract/med/31097821.
    10.1038/s41592-019-0453-4
  34. Sage D; Pham TA; Babcock H; Lukes T; Pengo T; Chao J; Velmurugan R; et al. "Super-resolution fight club: assessment of 2D and 3D single-molecule localization microscopy software.". Nature methods (2019): http://europepmc.org/abstract/med/30962624.
    10.1038/s41592-019-0364-4
  35. Pereira PM; Albrecht D; Culley S; Jacobs C; Marsh M; Mercer J; Henriques R. "Fix Your Membrane Receptor Imaging: Actin Cytoskeleton and CD4 Membrane Organization Disruption by Chemical Fixation.". Frontiers in immunology (2019): http://europepmc.org/abstract/med/31024536.
    10.3389/fimmu.2019.00675
  36. Felix Weihs; Katarzyna Wacnik; Robert D. Turner; Siân Culley; Ricardo Henriques; Simon J. Foster. "Heterogeneous localisation of membrane proteins in Staphylococcus aureus". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-21750-x.
    10.1038/s41598-018-21750-x
  37. Krokowski, Sina; Lobato-Márquez, Damián; Chastanet, Arnaud; Pereira, Pedro Matos; Angelis, Dimitrios; Galea, Dieter; Larrouy-Maumus, Gerald; et al. "Septins Recognize and Entrap Dividing Bacterial Cells for Delivery to Lysosomes". Cell Host & Microbe 24 6 (2018): 866-874.e4. http://dx.doi.org/10.1016/j.chom.2018.11.005.
    10.1016/j.chom.2018.11.005
  38. Weigert M; Schmidt U; Boothe T; Müller A; Dibrov A; Jain A; Wilhelm B; et al. "Content-aware image restoration: pushing the limits of fluorescence microscopy.". Nature methods (2018): http://europepmc.org/abstract/med/30478326.
    10.1038/s41592-018-0216-7
  39. Siân Culley; Kalina L. Tosheva; Pedro Matos Pereira; Ricardo Henriques. "SRRF: Universal live-cell super-resolution microscopy". The International Journal of Biochemistry & Cell Biology 101 (2018): 74-79. https://doi.org/10.1016/j.biocel.2018.05.014.
    10.1016/j.biocel.2018.05.014
  40. Siân Culley; David Albrecht; Caron Jacobs; Pedro Matos Pereira; Christophe Leterrier; Jason Mercer; Ricardo Henriques. "Quantitative mapping and minimization of super-resolution optical imaging artifacts". Nature Methods (2018): https://doi.org/10.1038/nmeth.4605.
    10.1101/158279
  41. Dix CL; Matthews HK; Uroz M; McLaren S; Wolf L; Heatley N; Win Z; et al. "The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division.". Developmental cell (2018): http://europepmc.org/abstract/med/29634933.
    10.1016/j.devcel.2018.03.009
  42. Robert D. M. Gray; Jason Mercer; Ricardo Henriques. "Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper". Journal of Visualized Experiments 122 (2017): https://doi.org/10.3791%2F55471.
    10.3791/55471
  43. Nils Gustafsson; Siân Culley; George Ashdown; Dylan M. Owen; Pedro Matos Pereira; Ricardo Henriques. "Fast live-cell conventional fluorophore nanoscopy with ImageJ through super-resolution radial fluctuations". Nature Communications 7 (2016): 12471-12471. https://doi.org/10.1038/ncomms12471.
    10.1038/ncomms12471
  44. Barbara Clough; Eric Y Denkers; Joseph D. Wright; Pedro M. Pereira; Elizabeth M. Hirst; Ashleigh C. Johnston; Ricardo Henriques; Eva-Maria Frickel. "K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFN¿-Stimulated Human Cells". PLOS Pathogens 12 11 (2016): e1006027-e1006027. http://dx.doi.org/10.1371/journal.ppat.1006027.
    10.1371/journal.ppat.1006027
  45. Joana G. Silva; Nuno P. Martins; Ricardo Henriques; Helena Soares. "HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse". The Journal of Immunology 197 10 (2016): 4042-4052. https://doi.org/10.4049/jimmunol.1601132.
    10.4049/jimmunol.1601132
  46. Siân Culley; Greg Towers; David Selwood; Ricardo Henriques; Joe Grove. "Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy". Viruses 8 12 (2016): 201-201. https://doi.org/10.3390/v8070201.
    10.3390/v8070201
  47. Gray RD; Beerli C; Pereira PM; Scherer KM; Samolej J; Bleck CK; Mercer J; Henriques R. "VirusMapper: open-source nanoscale mapping of viral architecture through super-resolution microscopy.". (2016): http://europepmc.org/abstract/med/27374400.
    10.1038/srep29132
  48. Sirianni A; Krokowski S; Lobato-Márquez D; Buranyi S; Pfanzelter J; Galea D; Willis A; et al. "Mitochondria mediate septin cage assembly to promote autophagy of Shigella.". (2016): http://europepmc.org/abstract/med/27259462.
  49. Scholefield J; Henriques R; Savulescu AF; Fontan E; Boucharlat A; Laplantine E; Smahi A; et al. "Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti.". (2016): http://europepmc.org/abstract/med/27586688.
    10.1038/ncomms12629
  50. Almada P; Culley S; Henriques R. "PALM and STORM: Into large fields and high-throughput microscopy with sCMOS detectors.". (2015): http://europepmc.org/abstract/med/26079924.
    10.1016/j.ymeth.2015.06.004
  51. Pereira PM; Almada P; Henriques R. "High-content 3D multicolor super-resolution localization microscopy.". (2015): http://europepmc.org/abstract/med/25640426.
    10.1016/bs.mcb.2014.10.004
  52. Tarantino N; Tinevez JY; Crowell EF; Boisson B; Henriques R; Mhlanga M; Agou F; Israël A; Laplantine E. "TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures.". (2014): http://europepmc.org/abstract/med/24446482.
    10.1083/jcb.201307172
  53. Soares H; Henriques R; Sachse M; Ventimiglia L; Alonso MA; Zimmer C; Thoulouze MI; Alcover A. "Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse.". (2013): http://europepmc.org/abstract/med/24101378.
    10.1084/jem.20130150
  54. Ehsani S; Santos JC; Rodrigues CD; Henriques R; Audry L; Zimmer C; Sansonetti P; Tran Van Nhieu G; Enninga J. "Hierarchies of host factor dynamics at the entry site of Shigella flexneri during host cell invasion.". (2012): http://europepmc.org/abstract/med/22526677.
    10.1128/IAI.06391-11
  55. Lelek M; Di Nunzio F; Henriques R; Charneau P; Arhel N; Zimmer C. "Superresolution imaging of HIV in infected cells with FlAsH-PALM.". (2012): http://europepmc.org/abstract/med/22586087.
    10.1073/pnas.1013267109
  56. Herbert S; Henriques R. "Enhanced epifluorescence microscopy by uniform and intensity optimized illumination.". (2012): http://europepmc.org/abstract/med/22392634.
    10.1002/cyto.a.21177
  57. Gomes-Santos CS; Itoe MA; Afonso C; Henriques R; Gardner R; Sepúlveda N; Simões PD; et al. "Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.". (2012): http://europepmc.org/abstract/med/22238609.
    10.1371/journal.pone.0029408
  58. Henriques, Ricardo. "Single-molecule localization super-resolution microscopy: deeper and faster". Microscopy and microanalysis 18 6 (2012): 1419-1429.
    10.1017/s1431927612013347
  59. Henriques R; Griffiths C; Hesper Rego E; Mhlanga MM. "PALM and STORM: unlocking live-cell super-resolution.". (2011): http://europepmc.org/abstract/med/21254001.
    10.1002/bip.21586
  60. Henriques R; Lelek M; Fornasiero EF; Valtorta F; Zimmer C; Mhlanga MM. "QuickPALM: 3D real-time photoactivation nanoscopy image processing in ImageJ.". (2010): http://europepmc.org/abstract/med/20431545.
    10.1038/nmeth0510-339
  61. Henriques R; Mhlanga MM. "PALM and STORM: what hides beyond the Rayleigh limit?". (2009): http://europepmc.org/abstract/med/19548237.
    10.1002/biot.200900024
  62. Henriques, Ricardo. "Editorial: Imaging host-pathogen interactions". Biotechnology Journal (2009): http://dx.doi.org/10.1002/biot.200900129.
    10.1002/biot.200900129
  63. Henriques, Ricardo. "Chronic arthritis directly induces quantitative and qualitative bone disturbances leading to compromised biomechanical properties.". Clinical and experimental rheumatology (2009):
  64. Rino J; Braga J; Henriques R; Carmo-Fonseca M. "Frontiers in fluorescence microscopy.". (2009): http://europepmc.org/abstract/med/19247949.
    10.1387/ijdb.072351jr
  65. Barreiro LB; Henriques R; Mhlanga MM. "High-throughput SNP genotyping: combining tag SNPs and molecular beacons.". (2009): http://europepmc.org/abstract/med/19768600.
    10.1007/978-1-60327-411-1_17
Livro
  1. Ann Wheeler; Ricardo Henriques. Standard and Super-Resolution Bioimaging Data Analysis. John Wiley {\&. 2017.
    10.1002/9781119096948
Poster em conferência
  1. Del Rosario, Mario; Heil, Hannah; Leandro Lemgruber; Henriques, Ricardo. "Atlas Parasitus: Building A 3d Toxoplasma Gondii Cellular Components Map To Study Organelle Reorganisation During Cell Division.". Trabalho apresentado em Focus on Microscopy 2022, 2022.
Pré-impressão
  1. Ricardo Henriques; Afonso Mendes; Bruno Saraiva; Guillaume Jacquemet; João Mamede; Christophe Leterrier. "Structural Repetition Detector: multi-scale quantitative mapping of molecular complexes through microscopy". 2024. https://doi.org/10.21203/rs.3.rs-5182329/v1.
    10.21203/rs.3.rs-5182329/v1
  2. Mario Del Rosario; Estibaliz Gómez-de-Mariscal; Leonor Morgado; Raquel Portela; Guillaume Jacquemet; Pedro M. Pereira; Ricardo Henriques. "PhotoFiTT: A Quantitative Framework for Assessing Phototoxicity in Live-Cell Microscopy Experiments". 2024. https://doi.org/10.1101/2024.07.16.603046.
    10.1101/2024.07.16.603046
  3. Afonso Mendes; Bruno M. Saraiva; Guillaume Jacquemet; João I. Mamede; Christophe Leterrier; Ricardo Henriques. "Structural Repetition Detector: multi-scale quantitative mapping of molecular complexes through microscopy". 2024. https://doi.org/10.1101/2024.09.16.613204.
    10.1101/2024.09.16.613204
  4. Ricardo Henriques; Mario del Rosario; Estibaliz Gómez-de-Mariscal; Leonor Morgado; Raquel Portela; Guillaume Jacquemet; Pedro Pereira. "PhotoFiTT: A Quantitative Framework for Assessing Phototoxicity in Live-Cell Microscopy Experiments". 2024. https://doi.org/10.21203/rs.3.rs-4809905/v1.
    10.21203/rs.3.rs-4809905/v1
  5. Iván Hidalgo-Cenalmor; Joanna W Pylvänäinen; Mariana G Ferreira; Craig T Russell; Ignacio Arganda-Carreras; Guillaume Jacquemet; Ricardo Henriques; Estibaliz Gómez-de-Mariscal. "DL4MicEverywhere: Deep learning for microscopy made flexible, shareable, and reproducible". 2023. https://doi.org/10.1101/2023.11.19.567606.
    10.1101/2023.11.19.567606
  6. Christoph Spahn; Stuart Middlemiss; Estibaliz Gómez-de-Mariscal; Ricardo Henriques; Helge B. Bode; Séamus Holden; Mike Heilemann. "Transertion and cell geometry organize theEscherichia colinucleoid during rapid growth". 2023. https://doi.org/10.1101/2023.10.16.562172.
    10.1101/2023.10.16.562172
  7. Bruno M. Saraiva; Inês M. Cunha; António D. Brito; Gautier Follain; Raquel Portela; Robert Haase; Pedro M. Pereira; Guillaume Jacquemet; Ricardo Henriques. "NanoPyx: super-fast bioimage analysis powered by adaptive machine learning". 2023. https://doi.org/10.1101/2023.08.13.553080.
    10.1101/2023.08.13.553080
  8. Daniel Krentzel; Matouš Elphick; Marie-Charlotte Domart; Christopher J. Peddie; Romain F. Laine; Ricardo Henriques; Lucy M. Collinson; Martin L. Jones. "CLEM-Reg: An automated point cloud based registration algorithm for correlative light and volume electron microscopy". 2023. https://doi.org/10.1101/2023.05.11.540445.
    10.1101/2023.05.11.540445
  9. Pylvänäinen JW; Laine RF; Saraiva BM; Ghimire S; Follain G; Henriques R; Jacquemet G. "Fast4DReg: Fast registration of 4D microscopy datasets". 2022. http://europepmc.org/abstract/PPR/PPR534863.
    10.1101/2022.08.22.504744
  10. Korovesi AG; Morgado L; Fumasoni M; Henriques R; Heil H; Del Rosario M. "Expansion Microscopy on Saccharomyces cerevisiae". 2022. http://europepmc.org/abstract/PPR/PPR466677.
    10.20944/preprints202203.0146.v1
  11. Ouyang W; Beuttenmueller F; Gómez-de-Mariscal E; Pape C; Burke T; Garcia-López-de-Haro C; Russell C; et al. "BioImage Model Zoo: A Community-Driven Resource for Accessible Deep Learning in BioImage Analysis". 2022. http://europepmc.org/abstract/PPR/PPR504634.
    10.1101/2022.06.07.495102
  12. Laine RF; Heil HS; Coelho S; Nixon-Abell J; Jimenez A; Galgani T; Stubb A; et al. "High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation". 2022. http://europepmc.org/abstract/PPR/PPR479048.
    10.1101/2022.04.07.487490
  13. Spahn C; Laine RF; Pereira PM; Gómez-de-Mariscal E; von Chamier L; Conduit M; de Pinho MG; et al. "DeepBacs: Bacterial image analysis using open-source deep learning approaches". 2021. http://europepmc.org/abstract/PPR/PPR415602.
    10.1101/2021.11.03.467152
  14. Thevathasan JV; Kahnwald M; Cieslinski K; Hoess P; Peneti SK; Reitberger M; Heid D; et al. "Nuclear pores as versatile reference standards for quantitative superresolution microscopy". 2019. http://europepmc.org/abstract/PPR/PPR73672.
    10.1101/582668
Resumo em conferência
  1. Gómez-de-Mariscal, Estibaliz; Carlos García-López-de-Haro; Cristina de-la-Torre-Gutiérrez; Romain F. Laine; Guillaume Jacquemet; Henriques, Ricardo; Daniel Sage; Arrate Muñoz-Barrutia. "Reproducible user-friendly deep learning workflows for microscopy image analysis with deepImageJ". Trabalho apresentado em Focus on Microscopy, 2022.

Outros

Outra produção
  1. The Field Guide to 3D Printing in Microscopy. 2021. Mario Del Rosario; Hannah S. Heil; Afonso Mendes; Vittorio Saggiomo; Ricardo Henriques. https://doi.org/10.20944/preprints202105.0352.v1.
    10.20944/preprints202105.0352.v1
  2. Physical mechanisms of ESCRT-III-driven cell division in archaea. 2021. L. Harker-Kirschneck; A. E. Hafner; T. Yao; A. Pulschen; F. Hurtig; C. Vanhille-Campos; D. Hryniuk; et al. https://doi.org/10.1101/2021.03.23.436559.
    10.1101/2021.03.23.436559
  3. Single-molecule super-resolution imaging of T-cell plasma membrane CD4 redistribution upon HIV-1 binding. 2021. Yue Yuan; Caron Jacobs; Isabel Llorente Garcia; Pedro M. Pereira; Scott P. Lawrence; Romain F. Laine; Mark Marsh; Ricardo Henriques. https://doi.org/10.1101/2021.01.05.425371.
    10.1101/2021.01.05.425371
  4. FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division. 2020. Kevin D. Whitley; Calum Jukes; Nicholas Tregidgo; Eleni Karinou; Pedro Almada; Ricardo Henriques; Cees Dekker; Séamus Holden. https://doi.org/10.1101/2020.07.01.182006.
    10.1101/2020.07.01.182006
  5. ZeroCostDL4Mic: an open platform to use Deep-Learning in Microscopy. 2020. Henriques, Ricardo. http://dx.doi.org/10.1101/2020.03.20.000133.
    10.1101/2020.03.20.000133
  6. Live cell imaging of the hyperthermophilic archaeon Sulfolobus acidocaldarius identifies complementary roles for two ESCRTIII homologues in ensuring a robust and symmetric cell division. 2020. Pulschen AA; Mutavchiev DR; Sebastian KN; Roubinet J; Roubinet M; Risa GT; van Wolferen M; et al. http://europepmc.org/abstract/PPR/PPR113606.
    10.1101/2020.02.18.953042
  7. Super-Beacons: open-source probes with spontaneous tuneable blinking compatible with live-cell super-resolution microscopy. 2020. Pedro M. Pereira; Nils Gustafsson; Mark Marsh; Musa M. Mhlanga; Ricardo Henriques. https://doi.org/10.1101/2020.01.20.912311.
    10.1101/2020.01.20.912311
  8. vLUME: 3D Virtual Reality for Single-molecule Localization Microscopy. 2020. Spark A; Kitching A; Esteban-Ferrer D; Handa A; Carr AR; Needham L; Ponjavic A; et al. http://europepmc.org/abstract/PPR/PPR109626.
    10.1101/2020.01.20.912733
  9. Closed mitosis requires local disassembly of the nuclear envelope. 2019. Gautam Dey; Siân Culley; Scott Curran; Ricardo Henriques; Wanda Kukulski; Buzz Baum. https://doi.org/10.1101/779769.
    10.1101/779769
  10. Fluctuation-Based Super-Resolution Traction Force Microscopy. 2019. Stubb A; Laine RF; Guzmán C; Henriques R; Jacquemet G; Ivaska J. http://europepmc.org/abstract/PPR/PPR92766.
    10.1101/772947
  11. Between Life and Death: Reducing Phototoxicity in Super-Resolution Microscopy. 2019. Henriques, Ricardo. http://dx.doi.org/10.20944/preprints201908.0319.v1.
    10.20944/preprints201908.0319.v1
  12. Artificial Intelligence for Microscopy: What You Should Know. 2019. Lucas von Chamier; Romain F. Laine; Ricardo Henriques. https://doi.org/10.20944%2Fpreprints201902.0004.v1.
    10.20944/preprints201902.0004.v1
  13. Fix your membrane receptor imaging: Actin cytoskeleton and CD4 membrane organization disruption by chemical fixation. 2018. Pedro M. Pereira; David Albrecht; Caron Jacobs; Mark Marsh; Jason Mercer; Ricardo Henriques. https://doi.org/10.1101/450635.
    10.1101/450635
  14. NanoJ: a high-performance open-source super-resolution microscopy toolbox. 2018. Romain Laine; Kalina Tosheva; Nils Gustafsson; Robert D. M. Gray; Pedro Almada; David Albrecht; Gabriel T. Risa; et al. https://doi.org/10.1101%2F432674.
    10.1088/1361-6463/ab0261
  15. Super-resolution fight club: A broad assessment of 2D & 3D single-molecule localization microscopy software. 2018. Sage D; Pham T; Babcock H; Lukes T; Pengo T; Chao J; Velmurugan R; et al. http://europepmc.org/abstract/PPR/PPR7580.
    10.1101/362517
  16. Automating multimodal microscopy with NanoJ-Fluidics. 2018. Pedro Almada; Pedro Pereira; Siân Culley; Ghislaine Caillol; Fanny Boroni-Rueda; Christina L. Dix; Romain F. Laine; et al. https://doi.org/10.1101%2F320416.
    10.1038/s41467-019-09231-9
  17. Nanoscale colocalization of NK cell activating and inhibitory receptors controls signal integration. 2018. David Tomaz; Pedro Matos Pereira; Nadia Guerra; Julian Dyson; Ricardo Henriques; Keith Gould. https://doi.org/10.1101%2F266429.
    10.1101/266429
  18. A hidden Markov model approach to characterizing the photo-switching behavior of fluorophores. 2017. Lekha Patel; Nils Gustafsson; Yu Lin; Raimund Ober; Ricardo Henriques; Edward Cohen. https://doi.org/10.1101%2F223875.
    10.1101/223875
  19. Content-Aware Image Restoration: Pushing the Limits of Fluorescence Microscopy. 2017. Martin Weigert; Uwe Schmidt; Tobias Boothe; Andreas Müller; Alexandr Dibrov; Akanksha Jain; Benjamin Wilhelm; et al. https://doi.org/10.1101%2F236463.
    10.1101/236463
Distinções

Título

2019 Promotion to Professor Chair of Computational and Optiocal Biophysics
University College London, Reino Unido

Outra distinção

2024 Elected EMBO member
European Molecular Biology Laboratory, Alemanha