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Identificação

Identificação pessoal

Nome completo
Andreas Krueger

Nomes de citação

  • Krueger, Andreas

Identificadores de autor

Ciência ID
161A-A1F4-70E5
ORCID iD
0000-0001-7873-7334

Telefones

Telefone
  • (+49) 641 99 Ext.: 34250 (Profissional)

Moradas

  • Schubertstr. 81, 35392, Gießen, Gießen, Alemanha (Profissional)

Websites

  • https://www.uni-giessen.de/de/fbz/fb08/Inst/immun (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Biologia do Desenvolvimento

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Alemão (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
1999/09/01 - 2002/07/01
Concluído
 Dr.rer.nat. (Doktor (PhD))
Especialização em Biochemistry, Immunology
University of Hannover, Alemanha
"Das zelluläre FLICE-inhibitorische Protein (c-FLIP): Mechanismen der Regulation CD95-vermittelter Apoptose in der T-Zell-Immunantwort" (TESE/DISSERTAÇÃO)
1994/10/01 - 1999/08/02
Concluído
 Biochemistry (Master)
Especialização em Biochemistry, Biophysical Chemistry, Immunology
University of Hannover, Alemanha
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/04/01 - Atual Investigador principal (carreira) (Investigação) Justus-Liebig-Universität Giessen Fachbereich 08 Biologie und Chemie, Alemanha
2015/11/01 - 2022/03/31 Investigador principal (carreira) (Investigação) Goethe-Universität Frankfurt am Main, Alemanha
Goethe-Universität Frankfurt am Main, Institute for Molecular Medicine, Alemanha
2007/07/01 - 2015/10/31 Investigador principal (carreira) (Investigação) Medizinische Hochschule Hannover, Alemanha
2003/04/01 - 2007/06/30 Pós-doutorado (Investigação) Harvard Medical School, Estados Unidos
Dana-Farber Cancer Institute, Estados Unidos
2002/07/01 - 2003/03/31 Pós-doutorado (Investigação) Deutsches Krebsforschungszentrum, Alemanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/04/01 - Atual Professor for Molecular immunology Justus-Liebig-Universität Giessen Fachbereich 08 Biologie und Chemie, Alemanha
2015/11/01 - 2022/03/31 Professor for Molecular Immunology Goethe-Universität Frankfurt am Main, Alemanha
Goethe-Universität Frankfurt am Main, Institute for Molecular Medicine, Alemanha
2014/11/01 - 2015/10/31 Professor for Regenerative Immunology Medizinische Hochschule Hannover, Alemanha
Projetos

Bolsa

Designação Financiadores
2024/07/01 - 2027/06/30 Deconstructing context-dependent regulatory miRNA networks in T-cell development
RTG2355/2
Investigador responsável
Deutsche Forschungsgemeinschaft
2020/01/01 - 2024/12/31 Thymic selection of MAIT cells
KR2320/7-1
Investigador responsável
Deutsche Forschungsgemeinschaft
Em curso
2019/07/01 - 2023/06/30 Identification of miRNA Targeting Hierarchies in Lymphocyte Development
CRC902-B15
Investigador responsável
Deutsche Forschungsgemeinschaft
2018/04/01 - 2022/12/31 Cell cycle dynamics in early T-cell development and their role in tissue homeostasis
KR2320/6-1
Investigador responsável
Deutsche Forschungsgemeinschaft
Em curso
2015/11/01 - 2019/11/01 microRNA in Treg-cell development and function – the role of miR-181
KR2320/5-1
Investigador responsável
Deutsche Forschungsgemeinschaft
Concluído
2011/07/01 - 2019/06/30 Molecular mechanisms of T-cell regeneration – microRNA gene regulatory networks
CRC902-B15
CRC738-A7
Investigador responsável
Deutsche Forschungsgemeinschaft
2013/11/01 - 2018/11/01 Mapping the thymic progenitor niche
KR2320/3-1
Investigador responsável
Deutsche Forschungsgemeinschaft
2008/03/01 - 2013/11/01 Commitment and efficiency of extrathymic T cell precursors - towards improved T lineage reconstitution after bone marrow transplantation
KR2320/2-1
Investigador responsável
Deutsche Forschungsgemeinschaft
Concluído
2003/04/01 - 2007/06/30 Signal transduction of the pre-TCR
KR2320/1-1
Investigador Pós-doutorado
Deutsche Forschungsgemeinschaft
Concluído
Produções

Publicações

Artigo em revista
  1. Frueh, Jochen T.; Campe, Julia; Sunaga-Franze, Daniele Yumi; Verheyden, Nikita A.; Ghimire, Sakhila; Meedt, Elisabeth; Haslinger, Denise; et al. "Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis". OncoImmunology 13 1 (2023): http://dx.doi.org/10.1080/2162402x.2023.2296712.
    10.1080/2162402x.2023.2296712
  2. Yang, Tao; Barros-Martins, Joana; Wang, Ziqing; Wencker, Melanie; Zhang, Jiang; Smout, Justine; Gambhir, Prerna; et al. "ROR¿t+ c-Maf+ V¿4+ ¿d T cells are generated in the adult thymus but do not reach the periphery". Cell Reports 42 10 (2023): 113230. http://dx.doi.org/10.1016/j.celrep.2023.113230.
    10.1016/j.celrep.2023.113230
  3. Srinivasan, Jayashree; Vasudev, Anusha; Shasha, Carolyn; Selden, Hilary J.; Perez, Encarnacion; LaFleur, Bonnie; Sinari, Shripad A.; et al. "The initial age-associated decline in early T-cell progenitors reflects fewer pre-thymic progenitors and altered signals in the bone marrow and thymus microenvironments". Aging Cell 22 8 (2023): http://dx.doi.org/10.1111/acel.13870.
    10.1111/acel.13870
  4. Chen, Jinbiao; Zhao, Yang; Zhang, Fan; Li, Jia; Boland, Jade A.; Cheng, Ngan Ching; Liu, Ken; et al. "Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7". Cellular and Molecular Life Sciences 79 8 (2022): http://dx.doi.org/10.1007/s00018-022-04452-6.
    10.1007/s00018-022-04452-6
  5. Krueger, Andreas; Lyszkiewicz, Marcin; Heissmeyer, Vigo. Autor correspondente: Krueger, Andreas. "Post-transcriptional control of T-cell development in the thymus". Immunology Letters 247 (2022): 1-12. http://dx.doi.org/10.1016/j.imlet.2022.04.009.
    10.1016/j.imlet.2022.04.009
  6. Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Abrignani, Sergio; Addo, Richard; Akdis, Mübeccel; Andrä, Immanuel; et al. "Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)". European Journal of Immunology 51 12 (2021): 2708-3145. http://dx.doi.org/10.1002/eji.202170126.
    10.1002/eji.202170126
  7. Coppin, Emilie; Sundarasetty, Bala Sai; Rahmig, Susann; Blume, Jonas; Verheyden, Nikita A.; Bahlmann, Franz; Ravens, Sarina; et al. "Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7". Leukemia 35 12 (2021): 3561-3567. http://dx.doi.org/10.1038/s41375-021-01259-5.
    10.1038/s41375-021-01259-5
  8. Meyer, Annekarin; Herkt, Stefanie; Kunze-Schumacher, Heike; Kohrs, Nicole; Ringleb, Julia; Schneider, Lucas; Kuvardina, Olga N.; et al. "The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-78629-z.
    10.1038/s41598-020-78629-z
  9. Kunze-Schumacher, Heike; Krueger, Andreas. "The Role of MicroRNAs in Development and Function of Regulatory T Cells – Lessons for a Better Understanding of MicroRNA Biology". Frontiers in Immunology 11 (2020): http://dx.doi.org/10.3389/fimmu.2020.02185.
    10.3389/fimmu.2020.02185
  10. Zoe Grewers; Andreas Krueger. "MicroRNA miR-181 - A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21176200.
    10.3390/ijms21176200
  11. Witkowski, Marco; Witkowski, Mario; Saffarzadeh, Mona; Friebel, Julian; Tabaraie, Termeh; Ta Bao, Loc; Chakraborty, Aritra; et al. "Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes". Cardiovascular Diabetology 19 1 (2020): http://dx.doi.org/10.1186/s12933-020-0993-z.
    10.1186/s12933-020-0993-z
  12. Amado, Tiago; Amorim, Ana; Enguita, Francisco J.; Romero, Paula V.; Inácio, Daniel; de Miranda, Marta Pires; Winter, Samantha J.; et al. "MicroRNA-181a regulates IFN-g expression in effector CD8+ T cell differentiation". Journal of Molecular Medicine 98 2 (2020): 309-320. http://dx.doi.org/10.1007/s00109-019-01865-y.
    10.1007/s00109-019-01865-y
  13. Winter, Samantha J.; Krueger, Andreas. "Development of Unconventional T Cells Controlled by MicroRNA". Frontiers in Immunology 10 (2019): http://dx.doi.org/10.3389/fimmu.2019.02520.
    10.3389/fimmu.2019.02520
  14. Maluski, Marcel; Ghosh, Arnab; Herbst, Jessica; Scholl, Vanessa; Baumann, Rolf; Huehn, Jochen; Geffers, Robert; et al. "Chimeric antigen receptor–induced BCL11B suppression propagates NK-like cell development". Journal of Clinical Investigation 129 12 (2019): 5108-5122. http://dx.doi.org/10.1172/jci126350.
    10.1172/jci126350
  15. Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Acs, Andreas; Adam, Dieter; Adam-Klages, Sabine; Agace, William W.; et al. "Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)". European Journal of Immunology 49 10 (2019): 1457-1973. http://dx.doi.org/10.1002/eji.201970107.
    10.1002/eji.201970107
  16. Lyszkiewicz, Marcin; Kotlarz, Daniel; Zi¿tara, Natalia; Brandes, Gudrun; Diestelhorst, Jana; Glage, Silke; Hobeika, Elias; et al. "LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking". Frontiers in Immunology 10 (2019): http://dx.doi.org/10.3389/fimmu.2019.00497.
    10.3389/fimmu.2019.00497
  17. Lyszkiewicz, Marcin; Winter, Samantha J.; Witzlau, Katrin; Föhse, Lisa; Brownlie, Rebecca; Puchalka, Jacek; Verheyden, Nikita A.; et al. "miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity". PLOS Biology 17 3 (2019): e2006716. http://dx.doi.org/10.1371/journal.pbio.2006716.
    10.1371/journal.pbio.2006716
  18. Ronkina, N.; Schuster-Gossler, K.; Hansmann, F.; Kunze-Schumacher, H.; Sandrock, I.; Yakovleva, T.; Lafera, J.; et al. "Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3". Molecular and Cellular Biology 39 6 (2019): http://dx.doi.org/10.1128/mcb.00516-18.
    10.1128/mcb.00516-18
  19. Sandrock, Inga; Reinhardt, Annika; Ravens, Sarina; Binz, Christoph; Wilharm, Anneke; Martins, Joana; Oberdörfer, Linda; et al. "Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing gd T cells". Journal of Experimental Medicine 215 12 (2018): 3006-3018. http://dx.doi.org/10.1084/jem.20181439.
    10.1084/jem.20181439
  20. Winter, Samantha J; Kunze-Schumacher, Heike; Imelmann, Esther; Grewers, Zoe; Osthues, Tabea; Krueger, Andreas. "MicroRNA miR-181a/b-1 controls MAIT cell development". Immunology and Cell Biology 97 2 (2018): 190-202. http://dx.doi.org/10.1111/imcb.12211.
    10.1111/imcb.12211
  21. Kunze-Schumacher, Heike; Winter, Samantha J.; Imelmann, Esther; Krueger, Andreas. "miRNA miR-21 Is Largely Dispensable for Intrathymic T-Cell Development". Frontiers in Immunology 9 (2018): http://dx.doi.org/10.3389/fimmu.2018.02497.
    10.3389/fimmu.2018.02497
  22. Blume, Jonas; Zietara, Natalia; Witzlau, Katrin; Liu, Yanshan; Sanchez, Oskar Ortiz; Puchalka, Jacek; Winter, Samantha J.; et al. "miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1". European Journal of Immunology 49 1 (2018): 121-132. http://dx.doi.org/10.1002/eji.201847660.
    10.1002/eji.201847660
  23. Koenecke, Christian; Krueger, Andreas. "MicroRNA in T-Cell Development and T-Cell Mediated Acute Graft-Versus-Host Disease". Frontiers in Immunology 9 (2018): http://dx.doi.org/10.3389/fimmu.2018.00992.
    10.3389/fimmu.2018.00992
  24. Glaesener, Stephanie; Jaenke, Christine; Habener, Anika; Geffers, Robert; Hagendorff, Petra; Witzlau, Katrin; Imelmann, Esther; Krueger, Andreas; Meyer-Bahlburg, Almut. "Decreased production of class-switched antibodies in neonatal B cells is associated with increased expression of miR-181b". PLOS ONE 13 2 (2018): e0192230. http://dx.doi.org/10.1371/journal.pone.0192230.
    10.1371/journal.pone.0192230
  25. Krueger, Andreas. "Thymus Colonization: Who, How, How Many?". Archivum Immunologiae et Therapiae Experimentalis 66 2 (2017): 81-88. http://dx.doi.org/10.1007/s00005-017-0503-5.
    10.1007/s00005-017-0503-5
  26. Krueger, Andreas; Zietara, Natalia; Lyszkiewicz, Marcin. "T Cell Development by the Numbers". Trends in Immunology 38 2 (2017): 128-139. http://dx.doi.org/10.1016/j.it.2016.10.007.
    10.1016/j.it.2016.10.007
  27. Salari, Azam; Thomay, Kathrin; Himmler, Kirsten; Vajen, Beate; Schienke, Andrea; Hagedorn, Maike; Ebersold, Juliane; et al. "Establishing a murine xenograft-model for long-term analysis of factors inducing chromosomal instability in myelodysplastic syndrome: Pitfalls and successes". Cancer Genetics 209 6 (2016): 258-266. http://dx.doi.org/10.1016/j.cancergen.2016.04.004.
    10.1016/j.cancergen.2016.04.004
  28. Blume, Jonas; Lage, Susanne; Witzlau, Katrin; Georgiev, Hristo; Weiss, Siegfried; Lyszkiewicz, Marcin; Zi¿tara, Natalia; Krueger, Andreas. "Overexpression of Va14Ja18 TCR promotes development of iNKT cells in the absence of miR-181a/b-1". Immunology & Cell Biology 94 8 (2016): 741-746. http://dx.doi.org/10.1038/icb.2016.40.
    10.1038/icb.2016.40
  29. Lee, Chun-Wei; Wohlan, Katharina; Dallmann, Iris; Förster, Reinhold; Ganser, Arnold; Krueger, Andreas; Scherr, Michaela; Eder, Matthias; Koenecke, Christian. "miR-181a Expression in Donor T Cells Modulates Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation". The Journal of Immunology 196 9 (2016): 3927-3934. http://dx.doi.org/10.4049/jimmunol.1502152.
    10.4049/jimmunol.1502152
  30. Sandrock, Inga; Zietara, Natalia; Lyszkiewicz, Marcin; Oberdörfer, Linda; Witzlau, Katrin; Krueger, Andreas; Prinz, Immo. "MicroRNA-181a/b-1 Is Not Required for Innate gd NKT Effector Cell Development". PLOS ONE 10 12 (2015): e0145010. http://dx.doi.org/10.1371/journal.pone.0145010.
    10.1371/journal.pone.0145010
  31. Regelin, Malte; Blume, Jonas; Pommerencke, Jens; Vakilzadeh, Ramin; Witzlau, Katrin; Lyszkiewicz, Marcin; Zietara, Natalia; et al. "Responsiveness of Developing T Cells to IL-7 Signals Is Sustained by miR-17~92". The Journal of Immunology 195 10 (2015): 4832-4840. http://dx.doi.org/10.4049/jimmunol.1402248.
    10.4049/jimmunol.1402248
  32. Zietara, Natalia; Lyszkiewicz, Marcin; Puchalka, Jacek; Witzlau, Katrin; Reinhardt, Annika; Förster, Reinhold; Pabst, Oliver; Prinz, Immo; Krueger, Andreas. "Multicongenic fate mapping quantification of dynamics of thymus colonization". Journal of Experimental Medicine 212 10 (2015): 1589-1601. http://dx.doi.org/10.1084/jem.20142143.
    10.1084/jem.20142143
  33. Lyszkiewicz, Marcin; Zietara, Natalia; Föhse, Lisa; Puchalka, Jacek; Diestelhorst, Jana; Witzlau, Katrin; Prinz, Immo; Schambach, Axel; Krueger, Andreas. "Limited niche availability suppresses murine intrathymic dendritic-cell development from noncommitted progenitors". Blood 125 3 (2015): 457-464. http://dx.doi.org/10.1182/blood-2014-07-592667.
    10.1182/blood-2014-07-592667
  34. Ugur, Milas; Schulz, Olga; Menon, Manoj B.; Krueger, Andreas; Pabst, Oliver. "Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure". Nature Communications 5 1 (2014): http://dx.doi.org/10.1038/ncomms5821.
    10.1038/ncomms5821
  35. Braune, E.-B.; Schuster-Gossler, K.; Lyszkiewicz, M.; Serth, K.; Preusse, K.; Madlung, J.; Macek, B.; Krueger, A.; Gossler, A.. "S/T Phosphorylation of DLL1 Is Required for Full Ligand Activity In Vitro but Dispensable for DLL1 Function In Vivo during Embryonic Patterning and Marginal Zone B Cell Development". Molecular and Cellular Biology 34 7 (2014): 1221-1233. http://dx.doi.org/10.1128/mcb.00965-13.
    10.1128/mcb.00965-13
  36. Zietara, Natalia; Lyszkiewicz, Marcin; Krueger, Andreas; Weiss, Siegfried. "B-cell modulation of dendritic-cell function: Signals from the far side". European Journal of Immunology 44 1 (2014): 23-32. http://dx.doi.org/10.1002/eji.201344007.
    10.1002/eji.201344007
  37. Schulz, O; Ugur, M; Friedrichsen, M; Radulovic, K; Niess, J-H; Jalkanen, S; Krueger, A; Pabst, O. "Hypertrophy of infected Peyer’s patches arises from global, interferon-receptor, and CD69-independent shutdown of lymphocyte egress". Mucosal Immunology 7 4 (2013): 892-904. http://dx.doi.org/10.1038/mi.2013.105.
    10.1038/mi.2013.105
  38. Zietara, N.; Lyszkiewicz, M.; Witzlau, K.; Naumann, R.; Hurwitz, R.; Langemeier, J.; Bohne, J.; et al. "Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells". Proceedings of the National Academy of Sciences 110 18 (2013): 7407-7412. http://dx.doi.org/10.1073/pnas.1221984110.
    10.1073/pnas.1221984110
  39. Zietara, N.; Lyszkiewicz, M.; Puchalka, J.; Pei, G.; Gutierrez, M. G.; Lienenklaus, S.; Hobeika, E.; et al. "Immunoglobulins drive terminal maturation of splenic dendritic cells". Proceedings of the National Academy of Sciences 110 6 (2013): 2282-2287. http://dx.doi.org/10.1073/pnas.1210654110.
    10.1073/pnas.1210654110
  40. Haas, Jan D.; Ravens, Sarina; Düber, Sandra; Sandrock, Inga; Oberdörfer, Linda; Kashani, Elham; Chennupati, Vijaykumar; et al. "Development of Interleukin-17-Producing gd T Cells Is Restricted to a Functional Embryonic Wave". Immunity 37 1 (2012): 48-59. http://dx.doi.org/10.1016/j.immuni.2012.06.003.
    10.1016/j.immuni.2012.06.003
  41. Saran, Namita; Pommerencke, Jens; Witzlau, Katrin; Regelin, Malte; Krueger, Andreas. "Extra-Thymic Physiological T Lineage Progenitor Activity Is Exclusively Confined to Cells Expressing either CD127, CD90, or High Levels of CD117". PLoS ONE 7 2 (2012): e30864. http://dx.doi.org/10.1371/journal.pone.0030864.
    10.1371/journal.pone.0030864
  42. Zietara, Natalia; Lyszkiewicz, Marcin; Krueger, Andreas; Weiss, Siegfried. "ICOS-dependent stimulation of NKT cells by marginal zone B cells". European Journal of Immunology 41 11 (2011): 3125-3134. http://dx.doi.org/10.1002/eji.201041092.
    10.1002/eji.201041092
  43. Krueger, Andreas. "A missing link in thymic dendritic cell development". European Journal of Immunology 41 8 (2011): 2145-2147. http://dx.doi.org/10.1002/eji.201141850.
    10.1002/eji.201141850
  44. Haas, Jan D.; Nistala, Kiran; Petermann, Franziska; Saran, Namita; Chennupati, Vijaykumar; Schmitz, Susanne; Korn, Thomas; et al. "Expression of miRNAs miR-133b and miR-206 in the Il17a/f Locus Is Co-Regulated with IL-17 Production in aß and gd T Cells". PLoS ONE 6 5 (2011): e20171. http://dx.doi.org/10.1371/journal.pone.0020171.
    10.1371/journal.pone.0020171
  45. Surdziel, Ewa; Cabanski, Maciej; Dallmann, Iris; Lyszkiewicz, Marcin; Krueger, Andreas; Ganser, Arnold; Scherr, Michaela; Eder, Matthias. "Enforced expression of miR-125b affects myelopoiesis by targeting multiple signaling pathways". Blood 117 16 (2011): 4338-4348. http://dx.doi.org/10.1182/blood-2010-06-289058.
    10.1182/blood-2010-06-289058
  46. Lyszkiewicz, Marcin; Witzlau, Katrin; Pommerencke, Jens; Krueger, Andreas. "Chemokine receptor CX3CR1 promotes dendritic cell development under steady-state conditions". European Journal of Immunology 41 5 (2011): 1256-1265. http://dx.doi.org/10.1002/eji.201040977.
    10.1002/eji.201040977
  47. Krueger, Andreas; Willenzon, Stefanie; Lyszkiewicz, Marcin; Kremmer, Elisabeth; Förster, Reinhold. "CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus". Blood 115 10 (2010): 1906-1912. http://dx.doi.org/10.1182/blood-2009-07-235721.
    10.1182/blood-2009-07-235721
  48. Saran, Namita; Lyszkiewicz, Marcin; Pommerencke, Jens; Witzlau, Katrin; Vakilzadeh, Ramin; Ballmaier, Matthias; von Boehmer, Harald; Krueger, Andreas. "Multiple extrathymic precursors contribute to T-cell development with different kinetics". Blood 115 6 (2010): 1137-1144. http://dx.doi.org/10.1182/blood-2009-07-230821.
    10.1182/blood-2009-07-230821
  49. Weber, Claudia; Krueger, Andreas; Münk, Anika; Bode, Constantin; Van Veldhoven, Paul P.; Gräler, Markus H.. "Discontinued Postnatal Thymocyte Development in Sphingosine 1-Phosphate-Lyase-Deficient Mice". The Journal of Immunology 183 7 (2009): 4292-4301. http://dx.doi.org/10.4049/jimmunol.0901724.
    10.4049/jimmunol.0901724
  50. Kreslavsky, Taras; Garbe, Annette I.; Krueger, Andreas; von Boehmer, Harald. "T cell receptor-instructed ab versus gd lineage commitment revealed by single-cell analysis". Journal of Experimental Medicine 205 5 (2008): 1173-1186. http://dx.doi.org/10.1084/jem.20072425.
    10.1084/jem.20072425
  51. Junt, T.; Schulze, H.; Chen, Z.; Massberg, S.; Goerge, T.; Krueger, A.; Wagner, D. D.; et al. "Dynamic Visualization of Thrombopoiesis Within Bone Marrow". Science 317 5845 (2007): 1767-1770. http://dx.doi.org/10.1126/science.1146304.
    10.1126/science.1146304
  52. Krueger, Andreas; von Boehmer, Harald. "Identification of a T Lineage-Committed Progenitor in Adult Blood". Immunity 26 1 (2007): 105-116. http://dx.doi.org/10.1016/j.immuni.2006.12.004.
    10.1016/j.immuni.2006.12.004
  53. Fas, Stefanie C.; Baumann, Sven; Krueger, Andreas; Frey, Christian R.; Schulze-Bergkamen, Henning; Brenner, Dirk; Stumpf, Christine; Kappes, Kathrin; Krammer, Peter H.. "In vitro generated human memory-like T cells are CD95 type II cells and resistant towards CD95-mediated apoptosis". European Journal of Immunology 36 11 (2006): 2894-2903. http://dx.doi.org/10.1002/eji.200635925.
    10.1002/eji.200635925
  54. Dose, Marei; Khan, Irum; Guo, Zhuyan; Kovalovsky, Damian; Krueger, Andreas; von Boehmer, Harald; Khazaie, Khashayarsha; Gounari, Fotini. "c-Myc mediates pre-TCR-induced proliferation but not developmental progression". Blood 108 8 (2006): 2669-2677. http://dx.doi.org/10.1182/blood-2006-02-005900.
    10.1182/blood-2006-02-005900
  55. Krueger, Andreas; Garbe, Annette I.; von Boehmer, Harald. "Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands". Journal of Experimental Medicine 203 8 (2006): 1977-1984. http://dx.doi.org/10.1084/jem.20060731.
    10.1084/jem.20060731
  56. Garbe, Annette I.; Krueger, Andreas; Gounari, Fotini; Zu´n~iga-Pflu¨cker, Juan Carlos; von Boehmer, Harald. "Differential synergy of Notch and T cell receptor signaling determines ab versus gd lineage fate". Journal of Experimental Medicine 203 6 (2006): 1579-1590. http://dx.doi.org/10.1084/jem.20060474.
    10.1084/jem.20060474
  57. Krueger, Andreas; Fas, Stefanie C.; Giaisi, Marco; Bleumink, Marc; Merling, Anette; Stumpf, Christine; Baumann, Sven; et al. "HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP)". Blood 107 10 (2006): 3933-3939. http://dx.doi.org/10.1182/blood-2005-06-2567.
    10.1182/blood-2005-06-2567
  58. Golks, A; Brenner, D; Schmitz, I; Watzl, C; Krueger, A; Krammer, P H; Lavrik, I N. "The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation". Cell Death & Differentiation 13 3 (2005): 489-498. http://dx.doi.org/10.1038/sj.cdd.4401766.
    10.1038/sj.cdd.4401766
  59. Baumann, Sven; Dostert, Anja; Novac, Natalia; Bauer, Anton; Schmid, Wolfgang; Fas, Stefanie C.; Krueger, Andreas; et al. "Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer". Blood 106 2 (2005): 617-625. http://dx.doi.org/10.1182/blood-2004-11-4390.
    10.1182/blood-2004-11-4390
  60. Beier, C.P.; Wischhusen, J.; Gleichmann, M.; Gerhardt, E.; Pekanovic, A.; Krueger, A.; Taylor, V.; et al. "FasL (CD95L/APO-1L) resistance of neurons mediated by phosphatidylinositol 3-kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane protein 35". Journal of Neuroscience 25 29 (2005): 6765-6774. http://dx.doi.org/10.1523/jneurosci.1700-05.2005.
    10.1523/JNEUROSCI.1700-05.2005
  61. Eichhorst, Sören T; Krueger, Andreas; Müerköster, Susanne; Fas, Stefanie C; Golks, Alexander; Gruetzner, Uwe; Schubert, Louise; et al. "Suramin inhibits death receptor–induced apoptosis in vitro and fulminant apoptotic liver damage in mice". Nature Medicine 10 6 (2004): 602-609. http://dx.doi.org/10.1038/nm1049.
    10.1038/nm1049
  62. Ganten, T M; Haas, T L; Sykora, J; Stahl, H; Sprick, M R; Fas, S C; Krueger, A; et al. "Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs". Cell Death & Differentiation 11 S1 (2004): S86-S96. http://dx.doi.org/10.1038/sj.cdd.4401437.
    10.1038/sj.cdd.4401437
  63. Finzer, Patrick; Krueger, Andreas; Stöhr, Michael; Brenner, Dirk; Soto, Ubaldo; Kuntzen, Christian; Krammer, Peter H; Rösl, Frank. "HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F–p73 pathway". Oncogene 23 28 (2004): 4807-4817. http://dx.doi.org/10.1038/sj.onc.1207620.
    10.1038/sj.onc.1207620
  64. Schulze-Bergkamen, Henning; Brenner, Dirk; Krueger, Andreas; Suess, Dorothee; Fas, Stefanie C.; Frey, Christian R.; Dax, Andreas; et al. "Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt". Hepatology 39 3 (2004): 645-654. http://dx.doi.org/10.1002/hep.20138.
    10.1002/hep.20138
  65. Schmitz, Ingo; Weyd, Heiko; Krueger, Andreas; Baumann, Sven; Fas, Stefanie C.; Krammer, Peter H.; Kirchhoff, Sabine. "Resistance of Short Term Activated T Cells to CD95-Mediated Apoptosis Correlates with De Novo Protein Synthesis of c-FLIPshort". The Journal of Immunology 172 4 (2004): 2194-2200. http://dx.doi.org/10.4049/jimmunol.172.4.2194.
    10.4049/jimmunol.172.4.2194
  66. Schmitz, Ingo; Krueger, Andreas; Baumann, Sven; Schulze-Bergkamen, Henning; Krammer, Peter H.; Kirchhoff, Sabine. "An IL-2-Dependent Switch Between CD95 Signaling Pathways Sensitizes Primary Human T Cells Toward CD95-Mediated Activation-Induced Cell Death". The Journal of Immunology 171 6 (2003): 2930-2936. http://dx.doi.org/10.4049/jimmunol.171.6.2930.
    10.4049/jimmunol.171.6.2930
  67. Krueger, Andreas; Fas, Stefanie C.; Baumann, Sven; Krammer, Peter H.. "The role of CD95 in the regulation of peripheral T-cell apoptosis". Immunological Reviews 193 1 (2003): 58-69. http://dx.doi.org/10.1034/j.1600-065x.2003.00047.x.
    10.1034/j.1600-065x.2003.00047.x
  68. Baumann, Sven; Hess, Jochen; Eichhorst, Sören T; Krueger, Andreas; Angel, Peter; Krammer, Peter H; Kirchhoff, Sabine. "An unexpected role for FosB in activation-induced cell death of T cells". Oncogene 22 9 (2003): 1333-1339. http://dx.doi.org/10.1038/sj.onc.1206126.
    10.1038/sj.onc.1206126
  69. Lavrik, I; Krueger, A; Schmitz, I; Baumann, S; Weyd, H; Krammer, P H; Kirchhoff, S. "The active caspase-8 heterotetramer is formed at the CD95 DISC". Cell Death & Differentiation 10 1 (2003): 144-145. http://dx.doi.org/10.1038/sj.cdd.4401156.
    10.1038/sj.cdd.4401156
  70. Schmitz, Ingo; Krueger, Andreas; Baumann, Sven; Kirchhoff, Sabine; Krammer, Peter H. "Specificity of anti-human CD95 (APO-1/Fas) antibodies". Biochemical and Biophysical Research Communications 297 3 (2002): 459-462. http://dx.doi.org/10.1016/s0006-291x(02)02242-8.
    10.1016/s0006-291x(02)02242-8
  71. Baumann, Sven; Krueger, Andreas; Kirchhoff, Sabine; Krammer, Peter. "Regulation of T cell Apoptosis during the Immune Response". Current Molecular Medicine 2 3 (2002): 257-272. http://dx.doi.org/10.2174/1566524024605671.
    10.2174/1566524024605671
  72. Kirchhoff, Sabine; Sebens, Thorsten; Baumann, Sven; Krueger, Andreas; Zawatzky, Rainer; Li-Weber, Min; Meinl, Edgar; et al. "Viral IFN-Regulatory Factors Inhibit Activation-Induced Cell Death Via Two Positive Regulatory IFN-Regulatory Factor 1-Dependent Domains in the CD95 Ligand Promoter". The Journal of Immunology 168 3 (2002): 1226-1234. http://dx.doi.org/10.4049/jimmunol.168.3.1226.
    10.4049/jimmunol.168.3.1226
  73. Hentze, Hannes; Schmitz, Ingo; Latta, Markus; Krueger, Andreas; Krammer, Peter H.; Wendel, Albrecht. "Glutathione Dependence of Caspase-8 Activation at the Death-inducing Signaling Complex". Journal of Biological Chemistry 277 7 (2002): 5588-5595. http://dx.doi.org/10.1074/jbc.m110766200.
    10.1074/jbc.m110766200
  74. Krueger, Andreas; Baumann, Sven; Krammer, Peter H.; Kirchhoff, Sabine. "FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis". Molecular and Cellular Biology 21 24 (2001): 8247-8254. http://dx.doi.org/10.1128/mcb.21.24.8247-8254.2001.
    10.1128/mcb.21.24.8247-8254.2001
  75. Eckhart, Leopold; Henry, Michael; Santos-Beneit, Antonio M.; Schmitz, Ingo; Krueger, Andreas; Fischer, Heinz; Bach, Jürgen; et al. "Alternative Splicing of Caspase-8 mRNA during Differentiation of Human Leukocytes". Biochemical and Biophysical Research Communications 289 4 (2001): 777-781. http://dx.doi.org/10.1006/bbrc.2001.6055.
    10.1006/bbrc.2001.6055
  76. Krueger, Andreas; Schmitz, Ingo; Baumann, Sven; Krammer, Peter H.; Kirchhoff, Sabine. "Cellular FLICE-inhibitory Protein Splice Variants Inhibit Different Steps of Caspase-8 Activation at the CD95 Death-inducing Signaling Complex". Journal of Biological Chemistry 276 23 (2001): 20633-20640. http://dx.doi.org/10.1074/jbc.m101780200.
    10.1074/jbc.m101780200
  77. Chatterjee, D.; Schmitz, I.; Krueger, A.; Yeung, K.; Kirchhoff, S.; Krammer, P.H.; Peter, M.E.; Wyche, J.H.; Pantazis, P.. "Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIPshort". Cancer Research 61 19 (2001): 7148-7154. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035476242&partnerID=MN8TOARS.
  78. Kirchhoff, Sabine; Müller, Wolfgang W.; Krueger, Andreas; Schmitz, Ingo; Krammer, Peter H.. "TCR-Mediated Up-Regulation of c-FLIPshort Correlates with Resistance Toward CD95-Mediated Apoptosis by Blocking Death-Inducing Signaling Complex Activity". The Journal of Immunology 165 11 (2000): 6293-6300. http://dx.doi.org/10.4049/jimmunol.165.11.6293.
    10.4049/jimmunol.165.11.6293
Capítulo de livro
  1. Winter, Samantha J.; Krueger, Andreas. "Magnetic Bead-Based Enrichment of Murine MAIT Cells". In Methods in Molecular Biology, 299-305. Springer US, 2020.
    10.1007/978-1-0716-0207-2_19
Entrada de enciclopédia
  1. Krammer, Peter H.; Krueger, Andreas. "CD95/CD95 Ligand (Fas/FasL, APO-1/APO-1L)". In Wiley Encyclopedia of Molecular Medicine, 2001.
Pré-impressão
  1. Verheyden, Nikita A.; Klostermann, Melina; Brüggemann, Mirko; Scholz, Anica; Amr, Shady; Lichtenthaeler, Chiara; Münch, Christian; et al. Autor correspondente: Krueger, Andreas. "A high-resolution map of functional miR-181 response elements in the thymus reveals the role of coding sequence targeting and an alternative seed match". 2023. http://dx.doi.org/10.1101/2023.09.08.556730.
    10.1101/2023.09.08.556730
  2. Kunze-Schumacher, Heike; Verheyden, Nikita A.; Grewers, Zoe; Meyer-Hermann, Michael; Greiff, Victor; Robert, Philippe A.; Krueger, Andreas. Autor correspondente: Krueger, Andreas. "High-resolution mapping of cell-cycle dynamics during steady-state T-cell development and regenerationin vivo". 2023. http://dx.doi.org/10.1101/2023.06.14.544919.
    10.1101/2023.06.14.544919

Outros

Outra produção
  1. Modelling the Dynamics of T-Cell Development in the Thymus. 2021. Philippe Robert; Heike Kunze-Schumacher; Victor Greiff; Andreas Krueger. https://doi.org/10.20944/preprints202101.0388.v1.
    10.20944/preprints202101.0388.v1
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/09/01 - Atual Cell cycle dynamics in the thyms
Orientador
2022/11/01 - Atual The role of MAIT cells in lung pathophysiology
Orientador
2021/11/01 - Atual Metabolic requirements of MAIT cell development
Orientador
2017 - Atual Mapping cell cycle dynamics in the thymus
Orientador
Goethe-Universität Frankfurt am Main, Alemanha
2017 - Atual miR-181-mediated gene regulation
Orientador
Goethe-Universität Frankfurt am Main, Alemanha
2016 - Atual Since 2016 supervision of 4 Master theses
Orientador
Goethe-Universität Frankfurt am Main, Alemanha
2016 - 2019 The role of miR-181a/b-1 in thymic development
Orientador
Goethe-Universität Frankfurt am Main, Alemanha
2012 - 2015 miRNA in lymphocyte development and function
Orientador
Medizinische Hochschule Hannover, Alemanha
2008 - 2015 From 2008 to 2015 supervision of 6 Master theses
Orientador
Medizinische Hochschule Hannover, Alemanha
2009 - 2014 miRNA/transcription factor networks in hematopoiesis
Orientador
Medizinische Hochschule Hannover, Alemanha
2008 - 2013 Molecular signatures of lymphoid lineage development
Orientador
Medizinische Hochschule Hannover, Alemanha
2008 - 2012 The role of miR-17~92 in T-cell development
Orientador
Medizinische Hochschule Hannover, Alemanha
2007 - 2011 Identification and characterization of physiologic T cell precursors
Orientador
Medizinische Hochschule Hannover, Alemanha

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022/11/01 Characterization of ex vivo generated Lymphoid Progenitors and therapeutic perspectives
Vogal
 Pierre Gaudeaux (Doutoramento)
2019 MicroRNAs in the functional differentiation of T cells
Arguente principal
 Tiago Maria de Carvalho da Costa Amado (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2018 Since 2018 member of the jury for a total of 16 MD and PhD theses multiple (Outro)
Goethe-Universität Frankfurt am Main, Alemanha
2011 From 2011 to 2016 jury member of approximately 20 MD, PhD and Master theses multiple (Outro)
Medizinische Hochschule Hannover, Alemanha

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2014 - Atual Member of the FCT Clinical Medicine, Immunology and Infection panel
Membro
 Fundação para a Ciência e a Tecnologia

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2017 - Atual MSc Program Biochemistry, Topic: Immunology Goethe-Universität Frankfurt am Main, Alemanha
2015 - Atual MSc Program Molecular Medicine, Topics: Molecular Oncology and Immunology Goethe-Universität Frankfurt am Main, Alemanha
2008 - 2015 MSc Program Biomedicine, Topics: Basic and Advanced Immunology Medizinische Hochschule Hannover, Alemanha
2008 - 2015 MSc Program Biochemistry, Topics: Basic and Advanced Immunology Medizinische Hochschule Hannover, Alemanha
2008 - 2015 MD Program, Topic: Fundamental Immunology Medizinische Hochschule Hannover, Alemanha
2008 - 2015 PhD Program Infection Biology, Topic: Developmental Immunology Medizinische Hochschule Hannover, Alemanha
2007 - 2015 PhD Program Molecular Medicine, Developmental Immunology Medizinische Hochschule Hannover, Alemanha
2007 - 2015 PhD Program Regenerative Sciences, Topic: Regenerative Immunology Medizinische Hochschule Hannover, Alemanha

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2016 - Atual Exam and steering boards MSc Program Molecular Medicine
Membro
 Goethe-Universität Frankfurt am Main, Alemanha