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Abel Martin Gonzalez Oliva studied Agronomy in Universidad de Buenos Aires/Argentine and moved to Germany where he completed a MSc (1986) and a Doktor (PhD) in Agrartechnik (agricultural technology) in1989 at the Universität Hohenheim. He moved to Portugal in 1989 and joined the Instituto de Tecnologia Química e Biológica/ Universidade Nova de Lisboa, initiating his activity has a researcher in the field of biosensors development. Since 2005 he lead the Biomolecular Diagnostic Laboratory. Today Abel Oliva has extensive expertise in the research areas of reconstructed human skin, namely in vitro 3D human skin and melanoma models. The group developed a skin-on-a-chip setup (epidermis and dermis) for long-term in vitro assays. During last years has been developing non-animal models for physiological assays, permeation and drug delivery tests. He has long experience with the development of biosensors for diagnosis and monitoring; fabrication of microdevices; design of microfluidic chips for cell sorting and cell characterization and the design and construction of organ-on-a-chip approaches (skin and vascular tissue). Abel Oliva has an h-Index of 17, published 61 papers in peer review journals and 7 book chapters. He participated/coordinated in 10 competitive projects during the last 10 years. He supervised 4 PhD students and has 2 PhD student undergoing; supervised 14 MSc thesis and has 3 MSc students undergoing their thesis; several training students of national and foreign visitor students (10 students EUREKA fellows from Borstel /Germany). He is member of the ITQB-NOVA Scientific Council, coordinator of the "Nano-processes for life sciences" curricular unit of the PhD programme MolBios of the ITQB-NOVA; since 2014 is coordinator of the post-graduation courses for laboratory training and since 2005 lecturer of Biosensors for several master coursers at the Faculdade de Ciencias/Universidade Nova de Lisboa.
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Identificação

Identificação pessoal

Nome completo
Abel Martin Gonzalez Oliva

Nomes de citação

  • Oliva, Abel
  • Gonzalez Oliva, Abel
  • Oliva, A.G.
  • Abel Martin Gonzalez Oliva

Identificadores de autor

Ciência ID
431C-8CE1-B7EE
ORCID iD
0000-0001-8320-0937
Researcher Id
B-9118-2011
Scopus Author Id
56254239700

Websites

Domínios de atuação

  • Ciências Agrárias - Biotecnologia Agrária e Alimentar - Biotecnologia Agrária e Biotecnologia Alimentar
  • Ciências da Engenharia e Tecnologias - Engenharia Médica
  • Ciências Naturais - Ciências Biológicas - Outras ciências biológicas

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Espanhol; Castelhano (Idioma materno)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Alemão Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2)
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
1986/06/01 - 1989/03/01
Concluído
 Agrartechnik (Doktor (PhD))
Especialização em landwirtschaft wissenschaft
Universität Hohenheim Fakultät Agrarwissenschaften, Alemanha
"Einfluss Verschiedener Parameter auf die Trenneigenschaften des Planetentrommel-sortierers bei der Korn-Spreu-Trennung" (TESE/DISSERTAÇÃO)
 cum laude
1984/09/01 - 1986/05/31
Concluído
 Agrartechnik (Master)
Especialização em Agrartechnik
Universität Hohenheim Fakultät Agrarwissenschaften, Alemanha
"Entwicklung eines Rechnergesteuerten Mesßystem zur Bestimmung des Druckprofiles an Mähdrescherreinigungsanlage" (TESE/DISSERTAÇÃO)
 Sehr gut
1977/03/01 - 1984/03/31
Concluído
 Engenharia agronómica (Licence)
Especialização em Producion agrícola
Universidad de Buenos Aires Facultad de Agronomía, Argentina
"Entwicklung eines Rechnergesteuerten Messystem zur Bestimung des Druckprofiles an Maehdrescherreinigungsanlage" (Development of a Measuring System to Determinate the Static Pressure Profile in the Cleaning System of Harvester Combines). Master Thesis. Ins" (TESE/DISSERTAÇÃO)
 bom
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1989/11/01 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Projetos

Projeto

Designação Financiadores
2021/10/01 - 2023/06/30 BioPinus Biotransformação de resina proveniente de pinus para a produção de biofixadores à base de compostos biotivos e pigmentos naturais com aplicação têxtil
LISBOA-01-0247- FEDER-072630
Investigador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/01/01 - 2022/12/31 Identify Mechanisms of Microvascular ENDOTHELIAL Dysfunction to Predict and Prevent Cardiovascular Diseases (CVD)
UIDP/04462/2020
Investigador
iNOVA4Health, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/01/01 - 2021/12/31 Developing novel modulators of skin pigmentation
UIDP/04462/2020
Investigador
iNOVA4Health, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018 - 2020 Mecanismos moleculares de internalização e processamento de melanina por queratinócitos
PTDC/BIA-CEL/29765/2017
Investigador
Universidade Nova de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/06/01 - 2019/05/31 Acoplamento de Fluídos Iónicos inspirados na Natureza e Sistemas Aquosos Bifásicos Microfluídicos para a Purificação de Anticorpos Monoclonais
PTDC/QEQ-FTT/3289/2014
Investigador
Universidade Nova de Lisboa, Portugal

BioResources 4 Sustainability, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015/03/01 - 2017/12/31 Development of a non-invasive method to measure blood glucose through the skin without need of calibration
201504-01-009
UID/Multi /04462/2013
Investigador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 iNOVA4Health
Concluído
2013/06 - 2015/05 Development of microfluidic platform for single cell studies
Provided by PTCRIS: 126191
126191
PTDC/BBB-IMG/1225/2012
PTDC/BBB-IMG/1225/2012
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Ministério da Ciência Tecnologia e Ensino Superior
2010/04/01 - 2014/09/30 PIROVAC Improvement of current and development of new vaccines for theileriosis and babesios of small ruminants
KBBE-3-245145-PIROVAC
Investigador
Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften, Alemanha
 European Commission
Concluído
2013/06/03 - 2014/06/02 InCell - Optical fiber tweezers for single cell manipulation and analysis
EXPL/BBB-IMG/0500/2012
Investigador
Instituto de Engenharia de Sistemas e Computadores Tecnologia e Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/03 - 2013/08 Hybrid electro-optical microfluidic device for single cell analysis
PTDC/SAU-BEB/102247/2008
Investigador responsável
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
 Ministério da Ciência Tecnologia e Ensino Superior
Concluído
2009/09 - 2012/03 Development of ultra-sensitive detection methods and plant nano-vaccines for the fungi Fusarium spp. using nanotechnological devices.
NANO/NTec-SQA/0131/2007
Investigador responsável
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2005/07/01 - 2009/04/30 Molecular characterization of Latin American and Mediterranean Babesia bovis and B. bigemina strains and its application for the development of improved control strategies
3691
Investigador
Universidad de Alcala de Henares, Espanha
 European Commission Sixth Framework Programme
Concluído
2005/07/01 - 2008/08/30 INCOME
515915
Investigador
Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften, Alemanha
 European Commission Seventh Framework Programme for Research and Technological Development International Cooperation
Concluído
2006/01/01 - 2007/12/31 Optical Fibre Sensors for Distributed Monitoring of Dissolved Oxygen and Temperature
POCI/AMB/56132/2004
Investigador
Instituto de Engenharia de Sistemas e Computadores, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. P C de Barros, Dragana; Reed, Patricia; Pinho, Mariana G.; Oliva, Abel. "Antimicrobial and Cytotoxic Effect of Nanostructured Lipid Carriers for Dermal Applications". Trabalho apresentado em 3rd International Biotechnology & Research Conference, on line conference, 2020.
    Publicado
  2. Rodrigues Ribeiro, R.S.; Queiros, R.B.; Ecoffet, C.; Soppera, O.; Oliva, A.; Guerreiro, A.; Jorge, P.A.S.. "Rapid fabrication of polymeric micro lenses for optical fiber trapping and beam shaping". 2014.
    10.1117/12.2060374
  3. Tillak, J.B.; Bernacka-Wojcik, I.; Barata, D.; Jorge, P.A.S.; Águas, H.; Oliva, A.G.. "Towards single cell spectroscopy and refractometry in microfluidic chip platforms". 2011.
    10.1117/12.892180
  4. Jorge, P.A.S.; Caldas, P.; Rosa, C.C.; Oliva, A.G.; Marques, M.B.; Santos, J.L.. "Optical temperature measurement configuration for fluorescence based oxygen sensors". 2004.
    10.1117/12.566591
Artigo em revista
  1. Hipólito, Ana; Xavier, Renato; Brito, Cheila; Tomás, Ana; Lemos, Isabel; Cabaço, Luís C.; Silva, Fernanda; et al. "BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 2 (2024): 166983. http://dx.doi.org/10.1016/j.bbadis.2023.166983.
    10.1016/j.bbadis.2023.166983
  2. Lopes, Joana; Ferreira-Gonçalves, Tânia; Ascensão, Lia; Viana, Ana S.; Carvalho, Lina; Catarino, José; Faísca, Pedro; et al. "Safety of Gold Nanoparticles: From In Vitro to In Vivo Testing Array Checklist". Pharmaceutics 15 4 (2023): 1120. http://dx.doi.org/10.3390/pharmaceutics15041120.
    10.3390/pharmaceutics15041120
  3. de Barros, Dragana P. C.; Santos, Rafaela; Reed, Patricia; Fonseca, Luís P.; Oliva, Abel. Autor correspondente: de Barros, Dragana P. C.. "Design of Quercetin-Loaded Natural Oil-Based Nanostructured Lipid Carriers for the Treatment of Bacterial Skin Infections". Molecules 27 24 (2022): 8818. http://dx.doi.org/10.3390/molecules27248818.
    Acesso aberto • Publicado • 10.3390/molecules27248818
  4. Hall, Michael J; Lopes-Ventura, Sara; Matilde Neto; Charneca, João; Zoio, Patrícia; Miguel C. Seabra; Abel Martin Gonzalez Oliva; Barral, Duarte C.. Autor correspondente: Hall, Michael J. "Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer". bioRxiv (2022): https://www.biorxiv.org/content/10.1101/2022.03.03.482849v1.
    Em revisão
  5. Zoio, Patrícia; Oliva, Abel. "Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models". Pharmaceutics 14 3 (2022): 682. http://dx.doi.org/10.3390/pharmaceutics14030682.
    10.3390/pharmaceutics14030682
  6. Zoio, Patrícia; Lopes-Ventura, Sara; Marto, Joana; Gonzalez Oliva, Abel. Autor correspondente: Gonzalez Oliva, Abel. "Open-source human skin model with an in vivo-like barrier for drug testing". ALTEX 33 3 (2022): 3-16. http://dx.doi.org/10.14573/altex.2111182.
    Acesso aberto • Publicado • 10.14573/altex.2111182
  7. Zoio, Patrícia; Lopes-Ventura, Sara; Abel Martin Gonzalez Oliva. "Biomimetic full-thickness skin-on-a-chip based on a fibroblast-derived matrix". MICRO (2022): https://susy.mdpi.com/user/manuscripts/review_info/1e6a03960ee2dd0a44017658151ff296.
    Acesso aberto • Aceite para publicação
  8. Pfluck, Ana C. D.; de Barros, Dragana P. C.; Oliva, Abel; Fonseca, Luis P.. "Enzymatic Poly(octamethylene suberate) Synthesis by a Two-Step Polymerization Method Based on the New Greener Polymer-5B Technology". Processes 10 2 (2022): 221. http://dx.doi.org/10.3390/pr10020221.
    10.3390/pr10020221
  9. Murtinheira, Fernanda; Migueis, Mafalda; Letra-Vilela, Ricardo; Diallo, Mickael; Quezada, Andrea; Valente, Cláudia A.; Oliva, Abel; et al. "Sacsin Deletion Induces Aggregation of Glial Intermediate Filaments". Cells 11 2 (2022): 299. http://dx.doi.org/10.3390/cells11020299.
    Publicado • 10.3390/cells11020299
  10. Zoio, Patrícia. "Open-source human skin model with an in vivo-like barrier for drug testing". ALTEX (2022): http://dx.doi.org/10.14573/altex.2111182.
    10.14573/altex.2111182
  11. de Barros, Dragana P. C.; Reed, Patricia; Alves, Marta; Santos, Rafaela; Oliva, Abel. "Biocompatibility and Antimicrobial Activity of Nanostructured Lipid Carriers for Topical Applications Are Affected by Type of Oils Used in Their Composition". Pharmaceutics 13 11 (2021): 1950. http://dx.doi.org/10.3390/pharmaceutics13111950.
    Publicado • 10.3390/pharmaceutics13111950
  12. Esmail, Asiyah; Pereira, João R.; Sevrin, Chantal; Grandfils, Christian; Menda, Ugur Deneb; Fortunato, Elvira; Oliva, Abel; Freitas, Filomena. "Preparation and Characterization of Porous Scaffolds Based on Poly(3-hydroxybutyrate) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)". Life 11 9 (2021): 935. http://dx.doi.org/10.3390/life11090935.
    10.3390/life11090935
  13. Zoio, Patrícia; Lopes-Ventura, Sara; Oliva, Abel. "Barrier-on-a-Chip with a Modular Architecture and Integrated Sensors for Real-Time Measurement of Biological Barrier Function". Micromachines 12 7 (2021): 816. http://dx.doi.org/10.3390/mi12070816.
    10.3390/mi12070816
  14. Costa, Júlia; Gromicho, Marta; Pronto-Laborinho, Ana; Almeida, Conceição; Gomes, Ricardo A.; Guerreiro, Ana C. L.; Oliva, Abel; Pinto, Susana; de Carvalho, Mamede. "Cerebrospinal Fluid Chitinases as Biomarkers for Amyotrophic Lateral Sclerosis". Diagnostics 11 7 (2021): 1210. http://dx.doi.org/10.3390/diagnostics11071210.
    10.3390/diagnostics11071210
  15. Zoio, Patrícia; Ventura, Sara; Leite, Mafalda; Oliva, Abel. "Pigmented Full-Thickness Human Skin Model Based on a Fibroblast-Derived Matrix for Long-Term Studies". Tissue Engineering Part C: Methods 27 7 (2021): 433-443. http://dx.doi.org/10.1089/ten.tec.2021.0069.
    10.1089/ten.tec.2021.0069
  16. Esmail, Asiyah; Pereira, João R.; Zoio, Patrícia; Silvestre, Sara; Menda, Ugur Deneb; Sevrin, Chantal; Grandfils, Christian; et al. "Oxygen Plasma Treated-Electrospun Polyhydroxyalkanoate Scaffolds for Hydrophilicity Improvement and Cell Adhesion". Polymers 13 7 (2021): 1056. http://dx.doi.org/10.3390/polym13071056.
    10.3390/polym13071056
  17. Pinto, Fátima; Fonseca, Luis P.; Souza, Sofia; Oliva, Abel; de Barros, Dragana P.C.. "Topical distribution and efficiency of nanostructured lipid carriers on a 3D reconstructed human epidermis model". Journal of Drug Delivery Science and Technology 57 (2020): 101616. http://dx.doi.org/10.1016/j.jddst.2020.101616.
    10.1016/j.jddst.2020.101616
  18. S. L. Souza; G. Graça; A. Oliva. "Characterization of sweat induced with pilocarpine, physical exercise, and collected passively by metabolomic analysis". Skin Research and Technology (2018): https://doi.org/10.1111/srt.12412.
    10.1111/srt.12412
  19. Oliva, Abel. "Editorial for Special Issue: Advances in Microfluidic Devices for Cell Handling and Analysis". Micromachines (2017): http://www.mdpi.com/2072-666X/8/6/184.
    10.3390/mi8060184
  20. Gonçalves, M.; De Carvalho, M.; Peixoto, C.; Alves, P.; Barreto, C.; Oliva, A.; Pinto, S.; et al. "Phosphoneurofilament heavy chain and vascular endothelial growth factor as cerebrospinal fluid biomarkers for ALS". Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 18 1-2 (2017): 134-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-84981485527&partnerID=MN8TOARS.
    10.1080/21678421.2016.1212894
  21. Pereira, F.M.; Bernacka-Wojcik, I.; Ribeiro, R.S.R.; Lobato, M.T.; Fortunato, E.; Martins, R.; Igreja, R.; et al. "Hybrid microfluidic platform for multifactorial analysis based on electrical impedance, refractometry, optical absorption and fluorescence". Micromachines 7 10 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84994806266&partnerID=MN8TOARS.
    10.3390/mi7100181
  22. Oliva, Abel. "Characterization of a papain-like cysteine protease essential for the survival of Babesia ovis merozoites". Ticks and Tick-borne Diseases (2015): http://www.sciencedirect.com/science/article/pii/S1877959X1530008X.
    10.1016/j.ttbdis.2015.09.002
  23. Ribeiro, R.S.R.; Soppera, O.; Oliva, A.G.; Guerreiro, A.; Jorge, P.A.S.. "New Trends on Optical Fiber Tweezers". Journal of Lightwave Technology 33 16 (2015): 3394-3405. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938376204&partnerID=MN8TOARS.
    10.1109/JLT.2015.2448119
  24. Oliva, Abel. "Highly sensitive method for diagnostic of subclinical Babesia ovis infection". Ticks and Tick-borne Diseases (2014):
    10.1016/j.ttbdis.2014.07.005
  25. Oliva, Abel. "Quantum dots and superparamagnetic nanoparticles interaction with pathogenic fungi: internalization and toxicity profile". ACS Appl. Mater. Interfaces (2014):
    10.1021/am501029g
  26. György, E.; Pérez del Pino, A.; Roqueta, J.; Sánchez, C.; Oliva, A.G.. "Processing and immobilization of chondroitin-4-sulphate by UV laser radiation". Colloids and Surfaces B: Biointerfaces 104 (2013): 169-173. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872233389&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2012.11.044
  27. Santos, A.R.; Miguel, A.S.; Macovei, A.; Maycock, C.; Balestrazzi, A.; Oliva, A.; Fevereiro, P.. "CdSe/ZnS Quantum Dots trigger DNA repair and antioxidant enzyme systems in Medicago sativa cells in suspension culture". BMC Biotechnology 13 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84890470926&partnerID=MN8TOARS.
    10.1186/1472-6750-13-111
  28. Renneker, S.; Abdo, J.; Salih, D.E.A.; Karagenç, T.; Bilgiç, H.; Torina, A.; Oliva, A.G.; et al. "Can Anaplasma ovis in Small Ruminants be Neglected any Longer?". Transboundary and Emerging Diseases 60 SUPPL.2 (2013): 105-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887343940&partnerID=MN8TOARS.
    10.1111/tbed.12149
  29. György, E.; Pérez Del Pino, A.; Roqueta, J.; Ballesteros, B.; Miguel, A.S.; Maycock, C.; Oliva, A.G.. "Synthesis and characterization of CdSe/ZnS core-shell quantum dots immobilized on solid substrates through laser irradiation". Physica Status Solidi (A) Applications and Materials Science 209 11 (2012): 2201-2207. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869790023&partnerID=MN8TOARS.
    10.1002/pssa.201127749
  30. Gordo, J.; Máximo, P.; Cabrita, E.; Lourenço, A.; Oliva, A.; Almeida, J.; Filipe, M.; et al. "Thymus mastichina: Chemical constituents and their anti-cancer activity". Natural Product Communications 7 11 (2012): 1491-1494. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869784814&partnerID=MN8TOARS.
  31. György, E.; Pino, A.P.D.; Roqueta, J.; Ballesteros, B.; Miguel, A.S.; Maycock, C.D.; Oliva, A.G.. "Synthesis and laser immobilization onto solid substrates of CdSe/ZnS core-shell quantum dots". Journal of Physical Chemistry C 115 31 (2011): 15210-15216. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961231496&partnerID=MN8TOARS.
    10.1021/jp203051b
  32. Campos, E.; Moura, T.F.; Oliva, A.; Leandro, P.; Soveral, G.. "Lack of Aquaporin 3 in bovine erythrocyte membranes correlates with low glycerol permeation". Biochemical and Biophysical Research Communications 408 3 (2011): 477-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955766444&partnerID=MN8TOARS.
    10.1016/j.bbrc.2011.04.057
  33. Silva, M. G.; Ueti, M. W.; Norimine, J.; Florin-Christensen, M.; Bastos, R. G.; Goff, W. L.; Brown, W. C.; Oliva, A.; Suarez, C. E.. "Babesia bovis expresses Bbo-6cys-E, a member of a novel gene family that is homologous to the 6-cys family of Plasmodium". Parasitology International 60 1 (2011): 13-18.
    10.1016/j.parint.2010.09.004
  34. Santos, A.R.; Miguel, A.S.; Tomaz, L.; Malhó, R.; Maycock, C.; Vaz Patto, M.C.; Fevereiro, P.; Oliva, A.. "The impact of CdSe/ZnS Quantum Dots in cells of Medicago sativa in suspension culture". Journal of Nanobiotechnology 8 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77957367727&partnerID=MN8TOARS.
    10.1186/1477-3155-8-24
  35. Silva, M.G.; Marques, P.X.; Oliva, A.. "Detection of Babesia and Theileria species infection in cattle from Portugal using a reverse line blotting method". Veterinary Parasitology 174 3-4 (2010): 199-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649322620&partnerID=MN8TOARS.
    10.1016/j.vetpar.2010.08.038
  36. Silva, M.G.; Ueti, M.W.; Norimine, J.; Florin-Christensen, M.; Bastos, R.G.; Goff, W.L.; Brown, W.C.; Oliva, A.; Suarez, C.E.. "Babesia bovis expresses a neutralization-sensitive antigen that contains a microneme adhesive repeat (MAR) domain". Parasitology International 59 2 (2010): 294-297. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951652955&partnerID=MN8TOARS.
    10.1016/j.parint.2010.03.004
  37. Silva, M.G.; Henriques, G.; Sánchez, C.; Marques, P.X.; Suarez, C.E.; Oliva, A.. "First survey for Babesia bovis and Babesia bigemina infection in cattle from Central and Southern regions of Portugal using serological and DNA detection methods". Veterinary Parasitology 166 1-2 (2009): 66-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350349014&partnerID=MN8TOARS.
    10.1016/j.vetpar.2009.07.031
  38. Sánchez, C.; Campos, E.; Oliva, A.G.. "Babesia bovis: Effect of Albumax II and orotic acid in a low-serum in vitro culture". Experimental Parasitology 121 3 (2009): 274-278. http://www.scopus.com/inward/record.url?eid=2-s2.0-59849112521&partnerID=MN8TOARS.
    10.1016/j.exppara.2008.11.017
  39. Criado-Fornelio, A; Buling, A; Asenzo, G; Benitez, D; Florin-Christensen, M; Gonzalez-Oliva, A; Henriques, G; et al. "Development of fluorogenic probe-based PCR assays for the detection and quantification of bovine piroplasmids". Veterinary Parasitology 162 3-4 (2009): 200-206.
    10.1016/j.vetpar.2009.03.040
  40. Nascimento, E.M.; Nogueira, N.; Silva, T.; Braschler, T.; Demierre, N.; Renaud, P.; Oliva, A.G.. "Dielectrophoretic sorting on a microfabricated flow cytometer: Label free separation of Babesia bovis infected erythrocytes". Bioelectrochemistry 73 2 (2008): 123-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-48949087848&partnerID=MN8TOARS.
    10.1016/j.bioelechem.2008.04.018
  41. Braschler, T.; Demierre, N.; Nascimento, E.; Silva, T.; Oliva, A.G.; Renaud, P.. "Continuous separation of cells by balanced dielectrophoretic forces at multiple frequencies". Lab on a Chip - Miniaturisation for Chemistry and Biology 8 2 (2008): 280-286. http://www.scopus.com/inward/record.url?eid=2-s2.0-38849092068&partnerID=MN8TOARS.
    10.1039/b710303d
  42. Ahmed, J.S.; Oliva, A.G.; Seitzer, U.. "Animal health: harmonisation and distribution of pathogen detection and differentiation tools". Transboundary and Emerging Diseases 55 5-6 (2008): 187-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-51049096575&partnerID=MN8TOARS.
    10.1111/j.1865-1682.2008.01038.x
  43. Silva, M.G.; Helali, S.; Esseghaier, C.; Suarez, C.E.; Oliva, A.; Abdelghani, A.. "An impedance spectroscopy method for the detection and evaluation of Babesia bovis antibodies in cattle". Sensors and Actuators, B: Chemical 135 1 (2008): 206-213. http://www.scopus.com/inward/record.url?eid=2-s2.0-56249083518&partnerID=MN8TOARS.
    10.1016/j.snb.2008.08.019
  44. Küttel, C.; Nascimento, E.; Demierre, N.; Silva, T.; Braschler, T.; Renaud, P.; Oliva, A.G.. "Label-free detection of Babesia bovis infected red blood cells using impedance spectroscopy on a microfabricated flow cytometer". Acta Tropica 102 1 (2007): 63-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249307247&partnerID=MN8TOARS.
    10.1016/j.actatropica.2007.03.002
  45. Nascimento, E.; Silva, T.; Oliva, A.. "Identification, characterization and manipulation of Babesia-bovis-infected red blood cells using microfluidics technology.". Parassitologia 49 Suppl 1 (2007): 45-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-38449108989&partnerID=MN8TOARS.
  46. Silvestre, Ó.F.; Silva, M.G.; Oliva, A.G.; Cruz, H.J.. "Spherical vs. granular immobilization support selection and performance on an optical flow cell immunosensor based on the fluorescence of cyanine 5". Preparative Biochemistry and Biotechnology 36 4 (2006): 333-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748710417&partnerID=MN8TOARS.
    10.1080/10826060600912617
  47. Miranda, J.P.G.; Nascimento, E.M.; Cruz, H.J.; Yin, H.; Zweygarth, E.; Oliva, A.G.. "Establishment of optimal conditions for long-term culture of erythrocytic stages of Theileria uilenbergi". American Journal of Veterinary Research 67 11 (2006): 1908-1913. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751236751&partnerID=MN8TOARS.
    10.2460/ajvr.67.11.1908
  48. Miranda, J.; Bakheit, M. A.; Liu, Z.; Yin, H.; Mu, Y.; Guo, S.; Beyer, D.; et al. "Development of a recombinant indirect ELISA for the diagnosis of Theileria sp (China) infection in small ruminants". Parasitology Research 98 6 (2006): 561-567.
    10.1007/s00436-005-0105-8
  49. Jorge, P.A.S.; Caldas, P.; Da Silva, J.C.G.E.; Rosa, C.C.; Oliva, A.G.; Santos, J.L.; Farahi, F.. "Luminescence-based optical fiber chemical sensors". Fiber and Integrated Optics 24 3-4 (2005): 201-225. http://www.scopus.com/inward/record.url?eid=2-s2.0-18144402429&partnerID=MN8TOARS.
    10.1080/01468030590922731
  50. Jorge, P.A.S.; Caldas, P.; Rosa, C.C.; Oliva, A.G.; Santos, J.L.. "Optical fiber probes for fluorescence based oxygen sensing". Sensors and Actuators, B: Chemical 103 1-2 (2004): 290-299. http://www.scopus.com/inward/record.url?eid=2-s2.0-14744287900&partnerID=MN8TOARS.
    10.1016/j.snb.2004.04.086
  51. Silva, M.; Cruz, H.; Rossetti, O.; Arese, A.; Oliva, A.. "Development of an optical immunosensor based on the fluorescence of Cyanine-5 for veterinarian diagnostics.". Biotechnology letters 26 12 (2004): 993-997. http://www.scopus.com/inward/record.url?eid=2-s2.0-16644370365&partnerID=MN8TOARS.
  52. Rosa, C.C.; Cruz, H.J.; Vidal, M.; Oliva, A.G.. "Optical biosensor based on nitrite reductase immobilised in controlled pore glass". Biosensors and Bioelectronics 17 1-2 (2002): 45-52. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036134830&partnerID=MN8TOARS.
    10.1016/S0956-5663(01)00263-9
  53. Cruz, H.J.; Rosa, C.C.; Oliva, A.G.. "Immunosensors for diagnostic applications". Parasitology Research 88 SUPPL. 1 (2002): http://www.scopus.com/inward/record.url?eid=2-s2.0-0036315450&partnerID=MN8TOARS.
    10.1007/s00436-001-0559-2
  54. Ferretti, S.; Lee, S.-K.; MacCraith, B.D.; Oliva, A.G.; Richardson, D.J.; Russell, D.A.; Sapsford, K.E.; Vidal, M.. "Optical biosensing of nitrite ions using cytochrome cd1 nitrite reductase encapsulated in a sol-gel matrix". Analyst 125 11 (2000): 1993-1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033710333&partnerID=MN8TOARS.
    10.1039/b006621o
  55. Vidal, M.; Prata, M.; Santos, S.; Tavares, T.; Hossfeld, J.; Preininger, C.; Oliva, A.. "Fluorescence IgG immunosensor based on a micro flow cell containing controlled pore glass as immobilisation support". Analyst 125 8 (2000): 1387-1391. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033839747&partnerID=MN8TOARS.
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  56. Vidal, M.I.; Stiene, M.; Henkel, J.; Bilitewski, U.; Costa, J.V.; Oliva, A.G.. "A solid-phase enzyme linked immunosorbent assay using monoclonal antibodies, for the detection of african swine fever virus antigens and antibodies". Journal of Virological Methods 66 2 (1997): 211-218. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030849669&partnerID=MN8TOARS.
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Capítulo de livro
  1. Águas, Hugo; Fortunato, Elvira; Igreja, Rui; Martins, Rodrigo; Abel Martin Gonzalez Oliva. Autor correspondente: Fortunato, Elvira. "Biosensors and diagnostic tests". In From Life Molecules to Global Health, 145-163. Lisboa, Portugal: PRINCIPIA, 2021.
    Publicado
Livro
  1. Miguel, A.S.; Maycock, C.; Oliva, A.. Synthesis and functionalization of CdSe/ZnS QDs using the successive ion layer adsorption reaction and mercaptopropionic acid phase transfer methods. 2012.
    10.1007/978-1-61779-953-2_10
  2. Santos, A.R.; Miguel, A.S.; Fevereiro, P.; Oliva, A.. Evaluation of cytotoxicity of 3-mercaptopropionic acid-modified quantum dots on medicago sativa cells and tissues. 2012.
    10.1007/978-1-61779-953-2_36
  3. Palmeira, J.; Lopes, L.; Silva, A.J.; Jorge, P.A.S.; Oliva, A.. Optimization of ormosil glasses for luminescence based dissolved oxygen sensors. 2010.
    10.4028/www.scientific.net/SSP.161.1
  4. Miranda, J.P.G.; Bakheit, M.; Schneider, I.; Haller, D.; Ahmed, J.S.; Yin, H.; Oliva, A.G.; Seitzer, U.. Identification of homologous genes of T. annulata proteins in the genome of Theileria sp. (China). 2006.
    10.1196/annals.1373.067
  5. Miranda, J.; Nascimento, E.; Cruz, H.; Hong, Y.; Coelho, A.; Ahmed, J.S.; Oliva, A.G.. Identification and characterization of merozoite antigens of a Theileria species highly pathogenic for small ruminants in China. 2006.
    10.1196/annals.1373.063
  6. Silva, M.; Wilkowsky, S.; De Echaide, S.T.; Farber, M.; Oliva, A.. Development of an immunosensor for the diagnosis of bovine anaplasmosis. 2006.
    10.1196/annals.1373.056
  7. Miranda, J.; Stumme, B.; Beyer, D.; Cruz, H.; Oliva, A.G.; Bakheit, M.; Wicklein, D.; et al. Identification of antigenic proteins of a Theileria species pathogenic for small ruminants in China recognized by antisera of infected animals. 2004.
    10.1196/annals.1307.024
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/01/01 - 2024/06/30 Full humanized 3D melanoma skin model for physiological studies of tumor aggressiveness. This project aim is to produce an innovative three-dimensional (3D) melanoma model with cells involved in tumor immune response to study the underlying mechanisms affecting melanoma progression, invasion, and metastasis. The effect of current therapies, dabrafenib and pembrolizumab, also will be addressed.
Orientador
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/04/01 - 2021/12/20 3D reconstruções human skin-on-a-chip modelo for anti-inflmatory drug evaluation. The aim of this master thesis will be th edevelopment of a inflammation model in invitro developed human skin, as a tool for testing antinflammatory compounds.
Orientador
 Biologia Humana e Ambiente (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2020/09/01 - 2021/09/30 Aplicação tópica de bioflavonoides em epiderme humana reconstruída in vitro usando nanopartículas lipídicas. O trabalho de mestardo esta focado na utilização de miniemulsões para a produção de NLCs (Nanostructured Lipid Carriers) para o estudo de "drug delivery" em moelos de epiderme human reconstruída (RHE).
Coorientador
 Biologia Humana e Ambiente (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2016/03/01 - 2021/09/30 Fully-humanized Skin-on-a-chip for medical applications. This project aims at developing an innovative microfluidic system to grow and sustain a physiologically relevant human skin model and to access its potential applications.
Coorientador
 Biociências Moleculares (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/06/01 - 2021/06/30 Desenvolvimento de um modelo 3D in vitro de melanoma cutâneo completamente humanizado com células mononucleadas de sangue periférico (PBMCs).
Coorientador
 Biociências Moleculares (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019/09/01 - 2021/03/31 Development of 3D skin model for studies of the autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). THis work aims teh development of an Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) model in a invitro skin model.
Coorientador
 biologia molecular e genetica (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2020/02/01 - 2021/02/24 Development of an in vitro platform for a 3D microphysiological systems of human iPS-derived endothelial cells. This work aims the development of a chip for co-culture of cells to build up a 3D microvascular network.
Coorientador
 Engenharia de Materiais (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/10/01 - 2021/02/24 Development of substrates for reconstructed human dermis based on polyhydroxyalkanoates (PHAs) and FucoPol. This work demonstrated the potential of naturally derived P(HBHVHHx)/FucoPol scaffolds for the reconstruction of human dermis.
Coorientador
 Biotecnologia
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017/09/01 - 2019/10/18 Study of the effects of the culture condition in the permeation of reconstructed human skin. This work provides a preliminary insight into how these permeation parameters can be adjusted to produce an in vitro human epidermal equivalent that better resembles the in vivo human epidermis. Although it is clear that further study is needed as permeability values are still far from those observed in vivo.
Coorientador
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2017/09/01 - 2019/02/28 SuberSkin - plant defensive polymers in wound healing.
Coorientador
 Bioquímica para a Saúde (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2016/04/01 - 2017/09/12 Metabolomic analysis of the reconstructed epidermis cultivation protocol as a tool to improve the skin barrier properties. In this work, a metabolomic analysis of the supernatant of the culture process (exometabolome) was performed by proton nuclear magnetic resonance spectroscopy (1H-NMR) and high-performance liquid chromatography (HPLC). The uptake and secretion rates for both the expansion of keratinocytes in monolayer culture and the reconstructed epidermis were determined for the several metabolites observed by NMR, and for the amino acids.
Coorientador
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2014/09/01 - 2016/04/28 Development and Experimentation of New Tools for Bioassays with Red Blood Cells. The aim of this work was to develop new tools for handling and studying of erythrocytes. In this context, biological nanoprobes were developed, combining Quantum Dots nanoparticles with specific antibodies to detect proteins in erythrocytes. Also, a microfluidic platform was designed and constructed to evaluate the cytotoxic effect in single-cell analysis of used QDs.
Orientador
 Biotecnologia (Mestrado)
Universidade Nova de Lisboa, Portugal
2015/04/01 - 2015/12/09 Microfluidics: A New Look At Cell Migration Analysis. Studying the effect of the surrounding environment of the embryonic stem cells development is of highly relevance to understand its physiology. Different single-cell microchips were designed and manufactured to study the migration of mouse embryonic fibroblasts (MEFs) cells coated and not coated with fibronectin in response to an increase of serum concentration in the culture medium.
Orientador
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/09/01 - 2012/10/10 Impedance spectroscopy applied to the characterization of parasitized cells in a microfluidics platform. This work is essentially focused on the description of the implementation of the electronic component in a microfluidics device for molecular diagnostics for the characterization of parasitized cells, as well as in the microfabrication of the devices themselves.
Coorientador
 Ciências da Engenharia - Engenharia Biomédica e Biofísica (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2007/03/01 - 2012/09/07 Quantum Dots: Synthesis, Functionalization and Bioconjugation for Biological Applications. This work was based in teh development of Quantum Dots (QDs) for biological applications and to study the impact of CdSe/ZnS core-shell QDs in cytoxity and genotoxicity areas as well as their application in the electronic field will be also addressed in this doctoral work.Quantum dots, SILAR method, biocompatible, bioconjugation, immunofluorescence assays, Babesia bovis, cytotoxicity, genotoxicity and MAPLE technique.
Coorientador
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006/04/01 - 2009/04/30 Development of a new Babesia bovis diagnostic method and identification of new vaccine candidates
Orientador
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2002/06/01 - 2006/02/15 Identification and characterization of immunodominant proteins of Theileria uilenbergi to be used in the diagnosis of ovine theileriosis in China
Orientador
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1994/02/01 - 1998/09/20 Desenvolvimento de um imunossensor para o diagnóstico da peste suina africana
Orientador
 Bioquímica (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2022/02/08 Cell-based Micro Device as a Tool for Predictive Intestinal Responses
Arguente principal
 Maria Inês Guedes (Mestrado)
Universidade Nova de Lisboa Departamento de Física, Portugal
2020/09/15 Biocatalysis in microfluidic systems: Biosensing and rapid-screening applications. The work discusses the development of an enzymatic synthesis platform, a portable device for plant health assessment and platforms to contribute towards the development of colon cancer treatments.
Arguente principal
 Eduardo João Silva Brás (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/02/28 Thin-Film Silicon Microelectromechanical Systems for Mass Sensing and Biosensing Applications. This work discuses the development of cantilever for bioassays and MEMS including the construction by micro and nanomachining.
Arguente principal
 Rui Miguel Raposo Pinto (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/12/03 Optical Neurostimulation Spine Endoprosthesis. The research and experiments performed in this work hold a ”proof-of-concept” utility and serve as starting point for further development of the technologies applied to stimulate neural systems.
Arguente principal
 Ricardo Morgado Marques (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/12/03 Low cost rapid prototyping of a microfluidic bioreactor for electrochemical sensing of 3D cancer cell cultures. This work describes teh development of a microfluidic bioreactor to enable real time monitoring of cells in a 3D tissue engineered scaffold.
Arguente principal
 Pedro Miguel Quintas da Conceição (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/12/12 Microfluidic separation using aqueous two phase systems
Arguente principal
 Daniel Filipe Camarneiro Silva (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/12/12 Microfluidic separation using aqueous two phase systems. métodos de separação e purificação de biomoléculas já estabecidos com o uso de ATPS num dispositivo microfluidico. O método escolhido para ser integrado no sistema foi a electroforese.
Arguente
 Daniel Filipe Camarneiro Silva (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/12/11 Droplet Microfluidic Systems for Directed Evolution
Arguente principal
 Guilherme Araújo de Andrade (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/11/13 Magnetic components and microfluidics optimization on a Labon-a-Chip platform
Arguente principal
 João Ferreira Gil (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2008/03/20 - Atual Avaliador propostas de projetos de I&DT em Co-promoção no âmbito do QREN e Portugal 2020
Avaliador
 Agência Nacional de Inovação SA, Portugal Agência Nacional de Inovação SA

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2014/12/01 - Atual Post-Graduation program and University Extension Courses. ITQB NOVA offers several research training options each corresponding to a number of credits (ECTS) to be awarded as University Extension or Post-Graduation Courses. Summer students may apply to a short "Introduction to the Research Lab" course. University Extension Courses & Postgraduate Programme on Research Practice (Pós-Graduação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2005/09/01 - 2020/03/31 Biossensores. This course provides students with a generic view of the concepts underlying the design and production of biosensors (analytical sensors based on the combination of biological components and physicochemical transducers), as well as their technological variations, main applications and current and future challenges. The course's specific objectives are to introduce students to new sensory technologies in the field of biotechnology, namely with regard to its miniaturization. Engenharia de Micro e Nanotecnologias (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/11/18 - 2019/11/22 Nano-processes for life sciences. Doctoral Course Module "MolBios". The general learning objective is to make the student aware of the importance of nanotechnologies in general and in particular their applications to the study and control of biomolecular processes in vitro, ex vivo and in vivo. Biociências Moleculares (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2015/12/01 - Atual Coordinator of the ITQB-NOVA Postgraduate Programme on Research Practice and the Research Training Courses. ITQB NOVA offers several research training options each corresponding to a number of credits (ECTS) to be awarded as University Extension or Post-Graduation Courses. Selected students carry out their scientific training integrated in one of the research laboratories at ITQB NOVA (or within the Oeiras Associated Laboratory).
Coordenador
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2006/03/01 - Atual Member of the Sciecntific Council of the ITQB-UNL Antonio Xavier
Membro
 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal