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I am currently an Assistant Professor at the University of Southern California (USC) in Los Angeles, USA, specializing in basic and translational research in vascular and neurobiology. Before this, I worked as an independent group leader and postdoctoral researcher at the Institute for Regenerative Medicine of the University of Zurich, Switzerland. I received my PhD at the ETH Zurich, Switzerland in 2019, defending a thesis entitled “Vascular Repair after Ischemia” supervised by Prof. Dr. M.E. Schwab. During my PhD, I became interested in translational stroke research and developing regenerative therapies in preclinical rodent models. From 2019, I joined the group of Prof. Dr. R.M. Nitsch and Dr. C. Tackenberg at the Institute for Regenerative Medicine (IREM) at the University of Zurich, Switzerland. From 2023, I work together with Prof. B. Zlokovic at the Zilkha Neurogenetic Institute at the University of Southern California, Los Angeles, USA. In my current role, my projects focus on developing next-generation stem cell-based therapies following stroke. I am currently a member of the Federation of European Neuroscience Society (FENS) and the Society for Neuroscience (SFN). I have received several fellowships and awards, including selection as a Young Scientist for the 70th Lindau Nobel Laureate Meeting 2020 by the Lindau Nobel committee and a full doctoral fellowship by the German Academic Scholarship Foundation, Germany's largest and most prestigious scholarship foundation.
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Identificação

Identificação pessoal

Nome completo
Ruslan Rust

Nomes de citação

  • Rust, Ruslan

Identificadores de autor

Ciência ID
4212-17D8-7E1C
ORCID iD
0000-0003-3376-3453
Formação
Grau Classificação
2016 - 2019
Concluído
 PhD Neuroscience (Doktor (PhD))
Especialização em Neuroscience
Eidgenössische Technische Hochschule Zürich Departement Gesundheitswissenschaften und Technologie, Suiça
2014 - 2016
Concluído
 RegBioMed (Master)
Zentrum für Regenerative Therapien Dresden, Alemanha
2011 - 2014
Concluído
 Molecular Biotechnology (Bachelor)
Especialização em Molecular Biotechnology
Universität Bielefeld Fakultät für Biologie, Alemanha
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/08 - Atual Investigador principal (carreira) (Investigação) University of Southern California, Estados Unidos
2021/10/01 - Atual Investigador principal (carreira) (Investigação) Universität Zürich Institut für Regenerative Medizin, Suiça
Projetos

Bolsa

Designação Financiadores
2023/09 - 2027/08 nextSTEPS: Next-Generation Stem Cell Therapy as an Emerging Paradigm for Stroke
216225
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
2021/04 - 2022/07 Brain shuttle for systemic delivery of iPS-derived neural cells in stroked mice
195902
 Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung
Produções

Publicações

Artigo em revista
  1. Satoshi Hosoki; Gurpreet K. Hansra; Tharusha Jayasena; Anne Poljak; Karen A. Mather; Vibeke S. Catts; Ruslan Rust; et al. "Molecular biomarkers for vascular cognitive impairment and dementia". Nature Reviews Neurology (2023): https://doi.org/10.1038/s41582-023-00884-1.
    10.1038/s41582-023-00884-1
  2. Rebecca J. Hood; Sonia Sanchez-Bezanilla; Daniel J. Beard; Ruslan Rust; Renée J. Turner; Shannon M. Stuckey; Lyndsey E. Collins-Praino; et al. "Leakage beyond the primary lesion: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke". Journal of Neurochemistry (2023): https://doi.org/10.1111/jnc.16008.
    10.1111/jnc.16008
  3. Ruslan Rust; Mea M Holm; Matteo Egger; Oliver Weinmann; Dani¿lle van Rossum; Fruzsina R Walter; Ana Raquel Santa-Maria; et al. "Nogo-A is secreted in extracellular vesicles, occurs in blood and can influence vascular permeability". Journal of Cerebral Blood Flow & Metabolism (2023): https://doi.org/10.1177/0271678X231216270.
    10.1177/0271678X231216270
  4. Ruslan Rust. "Rebooting disruptive science: Exploring the challenges and potential solutions". European Journal of Clinical Investigation (2023): https://doi.org/10.1111/eci.13988.
    10.1111/eci.13988
  5. Beatriz Achón Buil; Christian Tackenberg; Ruslan Rust. "Editing a gateway for cell therapy across the blood–brain barrier". Brain (2023): https://doi.org/10.1093/brain/awac393.
    10.1093/brain/awac393
  6. Weber RZ; Mulders G; Kaiser J; Tackenberg C; Rust R. "Deep learning-based behavioral profiling of rodent stroke recovery.". BMC biology (2022): http://europepmc.org/abstract/med/36243716.
    10.1186/s12915-022-01434-9
  7. Rust R; Weber RZ; Generali M; Kehl D; Bodenmann C; Uhr D; Wanner D; et al. "Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications.". Journal of translational medicine (2022): http://europepmc.org/abstract/med/36114512.
    10.1186/s12967-022-03610-5
  8. Rust R; Tackenberg C. "Stem Cell Therapy for Repair of the Injured Brain: Five Principles.". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry (2022): http://europepmc.org/abstract/med/35968796.
    10.1177/10738584221110100
  9. Achón Buil B; Rust R. "Preserving stroke penumbra by targeting lipid signalling.". Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2022): http://europepmc.org/abstract/med/35999812.
    10.1177/0271678x221121853
  10. Hofer AS; Scheuber MI; Sartori AM; Good N; Stalder SA; Hammer N; Fricke K; et al. "Stimulation of the cuneiform nucleus enables training and boosts recovery after spinal cord injury.". Brain : a journal of neurology (2022): http://europepmc.org/abstract/med/35583160.
    10.1093/brain/awac184
  11. de Leeuw SM; Kirschner AWT; Lindner K; Rust R; Budny V; Wolski WE; Gavin AC; Nitsch RM; Tackenberg C. "APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.". Stem cell reports (2022): http://europepmc.org/abstract/med/35545024.
    10.1016/j.stemcr.2022.03.018
  12. Weber RZ; Bodenmann C; Uhr D; Zürcher KJ; Wanner D; Generali M; Nitsch RM; Rust R; Tackenberg C. "Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain.". Journal of visualized experiments : JoVE (2022): http://europepmc.org/abstract/med/35156654.
    10.3791/63102
  13. Leiter O; Zhuo Z; Rust R; Wasielewska JM; Grönnert L; Kowal S; Overall RW; et al. "Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging.". Cell metabolism (2022): http://europepmc.org/abstract/med/35120590.
    10.1016/j.cmet.2022.01.005
  14. Rust R; Walker TL. "Isolation and Culture of Adult Hippocampal Precursor Cells as Free-Floating Neurospheres.". Methods in molecular biology (Clifton, N.J.) (2022): http://europepmc.org/abstract/med/34557999.
    10.1007/978-1-0716-1783-0_3
  15. de Leeuw SM; Kirschner AWT; Lindner K; Rust R; Budny V; Wolski WE; Gavin AC; Nitsch RM; Tackenberg C. "APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.". Stem cell reports (2021): http://europepmc.org/abstract/med/34919811.
    10.1016/j.stemcr.2021.11.007
  16. Rentsch NH; Rust R. "'Scary' pericytes: the fibrotic scar in brain and spinal cord lesions.". Trends in neurosciences (2021): http://europepmc.org/abstract/med/34774344.
    10.1016/j.tins.2021.10.013
  17. Sartori AM; Hofer AS; Scheuber MI; Rust R; Kessler TM; Schwab ME. "Slow development of bladder malfunction parallels spinal cord fiber sprouting and interneurons' loss after spinal cord transection.". Experimental neurology (2021): http://europepmc.org/abstract/med/34826427.
    10.1016/j.expneurol.2021.113937
  18. Weber RZ; Perron P; Rust R. "Astrocytes for brain repair: More than just a neuron's sidekick.". Brain pathology (Zurich, Switzerland) (2021): http://europepmc.org/abstract/med/34196052.
    10.1111/bpa.12999
  19. Kirabali T; Rust R. "iPS-derived pericytes for neurovascular regeneration.". European journal of clinical investigation (2021): http://europepmc.org/abstract/med/34050924.
    10.1111/eci.13601
  20. Rust R. "Towards blood biomarkers for stroke patients.". Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2021): http://europepmc.org/abstract/med/33563080.
    10.1177/0271678x21992664
  21. Weber RZ; Grönnert L; Mulders G; Maurer MA; Tackenberg C; Schwab ME; Rust R. "Characterization of the Blood Brain Barrier Disruption in the Photothrombotic Stroke Model.". Frontiers in physiology (2020): http://europepmc.org/abstract/med/33262704.
    10.3389/fphys.2020.586226
  22. Wasielewska JM; Grönnert L; Rund N; Donix L; Rust R; Sykes AM; Hoppe A; et al. "Author Correction: Mast cells increase adult neural precursor proliferation and differentiation but this potential is not realized in vivo under physiological conditions.". Scientific reports (2020): http://europepmc.org/abstract/med/33168937.
    10.1038/s41598-020-76589-y
  23. Kirabali T; Rust R; Rigotti S; Siccoli A; Nitsch RM; Kulic L. "Distinct changes in all major components of the neurovascular unit across different neuropathological stages of Alzheimer's disease.". Brain pathology (Zurich, Switzerland) (2020): http://europepmc.org/abstract/med/32866303.
    10.1111/bpa.12895
  24. "A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain". Frontiers in Neuroscience (2020): http://dx.doi.org/10.3389/fnins.2020.00244.
    10.3389/fnins.2020.00244
  25. Rust R. "Insights into the dual role of angiogenesis following stroke.". Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2020): http://europepmc.org/abstract/med/32065073.
    10.1177/0271678x20906815
  26. Rust R; Weber RZ; Grönnert L; Mulders G; Maurer MA; Hofer AS; Sartori AM; Schwab ME. "Anti-Nogo-A antibodies prevent vascular leakage and act as pro-angiogenic factors following stroke.". Scientific reports (2019): http://europepmc.org/abstract/med/31882970.
    10.1038/s41598-019-56634-1
  27. Rust R; Grönnert L; Weber RZ; Mulders G; Schwab ME. "Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair.". Trends in neurosciences (2019): http://europepmc.org/abstract/med/31285047.
    10.1016/j.tins.2019.05.006
  28. Rust R; Grönnert L; Gantner C; Enzler A; Mulders G; Weber RZ; Siewert A; et al. "Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke.". Proceedings of the National Academy of Sciences of the United States of America (2019): http://europepmc.org/abstract/med/31235580.
    10.1073/pnas.1905309116
  29. Rust R; Grönnert L; Dogançay B; Schwab ME. "A Revised View on Growth and Remodeling in the Retinal Vasculature.". Scientific reports (2019): http://europepmc.org/abstract/med/30824785.
    10.1038/s41598-019-40135-2
  30. Walker TL; Schallenberg S; Rund N; Grönnert L; Rust R; Kretschmer K; Kempermann G. "T Lymphocytes Contribute to the Control of Baseline Neural Precursor Cell Proliferation but Not the Exercise-Induced Up-Regulation of Adult Hippocampal Neurogenesis.". Frontiers in immunology (2018): http://europepmc.org/abstract/med/30619254.
    10.3389/fimmu.2018.02856
  31. Rust R; Grönnert L; Schwab ME. "Inflammation after Stroke: A Local Rather Than Systemic Response?". Trends in neurosciences (2018): http://europepmc.org/abstract/med/30327142.
    10.1016/j.tins.2018.09.011
  32. Rust R; Gantner C; Schwab ME. "Pro- and antiangiogenic therapies: current status and clinical implications.". FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2018): http://europepmc.org/abstract/med/30085886.
    10.1096/fj.201800640rr
  33. Berry S; Weinmann O; Fritz AK; Rust R; Wolfer D; Schwab ME; Gerber U; Ster J. "Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits.". PloS one (2018): http://europepmc.org/abstract/med/30040841.
    10.1371/journal.pone.0200896
  34. Rust R; Hofer AS; Schwab ME. "Stroke Promotes Systemic Endothelial Inflammation and Atherosclerosis.". Trends in molecular medicine (2018): http://europepmc.org/abstract/med/29747910.
    10.1016/j.molmed.2018.04.008
  35. "Mast cells increase adult neural precursor proliferation and differentiation but this potential is not realized in vivo under physiological conditions.". Scientific reports (2017): http://europepmc.org/abstract/med/29259265.
    10.1038/s41598-017-18184-2
  36. "Insights into the Dual Role of Inflammation after Spinal Cord Injury.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2017): http://europepmc.org/abstract/med/28469010.
    10.1523/jneurosci.0498-17.2017
Pré-impressão
  1. Rebecca J. Hood; Sonia Sanchez-Bezanilla; Daniel J. Beard; Ruslan Rust; Renée J. Turner; Shannon M. Stuckey; Lyndsey E. Collins-Praino; et al. "Leakage beyond the primary infarction: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke". 2023. https://doi.org/10.1101/2023.04.24.538047.
    10.1101/2023.04.24.538047
  2. Rebecca Z. Weber; Davide Bernardoni; Nora H. Rentsch; Beatriz Achón Buil; Stefanie Halliday; Mark-Aurel Augath; Daniel Razansky; Christian Tackenberg; Ruslan Rust. "Visualization and estimation of stroke infarct volumes in rodents". 2023. https://doi.org/10.1101/2023.07.14.547245.
    10.1101/2023.07.14.547245
  3. Ruslan Rust. "Stroke-related gene expression profiles across species: A meta-analysis". 2023. https://doi.org/10.1101/2023.03.13.532480.
    10.1101/2023.03.13.532480
  4. Weber RZ; Mulders G; Perron P; Tackenberg C; Rust R. "Molecular and anatomical roadmap of stroke pathology in immunodeficient mice". 2022. http://europepmc.org/abstract/PPR/PPR525985.
    10.1101/2022.07.28.501836
  5. Rust R; Weber RZ; Generali M; Kehl D; Bodenmann C; Uhr D; Wanner D; et al. "Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications". 2022. http://europepmc.org/abstract/PPR/PPR444597.
    10.1101/2022.01.18.476253
  6. Weber RZ; Mulders G; Kaiser J; Tackenberg C; Rust R. "Deep learning based behavioral profiling of rodent stroke recovery". 2021. http://europepmc.org/abstract/PPR/PPR381995.
    10.1101/2021.08.11.455647
  7. de Leeuw SM; Kirschner AWT; Lindner K; Rust R; Wolski WE; Gavin A; Nitsch RM; Tackenberg C. "APOE2, E3 and E4 differentially modulate cellular homeostasis, cholesterol metabolism and inflammatory response in isogenic iPSC-derived astrocytes". 2021. http://europepmc.org/abstract/PPR/PPR371523.
    10.1101/2021.07.17.452644