Raquel Maria da Silva Graça Almeida (1813-08A3-87B9)

Curriculum Vitae

Raquel Maria da Silva Graça Almeida

I graduated in Biology in the Faculty of Sciences of the University of Porto. This was followed by a Master Degree in Oncobiology in the Faculty of Medicine of the University of Porto and a PhD degree in the same Faculty in 2000. Both Master and PhD studies were performed in collaboration between the Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup) and the University of Copenhagen, in the group of Professor Henrik Clausen, a world leader in the gycobiology field. From 2001 until 2004, I was a Post-Doc at Ipatimup, studying the transcriptional mechanisms involved in intestinal metaplasia, a preneoplastic lesion of the stomach. Since the Masters until the end of the Post-doc I has fellowships from the Portuguese Foundation of Science and Technology. Since 2004 I hold a tenure position as Researcher, first as Assistant researcher (until 2020) and later on as Principal researcher. In 2013, I established my own group “Differentiation and cancer” focusing on transcriptional and post-transcriptional regulatory mechanisms involved in gastrointestinal cancer progression and therapy resistance. Since the post-doc I have been involved in multiple teaching activities within the University of Porto, in Master and PhD courses, in the field of Oncobiology. Since 2013, I am Invited Assistant Professor at the Department of Biology in the Faculty of Sciences of University of Porto, where I am also involved in undergraduate courses, as lecturer, mainly in the field of molecular and cellular biology. In 2015, I moved with my research group to the Institute of Research in Health and Innovation (i3S), the largest biomedical research institute in Portugal that resulted from the fusion of three institutes of the University of Porto, one of them being Ipatimup. I was member of the Scientific Council of Ipatimup (until 2015) and since 2015 I am member of the Scientific Council of I3S. I have been elected as vice-coordinator of the Cancer Integrative program at i3S (2023-2026 mandate). From 2012 until 2016 I was President of the first fiscal council of The Portuguese Association for Cancer Research (ASPIC). Currently, I am ASPIC Ambassador. I participate in two COST Actions, EPITRAN (2017-2021) where I was member of the management committee and currently TRANSLACORE (2022-2026). I have coordinated 9 scientific projects (3 financed by FCT) and participated in 28. I have a long-standing experience in researcher supervision (2 Junior researchers and 6 postdocs) and in student supervision (11 PhD and 20 master students). I have published 78 papers and have an H Index = 33.

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Identificação

Identificação pessoal

Nome completo: Raquel Maria da Silva Graça Almeida

Nomes de citação

Almeida, Raquel

Identificadores de autor

Ciência ID: 1813-08A3-87B9
ORCID iD: 0000-0002-5622-1633

Endereços de correio eletrónico

ralmeida@ipatimup.pt (Profissional)

Telefones

Fax

225570799 (Profissional)

Telefone

220408800 (Profissional)

Telemóvel

966147626 (Pessoal)

Moradas

IPATIMUP and i3S. Rua Alfredo Allen, 208 , 4200-135, Porto, Porto, Portugal (Profissional)

Websites

www.ipatimup.pt (Profissional)
https://orcid.org/0000-0002-5622-1633 (Profissional)
https://www.scopus.com/authid/detail.uri?authorId=7102385830 (Profissional)
https://www.i3s.up.pt/ (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão
Português	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Francês	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador independente (B1)

Formação

	Grau	Classificação
2000 Concluído	Doutoramento em Biologia Humana (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal "Identification and characterization of a human Beta4Galactosyltransferase gene family" (TESE/DISSERTAÇÃO)	Aprovada por unanimidade (nota máxima)
1996 Concluído	Mestrado em Oncobiologia (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal "Establishment of a strategy using expressed sequence tags (ESTs) to characterize genes expressed in human gastric tissues and gastric carcinoma cell lines." (TESE/DISSERTAÇÃO)	Muito Bom (nota máxima)
1994 Concluído	Biologia (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal "Não se aplica" (TESE/DISSERTAÇÃO)	15/20

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2020/04/01 - Atual	Investigador principal (carreira) (Investigação)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

2004/07/01 - 2020/03/31	Investigador Auxiliar (carreira) (Investigação)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2000/11/01 - 2004/06/30	Pós-doutorado (Investigação)	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
	Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2013/12/01 - Atual	Professor Auxiliar Convidado (Docente Universitário)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Faculdade de Ciências, Portugal

Projetos

Bolsa

	Designação	Financiadores
2022/01/01 - 2024/12/31	diffNET - Restituir a diferenciação das células tumorais manipulando proteínas de ligação ao ARN PTDC/BIA-CEL/0456/2021 Investigador Fundação para a Ciência e a Tecnologia, Portugal	Em curso
2023/01/01 - 2024/06/30	Novos biomarcadores fecais para deteção precoce de lesões pré-malignas e cancro: Otimização do modelo atual de rastreio em cancro colorretal 2022.09051.PTDC Investigador	Em curso
2022/01/01 - 2024/06/30	ResistNET - Identifying RNA-binding proteins mediating therapy resistance regulatory networks in cancer NA Investigador Merck et Cie, Suiça	Em curso
2021/01/01 - 2023/06/30	Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets NORTE-01-0145-FEDER-000051 Investigador Comissao de Coordenacao e Desenvolvimento Regional do Norte, Portugal
2018/07/01 - 2021/06/30	ReProgram_Reconstructing the Program of Cancer Stem Cells PTDC/MED-ONC/29017/2017 Investigador responsável Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/07/01 - 2021/06/30	OVABLOCK: Blocking MUC16-mesothelin interaction to abrogate peritoneal metastization of ovarian cancer POCI-01-0145-FEDER-029503 Investigador Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2017/01/01 - 2020/12/31	Cancel-Stem POCI-01-0145-FEDER-016390 Investigador Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/07/01 - 2020/06/30	inSTEM: A novel post-transcriptional regulatory network controlling intestinal stem cells fate POCI-01-0145-FEDER-031538 Investigador Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2016/05/01 - 2019/12/31	Advancing cancer research: from basic knowledge to application NORTE–01–0145–FEDER–000029 Investigador Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Concluído
2016/05/01 - 2019/12/31	Diabetes & obesity at the crossroads between Oncological and Cardiovascular diseases – a system analysis NETwork towards precision medicine (DOCnet) NORTE–01–0145–FEDER–000003 Investigador	Comissao de Coordenacao e Desenvolvimento Regional do Norte Concluído
2015/01/01 - 2016/12/31	StaTreat – Statins in gastric cancer treatment StaTreat Investigador responsável
2014/01/01 - 2015/12/31	Establishment of a knock-out mouse for MEX3A MEX3A Investigador responsável
2013/01/01 - 2015/12/31	Differentiation in cancer with emphasis on glycoproteome alterations Project P11-Norte-01-0124-FEDER-000024 Investigador	Concluído
2011/01/01 - 2014/03/31	Mucin MUC16 - CA125 cancer biomarker – biological functions and development of new biomarker assays PTDC/SAU-ONC/117216/2010 Investigador	Fundação para a Ciência e a Tecnologia
2012/01/01 - 2013/12/31	Modulating CDX2 expression in vivo using a nanoparticle-based strategy to deliver siRNAs Nano Investigador responsável	Concluído
2008/01/01 - 2011/12/31	Identification of signaling pathways mediated by MUC1 oncogene in gastric carcinoma cell lines and immortalized gastric normal cells PTDC/SAU-OBD/65616/2006 Investigador	Fundação para a Ciência e a Tecnologia Concluído
2008/01/01 - 2011/03/31	Autoregulação do CDX2 na reversibilidade/irreversibilidade da metaplasia intestinal gástrica PTDC/SAU-OBD/64490/2006 Investigador responsável	Fundação para a Ciência e a Tecnologia Concluído
2007/01/01 - 2010/07/31	Secretor and Lewis phenotypes/genotypes in Helicobacter pylori and calicivirus infection PTDC/SAU-MII/64153/2006 Investigador	Fundação para a Ciência e a Tecnologia Concluído
2005/01/01 - 2008/12/31	Genes associados à metaplasia intestinal da mucosa gástrica (mucina MUC2 e fucosiltransferase FUT3): regulação da transcrição e relevância para a adesão do Helicobacter pylori POCTI/SAU-OBS/55549/2004 Investigador	Fundação para a Ciência e a Tecnologia Concluído
2005/01/01 - 2008/12/31	Identificação de genes associados a glicosilação induzidos em células gástricas pelo Helicobacter pylori: “Glicómica” POCTI/SAU-OBS/56686/2004 Investigador	Fundação para a Ciência e a Tecnologia
2005/01/01 - 2008/03/31	Identificação de vias de sinalização envolvidas na regulação do Cdx2 em dois modelos humanos de diferenciação intestinal: metaplasia intestinal e polipose juvenil POCTI/SAU-OBS/55840/2004 Investigador responsável	Fundação para a Ciência e a Tecnologia
2003/01/01 - 2006/12/31	Clarification of the biological role of MUC1 mucin variability in gastric carcinogenesis POCTI/CBO/44812/2002 Investigador	Fundação para a Ciência e a Tecnologia
2003/01/01 - 2006/11/30	Molecular mechanisms of biosynthesis of altered mucin O-glycosylation in intestinal metaplasia POCTI/CBO/44598/2002 Investigador	Fundação para a Ciência e a Tecnologia
2002/01/01 - 2005/12/31	Regulation of aberrant MUC2 mucin gene expression in intestinal metaplasia, mucinous gastric carcinomas and gastric carcinoma cell lines: role of methylation and putative trascription factors POCTI/CBO/39075/2001; Investigador	Fundação para a Ciência e a Tecnologia Concluído
1997/01/01 - 2000/12/31	Characterization of genes expressed in gastric cells using expressed sequence tags PRAXIS XXI – 2/2.1/BIA/276/94 Outra	Fundação para a Ciência e a Tecnologia Concluído
1997/01 - 2000/12	Characterization of genes expressed in gastric cells using expressed sequence tags PRAXIS XXI – 2/2.1/BIA/276/94	Fundação para a Ciência e a Tecnologia

Outro

	Designação	Financiadores
2017/10/01 - 2021/12/31	EPITRAN – European Epitranscriptomics Network CA16120 Outra Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	European Commission Em curso

Produções

Publicações

Artigo em revista

Pádua, Diana; Figueira, Paula; Pinto, Mariana; Maia, André Filipe; Peixoto, Joana; Lima, Raquel T.; Pombinho, António; et al. "High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Gastric Cancer Stem-like Cells". Cancers 15 17 (2023): 4406. http://dx.doi.org/10.3390/cancers15174406.
10.3390/cancers15174406
Pimenta, Joana; Ribeiro, Ricardo; Almeida, Raquel; Costa, Pedro F.; da Silva, Marta A.; Pereira, Bruno. "Organ-on-Chip Approaches for Intestinal 3D In Vitro Modeling". Cellular and Molecular Gastroenterology and Hepatology 13 2 (2022): 351-367. http://dx.doi.org/10.1016/j.jcmgh.2021.08.015.
Acesso aberto • Publicado • 10.1016/j.jcmgh.2021.08.015
Pádua, Diana; Pinto, Débora Filipa; Figueira, Paula; Pereira, Carlos Filipe; Almeida, Raquel; Mesquita, Patrícia. "HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer". Current Oncology 29 1 (2021): 56-67. http://dx.doi.org/10.3390/curroncol29010005.
Acesso aberto • Publicado • 10.3390/curroncol29010005
Pereira, Carla; Park, Ji-Hyeon; Campelos, Sofia; Gullo, Irene; Lemos, Carolina; Solorzano, Leslie; Martins, Diana; et al. "Comparison of East-Asia and West-Europe cohorts explains disparities in survival outcomes and highlights predictive biomarkers of early gastric cancer aggressiveness". International Journal of Cancer 150 5 (2021): 868-880. http://dx.doi.org/10.1002/ijc.33872.
Publicado • 10.1002/ijc.33872
Sara Ribeirinho-Soares; Diana Pádua; Ana Luísa Amaral; Elvia Valentini; Daniela Azevedo; Cristiana Marques; Rita Barros; et al. "Prognostic significance of MUC2, CDX2 and SOX2 in stage II colorectal cancer patients". BMC Cancer (2021): https://doi.org/10.1186/s12885-021-08070-6.
10.1186/s12885-021-08070-6
Amaro, Helena M.; Barros, Rita; Tavares, Tânia; Almeida, Raquel; Pinto, Isabel Sousa; Malcata, Francisco Xavier; Guedes, Ana Catarina. "Gloeothece sp.—Exploiting a New Source of Antioxidant, Anti-Inflammatory, and Antitumor Agents". Marine Drugs 19 11 (2021): 623. http://dx.doi.org/10.3390/md19110623.
Acesso aberto • Publicado • 10.3390/md19110623
Almeida, Gabriela M; Pereira, Carla; Park, Ji-Hyeon; Lemos, Carolina; Campelos, Sofia; Gullo, Irene; Martins, Diana; et al. "CD44v6 High Membranous Expression Is a Predictive Marker of Therapy Response in Gastric Cancer Patients". Biomedicines 9 9 (2021): 1249. http://dx.doi.org/10.3390/biomedicines9091249.
Acesso aberto • Publicado • 10.3390/biomedicines9091249
Henriques, Taciane Barbosa; dos Santos, Diandra Zipinotti; dos Santos Guimarães, Isabella; Tessarollo, Nayara Gusmão; Lyra-Junior, Paulo Cilas Morais; Mesquita, Patricia; Pádua, Diana; et al. "Inhibition of CXCR2 plays a pivotal role in re-sensitizing ovarian cancer to cisplatin treatment". Aging 13 10 (2021): 13405-13420. http://dx.doi.org/10.18632/aging.203074.
Publicado • 10.18632/aging.203074
Solorzano, Leslie; Pereira, Carla; Martins, Diana; Almeida, Raquel; Carneiro, Fatima; Almeida, Gabriela M.; Oliveira, Carla; Wahlby, Carolina. "Towards Automatic Protein Co-Expression Quantification in Immunohistochemical TMA Slides". IEEE Journal of Biomedical and Health Informatics 25 2 (2021): 393-402. http://dx.doi.org/10.1109/jbhi.2020.3008821.
10.1109/jbhi.2020.3008821
Pádua, Diana; Figueira, Paula; Ribeiro, Inês; Almeida, Raquel; Mesquita, Patrícia. "The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00442.
10.3389/fcell.2020.00442
Coelho, Ricardo; Ricardo, Sara; Amaral, Ana Luísa; Huang, Yen-Lin; Nunes, Mariana; Neves, José Pedro; Mendes, Nuno; et al. "Regulation of invasion and peritoneal dissemination of ovarian cancer by mesothelin manipulation". Oncogenesis 9 6 (2020): http://dx.doi.org/10.1038/s41389-020-00246-2.
10.1038/s41389-020-00246-2
Pereira, Bruno; Amaral, Ana L; Dias, Alexandre; Mendes, Nuno; Muncan, Vanesa; Silva, Ana R; Thibert, Chantal; et al. "MEX3A regulates Lgr5 + stem cell maintenance in the developing intestinal epithelium". EMBO reports 21 4 (2020): http://dx.doi.org/10.15252/embr.201948938.
Acesso aberto • Publicado • 10.15252/embr.201948938
Lopes, Nair; Bergsland, Christian; Bruun, Jarle; Bjørnslett, Merete; Vieira, André Filipe; Mesquita, Patrícia; Pinto, Rita; et al. "A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis". Gastric Cancer (2020): http://dx.doi.org/10.1007/s10120-020-01064-6.
No prelo • 10.1007/s10120-020-01064-6
Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al. "A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin". Cancers 12 2 (2020): 495. http://dx.doi.org/10.3390/cancers12020495.
Acesso aberto • Publicado • 10.3390/cancers12020495
Carneiro, Patrícia; Moreira, Ana Margarida; Figueiredo, Joana; Barros, Rita; Oliveira, Patrícia; Fernandes, Maria Sofia; Ferro, Anabela; et al. "S100P is a molecular determinant of E-cadherin function in gastric cancer". Cell Communication and Signaling 17 1 (2019): http://dx.doi.org/10.1186/s12964-019-0465-9.
10.1186/s12964-019-0465-9
Lopes, Nair; Bergsland, Christian Holst; Bjørnslett, Merete; Pellinen, Teijo; Svindland, Aud; Nesbakken, Arild; Almeida, Raquel; et al. "Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2". Laboratory Investigation 100 1 (2019): 120-134. http://dx.doi.org/10.1038/s41374-019-0336-4.
10.1038/s41374-019-0336-4
Mesquita, Patrícia; Freire, Ana F.; Lopes, Nair; Gomes, Rosa; Azevedo, Daniela; Barros, Rita; Pereira, Bruno; et al. "Expression and Clinical Relevance of SOX9 in Gastric Cancer". Disease Markers 2019 (2019): 1-11. http://dx.doi.org/10.1155/2019/8267021.
10.1155/2019/8267021
Bruun, Jarle; Sveen, Anita; Barros, Rita; Eide, Peter W.; Eilertsen, Ina; Kolberg, Matthias; Pellinen, Teijo; et al. "Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer". Molecular Oncology 12 9 (2018): 1639-1655. http://dx.doi.org/10.1002/1878-0261.12347.
10.1002/1878-0261.12347
Rolim, I.; Rodrigues, R.V.; Bettencourt, A.; Barros, R.; Camilo, V.; Dias Pereira, A.; Almeida, R.; Chaves, P.. "Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway?". International Journal of Surgical Pathology 25 3 (2017): 262-265. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018354529&partnerID=MN8TOARS.
10.1177/1066896916672332
Pinto, R.; Hansen, L.; Hintze, J.; Almeida, R.; Larsen, S.; Coskun, M.; Davidsen, J.; et al. "Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression". Nucleic Acids Research 45 13 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85026430499&partnerID=MN8TOARS.
10.1093/nar/gkx371
Tsai, M.-H.; Lin, X.; Shumilov, A.; Bernhardt, K.; Feederle, R.; Poirey, R.; Kopp-Schneider, A.; et al. "The biological properties of different Epstein-Barr virus strains explain their association with various types of cancers". Oncotarget 8 6 (2017): 10238-10254. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012012695&partnerID=MN8TOARS.
10.18632/oncotarget.14380
Pereira, B.; Billaud, M.; Almeida, R.. "RNA-Binding Proteins in Cancer: Old Players and New Actors". Trends in Cancer 3 7 (2017): 506-528. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020932454&partnerID=MN8TOARS.
10.1016/j.trecan.2017.05.003
Oliveira, P.; Carvalho, J.; Rocha, S.; Azevedo, M.; Reis, I.; Camilo, V.; Sousa, B.; et al. "Dies1/VISTA expression loss is a recurrent event in gastric cancer due to epigenetic regulation". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84990946691&partnerID=MN8TOARS.
10.1038/srep34860
Sousa, A.M.; Rei, M.; Freitas, R.; Ricardo, S.; Caffrey, T.; David, L.; Almeida, R.; Hollingsworth, M.A.; Santos-Silva, F.. "Effect of MUC1/ß-catenin interaction on the tumorigenic capacity of pancreatic CD133⁺ cells". Oncology Letters 12 3 (2016): 1811-1817. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979697127&partnerID=MN8TOARS.
10.3892/ol.2016.4888
Sousa, A.M.; Grandgenett, P.M.; David, L.; Almeida, R.; Hollingsworth, M.A.; Santos-Silva, F.. "Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis". APMIS 124 11 (2016): 913-924. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982306248&partnerID=MN8TOARS.
10.1111/apm.12587
Sadio, A.; Amaral, A.L.; Nunes, R.; Ricardo, S.; Sarmento, B.; Almeida, R.; Tsukamoto, H.; das Neves, J.. "A mouse intra-intestinal infusion model and its application to the study of nanoparticle distribution". Frontiers in Physiology 7 NOV (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85006371437&partnerID=MN8TOARS.
10.3389/fphys.2016.00579
Rita Barros; Daniela Pereira; Catarina Callé; Vânia Camilo; Ana Isabel Cunha; Leonor David; Raquel Almeida; António Dias-Pereira; Paula Chaves. "Dynamics of SOX2 and CDX2 Expression in Barrett’s Mucosa". Disease Markers 2016 (2016): 1-7. http://dx.doi.org/10.1155/2016/1532791.
10.1155/2016/1532791
Pinto, Rita; Barros, Rita; Pereira-Castro, Isabel; Mesquita, Patricia; da Costa, Luis T.; Bennett, Eric P.; Almeida, Raquel; David, Leonor. "CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia". Laboratory Investigation 95 7 (2015): 718-727. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000357060000002&KeyUID=CCC:000357060000002.
Ricardo, Sara; Marcos-Silva, Lara; Pereira, Daniela; Pinto, Rita; Almeida, Raquel; Soderberg, Ola; Mandel, Ulla; et al. "Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours". Molecular Oncology 9 2 (2015): 503-512. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349582800014&KeyUID=WOS:000349582800014.
10.1016/j.molonc.2014.10.005
Camilo, Vania; Garrido, Monica; Valente, Pedro; Ricardo, Sara; Amaral, Ana Luisa; Barros, Rita; Chaves, Paula; et al. "Differentiation reprogramming in gastric intestinal metaplasia and dysplasia: role of SOX2 and CDX2". Histopathology 66 3 (2015): 343-350. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000348727200003&KeyUID=WOS:000348727200003.
10.1111/his.12544
Pinto, R.; Barros, R.; Pereira-Castro, I.; Mesquita, P.; Da Costa, L.T.; Bennett, E.P.; Almeida, R.; David, L.. "CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia". Laboratory Investigation 95 7 (2015): 718-727. http://www.scopus.com/inward/record.url?eid=2-s2.0-84933060097&partnerID=MN8TOARS.
10.1038/labinvest.2015.52
Camilo, Vania; Barros, Rita; Celestino, Ricardo; Castro, Patrcia; Vieira, Joana; Teixeira, Manuel R.; Carneiro, Fatima; et al. "Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome". Bmc Cancer 14 (2014):
10.1186/1471-2407-14-753
Sadio, Ana; Gustafsson, Jenny K.; Pereira, Bruno; Gomes, Carla Pereira; Hansson, Gunnar C.; David, Leonor; Pego, Ana Paula; Almeida, Raquel. "Modified-Chitosan/siRNA Nanoparticles Downregulate Cellular CDX2 Expression and Cross the Gastric Mucus Barrier". Plos One 9 6 (2014):
10.1371/journal.pone.0099449
Pereira, B.; Sousa, S.; Barros, R.; Carreto, L.; Oliveira, P.; Oliveira, C.; Chartier, N.T.; et al. "CDX2 regulation by the RNA-binding protein MEX3A: Impact on intestinal differentiation and stemness". Nucleic Acids Research 41 7 (2013): 3986-3999. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876542486&partnerID=MN8TOARS.
10.1093/nar/gkt087
Pereira, Bruno; Le Borgne, Mailys; Chartier, Nicolas T.; Billaud, Marc; Almeida, Raquel. "MEX-3 proteins: recent insights on novel post-trascriptional regulators". Trends in Biochemical Sciences 38 10 (2013): 477-479.
10.1016/j.tibs.2013.08.004
Peleteiro, B.; Lunet, N.; Wen, X.; Afonso, L.P.; Mendes, N.; Barros, R.; Carneiro, F.; Almeida, R.; Barros, H.. "Association between environmental factors and CDX2 expression in gastric cancer patients". European Journal of Cancer Prevention 21 5 (2012): 423-431. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864358456&partnerID=MN8TOARS.
10.1097/CEJ.0b013e32834ef1aa
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Outros

Outra produção

CD44v6 expression is a novel predictive marker of therapy response and poor prognosis in gastric cancer patients. 2018. Carla Pereira; Daniel Ferreira; Carolina Lemos; Diana Martins; Nuno Mendes; Daniela Almeida; Pedro Granja; et al. https://doi.org/10.1101/468934.
10.1101/468934

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2020/05/05	A SOX2 reporter system identifies gastric cancer stem-like cells sensitive to monensin	27th Porto Cancer Meeting Ipatimup (Porto, Portugal)
2019/04/06	Caracterização de células estaminais de cancro gástrico	Ciclo de conferências "Biologia ao Fim da Tarde" FCUP (Porto, Portugal)
2017/07/01	Cancer Stem Cells	35th Youth Science Meeting (Porto, Portugal)
2017/06/01	Characterization of a novel intestinal stem cell marker	One day symposium with Patrick Tan: Knowns and Unknowns in Gastric Cancer and Other Tumours of the Digestive System (Porto, Portugal)
2017/02/02	Stemness and differentiation markers in development and cancer	Group Leader Seminars i3S (porto, Portugal)
2017/02/01	Stemness and differentiation markers in development and cancer	UC-Biotech, Cantanhede
2014/06/02	Tissue regeneration with aberrant differentiation - stem cell reprogramming	Instituto Português de Oncologia (Lisboa, Portugal)
2014/04/01	Tissue regeneration with aberrant differentiation. Faculty of Pharmacy, University of Porto	Faculty of Pharmacy, University of Porto (Porto, Portugal)
2014/03/01	Intestinal metaplasia of the stomach: a model of tissue regeneration with aberrant differentiation.	INSERM/UJF U823 (Grenoble, França)
2012/07/06	CDX2 regulation in gastric intestinal metaplasia. Instituto Português de Oncologia	Instituto Português de Oncologia (Porto, Portugal)
2012/06/06	CDX2 and intestinal metaplasia	Instituto Português de Oncologia (Lisboa, Portugal)
2012/04/06	The Bone Morphogenetic Protein (BMP) pathway in gastric intestinal metaplasia	International Meeting of the Portuguese Society for Stem Cells & Cell Therapies (Porto, Portugal)
2012/04/05	Regulation of transdifferentiation in cancer development	SINAL 2012 - 6th National Meeting on Cell Signaling ICVS – ECSaúde (Braga, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2023/01/01 - 2026/12/31	Study of RNA-binding protein networks in colorectal cancer cells Coorientador de Alexandre Coelho	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/01/01 - 2025/12/31	RBPlasticity: RNA-binding proteins role in normal and malignant intestinal stem cell reprogramming Coorientador de Ana Rita Silva	Biomedicine (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2020/01/01 - 2023/12/31	Unveiling the molecular networks behind gastric cancer stem cells phenotype: the path for therapy success Orientador	Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/01 - 2023/12/31	Epitranscriptomics in gastric cancer: characterization of YTHDF3 function Orientador	Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09/01 - 2023/12/11	Exploring the relevance of marine animal venoms to treat cancer Orientador de Pedro Silva	Universidade do Porto, Portugal
2019/09/01 - 2020/07/31	A novel post-transcriptional regulatory network controlling intestinal stem cells fate Coorientador	Medicina e Oncologia Molecular (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2019/09/01 - 2020/07/31	Isolation and characterization of cancer stem cells (CSCs) from colorectal cancer –transcription factors involved in their reprogramming. Coorientador	Oncologia (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/09/01 - 2020/07/31	The epitranscriptome in gastric cancer: the role of m6A modification Orientador	Biologia Celular e Molecular (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2019/09/01 - 2020/07/31	UNVEILING THE TRANSCRIPTIONAL NETWORK BEHIND GASTRIC CANCER STEM CELLS PHENOTYPE Orientador	Medicina e Oncologia Molecular (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2014/01/01 - 2020/03/31	Molecular mechanisms of mucin MUC16 - Mesothelin interaction in ovarian cancer dissemination Coorientador	Biomedicina (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2018/09/01 - 2019/07/31	Role of the RNA-binding protein MEX3A in intestinal carcinogenesis Coorientador	Medicina e Oncologia Molecular (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2018/09/01 - 2019/07/31	Identificação de novos biomarcadores de prognóstico em cancro colorectal estadio II- papel da epitranscriptómica Orientador	Bioquímica (Licenciatura/Bacharelato) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/01 - 2019/06/30	Identification of new biomarkers in gastric cancer- the role of epitranscriptomics Orientador	Biologia (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2018/09/01 - 2019/06/30	Avaliação da expressão da RhoGTPase -AHRGAP18- e da sua relevância clinica no cancro gástrico Coorientador	Biologia (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2018/11/01 - 2019/05/31	Estudo da modulação da expressão de NAC1 e BCL6 na aquisição do fenótipo quimiorresistente aos derivados de platina e aos taxanos por células de câncer de ovário: papel do microambiente tumoral via expressão de CXCL2 e IL8 Coorientador	Universidade Federal do Espírito Santo, Brasil
2016/01/01 - 2018/12/31	Clinical biomarkers of stemness and immunity in the context of genetic heterogeneity in colorectal cancer. Post-Doc, Scientia Fellow Coorientador
2015/01/01 - 2018/12/31	Integrating Metabolic and Polarity Alterations in Cancer by post-transcriptional modulation of the LKB1-AMPK-mTOR axis (IMPACTOR): the role of the RNA-binding protein MEX3A Post-Doc (SFRH/BPD/109794/2015) Orientador
2015/01 - 2018/12/31	Genetic profile and clonal evolution of stomach premalignant conditions: detecting the point of no return in gastric carcinogenesis. Post-Doc (SFRH/BPD/99442/2014) Coorientador
2017/09/01 - 2018/11/30	New molecular prognostic and predictive biomarkers in stage II colorectal cancer Orientador	Bioquímica em Saúde (Mestrado) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2017/09/01 - 2018/06/30	Assessing the impact of SOX2 expression in gastric cancer cells using Comet assay Orientador	Biologia (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2017/09/01 - 2018/06/30	Study of post-transcriptional regulation of metabolic reprogramming of cancer cells Coorientador	Biologia (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2010/01/01 - 2017/12/31	Mouse models of intestinal metaplasia: exploring pathways from the TGF-beta superfamily. Post-Doc (SFRH/BPD/68276/2010) Orientador
2011/07/01 - 2017/12/21	Reverting Gastric Intestinal Metaplasia using siRNAs directed to CDX2 Orientador	Medicina e Oncologia Molecular (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2016/09/01 - 2017/11/30	Identifying a new intestinal stem cell marker with implications in development and cancer Orientador	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa, Portugal
2016/09/01 - 2017/10/31	Isolation and characterization of gastric cancer stem cells based on SOX2/OCT4 activity Orientador	Bioquímica (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/09/01 - 2017/06/30	Gastric organoid production: study of the impact of mutation in the MEX3A gene Orientador	Biologia (Licenciatura/Bacharelato) Universidade do Porto Faculdade de Ciências, Portugal
2015/09/01 - 2016/11/30	Reprogramação da diferenciação por miRNAs dependentes do CDX2 Orientador	Biotecnologia para as Ciências da Saúde (Mestrado) Universidade de Trás-os-Montes e Alto Douro, Portugal
2015/09/01 - 2016/07/31	SOX2 as a prognostic marker of treatment response in gastric cancer patients Coorientador	Medicina Universidade do Porto Faculdade de Medicina, Portugal
2011/01/01 - 2015/04/30	Cancer-associated sialyl-Tn carbohydrate antigen - regulation of its expression by CDX2 homeoprotein and contribution of mucin protein carriers for cancer progression Coorientador	Biomedicina (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2010/01/01 - 2014/11/30	Sox2 modulation in the establishment of CDX2-dependent intestinal metaplasia of the stomach Orientador	Biomedicina (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2013/09/01 - 2014/07/31	SOX2 and CDX2 in gastric intestinal metaplasia and dysplasia: impact on differentiation Orientador	Medicina (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2013/09/01 - 2014/07/01	Bone Morphogenetic proteins in the gastrointestinal tract Orientador	Medicina (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2012/09/01 - 2013/10/30	A model of BMP pathway overexpression in the gastrointestinal tract – an in vivo approach Orientador	Oncologia (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009/01/01 - 2013/04/30	Regulation of CDX2 expression by cellular interactions Orientador	Biomedicina (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2007/01/01 - 2010/12/31	Identification of signaling pathways involved in CDX2 regulation in metaplastic lesions Orientador	Biomedicina (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2007/09/01 - 2008/07/31	Study of the CDX2 gene regulation in gastric cell lines – emphasis on transcription factors GATA-4/-5 and -6 and SOX2 Orientador	Bioquímica (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007/09/01 - 2008/06/30	Estudo de polimorfismos no locus do gene CDX2 em Portugal e Moçambique Orientador	Medicina e Oncologia Molecular (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2004/09/01 - 2005/06/30	Papel da proteína SMAD4 na activação da transcrição do gene CDX2 no contexto da Metaplasia Intestinal Gástrica Orientador	Bioquímica (Licenciatura/Bacharelato) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2024/05/09 - 2024/05/10	XXX Porto Cancer Meeting - RNA biology in cancer: fundamentals and clinical relevance (2024/05/09 - 2024/05/10) Conferência (Membro da Comissão Organizadora)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/11/26 - 2020/11/27	Organoids without borders (2020/11/26 - 2020/11/27) Conferência (Coorganizador)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2024/04/05	Gene Regulatory Mechanisms and miRNA in Colonic Epithelial Diseases Arguente principal	Josephine Olsson (Doutoramento) Roskilde Universitet, Dinamarca
2023/04/02	Epigenetic regulation of non-coding RNAs in prostate cancer Arguente	Daniela Silva (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/12/14	m6ACODE: Deciphering the hidden message in m6A RNA methylation in Gastric Cancer Orientador	Diana Ferreira (Mestrado)
2021/12/02	Unravelling a cancer stem cell signature associated with breast cancer metastatic organotropism Arguente principal	Inês Conde (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2020/12/14	E-cadherin and CD44v6 in Gastric Cancer: Role, crosstalk and clinical implications Vogal	Carla Pereira (Doutoramento)
2020/03/08	Impact of Host Glycosylation in Tuberculosis Vogal	Kaori da Fonseca (Doutoramento)
2018/12/02	The relationship between naive pluripotency and X-chromosome inactivation Arguente	Elsa Sousa (Doutoramento)
2018/09/01	In vitro generation of cholangiocyte-like cells from human liver organoids Arguente principal	João Pedro Ferreira Faria (Mestrado)
2017/09/01	Mechanisms of AXL mediated cell plasticity and drug resistance Arguente principal	Stefan Hinz (Doutoramento)
2017/02/01	Relevance of MUC1 splice variants in pancreatic carcinogenesis Arguente	Andreia Mota de Sousa (Doutoramento)
2016/06/01	Clinical Implications and Regulation of Intestinal Stem Cell Markers in Colon Cancer Arguente principal	Maiken Espersen (Doutoramento)
2016/05/06	Mucins MUC16 and MUC1 are major carriers of SLea and SLex in borderline and malignant serous ovarian tumours Arguente principal	Cristina Lara Valente (Mestrado)
2016/02/01	In vivo evaluation of the role of DELTA-like 4/Notch signaling in the development of intestinal tumors Arguente principal	Marina Martins Badenes (Doutoramento)
2015/01/03	Health Communication: a new model to promote cancer prevention campaigns at schools Arguente	Ana Barros (Doutoramento)
2014/12/05	Transcriptional Regulation of the Mannosyltransferase-encoding gene PIGM in inherited Glysosylphosphatidylinositol (GPI) deficiency Arguente	Joana R. S. da Costa (Doutoramento)
2014/11/04	Dies1 gene expression and regulation in gastric cancer Arguente principal	Inês Calado Reis (Mestrado)
2014/11/03	Mucin MUC16 – CA125 cancer biomarker: biological functions and development of new biomarker assays Arguente	Lara Patrícia Marcos Silva (Doutoramento)
2014/01/06	The role of CDX2 in inflammatory bowel disease Arguente principal	Mehmet Coskun (Doutoramento)
2013/09/06	Signaling pathways activated by inflammatory cytokines can regulate genes involved in gastric carcinogenesis Arguente principal	Lara Cobler (Doutoramento)
2013/05/29	Mecanismos moleculares do esófago de Barrett Arguente principal	Isabel Saavedra (Mestrado)
2012/11/06	The role of Rac1-modulated gene transcription in tumorigenesis Arguente principal	Patrícia Alexandra Sousa Barros (Doutoramento)
2012/05/11	Mecanismos de regulação da diferenciação intestinal normal e metaplásica Arguente principal	Jaime Pereira Rodrigues (Mestrado)
2010/03/01	Identification of the HNF4-Alpha and CDX2 regulatory network Arguente principal	Mette Boyd (Doutoramento)
2009/12/10	Expressão das proteínas da via Smad-dependente do TGF-Beta em carcinoma papilar da tiroide Arguente principal	Joana Santos (Mestrado)

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2018/11/06 - 2018/11/06	Cancro colorretal em Portugal: da investigação à prevenção e ao tratamento	Porto, Portugal
2017/11/09 - 2017/11/10	6th i3S Annual Meeting	Póvoa de varzim, Portugal
2015/04/12 - 2015/04/13	XXIII Porto Cancer Meeting – Stem Cells and Cancer	Porto, Portugal
2012/10/25 - 2012/10/25	Launching Meeting da Associação Portuguesa de Investigação em Cancro (ASPIC) – “One day with Carlos Caldas	Porto, Portugal
2012/04/18 - 2012/04/20	International Meeting of the Portuguese Society for Stem Cells & Cell Therapies (7th SPCE-TC Meeting)	Porto, Portugal
2010/04/28 - 2010/04/29	XIX Porto Cancer Meeting - Differentiation, Regeneration and Cancer	Porto, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2017/12/01 - Atual	https://publons.com/researcher/1443811/raquel-almeida/

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2023/10/05 - 2023/12/04	MSCA-PF 2023 Avaliador	European Commission, Bélgica
2023/04/01 - 2023/06/12	Horizon Europe Health-Mission Cancer Avaliador	European Commission, Bélgica
2022/10/06 - 2022/12/02	MSCA-PF 2022 Avaliador	European Commission, Bélgica
2021/11/01 - 2022/01/31	MSCA-PF 2021 Avaliador	European Commission, Bélgica
2020/10/01 - 2020/12/10	Marie Sklodowska-Curie Individual Fellowships 2020
2019/10/01 - 2019/10/31	Marie Sklodowska-Curie Individual Fellowships 2019 Avaliador		European Commission
2018/10/01 - 2018/12/31	Marie Sklodowska-Curie Individual Fellowships 2018 Avaliador		European Commission

Membro de associação

	Nome da associação	Tipo de participação
2012/06/01 - Atual	ASPIC	Member of Fiscal Committee 2012-2016

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2018 - Atual	Comissão de Acompanhamento do Mestrado em Biologia Celular e Molecular Membro	Universidade do Porto Faculdade de Ciências, Portugal

Tutoria

	Tópico	Nome do aluno
2019/06/01 - 2019/09/30	Erasmus student: Identification of new biomarkers in gastric cancer - role of the epitranscriptome	Elvia Valentini

Distinções

Prémio

2022	Prémio Crioestaminal & SPCE-TC Regenerative Medicine Research Award