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I hold a Pharmaceutical degree at the University of Santa Cruz do Sul - UNISC (2005). A PhD and a post doctoral degree in Pharmaceutical Sciences, both of which attributed by the University of Eberhard Karls in Tübingen (Germany), department of Medicinal chemistry in 2010 and 2011, respectively. I also hold a post doctoral degree in Health Sciences by the Federal University of Mato Grosso (UFMT), Department of Pharmacology of the Faculty of Medicine (2012). I am currently an senior research scientist in University Hospital of Tuebingen (Germany), invited associated professor and researcher in the Division of Pharmaceutical and Medicinal Chemistry at the University of Tübingen in Germany. Also, I'am a invited teacher in the post graduation program in Biotechnology and post graduation program in Medical Sciences, both at the University of Vale do Taquari - UNIVATES. My scientific work comprises the fields of Pharmacy, focusing on Biochemistry, Pharmaceutical Chemistry and Pharmacology of natural and synthetic products. My research is mainly focused on the development and validation of bioassays for the quantitative determination and identification of the biological activity of isolated compounds, medicinal plants extracts and small molecules with anti-inflammatory and antitumoral activity, structure-activity relation and production control of pharmaceuticals under the GMP norms. Nowadays, I assess the biotechnological and pharmaceutical potential of natural/derivated and synthetic products, aiming the identification and characterization of the cellular and molecular processes involved in the action mechanism for the development of novel pharmaceutical products. However, my main research target is a class of proteins, known as MAPKs (eg, p38, JNK, ERK), which are frequently deregulated in human diseases such as cancers and inflammatory diseases, and are promising targets in the development of targeted therapies. I am co-author of 62 publications in peer-reviewed scientific journals, 5 books, 3 book chapters, 3 full publications in international congresses, 1 expanded abstract and 99 abstracts in international congresses, and 74 oral communications in international congresses. Among these, 84 publications in peer-reviewed scientific journals, 7 book, 5 book chapter, 3 full publications in international congresses, 40 abstracts in international congresses, and 39 oral communications in international congresses, were produced in the last five years. I was awarded/distinguished 12 times individually or as team member. I am the author of a patent regarding the therapeutic use of Ceiba speciosa extracts. Since 2003, I have been involved as a researcher in 17 different research projects. To this date, I have supervised 3 PhD thesis, 23 master's dissertations, 15 graduation projects and 22 scientifical initiation projects. Currently, I am orienting and supervising 3 master's dissertations, 2 doctoral thesis and 2 scientifical initiation projects. I have an h-index of 17 and over 987 citations according to scopus.
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Identificação

Identificação pessoal

Nome completo
Márcia Inês Goettert

Nomes de citação

  • Goettert, Márcia

Identificadores de autor

Ciência ID
3711-340F-121F
ORCID iD
0000-0002-3648-5033

Moradas

  • Universidade do Vale do Taquari - UNIVATES. Avenida Avelino Talini, 171 Universitário, 95914014, Lajeado, Rio Grande do Sul, Brasil (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Alemão Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/01/01 - Atual Investigador (Investigação) Universitätsklinikum Tübingen, Alemanha

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2022 - Atual Professor Associado (Docente Universitário) Eberhard Karls Universität Tübingen, Alemanha
Eberhard Karls Universität Tübingen, Alemanha
2020/01/01 - Atual Professor Associado Convidado (Docente Universitário) Universitätsklinikum Tübingen, Alemanha
2020 - 2021 Professor Associado Convidado (Docente Universitário) Eberhard Karls Universität Tübingen, Alemanha
Eberhard Karls Universität Tübingen, Alemanha
2019 - 2020 Professor Associado (Docente Universitário) Universidade do Vale do Taquari, Brasil
Universidade do Vale do Taquari, Brasil
2013 - 2019 Professor Auxiliar (Docente Universitário) Universidade do Vale do Taquari, Brasil
Universidade do Vale do Taquari, Brasil
2013 - 2013 Professor Auxiliar (Docente Universitário) Universidade do Vale do Taquari, Brasil
Universidade do Vale do Taquari, Brasil

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022 - Atual Invited teacher in PPG Medical science Universidade do Vale do Taquari, Brasil
Universidade do Vale do Taquari, Brasil
2022 - Atual Senior research scientist - University Hospital of Tuebingen, UKT, Germany Eberhard Karls Universität Tübingen, Alemanha
Eberhard Karls Universität Tübingen, Alemanha
2022 - Atual Scientific Coordinator - Brasil and Latin America Center - University of Tübingen, Germany Eberhard Karls Universität Tübingen, Alemanha
Eberhard Karls Universität Tübingen, Alemanha
Projetos

Projeto

Designação Financiadores
2023/02/01 - Atual NEURONS4 - New Edge in the therapeUtics of PaRkinsON´s diSeaSe from SeaweedS
2022.09196.PTDC
Investigador
Centro de Ciências do Mar e do Ambiente, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021 - Atual MARTICS- MARINE BIOACTIVE COMPOUNDS FOR THERAPEUTIC APPLICATIONS IN NEURODEGENERATIVE DISEASES
000
Orientador
Em curso
2021 - Atual Biotechnology and Pharmaceutical Medicine: Applications in prevalent diseases and therapeutic innovations
007
Investigador responsável
Universidade do Vale do Taquari, Brasil
Em curso
2017 - Atual Biotechnology and Pharmacology of Natural Products
-
Orientador
Universidade do Vale do Taquari, Brasil
2014 - Atual Milk production chain: use of biotechnologies to improve the quality of raw materials and use of dairy residues
007
Investigador
Universidade do Vale do Taquari, Brasil
2013 - Atual Redirection of drugs and small molecules and the development and validation of bioassays
006
Investigador responsável
Universidade do Vale do Taquari, Brasil
2012 - Atual Biotechnology in swine semen: proteomic approach and study of the addition of natural extracts
002
Investigador
Em curso
2019/02 - 2022/02 Biotics - Bioactive compounds and their association for new therapeutic applications
N/A
 Conselho Nacional de Desenvolvimento Científico e Tecnológico
2014 - 2019 Anti-inflammatory potential and in vivo / in vitro toxicity of native plant species from Vale do Taquari - RS
008
Investigador responsável
Universidade do Vale do Taquari, Brasil
Concluído
2011 - 2019 Bioprospecting for the sustainable use of wetlands (MT) - Evaluation of anti-ulcer activity of Calophyllum brasiliense and anti-inflammatory of Echinodorus Macrophyllus from Pantanal
00
Investigador
Concluído
2015 - 2018 Elaboration of fermented dairy products from isolated dairy bacteria in the region of Vale do Taquari
70/2014
Investigador responsável
Concluído
2013 - 2017 Anti-inflammatory, anticarcinogenic effect of plant extracts in cell culture
003
Investigador responsável
Universidade do Vale do Taquari, Brasil
2013 - 2016 Selection, identification and characterization of microorganisms for use in the manufacture of dairy products
005
Investigador
Universidade do Vale do Taquari, Brasil
Concluído
2012 - 2015 Chemical study and biological activity of native and adapted plants from Rio Grande do Sul
001
Investigador
Concluído
2012 - 2013 Chemical study and biological activity of native and adapted plants from Rio Grande do Sul
004
Investigador
Concluído
Produções

Publicações

Artigo em revista
  1. Hoffmann, L.F.; Martins, A.; Majolo, F.; Contini, V.; Laufer, S.; Goettert, M.I.. "Neural regeneration research model to be explored: SH-SY5Y human neuroblastoma cells". Neural Regeneration Research 18 6 (2023): 1265-1266. http://www.scopus.com/inward/record.url?eid=2-s2.0-85145185992&partnerID=MN8TOARS.
    10.4103/1673-5374.358621
  2. Mônica Cerutti Martellet; Fernanda Majolo; Rodrigo Gay Ducati; Claucia Fernanda Volken de Souza; Márcia Inês Goettert. "Probiotic applications associated with Psyllium fiber as prebiotics geared to a healthy intestinal microbiota: A review". Nutrition (2022): https://doi.org/10.1016/j.nut.2022.111772.
    10.1016/j.nut.2022.111772
  3. Alves, Celso; Silva, Joana; Afonso, Marta B.; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Pinteus, Susete; et al. Autor correspondente: Pedrosa, Rui. "Disclosing the antitumour potential of the marine bromoditerpene sphaerococcenol A on distinct cancer cellular models". Biomedicine & Pharmacotherapy 149 (2022): 112886. http://dx.doi.org/10.1016/j.biopha.2022.112886.
    Publicado • 10.1016/j.biopha.2022.112886
  4. Rehfeldt, Stephanie Cristine Hepp; Silva, Joana; Alves, Celso; Pinteus, Susete; Pedrosa, Rui; Laufer, Stefan; Goettert, Márcia Inês. "Neuroprotective Effect of Luteolin-7-O-Glucoside against 6-OHDA-Induced Damage in Undifferentiated and RA-Differentiated SH-SY5Y Cells". International Journal of Molecular Sciences 23 6 (2022): 2914. http://dx.doi.org/10.3390/ijms23062914.
    10.3390/ijms23062914
  5. Susano, Patrícia; Silva, Joana; Alves, Celso; Martins, Alice; Pinteus, Susete; Gaspar, Helena; Goettert, Márcia Ines; Pedrosa, Rui. "Mitigating the negative impacts of marine invasive species – Sargassum muticum - a key seaweed for skincare products development". Algal Research 62 (2022): 102634. http://dx.doi.org/10.1016/j.algal.2022.102634.
    10.1016/j.algal.2022.102634
  6. Marmitt, Diorge Jônatas; Bitencourt, Shanna; Coura, Chistiane Oliveira; Berger, Markus; Faleiro, Dalana; Kich, Débora Mara; Caye, Bruna; et al. "In vitro and in vivo anti-inflammatory and anticoagulant activities of Myrciaria plinioides D. Legrand ethanol leaf extract". Inflammopharmacology (2022): http://dx.doi.org/10.1007/s10787-022-00924-0.
    10.1007/s10787-022-00924-0
  7. Silva, J.; Alvariño, R.; Goettert, M.I.; Caruncho, H.J.; Alves, C.. "Editorial: Natural products as drivers in drug development for neurodegenerative disorders". Frontiers in Pharmacology 13 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85136263924&partnerID=MN8TOARS.
    10.3389/fphar.2022.932179
  8. Alves, C.; Silva, J.; Pintéus, S.; Guedes, R.A.; Guedes, R.C.; Alvariño, R.; Freitas, R.; et al. "Bromoditerpenes from the Red Seaweed Sphaerococcus coronopifolius as Potential Cytotoxic Agents and Proteasome Inhibitors and Related Mechanisms of Action". Marine Drugs 20 10 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85140595701&partnerID=MN8TOARS.
    10.3390/md20100652
  9. Kaufmann, G.; Klein, M.P.; Goettert, M.I.; Aguirre, T.A.S.. "Development and cytotoxicity evaluation of a cylindrical pH-responsive chitosan-genipin hydrogel for the oral delivery of diclofenac sodium". European Polymer Journal 181 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85140905701&partnerID=MN8TOARS.
    10.1016/j.eurpolymj.2022.111649
  10. Susano, P.; Silva, J.; Alves, C.; Martins, A.; Pinteus, S.; Gaspar, H.; Goettert, M.I.; Pedrosa, R.. "Saccorhiza polyschides—A Source of Natural Active Ingredients for Greener Skincare Formulations". Molecules 27 19 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139811737&partnerID=MN8TOARS.
    10.3390/molecules27196496
  11. Dörr, J.A.; Majolo, F.; Bortoluzzi, L.; de Vargas, E.Z.; Silva, J.; Pasini, M.; Stoll, S.N.; et al. "Antiulcerogenic Potential of the Ethanolic Extract of Ceiba speciosa (A. St.-Hil.) Ravenna Evaluated by In Vitro and In Vivo Studies". International Journal of Molecular Sciences 23 24 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85144703568&partnerID=MN8TOARS.
    10.3390/ijms232415634
  12. Diorge Jônatas Marmitt; Shanna Bitencourt; Gustavo Rodrigo da Silva; Claudete Rempel; Márcia Inês Goettert. "Traditional plants with antioxidant properties in clinical trials—A systematic review". Phytotherapy Research (2021): https://doi.org/10.1002/ptr.7202.
    10.1002/ptr.7202
  13. Fernanda Majolo; Guilherme Liberato da Silva; Lucas Vieira; Cetin Anli; Luís Fernando Saraiva Macedo Timmers; Stefan Laufer; Márcia Inês Goettert. "Neuropsychiatric Disorders and COVID-19: What We Know So Far". Pharmaceuticals 14 9 (2021): 933-933. https://doi.org/10.3390/ph14090933.
    10.3390/ph14090933
  14. Cláudia Monfroni Rocha; Alessandro Menna Alves; Beatriz Fabris Bettanin; Fernanda Majolo; Matthias Gehringer; Stefan Laufer; Márcia Inês Goettert. "Current jakinibs for the treatment of rheumatoid arthritis: a systematic review". Inflammopharmacology (2021): https://doi.org/10.1007/s10787-021-00822-x.
    10.1007/s10787-021-00822-x
  15. Diorge Jonatas Marmitt; Mohamad Hesam Shahrajabian; Márcia Inês Goettert; Claudete Rempel. "Clinical trials with plants in diabetes mellitus therapy: a systematic review". Expert Review of Clinical Pharmacology 14 6 (2021): 735-747. https://doi.org/10.1080/17512433.2021.1917380.
    10.1080/17512433.2021.1917380
  16. Joana Silva; Celso Alves; Susete Pinteus; Patrícia Susano; Marco Simões; Miguel Guedes; Alice Martins; et al. "Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: Neuroprotective and anti-inflammatory activities". Pharmacological Research 168 (2021): 105589-105589. https://doi.org/10.1016/j.phrs.2021.105589.
    10.1016/j.phrs.2021.105589
  17. Diorge Jônatas Marmitt; Márcia Inês Goettert; Claudete Rempel. "Compounds of plants with activity against SARS-CoV-2 targets". Expert Review of Clinical Pharmacology (2021): 1-11. https://doi.org/10.1080/17512433.2021.1903317.
    10.1080/17512433.2021.1903317
  18. Débora Bublitz Anton; Rodrigo Gay Ducati; Luís Fernando Saraiva Macedo Timmers; Stefan Laufer; Márcia Inês Goettert. "A Special View of What Was Almost Forgotten: p38d MAPK". Cancers (2021): https://doi.org/10.3390/cancers13092077.
    10.3390/cancers13092077
  19. Stephanie Cristine Hepp Rehfeldt; Stefan Laufer; Márcia Inês Goettert. "A Highly Selective In Vitro JNK3 Inhibitor, FMU200, Restores Mitochondrial Membrane Potential and Reduces Oxidative Stress and Apoptosis in SH-SY5Y Cells". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22073701.
    10.3390/ijms22073701
  20. Celso Alves; Joana Silva; Susete Pinteus; Eva Alonso; Rebeca Alvariño; Adriana Duarte; Diorge Marmitt; et al. "Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifolius". Molecules (2021): https://doi.org/10.3390/molecules26051374.
    10.3390/molecules26051374
  21. Fernanda Majolo; Guilherme Liberato da Silva; Lucas Vieira; Luís Fernando Saraiva Macedo Timmers; Stefan Laufer; Márcia Inês Goettert. "Review of Trials Currently Testing Stem Cells for Treatment of Respiratory Diseases: Facts Known to Date and Possible Applications to COVID-19". Stem Cell Reviews and Reports (2021): https://doi.org/10.1007/s12015-020-10033-6.
    10.1007/s12015-020-10033-6
  22. Silva, Joana; Alves, Celso; Martins, Alice; Susano, Patrícia; Simões, Marco; Guedes, Miguel; Rehfeldt, Stephanie; et al. "Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from Codium tomentosum". International Journal of Molecular Sciences 22 4 (2021): 1888. http://dx.doi.org/10.3390/ijms22041888.
    10.3390/ijms22041888
  23. Vincenzi, Angélica; Goettert, Márcia Inês; Volken de Souza, Claucia Fernanda. "An evaluation of the effects of probiotics on tumoral necrosis factor (TNF-a) signaling and gene expression". Cytokine & Growth Factor Reviews 57 (2021): 27-38. http://dx.doi.org/10.1016/j.cytogfr.2020.10.004.
    10.1016/j.cytogfr.2020.10.004
  24. Susano P; Silva J; Alves C; Martins A; Gaspar H; Pinteus S; Mouga T; et al. "Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata.". Marine drugs (2021): http://europepmc.org/abstract/med/33671016.
    10.3390/md19030135
  25. Timmers, L.F.S.M.; Peixoto, J.V.; Ducati, R.G.; Bachega, J.F.R.; de Mattos Pereira, L.; Caceres, R.A.; Majolo, F.; et al. "SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85107554045&partnerID=MN8TOARS.
    10.1038/s41598-021-91585-6
  26. Hepp Rehfeldt, Stephanie Cristine; Majolo, Fernanda; Goettert, Márcia Inês; Laufer, Stefan. "c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer’s Diseases". International Journal of Molecular Sciences 21 24 (2020): 9677. http://dx.doi.org/10.3390/ijms21249677.
    10.3390/ijms21249677
  27. Andreev, Stanislav; Pantsar, Tatu; El-Gokha, Ahmed; Ansideri, Francesco; Kudolo, Mark; Anton, Débora Bublitz; Sita, Giulia; et al. "Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3ß Inhibitors with Improved Metabolic Stability". International Journal of Molecular Sciences 21 21 (2020): 7823. http://dx.doi.org/10.3390/ijms21217823.
    10.3390/ijms21217823
  28. Haas, Isabel Cristina da Silva; Marmitt, Diorge Jônatas; Fedrigo, Isabela Maia Toaldo; Goettert, Márcia Inês; Bordignon-Luiz, Marilde T.. "Evaluation of antiproliferative and anti-inflammatory effects of non-pomace sediment of red grape juices (Vitis labrusca L.) in healthy and cancer cells after in vitro gastrointestinal simulation". PharmaNutrition 13 (2020): 100204. http://dx.doi.org/10.1016/j.phanu.2020.100204.
    10.1016/j.phanu.2020.100204
  29. Haas, Isabel Cristina da Silva; Marmitt, Diorge Jônatas; Fedrigo, Isabela Maia Toaldo; Goettert, Márcia Inês; Bordignon-Luiz, Marilde T.. "Evaluation of antiproliferative and anti-inflammatory effects of non-pomace sediment of red grape juices (Vitis labrusca L.) in healthy and cancer cells after in vitro gastrointestinal simulation". PharmaNutrition 13 (2020): 100204. http://dx.doi.org/10.1016/j.phanu.2020.100204.
    10.1016/j.phanu.2020.100204
  30. Marmitt, Diorge Jônatas; Bitencourt, Shanna; Silva, Gustavo Rodrigo da; Rempel, Claudete; Goettert, Márcia Inês. "RENISUS Plants and Their Potential Antitumor Effects in Clinical Trials and Registered Patents". Nutrition and Cancer (2020): 1-28. http://dx.doi.org/10.1080/01635581.2020.1810290.
    10.1080/01635581.2020.1810290
  31. Rama, Gabriela Rabaioli; Führ, Ana Júlia; da Silva, Jéssica Aparecida Bressan Soratto; Gennari, Adriano; Giroldi, Maiara; Goettert, Márcia Inês; Volken de Souza, Claucia Fernanda. "Encapsulation of Lactobacillus spp. using bovine and buffalo cheese whey and their application in orange juice". 3 Biotech 10 6 (2020): http://dx.doi.org/10.1007/s13205-020-02255-9.
    10.1007/s13205-020-02255-9
  32. Dullius, Anja; Fassina, Patricia; Giroldi, Maiara; Goettert, Márcia Inês; Volken de Souza, Claucia Fernanda. "A biotechnological approach for the production of branched chain amino acid containing bioactive peptides to improve human health: A review". Food Research International 131 (2020): 109002. http://dx.doi.org/10.1016/j.foodres.2020.109002.
    10.1016/j.foodres.2020.109002
  33. Majolo, F.; Biterncourt, Shana; Monteiro, B.; et al.,; Goettert, Márcia. "Antimicrobial and antileukemic effects: In vitro activity of Calyptranthes grandifolia aqueous leaf extract". Journal of Toxicology and Environmental Health Part A (2020):
    Aceite para publicação
  34. Majolo, F.; Bitencourt, S.; Wissmann Monteiro, B.; Viegas Haute, G.; Alves, C.; Silva, J.; Pinteus, S.; et al. "Antimicrobial and antileukemic effects: in vitro activity of Calyptranthes grandifolia aqueous leaf extract". Journal of Toxicology and Environmental Health - Part A: Current Issues (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85084355725&partnerID=MN8TOARS.
    10.1080/15287394.2020.1753606
  35. Diorge Jonatas Marmitt; Celso Alves; Joana Silva; Susete Pinteus; Taiane Schneider; Roberto Christ Vianna Santos; Elisete Maria de Freitas; et al. "Neuroprotective potential of Myrciaria plinioides D. Legrand extract in an in vitro human neuroblastoma model". Inflammopharmacology (2019): https://doi.org/10.1007/s10787-019-00652-y.
    10.1007/s10787-019-00652-y
  36. Majolo, Fernanda; Caye, Bruna; Stoll, Stefani; Leipelt, Juliano; Abujamra, Ana; Goettert, Márcia Inês. "The Prevention and Therapy of Prostate Cancer: An update on alternatives for treatment and future perspectives". Current Drug Therapy 14 (2019): http://dx.doi.org/10.2174/1574885514666190917150635.
    10.2174/1574885514666190917150635
  37. Anja Dullius; Claudia Monfroni Rocha; Stefan Laufer; Claucia Fernanda Volken de Souza; Márcia Inês Goettert. "Are peptides a solution for the treatment of hyperactivated JAK3 pathways?". Inflammopharmacology 27 3 (2019): 433-452. https://doi.org/10.1007/s10787-019-00589-2.
    10.1007/s10787-019-00589-2
  38. Fernanda Majolo; Luciana Knabben de Oliveira Becker Delwing; Diorge Jônatas Marmitt; Ivan Cunha Bustamante-Filho; Márcia Inês Goettert. "Medicinal plants and bioactive natural compounds for cancer treatment: Important advances for drug discovery". Phytochemistry Letters 31 (2019): 196-207. https://doi.org/10.1016%2Fj.phytol.2019.04.003.
    10.1016/j.phytol.2019.04.003
  39. Débora Mara Kich; Shanna Bitencourt; Dalana Faleiro; Sheila Mariele Immich; Diorge Jonatas Marmitt; Tamara Baldasso; Gabriela Viegas Haute; et al. "Adjunctive role of Calyptranthes tricona extract with probiotic Kluyveromyces marxianus on colorectal adenocarcinoma Caco-2 cells". Phytochemistry Letters 30 (2019): 1-5. https://doi.org/10.1016%2Fj.phytol.2019.01.001.
    10.1016/j.phytol.2019.01.001
  40. Stefani Stoll; Shanna Bitencourt; Stefan Laufer; Márcia Inês Goettert. "Myricetin inhibits panel of kinases implicated in tumorigenesis". Basic & Clinical Pharmacology & Toxicology 125 1 (2019): 3-7. https://doi.org/10.1111%2Fbcpt.13201.
    10.1111/bcpt.13201
  41. Fassina, Patricia; Quadros Nunes, Gabriela; Scherer Adami, Fernanda; Goettert, Marcia Ines; Volken de Souza, Claucia Fernanda. "Importance of Cheese Whey Processing: Supplements for Sports Activities – a Review". Polish Journal of Food and Nutrition Sciences 69 1 (2019): 89-99. http://dx.doi.org/10.31883/pjfns-2019-0008.
    Publicado • 10.31883/pjfns-2019-0008
  42. Goettert, Márcia. "Changes in IDH2, TET2 and KDM2B Gene Expression After Treatment With Classic Chemotherapeutic Agents and Decitabine in Myelogenous Leukemia Cell Lines". Journal of Hematology (2019): http://dx.doi.org/10.14740/jh531.
    10.14740/jh531
  43. Heider, F.; Pantsar, T.; Kudolo, M.; Ansideri, F.; De Simone, A.; Pruccoli, L.; Schneider, T.; et al. "Pyridinylimidazoles as GSK3ß Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks". ACS Medicinal Chemistry Letters 10 10 (2019): 1407-1414. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072980166&partnerID=MN8TOARS.
    10.1021/acsmedchemlett.9b00177
  44. Rosana Cavalleri; Júlia Sartori Becker; Aline Marjana Pavan; Paula Bianchetti; Márcia Inês Goettert; Eduardo Miranda Ethur; Ivan Cunha Bustamante-Filho. "Essential oils rich in monoterpenes are unsuitable as additives to boar semen extender". Andrologia 50 8 (2018): e13074-e13074. https://doi.org/10.1111/and.13074.
    10.1111/and.13074
  45. Marmitt DJ; Bitencourt S; Silva ADCE; Rempel C; Goettert MI. "The healing properties of medicinal plants used in the Brazilian public health system: a systematic review.". Journal of wound care (2018): http://europepmc.org/abstract/med/29883290.
    10.12968/jowc.2018.27.sup6.s4
  46. Dörr JA; Bitencourt S; Bortoluzzi L; Alves C; Silva J; Stoll S; Pinteus S; et al. "In vitro activities of Ceiba speciosa (A.St.-Hil) Ravenna aqueous stem bark extract.". Natural product research (2018): http://europepmc.org/abstract/med/29792358.
    10.1080/14786419.2018.1478823
  47. Dullius, Anja; Goettert, Márcia Inês; de Souza, Claucia Fernanda Volken. "Whey protein hydrolysates as a source of bioactive peptides for functional foods – Biotechnological facilitation of industrial scale-up". Journal of Functional Foods 42 (2018): 58-74. http://dx.doi.org/10.1016/j.jff.2017.12.063.
    10.1016/j.jff.2017.12.063
  48. Mallmann R; Ethur EM; Bianchetti P; Faleiro D; Hoehne L; Goettert MI. "Effectiveness of aqueous and hydroalcoholic extracts of Acanthospermum australe (Loefl.) Kuntze against diarrhea-inducing bacteria.". Brazilian journal of biology = Revista brasleira de biologia (2018): http://europepmc.org/abstract/med/29319752.
    10.1590/1519-6984.167376
  49. Goettert, Márcia; Jônatas, Diorge; Bitencourt, Shanna; Couto, Amanda; Rempel, Claudete. "Medicinal plants used in Brazil Public Health System with neuroprotective potential – A systematic review". Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 17 (2018): 84.
    Publicado
  50. Goettert, Márcia; Marmitt, D. J.; Bitencourt, S.; Silva A. D. C. E.; Rempel C.. "The healing properties of medicinal plants used in the Brazilian public health system: a systematic review". J Wound Care (2018): S4-S13.
    Publicado
  51. Marmitt, D.J.; Bitencourt, S.; Do Couto E Silva, A.; Rempel, C.; Goettert, M.I.. "Medicinal plants used in Brazil public health system with neuroprotective potential-A systematic review,Plantas medicinales utilizadas en el Sistema de Salud Pública de Brasil con potencial neuroprotector-Una revisión sistemática". Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 17 2 (2018): 84-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041484078&partnerID=MN8TOARS.
  52. Marmitt, D.J.; Bitencourt, S.; Do Couto E Silva, A.; Rempel, C.; Goettert, M.I.. "The healing properties of medicinal plants used in the Brazilian public health system: A systematic review". Journal of Wound Care 27 (2018): S4-S13. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048435562&partnerID=MN8TOARS.
    10.12968/jowc.2018.27.Sup6.S4
  53. D. Faleiro; S.M. Immich; F. Majolo; L. Mayer; E.M. Ethur; M.I. Goettert. "GC/MS analysis and potential cytotoxic activity of Calyptranthes grandifolia (O. Berg) , Calyptranthes tricona (D. Legrand) and Myrciaria plinioides (D. Legrand) essential oil in RAW264.7 and CHO-K1 cells". Biomedicine & Pharmacotherapy 89 (2017): 1431-1441. https://doi.org/10.1016%2Fj.biopha.2017.03.040.
    10.1016/j.biopha.2017.03.040
  54. Goettert, Márcia. "Anti-Cancer Phytometabolites Targeting Cancer Stem Cells.". Current genomics (2017): http://europepmc.org/articles/PMC5345336.
    10.2174/1389202917666160803162309
  55. Dexheimer GM; Becker Delving LKO; de Oliveira HS; Biolchi V; Goettert MI; Pozzobon A. "Calyptranthes grandifolia O.Berg (Myrtaceae) ethanolic extract inhibits TNF-a gene expression and cytokine release in vitro.". Molecular medicine reports (2017): http://europepmc.org/abstract/med/28447740.
    10.3892/mmr.2017.6319
  56. Goettert, Márcia. "Oficinas de Biotecnologia para o Ensino Médio: Antioxidantes, a Fonte da juventude?". Revista de Ensino de Bioquímica (2016): http://dx.doi.org/10.16923/reb.v14i3.648.
    10.16923/reb.v14i3.648
  57. Kich DM; Vincenzi A; Majolo F; Volken de Souza CF; Goettert MI. "Probiotic: effectiveness nutrition in cancer treatment and prevention.". Nutricion hospitalaria (2016): http://europepmc.org/abstract/med/28000477.
    10.20960/nh.806
  58. Débora Mara Kich; Shanna Bitencourt; Bruna Caye; Dalana Faleiro; Celso Alves; Joana Silva; Susete Pinteus; et al. "Lymphocyte genotoxicity and protective effect of Calyptranthes tricona (Myrtaceae) against H2O2-induced cell death in MCF-7 cells". Molecular and Cellular Biochemistry 424 1-2 (2016): 35-43. https://doi.org/10.1007%2Fs11010-016-2840-9.
    10.1007/s11010-016-2840-9
  59. Sulzbach DE Oliveira HS; Biolchi V; Richardt Medeiros HR; Bizerra Gandor Jantsch DB; Knabben DE Oliveira Becker Delving LK; Reckziegel R; Pozzobon A. "Effect of Helicobacter pylori on NFKB1, p38a and TNF-a mRNA expression levels in human gastric mucosa.". Experimental and therapeutic medicine (2016): http://europepmc.org/abstract/med/27284322.
    10.3892/etm.2016.3213
  60. Débora Mara Kich; Shanna Bitencourt; Celso Alves; Joana Silva; Susete Pinteus; Rui Pedrosa; Stefan Laufer; Claucia Fernanda Volken de Souza; Márcia Inês Goettert. "Neuromodulatory effects of Calyptranthes grandifolia extracts against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells". Biomedicine & Pharmacotherapy 84 (2016): 382-386. https://doi.org/10.1016%2Fj.biopha.2016.09.063.
    10.1016/j.biopha.2016.09.063
  61. Goettert, Márcia; Simonneti, E.; Eduardo, M. Ethur; et al.,. "Avaliação da atividade antimicrobiana de extratos de Eugenia anomala e Psidium salutare (Myrtaceae) frente à Escherichia coli e Listeria monocytogenes". Revista Brasileira de Plantas Medicinais 18 (2016): 9-12.
  62. Marmit, D; Bitencourt, Shanna; et al.,; Goettert, Márcia. "Scientific production of plant species included in the Brazilian national list of medicinal plants of interest to the unified health system (RENISUS) from 2010 to 2013". Journal of Chemical and Pharmaceutical Research 8 (2016): 123-132.
    Publicado
  63. Marmit, D.; Rempel, Claudete; et al.,; Goettert, Márcia. "Revisión sistemática de las plantas de interés para el Sistema de Salud con potencial terapéutico cardiovascular". Revista Cubana de Plantas Medicinales 21 (2016): 1-20.
    Publicado
  64. Diorge Jonatas Marmitt; Dalana Faleiro; Débora Mara Kich; Goettert, Márcia. "Oficinas de Biotecnologia para o Ensino Médio: Antioxidantes, a Fonte da juventude?". História da Ciência e Ensino: construindo interfaces 16 (2016): 46.
    Publicado
  65. Marmitt, D.J.; Rempel, C.; Goettert, M.I.; do Couto e Silva, A.; Fernández Pombo, C.N.. "Systematic review of the plants of interest to the national health system with cardiovascular therapeutic potential,Revisão sistemática das plantas de Interesse ao Sistema Único de Saúde com potencial terapêutico cardiovascular,Revisión sistemática de las plantas de interés para el Sistema de Salud con potencial terapéutico cardiovascular". Revista Cubana de Plantas Medicinales 21 1 (2016): 108-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-84966487004&partnerID=MN8TOARS.
  66. Marmitt, D.J.; Bitencourt, S.; e Silva, A.C.; Rempel, C.; Goettert, M.I.. "Scientific production of plant species included in the Brazilian national list of medicinal plants of interest to the unified health system (RENISUS) from 2010 to 2013". Journal of Chemical and Pharmaceutical Research 8 2 (2016): 123-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992297759&partnerID=MN8TOARS.
  67. Simonetti, E.; Ethur, M.E.; Castro, L.C.; Kauffmann, C.; Giacomin, A.C.; Ledur, A.; Arossi, K.; et al. "Evaluation of the antimicrobial activity of extracts of eugenia anomala and Psidium salutare (Myrtaceae) against the escherichia coli and listeria monocytogenes,Avaliação da atividade antimicrobiana de extratos de Eugenia anomala e Psidium salutare (Myrtaceae) frente à Escherichia coli e Listeria monocytogenes". Revista Brasileira de Plantas Medicinais 18 1 (2016): 9-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964414240&partnerID=MN8TOARS.
    10.1590/1983-084X/15_005
  68. Gabriela Viegas Haute; Eduardo Caberlon; Eamim Squizani; Fernanda Cristina de Mesquita; Leonardo Pedrazza; Bianca Andrade Martha; Denizar Alberto da Silva Melo; et al. "Gallic acid reduces the effect of LPS on apoptosis and inhibits the formation of neutrophil extracellular traps". Toxicology in Vitro 30 1 (2015): 309-317. https://doi.org/10.1016%2Fj.tiv.2015.10.005.
    10.1016/j.tiv.2015.10.005
  69. Baur B; Storch K; Martz KE; Goettert MI; Richters A; Rauh D; Laufer SA. "Metabolically stable dibenzo[b,e]oxepin-11(6H)-ones as highly selective p38 MAP kinase inhibitors: optimizing anti-cytokine activity in human whole blood.". Journal of medicinal chemistry (2013): http://europepmc.org/abstract/med/24131218.
    10.1021/jm401276h
  70. Selig R; Goettert M; Schattel V; Schollmeyer D; Albrecht W; Laufer S. "A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors.". Journal of medicinal chemistry (2012): http://europepmc.org/abstract/med/22951114.
    10.1021/jm300852w
  71. Martz KE; Dorn A; Baur B; Schattel V; Goettert MI; Mayer-Wrangowski SC; Rauh D; Laufer SA. "Targeting the hinge glycine flip and the activation loop: novel approach to potent p38a inhibitors.". Journal of medicinal chemistry (2012): http://europepmc.org/abstract/med/22897496.
    10.1021/jm300951u
  72. Goettert, Márcia. "Development of a p38d mitogen activated protein kinase ELISA assay for the quantitative determination of inhibitor activity.". Journal of pharmaceutical and biomedical analysis (2012): https://doi.org/10.1016/j.jpba.2012.03.008.
    10.1016/j.jpba.2012.03.008
  73. Martz, Kathrin; et al.,; Dorn, Angelika; Goettert, Márcia. "Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38a Inhibitors. Journal of Medicinal Chemistry". Journal of Medicinal Chemistry 55 (2012): 7862-7874.
    Publicado
  74. Selig, Roland; Goettert, Márcia; et al.,. "A Frozen Analogue Approach to Aminopyridinylimidazoles Leading to Novel and Promising p38 MAP Kinase Inhibitors". Journal of Medicinal Chemistry 55 (2012): 8429-8439.
    Publicado
  75. Goettert, Márcia. "Development of a p38d mitogen activated protein kinase ELISA assay for the quantitative determination of inhibitor activity". Journal of Pharmaceutical and Biomedical Analysis (Print) 66 (2012): 349-351.
    Publicado
  76. Goettert, Márcia. "Chiral sulfoxides as metabolites of 2-thioimidazole-based p38a mitogen-activated protein kinase inhibitors: enantioselective synthesis and biological evaluation.". Journal of medicinal chemistry (2011): https://doi.org/10.1021/jm101623p.
    10.1021/jm101623p
  77. Goettert M; Luik S; Graeser R; Laufer SA. "A direct ELISA assay for quantitative determination of the inhibitory potency of small molecules inhibitors for JNK3.". Journal of pharmaceutical and biomedical analysis (2011): http://europepmc.org/abstract/med/21316174.
    10.1016/j.jpba.2011.01.014
  78. Roland seling; Verena Schattel; et al.,; Goettert, Márcia. "Conformational effects on potency of thioimidazoles and dihydrothiazolines". MedChemComm 2 (2011): 261.
  79. Selig, R.; Schattel, V.; Goettert, M.; Schollmeyer, D.; Albrecht, W.; Laufer, S.. "Conformational effects on potency of thioimidazoles and dihydrothiazolines". MedChemComm 2 4 (2011): 261-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953882511&partnerID=MN8TOARS.
    10.1039/c0md00228c
  80. Goettert M; Schattel V; Koch P; Merfort I; Laufer S. "Biological evaluation and structural determinants of p38a mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.". Chembiochem : a European journal of chemical biology (2010): http://europepmc.org/abstract/med/21108268.
    10.1002/cbic.201000487
  81. Goettert, Márcia. "Catechin derivatives from Parapiptadenia rigida with in vitro wound-healing properties.". Journal of natural products (2010): https://doi.org/10.1021/np100523s.
    10.1021/np100523s
  82. Goettert M; Graeser R; Laufer SA. "Optimization of a nonradioactive immunosorbent assay for p38alpha mitogen-activated protein kinase activity.". Analytical biochemistry (2010): http://europepmc.org/abstract/med/20638357.
    10.1016/j.ab.2010.07.007
  83. Koch P; Jahns H; Schattel V; Goettert M; Laufer S. "Pyridinylquinoxalines and pyridinylpyridopyrazines as lead compounds for novel p38 alpha mitogen-activated protein kinase inhibitors.". Journal of medicinal chemistry (2010): http://europepmc.org/abstract/med/20078117.
    10.1021/jm901392x
  84. Schmidt C; Fronza M; Goettert M; Geller F; Luik S; Flores EM; Bittencourt CF; et al. "Biological studies on Brazilian plants used in wound healing.". Journal of ethnopharmacology (2009): http://europepmc.org/abstract/med/19429323.
    10.1016/j.jep.2009.01.022
Capítulo de livro
  1. Dullius, Anja; Rama, Gabriela Rabaioli; Giroldi, Maiara; Goettert, Márcia Inês; Lehn, Daniel Neutzling; Volken de Souza, Claucia Fernanda. "Bioactive peptide production in fermented foods". In Current Developments in Biotechnology and Bioengineering, 47-72. Elsevier, 2022.
    10.1016/b978-0-12-823506-5.00009-6
  2. Majolo, Fernanda; Martins, Alexandre; Rehfeldt, Stephanie; Henriques, João Antônio Pegas; Contini, Verônica; Goettert, Márcia Inês. "Approaches for the treatment of neurodegenerative diseases related to natural products". In Studies in Natural Products Chemistry, 1-63. Elsevier, 2021.
    10.1016/b978-0-12-819487-4.00014-8
  3. Martellet, Mônica Cerutti; Martins, Alexandre; Marmitt, Diorge Jonatas; Schneider, Taiane; Contini, Verônica; Goettert, Márcia Ines. "New opportunities for the application of natural products based on nitric oxide modulation: From research to registered patents". In Studies in Natural Products Chemistry, 1-40. Elsevier, 2020.
    10.1016/b978-0-12-817905-5.00001-9
Livro
  1. Goettert, Márcia; Heidrich, D; Viana, A; Mörschbächer, A. P.; Schlabitz, C; Pappen, E. Oficinas de biotecnologia para o ensino médio. 2021.
  2. Dullius, A.; Rama, G.R.; Giroldi, M.; Goettert, M.I.; Lehn, D.N.; Volken de Souza, C.F.. Bioactive peptide production in fermented foods. 2021.
  3. Majolo, F.; Martins, A.; Rehfeldt, S.; Henriques, J.A.P.; Contini, V.; Goettert, M.I.. Approaches for the treatment of neurodegenerative diseases related to natural products. 2021.
    10.1016/B978-0-12-819487-4.00014-8
  4. Hoehne, L.; et al.,; Goettert, Márcia. ANAIS DO I CONGRESSO DE BIOTECNOLOGIA DA REGIÃO SUL: CENÁRIO ATUAL E PERSPECTIVAS FUTURAS. UNIVATES. 2016.
    Publicado
  5. Dullius, M. M; Goettert, Márcia. Anais do XIV Salão de Iniciação Científica, Tecnológica e de Inovação. 2015.
    Publicado
  6. Goettert, Márcia. Anais do III Seminário Integrador de Iniciação Científica Tecnológica e Inovação. 2014.
    Publicado
  7. Goettert, Márcia. Anais da II Mostra de Trabalhos do Programa de Pós-graduação em Biotecnologia. 2014.
    Publicado
Poster em conferência
  1. Buhl, B.; Sheibel, T; et al.,; Goettert, Márcia. "Avaliação da atividade antimicrobiana do óleo essencial de Campomanesia aurea contra patógenos causadores de mastite bovina". Trabalho apresentado em Mostra de Trabalhos do curso de Farmácia, 2019. Anais da V e IV mostra de Trabalhos do curso de Farmácia, 2019.
  2. Grando, L. M.; Fassina, P.; et al.,; Goettert, Márcia. "Hidrólise enzimática do soro de queijo bubalino para obtenção de aminoácidos de cadeia ramificada.". Trabalho apresentado em III Congresso Internacional de Ciência, Tecnologia e Conhecimento, 2019.
  3. Santos L.; Bruna Caye; Schneider, T.; et al.,; Goettert, Márcia. "Efeito de anti-inflamatório inibidor de cox-2/ 5-lox associado a quimioterápico em células de adenocarcinoma de próstata". Trabalho apresentado em III Congresso Internacional de Ciência, Tecnologia e Conhecimento, 2019.
  4. Bruna Caye; Dalana Faleiro; et al.,; Goettert, Márcia. "ANTI-INFLAMMATORY PROPERTIES OF THE ETHANOLIC EXTRACT OF Myrciaria plinioides". Trabalho apresentado em Intenation Symposium: Natural Produts and Drug Discovery, 2014.
Pré-impressão
  1. Marmitt DJ; Bitencourt S; Coura CO; Berger M; Faleiro D; Kich DM; Caye B; et al. "In Vitro and in Vivo Anti-Inflammatory and Anticoagulant Activities of Myrciaria Plinioides D. Legrand Ethanol Leaf Extract". 2021. http://europepmc.org/abstract/PPR/PPR409450.
    10.21203/rs.3.rs-969373/v1
  2. Timmers L; Peixoto J; Ducati R; Bachega JF; Pereira LM; Caceres RA; Majolo F; et al. "SARS-CoV-2 Mutations in Brazil: From Genomics to Clinical Conditions". 2021. http://europepmc.org/abstract/PPR/PPR285808.
    10.26434/chemrxiv.14045783.v1
Tese / Dissertação
  1. "Development and optimization of in vitro kinase assays to screen extracts and isolated compounds from natural sources". 2010.

Propriedade Intelectual

Patente
  1. Goettert, Márcia; Silva, W. O. B. 2016. "Uso terapêutico de extratos de Ceiba speciosa".
    Concedida/Emitida
  2. Goettert, Márcia. 2016. "Uso terapêutico de extratos de Ceiba speciosa". Brasil.
    Permitida

Outros

Outra produção
  1. In Vitro and in Vivo Anti-Inflammatory and Anticoagulant Activities of Myrciaria Plinioides D. Legrand Ethanol Leaf Extract. 2021. Marmitt, D.J.; Bitencourt, S.; Coura, C.O.; Berger, M.; Faleiro, D.; Kich, D.M.; Caye, B.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85132059162&partnerID=MN8TOARS.
    10.21203/rs.3.rs-969373
  2. SARS-CoV-2 mutations in Brazil: From genomics to clinical conditions. 2021. Timmers, L.; Peixoto, J.; Ducati, R.; Bachega, J.F.; Pereira, L.M.; Caceres, R.A.; Majolo, F.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85103337675&partnerID=MN8TOARS.
    10.26434/chemrxiv.14045783
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023 - Atual New aproches in kinase molecules activity
Orientador
 Master in Biotechnology (Mestrado)
Universidade do Vale do Taquari, Brasil
2021 - Atual Investigation of small molecules for the treatment of neurodegenerative diseases
Orientador
 Biotechnology (Mestrado)
Universidade do Vale do Taquari, Brasil
2021 - Atual Investigation of small-molecule modulators of chronic inflammation associated with neurological damage from Covid-19
Orientador
 biotecnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2021 - Atual In vitro evaluation of ozone as an adjuvant in healing processes
Coorientador
 Master in Biotecnolohy (Mestrado)
Universidade do Vale do Taquari, Brasil
2021 - Atual Evaluation of melatonin levels and biomarkers of the inflammatory process in pregnant women with hypothyroidism
Coorientador
 Master in Medical Science (Mestrado)
Universidade do Vale do Taquari, Brasil
2020 - Atual Investigation of small molecules with anticancer potential
Orientador
 PhD in Biotechnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2020 - Atual Identification of molecular targets and proposition of molecules against SARS-CoV-2.
Orientador
 PhD in Biotecnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2020 - Atual Characterization and isolation of phytochemical compounds from the ethanolic extracts of the peel of Ceiba speciosa (A. ST-HILL) Ravenna and determination of antiinflammatory and antiulcerogenic activity in experimental models in vitro and in vivo
Orientador
 PhD in Biotechnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2020 - Atual Evaluation of the technological potential of chitosan spheres reticulated with genipin in oral drug delivery.
Coorientador
 Biosciences (Mestrado)
Universidade Federal de Ciências da Saúde de Porto Alegre, Brasil
2017 - Atual Metabolic effects induced by hydrolyzed proteins from bovine and buffalo cheese serums in wistar rats submitted to physical training on a treadmill
Orientador
 PhD in Biotechnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2021 - 2023 Association of natural products with biotechnological potential
Orientador
 PhD in Biotecnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2020 - 2021 Anti-inflammatory and antiulcerogenic potential of plant extract candidate to herbal medicine
Orientador
 Degree in Pharmacy (Licenciatura/Bacharelato)
Universidade do Vale do Taquari, Brasil
2020 - 2021 Development of a method for diagnosing breast cancer metastasis
Orientador
 Master in Biotecnology (Mestrado)
Universidade do Vale do Taquari, Brasil
2017 - 2021 Pharmacological potential of natural and synthetic products in neurodegenerative diseases
Orientador
 PhD in Biotechnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2017 - 2021 Association of natural products with biotechnological potential
Orientador
 PhD in Biotecnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2017 - 2021 Analysis of the neuroprotective potential of MAPK inhibitors in SH-SY5Y neuroblastoma cells
Orientador
 PhD in Biotechnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2017 - 2021 In silico prospection of bioactive peptides from cheese wheat with antibacterial and antitumor activities
Orientador
 PhD in Biotechnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2017 - 2021 ANALYSIS OF THE NEUROPROTECTIVE POTENTIAL OF MAPK INHIBITORS IN SH-SY5Y NEUROBLASTOMA CELLS
Orientador
 PhD in Biotecnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2019 - 2020 MAPK delta p38 inhibitors for the treatment of breast cancer
Orientador
 Master in Biotechnology (Mestrado)
Universidade do Vale do Taquari, Brasil
2019 - 2020 Investigation of a yeast's adhesion potential in CACO-2 colon adenocarcinoma cells
Orientador
 Degree in Dentistry (Licenciatura/Bacharelato)
Universidade do Vale do Taquari, Brasil
2019 - 2020 Hypericin inhibits viability and proliferation in hepatocarcinoma cells.
Orientador
 Master in Biotechnology (Mestrado)
Universidade do Vale do Taquari, Brasil
2019 - 2020 Investigation of the mechanisms of action of lactic acid bacteria with probiotic potential in activity anti-inflammatory
Coorientador
 Degree in Biotechnology (Mestrado)
Universidade do Vale do Taquari, Brasil
2019 - 2020 Identification of small molecules for the tratment of rheumatoid arthritis
Orientador
 Master in Biotecnology (Mestrado)
Universidade do Vale do Taquari, Brasil
2018 - 2020 MAPK delta p38 inhibitors for cancer treatment
Orientador
 Pos - Doc in Biotechnology (Outra)
Universidade do Vale do Taquari, Brasil
2016 - 2020 Evaluation of the healing potential of the ethanolic extract of leaves of Myrciaria plinioides D. Legrand., And analysis of preformulation based on gel for topical use
Orientador
 PhD in Biotechnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2016 - 2020 Production and application of bioactive peptides in health and food
Orientador
 PhD in Biotechnology (Doutoramento)
Universidade do Vale do Taquari, Brasil
2018 - 2019 Evaluation of JAK3 inhibitor in cell culture
Orientador
 Master in Biotechnology (Mestrado)
Universidade do Vale do Taquari, Brasil
2018 - 2019 Biotechnology and Pharmacology of Natural Products
Orientador
 Degree in dentistry (Licenciatura/Bacharelato)
Universidade do Vale do Taquari, Brasil
2018 - 2019 Investigation of the effect of lycofelone and its association with dexorubicin on LNCap prostate adenocarcinoma cells
Orientador
 Master in Biotechnology (Mestrado)
Universidade do Vale do Taquari, Brasil
2016 - 2018 Biotechnological potential of natural products in in vitro experimental models
Orientador
 Pos - Doc in Biotechnology (Outra)
Universidade do Vale do Taquari, Brasil
2012 - 2013 Use of ointment based on the sap of Croton lechleri as a help in the treatment of registered Suab/Lajeado -RS with diabetes and ulcers in lower Limbs
Orientador
 Master in Environment and Development (Mestrado)
Universidade do Vale do Taquari, Brasil
Distinções

Prémio

2019 Highlight award - The use of a herbal medicine associated with the encapsulation of microorganisms with probiotic potential in an in vitro experimental model. II International Congress of Science and Technology of Univates
2018 Third Best Work (Oral Category) Study of anti-inflammatory COX-2 and 5LOX inhibitors in Gastrointestinal cells. Hospital de Câncer de Barretos
2017 Honorable Mention - Antioxidant activity and cytotoxicity of extracts of species of the Melastomataceae family,Faculdade de Medicina de Ribeirão Preto
2017 Honor to merit - Academic quality and social relevance - Dissertation Stefani Stoll, I Brazilian Congress of Pharmaceutical Science
2014 Maria Marques Award - Showcase of Projects in Physiology -Increased expression of TNF-a in its relation to contamination by H. pylori in the human gastric mucosa, Department of Physiology at UFRGS and Physiology Group at UNIPAMPA