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Greetje Vande Velde. Published 56 articles in journals.
Identificação

Identificação pessoal

Nome completo
Greetje Vande Velde

Nomes de citação

  • Vande Velde, Greetje

Identificadores de autor

Ciência ID
2116-7B28-DF47
ORCID iD
0000-0002-5633-3993

Telefones

Telefone
  • (+32) 16324010 (Profissional)

Moradas

  • moSAIC, KU Leuven, Herestraat 49, box 505, 3000, Leuven, Leuven, Bélgica (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Radiologia, Medicina Nuclear e Imagens Médicas

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Holandês (Idioma materno)
Francês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2010
Concluído
 Biomedical Sciences (Doctor of Philosophy)
Katholieke Universiteit Leuven Departement Neurowetenschappen, Bélgica
2005
Concluído
 Science of Engineering (Master)
Katholieke Universiteit Leuven Faculteit Bio-Ingenieurswetenschappen, Bélgica
 Summa cum laude
2001
Concluído
 Medicine (Bachelor)
Katholieke Universiteit Leuven Faculteit Geneeskunde, Bélgica
 Cum laude
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2014/10 - 2017/09 Pós-doutorado (Investigação) Katholieke Universiteit Leuven Faculteit Geneeskunde, Bélgica
2015/01 - 2015/07 Pós-doutorado (Investigação) Centre for Genomic Regulation, Espanha

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/10 - Atual Professor Auxiliar (Docente Universitário) Katholieke Universiteit Leuven Faculteit Geneeskunde, Bélgica
Projetos

Bolsa

Designação Financiadores
2017 - Atual Novel anatomical and functional biomarkers for monitoring dynamics and therapy of lung diseases in preclinical rodent models
C2_2017
Investigador responsável
Katholieke Universiteit Leuven Groep Biomedische Wetenschappen, Bélgica

Outro

Designação Financiadores
2018 - Atual Understanding Down syndrome as a neuro-skeletal disorder: towards integrated treatment of brain, bones and cognition
FLJ_2018
Investigador responsável
Katholieke Universiteit Leuven Groep Biomedische Wetenschappen, Bélgica
Em curso
2018 - Atual Brain, bones and cognition: towards an integrated treatment in Down syndrome
FSMMD_2018
Investigador responsável
Katholieke Universiteit Leuven Groep Biomedische Wetenschappen, Bélgica
Em curso
2016 - 2018 CryptoVIEW: Unraveling host-pathogen interactions in the pathogenesis of cryptococcosis using optical and in vivo imaging methods
H2020_2016
Investigador
Concluído
2015 - 2018 Assessment of the impact of emerging azole resistance mechanisms on treatment response of invasive pulmonary aspergillosis using non-invasive imaging in experimental Aspergillus infection models
FWO_2015
Investigador responsável
Concluído
2015 - 2017 Longitudinal multimodal imaging of lung disease and therapy in preclinical models
KUIF_2015
Investigador responsável
Concluído
2014 - 2015 Can high-resolution optical projection tomography of the interplay between cryptococci and macrophages unravel the enigmas in pulmonary and cerebral cryptococcosis pathogenesis
BOF_2014
Investigador responsável
Produções

Publicações

Artigo em conferência
  1. Antoine D'Hollander; Dieter Fuchs; Bram Vanspauwen; Hilde Jans; Greetje Vande Velde; Liesbet Lagae; Uwe Himmelreich. "Branched gold nanoparticles for a combined photoacoustic imaging and photothermal therapy". 2012.
    10.1364/biomed.2012.bsu5a.1
  2. Rangarajan, J.R.; Loeckx, D.; Vande Velde, G.; Dresselaers, T.; Himmelreich, U.; Maes, F.; Suetens, P.. "Impact of RF inhomogeneity correction on image registration of micro MRI rodent brain images". 2011.
    10.1109/ISBI.2011.5872471
Artigo em revista
  1. Vanherp, Liesbeth; Poelmans, Jennifer; Hillen, Amy; Janbon, Guilhem; Brock, Matthias; Lagrou, Katrien; Vande Velde, Greetje; Himmelreich, Uwe. "The Added Value of Longitudinal Imaging for Preclinical In vivo Efficacy Testing of Therapeutic Compounds against Cerebral Cryptococcosis". Antimicrobial Agents and Chemotherapy (2020): http://dx.doi.org/10.1128/aac.00070-20.
    10.1128/aac.00070-20
  2. Katrien Van Dyck; Mary Ann Jabra-Rizk; Ona Rogiers; Greetje Vande Velde; Patrick Van Dijck. "Let’s shine a light on fungal infections: A noninvasive imaging toolbox". PLOS Pathogens (2020): https://doi.org/10.1371/journal.ppat.1008257.
    10.1371/journal.ppat.1008257
  3. Maxime De Rudder; Caroline Bouzin; Maxime Nachit; Heloïse Louvegny; Greetje Vande Velde; Yvon Julé; Isabelle A. Leclercq. "Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD/NASH". Laboratory Investigation (2020): https://doi.org/10.1038/s41374-019-0315-9.
    10.1038/s41374-019-0315-9
  4. Berghen, Nathalie; Dekoster, Kaat; Marien, Eyra; Dabin, Jérémie; Hillen, Amy; Wouters, Jens; Deferme, Jasmine; et al. "Radiosafe micro-computed tomography for longitudinal evaluation of murine disease models". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-53876-x.
    10.1038/s41598-019-53876-x
  5. Liesbeth Vanherp; Alexandra Ristani; Jennifer Poelmans; Amy Hillen; Katrien Lagrou; Guilhem Janbon; Matthias Brock; Uwe Himmelreich; Greetje Vande Velde. "Sensitive bioluminescence imaging of fungal dissemination to the brain in mouse models of cryptococcosis". Disease Models & Mechanisms (2019): dmm.039123-dmm.039123. https://doi.org/10.1242/dmm.039123.
    10.1242/dmm.039123
  6. Liesbeth Vanherp; Jennifer Poelmans; Amy Hillen; Kristof Govaerts; Sarah Belderbos; Tinne Buelens; Katrien Lagrou; Uwe Himmelreich; Greetje Vande Velde. "Bronchoscopic fibered confocal fluorescence microscopy for longitudinal in vivo assessment of pulmonary fungal infections in free-breathing mice". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-20545-4.
    10.1038/s41598-018-20545-4
  7. Janne Vignero; Nicholas W. Marshall; Greetje Vande Velde; Kristina Bliznakova; Hilde Bosmans; Rongxiao Zhang. "Translation from murine to human lung imaging using x-ray dark field radiography: A simulation study". PLOS ONE 13 10 (2018): e0206302-e0206302. https://doi.org/10.1371%2Fjournal.pone.0206302.
    10.1371/journal.pone.0206302
  8. J. Albers; S. Pacilé; M. A. Markus; M. Wiart; G. Vande Velde; G. Tromba; C. Dullin. "X-ray-Based 3D Virtual Histology—Adding the Next Dimension to Histological Analysis". Molecular Imaging and Biology 20 5 (2018): 732-741. https://doi.org/10.1007%2Fs11307-018-1246-3.
    10.1007/s11307-018-1246-3
  9. Jennifer Poelmans; Uwe Himmelreich; Liesbeth Vanherp; Luca Zhai; Amy Hillen; Bryan Holvoet; Sarah Belderbos; et al. "A Multimodal Imaging Approach Enables In Vivo Assessment of Antifungal Treatment in a Mouse Model of Invasive Pulmonary Aspergillosis". Antimicrobial Agents and Chemotherapy 62 7 (2018): https://doi.org/10.1128/AAC.00240-18.
    10.1128/AAC.00240-18
  10. Sofie Van Den Broucke; Lore Pollaris; Greetje Vande Velde; Erik Verbeken; Benoit Nemery; Jeroen Vanoirbeek; Peter Hoet. "Irritant-induced asthma to hypochlorite in mice due to impairment of the airway barrier". Archives of Toxicology 92 4 (2018): 1551-1561. https://doi.org/10.1007/s00204-018-2161-8.
    10.1007/s00204-018-2161-8
  11. Andrew S. Gilbert; Paula I. Seoane; Poppy Sephton-Clark; Aleksandra Bojarczuk; Richard Hotham; Emanuele Giurisato; Adil R. Sarhan; et al. "Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5". Science Advances (2017):
    10.1126/sciadv.1700898
  12. Velde, Greetje. "Genetically encoded iron-associated proteins as MRI reporters for molecular and cellular imaging.". Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology (2017): http://europepmc.org/abstract/med/28707736.
    10.1002/wnan.1482
  13. Marien E; Hillen A; Vanderhoydonc F; Swinnen JV; Vande Velde G. "Longitudinal microcomputed tomography-derived biomarkers for lung metastasis detection in a syngeneic mouse model: added value to bioluminescence imaging.". (2017): http://europepmc.org/abstract/med/27869796.
    10.1038/labinvest.2016.114
  14. Zhao C; Fernandez A; Avlonitis N; Vande Velde G; Bradley M; Read ND; Vendrell M; et al. "Searching for the Optimal Fluorophore to Label Antimicrobial Peptides.". ACS Combinatorial Science 18 11 (2016): 689-696. http://europepmc.org/abstract/med/27723293.
    10.1021/acscombsci.6b00081
  15. Vindevogel E; Baert T; VAN Hoylandt A; Verbist G; Vande Velde G; Garg AD; Agostinis P; et al. "The Use of Toll-like Receptor 4 Agonist to Reshape the Immune Signature in Ovarian Cancer.". Anticancer Research 36 11 (2016): 5781-5792. http://europepmc.org/abstract/med/27793900.
    10.21873/anticanres.11162
  16. Rangarajan JR; Vande Velde G; van Gent F; De Vloo P; Dresselaers T; Depypere M; van Kuyck K; et al. "Image-based in vivo assessment of targeting accuracy of stereotactic brain surgery in experimental rodent models.". (2016): http://europepmc.org/abstract/med/27901096.
    10.1038/srep38058
  17. Russo FM; Toelen J; Eastwood MP; Jimenez J; Miyague AH; Vande Velde G; DeKoninck P; et al. "Transplacental sildenafil rescues lung abnormalities in the rabbit model of diaphragmatic hernia.". (2016): http://europepmc.org/abstract/med/26987998.
    10.1136/thoraxjnl-2015-207949
  18. Jennifer Poelmans; Amy Hillen; Liesbeth Vanherp; Kristof Govaerts; Johan Maertens; Tom Dresselaers; Uwe Himmelreich; Katrien Lagrou; Greetje Vande Velde. "Longitudinal, in vivo assessment of invasive pulmonary aspergillosis in mice by computed tomography and magnetic resonance imaging". Laboratory Investigation 96 6 (2016): 692-704. https://doi.org/10.1038/labinvest.2016.45.
    10.1038/labinvest.2016.45
  19. Vande Velde G; Poelmans J; De Langhe E; Hillen A; Vanoirbeek J; Himmelreich U; Lories RJ. "Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume.". (2016): http://europepmc.org/abstract/med/26563390.
    10.1242/dmm.020321
  20. D'Hollander A; Mathieu E; Jans H; Vande Velde G; Stakenborg T; Van Dorpe P; Himmelreich U; Lagae L. "Development of nanostars as a biocompatible tumor contrast agent: toward in vivo SERS imaging.". (2016): http://europepmc.org/abstract/med/27536107.
    10.2147/ijn.s91340
  21. Leten C; Trekker J; Struys T; Roobrouck VD; Dresselaers T; Vande Velde G; Lambrichts I; Verfaillie CM; Himmelreich U. "Monitoring the Bystander Killing Effect of Human Multipotent Stem Cells for Treatment of Malignant Brain Tumors.". (2016): http://europepmc.org/abstract/med/26880961.
    10.1155/2016/4095072
  22. Staelens D; Liang S; Appeltans B; Van de Wouwer M; Van den Mooter G; Van Assche G; Himmelreich U; Vande Velde G. "Visualization of delayed release of compounds from pH-sensitive capsules in vitro and in vivo in a hamster model.". (2016): http://europepmc.org/abstract/med/26190202.
    10.1002/cmmi.1654
  23. Marenzana M; Vande Velde G. "Refine, reduce, replace: Imaging of fibrosis and arthritis in animal models.". (2015): http://europepmc.org/abstract/med/27107509.
    10.1016/j.berh.2016.02.001
  24. Vande Velde G; De Langhe E; Poelmans J; Bruyndonckx P; D'Agostino E; Verbeken E; Bogaerts R; Lories RJ; Himmelreich U. "Longitudinal in vivo micro-computed tomography of mouse lungs: no evidence for radiotoxicity.". (2015): http://europepmc.org/abstract/med/26024893.
    10.1152/ajplung.00098.2015
  25. Sindhwani N; Liaquat Z; Urbankova I; Vande Velde G; Feola A; Deprest J. "Immediate postoperative changes in synthetic meshes - In vivo measurements.". (2015): http://europepmc.org/abstract/med/26594782.
    10.1016/j.jmbbm.2015.10.015
  26. Verreet T; Quintens R; Van Dam D; Verslegers M; Tanori M; Casciati A; Neefs M; et al. "A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis.". (2015): http://europepmc.org/abstract/med/26029273.
    10.1186/1866-1955-7-3
  27. Leten C; Trekker J; Struys T; Dresselaers T; Gijsbers R; Vande Velde G; Lambrichts I; et al. "Assessment of bystander killing-mediated therapy of malignant brain tumors using a multimodal imaging approach.". (2015): http://europepmc.org/abstract/med/26345383.
    10.1186/s13287-015-0157-3
  28. Hollevoet K; Geukens N; Velde GV; Declerck P. "Long-term in vivo expression of trastuzumab following intramuscular electrotransfer of the encoding DNA in mice.". (2015): http://europepmc.org/abstract/PMC/PMC4547180.
    10.1186/2051-1426-3-s1-o5
  29. Vande Velde G; De Langhe E; Poelmans J; Dresselaers T; Lories RJ; Himmelreich U. "Magnetic resonance imaging for noninvasive assessment of lung fibrosis onset and progression: cross-validation and comparison of different magnetic resonance imaging protocols with micro-computed tomography and histology in the bleomycin-induced mouse model.". (2014): http://europepmc.org/abstract/med/24872004.
    10.1097/RLI.0000000000000071
  30. Caroline Vandeputte; Veerle Reumers; Sarah-Ann Aelvoet; Irina Thiry; Sylvie De Swaef; Chris Van den Haute; Jesus Pascual-Brazo; et al. "Bioluminescence imaging of stroke-induced endogenous neural stem cell response". Neurobiology of Disease 69 (2014): 144-155. http://dx.doi.org/10.1016/j.nbd.2014.05.014.
    10.1016/j.nbd.2014.05.014
  31. Greetje Vande Velde; Ellen De Langhe; Jennifer Poelmans; Tom Dresselaers; Rik J. Lories; Uwe Himmelreich. "Magnetic Resonance Imaging for Noninvasive Assessment of Lung Fibrosis Onset and Progression". Investigative Radiology 49 11 (2014): 691-698. http://dx.doi.org/10.1097/rli.0000000000000071.
    10.1097/rli.0000000000000071
  32. Lambrechts D; Roeffaers M; Goossens K; Hofkens J; Vande Velde G; Van de Putte T; Schrooten J; Van Oosterwyck H. "A causal relation between bioluminescence and oxygen to quantify the cell niche.". (2014): http://europepmc.org/abstract/med/24840204.
    10.1371/journal.pone.0097572
  33. Leten, C.; Roobrouck, V.D.; Struys, T.; Burns, T.C.; Dresselaers, T.; Vande Velde, G.; Santermans, J.; et al. "Controlling and monitoring stem cell safety in vivo in an experimental rodent model". Stem Cells 32 11 (2014): 2833-2844. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907905139&partnerID=MN8TOARS.
    10.1002/stem.1819
  34. Greetje Vande Velde; Uwe Himmelreich; Michal Neeman. "Reporter gene approaches for mapping cell fate decisions by MRI: promises and pitfalls". Contrast Media Mol. Imaging 8 6 (2013): 424-431. http://dx.doi.org/10.1002/cmmi.1590.
    10.1002/cmmi.1590
  35. Greetje Vande Velde; Sona Kucharíková; Sanne Schrevens; Uwe Himmelreich; Patrick Van Dijck. "Towards non-invasive monitoring of pathogen-host interactions during Candida albicans biofilm formation using in vivo bioluminescence". Cell Microbiol 16 1 (2013): 115-130. http://dx.doi.org/10.1111/cmi.12184.
    10.1111/cmi.12184
  36. Frederik Ceyssens; Kris van Kuyck; Greetje Vande Velde; Marleen Welkenhuysen; Linda Stappers; Bart Nuttin; Robert Puers. "Resorbable scaffold based chronic neural electrode arrays". Biomed Microdevices 15 3 (2013): 481-493. http://dx.doi.org/10.1007/s10544-013-9748-x.
    10.1007/s10544-013-9748-x
  37. Ellen De Langhe; Greetje Vande Velde; Jeroen Hostens; Uwe Himmelreich; Benoit Nemery; Frank P. Luyten; Jeroen Vanoirbeek; Rik J. Lories; Martin R. J. Kolb. "Quantification of Lung Fibrosis and Emphysema in Mice Using Automated Micro-Computed Tomography". PLoS ONE 7 8 (2012): e43123-e43123. http://dx.doi.org/10.1371/journal.pone.0043123.
    10.1371/journal.pone.0043123
  38. Greetje Vande Velde; Sébastien Couillard-Després; Ludwig Aigner; Uwe Himmelreich; Annemie van der Linden. "In situ labeling and imaging of endogenous neural stem cell proliferation and migration". WIREs Nanomed Nanobiotechnol 4 6 (2012): 663-679. http://dx.doi.org/10.1002/wnan.1192.
    10.1002/wnan.1192
  39. Greetje Vande Velde; Janaki Raman Rangarajan; Ruth Vreys; Caroline Guglielmetti; Tom Dresselaers; Marleen Verhoye; Annemie Van der Linden; et al. "Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain". NeuroImage 62 1 (2012): 367-380. http://dx.doi.org/10.1016/j.neuroimage.2012.04.040.
    10.1016/j.neuroimage.2012.04.040
  40. Stefaan J. Soenen; Simon F. De Meyer; Tom Dresselaers; Greetje Vande Velde; Inge M. Pareyn; Kevin Braeckmans; Marcel De Cuyper; Uwe Himmelreich; Karen I. Vanhoorelbeke. "MRI assessment of blood outgrowth endothelial cell homing using cationic magnetoliposomes". Biomaterials 32 17 (2011): 4140-4150. http://dx.doi.org/10.1016/j.biomaterials.2011.02.037.
    10.1016/j.biomaterials.2011.02.037
  41. Stefaan J. Soenen; Greetje Vande Velde; Ashwini Ketkar-Atre; Uwe Himmelreich; Marcel De Cuyper. "Magnetoliposomes as magnetic resonance imaging contrast agents". WIREs Nanomed Nanobiotechnol 3 2 (2011): 197-211. http://dx.doi.org/10.1002/wnan.122.
    10.1002/wnan.122
  42. Vande Velde, G.; Rangarajan, J.R.; Toelen, J.; Dresselaers, T.; Ibrahimi, A.; Krylychkina, O.; Vreys, R.; et al. "Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors". Gene Therapy 18 6 (2011): 594-605. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958248563&partnerID=MN8TOARS.
    10.1038/gt.2011.2
  43. Ruth Vreys; Greetje Vande Velde; Olga Krylychkina; Michiel Vellema; Marleen Verhoye; Jean-Pierre Timmermans; Veerle Baekelandt; Annemie Van der Linden. "MRI visualization of endogenous neural progenitor cell migration along the RMS in the adult mouse brain: Validation of various MPIO labeling strategies". NeuroImage 49 3 (2010): 2094-2103. http://dx.doi.org/10.1016/j.neuroimage.2009.10.034.
    10.1016/j.neuroimage.2009.10.034
  44. Abdelilah Ibrahimi; Greetje Vande Velde; Veerle Reumers; Jaan Toelen; Irina Thiry; Caroline Vandeputte; Sofie Vets; et al. "Highly Efficient Multicistronic Lentiviral Vectors with Peptide 2A Sequences". Human Gene Therapy 20 8 (2009): 845-860. http://dx.doi.org/10.1089/hum.2008.188.
    10.1089/hum.2008.188
  45. Vande Velde, G.; Baekelandt, V.; Dresselaers, T.; Himmelreich, U.. "Magnetic resonance imaging and spectroscopy methods for molecular imaging". Quarterly Journal of Nuclear Medicine and Molecular Imaging 53 6 (2009): 565-585. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949813574&partnerID=MN8TOARS.
Capítulo de livro
  1. Van Dyck, Katrien; Van Dijck, Patrick; Vande Velde, Greetje. "Bioluminescence Imaging to Study Mature Biofilm Formation by Candida spp. and Antifungal Activity In Vitro and In Vivo". In Methods in Molecular Biology, 127-143. Springer US, 2019.
    10.1007/978-1-4939-9940-8_9
  2. Vande Velde, Greetje; Wiehr, Stefan. "Fungal Imaging". In Imaging Infections, 173-183. Springer International Publishing, 2017.
    Publicado • 10.1007/978-3-319-54592-9_7
  3. Velde, Greetje Vande; Kucharíková, Sona; Van Dijck, Patrick; Himmelreich, Uwe. "Bioluminescence Imaging of Fungal Biofilm Development in Live Animals". In Methods in Molecular Biology, 153-167. Humana Press, 2013.
    10.1007/978-1-62703-718-1_13
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2014 - 2018 Multimodal imaging to study infection and treatment response in a mouse model of invasive pulmonary aspergillosis
Coorientador
Katholieke Universiteit Leuven Groep Biomedische Wetenschappen, Bélgica

Arbitragem científica em conferência

Nome da conferência Local da conferência
2015 - 2018 European Molecular Imaging Meeting European Society for Molecular Imaging

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2012 - 2012 International Society for Magnetic Resonance in Medicine Workshop MRI-based Cell Tracking

Membro de associação

Nome da associação Tipo de participação
2019 - Atual Belgische Vereniging voor Pneumologie, BVP
2019 - Atual EuroScience
2017 - Atual European Respiratory Society, ERS
2015 - Atual Women in Molecular Imaging Network
2015 - Atual America Thoracic Society
2012 - Atual European Society for Molecular Imaging (ESMI)
2012 - Atual Belgian Molecular Imaging Community, BMIC Founding Member (Vice-President)

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2011 - Atual International Society for Magnetic Resonance in Medicine (ISMRM) Benelux Chapter 2011 Annual Meeting
Coordenador
Distinções

Prémio

2016 Industry Selected Abstract for Best Clinical Paper
2015 Women in Molecular Imaging Network Scholar Award, WMIC
2015 Best Research & Technology Exhibitor Selected Award
2014 Best Oral Presentation
2012 Best Oral Presentation Award
Bruker microCT, Bélgica