???global.info.a_carregar???
Branca Maria Prudêncio Limón Cavaco completed her degree in Biochemistry in 1992, from the Faculty of Sciences, University of Lisbon. She completed her PhD in 2002, at the Faculty of Sciences, University of Lisbon. She is a Researcher (career) at the Portuguese Institute of Oncology Francisco Gentil from Lisbon, EPE, were she develops her activity as Principal Investigator of the Molecular Endocrinology Group.
Identificação

Identificação pessoal

Nome completo
Branca Maria Prudêncio Limón Cavaco

Nomes de citação

  • Cavaco, Branca
  • Cavaco, B.M.
  • Cavaco, B.
  • Branca Maria Cavaco
  • Cavaco, Branca Maria

Identificadores de autor

Ciência ID
2317-7811-CC76
ORCID iD
0000-0001-8946-8635

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Genética Humana

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador independente (B2) Utilizador proficiente (C2)
Francês Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A2)
Produções

Publicações

Artigo em revista
  1. Pires, Carolina; Saramago, Ana; Moura, Margarida M.; Li, Jing; Donato, Sara; Marques, Inês J.; Belo, Hélio; et al. Autor correspondente: Cavaco, B.M.. "Identification of Germline FOXE1 and Somatic MAPK Pathway Gene Alterations in Patients with Malignant Struma Ovarii, Cleft Palate and Thyroid Cancer". International Journal of Molecular Sciences 25 4 (2024): 1966. http://dx.doi.org/10.3390/ijms25041966.
    Acesso aberto • Publicado • 10.3390/ijms25041966
  2. Pires, Carolina; Marques, Inês J.; Valério, Mariana; Saramago, Ana; Santo, Paulo E.; Santos, Sandra; Silva, Margarida; et al. Autor correspondente: Cavaco, B.M.. "CHEK2 germline variants identified in familial non-medullary thyroid cancer lead to impaired protein structure and function". Journal of Biological Chemistry (2024): 105767. http://dx.doi.org/10.1016/j.jbc.2024.105767.
    Acesso aberto • 10.1016/j.jbc.2024.105767
  3. Simões-Pereira, Joana; Saramago, Ana; Rodrigues, Ricardo; Pojo, Marta; Pires, Carolina; Horta, Mariana; López-Presa, Dolores; et al. "Clinical and molecular characterisation of metastatic papillary thyroid cancer according to radioiodine therapy outcomes". Endocrine (2023): http://dx.doi.org/10.1007/s12020-023-03633-y.
    10.1007/s12020-023-03633-y
  4. Pita, Jaime M.; Raspé, Eric; Coulonval, Katia; Decaussin-Petrucci, Myriam; Tarabichi, Maxime; Dom, Geneviève; Libert, Frederick; et al. "CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas". Frontiers in Endocrinology 14 (2023): http://dx.doi.org/10.3389/fendo.2023.1247542.
    10.3389/fendo.2023.1247542
  5. Pinto, Ana Teresa; Pojo, Marta; Rodrigues, Ricardo; Sousa, Diana Pacheco; Matthiesen, Rune; Carvalho, Ana Sofia; Beck, Hans C.; et al. "SPRY4 as a Potential Mediator of the Anti-Tumoral Role of Macrophages in Anaplastic Thyroid Cancer Cells". Cancers 15 17 (2023): 4387. http://dx.doi.org/10.3390/cancers15174387.
    10.3390/cancers15174387
  6. Sara Lomelino Pinheiro; Ana Saramago; Branca Maria Cavaco; Carmo Martins; Valeriano Leite; Tiago Nunes da Silva. "Clinical and molecular characterization of parathyroid carcinoma in multiple endocrine neoplasia type 1". Endocrine Connections (2023): https://doi.org/10.1530/EC-22-0479.
    10.1530/EC-22-0479
  7. Dias, Daniela; Damásio, Inês; Marques, Pedro; Simões, Helder; Rodrigues, Ricardo; Cavaco, Branca Maria; Leite, Valeriano. "Metastatic follicular thyroid cancer with a longstanding responsiveness to gemcitabine plus oxaliplatin". European Thyroid Journal 12 3 (2023): http://dx.doi.org/10.1530/etj-22-0227.
    10.1530/etj-22-0227
  8. Ana Figueiredo; A. Saramago; B. M. Cavaco; J. Simões-Pereira; V. Leite. "Familial parathyroid tumours-comparison of clinical profiles between syndromes". Journal of Endocrinological Investigation (2023): http://dx.doi.org/10.1007/s40618-023-02032-4.
    10.1007/s40618-023-02032-4
  9. Tiago Nunes da Silva; Ricardo Rodrigues; Ana Saramago; Carolina Pires; Miguel Rito; Mariana Horta; Carmo Martins; Valeriano Leite; Branca M Cavaco. "Target therapy for BRAF mutated anaplastic thyroid cancer: a clinical and molecular study". European Journal of Endocrinology 188 1 (2023): http://dx.doi.org/10.1093/ejendo/lvac011.
    10.1093/ejendo/lvac011
  10. Inês Lemos Damásio; Joana Simões-Pereira; Donato S; Horta M; Cavaco BM; Rito M; Gomes P; Leite V. "Entrectinib in the neoadjuvant setting of anaplastic thyroid cancer: a case report.". European thyroid journal (2022): https://doi.org/10.1530/ETJ-22-0179.
    10.1530/etj-22-0179
  11. Cunha, Clara; Pinheiro, Sara Lomelino; Donato, Sara; Tavares Bello, Carlos; Simões, Helder; Nunes Silva, Tiago; Prazeres, Susana; et al. "Parathyroid carcinoma: Single centre experience". Clinical Endocrinology (2022): http://dx.doi.org/10.1111/cen.14684.
    10.1111/cen.14684
  12. Padeira, G.; Cavaco, B.M; Virella, D.; Sá-Couto, H.; Afonso-Lopes, M.L.. "Clinical, Molecular Characterization and Long-Term Follow-Up of a Patient with Neonatal Severe Hyperparathyroidism". 53 (2022): 440-446. https://pjp.spp.pt/article/view/24480.
    Publicado
  13. Chaves, Carolina; Nunes da Silva, Tiago; Dias Pereira, Bernardo; Anselmo, João; Claro, Isabel; Cavaco, Branca M.; Saramago, Ana; Leite, Valeriano. "A case report of multiple endocrine neoplasia type 1 and autoimmune disease". Medicine 100 49 (2021): e28145. http://dx.doi.org/10.1097/md.0000000000028145.
    10.1097/md.0000000000028145
  14. Marques, Inês J.; Gomes, Inês; Pojo, Marta; Pires, Carolina; Moura, Margarida M.; Cabrera, Rafael; Santos, Catarina; et al. "Identification of SPRY4 as a Novel Candidate Susceptibility Gene for Familial Nonmedullary Thyroid Cancer". Thyroid 31 9 (2021): 1366-1375. http://dx.doi.org/10.1089/thy.2020.0290.
    10.1089/thy.2020.0290
  15. Simões-Pereira, Joana; C. Ferreira, Teresa; Limbert, Edward; Cavaco, Branca Maria; Leite, Valeriano. "Outcomes of Thyrotropin Alfa Versus Levothyroxine Withdrawal-Aided Radioiodine Therapy for Distant Metastasis of Papillary Thyroid Cancer". Thyroid (2021): http://dx.doi.org/10.1089/thy.2021.0013.
    10.1089/thy.2021.0013
  16. Simões-Pereira, Joana; Mourinho, Nádia; Ferreira, Teresa C; Limbert, Edward; Cavaco, Branca Maria; Leite, Valeriano. "Avidity and Outcomes of Radioiodine Therapy for Distant Metastasis of Distinct Types of Differentiated Thyroid Cancer". The Journal of Clinical Endocrinology & Metabolism 106 10 (2021): e3911-e3922. http://dx.doi.org/10.1210/clinem/dgab436.
    10.1210/clinem/dgab436
  17. Pires, Carolina; Marques, Inês Jorge; Dias, Daniela; Saramago, Ana; Leite, Valeriano; Cavaco, Branca Maria. "A pathogenic variant in CHEK2 shows a founder effect in Portuguese Roma patients with thyroid cancer". Endocrine 73 3 (2021): 588-597. http://dx.doi.org/10.1007/s12020-021-02660-x.
    10.1007/s12020-021-02660-x
  18. Pojo, Marta; Sofia Fargoso; Sidónia Santos; Patricia Machado; Branca Maria Cavaco; Fátima Vaz. "APOL2: A New Candidate Gene Associated with Hereditary Prostate Cancer". British Journal of Cancer Research 3 3 (2020): 401-406. https://makperiodicallibrary.com/britishjournalofcancerresearch/wp-content/uploads/2020/04/BJCR-152.pdf.
    Publicado
  19. Campos, Catarina; Fragoso, Sofia; Luís, Rafael; Pinto, Filipe; Brito, Cheila; Esteves, Susana; Pataco, Margarida; et al. "High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma". Genes 11 4 (2020): 403. http://dx.doi.org/10.3390/genes11040403.
    10.3390/genes11040403
  20. Moura, M. M.; Cabrera, R. A.; Esteves, S.; Cavaco, B. M.; Soares, P.; Leite, V.. "Correlation of molecular data with histopathological and clinical features in a series of 66 patients with medullary thyroid carcinoma". 3 3 (2020): 401-406.
    Publicado • 10.1007/s40618-020-01456-6
  21. Pinto, Ana T.; Pojo, Marta; Simões-Pereira, Joana; Roque, Ruben; Saramago, Ana; Roque, Lúcia; Martins, Carmo; et al. "Establishment and characterization of a new patient-derived anaplastic thyroid cancer cell line (C3948), obtained through fine-needle aspiration cytology". Endocrine 66 2 (2019): 288-300. http://dx.doi.org/10.1007/s12020-019-02009-5.
    10.1007/s12020-019-02009-5
  22. Sousa, Diana P.; Pojo, Marta; Pinto, Ana T.; Leite, Valeriano; Serra, Ana Teresa; Cavaco, Branca M.. "Nobiletin Alone or in Combination with Cisplatin Decreases the Viability of Anaplastic Thyroid Cancer Cell Lines". Nutrition and Cancer 72 2 (2019): 352-363. http://dx.doi.org/10.1080/01635581.2019.1634745.
    10.1080/01635581.2019.1634745
  23. Donato, Sara; Simões, Helder; Pinto, Ana Teresa; M. Cavaco, Branca; Leite, Valeriano. "SDHx-related pheochromocytoma/paraganglioma – genetic, clinical, and treatment outcomes in a series of 30 patients from a single center". Endocrine 65 2 (2019): 408-415. http://dx.doi.org/10.1007/s12020-019-01953-6.
    10.1007/s12020-019-01953-6
  24. Lopes-Ventura, S.; Pojo, M.; Matias, A. T.; Moura, M. M.; Marques, I. J.; Leite, V.; Cavaco, B. M.. "The efficacy of HRAS and CDK4/6 inhibitors in anaplastic thyroid cancer cell lines". Journal of Endocrinological Investigation 42 5 (2018): 527-540. http://dx.doi.org/10.1007/s40618-018-0947-4.
    10.1007/s40618-018-0947-4
  25. Simões-Pereira, J.; Moura, M. M.; Marques, I. J.; Rito, M.; Cabrera, R. A.; Leite, V.; Cavaco, B. M.. "The role of EIF1AX in thyroid cancer tumourigenesis and progression". Journal of Endocrinological Investigation 42 3 (2018): 313-318. http://dx.doi.org/10.1007/s40618-018-0919-8.
    10.1007/s40618-018-0919-8
  26. Cavaco, Branca M; Canaff, Lucie; Nolin-Lapalme, Alexis; Vieira, Margarida; Silva, Tiago N; Saramago, Ana; Domingues, Rita; et al. "Homozygous Calcium-Sensing Receptor Polymorphism R544Q Presents as Hypocalcemic Hypoparathyroidism". The Journal of Clinical Endocrinology & Metabolism 103 8 (2018): 2879-2888. http://dx.doi.org/10.1210/jc.2017-02407.
    10.1210/jc.2017-02407
  27. Cavaco, B.M.. "Identification of a novel CTR9 germline mutation in a family with Wilms tumor". (2018):
    10.1016/j.ejmg.2017.12.010
  28. Cavaco, B.M.. "Genomic profiling reveals mutational landscape in parathyroid carcinomas". (2017):
    10.1172/jci.insight.92061
  29. Marques, I.J.; Moura, M.M.; Cabrera, R.; Pinto, A.E.; Simões-Pereira, J.; Santos, C.; Menezes, F.D.; et al. "Identification of somatic TERT promoter mutations in familial nonmedullary thyroid carcinomas". Clinical Endocrinology 87 4 (2017): 394-399. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020539300&partnerID=MN8TOARS.
    10.1111/cen.13375
  30. Pereira, J.S.; da Silva, J.G.; Tomaz, R.A.; Pinto, A.E.; Bugalho, M.J.; Leite, V.; Cavaco, B.M.. "Identification of a novel germline FOXE1 variant in patients with familial non-medullary thyroid carcinoma (FNMTC)". Endocrine 49 1 (2015): 204-214. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938342196&partnerID=MN8TOARS.
    10.1007/s12020-014-0470-0
  31. Yu, W.; McPherson, J.R.; Stevenson, M.; Van Eijk, R.; Heng, H.L.; Newey, P.; Gan, A.; et al. "Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion". Journal of Clinical Endocrinology and Metabolism 100 2 (2015): E360-E364. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927566019&partnerID=MN8TOARS.
    10.1210/jc.2014-3238
  32. Silva, A.L.; Carmo, F.; Moura, M.M.; Domingues, R.; Espadinha, C.; Leite, V.; Cavaco, B.; Bugalho, M.J.. "Identification and characterization of two novel germline RET variants associated with medullary thyroid carcinoma". Endocrine 49 2 (2015): 366-372. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929947736&partnerID=MN8TOARS.
    10.1007/s12020-015-0559-0
  33. Moura, M.M.; Cavaco, B.M.; Leite, V.. "RAS proto-oncogene in medullary thyroid carcinoma". Endocrine-Related Cancer 22 5 (2015): R235-R252. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942103878&partnerID=MN8TOARS.
    10.1530/ERC-15-0070
  34. Cavaco, B.M.. "Novel Mutation in the CASR Gene (p.Leu123Ser) in a Case of Autosomal Dominant Hypocalcemia". (2015):
    10.1055/s-0035-1554979
  35. Pita, J.M.; Figueiredo, I.F.; Moura, M.M.; Leite, V.; Cavaco, B.M.. "Cell cycle deregulation and TP53 and RAS mutations are major events in poorly differentiated and undifferentiated thyroid carcinomas". Journal of Clinical Endocrinology and Metabolism 99 3 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84895822573&partnerID=MN8TOARS.
    10.1210/jc.2013-1512
  36. Pinto, A.E.; Silva, G.L.; Henrique, R.; Menezes, F.D.; Teixeira, M.R.; Leite, V.; Cavaco, B.M.. "Familial vs sporadic papillary thyroid carcinoma: A matched-case comparative study showing similar clinical/prognostic behaviour". European Journal of Endocrinology 170 2 (2014): 321-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893700531&partnerID=MN8TOARS.
    10.1530/EJE-13-0865
  37. Melo, M.; Da Rocha, A.G.; Vinagre, J.; Batista, R.; Peixoto, J.; Tavares, C.; Celestino, R.; et al. "TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas". Journal of Clinical Endocrinology and Metabolism 99 5 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899908886&partnerID=MN8TOARS.
    10.1210/jc.2013-3734
  38. Marques, P.; Santos, R.; Cavaco, B.; Leite, V.. "Chronic hypocalcemia due to anti-calcium sensing receptor antibodies | Hipocalcemia crónica por anticorpos anti-recetor do cálcio". Acta Medica Portuguesa 27 3 (2014): 399-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903764956&partnerID=MN8TOARS.
  39. Cavaco, B.M.. "Regulation of calcium metabolism in pseudohypoparathyroidism type 1b. From genotype to physiopathologyRegulação do metabolismo do cálcio em pseudohipoparatiroidismo de tipo 1b. Do genótipo à fisiopatologia". (2014):
    doi.org/10.1016/j.rpedm.2014.05.002
  40. Limbert, E.; Prazeres, S.; São Pedro, M.; Madureira, D.; Miranda, A.; Ribeiro, M.; Carrilho, F.; et al. "Iodine intake in Portuguese school children | Aporte do Iodo nas Crianças das Escolas em Portugal". Acta Medica Portuguesa 25 1 (2012): 29-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865179915&partnerID=MN8TOARS.
  41. Domingues, R.; Tomaz, R.A.; Martins, C.; Nunes, C.; Bugalho, M.J.; Cavaco, B.M.. "Identification of the first germline HRPT2 whole-gene deletion in a patient with primary hyperparathyroidism". Clinical Endocrinology 76 1 (2012): 33-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-83455163973&partnerID=MN8TOARS.
    10.1111/j.1365-2265.2011.04184.x
  42. Tomaz, R.A.; Sousa, I.; Silva, J.G.; Santos, C.; Teixeira, M.R.; Leite, V.; Cavaco, B.M.. "FOXE1 polymorphisms are associated with familial and sporadic nonmedullary thyroid cancer susceptibility". Clinical Endocrinology 77 6 (2012): 926-933. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869040208&partnerID=MN8TOARS.
    10.1111/j.1365-2265.2012.04505.x
  43. Cavaco, B.M.; Santos, R.; Félix, A.; Carvalho, D.; Lopes, J.M.; Domingues, R.; Sirgado, M.; et al. "Identification of de novo germline mutations in the HRPT2 gene in two apparently sporadic cases with challenging parathyroid tumor diagnoses". Endocrine Pathology 22 1 (2011): 44-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953284330&partnerID=MN8TOARS.
    10.1007/s12022-011-9151-1
  44. Moura, M.M.; Cavaco, B.M.; Pinto, A.E.; Leite, V.. "High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas". Journal of Clinical Endocrinology and Metabolism 96 5 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79955669404&partnerID=MN8TOARS.
    10.1210/jc.2010-1921
  45. Tomaz, R.A.; Cavaco, B.M.; Leite, V.. "Differential methylation as a cause of allele dropout at the imprinted GNAS locus". Genetic Testing and Molecular Biomarkers 14 4 (2010): 455-460. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955881209&partnerID=MN8TOARS.
    10.1089/gtmb.2010.0029
  46. Cavaco, B.M.; Tomaz, R.A.; Fonseca, F.; Mascarenhas, M.R.; Leite, V.; Sobrinho, L.G.. "Clinical and genetic characterization of Portuguese patients with pseudohypoparathyroidism type Ib". Endocrine 37 3 (2010): 408-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952092694&partnerID=MN8TOARS.
    10.1007/s12020-010-9321-9
  47. Moura, M.M.; Cavaco, B.M.; Pinto, A.E.; Domingues, R.; Santos, J.R.; Cid, M.O.; Bugalho, M.J.; Leite, V.. "Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas". British Journal of Cancer 100 11 (2009): 1777-1783. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349168712&partnerID=MN8TOARS.
    10.1038/sj.bjc.6605056
  48. Pita, J.M.; Banito, A.; Cavaco, B.M.; Leite, V.. "Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas". British Journal of Cancer 101 10 (2009): 1782-1791. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449519393&partnerID=MN8TOARS.
    10.1038/sj.bjc.6605340
  49. Oliveira, M.J.; Rodrigues, F.; Pereiras, C.; Borges, F.; Carrilho, F.; Limbert, E.; Jácome De Castro, J.; et al. "Treatment of differentiated thyroid carcinoma: A survey | Encuesta sobre el tratamiento del carcinoma diferenciado de tiroides". Endocrinologia y Nutricion 55 7 (2008): 283-288. http://www.scopus.com/inward/record.url?eid=2-s2.0-51849141365&partnerID=MN8TOARS.
    10.1016/S1575-0922(08)72182-X
  50. Cavaco, B.M.; Batista, P.F.; Martins, C.; Banito, A.; Do Rosário, F.; Limbert, E.; Sobrinho, L.G.; Leite, V.. "Familial non-medullary thyroid carcinoma (FNMTC): Analysis of fPTC/PRN, NMTC1, MNG1 and TCO susceptibility loci and identification of somatic BRAF and RAS mutations". Endocrine-Related Cancer 15 1 (2008): 207-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-41349093968&partnerID=MN8TOARS.
    10.1677/ERC-07-0214
  51. Cavaco, B.M.; Batista, P.F.; Sobrinho, L.G.; Leite, V.. "Mapping a new familial thyroid epithelial neoplasia susceptibility locus to chromosome 8p23.1-p22 by high-density single-nucleotide polymorphism genome-wide linkage analysis". Journal of Clinical Endocrinology and Metabolism 93 11 (2008): 4426-4430. http://www.scopus.com/inward/record.url?eid=2-s2.0-57349123714&partnerID=MN8TOARS.
    10.1210/jc.2008-0449
  52. Machado, P.M.; Cavaco, B.M.; Brandão, R.; Eugénio, J.; Santos, S.; Opinião, A.; Vaz, F.. "In reply [2]". Journal of Clinical Oncology 25 31 (2007): 5036-5038. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849059259&partnerID=MN8TOARS.
    10.1200/JCO.2007.13.5442
  53. Espadinha, C.; Cavaco, B.M.; Leite, V.. "PAX8PPAR¿ stimulates cell viability and modulates expression of thyroid-specific genes in a human thyroid cell line". Thyroid 17 6 (2007): 497-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447532041&partnerID=MN8TOARS.
    10.1089/thy.2006.0263
  54. Machado, P.M.; Brandão, R.D.; Cavaco, B.M.; Eugénio, J.; Bento, S.; Nave, M.; Rodrigues, P.; Fernandes, A.; Vaz, F.. "Screening for a BRCA2 rearrangement in high-risk breast/ovarian cancer families: Evidence for a founder effect and analysis of the associated phenotypes". Journal of Clinical Oncology 25 15 (2007): 2027-2034. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249932412&partnerID=MN8TOARS.
    10.1200/JCO.2006.06.9443
  55. Bradley, K.J.; Cavaco, B.M.; Bowl, M.R.; Harding, B.; Cranston, T.; Fratter, C.; Besser, G.M.; et al. "Parafibromin mutations in hereditary hyperparathyroidism syndromes and parathyroid tumours". Clinical Endocrinology 64 3 (2006): 299-306. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644943454&partnerID=MN8TOARS.
    10.1111/j.1365-2265.2006.02460.x
  56. Sancho, M.; Vieira, J.M.; Casalou, C.; Mesquita, M.; Pereira, T.; Cavaco, B.M.; Dias, S.; Leite, V.. "Expression and function of the chemokine receptor CCR7 in thyroid carcinomas". Journal of Endocrinology 191 1 (2006): 229-238. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751047440&partnerID=MN8TOARS.
    10.1677/joe.1.06688
  57. Bradley, K.J.; Cavaco, B.M.; Bowl, M.R.; Harding, B.; Young, A.; Thakker, R.V.. "Utilisation of a cryptic non-canonical donor splice site of the gene encoding PARAFIBROMIN is associated with familial isolated primary hyperparathyroidism.". Journal of medical genetics. 42 8 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-33644937809&partnerID=MN8TOARS.
  58. Bradley, K.J.; Hobbs, M.R.; Buley, I.D.; Carpten, J.D.; Cavaco, B.M.; Fares, J.E.; Laidler, P.; et al. "Uterine tumours are a phenotypic manifestation of the hyperparathyroidism- jaw tumour syndrome". Journal of Internal Medicine 257 1 (2005): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-19944434120&partnerID=MN8TOARS.
    10.1111/j.1365-2796.2004.01421.x
  59. Vieira, J.M.; Rosa Santos, S.C.; Espadinha, C.; Correia, I.; Vag, T.; Casalou, C.; Cavaco, B.M.; et al. "Expression of vascular endothelial growth factor (VEGF) and its receptors in thyroid carcinomas of follicular origin: A potential autocrine loop". European Journal of Endocrinology 153 5 (2005): 701-709. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944499811&partnerID=MN8TOARS.
    10.1530/eje.1.02009
  60. Martins, C.; Cavaco, B.; Tonon, G.; Kaye, F.J.; Soares, J.; Fonseca, I.. "A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands". Journal of Molecular Diagnostics 6 3 (2004): 205-210. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344671950&partnerID=MN8TOARS.
    10.1016/S1525-1578(10)60511-9
  61. Cavaco, B.M.; Guerra, L.; Bradley, K.J.; Carvalho, D.; Harding, B.; Oliveira, A.; Santos, M.-A.; et al. "Hyperparathyroidism-jaw tumor syndrome in Roma families from Portugal is due to a founder mutation of the HRPT2 gene". Journal of Clinical Endocrinology and Metabolism 89 4 (2004): 1747-1752. http://www.scopus.com/inward/record.url?eid=2-s2.0-11144355570&partnerID=MN8TOARS.
    10.1210/jc.2003-031016
  62. Cavaco, B.M.; Torrinha, F.; Mendonça, E.; Pratas, S.; Boavida, J.; Sobrinho, L.G.; Leite, V.. "Preoperative diagnosis of suspicious parathyroid adenomas by RT-PCR using mRNA extracted from left-over cells in a needle used for ultrasonically guided fine needle aspiration cytology". Acta Cytologica 47 1 (2003): 5-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037267594&partnerID=MN8TOARS.
    10.1159/000326468
  63. Pannett, A.A.J.; Kennedy, A.M.; Turner, J.J.O.; Forbes, S.A.; Cavaco, B.M.; Bassett, J.H.D.; Cianferotti, L.; et al. "Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism". Clinical Endocrinology 58 5 (2003): 639-646. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038332150&partnerID=MN8TOARS.
    10.1046/j.1365-2265.2003.01765.x
  64. Moniz, S.; Catarino, A.L.; Marques, A.R.; Cavaco, B.; Sobrinho, L.; Leite, V.. "Clonal origin of non-medullary thyroid tumours assessed by non-random X-chromosome inactivation". European Journal of Endocrinology 146 1 (2002): 27-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036161594&partnerID=MN8TOARS.
    10.1530/eje.0.1460027
  65. Carpten, J.D.; Robbins, C.M.; Villablanca, A.; Forsberg, L.; Presciuttini, S.; Bailey-Wilsons, J.; Simonds, W.F.; et al. "HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome". Nature Genetics 32 4 (2002): 676-680. http://www.scopus.com/inward/record.url?eid=2-s2.0-18744385803&partnerID=MN8TOARS.
    10.1038/ng1048
  66. Cavaco, B.M.; Domingues, R.; Bacelar, M.C.; Cardoso, H.; Barros, L.; Gomes, L.; Ruas, M.M.A.; et al. "Mutational analysis of Portuguese families with multiple endocrine neoplasia type 1 reveals large germline deletions". Clinical Endocrinology 56 4 (2002): 465-473. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036232062&partnerID=MN8TOARS.
    10.1046/j.1365-2265.2002.01505.x
  67. Cavaco, B.M.; Barros, L.; Pannett, A.A.J.; Ruas, L.; Carvalheiro, M.; Ruas, M.M.A.; Krausz, T.; et al. "The hyperparathyroidism-jaw tumour syndrome in a Portuguese kindred". QJM - Monthly Journal of the Association of Physicians 94 4 (2001): 213-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035060663&partnerID=MN8TOARS.
  68. Cavaco, B.; Uchigata, Y.; Porto, T.; Amparo-Santos, M.; Sobrinho, L.; Leite, V.. "Hypoglycaemia due to insulin autoimmune syndrome: Report of two cases with characterization of HLA alleles and insulin autoantibodies". European Journal of Endocrinology 145 3 (2001): 311-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034852122&partnerID=MN8TOARS.
  69. Marques, A.R.; Catarino, A.L.; Moniz, S.; Cavaco, B.; Roque, L.; Sobrinho, L.; Leite, V.. "Medullary carcinomas of the thyroid: A monoclonal origin". Thyroid 11 12 (2001): 1109-1113. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035671228&partnerID=MN8TOARS.
    10.1089/10507250152740948
  70. Cavaco, B.; Leite, V.; Loureiro, M.M.; Ferreira, M.F.; Pereira, M.C.; Santos, M.A.; Sobrinho, L.G.. "Spontaneously occurring anti-PTH autoantibodies must be considered in the differential diagnosis of patients with elevated serum PTH levels". Journal of Endocrinological Investigation 22 11 (1999): 829-834. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033389768&partnerID=MN8TOARS.
  71. Williamson, C.; Cavaco, B.M.; Jausch, A.; Dixon, P.H.; Forbes, S.; Harding, B.; Holtgreve-Grez, H.; et al. "Mapping the gene causing hereditary primary hyperparathyroidism in a Portuguese kindred to chromosome 1q22-q31". Journal of Bone and Mineral Research 14 2 (1999): 230-239. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032899239&partnerID=MN8TOARS.
    10.1359/jbmr.1999.14.2.230
  72. Cavaco, B.; Prazeres, S.; Santos, M.A.; Sobrinho, L.G.; Leite, V.. "Hyperprolactinemia due to big big prolactin is differently detected by commercially available immunoassays". Journal of Endocrinological Investigation 22 3 (1999): 203-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032898897&partnerID=MN8TOARS.
    10.1007/BF03343542
  73. Williamson, C.; Cavaco, B.M.; Jauch, A.; Dixon, P.H.; Forbes, S.; Harding, B.; Holtgreve-Grez, H.; et al. "Erratum: Mapping the gene causing hereditary primary hyperparathyroidism in a Portuguese kindred to chromosome 1q22-q31 (Journal of Bone and Mineral Research (February 1999) 14 (230-239))". Journal of Bone and Mineral Research 14 8 (1999): http://www.scopus.com/inward/record.url?eid=2-s2.0-0032772766&partnerID=MN8TOARS.
  74. Cavaco, B.; Leite, V.; Santos, M.A.; Arranhado, E.; Sobrinho, L.G.. "Some forms of big big prolactin behave as a complex of monomeric prolactin with an immunoglobulin G in patients with macroprolactinemia or prolactinoma". Journal of Clinical Endocrinology and Metabolism 80 8 (1995): 2342-2346. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029093545&partnerID=MN8TOARS.
    10.1210/jcem.80.8.7629227
Resumo em conferência
  1. Rodrigues, Ricardo; Pires, Carolina; Carmo Martins; Valeriano Leite; Tiago Nunes da Silva; Branca Maria Cavaco. "TARGETING EGFR IN COMBINATION WITH LENVATINIB IN THYROID CANCER CELLS". Trabalho apresentado em 75ª Reunião Anual da SPEDM, 2024.
    Aceite para publicação
  2. Rodrigues, Ricardo; Tiago Nunes da Silva; Ana Saramago; Pires, Carolina; Miguel Rito; Saudade André; Raquel Dias; Valeriano Leite; Branca Maria Cavaco. "IS LIQUID BIOPSY A PROMISING TOOL FOR BRAF+ ANAPLASTIC THYROID CANCER MANAGEMENT? A CASE REPORT". Trabalho apresentado em Congresso Português de Endocrinologia ¿ 75ª Reunião Anual da SPEDM, 2024.
    Aceite para publicação
  3. Damásio, Inês; Pires, Carolina; Cavaco, Branca; Leite, Valeriano. "Ativação paradoxal via MAPK por sorafenib em doente com carcinoma familiar da tiroide e mutação HRAS". Vilamoura, 2023.
    Publicado
  4. da Silva, Tiago Nunes; Rodrigues, Ricardo; Rito, Miguel; Saramago, Ana; Pires, Carolina; Horta, Mariana; Leite, Valeriano; Cavaco, Branca. "A clinical and molecular study of a real-world cohort of braf v600e anaplastic thyroid carcinoma treated with dabrafenib and trametinib". Brussels, 2022.
    Publicado

Outros

Outra produção
  1. 65 Poster Presentations in Conferences from 1993 to 2024. 2024. Cavaco, B.M..
    10.1109/inss.2009.5409914
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/09 - Atual "Targeted therapy in aggressive thyroid cancer - unravelling novel resistance mechanisms, predictive biomarkers and therapeutic targets"
Orientador
 Doctoral Programme in Health Sciences – 4th Edition (Academic Year 2022/2023), NOVA Medical School (NMS) - Faculdade de Ciências Médicas da Universidade Nova de Lisboa (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09 - Atual Identification of novel genetic variants that increase risk and aggressiveness of paediatric thyroid cancer with impact in diagnosis and treatment
Orientador de Carolina Saraiva de Matos Pires
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/11 - 2022/12 "Biologia Molecular"
Orientador
 Supervisão de Estágio no âmbito de Internato Médico - Formação Específica em Endocrinologia - 4º ano de Internato Médico (Outra)
Hospital das Forças Armadas, Portugal
2020/09 - 2022/02/22 Study of molecular and cellular mechanisms involved in anaplastic thyroid carcinoma aggressiveness and response to therapy
Orientador de Ricardo Miguel dos Santos Rodrigues
Master in Molecular Biology and Genetics (Mestrado)
Faculdade de Ciências, da Universidade de Lisboa, Portugal
2016/03 - 2021/07 Molecular and clinical characterisation of aggressive thyroid cancers
Orientador de Joana Mafalda Marques Simões Pereira
PhD in Medicine (specialty of Clinical Medicine - Endocrinology, Metabolic and Nutrition Diseases) (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2019/12/03 Study of the role of CHEK2, MAP2K5, MYO1F and SPRY4 in familial thyroid cancer aetiology
Orientador de Carolina Saraiva de Matos Pires
 Master in Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018 - 2019/11/18 “Exploring Tumor-Macrophage Interaction in Anaplastic Thyroid Cancer”
Orientador de Rodrigo Manuel Ferreira Eduardo
 Master in Biochemistry for Health (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/03 - 2019/05 “Familial thyroid cancer – Identification of novel susceptibility genes”.
Orientador de Inês Filipa Jorge Reis Marques
 PhD Programme In Regenerative Medicine and Mechanisms of Disease - ProRegeM (Doutoramento)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/03/12 - 2018/03/29 Rotation Title: "Identification of novel susceptibility genes in familial nonmedullary thyroid cancer"
Orientador de Rakhi Chanda Roy
 Master in Biomedical Research (Outra)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2016/12/15 “Estudo do efeito do Palbociclib e do Tipifarnib em linhas celulares de carcinomas anaplásicos da tiróide”
Orientador de Sara Patrícia Lopes Ventura
 Master in Biomedical Sciences (Mestrado)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2015 - 2016/09/22 “Molecular characterization of new candidate genes for familial thyroid cancer"
Orientador de Inês Fernandes Gomes
 Master in Celullar and Molecular Biology (MBCM) (Mestrado)
Universidade de Coimbra, Portugal
2014 - 2015/12/10 “Identification of novel familial thyroid cancer susceptibility genes – functional characterization of the C8orf48 gene”
Orientador de Tiago Manuel Costa Pinheiro
 Master in Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2014/12/17 “Study of novel compounds for the treatment of anaplastic thyroid carcinomas”
Orientador de Ana Teresa de Sousa e Menezes Matias
 Master in Evolutive Biology and Development (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014/05/12 - 2014/06/06 Rotation Title: “Identification of susceptibility genes associated to familial nonmedullary thyroid carcinoma: functional characterization of novel germline variants”.
Orientador de Ilda Patrícia Tavares da Silva Ribeiro
Inter-University Doctoral Programme in Ageing and Chronic Disease – PhDOC (Outra)
2012 - 2013/12/11 “Study of the DICER1 and C8orf48 genes in familial forms of multinodular goiter and thyroid cancer”
Orientador de Cristiana Catarina Dias Santos
 Master in Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013/07 - 2013/07 “Molecular characterization of the poorly differentiated and undifferentiated thyroid carcinomas using genome-wide approaches”
Coorientador de Jaime Miguel Gomes Pita
 PhD in Biochemistry – Molecular Genetics (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013/02/11 - 2013/03/08 Rotation Title: “Role of histone methyltransferase EZH2 mutations in the development of aggressive thyroid carcinomas”
Orientador de Tatiana Sofia Lopes Lourenço
 Inter-University Doctoral Programme in Ageing and Chronic Disease – PhDOC (Outra)
2011 - 2012/12 “Identification of molecular alterations involved in the progression and desdiferentiation of thyroid carcinomas”.
Orientador de Inês Filipa Terraço de Figueiredo
 Master in Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011 - 2012/12 “Study of the FOXE1 gene and identification of novel susceptibility genes involved in familial thyroid cancer”.
Orientador de Joana Filipa de Sousa Pereira
 Master in Molecular Genetics and Biomedicine (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2010 - 2011 “Molecular and functional characterisation of genetic variants of thyroid transcription factors in familial thyroid cancer”
Orientador de Joana Gomes da Silva
 Master in Human Biology and Environment (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2008 “Molecular diagnosis of familial hypercalcemia”.
Orientador de Nádia Raquel Henriques Rei
 Master in Molecular Biology and Genetics (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2007 "Epigenetic defects in the GNAS locus in pseudohypoparathyroidism 1b"
Orientador de Rute Tomaz
 Graduation in Biochemistry (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal
1996 - 2007 Collaboration in teaching experimental methodology to 12 students for Graduation Thesis in Biochemistry or Biology (1996-2007).
Coorientador
 Graduation Thesis in Biochemistry or Biology (Licenciatura/Bacharelato)
2006 - 2006 "Mapping and identification of genes involved in familial non-medullary thyroid carcinomas"
Orientador de Pedro Batista
 Graduation in Biochemistry (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal