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João Laranjinha is professor of Biochemistry and Molecular Biology at the Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. He graduated in Pharmaceutical Sciences (University of Coimbra) in 1984 and got a PhD in Biochemistry (University of Coimbra) in 1996. He did Postdoc studies with Enrique Cadenas in 1997-1998 at the Dept. Molecular Pharmacology and Toxicology, University Southern California, Los Angeles, USA. His research is focused on the functional impact of nitric oxide in the brain as a neurometabolic regulator and as a mediator of neurovascular coupling with impact in aging and neurodegeneration. He is also interested in dietary nitrite-driven regulatory processes, encompassing the non-enzymatic production of nitric oxide along the nitrate:nitrite:NO pathway. He has been awarded several prizes, including the Science and Humanity award by The Oxygen Club of California and is member of the editorial board of major journals in his area of research, including Redox Biology, Free Radical Biology and Medicine, Archives of Biochemistry and Biophysics, Free Radical Research and Biofactors. He has chaired the organizing and scientific committees of several international conferences, including the European (SFRRE 2007) and International (SFRRI 2018) meetings of the Society for Free Radical Research. He has been member of the council of the European Society for Neurochemistry and the European Society for Free Radical Research for several years and President of the Portuguese Biochemical Society (2014-18). Currently, he serves as member of the Advanced Courses Committee of FEBS and as the president of the General Assembly of the Portuguese Biochemical Society.
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Identificação

Identificação pessoal

Nome completo
João António Nave Laranjinha

Identificadores de autor

Ciência ID
3014-5272-6F5D
ORCID iD
0000-0003-4370-5177

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
Formação
Grau Classificação
2006
Concluído
 Habilitation in Biochemistry and tenure (Título de Agregado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Radicais livres em processos biológicos, bioquímica e fisiopatologia" (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade
1996
Concluído
 Biochemistry (Doutoramento)
Especialização em Biochemistry
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Pressão oxidativa em lipoproteínas humanas de baixa densidade (LDL): mecanismos de antioxidação por ácidos fenólicos da dieta. Oxidative stress in human low density lipoproteins: antioxidant mechanism" (TESE/DISSERTAÇÃO)
 Distinção e louvor por unanimidade
1996
Concluído
 Farmácia (Doutoramento)
Especialização em Especialidade: Bioquímica
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Pressão Oxidativa em Lipoproteínas Humanas de Baixa Densidade (ldl): Mecanismos de Antioxidação por Ácidos Fenólicos da Dieta" (TESE/DISSERTAÇÃO)
1987
Concluído
 Ciências Farmacêuticas (Curso de mestrado (conclusão do curso de especialização))
Especialização em Proof of Pedagogic Aptitude and Scientific Capacity (academic degree equivalent to Master degree in Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
 14
1984
Concluído
 Ciências Farmacêuticas (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
 14
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1999 - Atual Investigador principal (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2013 - Atual Professor Catedrático (Docente Universitário) Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016 - 2019 Professor Catedrático (Docente Universitário) Universidade de Coimbra, Portugal
2013 - 2016 Professor Catedrático (Docente Universitário) Universidade de Coimbra Faculdade de Farmácia, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2018 - 2019 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Coimbra, Portugal
2016 - 2019 Conselho científico/técnico-científico ou orgão correspondente Universidade de Coimbra, Portugal
2016 - 2019 Conselho geral ou orgão correspondente Universidade de Coimbra, Portugal
2013 - 2016 Conselho científico/técnico-científico ou orgão correspondente Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2016 Conselho geral ou orgão correspondente Universidade de Coimbra Faculdade de Farmácia, Portugal
2013 - 2016 Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Coimbra Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2002/03/01 - 2005/10/30 Real-time measurement of nitric oxide in hippocampal brain slices: modulation by tissue redox state with implications for neuronal degeneration
?
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Concluído

Projeto

Designação Financiadores
2023/03/01 - 2026/02/28 The Neurovascular Coupling as a biomarker and a target for cognitive enhancement in aging and vascular dementia through an innovative dietary nitrate-driven nitric oxide redox cycle: a translational study
2022.05454.PTDC
PI
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Em curso
2018/07/26 - 2021/07/25 Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism-based approach driven by nitrite and ascorbic acid from diet
PTDC/MED-NEU/29099/2017
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/25 - 2021/07/24 Monitorização in vivo de marcadores neurometabólicos com biossensores baseados em microelétrodos
PTDC/BTM-SAL/28261/2017
Universidade de Coimbra, Portugal

Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2014/03/01 - 2015/09/30 Ageing@Coimbra: Um Centro de Co-localização na Rede Europeia de Conhecimento e Inovação para o Envelhecimento Saudável e Ativo
EIT-KIC/IVE/0043/2013
Universidade de Coimbra, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal

Administração Regional de Saúde do Centro IP, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/07/03 - 2015/09/30 Nitric oxide is a master regulator of brain energetic metabolism: resolving aerobic glycolysis
PTDC/BBB-BQB/3217/2012
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2014/12/31 Nitrate:Nitrite:Nitric oxide as a key pathway in gastrointestinal and cardiovascular physiology: uncovering new health properties of red wine and olive oil
PTDC/AGR-ALI/115744/2009
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/05/01 - 2013/10/31 Design de sensores químicos e biossensores compósitos para a monitorização em tempo-real e em simultâneo de óxido nítrico e oxigénio in vivo no cérebro.
PTDC/SAU-BEB/103228/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/05/01 - 2013/10/31 Neurovascular coupling between neuronal activity and blood flow in brain mediated by nitric oxide. Implications in Alzheimer disease
PTDC/SAU-NEU/108992/2008
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/02/05 - 2013/07/31 Análise dos mecanismos moleculares que determinam disfunção da alfa-sinucleína e a citoxicidade na doença de Parkinson - o papel do GDNF
PTDC/SAU-NEU/101928/2008
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/06/01 - 2013/06/30 In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
PTDC/SAU-NEU/103538/2008
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/04/01 - 2012/03/31 Desenvolvimento de uma micro-sonda para fluxometria laser Doppler capilar em cérebro de ratos
PTDC/SAU-NEU/101726/2008
Universidade de Coimbra Departamento de Física, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/05/15 - 2010/05/14 New biological functions for wine polyphenols: cellular and anti-inflammatory actions via nitric oxide production from nitrite
PTDC/AGR-ALI/71262/2006
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2005/05/02 - 2008/06/30 ACÇÃO PROTECTORA DE POLIFENÓIS DO VINHO TINTO NA INFLAMAÇÃO E DISFUNÇÃO DO ENDOTÉLIO VASCULAR: IMPLICAÇÕES NA PREVENÇÃO DA ATEROSCLEROSE
POCI/AGR/59919/2004
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
1998/10 - 2001/10 Photooxidation of Human Low Density Lipoproteins (LDL) by Sensitizers Used in Photodynamic Therapy. Inhibition by Phenolic Antioxidants and Effects on Cells
NA
Investigador responsável
Fundação para a Ciência e a Tecnologia
1999/03 - 2001/03 Nitric Oxide and Dopamine-mediated damage to mitochondria in neuronal degeneration.
NA
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Gonçalves, João S.; Marçal, Ana L.; Marques, Bárbara S.; Costa, Filipa D.; Laranjinha, João; Rocha, Bárbara S.; Lourenço, Cátia F.. "Dietary nitrate supplementation and cognitive health: the nitric oxide-dependent neurovascular coupling hypothesis". Biochemical Society Transactions (2024): http://dx.doi.org/10.1042/bst20230491.
    10.1042/bst20230491
  2. Reis, Ana; Rocha, Barbara S.; Laranjinha, João; de Freitas, Victor. "Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on nitric oxide bioavailability in hypertension". FEBS Letters (2024): http://dx.doi.org/10.1002/1873-3468.14812.
    10.1002/1873-3468.14812
  3. Nunes, Carla; Laranjinha, João. "Nitric Oxide Production from Nitrite plus Ascorbate during Ischemia upon Hippocampal Glutamate NMDA Receptor Stimulation". BioChem 3 2 (2023): 78-90. http://dx.doi.org/10.3390/biochem3020006.
    10.3390/biochem3020006
  4. Dias, Cândida; Fernandes, Eliana; Barbosa, Rui M.; Laranjinha, João; Ledo, Ana. "Astrocytic aerobic glycolysis provides lactate to support neuronal oxidative metabolism in the hippocampus". BioFactors 49 4 (2023): 875-886. http://dx.doi.org/10.1002/biof.1951.
    10.1002/biof.1951
  5. Reva, Katerina; Laranjinha, João; Rocha, Bárbara S.. "Epigenetic Modifications Induced by the Gut Microbiota May Result from What We Eat: Should We Talk about Precision Diet in Health and Disease?". Metabolites 13 3 (2023): 375. http://dx.doi.org/10.3390/metabo13030375.
    10.3390/metabo13030375
  6. Fraga, César G.; Trostchansky, Andrés; Rocha, Barbara S.; Laranjinha, João; Rubbo, Homero; Galleano, Monica. "(Poly)phenols and nitrolipids: Relevant participants in nitric oxide metabolism". Molecular Aspects of Medicine 89 (2023): 101158. http://dx.doi.org/10.1016/j.mam.2022.101158.
    10.1016/j.mam.2022.101158
  7. Dias, C.; Lourenço, C.F.; Laranjinha, J.; Ledo, A.. "Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite". Free Radical Biology and Medicine 193 (2022): 779-786. http://dx.doi.org/10.1016/j.freeradbiomed.2022.11.021.
    10.1016/j.freeradbiomed.2022.11.021
  8. Gonçalves, João S.; Seiça, Raquel M.; Laranjinha, João; Lourenço, Cátia F.. "Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats". Free Radical Biology and Medicine 193 (2022): 669-675. http://dx.doi.org/10.1016/j.freeradbiomed.2022.11.009.
    10.1016/j.freeradbiomed.2022.11.009
  9. Ledo, A.; Fernandes, E.; Salvador, A.; Laranjinha, J.; Barbosa, R.M.. "In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity". Redox Biology 50 (2022): 102250. http://dx.doi.org/10.1016/j.redox.2022.102250.
    10.1016/j.redox.2022.102250
  10. Lourenço, Cátia F.; Laranjinha, João. "Nitric Oxide Pathways in Neurovascular Coupling Under Normal and Stress Conditions in the Brain: Strategies to Rescue Aberrant Coupling and Improve Cerebral Blood Flow". Frontiers in Physiology 12 (2021): http://dx.doi.org/10.3389/fphys.2021.729201.
    10.3389/fphys.2021.729201
  11. João Laranjinha; Carla Nunes; Ana Ledo; Cátia Lourenço; Bárbara Rocha; Rui M. Barbosa. "The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling". Neurochemical Research (2021): https://doi.org/10.1007/s11064-020-03015-0.
    10.1007/s11064-020-03015-0
  12. Laranjinha, João; Ledo, Ana; Lourenço, Cátia; Cadenas, Enrique; Barbosa, Rui. "The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: switching signaling to degeneration". Free Radical Biology & Medicine 162 (2021): 500-513.
    Publicado
  13. Nunes, C; Laranjinha, J. "Nitric oxide and dopamine metabolism converge via mitochondrial dysfunction in the mechanisms of neurodegeneration in Parkinson’s disease.". Archives of Biochemistry and Biophysics 704 (2021): 108877.
    Aceite para publicação
  14. Mancini, G; Dias, C; Lourenço, C; Laranjinha, J; de Bem, A; Ledo, A. Autor correspondente: Ledo, A. "A high fat/cholesterol diet recapitulates some Alzheimer's disease-like features in mice: focus on hippocampal mitochondrial dysfunction". Journal of Alzheimer's Disease 82 (2021): 1619-1633.
    Publicado
  15. Matilde S. Rodrigues; Cláudia Ferreira; Cândida Dias; Anna Pliássova; Lisiane Souza; Ana Ledo; João Laranjinha; Rodrigo A. Cunha; Attila Köfalvi. "An optimized spectrophotometric assay reveals increased activity of enzymes involved in 2-arachidonoyl glycerol turnover in the cerebral cortex of a rat model of Alzheimer’s disease". European Journal of Neuroscience (2020): https://doi.org/10.1111/ejn.14944.
    10.1111/ejn.14944
  16. Rocha, Bárbara S.; Laranjinha, João. "Nitrate from diet might fuel gut microbiota metabolism: Minding the gap between redox signaling and inter-kingdom communication". Free Radical Biology and Medicine 149 (2020): 37-43. http://dx.doi.org/10.1016/j.freeradbiomed.2020.02.001.
    10.1016/j.freeradbiomed.2020.02.001
  17. Nunes, Carla; Figueiredo, Rui; Laranjinha, João; da Silva, Gabriela Jorge. "Intestinal cytotoxicity induced by Escherichia coli is fully prevented by red wine polyphenol extract: Mechanistic insights in epithelial cells". Chemico-Biological Interactions 310 (2019): 108711. http://dx.doi.org/10.1016/j.cbi.2019.06.024.
    10.1016/j.cbi.2019.06.024
  18. Rocha, Bárbara S.; Correia, Mariana G.; Pereira, Anabela; Henriques, Isabel; Da Silva, Gabriela J.; Laranjinha, João. "Inorganic nitrate prevents the loss of tight junction proteins and modulates inflammatory events induced by broad-spectrum antibiotics: A role for intestinal microbiota?". Nitric Oxide 88 (2019): 27-34. http://dx.doi.org/10.1016/j.niox.2019.04.001.
    10.1016/j.niox.2019.04.001
  19. Carla Nunes; Víctor Freitas; Leonor Almeida; João Laranjinha. "Red wine extract preserves tight junctions in intestinal epithelial cells under inflammatory conditions: implications for intestinal inflammation". Food & Function (2019): https://doi.org/10.1039/C8FO02469C.
    10.1039/C8FO02469C
  20. Ledo, Ana; Lourenço, Cátia F.; Laranjinha, João; Gerhardt, Greg A.; Barbosa, Rui M.. "Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry". Current Opinion in Electrochemistry 12 (2018): 129-140. http://dx.doi.org/10.1016/j.coelec.2018.05.018.
    10.1016/j.coelec.2018.05.018
  21. Ferreira, Nuno R.; Ledo, Ana; Laranjinha, João; Gerhardt, Greg A.; Barbosa, Rui M.. "Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays". Bioelectrochemistry 121 (2018): 142-150. http://dx.doi.org/10.1016/j.bioelechem.2018.01.009.
    10.1016/j.bioelechem.2018.01.009
  22. Laranjinha, João. "Age-dependent impairment of neurovascular and neurometabolic coupling in the hippocampus". Frontiers in Physiology 9 (2018): 913.
    Publicado
  23. Laranjinha, João. "Modulation of cellular respiration by endogenously produced nitric oxide in rat hippocampal slices". Methods Mol BIol 1782 (2018): 89-107.
    Publicado
  24. Laranjinha, João. "Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices". Analytical Biochemistry 551 (2018): 43-50.
    Publicado
  25. Nunes, C.; Almeida, L.; Barbosa, R.M.; Laranjinha, J.. "Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation". Food and Function 8 1 (2017): 387-396. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010953233&partnerID=MN8TOARS.
    10.1039/c6fo01529h
  26. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration". Free Radical Biology and Medicine 108 (2017): 668-682. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018262522&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2017.04.026
  27. Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling". Experimental Neurology 291 (2017): 36-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011654048&partnerID=MN8TOARS.
    10.1016/j.expneurol.2017.01.013
  28. Laranjinha, João. "Combined in vivo amperometric oximetry and electrophysiology in a single sensor – a tool for epilepsy research". Analytical Chemistry 89 (2017): 12383-12390.
    Publicado
  29. Laranjinha, João. "Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays". Scientific Reports 7 (2017): 1-12.
    Publicado
  30. Laranjinha, João. "European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).". Redox Biology 13 (2017): 94-162.
    Publicado
  31. Laranjinha, João. "Ceramic-based Multi-Site Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue". Analytical Chemistry 89 (2017): 1674-1683.
    Publicado
  32. Rocha, B.S.; Correia, M.G.; Fernandes, R.C.; Gonçalves, J.S.; Laranjinha, J.. "Dietary nitrite induces occludin nitration in the stomach". Free Radical Research 50 11 (2016): 1257-1264. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991039527&partnerID=MN8TOARS.
    10.1080/10715762.2016.1234049
  33. Rocha, B.S.; Lundberg, J.O.; Radi, R.; Laranjinha, J.. "Role of nitrite, urate and pepsin in the gastroprotective effects of saliva". Redox Biology 8 (2016): 407-414. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979517818&partnerID=MN8TOARS.
    10.1016/j.redox.2016.04.002
  34. Lourenço, C.F.; Ledo, A.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M.. "Microelectrode array biosensor for high-resolution measurements of extracellular glucose in the brain". Sensors and Actuators, B: Chemical 237 (2016): 298-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976594136&partnerID=MN8TOARS.
    10.1016/j.snb.2016.06.083
  35. Rocha, B.S.; Nunes, C.; Laranjinha, J.. "Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome". International Journal of Biochemistry and Cell Biology 81 (2016): 393-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-85001032995&partnerID=MN8TOARS.
    10.1016/j.biocel.2016.10.021
  36. Dias, C.; Lourenço, C.F.; Ferreiro, E.; Barbosa, R.M.; Laranjinha, J.; Ledo, A.. "Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation". Neurobiology of Aging 46 (2016): 84-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978903965&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2016.06.012
  37. Santos, R.M.; Rodrigues, M.S.; Laranjinha, J.; Barbosa, R.M.. "Corrigendum to 'Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain' [Biosens. Bioelectron. 44 (2013) 152-159]. doi: 10.1016/j.bios.2013.01.015.". Biosensors and Bioelectronics 79 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84956735557&partnerID=MN8TOARS.
    10.1016/j.bios.2015.10.086
  38. Laranjinha, João. "Red wine polyphenol extract protect intestinal epithelial cells from inflammation via complementary modulation of JAK/STAT and Nrf2 pathways". Toxicology Research 5 (2016): 53-65.
    Publicado
  39. Cassilda Pereira; Rui M. Barbosa; João Laranjinha. "Dietary nitrite induces nitrosation of the gastric mucosa: the protective action of the mucus and the modulatory effect of red wine". The Journal of Nutritional Biochemistry 26 5 (2015): 476-483. https://doi.org/10.1016%2Fj.jnutbio.2014.12.004.
    10.1016/j.jnutbio.2014.12.004
  40. Lourenço, C.F.; Ledo, A.; Dias, C.; Barbosa, R.M.; Laranjinha, J.. "Neurovascular and neurometabolic derailment in aging and alzheimer's disease". Frontiers in Aging Neuroscience 7 MAY (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84931266835&partnerID=MN8TOARS.
    10.3389/fnagi.2015.00103
  41. Rocha, B.S.; Gago, B.; Barbosa, R.M.; Cavaleiro, C.; Laranjinha, J.. "Ethyl nitrite is produced in the human stomach from dietary nitrate and ethanol, releasing nitric oxide at physiological pH: Potential impact on gastric motility". Free Radical Biology and Medicine 82 (2015): 160-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925061584&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2015.01.021
  42. Nunes, C.; Teixeira, N.; Serra, D.; Freitas, V.; Almeida, L.; Laranjinha, J.. "Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways". Toxicology Research 5 1 (2015): 53-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951861397&partnerID=MN8TOARS.
    10.1039/c5tx00214a
  43. Santos, R.M.; Laranjinha, J.; Barbosa, R.M.; Sirota, A.. "Simultaneous measurement of cholinergic tone and neuronal network dynamics in vivo in the rat brain using a novel choline oxidase based electrochemical biosensor". Biosensors and Bioelectronics 69 (2015): 83-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923082333&partnerID=MN8TOARS.
    10.1016/j.bios.2015.02.003
  44. Ferreira, N.R.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J.. "Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: A novel functional interplay". Brain Research Bulletin 114 (2015): 13-19. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925442099&partnerID=MN8TOARS.
    10.1016/j.brainresbull.2015.03.002
  45. Santos, R.M.; Lourenço, C.F.; Gerhardt, G.A.; Cadenas, E.; Laranjinha, J.; Barbosa, R.M.. "Erratum: Evidence for a pathway that facilitates nitric oxide diffusion in the brain (Neurochem. Int. (2011) 59 (90-96) DOI: 10.1016/j.neuint.2011.05.016)". Neurochemistry International 91 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84951179683&partnerID=MN8TOARS.
    10.1016/j.neuint.2015.11.004
  46. Laranjinha, João. "Age-associated changes of nitric oxide concentration dynamics in the central nervous system of Fisher 344 rats.". Cell Mol Neurobiol 35 (2015): 33-44.
    Publicado
  47. Rocha, B.S.; Nunes, C.; Pereira, C.; Barbosa, R.M.; Laranjinha, J.. "A shortcut to wide-ranging biological actions of dietary polyphenols: Modulation of the nitrate-nitrite-nitric oxide pathway in the gut". Food and Function 5 8 (2014): 1646-1652. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904984090&partnerID=MN8TOARS.
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  51. Ledo, A.; Lourenço, C.F.; Caetano, M.; Barbosa, R.M.; Laranjinha, J.. "Age-Associated Changes of Nitric Oxide Concentration Dynamics in the Central Nervous System of Fisher 344 Rats". Cellular and Molecular Neurobiology 35 1 (2014): 33-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921938863&partnerID=MN8TOARS.
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  52. Oliveira, S.C.B.; Santarino, I.B.; Enache, T.A.; Nunes, C.; Laranjinha, J.; Barbosa, R.M.; Oliveira-Brett, A.M.. "Human colon adenocarcinoma HT-29 cell: Electrochemistry and nicotine stimulation". Bioelectrochemistry 94 (2013): 30-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879324150&partnerID=MN8TOARS.
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  55. Santos, R.M.; Rodrigues, M.S.; Laranjinha, J.; Barbosa, R.M.; Santos, Ricardo M.; Rodrigues, Marcelo S.; Laranjinha, João; Barbosa, Rui M.. "Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain". Biosensors and Bioelectronics 44 1 (2013): 152-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873721422&partnerID=MN8TOARS.
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  56. Rocha, B.S.; Gago, B.; Barbosa, R.M.; Lundberg, J.O.; Mann, G.E.; Radi, R.; Laranjinha, J.. "Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: A novel interaction between dietary nitrate and gut proteins". Free Radical Biology and Medicine 58 (2013): 26-34. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875974388&partnerID=MN8TOARS.
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  58. Figueiras, E.; Oliveira, R.; Lourenço, C.F.; Campos, R.; Humeau-Heurtier, A.; Barbosa, R.M.; Laranjinha, J.; et al. "Self-mixing microprobe for monitoring microvascular perfusion in rat brain". Medical and Biological Engineering and Computing 51 1-2 (2013): 103-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874633368&partnerID=MN8TOARS.
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    10.1016/S0006-2952(97)00470-X
  108. Vieira, Otília V.; Laranjinha, João A.; Madeira, Vítor M.; Almeida, Leonor M.; Vieira, O.V.; Laranjinha, J.A.N.; Madeira, V.M.C.; Almeida, L.M.. "Rapid isolation of low density lipoproteins in a concentrated fraction free from water-soluble plasma antioxidants". Journal of Lipid Research 37 12 (1996): 2715-2721. http://hdl.handle.net/10316/12736.
  109. Laranjinha, J.; Vieira, O.; Almeida, L.; Madeira, V.. "Inhibition of metmyoglobin/H2O2-dependent low density lipoprotein lipid peroxidation by naturally occurring phenolic acids". Biochemical Pharmacology 51 4 (1996): 395-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029664717&partnerID=MN8TOARS.
    10.1016/0006-2952(95)02171-X
  110. Laranjinha, J.; Vieira, O.; Madeira, V.; Almeida, L.. "Two related phenolic antioxidants with opposite effects on vitamin E content in low density lipoproteins oxidized by ferrylmyoglobin: Consumption vs regeneration". Archives of Biochemistry and Biophysics 323 2 (1995): 373-381. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028840619&partnerID=MN8TOARS.
    10.1006/abbi.1995.0057
  111. Laranjinha, J.; Almeida, L.; Madeira, V.. "Reduction of ferrylmyoglobin by dietary phenolic acid derivatives of cinnamic acid". Free Radical Biology and Medicine 19 3 (1995): 329-337. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029160111&partnerID=MN8TOARS.
    10.1016/0891-5849(95)00039-Z
  112. Laranjinha, J.A.N.; Almeida, L.M.; Madeira, V.M.C.. "Reactivity of dietary phenolic acids with peroxyl radicals: Antioxidant activity upon low density lipoprotein peroxidation". Biochemical Pharmacology 48 3 (1994): 487-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027982195&partnerID=MN8TOARS.
    10.1016/0006-2952(94)90278-X
  113. Laranjinha, J.A.N.; Almeida, L.M.; Madeira, V.M.C.. "Lipid peroxidation and its inhibition in low density lipoproteins: Quenching of cis-parinaric acid fluorescence". Archives of Biochemistry and Biophysics 297 1 (1992): 147-154. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026782042&partnerID=MN8TOARS.
    10.1016/0003-9861(92)90653-E
Capítulo de livro
  1. Ledo, A.; Rocha, B. S.; Laranjinha, J.. "Bioactive Lipids and the Gut-Brain Axis: Diet as a Modulator of Bioactivity and Diversity of Lipids in the Brain". In Advances in Experimental Medicine and Biology, 147-168. Springer International Publishing, 2019.
    10.1007/978-3-030-11488-6_10
  2. Lourenço, Cátia F.; Ledo, Ana; Barbosa, Rui M.; Laranjinha, João. "Neurovascular Coupling Mediated by Neuronal Derived-Nitric Oxide: Mechanisms in Health and Dysfunction with Impact on Aging and Alzheimer’s Disease". In Biochemistry of Oxidative Stress, 289-308. Springer International Publishing, 2016.
    10.1007/978-3-319-45865-6_19
  3. Laranjinha, João. "The modulation of glutamate NMDA receptor activity by etanol and polyphenols". In A Toxicological and Pharmacological Approach to Chemico-Biological Interactions at a Membrane Level. Transworld Research Network, 2012.
    Publicado
  4. Laranjinha, J.. "Translation of Chemical Properties of Polyphenols into Biological Activity with Impact on Human Health". In Recent Advances in Polyphenol Research, 269-282. Wiley-Blackwell & Sons, Ltd, UK, 2010.
    10.1002/9781444323375.ch11
  5. Laranjinha, João. "Translation of Chemical Properties of Polyphenols into Biological Activity with Impact on Human Health". In Recent Advances in Polyphenol Research, 269-282. Wiley-Blackwell, 2010.
    10.1002/9781444323375.ch11
  6. Laranjinha, João. "Oxidative Stress: from the 80’s to recent update". In Oxidative Stress, Inflammation and Angiogenesis in the Metabolic Syndrome. Estados Unidos: Springer Netherlands, 2009.
    Publicado
  7. Laranjinha, João. "Nitric oxide in neurodegenerative pathways". In Free Radical Pathophysiology. Kerala, Índia: Transworld Research Network, 2008.
    Publicado
  8. Laranjinha, João. "Caffeic acid-driven formation of nitric oxide from nitrite". In Polyphenols Communications, 261-262. Helsinki, Finlândia, 2004.
    Publicado
  9. Laranjinha, João. "Caffeic acid and related compounds: biochemical and cellular effects". In Handbook of Antioxidants, 279-302. New York, Estados Unidos: Marcel Dekker Inc, 2001.
    Publicado
Livro
  1. Laranjinha, J.. Oxidative stress: From the 1980's to recent update. 2009.
    10.1007/978-1-4020-9701-0_2
Tese / Dissertação
  1. Ferreira, Luciana Carolina Lopes. "Pathophysiology of Doxorubicin Cardiotoxicity: From Mitochondrial Homeostasis to Biological Clocks". Doutoramento, 2019. http://hdl.handle.net/10316/87585.
  2. Ribeiro, Ricardo Manuel Esteves. "Innovative pathways underlying the etiology and the therapeutics via modulation of the gut microbiota". Mestrado, 2018. http://hdl.handle.net/10316/84748.
  3. Arrais, Débora Gomes. "Relatórios de Estágio e Monografia intitulada “Novas Estratégias Biomédicas: Modulação do Epigenoma e Terapia do Cancro"". Mestrado, 2018. http://hdl.handle.net/10316/84634.
  4. Renato Mateus Domingos. "Conserved structural and dynamic aspects behind Ohr enzymatic catalysis: Ohr as potential drug targets". Doutoramento, 2018. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-07032019-090053/.
  5. Queiroz, João Pedro Nunes. "O microbiota e o ser humano". Mestrado, 2017. http://hdl.handle.net/10316/83633.
  6. Brazão, João António Lima de Andrade Conde. "Relatório de estágio e monografia intitulada :"mecanismos epigenéticos na formação de memória e capacidades cognitivas"". Mestrado, 2017. http://hdl.handle.net/10316/83661.
  7. Silva, Miguel Pereira da. "Relatórios de Estágio e Monografia intitulada “O Parkinson, a Microbiota Intestinal e a Epigenética”". Mestrado, 2017. http://hdl.handle.net/10316/83691.
  8. Rocha, Barbara Silva. "Microbiota-host interactions during antibiotic therapy: unveiling novel redox signaling pathways with impact on gut homeostasis". Mestrado, 2017. http://hdl.handle.net/10316/82428.
  9. Ferreira, Nuno Ricardo Esteves. "The interplay of ascorbic acid, nitric oxide and nitrite in the brain and its role on the regulation of cerebral blood flow: an in vivo electrochemical study". Doutoramento, 2016. http://hdl.handle.net/10316/29588.
  10. Pereira, Cassilda Maria Lopes. "The role of nitrite-derived nitric oxide in gastric physiology: biochemical mechanisms, molecular targets and the modulatory effect of red wine". Doutoramento, 2016. http://hdl.handle.net/10316/29576.
  11. Tuca, Octavian. "Doença de Alzheimer e resistência à insulina". Mestrado, 2015. http://hdl.handle.net/10316/88778.
  12. Henriques, Tiago André Ferreira. "High-Resolution Respirometry for Metabolic Profiling of Acute Rat Hippocampal Slices". Mestrado, 2013. http://hdl.handle.net/10316/24702.
  13. Rocha, Bárbara Silva. "Biological role of nitrite and nitric oxide in the stomach: from diet to protein tyrosine with implications for gastric physiology". Doutoramento, 2012. http://hdl.handle.net/10316/21553.
  14. Fonseca, Ana rita de Jesus Alves da. "Nitric oxide mediates neurovascular coupling in the brain effect of polyphenols in animal models of Alzheimer's disease". Mestrado, 2012. http://hdl.handle.net/10316/24966.
  15. Ferreira, Elisabete Priscila Pinto. "The role of polyphenols and reactive nitrogen species in inflammatory conditions of the gastrointestinal tract|". Mestrado, 2011. http://hdl.handle.net/10316/25851.
  16. Frade, João Gonçalo Leal de Oliveira e Silva. "Real-time change of nitric oxide in rat hippocampal slices and astrocytic glutathione release via glutamate-dependent pathways". Doutoramento, 2008. http://hdl.handle.net/10316/7449.
  17. Ledo, Ana Margarida da Cruz. "Dinâmica de concentração do óxido nítrico produzido no hipocampo de rato por activação de receptores do glutamato". Doutoramento, 2007. http://hdl.handle.net/10316/9660.
  18. Ferreira, Nuno Ricardo Esteves. "Detecção electroquímica de óxido nítrico em fatias de hipocampo de rato com micoeléctrodos de fibra de carbono". Mestrado, 2006. http://hdl.handle.net/10316/15830.
  19. Vieira, Maria Otília Vitoriana. "Citotoxicidade e sinalização em células endoteliais vasculares induzidas por lipoproteínas humanas (LDL) oxidadas: mecanismos de protecção por ácidos fenólicos da dieta". Doutoramento, 2000. http://hdl.handle.net/10316/515.
  20. Laranjinha, João António Nave. "Pressão oxidativa em lipoproteínas humanas de baixa densidade (LDL): Mecanismos de antioxidação por ácidos fenólicos da dieta". Doutoramento, 1996. http://hdl.handle.net/10316/512.

Outros

Outra produção
  1. Síndrome metabólico e dieta vegetariana: relação benéfica, deletéria ou irrelevante?. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. O síndrome metabólico agrupa um conjunto de fatores de risco associados a doenças cardíacas, vasculares, obesidade e diabetes, entre outras, estando, portanto, subjacente a problemas de saúde que afetam um número consideráv. 2016. Laranjinha, João António Nave. http://hdl.handle.net/10316/79505.
  2. Nutrigenómica e qualidade de vida : funções e eficácia de moduladores de NRF2 presentes em suplementos da dieta. Monografia realizada no âmbito da unidade Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. A alimentação, como é científica e empiricamente sabido, constitui um pilar da saúde. Na sociedade, ao longo das épocas, também em função de culturas diversas, os hábitos alimentares vão mudando, contribuindo para a saúde ou p. 2016. Laranjinha, João. http://hdl.handle.net/10316/42176.
  3. The pathogenesis of Parkinson Disease : the microbiota-gut-brain axis. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. A doença de Parkinson (PD) é a segunda perturbação neurodegenerativa mais prevalente na população acima de 65 anos. Caracteriza-se, essencialmente, pela perda de neurónios dopaminérgicos na substantia nigra pars compacta, l. 2016. Laranjinha, João António Nave. http://hdl.handle.net/10316/42906.
  4. The long and winding road of STAT3 in the mitochondria. Monografia realizada no âmbito da unidade Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. O STAT3, um fator de transcrição responsável pela ativação de vários oncogenes, tem sido estudado extensivamente dado o interesse biomédico da modulação da sua atividade. No entanto, esta proteína também exerce as suas ações,. 2016. Laranjinha, João António Nave. http://hdl.handle.net/10316/40861.
  5. The human microbiome: a fine line between symbiosis and pathogenesis. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. The evolution of human beings and the organisms that constitute their microflora is closely related, and their symbiotic relationship is essential for the development of both. The signalling pathways supporting the interact. 2016. Laranjinha, João António Nave. http://hdl.handle.net/10316/48473.
  6. Ação de flavonoides na doença inflamatória intestinal. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. A Doença Inflamatória Intestinal (DII), que inclui a Doença de Crohn (DC) e Colite Ulcerosa (CU), representa um grupo de doença inflamatória crónica do trato gastrointestinal. A etiologia exata da DII continua desconhecida,. 2015. Laranjinha, João. http://hdl.handle.net/10316/80765.
  7. Diabetes tipo 3: uma nova perspectiva sobre a doença de Alzheimer. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. A neurodegeneração que ocorre na doença de Alzheimer (DA) é consistentemente associada com um número de anormalidades características como morte celular, tranças neurofibrilares abundantes, depósitos de amilóide-ß, activaçã. 2014. Laranjinha, João António Nave. http://hdl.handle.net/10316/79910.
  8. Alzheimer: diabetes tipo 3?. Monografia realizada no âmbito da unidade de Estágio Curricular do Mestrado Integrado em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra. Na Europa são já mais de 7.3 milhões que sofrem de demência e prevê-se que estes números dupliquem nas próximas 3 Décadas. A Doença de Alzheimer (DA) é a forma mais comum de demência. Inúmeros estudos são feitos sobre esta. 2014. Laranjinha, João. http://hdl.handle.net/10316/79698.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2018/09/28 Neurovascular coupling mediated by neuronal nitric oxide in hippocampus might be sustained by ascorbate and nitrite under hypoxi 4th International Congress of the Serbian Society for Mitochondrial and Free Radical Research
(Belgrade, Sérvia)
2018/09/16 Role of nitric oxide in neurovascular coupling: consequences for aging and neurodegeneration 10th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
(Oxford, Reino Unido)
2018/09/05 Nitric oxide mediated mechanisms in Alzheimer´s disease 8th International Congress of Pathophysiology
(Bratislava, Eslováquia)
2017/06/21 Regulation of neurovascular coupling in the brain by nitrite Oxygen Club California (OCC) and Society for Free Radical Research Europe (SFFRE) meeting “Metabolic Stress and Redox Regulation”
Oxygen Club California (OCC) and Society for Free Radical Research Europe (SFFRE) (Berlin, Alemanha)
2016/10/22 Neurovascular coupling in brain aging and neurodegeneration: nitric oxide-mediated mechanisms and technological approaches Jagiellonian Centre for Experimental Therapeutics (JCET)
(Kraków, Polónia)
2016/06/15 Neurometabolic coupling in hippocampus mediated by neuronal-derived nitric oxide 5th International Iberian Biophysics Congress
(Porto, Portugal)
2016/05/04 Neurovascular coupling mediated by nitric oxide in hippocampus: functional communication with ascorbate and nitrite Oxygen Club California (OCC) World Congress, “Redox Medicine and Nutrition
(Davis, CA, Estados Unidos)
2016/04/11 Nitric oxide in the brain: neuromodulatory roles in the hippocampus in health, disease and aging COST Action BM1203
(Lisbon, Portugal)
2015/09/02 Nitrite supports neurovascular coupling via redox coupling with ascorbate Meeting of the Society for Free Radical Research, Europe (SFRRe) and The Society of Nutrition and Food Science. “Redox Biology meets Nutrition”
(Stuttgart, Alemanha)
2015/08/24 Nitric oxide-mediated neurovascular coupling in healthy and diseased brain: sources, mechanisms and significance 23rd Congress of the International Union for Biochemistry and Molecular Biology (IUBMB) and 44th Annual meeting of the Brazilian Society for Biochemistry and Molecular Biology
International Union for Biochemistry and Molecular Biology and Brazilian Society for Biochemistry and Molecular Biology (Foz do Iguaçu, Brasil)
2015/07/04 Neurovascular coupling mediated by nitric oxide: mechanisms in Alzheimer disease, aging and metabolic acidosis 40th Congress of the Federation European Biochemical Societies (FEBS), The Biochemical basis of life
ederation European Biochemical Societies (FEBS) (Berlin, Alemanha)
2014/06/02 Dysfunctional nitric oxide-mediated neurovascular coupling in Alzheimer´s disease and aging International Sympoisum on Redox Signaling in Biology & Medicine
X Meeting of the Spanish group of Free Radical Research (Valencia, Espanha)
2013/11/04 Coupling neuronal activity with local blood flow in normal and Alzheimer´s rat brain: the direct role of nitric oxide XII Congress Panamerican Association for Biochemistry and Molecular Biology (PABMB)
(Puerto Varas, Chile)
2013/10/16 The nitrate:nitrite:nitric oxide and signaling pathways in the gut: the prominet role of polyphenols VI International Conference on Polyphenols and Health
(Buenos Aires, Argentina)
2013/10/13 Neurovascular coupling: a self-controlled mechanism critical for brain function prone to dysfunction in Alzheimer´s disease and during aging VIII Intrenational Congresso of the Society for Free Radical Biology and Medicine – South American Group
(Buenos Aires, Argentina)
2013/06/23 Neurovascular coupling mediated by nitric oxide in the brain: impact in aging and Alzheimer´s disease 7th International Symposium on Experimental and Clinical Neurobiology
Slovak Academy of Sciences (Kosice , Eslováquia)
2013/04/14 Neurovascular coupling in brain aging and neurodegeneration: a neuronal nitric oxide-driven process Gordon Research Conference on The Metabolic-Inflammatory Axis in Brain Aging and Alzheimer´s disease
(Les Diablerets , Suiça)
2012/09/06 Neurovascular and metabolic coupling: diffusible bridging supported by nitric oxide 16th Biennial Meeting of the Society for Free Radical Research International (SFRRI)
(London, Reino Unido)
2012/06/05 Neurovascular coupling in normal and Alzheimer´s rat brain: the direct role of nitric oxide International Symposium on Redox Signaling and Oxidative Stress in Health and Disease (IV Spanish and Portuguese Meeting on Free Radicals
(Valencia, Espanha)
2011/10/05 Volume signaling in the brain: The proof of concept that neuronal nitric oxide regulates the cerebral microcirculation during neural activity II International Conference on Environmental Stressors in Biology and Medicine
(Siena, Itália)
2011/09/07 Neuronal control of brain blood flow: nitric oxide is the neurovascular mediator with impact in Alzheimer´s disease Redox Biology and micronutrients: from signaling to translation and back
Society for Free Radical Research Europe meeting (Istanbul, Turquia)
2010/11/10 Wireless free radical connections in the brain: nitric oxide dynamics couples neuronal activity with local microcirculation Seminário apresentado no Centro Biología Molecular “Severo Ochoa”
(Madrid, Espanha)
2009/08/26 Nitric oxide mediates the neurovascular coupling between neuronal activity and blood flow in the brain: quantitative, direct and in vivo evidence Society for Free Radical Research Europe
(Rome, Itália)
2009/04/20 Molecular mechanisms inherent to neuromodulation: the role of nitric oxide Conference at Facultad de Medicina, Universidade de la Republica
Facultad de Medicina, Universidade de la Republica (Montevideo, Uruguai)
2008/07/08 Translation of chemical properties of polyphenols into biological activity with impact in human health XXIV International Conference on Polyphenols
(Salamanca, Espanha)
2008/07/05 Nitrite in nitric oxide biology in the stomach: impact of red wine Society for Free Radical Research Europe Meeting 2008, Free Radicals and Nutrition; Basic Mechanisms and Clinical Application
(Berlin, Alemanha)
2007/09/02 Dynamics of nitric oxide and oxygen changes in the hippocampus V Meeting of Society Free Radical Biology and Medicine – South American Group. V International Conference on Peroxynitrite and Reactive Nitrogen Species
(Montevideo, Uruguai)
2007/05/19 Monitoring brain nitric oxide formation and respiration 17th European Society for Neurochemistry Meeting – 3rd Conference on Advances in Molecular Mechanisms of Disease
European Society for Neurochemistry (Salamanca, Espanha)
2007/01/31 Gastric nitric oxide: production and biological impact VIII Reunión del Grupo Espanol de Radicales Libres
(Valencia, Espanha)
2005/09/07 Nitric oxide dynamics in hippocampus following activation of NMDA and AMPA receptors Oxygen Club California and University of Turin meeting “Oxidants and Antioxidants in Biology”
Oxygen Club California and University of Turin meeting (Alba, Itália)
2004/11/25 Redox activity of phenolic antioxidants and the potential benefits for human health 2nd Spanish and Portuguese Congress on Free Radicals
(Leioa-Bizkaia , Espanha)
2004/05/05 Subregional concentration dynamics of nitric oxide in hippocampal slices evoked by stimulation of glutamate NMDA receptor Biennial Meeting of the Society for Free Radical Research International
Society for Free Radical Research (Buenos Aires, Argentina)
2004/05/04 Concentration dynamics of nitric oxide in rat hippocampal sub regions evoked by stimulation of NMDA glutamate receptor using electrochemical microsensors Inaugural Symposium of the Center for Free Radical and Biomedical Research
Facultad de Medicina, Universidad de la República (Montevideo, Uruguai)
2003/02/06 Selective measurement of nitric oxide production evoked by glutamate agonists in rat hippocampal brain slices . Oxygen Club California and University of Cádiz meeting on “Oxidants and Antioxidants in Biology"
Universitiy of Cádiz and Oxygen Club California (Cádiz, Espanha)
2002/09/26 Selective measurement of nitric oxide in rat hippocampal brain slices VII Reunión del Grupo Espanol de Radicales Libres y III Reunión Iberoamericana
Grupo Espanol de Radicales Libres (Cáceres, Espanha)
2002/07/16 Real-time monitoring of nitric oxide in rat hippocampal brain slices XIth Meeting of the Society for Free Radical Research International
Society for Free Radical Research (Paris, França)
2001/10/16 Reaction of nitric oxide with dihydroxyphenylacetic acid: inhibition of mitochondrial respiratory chain 10th Biennial Meeting of the Society for Free Radical Research International
Society for Free Radical Research International (Kyoto, Japão)
2000/11/30 Superoxide dismutase stimulates the oxidation of dopamine metabolites by nitric oxide Winter meeting of the Society for Free Radical Research – Europe
Society for Free Radical Research (Valencia, Espanha)
1999/12/02 Dynamic interplay of phenolic acids and ascorbate in the protection of LDL against oxidation Europe Winter Meeting: Bio-flavonoids and polyphenols in health and disease
Society for Free Radical Research (SFRR) (Dinard, França)
1999/03/03 Redox cycles of caffeic acid during the oxidation of LDL World Congress On Oxidants and Antioxidants in Biology
Oxygen Club of California (Santa Barbara, Estados Unidos)
1994/02/04 Interaction of dietary hydroxycinnamic acid derivatives with ferrylmyoglobin: antioxidant activity towards LDL oxidation Annual Joint Meeting University of California at Berkeley and University of Southern California “Oxidants & Antioxidants in Biology. New Developments in Research and Health Effects”
University of California at Berkeley and University of Southern California (Pasadena, Estados Unidos)
1993/09/30 Reduction of ferrylmyoglobin by dietary phenolic acids: prevention of low density lipoprotein oxidation International Symposium on “Antioxidants, Inflammation, Cardiovascular and Ophtalmic Diseases. Biochemical and Clinical Studies on the Effects of Antioxidants on Lipoprotein and Hemoprotein Oxidation"
(Valencia, Espanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019 - Atual PhD thesis: Improvement of cognition via functional maintenance of neurovascular coupling by dietary nitrite
Orientador
2015 - Atual PhD thesis: Nitrite and neurovascular coupling in the brain: modulation and effects on aging and neurodegeneration
Orientador
Universidade de Coimbra, Portugal
2012 - 2018 Post-doc: Neuronal control of brain blood flow: nitric oxide as the neurovascular and neurometabolic coupler with impact in Alzheimer´s disease and aging.
Orientador
2010 - 2016 PhD thesis: The interplay of ascorbic acid, nitric oxide and nitrite in the brain and its role on the regulation of cerebral blood flow: an in vivo electrochemical study
Orientador
Universidade de Coimbra, Portugal
2009 - 2016 PhD thesis: The role of nitrite-derived nitric oxide in gastric physiology: biochemical mechanisms, molecular targets and the modulatory effect of red wine.
Orientador
Universidade de Coimbra, Portugal
2011 - 2015 Post-doc: Modulators of nitric oxide bioactivity in the nervous system.
Orientador
2009 - 2015 Post-doc: Prevention of inflammatory processes in the gastrointestinal epithelia by dietary flavonoids via modulation of Nrf2 and nitric oxide metabolism
Orientador
2012 - 2014 Post-doc: Glutamatergic activity and nitric oxide production in vivo in the rat brain: modulation of oxygen bioavailability in brain physiology, aging and neurodegeneration.
Orientador
2011 - 2012 Post-doc: Nitric oxide dynamics in aging brain
Orientador
2008 - 2012 PhD thesis: Biological role of nitrite and nitric oxide in the stomach: cellular dysfunction and production of physiologically-active molecules
Orientador
Universidade de Coimbra, Portugal
2008 - 2012 PhD thesis: Interplay between sirtuins and nitric oxide in metabolic syndrome: is PGC-1 alpha a commom mediator for mitochondrial biogenesis?
Coorientador
2007 - 2011 PhD thesis: Nitric oxide production, diffusion and inactivation in the rat brain: In vivo studies using micreloectrodes
Orientador
 PhD (Doutoramento)
2007 - 2011 PhD thesis: In vivo nitric oxide concentration dynamics induced by glutamatergic neuronal activation in rat brain and its role in neurovascular coupling
Orientador
 PhD (Doutoramento)
2004 - 2008 PhD thesis: Nitrite in nitric oxide Biology in the stomach: the role of polyphenols and ethanol
Orientador
 PhD (Doutoramento)
2006 - 2007 Post-doc: Bioavalability of nitric oxide in the cardiovascular system using microelectrodes.
Orientador
2002 - 2006 PhD thesis: Novas vias de morte celular com implicações na doença de Parkinson envolvendo o óxido nítrico e o metabolismo da dopamina
Orientador
 PhD (Doutoramento)
Universidade de Coimbra, Portugal
2001 - 2005 PhD thesis: Real-time change of nitric oxide in rat hippocampal slices and astrocytic gluthathione release via glutamate-dependent pathways
Orientador
 PhD (Doutoramento)
Universidade de Coimbra, Portugal
2000 - 2005 PhD thesis: Modulação da Concentração de Óxido Nítrico em Fatias de Cérebro por Oxidantes e Antioxidantes: Implicações na Vida e na Morte das Células
Orientador
 PhD (Doutoramento)
Universidade de Coimbra, Portugal
1996 - 1996 Post-doc: Application of Parinaric acid fluorescence technology to evaluate the antioxidant activity of flavonoids from tea and wine against LDL oxidized with ferrylmyoglobin
Orientador
1996 - 1996 Post-doc: Implications of LDL oxidized with ferrylmyoglobin against energetic status of isolated hepatocytes; hypothetical protective effect of caffeic acid.
Orientador

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2018/06 - Atual Chair of the 19th meeting of International Society for Free Radical Research (SFRRI) (2018/06/04 - 2018/06/07)
Congresso (Presidente da Comissão Organizadora)
2005 - Atual Chair of the European Meeting of the Society for Free radical Research - Europe (2005)
Congresso
2018 - 2018 International conference on the Biology, Chemistry and Therapeutic applications of nitric oxide. Co-organization of a symposium (with Giovanni Mann, Kings College, London) on: Nitric oxide and vascular redox signaling in health and disease. University of Oxford, UK, September 16-20, 2018. (2018 - 2018)
2015 - 2015 Oxygen Club of California World Congress (OCC 2015). Oxidants and Antioxidants in Biology. Jointly organized by the Portuguese Oxidative Stress Group of SPB (João Laranjinha), the Spanish Group of Free Radicals (GEIRLI) (Juan Sastre) and the Société Française de Recherche sur le Radicaux Libres (Josiane Cillard). Valencia (Spain) June 24-26, 2015. (2015 - 2015)
2012 - 2012 International Symposium on Redox Siganling and Oxidative Stress in Health and Disease (IV Spanish and Portuguese meeting on free radicals). Jointly organized by the Spanish Group of Free Radicals (GEIRLI) and the Portuguese Oxidative Stress Group of SPB. Valencia (Spain) June 5-7, 2012. (2012 - 2012)
2012 - 2012 Society for Free Radical Research International, 16TH Biennial Meeting, 6-9 September 2012, London, UK. Symposium co-organiser on: “Inflammation and neurodegeneration”. (2012 - 2012)
2010 - 2010 Survival or Death as a Matter of Fat. 6th Edition of the International courses of Toxicology at Center for Neurosciences and Cell Biology. Com Alexander Carpinteiro, Antonio Vidal-Puig, Peter Vandenabeele, Erich Gulbins, Faustino Molinedo, Manuel Prieto e Jan Kopecky, Ole Mouritsen, Vìtor Madeira Paavo Kinnunen, e Valerian Kagan. (May 11-14, 2010). (2010 - 2010)
2010 - 2010 IV Luso-Spanish meeting on Free Radicals in Biomedicine and International Symposium on the pathophysiology of reactive oxygen and nitrogen species, organized co-jointly by the Grupo de Stresse Oxidativo of SPB and by Grupo Espanol Radicales Libres. Salamanca (May 19-21, 2010). (2010 - 2010)
2009 - 2009 1Mitochondria: between life and death. 5th Edition of the International courses of Toxicology at Center for Neurosciences and Cell Biology. com Vladimir Skulachev, Robert Lightowlers, Enrique Cadenas, Fabio di Lisa, David Nichols, Dean Jones, Mauro Esposti, Michael Duchen, Vìtor Madeira e Paula Ludovico. Coimbra 5-8 Maio 2009. (2009 - 2009)
2008 - 2008 Metabolic Toxicology: from pathway to organism. 4rd Edition of the International courses of Toxicology at Center for Neurosciences and Cell Biology. (com Elaine Holmes, Yvonne will, Vítor Madeira, Maria de Lourdes Bastos, Carlos Palmeira, Rui Carvalho and Piero Portincasa). Coimbra 9-11 Abril 2008. (2008 - 2008)
2007 - 2007 Stem cells as a tool in toxicology. 3rd Edition of the International courses of Toxicology at Center for Neurosciences and Cell Biology. (com Ernest Arenas, Sérgio Dias, Horst Spielmann and Edward Perkins). Coimbra 21-23 Março 2007. (2007 - 2007)
2007 - 2007 Society for Free Radical Research – Europe (SFRRe) 2007 meeting. Chair. Vilamoura, October 10-13, 2007. (2007 - 2007)
2006 - 2006 Smart Toxicology: Subcellular Targets of Anti-cancer Therapy. 2nd Edition of the International courses of Toxicology at Center for Neurosciences and Cell Biology. (com Sten Orrenius, Ulf R. Rapp, Catherine Brenner, Jon Holy). Coimbra 22-24 Março 2006. (2006 - 2006)
2005 - 2005 Mitochondria: between life and death. International courses of Toxicology at Center for Neurosciences and Cell Biology. (com V. Skulachev, E. Cadenas, G. Cortopassi and F. di Lisa). Coimbra 27-29 Abril 2005. (2005 - 2005)
2004 - 2004 52nd Spanish and Portuguese Congress on Free Radicals, Leioa-Bizkaia (Spain), November 25-27, 2004. (2004 - 2004)
2003 - 2003 First Luso-Spanish Congress on Free Radicals & 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine. Coimbra, December 4-6, 2003. (2003 - 2003)
2000 - 2000 3. Winter Meeting of the Society for Free Radical Research – Europe. Valencia (Spain). “Challenges in Free Radical Research”. Nov. 30 – Dec. 2, 2000. (2000 - 2000)
1994 - 1994 FEBS Advanced Course “Peroxidation in Biomembranes” FEBS Advanced Course and Study Centre of the ESF Network “Molecular Dynamics of Biomembranes”. Co-organizador. Abril 6-15, 1994. (2000 - 2000)
1991 - 1991 Advanced Course “Oxidative Stress on Lipid-Protein Interactions” Universidade de Coimbra. Co-organizador. Outubro 7-19, 1991. (1991 - 1991)

Arbitragem científica em conferência

Nome da conferência Local da conferência
2004 - Atual Member of more than 20 international scientific committees of International Meetings (Europe and US)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019/01/01 - Atual Biofactors - Editorial Board Wiley & Sons
2015/01/01 - Atual Free Radical Research - Editorial Board Taylor & Francis
2014/01/01 - Atual Free Radical Biology and Medicine - Editorial Board Elsevier
2014/01/01 - Atual Archives of Biochemistry and Biophysics - Editorial Board Elsevier
2013/01/01 - Atual Redox Biology - Editorial Board Elsevier

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2018 - Atual Institute of Biomedical Research of Salamanca (IBSAL), Spain - Member of the External Advisory Committee
1999 - Atual Grant reviewer Welcome Trust, UK, Austrian Science Fund, The Henry Smith Charity, UK, UCL, UK, Agence Nationale de la Recherche, France, Fundação Calouste Gulbenkian, Portugal, Alzheimer´s Society, UKReserach Corporation, USA

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2016 - 2016 Membro do “Grupo de Reflexão sobre o Futuro da Fundação para a Ciência e a Tecnologia” a convite do ministro da Ciência, Tecnologia e Ensino Superior. Dezembro de 2015 e Janeiro de 2016.
2014 - 2014 Guest Editor of Genes and Nutrition for a special issue on Nutrients and Aging (2014, vol 9).
2011 - 2011 Consultor Científico do vídeo educacional “Homeostase da glucose” produzido pela empresa Take de Wind, lda, (IPN, Coimbra) no âmbito de um projecto de elaboração de conteúdos multimédia em Bioquímica (2011).
2005/03 - 2005/03 Guest Editor of a special issue of Toxicology (Official Journal of the British and German Toxicological Societies) on Nitric Oxide Cell Signaling and Death. (12 chapters) Toxicology, volume 208, No.2, 15 March 2005.

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
1989 - Atual General Biochemistry Universidade de Coimbra Faculdade de Farmácia, Portugal
1989 - Atual Toxicology and Toxicological Analysis Universidade de Coimbra Faculdade de Farmácia, Portugal
1989 - Atual Molecular Basis of Disease

Membro de associação

Nome da associação Tipo de participação
2019 - Atual The Pan-American association for Biochemistry and Molecular Biology (PABMB) - member of the committee on Congresses and Symposia member of the committee on Congresses and Symposia
2019 - Atual Center for Neurosciences and Cell Biology (CNC), Coimbra - Member of the board of directors
2009 - Atual Oxygen Club California (OCC) Member of the advisory board of Oxygen Club California (OCC)
2015/01/01 - 2018/12/31 Portuguese Biochemical Society (SPB) - President
2015 - 2018 Society for Free Radical Research Europe - Member of the council
2008 - 2016 European Society for Neurochemistry - Member of the council
2013 - 2015 Portuguese Biochemical Society - Vice-president
2012 - 2014 Center for Neurosciences and Cell Biology (CNC), Coimbra - Member of the board of directors
2012 - 2013 New York Academy of Sciences Member
2008 - 2012 Portuguese Biochemical Society - secretary general Secretary General
2007 - 2010 Society for Free Radical Research Europe - Member of the council

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019 - Atual Member elected for the Advanced Courses Committee, FEBS Federation of European Biochemical Societies, Reino Unido
2017 - Atual Doctoral Program Faculty of Pharmacy, University of Coimbra - Coordinator Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/01/01 - Atual The Oxygen Club of California (OCC) is a non-profit scientific organization dedicated to enhancing education and promoting research in the field of oxidants, antioxidants, nutrition, micronutrients and free radicals in biology and medicine with the goal of promoting human health.
Consultor
 The Oxygen Club of California (OCC), Estados Unidos
2013/01/01 - Atual Free Radical Biology and Medicine - Publication Committee member
Consultor
2005 - Atual Member of the Scientific Advisory Board of Institute for Oxidative Stress International
Membro
2005 - Atual Member of the Scientific Advisory Board of Institute for Oxidative Stress International
Membro
2015 - 2018 Member of the European Committee of the Society for Free Radical Research
Membro
2015 - 2018 Member of the Council of the European Society for Neurochemistry
Membro
2016 - 2016 International Society for Neurochemistry - Biennial Program Committee (2016)
Consultor
2007 - 2010 Member of the European Committee of the Society for Free Radical Research
Membro
Distinções

Prémio

2016 Science and Humanity Award by the Oxygen Club of California
The Oxygen Club of California (OCC), Estados Unidos
2015 Lifetime Honorary Member of Oxygen Club of California
Oxygen Club California, Estados Unidos

Outra distinção

2010 Highlighting Portuguese Science
2005 Research Highlight of the paper published in PNAS, Ledo et al. 2005, 12, 17483-88
2003 First prize oral communications, 1º Congresso da Sociedade Port. Ciências Farmacêuticas
1997 First prize Merck Sharp & Dohme VII Portuguese Oral Communications, Congress on Atherosclerosis
1997 1997-1998 Recipient of a post-doc Fellowship from Junta Nacional de Investigação Cientifica (JNICT)
1997 1997-1999 Recipient of a post-doc Fellowship from Luso-American Foundation for Development (FLAD)
Fundação Luso-Americana, Portugal