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Jose Fernando Reyes Benítez is Area Head of the Chemistry Department at Fundación MEDINA, where he leads a group of scientists working on isolation and structural characterization of bioactive metabolites from microbial sources, including actinomycetes and fungi. He received a Ph. D. in Organic Chemistry from the University of Granada (Spain) in 1995. In 1997-98, he carried out an 18-month post-doctoral stage with the late Prof. Chris Abell at the University of Cambridge (UK), focused on the synthesis of potential inhibitors of enzymes of the shikimate and pantothenate pathways. Over the last 30 years, he has worked on the isolation and structural elucidation of bioactive natural products from several sources and for different companies and institutions, including Smithkline Beecham, PharmaMar and Fundación MEDINA. His work at PharmaMar during the period 2000-2010 was mainly focused on the isolation of anticancer metabolites from marine organisms, and one of the compounds isolated by his team (PM-184) is currently licensed to Seattle Genetics for the development of Antibody Drug Conjugates to combat cancer. Additionally, the antibiotic Medinamycin, discovered by his team at MEDINA has been licensed to the US company Prokaryotics Inc.. He has co-authored over 200 scientific publications in the field of natural products chemistry and is co-inventor of 15 international and 5 national patents, all of them on bioactive natural products. He is member of the editorial board of Marine Drugs, Review Editor of Frontiers in Marine Biotechnology, and serves regularly as reviewer of several journals in the field of natural products. He has participated as WP Leader in several FP7, H2020 and Horizon Europe projects focused on Marine Biotechnology (PharmaSea, Ocean Medicines, MarPipe, COMBO, MARBLES, EUREMAP) and has been Management Committee Member representing Spain of the Cost Action CA18238 - European transdisciplinary networking platform for marine biotechnology (https://www.ocean4biotech.eu/ ).
Identificação

Identificação pessoal

Nome completo
Jose Fernando Reyes Benítez

Nomes de citação

  • Reyes, Fernando
  • Reyes Benitez, José Fernando

Identificadores de autor

Ciência ID
2214-59EC-F09D
ORCID iD
0000-0003-1607-5106
Google Scholar ID
https://scholar.google.es/citations?user=hGKbUhIAAAAJ&hl=es
Researcher Id
G-4027-2013
Scopus Author Id
57447965900

Domínios de atuação

  • Ciências Exatas - Química - Química Orgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano (Idioma materno)
Formação
Grau Classificação
1990/01/09 - 1995/04/21
Concluído
Doctorado en Química Orgánica y Farmacéutica (Doutoramento)
Universidad de Granada, Espanha
"Estudio de la producción y biosíntesis de giberelinas en Gibberella fujikuroi" (TESE/DISSERTAÇÃO)
1985/10/01 - 1990/07
Concluído
Licenciado en Ciencias Químicas- Especialidad en Química Orgánica (Licenciatura)
Universidad de Granada, Espanha
"Alquilresorcinoles de Ononis Viscosa L." (TESE/DISSERTAÇÃO)
Percurso profissional

Cargos e Funções

Categoria Profissional
Instituição de acolhimento
Empregador
2010/09/01 - Atual Dirigente de laboratório, instituto, museu, centro ou observatório Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2008/09/01 - 2010/08/31 Head of the Natural Products Chemistry Department PharmaMar SA, Espanha
2002/04/01 - 2008/08/31 Team Leader. Natural Products Chemistry Department PharmaMar SA, Espanha
2000/08/01 - 2002/03/31 Senior Researcher. Natural Products Chemistry Department PharmaMar SA, Espanha
2000/04/17 - 2000/07/31 Researcher. Compound Bank Department GlaxoSmithKline España, Espanha
2000/01/01 - 2000/04/16 Postdoctoral Research Associate. Department of Applied Chemistry Universidad del País Vasco, Espanha
1999/10/01 - 1999/12/31 Postdoctoral Research Associate. Department of Microbiology Hospital Universitario Virgen de las Nieves, Espanha
1998/07/01 - 1999/06/30 Researcher. Natural Products Chemistry Department GlaxoSmithKline España, Espanha
1997/01/09 - 1998/06/30 Postdoctoral Research Associate. Department of Chemistry University of Cambridge, Reino Unido
1995/01/01 - 1995/04/21 Ph D Student. Department of Organic Chemistry Universidad de Granada, Espanha
Projetos

Bolsa

Designação Financiadores
2020/01 - Atual Caracterización de microorganismos asociados a líquenes de afloramientos yesíferos como fuente de metabolitos antimicrobianos frente a fitopatógenos y estudio de sus implicaciones biológicas
PY18-RE-0027
Investigador responsável
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
Junta de Andalucía Consejería de Economía, Conocimiento, Empresas y Universidad
Em curso
2017/01/01 - Atual Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients
info:eu-repo/grantAgreement/EC/H2020/720793/EU
Orientador
European Commission
2017/01 - Atual Integration of Informatics and Metabolic Engineering for the Discovery of Novel Antibiotics IIMENA
Orientador
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
Novo Nordisk Fonden
Em curso
2016/11/01 - Atual Improving the flow in the pipeline of the next generation of marine biodiscovery scientists
info:eu-repo/grantAgreement/EC/H2020/721421/EU
Investigador responsável
European Commission
2015/12/01 - Atual Ocean Medicines
info:eu-repo/grantAgreement/EC/H2020/690944/EU
Investigador responsável
European Commission
2024/01/01 - 2026/12/31 COMBO-Innovative cultivation methods for marine biodiscovery
Investigador responsável
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
European Commission
Em curso
2024/01/01 - 2026/12/31 European Research Infrastructure for Marine Bioprospecting (EUREMAP)
Investigador
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
Directorate-General for Research and Innovation
Em curso
2023/01/01 - 2026/12/31 MAtching Genes with MOLecules for FUNctional Analysis (MAGic-MOLFUN)
Co-Investigador Responsável (Co-IR)
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
European Commission Marie Sklodowska-Curie Actions
Em curso
2023/01 - 2026/12 HOTBIO- A holistic approach to training a new generation of scientists in marine biodiscovery
Co-Investigador Responsável (Co-IR)
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
European Commission Marie Sklodowska-Curie Actions
Em curso
2023/06/01 - 2026/05/31 circulaR bioecOnomy Business mOdels owned by agroCOOPeratives (ROBOCOOP-EU)
Investigador responsável
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
Directorate-General for Research and Innovation
Em curso
2021/05/01 - 2026/04/30 Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
101000392
Investigador
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
European Commission
Em curso
2019/10/29 - 2023/10/28 European transdisciplinary networking platform for marine biotechnology
Investigador
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
European Cooperation in Science and Technology
Em curso
2012/10 - 2017/03 Increasing Value and Flow in the Marine Biodiscovery Pipeline
info:eu-repo/grantAgreement/EC/FP7/312184/EU
Investigador responsável
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
European Commission
2012/10 - 2017/03 PharmaSea Directorate-General for Research and Innovation
2013/05 - 2016/09 Uso sostenible de plantas de zonas áridas de Andalucía y de sus parásitos fúngicos para la obtención de nuevas moléculas útiles en terapias antifúngicas y neuroprotectoras
RNM-7987
Investigador responsável
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha
Junta de Andalucía Consejería de Economía Innovación Ciencia y Empleo
Concluído
Produções

Publicações

Artigo em revista
  1. Laura Prado-Alonso; Suhui Ye; Ignacio Pérez-Victoria; Ignacio Montero; Pedro Riesco; Francisco Javier Ortiz-López; Jesús Martín; et al. "Genome Mining for Diazo-Synthesis-Related Genes in Streptomyces sp. CS057 Unveiled the Cryptic Biosynthetic Gene Cluster crx for the Novel 3,4-AHBA-Derived Compound Crexazone 2". Biomolecules (2024): https://doi.org/10.3390/biom14091084.
    10.3390/biom14091084
  2. Ignacio Fernández-Pastor; Victor González-Menéndez; Ignacio González; Rachel Serrano; Thomas A. Mackenzie; Guillermo Benítez; Manuel Casares-Porcel; Olga Genilloud; Fernando Reyes. "Escuzarmycins A–D, Potent Biofungicides to Control Septoria tritici Blotch". Journal of Agricultural and Food Chemistry (2024): https://doi.org/10.1021/acs.jafc.4c01303.
    10.1021/acs.jafc.4c01303
  3. F. Álvarez-León; J.A. Rosado-Aguilar; M. Gamboa-Angulo; G.J. Flota-Burgos; J. Martin; F. Reyes. "Anthelmintic activity and chemical profile of native plant extracts from the Yucatan Peninsula against Toxocara canis". Acta Tropica (2024): https://doi.org/10.1016/j.actatropica.2024.107214.
    10.1016/j.actatropica.2024.107214
  4. Mariana Girão; José Murillo-Alba; Jesús Martín; Ignacio Pérez-Victoria; Ricardo B. Leite; Ralph Urbatzka; Pedro N. Leão; Maria F. Carvalho; Fernando Reyes. "Cellulamides: A New Family of Marine-Sourced Linear Peptides from the Underexplored Cellulosimicrobium Genus". Marine Drugs (2024): https://doi.org/10.3390/md22060268.
    10.3390/md22060268
  5. Monserrat C. Esquivel-Chi; Esaú Ruiz-Sánchez; Horacio S. Ballina-Gómez; Jesús Martín; Fernando Reyes; Germán Carnevali; Jose L. Tapia-Muñoz; Marcela Gamboa-Angulo. "Repellent screening of ethanol extracts from plants of the Yucatan Peninsula against Bemisia tabaci (Gennadius, 1889) and chemical profile of Malpighia glabra L. leaves". Journal of Plant Diseases and Protection (2024): https://doi.org/10.1007/s41348-024-00901-5.
    10.1007/s41348-024-00901-5
  6. Laurence K. Jennings; Navdeep Kaur; Maria C. Ramos; Fernando Reyes; Maggie M. Reddy; Olivier P. Thomas. "Highly Concentrated Linear Guanidine Amides from the Marine Sipunculid Phascolosoma granulatum". Journal of Natural Products (2024): https://doi.org/10.1021/acs.jnatprod.3c01186.
    10.1021/acs.jnatprod.3c01186
  7. Ignacio Fernández-Pastor; Francisco Javier Ortiz-López; Daniel Oves-Costales; Jesús Martín; Pilar Sánchez; Ángeles Melguizo; Fernando Reyes; Tilmann Weber; Olga Genilloud. "Dilarmycins A–C, Calcium-Dependent Lipopeptide Antibiotics with a Non-canonical Ca2+-Binding Motif". Organic Letters (2024): https://doi.org/10.1021/acs.orglett.3c04195.
    10.1021/acs.orglett.3c04195
  8. Coral García-Gutiérrez; Ignacio Pérez-Victoria; Ignacio Montero; Jorge Fernández-De la Hoz; Mónica G. Malmierca; Jesús Martín; José A. Salas; et al. "Unearthing a Cryptic Biosynthetic Gene Cluster for the Piperazic Acid-Bearing Depsipeptide Diperamycin in the Ant-Dweller Streptomyces sp. CS113". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25042347.
    10.3390/ijms25042347
  9. Vitorino, Inês R.; Pinto, Eugénia; Martín, Jesús; Mackenzie, Thomas A.; Ramos, Maria C.; Sánchez, Pilar; de la Cruz, Mercedes; et al. "Uncovering the biotechnological capacity of marine and brackish water Planctomycetota". Antonie van Leeuwenhoek 117 1 (2024): https://doi.org/10.1007/s10482-023-01923-z.
    10.1007/s10482-023-01923-z
  10. José Diogo Neves dos Santos; Eugénia Pinto; Jesús Martín; Francisca Vicente; Fernando Reyes; Olga Maria Lage. "Unveiling the bioactive potential of Actinomycetota from the Tagus River estuary". International Microbiology (2024): https://doi.org/10.1007/s10123-024-00483-0.
    10.1007/s10123-024-00483-0
  11. Thomas A. Mackenzie; Fernando Reyes; Marta Martínez; Víctor González-Menéndez; Isabel Sánchez; Olga Genilloud; José R. Tormo; María C. Ramos. "Naphthoquinone Derivatives from Angustimassarina populi CF-097565 Display Anti-Tumour Activity in 3D Cultures of Breast Cancer Cells". Molecules (2024): https://doi.org/10.3390/molecules29020425.
    10.3390/molecules29020425
  12. Lidia Matias-Valiente; Cristina Sanchez-Fernandez; Lara Rodriguez-Outeiriño; Maria C. Ramos; Caridad Díaz; Gloria Crespo; Victor González-Menéndez; et al. "Evaluation of pro-regenerative and anti-inflammatory effects of isolecanoric acid in the muscle: Potential treatment of Duchenne Muscular Dystrophy". Biomedicine & Pharmacotherapy (2024): https://doi.org/10.1016/j.biopha.2023.116056.
    10.1016/j.biopha.2023.116056
  13. Sandra Resa; Marta González; Fernando Reyes; Ignacio Pérez-Victoria. "Revision of the full stereochemistry of telomycin". Organic Chemistry Frontiers (2024): https://doi.org/10.1039/D3QO01411H.
    10.1039/D3QO01411H
  14. Francisca Vicente; Fernando Reyes; Olga Genilloud. "Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides". Natural Product Reports (2024): https://doi.org/10.1039/D4NP00044G.
    10.1039/D4NP00044G
  15. Shauna O’Brien; Rodney Lacret; Maggie M. Reddy; Laurence K. Jennings; Pilar Sánchez; Fernando Reyes; Augustine Mungkaje; Kevin Calabro; Olivier P. Thomas. "Additional Sarasinosides from the Marine Sponge Melophlus sarasinorum Collected from the Bismarck Sea". Journal of Natural Products (2023): https://doi.org/10.1021/acs.jnatprod.3c01045.
    10.1021/acs.jnatprod.3c01045
  16. Mercedes Pérez-Bonilla; Marina Sánchez-Hidalgo; Ignacio González Martínez; Daniel Oves-Costales; Jesús Martín; José Murillo-Alba; Jose R Tormo; et al. "Madurastatins with Imidazolidinone Rings: Natural Products or Side-Reaction Products from Extraction Solvents?". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/25/1/301.
    10.3390/ijms25010301
  17. Ramón I. Santamaría; Ana Martínez-Carrasco; José R. Tormo; Jesús Martín; Olga Genilloud; Fernando Reyes; Margarita Díaz. "Interactions of Different Streptomyces Species and Myxococcus xanthus Affect Myxococcus Development and Induce the Production of DK-Xanthenes". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms242115659.
    10.3390/ijms242115659
  18. Ignacio Fernández-Pastor; Victor González-Menéndez; Kevin Martínez Andrade; Rachel Serrano; Thomas A. Mackenzie; Guillermo Benítez; Manuel Casares-Porcel; Olga Genilloud; Fernando Reyes. "Xerophytic Lichens from Gypsiferous Outcrops of Arid Areas of Andalusia as a Source of Anti-Phytopathogenic Depsides". Journal of Fungi (2023): https://doi.org/10.3390/jof9090887.
    10.3390/jof9090887
  19. Wei Huang; Janneth Rodrigues; Etienne Bilgo; José R. Tormo; Joseph D. Challenger; Cristina De Cozar-Gallardo; Ignacio Pérez-Victoria; et al. "Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes". Science (2023): https://doi.org/10.1126/science.adf8141.
    10.1126/science.adf8141
  20. Miguel A. Matilla; Terry J. Evans; Jesús Martín; Zulema Udaondo; Cristina Lomas-Martínez; Míriam Rico-Jiménez; Fernando Reyes; George P. C. Salmond. "Herbicolin A production and its modulation by quorum sensing in a Pantoea agglomerans rhizobacterium bioactive against a broad spectrum of plant-pathogenic fungi". Microbial Biotechnology (2023): https://doi.org/10.1111/1751-7915.14193.
    10.1111/1751-7915.14193
  21. Maria Kokkini; Daniel Oves-Costales; Pilar Sánchez; Ángeles Melguizo; Thomas A. Mackenzie; Mercedes Pérez-Bonilla; Jesús Martín; et al. "New Phocoenamicin and Maklamicin Analogues from Cultures of Three Marine-Derived Micromonospora Strains". Marine Drugs (2023): https://www.mdpi.com/1660-3397/21/8/443.
    10.3390/md21080443
  22. Santos, José Diogo Neves dos; Vitorino, Inês Rosado; Kallscheuer, Nicolai; Srivastava, Akash; Krautwurst, Sebastian; Marz, Manja; Jogler, Christian; et al. "Streptomyces marispadix sp. nov., isolated from marine beach sediment". International Journal of Systematic and Evolutionary Microbiology 73 7 (2023): https://doi.org/10.1099/ijsem.0.005956.
    10.1099/ijsem.0.005956
  23. José Diogo Neves dos Santos; Dominika Klimek; Magdalena Calusinska; Alexandre Lobo-da-Cunha; José Catita; Hugo Gonçalves; Ignacio González; Fernando Reyes; Olga Maria Lage. "Streptomyces meridianus sp. nov. isolated from brackish water of the Tagus estuary in Alcochete, Portugal". International Journal of Systematic and Evolutionary Microbiology (2023): https://doi.org/10.1099/ijsem.0.005987.
    10.1099/ijsem.0.005987
  24. Daniel Oves-Costales; Tetiana Gren; Eva Baggesgaard Sterndorff; Jesús Martín; Francisco Javier Ortiz-López; Tue S. Jørgensen; Xinglin Jiang; et al. "Identification and heterologous expression of the globomycin biosynthetic gene cluster". Synthetic and Systems Biotechnology (2023): https://doi.org/10.1016/j.synbio.2023.02.001.
    10.1016/j.synbio.2023.02.001
  25. Francisco Javier Ortiz-López; Daniel Oves-Costales; Daniel Carretero-Molina; Jesús Martín; Caridad Díaz; Mercedes de la Cruz; Fernando Román-Hurtado; et al. "Crossiellidines A–F, Unprecedented Pyrazine-Alkylguanidine Metabolites with Broad-Spectrum Antibacterial Activity from Crossiella sp.". Organic Letters (2023): https://doi.org/10.1021/acs.orglett.3c01088.
    10.1021/acs.orglett.3c01088
  26. Susana P. Gaudêncio; Engin Bayram; Lada Lukic Bilela; Mercedes Cueto; Ana R. Díaz-Marrero; Berat Z. Haznedaroglu; Carlos Jimenez; et al. "Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation". Marine Drugs (2023): https://doi.org/10.3390/md21050308.
    10.3390/md21050308
  27. Suhui Ye; Brian Molloy; Ignacio Pérez-Victoria; Ignacio Montero; Alfredo F. Braña; Carlos Olano; Sonia Arca; et al. "Uncovering the Cryptic Gene Cluster ahb for 3-amino-4-hydroxybenzoate Derived Ahbamycins, by Searching SARP Regulator Encoding Genes in the Streptomyces argillaceus Genome". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24098197.
    10.3390/ijms24098197
  28. Annang F; Guiomar Pérez-Moreno; Cristina Bosch-Navarrete; Victor Gonzalez-Menendez; Jesús Martín; Thomas A. Mackenzie; Carmen Ramos; et al. "Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/2/492.
    10.3390/pharmaceutics15020492
  29. Gattoni, G.; de la Haba, R.R.; Martín, J.; Reyes, F.; Sánchez-Porro, C.; Feola, A.; Zuchegna, C.; et al. "Genomic study and lipidomic bioassay of Leeuwenhoekiella parthenopeia: A novel rare biosphere marine bacterium that inhibits tumor cell viability". Frontiers in Microbiology 13 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85146530682&partnerID=MN8TOARS.
    10.3389/fmicb.2022.1090197
  30. Maria Kokkini; Cristina González Heredia; Daniel Oves-Costales; Mercedes de la Cruz; Pilar Sánchez; Jesús Martín; Francisca Vicente; Olga Genilloud; Fernando Reyes. "Exploring Micromonospora as Phocoenamicins Producers". Marine Drugs (2022): https://doi.org/10.3390/md20120769.
    10.3390/md20120769
  31. Suhui Ye; Giovanni Ballin; Ignacio Pérez-Victoria; Alfredo F. Braña; Jesús Martín; Fernando Reyes; José A. Salas; Carmen Méndez. "Combinatorial biosynthesis yields novel hybrid argimycin P alkaloids with diverse scaffolds in Streptomyces argillaceus". Microbial Biotechnology (2022): https://doi.org/10.1111/1751-7915.14167.
    10.1111/1751-7915.14167
  32. Ignacio Pérez-Victoria; Gloria Crespo; Fernando Reyes. "Expanding the utility of Marfey’s analysis by using HPLC-SPE-NMR to determine the Cß configuration of threonine and isoleucine residues in natural peptides". Analytical and Bioanalytical Chemistry (2022): https://doi.org/10.1007/s00216-022-04339-2.
    10.1007/s00216-022-04339-2
  33. Jorge R. Virués-Segovia; Fernando Reyes; Sandra Ruíz; Jesús Martín; Ignacio Fernández-Pastor; Carlos Justicia; Mercedes de la Cruz; et al. "Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens". Molecules (2022): https://doi.org/10.3390/molecules27196355.
    10.3390/molecules27196355
  34. Adriana Becerril; Ignacio Pérez-Victoria; Jesús M. Martín; Fernando Reyes; Jose A. Salas; Carmen Méndez. "Biosynthesis of Largimycins in Streptomyces argillaceus Involves Transient ß-Alkylation and Cryptic Halogenation Steps Unprecedented in the Leinamycin Family". ACS Chemical Biology (2022): https://doi.org/10.1021/acschembio.2c00416.
    10.1021/acschembio.2c00416
  35. José Diogo Neves dos Santos; Susana Afonso João; Jesús Martín; Francisca Vicente; Fernando Reyes; Olga Maria Lage. "iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments". Microorganisms 10 7 (2022): 1471-1471. https://doi.org/10.3390/microorganisms10071471.
    10.3390/microorganisms10071471
  36. Mohammed Aldholmi; Rizwan Ahmad; Daniel Carretero-Molina; Ignacio Pérez-Victoria; Jesús Martín; Fernando Reyes; Olga Genilloud; et al. "Euglenatides, Potent Antiproliferative Cyclic Peptides Isolated from the Freshwater Photosynthetic Microalga Euglena gracilis". Angewandte Chemie International Edition (2022): https://doi.org/10.1002/anie.202203175.
    10.1002/anie.202203175
  37. Gennaro Riccio; Kevin A. Martinez; Jesús Martín; Fernando Reyes; Isabella D’Ambra; Chiara Lauritano. "Jellyfish as an Alternative Source of Bioactive Antiproliferative Compounds". Marine Drugs 20 6 (2022): 350-350. https://doi.org/10.3390/md20060350.
    10.3390/md20060350
  38. Ramón I. Santamaría; Ana Martínez-Carrasco; Jesús Martín; José R. Tormo; Ignacio Pérez-Victoria; Ignacio González; Olga Genilloud; Fernando Reyes; Margarita Díaz. "Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production in Streptomyces spp.". Antibiotics 11 5 (2022): 672-672. https://doi.org/10.3390/antibiotics11050672.
    10.3390/antibiotics11050672
  39. Matilde Ortiz González; Ignacio Pérez-Victoria; Inmaculada Ramírez-Macías; Nuria de Pedro; Ángel Linde Rodríguez; Victor Gonzalez-Menendez; Victoria Sanchez-Martin; et al. "Curvicollide D Isolated from the Fungus Amesia sp. Kills African Trypanosomes by Inhibiting Transcription". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/11/6107.
    10.3390/ijms23116107
  40. Felicia Amalia Moo-Koh; Jairo Cristóbal-Alejo; María Fé Andrés; Jesús Martín; Fernando Reyes; Jose María Tun-Suárez; Marcela Gamboa-Angulo. "In Vitro Assessment of Organic and Residual Fractions of Nematicidal Culture Filtrates from Thirteen Tropical Trichoderma Strains and Metabolic Profiles of Most-Active". Journal of Fungi (2022): https://doi.org/10.3390/jof8010082.
    10.3390/jof8010082
  41. Maria Miguel-Gordo; Maggie M. Reddy; Pilar Sánchez; Jordan J. Buckley; Thomas A. Mackenzie; Laurence K. Jennings; Fernando Reyes; Kevin Calabro; Olivier P. Thomas. "Antifungal mono- and dimeric nitrogenous bisabolene derivatives from a sponge in the order Bubarida from Futuna Islands". Organic & Biomolecular Chemistry (2022): https://doi.org/10.1039/D1OB02297K.
    10.1039/D1OB02297K
  42. Prado-Alonso, L.; Pérez-Victoria, I.; Malmierca, M.G.; Montero, I.; Rioja-Blanco, E.; Martín, J.; Reyes, F.; et al. "Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase- Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147". Applied and Environmental Microbiology 88 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85120777564&partnerID=MN8TOARS.
    10.1128/AEM.01839-21
  43. Gimranov, E.; Santos, J.D.N.; Vitorino, I.; Martín, J.; Reyes, F.; Moura, L.; Tavares, F.; et al. "Marine bacterial activity against phytopathogenic Pseudomonas show high efficiency of Planctomycetes extracts". European Journal of Plant Pathology (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85123173558&partnerID=MN8TOARS.
    10.1007/s10658-021-02441-2
  44. Georgousaki, K.; González-Menéndez, V.; Tormo, J.R.; Tsafantakis, N.; Mackenzie, T.A.; Martín, J.; Gumeni, S.; et al. "Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants". Scientific Reports 12 1 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85123933680&partnerID=MN8TOARS.
    10.1038/s41598-022-05448-9
  45. Carretero-Molina, D.; Ortiz-López, F.J.; Gren, T.; Oves-Costales, D.; Martín, J.; Román-Hurtado, F.; Sparholt Jørgensen, T.; et al. "Discovery of gargantulides B and C, new 52-membered macrolactones from: Amycolatopsis sp. Complete absolute stereochemistry of the gargantulide family". Organic Chemistry Frontiers 9 2 (2022): 462-470. http://www.scopus.com/inward/record.url?eid=2-s2.0-85123483131&partnerID=MN8TOARS.
    10.1039/d1qo01480c
  46. Reyes, F.; Bills, G.F.; Durán-Patrón, R.. "Editorial: Strategies for the Discovery of Fungal Natural Products". Frontiers in Microbiology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85130598057&partnerID=MN8TOARS.
    10.3389/fmicb.2022.897756
  47. Sarmiento-Vizcaíno, A.; Martín, J.; Ortiz-López, F.J.; Reyes, F.; García, L.A.; Blanco, G.. "Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin". Frontiers in Chemistry 10 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85142141426&partnerID=MN8TOARS.
    10.3389/fchem.2022.948795
  48. Slemc, L.; Jakše, J.; Filisetti, A.; Baranasic, D.; Rodríguez-García, A.; Carratore, F.D.; Marino, S.M.; et al. "Reference-Grade Genome and Large Linear Plasmid of Streptomyces rimosus: Pushing the Limits of Nanopore Sequencing". Microbiology Spectrum 10 2 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85129249756&partnerID=MN8TOARS.
    10.1128/spectrum.02434-21
  49. Martínez, K.A.; Saide, A.; Crespo, G.; Martín, J.; Romano, G.; Reyes, F.; Lauritano, C.; Ianora, A.. "Promising Antiproliferative Compound From the Green Microalga Dunaliella tertiolecta Against Human Cancer Cells". Frontiers in Marine Science 9 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85125724608&partnerID=MN8TOARS.
    10.3389/fmars.2022.778108
  50. Juan Manuel Álvarez-Caballero; Luis Enrique Cuca-Suárez; Ericsson Coy-Barrera; Alegría Carrasco-Pancorbo; Lucía Olmo-García; Jesús Martin; Mercedes de la Cruz; Ignacio Perez-Victoria; Fernando Reyes. "Caerulines A and B, Flavonol Diacylglycosides from Persea caerulea". ACS Omega (2021): https://doi.org/10.1021/acsomega.1c04255.
    10.1021/acsomega.1c04255
  51. Bertalan Juhasz; Dawrin Pech-Puch; Jioji N. Tabudravu; Bastien Cautain; Fernando Reyes; Carlos Jiménez; Kwaku Kyeremeh; Marcel Jaspars. "Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV–Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1T". Marine Drugs 19 6 (2021): 325-325. https://doi.org/10.3390/md19060325.
    10.3390/md19060325
  52. Daniel Carretero-Molina; Francisco Javier Ortiz-López; Jesús Martín; Ignacio González; Marina Sánchez-Hidalgo; Fernando Román-Hurtado; Caridad Díaz; et al. "Pentaminomycins F and G, Nonribosomal Peptides Containing 2-Pyridylalanine". Journal of Natural Products (2021): https://doi.org/10.1021/acs.jnatprod.0c01199.
    10.1021/acs.jnatprod.0c01199
  53. Ignacio Fernández-Pastor; Victor González-Menéndez; Frederick Annang; Clara Toro; Thomas Mackenzie; Cristina Bosch-Navarrete; Olga Genilloud; Fernando Reyes. "Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae". Pharmaceuticals 14 3 (2021): 268-268. https://doi.org/10.3390/ph14030268.
    10.3390/ph14030268
  54. Karolina Subko; Sara Kildgaard; Francisca Vicente; Fernando Reyes; Olga Genilloud; Thomas O. Larsen. "Bioactive Ascochlorin Analogues from the Marine-Derived Fungus Stilbella fimetaria". Marine Drugs (2021): https://doi.org/10.3390/md19020046.
    10.3390/md19020046
  55. Fernando Román-Hurtado; Marina Sánchez-Hidalgo; Jesús Martín; Francisco Javier Ortiz-López; Daniel Carretero-Molina; Fernando Reyes; Olga Genilloud. "One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from Streptomyces cacaoi CA-170360". Microorganisms 9 1 (2021): 135-135. https://doi.org/10.3390/microorganisms9010135.
    10.3390/microorganisms9010135
  56. Sarmiento-Vizcaíno, A.; Martín, J.; Reyes, F.; García, L.A.; Blanco, G.. "Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain". Frontiers in Microbiology 12 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85120429930&partnerID=MN8TOARS.
    10.3389/fmicb.2021.773095
  57. Breitling, R.; Avbelj, M.; Bilyk, O.; Carratore, F.D.; Filisetti, A.; Hanko, E.K.R.; Iorio, M.; et al. "Synthetic biology approaches to actinomycete strain improvement". FEMS Microbiology Letters 368 10 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85108304407&partnerID=MN8TOARS.
    10.1093/femsle/fnab060
  58. Annang, F.; Pérez-Moreno, G.; Díaz, C.; González-Menéndez, V.; de Pedro Montejo, N.; del Palacio, J.P.; Sánchez, P.; et al. "Preclinical evaluation of strasseriolides A–D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251". Malaria Journal 20 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85120740101&partnerID=MN8TOARS.
    10.1186/s12936-021-03993-8
  59. Rotter, A.; Barbier, M.; Bertoni, F.; Bones, A.M.; Cancela, M.L.; Carlsson, J.; Carvalho, M.F.; et al. "The Essentials of Marine Biotechnology". Frontiers in Marine Science 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85103423925&partnerID=MN8TOARS.
    10.3389/fmars.2021.629629
  60. Kontou, E.E.; Gren, T.; Ortiz-López, F.J.; Thomsen, E.; Oves-Costales, D.; Díaz, C.; De La Cruz, M.; et al. "Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260". ACS Chemical Biology 16 8 (2021): 1456-1468. http://www.scopus.com/inward/record.url?eid=2-s2.0-85111565418&partnerID=MN8TOARS.
    10.1021/acschembio.1c00318
  61. Ramón I. Santamaría; Ana Martínez-Carrasco; Ricardo Sánchez de la Nieta; Luis M. Torres-Vila; Raúl Bonal; Jesús Martín; Rubén Tormo; et al. "Characterization of Actinomycetes Strains Isolated from the Intestinal Tract and Feces of the Larvae of the Longhorn Beetle Cerambyx welensii". Microorganisms 8 12 (2020): 2013-2013. https://doi.org/10.3390/microorganisms8122013.
    10.3390/microorganisms8122013
  62. Kevin Calabro; Laurence K. Jennings; Perrine Lasserre; Roisin Doohan; Daniel Rodrigues; Fernando Reyes; Carmen Ramos; Olivier P. Thomas. "Nebulosins: Trisubstituted Thiolane Natural Products from the Northeastern Atlantic Annelid Eupolymnia nebulosa". The Journal of Organic Chemistry (2020): https://doi.org/10.1021/acs.joc.0c02060.
    10.1021/acs.joc.0c02060
  63. Patricia Cruz-Cerino; Jairo Cristóbal-Alejo; Violeta Ruiz-Carrera; Germán Carnevali; Marina Vera-Ku; Jesús Martín; Fernando Reyes; Marcela Gamboa-Angulo. "Extracts from Six Native Plants of the Yucatán Peninsula Hinder Mycelial Growth of Fusarium equiseti and F. oxysporum, Pathogens of Capsicum chinense". Pathogens (2020): https://doi.org/10.3390/pathogens9100827.
    10.3390/pathogens9100827
  64. Mercedes Pérez-Bonilla; Daniel Oves-Costales; Ignacio González; Mercedes de la Cruz; Jesús Martín; Francisca Vicente; Olga Genilloud; Fernando Reyes. "Krisynomycins, Imipenem Potentiators against Methicillin-Resistant Staphylococcus aureus, Produced by Streptomyces canus". Journal of Natural Products (2020): https://doi.org/10.1021/acs.jnatprod.0c00294.
    10.1021/acs.jnatprod.0c00294
  65. Paulina Bekiesch; Martin Zehl; Elizabeth Domingo-Contreras; Jesús Martín; Ignacio Pérez-Victoria; Fernando Reyes; Arthur Kaplan; et al. "Viennamycins: Lipopeptides Produced by a Streptomyces sp.". Journal of Natural Products (2020): https://doi.org/10.1021/acs.jnatprod.0c00152.
    10.1021/acs.jnatprod.0c00152
  66. José Diogo Santos; Inês Vitorino; Fernando Reyes; Francisca Vicente; Olga Maria Lage. "From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria". Antibiotics 9 8 (2020): 455-455. https://doi.org/10.3390/antibiotics9080455.
    10.3390/antibiotics9080455
  67. Adriana Becerril; Ignacio Pérez-Victoria; Suhui Ye; Alfredo F. Braña; Jesús Martín; Fernando Reyes; José A. Salas; Carmen Méndez. "Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family". ACS Chemical Biology (2020): https://doi.org/10.1021/acschembio.0c00160.
    10.1021/acschembio.0c00160
  68. Gloria Crespo; Ignacio Pérez-Victoria; Francisco Javier Ortiz-López; Víctor González-Menéndez; Mercedes de la Cruz; Bastien Cautain; Pilar Sánchez; et al. "Structural Elucidation of Antibiotic TKR2999, an Antifungal Lipodepsipeptide Isolated from the Fungus Foliophoma fallens". Antibiotics 9 6 (2020): 278-278. https://doi.org/10.3390/antibiotics9060278.
    10.3390/antibiotics9060278
  69. Katerina Georgousaki; Nikolaos Tsafantakis; Sentiljana Gumeni; Ignacio Gonzalez; Thomas Andrew Mackenzie; Fernando Reyes; Carole Lambert; et al. "Screening for tyrosinase inhibitors from actinomycetes; identification of trichostatin derivatives from Streptomyces sp. CA-129531 and scale up production in bioreactor". Bioorganic & Medicinal Chemistry Letters 30 6 (2020): 126952-126952. https://doi.org/10.1016/j.bmcl.2020.126952.
    10.1016/j.bmcl.2020.126952
  70. Qing Fang; Fleurdeliz Maglangit; Linrui Wu; Rainer Ebel; Kwaku Kyeremeh; Jeanette H. Andersen; Frederick Annang; et al. "Signalling and Bioactive Metabolites from Streptomyces sp. RK44". Molecules 25 3 (2020): 460-460. https://doi.org/10.3390/molecules25030460.
    10.3390/molecules25030460
  71. Ortiz-López, F.J.; Carretero-Molina, D.; Sánchez-Hidalgo, M.; Martín, J.; González, I.; Román-Hurtado, F.; de la Cruz, M.; et al. "Cacaoidin, First Member of the New Lanthidin RiPP Family". Angewandte Chemie - International Edition 59 31 (2020): 12654-12658. http://www.scopus.com/inward/record.url?eid=2-s2.0-85086388199&partnerID=MN8TOARS.
    10.1002/anie.202005187
  72. Rotter, A.; Bacu, A.; Barbier, M.; Bertoni, F.; Bones, A.M.; Cancela, M.L.; Carlsson, J.; et al. "A New Network for the Advancement of Marine Biotechnology in Europe and Beyond". Frontiers in Marine Science 7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85085358556&partnerID=MN8TOARS.
    10.3389/fmars.2020.00278
  73. Annang, F.; Perez-Moreno, G.; Gonzalez-Menendez, V.; Lacret, R.; Perez-Victoria, I.; Martín, J.; Cantizani, J.; et al. "Strasseriolides A-D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251". Organic Letters 22 17 (2020): 6709-6713. http://www.scopus.com/inward/record.url?eid=2-s2.0-85090491673&partnerID=MN8TOARS.
    10.1021/acs.orglett.0c01665
  74. Oluwabusola, E.T.; Tabudravu, J.N.; Al Maqbali, K.S.; Annang, F.; Pérez-Moreno, G.; Reyes, F.; Jaspars, M.. "Antiparasitic Activity of Bromotyrosine Alkaloids and New Analogues Isolated from the Fijian Marine Sponge Aplysinella rhax". Chemistry and Biodiversity 17 10 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85091603607&partnerID=MN8TOARS.
    10.1002/cbdv.202000335
  75. Pech-Puch, D.; Berastegui-Cabrera, J.; Pérez-Povedano, M.; Villegas-Hernández, H.; Guillén-Hernández, S.; Cautain, B.; Reyes, F.; et al. "Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico". Frontiers in Marine Science 7 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090233054&partnerID=MN8TOARS.
    10.3389/fmars.2020.00607
  76. Lauritano, C.; Martínez, K.A.; Battaglia, P.; Granata, A.; de la Cruz, M.; Cautain, B.; Martín, J.; et al. "First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species". Scientific Reports 10 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85082062398&partnerID=MN8TOARS.
    10.1038/s41598-020-61515-z
  77. Malmierca, M.G.; Pérez-Victoria, I.; Martín, J.; Reyes, F.; Méndez, C.; Salas, J.A.; Olano, C.. "New sipanmycin analogues generated by combinatorial biosynthesis and mutasynthesis approaches relying on the substrate flexibility of key enzymes in the biosynthetic pathway". Applied and Environmental Microbiology 86 3 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078554327&partnerID=MN8TOARS.
    10.1128/AEM.02453-19
  78. Koagne, R.R.; Annang, F.; Cautain, B.; Martín, J.; Pérez-Moreno, G.; Bitchagno, G.T.M.; González-Pacanowska, D.; et al. "Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae)". BMC Complementary Medicine and Therapies 20 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85103307778&partnerID=MN8TOARS.
    10.1186/s12906-019-2792-1
  79. Daniel Carretero-Molina; Francisco Javier Ortiz-López; Jesús Martín; Daniel Oves-Costales; Caridad Díaz; Mercedes de la Cruz; Bastien Cautain; et al. "New Napyradiomycin Analogues from Streptomyces sp. Strain CA-271078". Marine Drugs (2019): https://doi.org/10.3390/md18010022.
    10.3390/md18010022
  80. Diana Escalante-Réndiz; Susana de-la-Rosa-García; Raúl Tapia-Tussell; Jesús Martín; Fernando Reyes; Francisca Vicente; Marcela Gamboa-Angulo. "Molecular Identification of Selected Streptomyces Strains Isolated from Mexican Tropical Soils and their Anti-Candida Activity". International Journal of Environmental Research and Public Health 16 11 (2019): 1913-1913. https://doi.org/10.3390/ijerph16111913.
    10.3390/ijerph16111913
  81. Paul O. Guillen; Karla B. Jaramillo; Laurence Jennings; Grégory Genta-Jouve; Mercedes de la Cruz; Bastien Cautain; Fernando Reyes; Jenny Rodríguez; Olivier P. Thomas. "Halogenated Tyrosine Derivatives from the Tropical Eastern Pacific Zoantharians Antipathozoanthus hickmani and Parazoanthus darwini". Journal of Natural Products (2019): https://doi.org/10.1021/acs.jnatprod.9b00173.
    10.1021/acs.jnatprod.9b00173
  82. Halima Khentoul; Chawki Bensouici; Fernando Reyes; Domenico Albanese; Djamel Sarri; Mekkiou Ratiba; Benayache Fadila; Ramdane Seghiri; Ouahiba Boumaza. "Chemical constituents and HRESI-MS analysis of an Algerian endemic plant - Verbascum atlanticum batt. - extracts and their antioxidant activity". Natural Product Research (2019): https://doi.org/10.1080/14786419.2019.1602829.
    10.1080/14786419.2019.1602829
  83. Alvariño R; Alonso E; Lacret R; Oves-Costales D; Genilloud O; Reyes F; Alfonso A; Botana LM. "Caniferolide A, a macrolide from Streptomyces caniferus, attenuates neuroinflammation, oxidative stress, amyloid-beta and tau pathology in vitro.". Molecular pharmaceutics (2019): http://europepmc.org/abstract/med/30821469.
    10.1021/acs.molpharmaceut.8b01090
  84. Alfredo F. Braña; Aida Sarmiento-Vizcaíno; Ignacio Pérez-Victoria; Jesús Martín; Luis Otero; Juan José Palacios-Gutiérrez; Jonathan Fernández; et al. "Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.". Marine Drugs (2019): http://www.mdpi.com/1660-3397/17/2/114.
    10.3390/md17020114
  85. Ignacio Pérez-Victoria; Daniel Oves-Costales; Rodney Lacret; Jesús Martín; Marina Sánchez-Hidalgo; Caridad Díaz; Bastien Cautain; et al. "Structure elucidation and biosynthetic gene cluster analysis of caniferolides A–D, new bioactive 36-membered macrolides from the marine-derived Streptomyces caniferus CA-271066". Organic & Biomolecular Chemistry 17 11 (2019): 2954-2971. https://doi.org/10.1039/C8OB03115K.
    10.1039/C8OB03115K
  86. Tejman-Yarden, N.; Robinson, A.; Davidov, Y.; Shulman, A.; Varvak, A.; Reyes, F.; Rahav, G.; Nissan, I.. "Delftibactin-a, a non-ribosomal peptide with broad antimicrobial activity". Frontiers in Microbiology 10 OCT (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074569207&partnerID=MN8TOARS.
    10.3389/fmicb.2019.02377
  87. Martínez, K.A.; Lauritano, C.; Druka, D.; Romano, G.; Grohmann, T.; Jaspars, M.; Martín, J.; et al. "Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae". Marine Drugs 17 7 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068619868&partnerID=MN8TOARS.
    10.3390/md17070385
  88. Berenguel Hernández, A.M.; de la Cruz, M.; Alcázar-Fabra, M.; Prieto-Rodríguez, A.; Sánchez-Cuesta, A.; Martin, J.; Tormo, J.R.; et al. "Design of High-Throughput Screening of Natural Extracts to Identify Molecules Bypassing Primary Coenzyme Q Deficiency in Saccharomyces cerevisiae". SLAS Discovery (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075465960&partnerID=MN8TOARS.
    10.1177/2472555219877185
  89. Martínez-Burgo, Y.; Santos-Aberturas, J.; Rodríguez-García, A.; Barreales, E.G.; Tormo, J.R.; Truman, A.W.; Reyes, F.; Aparicio, J.F.; Liras, P.. "Activation of secondary metabolite gene clusters in streptomyces clavuligerusby the pimm regulator of streptomyces natalensis". Frontiers in Microbiology 10 MAR (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85066619993&partnerID=MN8TOARS.
    10.3389/fmicb.2019.00580
  90. Escalante-Réndiz, D.; De-La-rosa-garcía, S.; Tapia-Tussell, R.; Martín, J.; Reyes, F.; Vicente, F.; Gamboa-Ángulo, M.. "Evaluation of the anti-Candida activity of Streptomyces genus strains isolated from Mexican tropical soils,Evaluación de la actividad anti-candida de cepas del género Streptomyces, aisladas de suelos tropicales Mexicanos". Revista Latinoamericana de Quimica 47 1 (2019): 237-237. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104456641&partnerID=MN8TOARS.
  91. Chiara Lauritano; Jesús Martín; Mercedes de la Cruz; Fernando Reyes; Giovanna Romano; Adrianna Ianora. "Author Correction: First identification of marine diatoms with anti-tuberculosis activity". Scientific Reports (2018): https://doi.org/10.1038/s41598-018-24176-7.
    10.1038/s41598-018-24176-7
  92. Chiara Lauritano; Jesús Martín; Mercedes de la Cruz; Fernando Reyes; Giovanna Romano; Adrianna Ianora. "First identification of marine diatoms with anti-tuberculosis activity". Scientific Reports 8 1 (2018): https://doi.org/10.1038/s41598-018-20611-x.
    10.1038/s41598-018-20611-x
  93. Kevin Calabro; Bolivar E. Chalén; Grégory Genta-Jouve; Karla B. Jaramillo; Cristóbal Domínguez; Mercedes de la Cruz; Bastien Cautain; et al. "Callyspongidic Acids: Amphiphilic Diacids from the Tropical Eastern Pacific Sponge Callyspongia cf. californica". Journal of Natural Products (2018): https://doi.org/10.1021/acs.jnatprod.8b00683.
    10.1021/acs.jnatprod.8b00683
  94. Víctor Rodríguez; Jesús Martín; Aida Sarmiento-Vizcaíno; Mercedes de la Cruz; Luis García; Gloria Blanco; Fernando Reyes. "Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169". Marine Drugs (2018): https://doi.org/10.3390/md16110406.
    10.3390/md16110406
  95. Francisco Ortiz-López; Elsa Alcalde; Aida Sarmiento-Vizcaíno; Caridad Díaz; Bastien Cautain; Luis García; Gloria Blanco; Fernando Reyes. "New 3-Hydroxyquinaldic Acid Derivatives from Cultures of the Marine Derived Actinomycete Streptomyces cyaneofuscatus M-157". Marine Drugs (2018): https://doi.org/10.3390/md16100371.
    10.3390/md16100371
  96. Alvariño R; Alonso E; Lacret R; Oves-Costales D; Genilloud O; Reyes F; Alfonso A; Botana LM. "Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitro.". Neuropharmacology (2018): http://europepmc.org/abstract/med/30205103.
    10.1016/j.neuropharm.2018.09.008
  97. Malmierca MG; Pérez-Victoria I; Martín J; Reyes F; Méndez C; Olano C; Salas JA; et al. "Cooperative involvement of glycosyltransferases in the transfer of aminosugars in the biosynthesis of the macrolactam sipanmycin by Streptomyces sp. CS149.". Applied and environmental microbiology 84 18 (2018): http://europepmc.org/abstract/med/30006405.
    10.1128/aem.01462-18
  98. Celso Almeida; Ignacio Pérez-Victoria; Víctor González-Menéndez; Nuria de Pedro; Jesús Martín; Gloria Crespo; Thomas Mackenzie; et al. "Non-geminal Aliphatic Dihalogenation Pattern in Dichlorinated Diaporthins from Hamigera fusca NRRL 35721". Journal of Natural Products (2018): https://doi.org/10.1021/acs.jnatprod.8b00041.
    10.1021/acs.jnatprod.8b00041
  99. González-Menéndez V; Crespo G; de Pedro N; Diaz C; Martín J; Serrano R; Mackenzie TA; et al. "Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents.". Scientific reports (2018): http://europepmc.org/abstract/med/29950656.
    10.1038/s41598-018-28192-5
  100. Annang F; Pérez-Victoria I; Pérez-Moreno G; Domingo E; González I; Tormo JR; Martín J; et al. "MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353.". Journal of natural products (2018): http://europepmc.org/abstract/med/29924612.
    10.1021/acs.jnatprod.8b00323
  101. Copmans D; Rateb M; Tabudravu JN; Pérez-Bonilla M; Dirkx N; Vallorani R; Diaz C; et al. "Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A.". ACS chemical neuroscience (2018): http://europepmc.org/abstract/med/29672015.
    10.1021/acschemneuro.8b00060
  102. Annang F; Pérez-Victoria I; Appiah T; Pérez-Moreno G; Domingo E; Martín J; Mackenzie T; et al. "Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms.". Fitoterapia (2018): http://europepmc.org/abstract/med/29625145.
    10.1016/j.fitote.2018.03.016
  103. Pérez-Bonilla M; Oves-Costales D; de la Cruz M; Kokkini M; Martín J; Vicente F; Genilloud O; Reyes F. "Phocoenamicins B and C, New Antibacterial Spirotetronates Isolated from a Marine Micromonospora sp.". Marine drugs (2018): http://europepmc.org/abstract/med/29547589.
    10.3390/md16030095
  104. Rodney Lacret; Daniel Oves-Costales; Ignacio Pérez-Victoria; Mercedes de la Cruz; Caridad Díaz; Francisca Vicente; Olga Genilloud; Fernando Reyes. "MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053". Natural Product Research (2018): 1-8. https://doi.org/10.1080/14786419.2018.1434636.
    10.1080/14786419.2018.1434636
  105. Malmierca MG; González-Montes L; Pérez-Victoria I; Sialer C; Braña AF; García Salcedo R; Martín J; et al. "Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines.". Frontiers in microbiology (2018): http://europepmc.org/abstract/med/29441046.
    10.3389/fmicb.2018.00039
  106. Sarmiento-Vizcaíno A; Espadas J; Martín J; Braña AF; Reyes F; García LA; Blanco G. "Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.". Frontiers in microbiology (2018): http://europepmc.org/abstract/med/29740412.
    10.3389/fmicb.2018.00773
  107. Koagne, R.R.; Annang, F.; De La Cruz, M.; Bitchagno, G.T.M.; Perez-Victoria, I.; Konga, I.S.; Vicente, F.; Reyes, F.; Tane, P.. "Antibacterial activity of flavans from crinum distichum". Natural Product Communications 13 12 (2018): 1637-1638. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059572379&partnerID=MN8TOARS.
  108. Solanki, H.; Angulo-Preckler, C.; Calabro, K.; Kaur, N.; Lasserre, P.; Cautain, B.; de la Cruz, M.; et al. "Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905)". Tetrahedron Letters 59 36 (2018): 3353-3356. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050759452&partnerID=MN8TOARS.
    10.1016/j.tetlet.2018.07.055
  109. Benítez, Jose. "Paulomycin G, a New Natural Product with Cytotoxic Activity against Tumor Cell Lines Produced by Deep-Sea Sediment Derived Micromonospora matsumotoense M-412 from the Avilés Canyon in the Cantabrian Sea". Marine Drugs (2017): http://www.mdpi.com/1660-3397/15/9/271.
    10.3390/md15090271
  110. González A; Gálvez N; Martín J; Reyes F; Pérez-Victoria I; Dominguez-Vera JM. "Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption.". (2017): http://europepmc.org/abstract/med/28317737.
    10.1016/j.foodchem.2017.02.008
  111. Benítez, Jose. "Poecillastrosides, Steroidal Saponins from the Mediterranean Deep-Sea Sponge Poecillastra compressa (Bowerbank, 1866)". Marine Drugs (2017): http://www.mdpi.com/1660-3397/15/7/199.
    10.3390/md15070199
  112. Braña AF; Sarmiento-Vizcaíno A; Osset M; Pérez-Victoria I; Martín J; de Pedro N; de la Cruz M; et al. "Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa.". (2017): http://europepmc.org/abstract/med/28534807.
    10.3390/md15050144
  113. Pérez-Bonilla M; González-Menéndez V; Pérez-Victoria I; de Pedro N; Martín J; Molero-Mesa J; Casares-Porcel M; et al. "Hormonemate Derivatives from Dothiora sp., an Endophytic Fungus.". (2017): http://europepmc.org/abstract/med/28277681.
    10.1021/acs.jnatprod.6b00680
  114. Braña AF; Sarmiento-Vizcaíno A; Pérez-Victoria I; Otero L; Fernández J; Palacios JJ; Martín J; et al. "Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M-227.". Journal of Natural Products 80 2 (2017): 569-573. http://europepmc.org/abstract/med/28169531.
    10.1021/acs.jnatprod.6b01107
  115. Paytubi S; de La Cruz M; Tormo JR; Martín J; González I; González-Menendez V; Genilloud O; et al. "A High-Throughput Screening Platform of Microbial Natural Products for the Discovery of Molecules with Antibiofilm Properties against Salmonella.". (2017): http://europepmc.org/abstract/med/28303128.
    10.3389/fmicb.2017.00326
  116. de la Cruz M; González I; Parish CA; Onishi R; Tormo JR; Martín J; Peláez F; et al. "Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes.". (2017): http://europepmc.org/abstract/med/28321210.
    10.3389/fmicb.2017.00343
  117. Firsova, D.; Calabro, K.; Lasserre, P.; Reyes, F.; Thomas, O.P.; Benítez, Jose. "Isoguanosine derivatives from the Northeastern Atlantic sponge Clathria (Microciona) strepsitoxa". Tetrahedron Letters 58 49 (2017): 4652-4654. http://www.scopus.com/inward/record.url?eid=2-s2.0-85033229839&partnerID=MN8TOARS.
    10.1016/j.tetlet.2017.10.079
  118. Gonzalez-Menendez, V.; Martin, J.; Siles, J.A.; Gonzalez-Tejero, M.R.; Reyes, F.; Platas, G.; Tormo, J.R.; Genilloud, O.. "Biodiversity and chemotaxonomy of Preussia isolates from the Iberian Peninsula". Mycological Progress 16 7 (2017): 713-728. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018671894&partnerID=MN8TOARS.
    10.1007/s11557-017-1305-1
  119. Oluwabusola, E.T.; Adebisi, O.O.; Reyes, F.; Acquah, K.S.; de la Cruz, M.; Mweetwa, L.L.; Rajakulendran, J.E.; et al. "Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B". Beilstein Journal of Organic Chemistry 13 (2017): 2390-2398. http://www.scopus.com/inward/record.url?eid=2-s2.0-85117895545&partnerID=MN8TOARS.
    10.3762/BJOC.TESTX12TY90W99C
  120. El Aouad N; Annang F; Pérez-Victoria I; Martín J; Crespo G; Domingo E; Pérez-Moreno G; et al. "New antiplasmodial compounds discovered by High Throughput Screening (HTS) of a collection of microbial natural extracts.". (2016): http://europepmc.org/abstract/med/27975886.
  121. Pérez-Bonilla M; González-Menendez V; de Pedro N; Pérez-Victoria I; Martín J; Vicente F; Genilloud O; Tormo JR; Reyes F. "New hormonemate derivatives from the endophytic fungus Dothiora sp.". (2016): http://europepmc.org/abstract/med/27975926.
  122. Crespo G; González-Menéndez V; de la Cruz M; Martín J; Cautain B; Sánchez P; Pérez-Victoria I; et al. "Antifungal Long-Chain Alkenyl Sulphates Isolated from Culture Broths of the Fungus Chaetopsina sp.". Planta Medica 83 6 (2016): 545-550. http://europepmc.org/abstract/med/27706529.
    10.1055/s-0042-118190
  123. Benítez, Jose. "MDN-0170, a New Napyradiomycin from Streptomyces sp. Strain CA-271078". Marine Drugs (2016): http://www.mdpi.com/1660-3397/14/10/188.
    10.3390/md14100188
  124. Benítez, Jose. "New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07". Molecules (2016): http://www.mdpi.com/1420-3049/21/9/1131.
    10.3390/molecules21091131
  125. Angulo-Preckler C; Genta-Jouve G; Mahajan N; de la Cruz M; de Pedro N; Reyes F; Iken K; Avila C; Thomas OP. "Gersemiols A-C and Eunicellol A, Diterpenoids from the Arctic Soft Coral Gersemia fruticosa.". (2016): http://europepmc.org/abstract/med/26894524.
    10.1021/acs.jnatprod.6b00040
  126. Pérez-Victoria I; Martín J; Reyes F. "Correction: Combined LC/UV/MS and NMR Strategies for the Dereplication of Marine Natural Products.". (2016): http://europepmc.org/abstract/med/27124239.
  127. Pérez Del Palacio J; Díaz C; de la Cruz M; Annang F; Martín J; Pérez-Victoria I; González-Menéndez V; et al. "High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries.". Journal of Biomolecular Screening 21 6 (2016): 567-578. http://europepmc.org/abstract/med/26962874.
    10.1177/1087057116635517
  128. de Pedro N; Cantizani J; Ortiz-López FJ; González-Menéndez V; Cautain B; Rodríguez L; Bills GF; et al. "Protective effects of isolecanoric acid on neurodegenerative in vitro models.". (2016): http://europepmc.org/abstract/med/26455662.
    10.1016/j.neuropharm.2015.09.029
  129. González-Menéndez V; Pérez-Bonilla M; Pérez-Victoria I; Martín J; Muñoz F; Reyes F; Tormo JR; Genilloud O. "Multicomponent Analysis of the Differential Induction of Secondary Metabolite Profiles in Fungal Endophytes.". (2016): http://europepmc.org/abstract/med/26901184.
    10.3390/molecules21020234
  130. Pérez-Moreno G; Cantizani J; Sánchez-Carrasco P; Ruiz-Pérez LM; Martín J; El Aouad N; Pérez-Victoria I; et al. "Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products.". (2016): http://europepmc.org/abstract/med/26735308.
    10.1371/journal.pone.0145812
  131. Pérez, M.; Schleissner, C.; Fernández, R.; Rodríguez, P.; Reyes, F.; Zuñiga, P.; De La Calle, F.; et al. "PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A". Journal of Antibiotics 69 5 (2016): 388-394. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971294660&partnerID=MN8TOARS.
    10.1038/ja.2015.121
  132. Pérez-Victoria, I.; Martín, J.; Reyes, F.; Pérez-Victoria I; Martín J; Reyes F. "Combined LC/UV/MS and NMR Strategies for the Dereplication of Marine Natural Products". Planta Medica 82 9-10 (2016): 857-871. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961618649&partnerID=MN8TOARS.
    10.1055/s-0042-101763
  133. Jaspars, M.; De Pascale, D.; Andersen, J.H.; Reyes, F.; Crawford, A.D.; Ianora, A.. "The marine biodiscovery pipeline and ocean medicines of tomorrow". Journal of the Marine Biological Association of the United Kingdom 96 1 (2016): 151-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962476646&partnerID=MN8TOARS.
    10.1017/S0025315415002106
  134. Annang F; Pérez-Moreno G; García-Hernández R; Cordon-Obras C; Martín J; Tormo JR; Rodríguez L; et al. "High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human african trypanosomiasis, leishmaniasis, and chagas disease.". (2015): http://europepmc.org/abstract/med/25332350.
    10.1177/1087057114555846
  135. Molina-Santiago, C.; Udaondo, Z.; Daddaoua, A.; Roca, A.; Martín, J.; Pérez-Victoria, I.; Reyes, F.; Ramos, J.-L.. "Efflux pump-deficient mutants as a platform to search for microbes that produce antibiotics". Microbial Biotechnology 8 4 (2015): 716-725. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930868727&partnerID=MN8TOARS.
    10.1111/1751-7915.12295
  136. Ortíz-López, F.J.; Monteiro, M.C.; González-Menéndez, V.; Tormo, J.R.; Genilloud, O.; Bills, G.F.; Vicente, F.; et al. "Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola". Journal of Natural Products 78 3 (2015): 468-475. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925934767&partnerID=MN8TOARS.
    10.1021/np500854j
  137. Valiante, V.; Monteiro, M.C.; Martín, J.; Altwasser, R.; Aouad, N.E.; González, I.; Kniemeyer, O.; et al. "Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010)". Antimicrobial Agents and Chemotherapy 59 9 (2015): 5145-5153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940910954&partnerID=MN8TOARS.
    10.1128/AAC.00683-15
  138. Molina-Guijarro JM; García C; Macías Á; García-Fernández LF; Moreno C; Reyes F; Martínez-Leal JF; et al. "Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death.". (2015): http://europepmc.org/abstract/med/26474061.
    10.1371/journal.pone.0140782
  139. Cautain B; de Pedro N; Schulz C; Pascual J; da S Sousa T; Martin J; Pérez-Victoria I; et al. "Identification of the Lipodepsipeptide MDN-0066, a Novel Inhibitor of VHL/HIF Pathway Produced by a New Pseudomonas Species.". (2015): http://europepmc.org/abstract/med/26018559.
    10.1371/journal.pone.0125221
  140. Guimarães LA; Jimenez PC; Sousa Tda S; Freitas HP; Rocha DD; Wilke DV; Martín J; et al. "Chromomycin A2 induces autophagy in melanoma cells.". (2014): http://europepmc.org/abstract/med/25486109.
    10.3390/md12125839
  141. Martín-Rodríguez AJ; Reyes F; Martín J; Pérez-Yépez J; León-Barrios M; Couttolenc A; Espinoza C; et al. "Inhibition of bacterial quorum sensing by extracts from aquatic fungi: first report from marine endophytes.". (2014): http://europepmc.org/abstract/med/25415350.
    10.3390/md12115503
  142. González-Menéndez V; Asensio F; Moreno C; de Pedro N; Monteiro MC; de la Cruz M; Vicente F; et al. "Assessing the effects of adsorptive polymeric resin additions on fungal secondary metabolite chemical diversity.". (2014): http://europepmc.org/abstract/med/25379340.
    10.1080/21501203.2014.942406
  143. Coello, L.; Reyes, F.; Martín, M. J.; Cuevas, C.; Fernández, R.. "Isolation and Structures of Pipecolidepsins A and B, Cytotoxic Cyclic Depsipeptides from the Madagascan Sponge Homophymia lamellosa". J Nat Prod 77 2 (2014): 298-303.
    10.1021/np400888e
  144. Martin, M. J.; Rodriguez-Acebes, R.; Garcia-Ramos, Y.; Martinez, V.; Murcia, C.; Digon, I.; Marco, I.; et al. "Stellatolides, a New Cyclodepsipeptide Family from the Sponge Ecionemia acervus. Isolation, Solid-phase Total Synthesis and Full Structural Assignment of Stellatolide A". J Am Chem Soc (2014):
    10.1021/ja502744a
  145. Murcia, C.; Coello, L.; Fernández, R.; Martín, M. J.; Reyes, F.; Francesch, A.; Munt, S.; Cuevas, C.. "Tanjungides A and B: new antitumoral bromoindole derived compounds from Diazona cf formosa. isolation and total synthesis". Mar Drugs 12 2 (2014): 1116-30.
    10.3390/md12021116
  146. Almeida, C.; El Aouad, N.; Martín, J.; Pérez-Victoria, I.; González-Menéndez, V.; Platas, G.; de la Cruz, M.; et al. "Graminin B, a furanone from the fungus Paraconiothyrium sp". J Antibiot (Tokyo) (2014):
    10.1038/ja.2014.11
  147. Lacret R; Oves-Costales D; Gómez C; Díaz C; de la Cruz M; Pérez-Victoria I; Vicente F; Genilloud O; Reyes F. "New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis.". (2014): http://europepmc.org/abstract/med/25551780.
    10.3390/md13010128
  148. Montiel, R; Martin-Cabrejas, I; Langa, S; El Aouad, N; Arques, J L; Reyes, F; Medina, M. "Antimicrobial activity of reuterin produced by Lactobacillus reuteri on Listeria monocytogenes in cold-smoked salmon.". Food microbiology 44 (2014): 1-5.
    10.1016/j.fm.2014.05.006
  149. Pascual, Javier; Garcia-Lopez, Marina; Carmona, Cristina; Sousa, Thiciana da S; de Pedro, Nuria; Cautain, Bastien; Martin, Jesus; et al. "Pseudomonas soli sp. nov., a novel producer of xantholysin congeners.". Systematic and applied microbiology 37 6 (2014): 412-6.
    10.1016/j.syapm.2014.07.003
  150. Cautain, Bastien; de Pedro, Nuria; Murillo Garzón, Virginia; Muñoz de Escalona, María; González Menéndez, Victor; Tormo, José R.; Martin, Jesús; et al. "High-Content Screening of Natural Products Reveals Novel Nuclear Export Inhibitors". Journal of Biomolecular Screening 19 1 (2014): 57-65.
    10.1177/1087057113501389
  151. Martín, J.; Crespo, G.; González-Menéndez, V.; Pérez-Moreno, G.; Sánchez-Carrasco, P.; Pérez-Victoria, I.; Ruiz-Pérez, L. M.; et al. "MDN-0104, an Antiplasmodial Betaine Lipid from Heterospora chenopodii". J Nat Prod (2014):
    10.1021/np500577v
  152. Audoin, Coralie; Bonhomme, Dominique; Ivanisevic, Julijana; Cruz, Mercedes de la; Cautain, Bastien; Monteiro, Maria Candida; Reyes, Fernando; et al. "Balibalosides, an Original Family of Glucosylated Sesterterpenes Produced by the Mediterranean Sponge Oscarella balibaloi.". Marine drugs 11 5 (2013): 1477-89.
    10.3390/md11051477
  153. Martin, Jesus; Sousa, Thiciana da S.; Crespo, Gloria; Palomo, Sara; Gonzalez, Ignacio; Tormo, Jose R.; de la Cruz, Mercedes; et al. "Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris". Marine Drugs 11 2 (2013): 387-398.
    10.3390/md11020387
  154. Palomo, Sara; Gonzalez, Ignacio; de la Cruz, Mercedes; Martin, Jesus; Ruben Tormo, Jose; Anderson, Matthew; Hill, Russell T.; et al. "Sponge-Derived Kocuria and Micrococcus spp. as Sources of the New Thiazolyl Peptide Antibiotic Kocurin". Marine Drugs 11 4 (2013): 1071-1086.
    10.3390/md11041071
  155. Martin, M. J.; Coello, L.; Fernandez, R.; Reyes, F.; Rodriguez, A.; Murcia, C.; Garranzo, M.; et al. "Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds". Journal of the American Chemical Society 135 27 (2013): 10164-10171.
    10.1021/ja404578u
  156. Singh, Sheo B.; Ondeyka, John; Harris, Guy; Herath, Kithsiri; Zink, Deborah; Vicente, Francisca; Bills, Gerald; et al. "Isolation, Structure, and Biological Activity of Phaeofungin, a Cyclic Lipodepsipeptide from a Phaeosphaeria sp Using the Genome-Wide Candida albicans Fitness Test". Journal of Natural Products 76 3 (2013): 334-345.
    10.1021/np300704s
  157. de la Cruz, Mercedes; Martin, Jesus; Gonzalez-Menendez, Victor; Perez-Victoria, Ignacio; Moreno, Catalina; Ruben Tormo, Jose; El Aouad, Noureddine; et al. "Chemical and Physical Modulation of Antibiotic Activity in Emericella Species". Chemistry & Biodiversity 9 6 (2012): 1095-1113.
    10.1002/cbdv.201100362
  158. Perez-Victoria, Ignacio; Martin, Jesus; Gonzalez-Menendez, Victor; de Pedro, Nuria; El Aouad, Noureddine; Javier Ortiz-Lopez, Francisco; Ruben Tormo, Jose; et al. "Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola sclerotica". Journal of Natural Products 75 6 (2012): 1210-1214.
    10.1021/np3000987
  159. El Aouad, Noureddine; Perez-Moreno, Guiomar; Sanchez, Paula; Cantizani, Juan; Javier Ortiz-Lopez, Francisco; Martin, Jesus; Gonzalez-Menendez, Victor; et al. "Lasionectrin, a Naphthopyrone from a Lasionectria sp.". Journal of Natural Products 75 6 (2012): 1228-1230.
    10.1021/np3002942
  160. Schleissner, Carmen; Perez, Marta; Losada, Alejandro; Rodriguez, Pilar; Crespo, Cristina; Zuniga, Paz; Fernandez, Rogelio; Reyes, Fernando; de la Calle, Fernando. "Antitumor Actinopyranones Produced by Streptomyces albus POR-04-15-053 Isolated from a Marine Sediment". Journal of Natural Products 74 7 (2011): 1590-1596.
    10.1021/np200196j
  161. Reyes, Fernando; Rodriguez-Acebes, Raquel; Fernandez, Rogelio; Bueno, Santiago; Francesch, Andres; Cuevas, Carmen. "Stolonoxides E and F, Cytotoxic Metabolites from the Marine Ascidian Stolonica socialis". Journal of Natural Products 73 1 (2010): 83-85.
    10.1021/np900700h
  162. Jesus Martin, Maria; Fernandez, Rogelio; Francesch, Andres; Amade, Philippe; de Matos-Pita, Susana S.; Reyes, Fernando; Cuevas, Carmen. "Plumisclerin A, a Diterpene with a New Skeleton from the Soft Coral Plumigorgia terminosclera". Organic Letters 12 5 (2010): 912-914.
    10.1021/ol902802h
  163. Laville, Remi; Genta-Jouve, Gregory; Urda, Carlos; Fernandez, Rogelio; Thomas, Olivier P.; Reyes, Fernando; Amade, Philippe. "Njaoaminiums A, B, and C: Cyclic 3-Alkylpyridinium Salts from the Marine Sponge Reniera sp.". Molecules 14 11 (2009): 4716-4724.
    10.3390/molecules14114716
  164. Perez, Marta; Crespo, Cristina; Schleissner, Carmen; Rodriguez, Pilar; Zuniga, Paz; Reyes, Fernando. "Tartrolon D, a Cytotoxic Macrodiolide from the Marine-Derived Actinomycete Streptomyces sp MDG-04-17-069". Journal of Natural Products 72 12 (2009): 2192-2194.
    10.1021/np9006603
  165. Coello, Laura; Jesus Martin, Maria; Reyes, Fernando. "1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp.". Marine Drugs 7 3 (2009): 445-450.
    10.3390/md7030445
  166. Ciulli, A.; Scott, D.E.; Ando, M.; Reyes, F.; Saldanha, S.A.; Tuck, K.L.; Chirgadze, D.Y.; Blundell, T.L.; Abell, C.. "Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.". Chembiochem : a European journal of chemical biology 9 16 (2008): 2606-2611. http://www.scopus.com/inward/record.url?eid=2-s2.0-59449099151&partnerID=MN8TOARS.
  167. Fernandez, Rogelio; Martin, Maria Jesus; Rodriguez-Acebes, Raquel; Reyes, Fernando; Francesch, Andres; Cuevas, Carmen. "Diazonamides C-E, new cytotoxic metabolites from the ascidian Diazona sp.". Tetrahedron Letters 49 14 (2008): 2283-2285.
    10.1016/j.tetlet.2008.02.012
  168. Reyes, Fernando; Fernandez, Rogelio; Rodriguez, Alberto; Francesch, Andres; Taboada, Sergi; Avila, Conxita; Cuevas, Carmen. "Aplicyanins A-F, new cytotoxic bromoindole derivatives from the marine tunicate Aplidium cyaneum". Tetrahedron 64 22 (2008): 5119-5123.
    10.1016/j.tet.2008.03.060
  169. Reyes, Fernando; Fernandez, Rogelio; Rodriguez, Alfredo; Bueno, Santiago; de Eguilior, Carlos; Francesch, Andres; Cuevas, Carmen. "Cytotoxic staurosporines from the marine ascidian Cystodytes solitus". Journal of Natural Products 71 6 (2008): 1046-1048.
    10.1021/np700748h
  170. Jesus Poza, Javier; Fernandez, Rogelio; Reyes, Fernando; Rodriguez, Jaime; Jimenez, Carlos. "Isolation, biological significance, synthesis, and cytotoxic evaluation of new natural parathiosteroids A-C and analogues from the soft coral Paragorgia sp.". Journal of Organic Chemistry 73 20 (2008): 7978-7984.
    10.1021/jo801198u
  171. Laville, Remi; Thomas, Olivier P.; Berrue, Fabrice; Reyes, Fernando; Amade, Philippe. "Pachychalines A-C: Novel 3-alkylpyridinium salts from the marine sponge Pachychalina sp.". European Journal of Organic Chemistry 1 (2008): 121-125.
    10.1002/ejoc.200700741
  172. Avalos, J.; Cerda-Olmedo, E.; Reyes, F.; Barrero, A. F.. "Gibberellins and other metabolites of Fusarium fujikuroi and related fungi". Current Organic Chemistry 11 8 (2007): 721-737.
    10.2174/138527207780598729
  173. Reyes, Fernando; Fernandez, Rogelio; Urda, Carlos; Francesch, Andres; Bueno, Santiago; de Eguilior, Carlos; Cuevas, Carmen. "Njaoamines A-F, new cytotoxic polycyclic alkaloids from the haplosclerid sponge Reniera sp.". Tetrahedron 63 11 (2007): 2432-2438.
    10.1016/j.tet.2007.01.013
  174. Rueda, A.; Losada, A.; Fernández, R.; Cabañas, C.; García-Fernández, L.F.; Reyes, F.; Cuevas, C.. "Gracilins G-I, cytotoxic bisnorditerpenes from Spongionella pulchella, and the anti-adhesive properties of Gracilin B". Letters in Drug Design and Discovery 3 10 (2006): 753-760. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846059946&partnerID=MN8TOARS.
    10.2174/157018006778631875
  175. Sorek, Hagit; Rudi, Amira; Gueta, Sophie; Reyes, Fernando; Martin, Maria Jesus; Aknin, Maurice; Gaydou, Emile; Vacelet, Jean; Kashman, Yoel. "Netamines A-G: seven new tricyclic guanidine alkaloids from the marine sponge Biemna laboutei". Tetrahedron 62 37 (2006): 8838-8843.
    10.1016/j.tet.2006.06.063
  176. Montalvo, D; Amade, P; Funel-Le Bon, C; Fernandez, R; Reyes, F. "Acerolide, a new cytotoxic cembranolide from the soft coral Pseudopterogorgia acerosa". Natural Product Research 20 6 (2006): 548-552.
    10.1080/14786410500183274
  177. Reyes, F; Martin, R; Fernandez, R. "Granulatamides A and B, cytotoxic tryptamine derivatives from the soft coral Eunicella granulata". Journal of Natural Products 69 4 (2006): 668-670.
    10.1021/np050382s
  178. Martin, MJ; Berrue, F; Amade, P; Fernandez, R; Francesch, A; Reyes, F; Cuevas, C. "Halogenated helianane derivatives from the sponge Spirastrella hartmani". Journal of Natural Products 68 10 (2005): 1554-1555.
    10.1021/np050247f
  179. Berrue, F; Thomas, OP; Bon, CFL; Reyes, F; Amade, P. "New bioactive cyclic peroxides from the Caribbean marine sponge Plakortis zyggompha". Tetrahedron 61 50 (2005): 11843-11849.
    10.1016/j.tet.2005.09.077
  180. Bon, CFL; Berrue, F; Thomas, OP; Reyes, F; Amade, P. "Sodwanone S, a triterpene from the marine sponge Axinella weltneri". Journal of Natural Products 68 8 (2005): 1284-1287.
    10.1021/np050100o
  181. Reyes, F; Arda, A; Martin, R; Fernandez, R; Rueda, A; Montalvo, D; Gomez, C; et al. "New cytotoxic cembranes from the sea pen Gyrophyllum sibogae". Journal of Natural Products 67 7 (2004): 1190-1192.
    10.1021/np049903m
  182. Perez, M; del Pozo, C; Reyes, F; Rodriguez, A; Francesch, A; Echavarren, AM; Cuevas, C. "Total synthesis of natural myriaporones". Angewandte Chemie-International Edition 43 13 (2004): 1724-1727.
    10.1002/anie.200353313
  183. Reyes, F; Martin, R; Rueda, A; Fernandez, R; Montalvo, D; Gomez, C; Sanchez-Puelles, JM. "Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis". Journal of Natural Products 67 3 (2004): 463-465.
    10.1021/np0303761
  184. Vazquez, MJ; Roa, AM; Reyes, F; Vega, A; Rivera-Sagredo, A; Thomas, DR; Diez, E; Hueso-Rodriguez, JA. "A novel ergot alkaloid as a 5-HT1A inhibitor produced by Dicyma sp.". Journal of Medicinal Chemistry 46 24 (2003): 5117-5120.
    10.1021/jm0341204
  185. García-Fernández, L.F.; Reyes, F.; Sánchez-Puelles, J.M.. "The marine pharmacy: New antitumoral compounds from the sea". Pharmaceutical News 9 6 (2002): 495-501. http://www.scopus.com/inward/record.url?eid=2-s2.0-17944384236&partnerID=MN8TOARS.
  186. Barrero, AF; Oltra, JE; Cabrera, E; Reyes, F; Alvarez, M. "Metabolism of gibberellins and ent-kaurenoids in mutants of Gibberella fujikuroi". Phytochemistry 50 7 (1999): 1133-1140.
    10.1016/S0031-9422(98)00699-2
  187. Barrero, AF; Haidour, A; Reyes, F; Sedqui, A; Mansour, AI. "Monoterpene aldehydes from Bupleurum gibraltaricum". Journal of Natural Products 61 4 (1998): 506-507.
    10.1021/np960732y
  188. Ramos JL; Duque E; Rodríguez-Herva JJ; Godoy P; Haïdour A; Reyes F; Fernández-Barrero A. "Mechanisms for solvent tolerance in bacteria.". (1997): http://europepmc.org/abstract/med/9020089.
    10.1074/jbc.272.7.3887
  189. Fernández-Martín R; Reyes F; Domenech CE; Cabrera E; Bramley PM; Barrero AF; Avalos J; Cerdá-Olmedo E. "Gibberellin biosynthesis in gib mutants of Gibberella fujikuroi.". (1995): http://europepmc.org/abstract/med/7797477.
    10.1074/jbc.270.25.14970
  190. BARRERO, AF; OLTRA, JE; HERRADOR, MM; CABRERA, E; SANCHEZ, JF; QUILEZ, JF; ROJAS, FJ; REYES, JF. "GIBEPYRONES - ALPHA-PYRONES FROM GIBBERELLA-FUJIKUROI". Tetrahedron 49 1 (1993): 141-150.
    10.1016/S0040-4020(01)80514-7
  191. Barrero, A. F.; Oltra, J. E.; Cabrera, E.; Herrador, M. M.; Rojas, R. J.; Reyes, J. F.; Godoy, F.; Hypocreales,. "Gibelactol, A Diterpenoid From Gibberella Fujikuroi". Natural Product Letters 1 3 (1992): 155-160.
    10.1080/10575639208048905
  192. BARRERO, AF; SANCHEZ, JF; REYES, F; RODRIGUEZ, I. "RESORCINOL DERIVATIVES FROM ONONIS-VISCOSA". Phytochemistry 30 2 (1991): 641-643.
    10.1016/0031-9422(91)83743-5
Livro
  1. Martínez, G.; González-Menéndez, V.; Martín, J.; Reyes, F.; Genilloud, O.; Tormo, J.R.. MASS studio: A novel software utility to simplify LC-MS analyses of large sets of samples for metabolomics. 2017.
    10.1007/978-3-319-56148-6_20
  2. Cautain, B.; de Pedro, N.; Reyes, F.; Link, W.; Cautain B; de Pedro N; Reyes F; Link W. Image-based identification of nuclear export inhibitors from natural products. 2015.
    10.1007/978-1-4939-2309-0_22,
Poster em conferência
  1. Santos, José Diogo Neves; Inês Rosado Vitorino; Ignacio Gonzalez; José Ruben Tormo; Mercedes de la Cruz; Maria Carmen Ramos; Jesus Martin; et al. Autor correspondente: Santos, José Diogo Neves. "MARINE ACTINOMYCETOTA FROM PORTUGAL ARE SOURCES OF NOVEL NATURAL PRODUCTS". Trabalho apresentado em XIII European Congress on Marine Natural Products and XVII International Symposium on Marine Natural Products, 2023.
Pré-impressão
  1. Katerina Georgousaki; Nikolaos Tsafantakis; Ignacio Gonzalez; Jesús Martín; Thomas A. Mackenzie; Sentiljana Gumeni; Ioannis P. Trougakos; et al. "Isolation, Spectral Assignments and Absolute Configuration of a Linear Hexapeptide from the Culture Broth of the Plant-Associated Actinomycete Actinomycetospora sp. Ca-287887". 2025. https://doi.org/10.20944/preprints202501.1639.v1.
    10.20944/preprints202501.1639.v1

Outros

Outra produção
  1. Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity. 2023. Martínez-Arribas, B.; Annang, F.; Díaz-González, R.; Pérez-Moreno, G.; Martín, J.; Mackenzie, T.A.; Castillo, F.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85160336587&partnerID=MN8TOARS.
    10.1101/2023.04.20.537680
  2. Identification of the 216kbp gene cluster and structure elucidation of gargantulides B and C, new complex 52-membered macrolides from Amycolatopsis sp.. 2021. Carretero-Molina, D.; Ortiz-López, F.J.; Gren, T.; Oves-Costales, D.; Martín, J.; Román-Hurtado, F.; Jørgensen, T.S.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115731145&partnerID=MN8TOARS.
    10.1101/2021.08.11.455926
  3. Pentaminomycins F and G, First Non-Ribosomal Peptides Containing 2-Pyridylalanine. 2020. Daniel Carretero Molina; Francisco Javier Ortiz-Lopez; Jesús Martín; Ignacio González; Marina Sánchez-Hidalgo; Fernando Román-Hurtado; Caridad Díaz; et al. https://doi.org/10.26434/chemrxiv.13142786.
    10.26434/chemrxiv.13142786
  4. One pathway, two cyclic pentapeptides: heterologous expression of BE-18257 A-C and pentaminomycins A-E from Streptomyces cacaoi CA-170360. 2020. Fernando Román-Hurtado; Marina Sánchez-Hidalgo; Jesús Martín; Francisco Javier Ortiz-López; Daniel Carretero-Molina; Fernando Reyes; Olga Genilloud. https://doi.org/10.1101/2020.10.23.352575.
    10.1101/2020.10.23.352575
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2017/09/01 - 2024/06/14 Exploring the production, biological activity and preclinical safety of antimicrobial spirotetronates isolated from marine microorganisms
Coorientador
Universidad de Granada, Espanha
2019/10/01 - 2024/05/17 Searching marine bacteria for novel pharmaceutical leads
Coorientador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2017/06/01 - 2024/01/24 Expanding the chemical space of microbial specialized metabolites: structure elucidation and biosynthesis of novel bioactive natural products from actinomycetes
Coorientador
Pharmacy (Doutoramento)
Universidad de Granada, Espanha
2019/12/09 - 2020/12/02 Aislamiento de moléculas con actividad antifúngica frente a hongos fitopatógenos de interés
Coorientador
Máster en Investigación, Desarrollo, Control e Innovación de Medicamentos (Mestrado)
Universidad de Granada, Espanha
2014/01/01 - 2019/11/25 Compuestos relacionados con ramoplanina producidos por actinomicetos
Coorientador
Microbiology (Doutoramento)
Universidad Complutense de Madrid, Espanha
2018/12/10 - 2019/09/11 Análisis de extractos de hongos aislados de líquenes como fuente de moléculas bioactivas
Coorientador
Máster en Investigación, Desarrollo, Control e Innovación de Medicamentos (Mestrado)
Universidad de Granada, Espanha
2018/01/12 - 2018/09/12 Análisis de extractos de Actinomicetos como fuente de moléculas bioactivas
Orientador
Máster en investigación, desarrollo, control e innovación de medicamentos (Mestrado)
Universidad de Granada, Espanha
2017/01/01 - 2017/09/11 Aislamiento y caracterización estructural de productos naturales de actinomicetos marinos
Coorientador
Máster en Investigación, Desarrollo, Control e Innovación de Medicamentos (Mestrado)
Universidad de Granada, Espanha

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2023/09/03 - 2023/09/08 XIII European Conference on Marine Natural Products and XVII International Symposium on Marine Natural Products (2023/09/03 - 2023/09/08)
Conferência (Presidente da Comissão Organizadora)
Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Espanha