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Dr David Fulton has interests in polymer and supramolecular chemistry. His research is focused on the development of responsive and adaptable macromolecular assemblies with potential application in molecular recognition and sensing, catalysis, medicine and materials science. All work relies strongly on organic synthesis, NMR, LC-mass spectrometry and HPLC/GPC. Projects have received support from EPSRC, The Royal Society, The EU-framework 7 program, The Nuffield Foundation and Newcastle University. David Fulton. Published 45 articles in journals.
Identificação

Identificação pessoal

Nome completo
David Fulton

Nomes de citação

  • Fulton, David

Identificadores de autor

Ciência ID
3316-EFA2-2CED
ORCID iD
0000-0001-8698-0895

Domínios de atuação

  • Ciências Exatas - Química
Formação
Grau Classificação
2001
Concluído
 PhD University of California, Los Angeles (Doctor of Philosophy)
UCLA Life Sciences, Estados Unidos
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2006 - Atual Professor Associado (Docente Universitário) Newcastle University, Reino Unido
Projetos

Bolsa

Designação Financiadores
2015/04 - 2020/04 Manufacture of complex protein polymers for industry and medicine
grant.BB/M018318/1
 Biotechnology and Biological Sciences Research Council
2016/05 - 2019/05 Self-disclosing protective materials using synthetic gene networks
grant.EP/N026683/1
 Engineering and Physical Sciences Research Council
2009/05 - 2014/03 Investigating the Potential Of Polymer-Scaffolded Dynamic Combinatorial Libraries
grant.EP/G066507/1
 Engineering and Physical Sciences Research Council
Produções

Publicações

Artigo em revista
  1. Patrick L. Higgs; Antonio J. Ruiz-Sanchez; Milene Dalmina; Benjamin R. Horrocks; Andrew G. Leach; David A. Fulton. "Enhancing the kinetics of hydrazone exchange processes: an experimental and computational study". Organic & Biomolecular Chemistry (2019): https://doi.org/10.1039/C9OB00058E.
    10.1039/C9OB00058E
  2. Michael E. Bracchi; Gema Dura; David A. Fulton. "The synthesis of poly(arylthiols) and their utilization in the preparation of cross-linked dynamic covalent polymer nanoparticles and hydrogels". Polymer Chemistry (2019): https://doi.org/10.1039/C9PY00057G.
    10.1039/C9PY00057G
  3. Gema Dura; Helen Waller; Piergiorgio Gentile; Jeremy H. Lakey; David A. Fulton. "Tuneable hydrogels of Caf1 protein fibers". Materials Science and Engineering: C 93 (2018): 88-95. https://doi.org/10.1016/j.msec.2018.07.063.
    10.1016/j.msec.2018.07.063
  4. Clare S. Mahon; Christopher J. McGurk; Scott M. D. Watson; Martin A. Fascione; Chadamas Sakonsinsiri; W. Bruce Turnbull; David A. Fulton. "Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films". Angewandte Chemie 129 42 (2017): 13093-13098. https://doi.org/10.1002/ange.201706379.
    10.1002/ange.201706379
  5. Ruiz-Sanchez, A.J.; Higgs, P.L.; Peters, D.T.; Turley, A.T.; Dobson, M.A.; North, A.J.; Fulton, D.A.. "Probing the Surfaces of Biomacromolecules with Polymer-Scaffolded Dynamic Combinatorial Libraries". ACS Macro Letters 6 9 (2017): 903-907. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029707698&partnerID=MN8TOARS.
    10.1021/acsmacrolett.7b00561
  6. Mahon, C.S.; McGurk, C.J.; Watson, S.M.D.; Fascione, M.A.; Sakonsinsiri, C.; Turnbull, W.B.; Fulton, D.A.. "Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films". Angewandte Chemie - International Edition 56 42 (2017): 12913-12918. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029010003&partnerID=MN8TOARS.
    10.1002/anie.201706379
  7. Borah, D.; Cummins, C.; Rasappa, S.; Watson, S.M.D.; Pike, A.R.; Horrocks, B.R.; Fulton, D.A.; et al. "Nanoscale silicon substrate patterns from self-assembly of cylinder forming poly(styrene)-block-poly(dimethylsiloxane) block copolymer on silane functionalized surfaces". Nanotechnology 28 4 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85007440151&partnerID=MN8TOARS.
    10.1088/1361-6528/28/4/044001
  8. Ulusu, Y.; Dura, G.; Waller, H.; Benning, M.J.; Fulton, D.A.; Lakey, J.H.; Peters, D.T.. "Thermal stability and rheological properties of the 'non-stick' Caf1 biomaterial". Biomedical Materials (Bristol) 12 5 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85030176454&partnerID=MN8TOARS.
    10.1088/1748-605X/aa7a89
  9. Ventura, C.; Guerin, A.J.; El-Zubir, O.; Ruiz-Sanchez, A.J.; Dixon, L.I.; Reynolds, K.J.; Dale, M.L.; et al. "Marine antifouling performance of polymer coatings incorporating zwitterions". Biofouling (2017): 1-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-85032690676&partnerID=MN8TOARS.
    10.1080/08927014.2017.1383983
  10. Upson, S.J.; Partridge, S.W.; Tcacencu, I.; Fulton, D.A.; Corbett, I.; German, M.J.; Dalgarno, K.W.. "Development of a methacrylate-terminated PLGA copolymer for potential use in craniomaxillofacial fracture plates". Materials Science and Engineering C 69 (2016): 470-477. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978173244&partnerID=MN8TOARS.
    10.1016/j.msec.2016.06.012
  11. Fulton, D.A.. "Synthesis: Click chemistry gets reversible". Nature Chemistry 8 10 (2016): 899-900. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988526127&partnerID=MN8TOARS.
    10.1038/nchem.2626
  12. Bracchi, M.E.; Fulton, D.A.. "Orthogonal breaking and forming of dynamic covalent imine and disulfide bonds in aqueous solution". Chemical Communications 51 55 (2015): 11052-11055. http://www.scopus.com/inward/record.url?eid=2-s2.0-84933073644&partnerID=MN8TOARS.
    10.1039/c5cc02716k
  13. Mahon, C.S.; Fascione, M.A.; Sakonsinsiri, C.; McAllister, T.E.; Bruce Turnbull, W.; Fulton, D.A.. "Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins". Organic and Biomolecular Chemistry 13 9 (2015): 2756-2761. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923359251&partnerID=MN8TOARS.
    10.1039/c4ob02587c
  14. Mahon, C.S.; Fulton, D.A.. "Mimicking nature with synthetic macromolecules capable of recognition". Nature Chemistry 6 8 (2014): 665-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904817974&partnerID=MN8TOARS.
    10.1038/nchem.1994
  15. Harun, N.A.; Horrocks, B.R.; Fulton, D.A.. "Enhanced Raman and luminescence spectra from co-encapsulated silicon quantum dots and Au-Ag nanoalloys". Chemical Communications 50 82 (2014): 12389-12391. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907828177&partnerID=MN8TOARS.
    10.1039/c4cc06438k
  16. Sanchez-Sanchez, A.; Fulton, D.A.; Pomposo, J.A.. "PH-responsive single-chain polymer nanoparticles utilising dynamic covalent enamine bonds". Chemical Communications 50 15 (2014): 1871-1874. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893096223&partnerID=MN8TOARS.
    10.1039/c3cc48733d
  17. Whitaker, D.E.; Mahon, C.S.; Fulton, D.A.. "Thermoresponsive dynamic covalent single-chain polymer nanoparticles reversibly transform into a hydrogel". Angewandte Chemie - International Edition 52 3 (2013): 956-959. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872306392&partnerID=MN8TOARS.
    10.1002/anie.201207953
  18. Harun, N.A.; Benning, M.J.; Horrocks, B.R.; Fulton, D.A.. "Gold nanoparticle-enhanced luminescence of silicon quantum dots co-encapsulated in polymer nanoparticles". Nanoscale 5 9 (2013): 3817-3827. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876706102&partnerID=MN8TOARS.
    10.1039/c3nr00421j
  19. Omedes Pujol, M.; Coleman, D.J.L.; Allen, C.D.; Heidenreich, O.; Fulton, D.A.. "Determination of key structure-activity relationships in siRNA delivery with a mixed micelle system". Journal of Controlled Release 172 3 (2013): 939-945. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887202988&partnerID=MN8TOARS.
    10.1016/j.jconrel.2013.10.013
  20. Jackson, A.W.; Fulton, D.A.. "Making polymeric nanoparticles stimuli-responsive with dynamic covalent bonds". Polymer Chemistry 4 1 (2013): 31-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875647859&partnerID=MN8TOARS.
    10.1039/c2py20727c
  21. Mahon, C.S.; Fulton, D.A.. "Templation-induced re-equilibration in polymer-scaffolded dynamic combinatorial libraries leads to enhancements in binding affinities". Chemical Science 4 9 (2013): 3661-3666. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886840223&partnerID=MN8TOARS.
    10.1039/c3sc51413g
  22. Mahon, C.S.; Jackson, A.W.; Murray, B.S.; Fulton, D.A.. "Investigating templating within Polymer-Scaffolded Dynamic Combinatorial Libraries". Polymer Chemistry 4 2 (2013): 368-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870939986&partnerID=MN8TOARS.
    10.1039/c2py20600e
  23. Jackson, A.W.; Fulton, D.A.. "Triggering polymeric nanoparticle disassembly through the simultaneous application of two different stimuli". Macromolecules 45 6 (2012): 2699-2708. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859177827&partnerID=MN8TOARS.
    10.1021/ma202721s
  24. Jackson, A.W.; Fulton, D.A.. "PH triggered self-assembly of core cross-linked star polymers possessing thermoresponsive cores". Chemical Communications 47 24 (2011): 6807-6809. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959790196&partnerID=MN8TOARS.
    10.1039/c1cc11785h
  25. Murray, B.S.; Fulton, D.A.. "Dynamic covalent single-chain polymer nanoparticles". Macromolecules 44 18 (2011): 7242-7252. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053043070&partnerID=MN8TOARS.
    10.1021/ma201331f
  26. Jackson, A.W.; Stakes, C.; Fulton, D.A.. "The formation of core cross-linked star polymer and nanogel assemblies facilitated by the formation of dynamic covalent imine bonds". Polymer Chemistry 2 11 (2011): 2500-2511. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054013860&partnerID=MN8TOARS.
    10.1039/c1py00261a
  27. Harun, N.A.; Horrocks, B.R.; Fulton, D.A.. "A miniemulsion polymerization technique for encapsulation of silicon quantum dots in polymer nanoparticles". Nanoscale 3 11 (2011): 4733-4741. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856435929&partnerID=MN8TOARS.
    10.1039/c1nr10938c
  28. Mahon, C.S.; Jackson, A.W.; Murray, B.S.; Fulton, D.A.. "Templating a polymer-scaffolded dynamic combinatorial library". Chemical Communications 47 25 (2011): 7209-7211. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959806719&partnerID=MN8TOARS.
    10.1039/c1cc11998b
  29. Jackson, A.W.; Fulton, D.A.. "The formation of core cross-linked star polymers containing cores cross-linked by dynamic covalent imine bonds". Chemical Communications 46 33 (2010): 6051-6053. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955816678&partnerID=MN8TOARS.
    10.1039/c0cc00691b
  30. Jackson, A.W.; Fulton, D.A.. "Dynamic covalent diblock copolymers prepared from RAFT generated aldehyde and alkoxyamine end-functionalized Polymers". Macromolecules 43 2 (2010): 1069-1075. http://www.scopus.com/inward/record.url?eid=2-s2.0-74849108293&partnerID=MN8TOARS.
    10.1021/ma902291a
  31. Murray, B.S.; Jackson, A.W.; Mahon, C.S.; Fulton, D.A.. "Reactive thermoresponsive copolymer scaffolds". Chemical Communications 46 45 (2010): 8651-8653. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149445496&partnerID=MN8TOARS.
    10.1039/c0cc03856c
  32. Henderson, J.R.; Fulton, D.A.; McNeil, C.J.; Manning, P.. "The development and in vitro characterisation of an intracellular nanosensor responsive to reactive oxygen species". Biosensors and Bioelectronics 24 12 (2009): 3608-3614. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650090502&partnerID=MN8TOARS.
    10.1016/j.bios.2009.05.029
  33. Fulton, D.A.. "Dynamic combinatorial libraries constructed on polymer scaffolds". Organic Letters 10 15 (2008): 3291-3294. http://www.scopus.com/inward/record.url?eid=2-s2.0-49649109104&partnerID=MN8TOARS.
    10.1021/ol8011309
  34. Thompson, A.L.; Parker, D.; Fulton, D.A.; Howard, J.A.K.; Pandya, S.U.; Puschmann, H.; Senanayake, K.; et al. "On the role of the counter-ion in defining water structure and dynamics: Order, structure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes". Dalton Transactions 47 (2006): 5605-5616. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846312485&partnerID=MN8TOARS.
    10.1039/b606206g
  35. Fulton, D.A.; Elemento, E.M.; Aime, S.; Chaabane, L.; Botta, M.; Parker, D.. "Glycoconjugates of gadolinium complexes for MRI applications". Chemical Communications 10 (2006): 1064-1066. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644767065&partnerID=MN8TOARS.
    10.1039/b517997a
  36. Fulton, D.A.; O'Halloran, M.; Parker, D.; Senanayake, K.; Botta, M.; Aime, S.. "Efficient relaxivity enhancement in dendritic gadolinium complexes: Effective motional coupling in medium molecular weight conjugates". Chemical Communications 4 (2005): 474-476. http://www.scopus.com/inward/record.url?eid=2-s2.0-13244258348&partnerID=MN8TOARS.
    10.1039/b413536a
  37. Lowe, J.N.; Fulton, D.A.; Chiu, S.-H.; Elizarov, A.M.; Cantrill, S.J.; Rowan, S.J.; Stoddart, J.F.. "Polyvalent interactions in unnatural recognition processes". Journal of Organic Chemistry 69 13 (2004): 4390-4402. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042701770&partnerID=MN8TOARS.
    10.1021/jo030283o
  38. Fulton, D.A.; Cantrill, S.J.; Stoddart, J.F.. "Probing polyvalency in artificial systems exhibiting molecular recognition". Journal of Organic Chemistry 67 23 (2002): 7968-7981. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037111599&partnerID=MN8TOARS.
    10.1021/jo0110799
  39. Fulton, D.A.; Stoddart, J.F.. "Synthesis of cyclodextrin-based carbohydrate clusters by photoaddition reactions". Journal of Organic Chemistry 66 25 (2001): 8309-8319. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035861618&partnerID=MN8TOARS.
    10.1021/jo010705z
  40. Fulton, D.A.; Stoddart, J.F.. "Neoglycoconjugates based on cyclodextrins and calixarenes". Bioconjugate Chemistry 12 5 (2001): 655-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034803094&partnerID=MN8TOARS.
    10.1021/bc0100410
  41. Fulton, D.A.; Pease, A.R.; Stoddart, J.F.. "Cyclodextrin-based carbohydrate clusters by amide bond formation". Israel Journal of Chemistry 40 3-4 (2000): 325-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034558963&partnerID=MN8TOARS.
  42. Fulton, D.A.; Stoddart, J.F.. "An efficient synthesis of cyclodextrin-based carbohydrate cluster compounds". Organic Letters 2 8 (2000): 1113-1116. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034689844&partnerID=MN8TOARS.
  43. Cantrill, S.J.; Fulton, D.A.; Heiss, A.M.; Pease, A.R.; Stoddart, J.F.; White, A.J.P.; Williams, D.J.. "The influence of macrocyclic polyether constitution upon ammonium ion/crown ether recognition processes". Chemistry - A European Journal 6 12 (2000): 2274-2287. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034674339&partnerID=MN8TOARS.
  44. Cantrill, S.J.; Fulton, D.A.; Fyfe, M.C.T.; Stoddart, J.F.; White, A.J.P.; Williams, D.J.. "A new protocol for rotaxane synthesis". Tetrahedron Letters 40 19 (1999): 3669-3672. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033532127&partnerID=MN8TOARS.
    10.1016/S0040-4039(99)00555-9
  45. Fulton, D.A.; Gibson, C.L.. "Synthesis of a scalemic ß-amino disulfide from (S)-phenylglycine and (R)-styrene oxide and use as a catalyst in enantioselective additions of diethylzinc to aldehydes". Tetrahedron Letters 38 11 (1997): 2019-2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031575745&partnerID=MN8TOARS.
    10.1016/S0040-4039(97)00221-9

Outros

Outra produção
  1. Cell-free genetic devices confer autonomic and adaptive properties to hydrogels. 2019. Colette J. Whitfield; Alice M. Banks; Gema Dura; John Love; Jonathan E. Fieldsend; Sarah A. Goodchild; David A. Fulton; Thomas P. Howard. https://doi.org/10.1101/2019.12.12.872622.
    10.1101/2019.12.12.872622