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Hugo Osorio graduated in Biochemistry (1999) and holds a PhD in Biomedical Sciences (2004) from the University of Porto. His research focuses on the development and application of mass-spectrometry based proteomics approaches in biomedicine with a focus on cancer proteomics and glycosylation profiling. Hugo Osorio is the Head of the i3S Proteomics Scientific Platform and Professor at University of Porto. He is member of the board of the Portuguese Proteomics Association – ProCura and manages the i3S node of the Portuguese Mass Spectrometry Network- RNEM integrated in the FCT Research Infrastructures RoadMap. He organizes and participates in pre and postgraduate mass spectrometry and proteomics courses. As of February 2025, Hugo Osorio has 101 publications in international peer-reviewed journals and three book chapters. His research work has over 3900 citations and with an h-index of 27 (Scopus).
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Hugo Alexandre Carvalho Pinheiro Osório

Nomes de citação

  • Osorio, Hugo

Identificadores de autor

Ciência ID
211F-9A6D-2886
ORCID iD
0000-0002-6362-8255
Scopus Author Id
6601979151

Endereços de correio eletrónico

  • hosorio@i3s.up.pt (Profissional)

Moradas

  • i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135, Porto, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B2)
Formação
Grau Classificação
2004/12/17
Concluído
 Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Role of oxidative stress in Saccharomyces cerevisiae nucleotide metabolism" (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade
1999/12/17
Concluído
 Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/10/01 - Atual Investigador (Investigação) Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
2006/10/01 - Atual Investigador (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/02/23 - 2023/07/31 Professor Auxiliar Convidado (Docente Universitário) Universidade do Porto Faculdade de Ciências, Portugal
2015/04/07 - 2023/01/01 Professor Auxiliar Convidado (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2022/01/01 - 2026/05/01 NEUROSENSE - NEUROendocrine SENSor for Sudden Unexpected Death in Epilepsy (SUDEP) prediction and prevention
101047131
Investigador
Universidade do Porto Instituto de Investigacao e Inovacao em Saude, Portugal
 European Commission
Em curso
2016/01 - 2018/12 CELLULAR GLYCOENGINEERING FOR EVALUATION OF POST-TRANSLATIONAL MODIFICATIONS OF RECEPTORS IN CANCER: THERAGNOSTIC APPLICATIONS
Provided by PTCRIS: 139174
 Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2023/03/01 - 2026/02/28 Targeting a ‘toolbox’ of human microbiome O-Glycan-Selective proteins towards new approaches in cancer research
2022.06104.PTDC
10.54499/2022.06104.PTDC
Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2024/12/31 GLYCOTARGET. A NEW FRONTIER IN EXTRACELLULAR VESICLE-MEDIATED CANCER IMMUNOMODULATION
PTDC/MEC-ONC/0491/2021
Investigador
Fundação para a Ciência e a Tecnologia
2022/01/01 - 2024/12/31 COoperative Mechanical couPling of adherens junctions and focaL adhesIons supporting breast CancEr progression
PTDC/BIA-BFS/0812/2021
Investigador
Fundação para a Ciência e a Tecnologia
2022/01/01 - 2024/12/31 SweetKiller: Monosaccharide analogues as novel therapeutic agents to block glycan-driven cancer cell metastasis
PTDC/MED-QUI/2335/2021
Investigador
Fundação para a Ciência e a Tecnologia
2023/01/01 - 2024/06/30 Understand the contribution of Extracellular Vesicles for the establishment of a pancreatic cancer METastatic niche at the liver – the EVMet
2022.01036.PTDC
Investigador
Fundação para a Ciência e a Tecnologia
2022/01/01 - 2023/06/30 Exploring glycans as novel players in tumor-adipose tissue transdifferentiation and cancer cachexia
EXPL/MED-ONC/1001/2021
Investigador
Fundação para a Ciência e a Tecnologia
2022/01/01 - 2023/06/30 Glycan-defined organoids as gastric cancer avatars for patient stratification and prediction of therapeutic response
EXPL/BTM-ORG/1450/2021
Investigador
Fundação para a Ciência e a Tecnologia
2018/07/15 - 2022/01/15 Molecular strategies to be applied in the depuration of commercial bivalves for elimination of toxic compounds
PTDC/ASP-PES/31762/2017
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Português do Mar e da Atmosfera, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/15 - 2022/01/14 Predicting patients' response to liposomal anticancer drugs: focusing on LRP1B endocytic activity
PTDC/MEC-ONC/31520/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/10/01 - 2021/09/30 Advances in MUC1 Glycan Cancer Antigens: From structure to function in the fight against cancer
PTDC/BIA-MIB/31028/2017
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/10/01 - 2021/09/30 Occult Hepatitis C in Different Clinical Settings: Detection, Characterization and Diagnostic Tools
PTDC/SAU-SER/30788/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

International Iberian Nanotechnology Laboratory, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Circulating tumor Extracellular Vesicles for minimally-invasive detection of Minimal Residual Disease in Acute Myeloid Leukemia patients
PTDC/MEC-HEM/30457/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Centro Hospitalar Universitário de São João, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Identification of Novel GlycoSpecific Drugs to Tackle Cancer Cell Metastasis
PTDC/MED-QUI/29780/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Meet the ExoNet: Targeting the Exosomes Network in Pancreatic Cancer
PTDC/MEC-GAS/32189/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Microbiome-derived metabolites as new gastric cancer biomarkers
PTDC/MED-OUT/32532/2017
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Stroke in translation: Biomarkers for diagnosis and management of acute ischemic stroke
PTDC/MEC-NEU/31674/2017
Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Centro Hospitalar Universitário do Porto EPE, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/01 - 2021/06/30 Thymus regeneration: Development of a high-content discovery program to identify new bioactive compounds and molecular determinants that induce Foxn1 expression in thymic epithelial cells.
PTDC/MED-IMU/29129/2017
Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2012/10/01 - 2015/12/31 Mucin MUC16 - CA125 cancer biomarker - biological functions and development of new biomarker assays
PTDC/SAU-ONC/117216/2010
117216
Provided by PTCRIS: 117216
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2012/03/01 - 2015/06/30 Unravelling a new Helicobacter pylori virulence factor involved in tight junction dysfunction
PTDC/BIA-MIC/116890/2010
Provided by PTCRIS: 116890
116890
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009/01/01 - 2012/03/31 Early detection of cancer using serum biomarkers based on aberrant post-translational modifications of O-glycoproteins, O-PTM-Biomarkers.
PIC/IC/82716/2007
Provided by PTCRIS: 82716
82716
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2000/07/01 - 2004/06/30 METABOLISMO DE NUCLEÓTIDOS E DINUCLEÓSIDOS POLIFOSFATOS EM SITUAÇÕES DE STRESS OXIDATIVO.
SFRH/BD/1477/2000
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Pereira, Clara; Pereira, Andreia T.; Osório, Hugo; Moradas-Ferreira, Pedro; Costa, Vitor. "The Sit4p phosphatase controls mitochondrial function and lifespan by regulating the phosphorylation of the ATP synthase beta subunit Atp2p". 2018.
    10.1016/j.freeradbiomed.2018.04.271
Artigo em revista
  1. Silva, Catarina S.; Casanova, Marta R.; Ferreirinha, Pedro; da Silva Morais, Alain; Osório, Hugo; Lima, Ana C.; Fangueiro, Joana F.; et al. "The effect of conditioned medium from human amniotic membrane-derived mesenchymal stem cells on thymus involution". Life Sciences 362 (2025): 123366. https://doi.org/10.1016/j.lfs.2024.123366.
    10.1016/j.lfs.2024.123366
  2. Gonçalves, Bruna; Pires, Diana Priscila; Fernandes, Liliana; Pacheco, Miguel; Ferreira, Tiago; Osório, Hugo; Soares, Ana Raquel; Henriques, Mariana; Silva, Sónia. "Biofilm matrix regulation by Candida glabrata Zap1 under acidic conditions: transcriptomic and proteomic analyses". Microbiology Spectrum 12 12 (2024): https://doi.org/10.1128/spectrum.01201-24.
    10.1128/spectrum.01201-24
  3. Hugo Girão; Joana Macário-Monteiro; Ana C. Figueiredo; Ricardo Silva e Sousa; Elena Doria; Vladimir Demidov; Hugo Osório; et al. "a-tubulin detyrosination fine-tunes kinetochore-microtubule attachments". Nature Communications (2024): https://doi.org/10.1038/s41467-024-54155-8.
    10.1038/s41467-024-54155-8
  4. Chagas, Ana Carolina S.; Ribeiro, David M.; Osório, Hugo; Abreu, Ana A.P.; Okino, Cintia H.; Niciura, Simone C.M.; Amarante, Alessandro F.T.; et al. "Molecular signatures of Haemonchus contortus infection in sheep: A comparative serum proteomic study on susceptible and resistant sheep breeds". Veterinary Parasitology 331 (2024): 110280. https://doi.org/10.1016/j.vetpar.2024.110280.
    10.1016/j.vetpar.2024.110280
  5. Almeida-Nunes, Diana Luísa; Nunes, Mariana; Osório, Hugo; Ferreira, Verónica; Lobo, Cláudia; Monteiro, Paula; Abreu, Miguel Henriques; et al. "Ovarian cancer ascites proteomic profile reflects metabolic changes during disease progression". Biochemistry and Biophysics Reports 39 (2024): 101755. https://doi.org/10.1016/j.bbrep.2024.101755.
    10.1016/j.bbrep.2024.101755
  6. Francisca Diniz; Sofia Lamas; Hugo Osório; Paulo Aguiar; Daniela Freitas; Fátima Gärtner; Bruno Sarmento; Celso A. Reis; Joana Gomes. "Nanoparticles targeting Sialyl-Tn for efficient tyrosine kinase inhibitor delivery in gastric cancer". Acta Biomaterialia (2023): https://doi.org/10.1016/j.actbio.2023.08.014.
    10.1016/j.actbio.2023.08.014
  7. Joana Peixoto; Catarina Príncipe; Ana Pestana; Hugo Osório; Marta Teixeira Pinto; Hugo Prazeres; Paula Soares; Raquel T. Lima. "Using a Dual CRISPR/Cas9 Approach to Gain Insight into the Role of LRP1B in Glioblastoma". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241411285.
    10.3390/ijms241411285
  8. Celina São José; Carla Pereira; Marta Ferreira; Ana André; Hugo Osório; Irene Gullo; Fátima Carneiro; Carla Oliveira. "3D Chromatin Architecture Re-Wiring at the CDH3/CDH1 Loci Contributes to E-Cadherin to P-Cadherin Expression Switch in Gastric Cancer". Biology (2023): https://doi.org/10.3390/biology12060803.
    10.3390/biology12060803
  9. Juliana Poças; Catarina Marques; Catarina Gomes; Andreia Hanada Otake; Filipe Pinto; Mariana Ferreira; Tiago Silva; et al. "Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival". Proceedings of the National Academy of Sciences 120 (2023):
    Acesso aberto • 10.1073/pnas.2214853120
  10. Sofia Esteves; Clara Lima; Inês Costa; Hugo Osório; Carmen Fernandez-Becerra; Nuno Santarém; Anabela Cordeiro-da-Silva. "Characterization and Proteomic Analysis of Plasma EVs Recovered from Healthy and Diseased Dogs with Canine Leishmaniosis". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24065490.
    10.3390/ijms24065490
  11. Ana Teresa Pinto; Ana Beatriz Machado; Hugo Osório; Marta Laranjeiro Pinto; Rui Vitorino; Gonçalo Justino; Cátia Santa; et al. "Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression". Cancers (2022): https://doi.org/10.3390/cancers15010270.
    10.3390/cancers15010270
  12. Francisca Diniz; Maria Azevedo; Flávia Sousa; Hugo Osório; Diana Campos; Paula Sampaio; Joana Gomes; Bruno Sarmento; Celso A. Reis. "Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions". Materials Today Bio 16 (2022): 100417-100417. http://dx.doi.org/10.1016/j.mtbio.2022.100417.
    10.1016/j.mtbio.2022.100417
  13. José C. Soares; Hugo Osório; Manuela Pintado; Marta W. Vasconcelos. "Effect of the Interaction between Elevated Carbon Dioxide and Iron Limitation on Proteomic Profiling of Soybean". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232113632.
    10.3390/ijms232113632
  14. Maria João Leal Romeu; Dany Domínguez Pérez; Daniela Almeida; João Morais; Mário J. Araújo; Hugo Osório; Alexandre Campos; Vítor Vasconcelos; Filipe Mergulhão. "Hydrodynamic conditions affect the proteomic profile of marine biofilms formed by filamentous cyanobacterium". npj Biofilms and Microbiomes 8 1 (2022): http://dx.doi.org/10.1038/s41522-022-00340-w.
    10.1038/s41522-022-00340-w
  15. Diogo Coelho; David Ribeiro; Hugo Osório; André Martinho de Almeida; José António Mestre Prates. "Integrated Omics analysis of pig muscle metabolism under the effects of dietary Chlorella vulgaris and exogenous enzymes". Scientific Reports 12 1 (2022): http://dx.doi.org/10.1038/s41598-022-21466-z.
    10.1038/s41598-022-21466-z
  16. Sónia Ribeiro; Ana Rita Simões; Filipe Rocha; Inês Sofia Vala; Ana Teresa Pinto; Augusto Ministro; Esmeralda Poli; et al. "Molecular Changes In Cardiac Tissue As A New Marker To Predict Cardiac Dysfunction Induced By Radiotherapy". Frontiers in Oncology 12 (2022): http://dx.doi.org/10.3389/fonc.2022.945521.
    10.3389/fonc.2022.945521
  17. Ana M. Moreira; Rui M. Ferreira; Patrícia Carneiro; Joana Figueiredo; Hugo Osório; José Barbosa; John Preto; et al. "Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression". Frontiers in Molecular Biosciences 9 (2022): http://dx.doi.org/10.3389/fmolb.2022.818552.
    10.3389/fmolb.2022.818552
  18. David M. Ribeiro; Diogo Coelho; Hugo Osório; Cátia Martins; João P. Bengala Freire; João Almeida; Olga Moreira; André M. Almeida; José A.M. Prates. "Effect of dietary incorporation of Chlorella vulgaris and CAZyme supplementation on the hepatic proteome of finishing pigs". Journal of Proteomics 256 (2022): 104504-104504. http://dx.doi.org/10.1016/j.jprot.2022.104504.
    10.1016/j.jprot.2022.104504
  19. Ruivo, Carolina F; Bastos, Nuno; Adem, Barbara; Batista, Ines; Duraes, Cecilia; Melo, Carlos A; Castaldo, Stephanie A; et al. "Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression". Gut (2022): gutjnl-2021. http://dx.doi.org/10.1136/gutjnl-2021-324994.
    Aceite para publicação • 10.1136/gutjnl-2021-324994
  20. Ana Graça; Manuel Gomez-Florit; Hugo Osório; M. T. Rodrigues; Rui M.A. Domingues; Rui L. Reis; ME Gomes. "Controlling the fate of regenerative cells with engineered platelet-derived extracellular vesicles". Nanoscale 14 17 (2022): 6543-6556. http://dx.doi.org/10.1039/d1nr08108j.
    10.1039/d1nr08108j
  21. Marta R. Casanova; Hugo Osório; Rui L. Reis; Albino Martins; Nuno M. Neves. "Chondrogenic differentiation induced by extracellular vesicles bound to a nanofibrous substrate". npj Regenerative Medicine (2021): https://doi.org/10.1038/s41536-021-00190-8.
    10.1038/s41536-021-00190-8
  22. M.J. Romeu; D. Domínguez-Pérez; D. Almeida; J. Morais; M.J. Araújo; H. Osório; A. Campos; V. Vasconcelos; F.J. Mergulhão. "Quantitative proteomic analysis of marine biofilms formed by filamentous cyanobacterium". Environmental Research 201 (2021): 111566-111566. https://doi.org/10.1016/j.envres.2021.111566.
    10.1016/j.envres.2021.111566
  23. Cláudia M. Botelho; Pedro Ferreira-Santos; Duarte Toubarro; Hugo Dinis; Hugo Osório; Augusto Costa-Barbosa; Paula Sampaio; Nelson Simões; José A. Teixeira. "Chicken Feather Keratin Peptides for the Control of Keratinocyte Migration". Applied Sciences 11 15 (2021): 6779-6779. https://doi.org/10.3390/app11156779.
    10.3390/app11156779
  24. Melo, Joana; Pinto, Vanessa; Fernandes, Tânia; Malheiro, Ana R.; Osório, Hugo; Figueiredo, Ceu; Leite, Marina. "Isolation Method and Characterization of Outer Membranes Vesicles of Helicobacter pylori Grown in a Chemically Defined Medium". Frontiers in Microbiology 12 (2021): http://dx.doi.org/10.3389/fmicb.2021.654193.
    10.3389/fmicb.2021.654193
  25. José A M Prates; João P. B. Freire; André M. de Almeida; Cátia Martins; Ribeiro, D. M.; Hugo Osorio; Mário Pinho; et al. "Influence of Dietary Supplementation with an Amino Acid Mixture on Inflammatory Markers, Immune Status and Serum Proteome in LPS-Challenged Weaned Piglets". Animals (2021): https://www.mdpi.com/2076-2615/11/4/1143.
    10.3390/ani11041143
  26. Osorio, Hugo. "Revealing Candida glabrata biofilm matrix proteome: global characterization and pH response.". The Biochemical journal (2021): https://doi.org/10.1042/BCJ20200844.
    10.1042/bcj20200844
  27. Osorio, Hugo. "Particulate kidney extracellular matrix: bioactivity and proteomic analysis of a novel scaffold from porcine origin.". Biomaterials science (2021): https://doi.org/10.1039/d0bm01272f.
    10.1039/d0bm01272f
  28. Miguel S. Marques; Ana C. Costa; Hugo Osório; Marta L. Pinto; Sandra Relvas; Mário Dinis-Ribeiro; Fátima Carneiro; Marina Leite; Ceu Figueiredo. "Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity". Gut Microbes (2021): https://doi.org/10.1080/19490976.2021.1921928.
    10.1080/19490976.2021.1921928
  29. Hugo Osorio; Cátia Silva; Marta Ferreira; Irene Gullo; Valdemar Maximo; Rita Barros; Fernando Mendonça; Oliveira C; Carneiro F. "Proteomics Analysis of Gastric Cancer Patients with Diabetes Mellitus". Journal of Clinical Medicine (2021): https://www.mdpi.com/2077-0383/10/3/407.
    10.3390/jcm10030407
  30. Cristina Valentim-Coelho; Fátima Vaz; Antunes, M.; Sofia Neves; Inês L. Martins; Hugo Osorio; Amélia Feliciano; et al. "Redox–Oligomeric State of Peroxiredoxin-2 and Glyceraldehyde-3-Phosphate Dehydrogenase in Obstructive Sleep Apnea Red Blood Cells under Positive Airway Pressure Therapy". Antioxidants (2020): https://www.mdpi.com/2076-3921/9/12/1184.
    10.3390/antiox9121184
  31. Daniela Almeida; Dany Domínguez Pérez; Ana Matos; Agüero-Chapin G; Hugo Osorio; Vitor Vasconcelos; Alexandre Campos; Agostinho Antunes. "Putative Antimicrobial Peptides of the Posterior Salivary Glands from the Cephalopod Octopus vulgaris Revealed by Exploring a Composite Protein Database". Antibiotics (2020): https://www.mdpi.com/2079-6382/9/11/757.
    10.3390/antibiotics9110757
  32. Alexandre Campos; Marisa Freitas; André M. de Almeida; José Carlos Martins; Dany Domínguez Pérez; Hugo Osorio; Vitor Vasconcelos; Pedro Reis Costa. "OMICs Approaches in Diarrhetic Shellfish Toxins Research". Toxins (2020): https://www.mdpi.com/2072-6651/12/8/493.
    10.3390/toxins12080493
  33. Moura, Sara Reis; Bras, Joao Paulo; Freitas, Jaime; Osório, Hugo; Barbosa, Mario Adolfo; Santos, Susana Gomes; Almeida, Maria Ines. "miR-99a in bone homeostasis: Regulating osteogenic lineage commitment and osteoclast differentiation". Bone 134 (2020): 115303. http://dx.doi.org/10.1016/j.bone.2020.115303.
    10.1016/j.bone.2020.115303
  34. Barreto, A.; Carvalho, A.; Campos, A.; Osório, H.; Pinto, E.; Almeida, A.; Trindade, T.; et al. "Effects of gold nanoparticles in gilthead seabream—A proteomic approach". Aquatic Toxicology 221 (2020): 105445. http://dx.doi.org/10.1016/j.aquatox.2020.105445.
    10.1016/j.aquatox.2020.105445
  35. da Fonseca, R.R.; Couto, A.; Machado, A.M.; Brejova, B.; Albertin, C.B.; Silva, F.; Gardner, P.; et al. "A draft genome sequence of the elusive giant squid, Architeuthis dux". GigaScience 9 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85077940907&partnerID=MN8TOARS.
    10.1093/gigascience/giz152
  36. Mendes, Bárbara B.; Gómez-Florit, Manuel; Osório, Hugo; Vilaça, Adriana; Domingues, Rui M. A.; Reis, Rui L.; Gomes, Manuela E.. "Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response". Chemical Communications 56 50 (2020): 6882-6885. http://dx.doi.org/10.1039/d0cc01850c.
    10.1039/d0cc01850c
  37. Elisabete Martins; Joana Urbano; Sérgio Leite; Adriana Pinto; Raquel Garcia; Rui Bergantim; Pedro Rodrigues-Pereira; et al. "Cardiac Amyloidosis Associated with Apolipoprotein A-IV Deposition Diagnosed by Mass Spectrometry-Based Proteomic Analysis". Eur J Case Rep Intern Med 6 12 (2019): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936921/.
    Acesso aberto • Publicado • 10.12890/2019_001237
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  95. Osorio, H.; Carvalho, E.; Del Valle, M.; Günther Sillero, M.A.; Moradas-Ferreira, P.; Sillero, A.. "H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae: An experimental and theoretical approach". European Journal of Biochemistry 270 7 (2003): 1578-1589. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037394045&partnerID=MN8TOARS.
    10.1046/j.1432-1033.2003.03529.x
  96. Günther Sillero, M.A.; De Diego, A.; Osorio, H.; Sillero, A.. "Dinucleoside polyphosphates stimulate the primer independent synthesis of poly(A) catalyzed by yeast poly(A) polymerase". European Journal of Biochemistry 269 21 (2002): 5323-5329. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036428538&partnerID=MN8TOARS.
    10.1046/j.1432-1033.2002.03253.x
Capítulo de livro
  1. Osório, Hugo; de Almeida, André M.; Campos, Alexandre. "Sample Preparation for 2DE Using Samples of Animal Origin". In Proteomics in Domestic Animals: from Farm to Systems Biology, 37-53. Springer International Publishing, 2018.
    10.1007/978-3-319-69682-9_4
  2. Rodrigues, Pedro M.; Schrama, Denise; Campos, Alexandre; Osório, Hugo; Freitas, Marisa. "Applications of Proteomics in Aquaculture". In Agricultural Proteomics Volume 1, 175-209. Springer International Publishing, 2016.
    10.1007/978-3-319-43275-5_10
  3. Osório, Hugo; Reis, Celso A.. "Mass Spectrometry Methods for Studying Glycosylation in Cancer". In Mass Spectrometry Data Analysis in Proteomics, 301-316. Humana Press, 2013.
    10.1007/978-1-62703-392-3_13
Poster em conferência
  1. Figueiredo, Gonçalo; Osorio, Hugo; Marta Mendes; Mendo, Sónia. "Complete genome of Pedobacter lusitanus NL19: a comprehensive genomic analysis". Trabalho apresentado em Microbiotec'23, 2023.
  2. Girão, Hugo; Macário-Monteiro, Joana; Ricardo Silva e Sousa; Ana C. Figueiredo; Elena Doria; Osorio, Hugo; Patrick Meraldi; Ekaterina L. Grishchuk; Maiato, Helder. Autor correspondente: Maiato, Helder. "Kinetochores read detyrosinated tubulin to sustain microtubule attachments". Trabalho apresentado em 2023 ASCB Meeting - Boston, EUA, 2023.
  3. Diana Luísa Almeida-Nunes; Nunes M; Osorio, Hugo; Verónica Ferreira; Cláudia Lobo; Paula Monteiro; Miguel Henriques Abreu; et al. "Análise proteómica de ascites de pacientes com cancro do ovário reflete a modificação metabólica no microambiente tumoral durante a quimioterapia". Trabalho apresentado em 8º Curso Avançado de Ginecologia Oncológica, 2023.
  4. Ribeiro, Sónia; Pereira, Ana Rita S.; Rocha, Filipe; Vala, Inês Sofia; Pinto, Ana Teresa; Ministro, Augusto; Poli, Esmeralda; et al. Autor correspondente: Santos, Susana Constantino Rosa. "Cardiac tissue remodelling induced by ionizing radiation in a dosedependent manner is an early predictor of subclinical cardiac dysfunction.". Trabalho apresentado em European Radiation Protection Week 2022, 2022.
  5. Brandão, Catarina; Nunes, Diana; Nunes, Mariana; Osório, Hugo; Ricardo, Sara. "Development of an In Silico Approach to Identify Key Proteins Involved in the Peritoneal Dissemination of Ovarian Cancer". Trabalho apresentado em VII Jornadas da Bioquímica, 2022.
  6. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Autor correspondente: Maria José Oliveira. "Unveil the biochemical and biomechanical properties of colorectal cancer patients-derived tissues from different colon locations". Trabalho apresentado em The Structural Microenvironment: Breaking down the walls of cancer (EACR), 2022.
  7. Marques, Sara; Osorio, Hugo; Salta, S; José Pedro Sequeira; Matas, Isabel María; Simão, Adélia ; Madaleno, João; Carvalho, Armando; Silva, Eliane. "Occult hepatitis C Infection: HCV/OCI Infection and Replication in MDBK and Huh7.5 cell line cultures.". Trabalho apresentado em 31st Annual Meeting of the Society for Virology., 2022.
  8. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Autor correspondente: Maria José Oliveira. "Dissecting the biochemical and biomechanical properties of colorectal cancer extracellular matrix". Trabalho apresentado em II ASPIC-ASEICA International meeting ¿ Current trends in precision medicine in cancer, 2021.
  9. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Autor correspondente: Maria José Oliveira. "Dissecting the properties of colorectal cancer patients-derived extracellular matrix". Trabalho apresentado em Goodbye Flat Biology: Next generation cancer models, 2021.
  10. Ângela Marques-Magalhães; Marta Laranjeiro Pinto; Cruz, Tânia; Caldeira, Joana; Osorio, Hugo; Pedro Amoroso Canão; Elisabete Rios; et al. Autor correspondente: Maria José Oliveira. "Cancro colorrectal: propriedades bioquímicas e biomecânicas da matriz extracelular de pacientes". Trabalho apresentado em 3º Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO), 2021.
  11. Patrícia C. Henriques; Osorio, Hugo; Fernão D. Magalhães; Gonçalves, Inês de Castro. "How graphene surface features impact plasma protein adsorption: the power of proteomics". Trabalho apresentado em 31st Conference of the European Society for Biomaterials (ESB), 2021.
  12. Malta, Mariana D.; Osorio, Hugo; Guttmann-Gruber, Christina; Kocher, Thomas; Carvalho, Andreia F.; Cerqueira, Mariana T.; Marques, Alexandra P.. "Extracellular Matrix Distinct Signature Among Dystrophic Epidermolysis Bullosa Variants". Trabalho apresentado em 1st Global Congress on Epidermolysis Bullosa, 2020.
    10.2340/00015555-3586
  13. Pereira. Clara; Martins, Telma; Pereira, Andreia T.; Osório, Hugo; Moradas-Ferreira, Pedro; Costa, Vítor. "Phosphoproteomic screening identifies ATP synthase subunit beta as a target of the yeast type 2A-like protein phosphatase Sit4p". Trabalho apresentado em MitoPorto ¿ Advances in mitochondrial research, 2017.
  14. Pereira, Clara; Pereira, Andreia T.; Osório, Hugo; Moradas-Ferreira, Pedro; Costa, Vítor. "Identification of the F1Fo ATP synthase ß subunit as a target of the phosphatase Sit4p, impacting mitochondrial function and longevity in yeast". Trabalho apresentado em XIX Congresso Nacional de Bioquímica, 2016.
  15. Pereira, Clara; Pereira, Andreia T.; Osório, Hugo; Moradas-Ferreira, Pedro; Costa, Vítor. "Phosphoproteome analysis to elucidate the role of the ceramide-activated protein phosphatase Sit4p in mitochondrial function and lifespan in yeast". Trabalho apresentado em XVIII Congresso Nacional de Bioquímica, 2014.
  16. Pereira, Clara; Pereira, Andreia; Osório, Hugo; Moradas-Ferreira, Pedro; Costa, Vítor. "Identification of the F1Fo ATP synthase complex ß subunit as a potential target for the phosphatase Sit4p, impacting lifespan extension in yeast". Trabalho apresentado em 18th European BioEnergetics Conference, 2014.
  17. Pereira, Clara; Pereira, Andreia T.; Osório, Hugo; Moradas-Ferreira, Pedro; Costa, Vítor. "Using phosphoproteomics to elucidate the role of the phosphatase Sit4p in mitochondrial function and lifespan yeast". Trabalho apresentado em IJUP14-7º Encontro de Investigação Jovem da Universidade do Porto, 2014.
  18. Barbosa, António Daniel; Osório, Hugo; Alves, Mariana; Amorim, Maria Amélia; Moradas-Ferreira, Pedro; Costa, Vítor. "ISC1-dependent regulation of the cell integrity pathway is required for oxidative stress resistance and chronological lifespan in yeast". Trabalho apresentado em Annual meeting of the Coordination Action LINK-AGE - Third topic research groups meeting, 2009.
  19. Barbosa, António Daniel; Osório, Hugo; Alves, Mariana; Amorim, Maria Amélia; Moradas-Ferreira, Pedro; Costa, Vítor. "The role of Sit4 in Isc1-dependent sphingolipid signalling during oxidative stress and chronological ageing in yeast". Trabalho apresentado em 24th International Conference on Yeast Genetics and Molecular Biology, 2009.
  20. Barbosa, António Daniel; Osório, Hugo; Alves, Mariana; Amorim, Maria Amélia; Moradas-Ferreira, Pedro; Costa, Vítor. "Chronological ageing and oxidative stress in Saccharomyces cerevisiae: the role of Sit4 in Isc1-dependent sphingolipid signalling". Trabalho apresentado em MARK-AGE/LINK-AGE joint summer school "From molecular mechanisms to biomarkers of human ageing", 2009.
  21. Barbosa, António Daniel; Osório, Hugo; Alves, Mariana; Amorim, Maria Amélia; Moradas-Ferreira, Pedro; Costa, Vítor. "ISC1-dependent sphingolipid signalling during oxidative stress and chronological ageing in yeast". Trabalho apresentado em XVI Congresso Nacional de Bioquímica, 2008.
Resumo em conferência
  1. Felício, Daniela; Osorio, Hugo; Pereira, Maria da Conceição; Sequeiros, Jorge; Lemos, Carolina; Santos, Mariana. "The potential impact of TTBK2 missense variants in SCA11: in silico analysis and a phosphoproteome study". Trabalho apresentado em 56th European Society of Human Genetics (ESHG) Conference, Glasgow, 2024.
    Aceite para publicação
  2. Pereira, Clara; Pereira, Andreia; Pereira, Joana; Osório, Hugo; Moradas-Ferreira, Pedro; Costa, Vítor. "Identification of the F1Fo ATP synthase complex ß Subunit as a potential target for the phosphatase Sit4p, impacting on mitochondrial function in yeast". Trabalho apresentado em 27th International Conference on Yeast Genetics and Molecular Biology, Yeast, Levico Terme (Trento), 2015.
    Publicado

Propriedade Intelectual

Patente
  1. Gertrude Thompson; Silva, Eliane; Marques, Sara; Osorio, Hugo; Carvalheira, Julio Gil Vale. 2013. "HCV homolog fragments, cell-lines and applications thereof.". Portugal.
    Expirada
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019/10/01 - 2020/12/11 Multiple Testing in Proteomics
Coorientador
 Master in Bioinformatics & Computational Biology (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2009 - 2013 Discovery of Novel Biomarkers in Gastric Cancer based on Post-translational Modifications of Glycoproteins
Coorientador
Universidade do Porto Faculdade de Medicina, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2021/02/26 Molecular effects of metals and ionizing radiation on cells exposed in vitro to an effluent from a uranium mine
Arguente principal
 Letícia Isabel Rato Vieira (Mestrado)
Universidade de Aveiro, Portugal
2020/01/28 Deepening the study of the two-peptide lantibiotic lichenicidin: bioengineering, toxicity and mode of action.
Vogal
 Joana Cristina Pacheco Barbosa (Doutoramento)
Universidade de Aveiro, Portugal
2015/10/16 A glycoproteomics discovery strategy for gastric cancer biomarkers
Vogal
 Diana Campos (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

Membro de associação

Nome da associação Tipo de participação
2017/01/01 - Atual Portuguese Mass Spectrometry Network i3S Node Director
2009/01/01 - Atual Portuguese Proteomics Association - Procura Board Member