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My research focuses on the eco-evolutionary mechanisms that influence genetic diversity and its variations at the genome scale and in space. It spans micro- and macro-evolutionary timescales, starting with intra-population mechanisms and extending to the study of divergence leading to speciation, and finally to molecular evolution between isolated species. To study these different levels, I use concepts and analysis methods from population genetics and apply them to polymorphism data produced using genome sequencing technologies. My study models are mainly fish and marine invertebrates. Although essentially fundamental, my research has applications in aquaculture genetic programmes and in the conservation and management of natural populations.
Identificação

Identificação pessoal

Nome completo
Pierre-Alexandre Gagnaire

Nomes de citação

  • Gagnaire, Pierre-Alexandre

Identificadores de autor

Ciência ID
3612-AEB3-3244
ORCID iD
0000-0002-1908-3235

Websites

  • https://cv.archives-ouvertes.fr/pierre-alexandre-gagnaire (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia da Evolução das Espécies

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Francês (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2009
Concluído
Population genetics (Doctor of Philosophy)
Université de Montpellier, França
2004 - 2006
Concluído
Cellular and Molecular Biology, Oncology (Master)
École Normale Supérieure de Lyon, França
2002 - 2003
Concluído
Molecular and Cellular Biology (Licence)
École Normale Supérieure de Lyon, França
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2013 - Atual Investigador principal (carreira) (Investigação) Université de Montpellier, França
2011 - 2013 Investigador principal (carreira) (Investigação) Institut des sciences de l'évolution de Montpellier, França
2010 - 2011 Pós-doutorado (Investigação) Université Laval, Canadá
2009 - 2010 Pós-doutorado (Investigação) Université Laval, Canadá
Projetos

Outro

Designação Financiadores
2018/01/03 - 2021/01/03 Comparative Genomics of Divergence for linking speciation to species life-history traits – CoGeDiv
Investigador responsável
Agence nationale de la recherche, França
Em curso
2013/01/03 - 2014/01/03 ArchiGen
Investigador responsável
Concluído
2011/01/03 - 2014/01/03 Labrad-Seq
Investigador responsável
Agence nationale de la recherche, França
Concluído
Produções

Publicações

Artigo em revista
  1. Jade Castel; Stéphane Hourdez; Florence Pradillon; Claire Daguin-Thiebaut; Marion Ballenghien; Stéphanie Ruault; Erwan Corre; et al. "Inter-Specific Genetic Exchange Despite Strong Divergence in Deep-Sea Hydrothermal Vent Gastropods of the Genus Alviniconcha". Genes (2022): https://www.mdpi.com/2073-4425/13/6/985.
    10.3390/genes13060985
  2. Carine Rey; Audrey Darnaude; Franck Ferraton; Bruno Guinand; François Bonhomme; Nicolas Bierne; Pierre-Alexandre Gagnaire. "Within-Generation Polygenic Selection Shapes Fitness-Related Traits across Environments in Juvenile Sea Bream". Genes (2020): https://www.mdpi.com/2073-4425/11/4/398.
    10.3390/genes11040398
  3. Sylvie Lapegue; Serge Heurtebise; Florence Cornette; Erwan Guichoux; Pierre-Alexandre Gagnaire. "Genetic Characterization of Cupped Oyster Resources in Europe Using Informative Single Nucleotide Polymorphism (SNP) Panels". Genes (2020): https://www.mdpi.com/2073-4425/11/4/451.
    10.3390/genes11040451
  4. Leitwein, Maeva; Duranton, Maud; Rougemont, Quentin; Gagnaire, Pierre-Alexandre; Bernatchez, Louis. "Using Haplotype Information for Conservation Genomics". Trends in Ecology & Evolution 35 3 (2020): 245-258. http://dx.doi.org/10.1016/j.tree.2019.10.012.
    10.1016/j.tree.2019.10.012
  5. Leitwein, Maeva; Cayuela, Hugo; Ferchaud, Anne-Laure; Normandeau, Éric; Gagnaire, Pierre-Alexandre; Bernatchez, Louis. "The role of recombination on genome-wide patterns of local ancestry exemplified by supplemented brook charr populations". Molecular Ecology 28 21 (2019): 4755-4769. http://dx.doi.org/10.1111/mec.15256.
    10.1111/mec.15256
  6. Rougeux, Clément; Gagnaire, Pierre-Alexandre; Praebel, Kim; Seehausen, Ole; Bernatchez, Louis. "Polygenic selection drives the evolution of convergent transcriptomic landscapes across continents within a Nearctic sister species complex". Molecular Ecology 28 19 (2019): 4388-4403. http://dx.doi.org/10.1111/mec.15226.
    10.1111/mec.15226
  7. Saint-Pé, Keoni; Leitwein, Maeva; Tissot, Laurence; Poulet, Nicolas; Guinand, Bruno; Berrebi, Patrick; Marselli, Geoffrey; et al. "Development of a large SNPs resource and a low-density SNP array for brown trout (Salmo trutta) population genetics". BMC Genomics 20 1 (2019): http://dx.doi.org/10.1186/s12864-019-5958-9.
    10.1186/s12864-019-5958-9
  8. Duranton, Maud; Bonhomme, François; Gagnaire, Pierre-Alexandre. "The spatial scale of dispersal revealed by admixture tracts". Evolutionary Applications 12 9 (2019): 1743-1756. http://dx.doi.org/10.1111/eva.12829.
    10.1111/eva.12829
  9. Vandeputte, M.; Gagnaire, P.-A.; Allal, F.. "The European sea bass: a key marine fish model in the wild and in aquaculture". Animal Genetics 50 3 (2019): 195-206. http://dx.doi.org/10.1111/age.12779.
    10.1111/age.12779
  10. Riquet, Florentine; Liautard-Haag, Cathy; Woodall, Lucy; Bouza, Carmen; Louisy, Patrick; Hamer, Bojan; Otero-Ferrer, Francisco; et al. "Parallel pattern of differentiation at a genomic island shared between clinal and mosaic hybrid zones in a complex of cryptic seahorse lineages". Evolution 73 4 (2019): 817-835. http://dx.doi.org/10.1111/evo.13696.
    10.1111/evo.13696
  11. Faggion, Sara; Vandeputte, Marc; Chatain, Béatrice; Gagnaire, Pierre-Alexandre; Allal, François. "Population-specific variations of the genetic architecture of sex determination in wild European sea bass Dicentrarchus labrax L.". Heredity 122 5 (2018): 612-621. http://dx.doi.org/10.1038/s41437-018-0157-z.
    10.1038/s41437-018-0157-z
  12. Gagnaire, Pierre-Alexandre; Lamy, Jean-Baptiste; Cornette, Florence; Heurtebise, Serge; Dégremont, Lionel; Flahauw, Emilie; Boudry, Pierre; Bierne, Nicolas; Lapègue, Sylvie. "Analysis of Genome-Wide Differentiation between Native and Introduced Populations of the Cupped Oysters Crassostrea gigas and Crassostrea angulata". Genome Biology and Evolution 10 9 (2018): 2518-2534. http://dx.doi.org/10.1093/gbe/evy194.
    10.1093/gbe/evy194
  13. Leitwein, Maeva; Gagnaire, Pierre-Alexandre; Desmarais, Erick; Berrebi, Patrick; Guinand, Bruno. "Genomic consequences of a recent three-way admixture in supplemented wild brown trout populations revealed by local ancestry tracts". Molecular Ecology 27 17 (2018): 3466-3483. http://dx.doi.org/10.1111/mec.14816.
    10.1111/mec.14816
  14. Fraïsse, Christelle; Roux, Camille; Gagnaire, Pierre-Alexandre; Romiguier, Jonathan; Faivre, Nicolas; Welch, John J.; Bierne, Nicolas. "The divergence history of European blue mussel species reconstructed from Approximate Bayesian Computation: the effects of sequencing techniques and sampling strategies". PeerJ 6 (2018): e5198. http://dx.doi.org/10.7717/peerj.5198.
    10.7717/peerj.5198
  15. Duranton, Maud; Allal, François; Fraïsse, Christelle; Bierne, Nicolas; Bonhomme, François; Gagnaire, Pierre-Alexandre. "The origin and remolding of genomic islands of differentiation in the European sea bass". Nature Communications 9 1 (2018): http://dx.doi.org/10.1038/s41467-018-04963-6.
    10.1038/s41467-018-04963-6
  16. Souissi, Ahmed; Bonhomme, François; Manchado, Manuel; Bahri-Sfar, Lilia; Gagnaire, Pierre-Alexandre. "Genomic and geographic footprints of differential introgression between two divergent fish species (Solea spp.)". Heredity 121 6 (2018): 579-593. http://dx.doi.org/10.1038/s41437-018-0079-9.
    10.1038/s41437-018-0079-9
  17. Babin, Charles; Gagnaire, Pierre-Alexandre; Pavey, Scott A; Bernatchez, Louis. "RAD-Seq Reveals Patterns of Additive Polygenic Variation Caused by Spatially-Varying Selection in the American Eel (Anguilla rostrata)". Genome Biology and Evolution 9 11 (2017): 2974-2986. http://dx.doi.org/10.1093/gbe/evx226.
    10.1093/gbe/evx226
  18. Rougeux, Clément; Bernatchez, Louis; Gagnaire, Pierre-Alexandre. "Modeling the Multiple Facets of Speciation-with-Gene-Flow toward Inferring the Divergence History of Lake Whitefish Species Pairs (Coregonus clupeaformis)". Genome Biology and Evolution 9 8 (2017): 2057-2074. http://dx.doi.org/10.1093/gbe/evx150.
    10.1093/gbe/evx150
  19. Leitwein, Maeva; Guinand, Bruno; Pouzadoux, Juliette; Desmarais, Erick; Berrebi, Patrick; Gagnaire, Pierre-Alexandre. "A Dense Brown Trout (Salmo trutta) Linkage Map Reveals Recent Chromosomal Rearrangements in theSalmoGenus and the Impact of Selection on Linked Neutral Diversity". G3: Genes|Genomes|Genetics 7 4 (2017): 1365-1376. http://dx.doi.org/10.1534/g3.116.038497.
    10.1534/g3.116.038497
  20. Souissi, Ahmed; Gagnaire, Pierre-Alexandre; Bonhomme, François; Bahri-Sfar, Lilia. "Introgressive hybridization and morphological transgression in the contact zone between two MediterraneanSoleaspecies". Ecology and Evolution 7 5 (2017): 1394-1402. http://dx.doi.org/10.1002/ece3.2533.
    10.1002/ece3.2533
  21. Guinand, B; Chauvel, C; Lechene, M; Tournois, J; Tsigenopoulos, CS; Darnaude, AM; McKenzie, DJ; Gagnaire, PA. "Candidate gene variation in gilthead sea bream reveals complex spatiotemporal selection patterns between marine and lagoon habitats". Marine Ecology Progress Series 558 (2016): 115-127. http://dx.doi.org/10.3354/meps11851.
    10.3354/meps11851
  22. Rougemont, Quentin; Gagnaire, Pierre-Alexandre; Perrier, Charles; Genthon, Clémence; Besnard, Anne-Laure; Launey, Sophie; Evanno, Guillaume. "Inferring the demographic history underlying parallel genomic divergence among pairs of parasitic and nonparasitic lamprey ecotypes". Molecular Ecology 26 1 (2016): 142-162. http://dx.doi.org/10.1111/mec.13664.
    10.1111/mec.13664
  23. Le Moan, A.; Gagnaire, P.-A.; Bonhomme, F.. "Parallel genetic divergence among coastal-marine ecotype pairs of European anchovy explained by differential introgression after secondary contact". Molecular Ecology 25 13 (2016): 3187-3202. http://dx.doi.org/10.1111/mec.13627.
    10.1111/mec.13627
  24. Szulkin, M.; Gagnaire, P.-A.; Bierne, N.; Charmantier, A.. "Population genomic footprints of fine-scale differentiation between habitats in Mediterranean blue tits". Molecular Ecology 25 2 (2016): 542-558. http://dx.doi.org/10.1111/mec.13486.
    10.1111/mec.13486
  25. Miller, Michael J.; Feunteun, Eric; Aoyama, Jun; Watanabe, Shun; Kuroki, Mari; Lecomte-Finiger, Raymonde; Minegishi, Yuki; et al. "Biodiversity and distribution of leptocephali west of the Mascarene Plateau in the southwestern Indian Ocean". Progress in Oceanography 137 (2015): 84-102. http://dx.doi.org/10.1016/j.pocean.2015.05.026.
    10.1016/j.pocean.2015.05.026
  26. Gagnaire, Pierre-Alexandre; Broquet, Thomas; Aurelle, Didier; Viard, Frédérique; Souissi, Ahmed; Bonhomme, François; Arnaud-Haond, Sophie; Bierne, Nicolas. "Using neutral, selected, and hitchhiker loci to assess connectivity of marine populations in the genomic era". Evolutionary Applications 8 8 (2015): 769-786. http://dx.doi.org/10.1111/eva.12288.
    10.1111/eva.12288
  27. Tine, Mbaye; Kuhl, Heiner; Gagnaire, Pierre-Alexandre; Louro, Bruno; Desmarais, Erick; Martins, Rute S.T.; Hecht, Jochen; et al. "European sea bass genome and its variation provide insights into adaptation to euryhalinity and speciation". Nature Communications 5 1 (2014): http://dx.doi.org/10.1038/ncomms6770.
    10.1038/ncomms6770
  28. Sevellec, M.; Pavey, S. A.; Boutin, S.; Filteau, M.; Derome, N.; Bernatchez, L.. "Microbiome investigation in the ecological speciation context of lake whitefish (Coregonus clupeaformis) using next-generation sequencing". Journal of Evolutionary Biology 27 6 (2014): 1029-1046. http://dx.doi.org/10.1111/jeb.12374.
    10.1111/jeb.12374
  29. Ulrik, Malene G; Pujolar, José; Ferchaud, Anne-Laure; Jacobsen, Magnus W; Als, Thomas D; Gagnaire, Pierre; Frydenberg, Jane; et al. "Do North Atlantic eels show parallel patterns of spatially varying selection?". BMC Evolutionary Biology 14 1 (2014): 138. http://dx.doi.org/10.1186/1471-2148-14-138.
    10.1186/1471-2148-14-138
  30. Gagnaire, Pierre-Alexandre; Pavey, Scott A.; Normandeau, Eric; Bernatchez, Louis. "THE GENETIC ARCHITECTURE OF REPRODUCTIVE ISOLATION DURING SPECIATION-WITH-GENE-FLOW IN LAKE WHITEFISH SPECIES PAIRS ASSESSED BY RAD SEQUENCING". Evolution 67 9 (2013): 2483-2497. http://dx.doi.org/10.1111/evo.12075.
    10.1111/evo.12075
  31. Bierne, Nicolas; Gagnaire, Pierre-Alexandre; David, Patrice. "The geography of introgression in a patchy environment and the thorn in the side of ecological speciation". Current Zoology 59 1 (2013): 72-86. http://dx.doi.org/10.1093/czoolo/59.1.72.
    10.1093/czoolo/59.1.72
  32. Côté, Caroline L.; Gagnaire, Pierre-Alexandre; Bourret, Vincent; Verreault, Guy; Castonguay, Martin; Bernatchez, Louis. "Population genetics of the American eel (Anguilla rostrata):FST = 0 and North Atlantic Oscillation effects on demographic fluctuations of a panmictic species". Molecular Ecology 22 7 (2012): 1763-1776. http://dx.doi.org/10.1111/mec.12142.
    10.1111/mec.12142
  33. Gagnaire, Pierre-Alexandre; Normandeau, Eric; Pavey, Scott A.; Bernatchez, Louis. "Mapping phenotypic, expression and transmission ratio distortion QTL using RAD markers in the Lake Whitefish(Coregonus clupeaformis)". Molecular Ecology 22 11 (2012): 3036-3048. http://dx.doi.org/10.1111/mec.12127.
    10.1111/mec.12127
  34. Chaoui, Lamya; Gagnaire, Pierre-Alexandre; Guinand, Bruno; Quignard, Jean-Pierre; Tsigenopoulos, Costas; Kara, M. Hichem; Bonhomme, François. "Microsatellite length variation in candidate genes correlates with habitat in the gilthead sea breamSparus aurata". Molecular Ecology 21 22 (2012): 5497-5511. http://dx.doi.org/10.1111/mec.12062.
    10.1111/mec.12062
  35. Laflamme, Simon; Côté, Caroline; Gagnaire, Pierre-Alexandre; Castonguay, Martin; Bernatchez, Louis. "RNA/DNA ratios in American glass eels (Anguilla rostrata): evidence for latitudinal variation in physiological status and constraints to oceanic migration?". Ecology and Evolution 2 5 (2012): 875-884. http://dx.doi.org/10.1002/ece3.212.
    10.1002/ece3.212
  36. Gagnaire, Pierre-Alexandre; Normandeau, Eric; Bernatchez, Louis. "Comparative Genomics Reveals Adaptive Protein Evolution and a Possible Cytonuclear Incompatibility between European and American Eels". Molecular Biology and Evolution 29 10 (2012): 2909-2919. http://dx.doi.org/10.1093/molbev/mss076.
    10.1093/molbev/mss076
  37. Gagnaire, Pierre-Alexandre; Normandeau, Eric; Côté, Caroline; Møller Hansen, Michael; Bernatchez, Louis. "The Genetic Consequences of Spatially Varying Selection in the Panmictic American Eel (Anguilla rostrata)". Genetics 190 2 (2011): 725-736. http://dx.doi.org/10.1534/genetics.111.134825.
    10.1534/genetics.111.134825
  38. Minegishi, Yuki; Gagnaire, Pierre-Alexandre; Aoyama, Jun; Bosc, Pierre; Feunteun, Eric; Tsukamoto, Katsumi; Berrebi, Patrick. "Present and past genetic connectivity of the Indo-Pacific tropical eel Anguilla bicolor". Journal of Biogeography 39 2 (2011): 408-420. http://dx.doi.org/10.1111/j.1365-2699.2011.02603.x.
    10.1111/j.1365-2699.2011.02603.x
  39. Gagnaire, Pierre-Alexandre; Minegishi, Yuki; Zenboudji, Saliha; Valade, Pierre; Aoyama, Jun; Berrebi, Patrick. "WITHIN-POPULATION STRUCTURE HIGHLIGHTED BY DIFFERENTIAL INTROGRESSION ACROSS SEMIPERMEABLE BARRIERS TO GENE FLOW IN ANGUILLA MARMORATA". Evolution 65 12 (2011): 3413-3427. http://dx.doi.org/10.1111/j.1558-5646.2011.01404.x.
    10.1111/j.1558-5646.2011.01404.x
  40. GAGNAIRE, P. A.; ALBERT, V.; JÓNSSON, B.; BERNATCHEZ, L.. "Natural selection influences AFLP intraspecific genetic variability and introgression patterns in Atlantic eels". Molecular Ecology 18 8 (2009): 1678-1691. http://dx.doi.org/10.1111/j.1365-294x.2009.04142.x.
    10.1111/j.1365-294x.2009.04142.x
  41. Gagnaire, PA; Minegishi, Y; Aoyama, J; Réveillac, E; Robinet, T; Bosc, P; Tsukamoto, K; Feunteun, E; Berrebi, P. "Ocean currents drive secondary contact between Anguilla marmorata populations in the Indian Ocean". Marine Ecology Progress Series 379 (2009): 267-278. http://dx.doi.org/10.3354/meps07895.
    10.3354/meps07895
  42. Robinet, T.; Réveillac, E.; Kuroki, M.; Aoyama, J.; Tsukamoto, K.; Rabenevanana, M. W.; Valade, P.; et al. "New clues for freshwater eels (Anguilla spp.) migration routes to eastern Madagascar and surrounding islands". Marine Biology 154 3 (2008): 453-463. http://dx.doi.org/10.1007/s00227-008-0938-7.
    10.1007/s00227-008-0938-7
  43. Gagnaire, P. A.; Tsukamoto, K.; Aoyama, J.; Minegishi, Y.; Valade, P.; Berrebi, P.. "RFLP and semi-multiplex PCR-based identification of four eel species from the south-western Indian Ocean region". Journal of Fish Biology 71 sb (2007): 279-287. http://dx.doi.org/10.1111/j.1095-8649.2007.01605.x.
    10.1111/j.1095-8649.2007.01605.x
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022 ·Invited national presentations: Prospectives CNRS-INEE
2021 Invited international presentations: FSBI Symposium, Keynote
2021 ·Invited international presentations: , CeMEB Autumn Assembly, Keynote
2021 ·Invited national presentations: ESEminaires
2021 ·Invited national presentations: MARBEC seminar
2021 ·Invited national presentations: MOI seminar
2019 ·Invited national presentations: EEP lab seminar

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2019 - 2023 Evolution des paysages de recombinaison chez les animaux
Orientador
2019 - 2023 Génomique comparative de la divergence écotypique associée au gradient laguno-marin chez cinq espèces de poissons
Orientador
2018 - 2022 Rôles des contraintes génomiques et des traits d'histoire de vie dans la spéciation : une approche de génomique comparative
Orientador
2016 - 2019 Intégrer des approches expérimentales et d’évolution moléculaire en génomique de la spéciation afin d’identifier les mécanismes impliqués dans la divergence entre bar atlantique et loup méditerranéen
Orientador

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2022 - Atual ·Symposium co-organisation on the Evolution of recombination genomic landscapes at the ESEB 2022 congress in Prague with Milan Malinsky. (2022)

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2019 - Atual Invited international presentations: iMARCO Conference
Conferência

Comissão de avaliação

Descrição da atividade
Tipo de assessoria
Instituição / Organização Entidade financiadora
2022 - Atual ·Scientific project evaluator: Icelandic Research Fund (2022)
2022 - Atual ·Scientific project evaluator: NERC (2022).
2021 - Atual ·Scientific project evaluator: Atlantic Genome Canada (2021)
2020 - Atual Scientific project evaluator: Austrian Science Fund FWF
2020 - Atual ·Scientific project evaluator: ERC Consolidator (2020)

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019 - 2023 Master 1 BEE Darwin: Co-organizer of the GGE module.