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M. Helena Vasconcelos is presently Associate Professor with Habilitation at the Department of Biological Sciences of FFUP (Faculty of Pharmacy, University of Porto) and Leader of the Cancer Drug Resistance Group at i3S (Instituto de Investigação e Inovação em Saúde da Universidade do Porto). She obtained her first degree in Pharmaceutical Sciences from FFUP, Portugal (1991), an MSc in Analytical Chemistry from the University of Aberdeen, Scotland (1993) and a PhD from the Department of Chemistry, University of Aberdeen, Scotland (1996). She then moved to Ireland for a post-doctoral position as temporary Researcher at the University of Cork, which was followed by another post-doc position at IPATIMUP. She initiated her teaching career in 1999, while continuing her research career at IPATIMUP and latter at i3S. Helena's research focuses on the identification and validation of biomarkers of drug resistance and therapeutic targets to overcome drug resistance in cancer. In addition, she studies the activity of novel small molecules to counteract drug resistance mechanisms. Her work has led to the validation of therapeutic targets and the identification of "hit" small molecules. Helena has been the PI of national research grants and has also served as referee of research projects for national and international funding agencies. She has been a member of numerous scientific and organizing committees of national and international Meetings, Conferences and Workshops. She is also an Editor of the journals "Cancers" and "Molecules". Helena has also been a Management Committee Substitute Member of COST Action BM1202 "European Network on Microvesicles and Exosomes in Health and Disease" and was Work Group Leader and Management Committee Member of COST Action CA17104 "New diagnostic and therapeutic tools against multidrug resistance tumors". She was member of the Team, as Academic Consultant, of a COST Innovators Grant “Pan-European Educational Platform on Multidrug Resistant Tumours and Personalised Cancer Treatment - PANDORA". Helena was a member of the Board of GEIVEX "Spanish Group of Innovation and Research in Extracellular Vesicles" (2018-2021) and was co-coordinator of PNEV (Portuguese Network on Extracellular Vesicles, 2019-2024). She was a founding member of "Associação PNEV - Portuguese Network on Extracellular Vesicles" in 2024 and is since President of the General Assembly of this Association. She has supervised/co-supervised 10 PhD students who have successfully completed their degree and is currently supervising/co-supervising 8 other PhD students (2 of them have already submitted their thesis). She has successfully supervised/co-supervised 25 MSc students and is currently supervising/co-supervising 1 further MSc students. Helena has also guided 4 hired researchers at post-doctoral level, 7 researchers with post-doctoral grants and has trained numerous young researchers with initiation to research grants (BIs) or technician grants (BTI). She has published more than 130 peer-reviewed papers and 5 book chapters, having over 25.000 citations and an h-index of 43. ORCID: 0000-0002-7801-4643
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Identificação

Identificação pessoal

Nome completo
Maria Helena Vasconcelos Meehan

Nomes de citação

  • Vasconcelos, M. Helena

Identificadores de autor

Ciência ID
4516-5451-90E9
ORCID iD
0000-0002-7801-4643
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - Atual Investigador Coordenador (carreira) (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2011 - 2015 Investigador Coordenador (carreira) (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2002 - 2011 Investigador principal (carreira) (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1999 - 2002 Investigador (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1998 - 1999 Pós-doutorado (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1996 - 1997 Pós-doutorado (Investigação) University College Cork National University of Ireland, Irlanda

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2020 - Atual Professor Associado (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
2007 - 2020 Professor Auxiliar (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
2002 - 2007 Assistente (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
2002 - 2002 Assistente Estagiário (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
1999 - 2002 Professor Auxiliar (Docente Universitário) Instituto Universitário de Ciências da Saúde, Portugal
Produções

Publicações

Artigo em conferência
  1. Palmeira, A; Rodrigues, F; Sousa, E; Pinto, M; Vasconcelos, MH; Fernandes, MX. "Pharmacophore-Based Screening as a Clue for the Discovery of New P-Glycoprotein Inhibitors". 2010.
    10.1007/978-3-642-13214-8_23
Artigo em revista
  1. Branco, H; Xavier, CPR; Riganti, C; Vasconcelos, MH. "Hypoxia as a critical player in extracellular vesicles-mediated intercellular communication between tumor cells and their surrounding microenvironment". BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2025): https://www.authenticus.pt/P-017-ND2.
    10.1016/j.bbcan.2024.189244
  2. Barbosa, MAG; Kruschel, RD; Almeida, MJ; Pereira, RF; Xavier, CPR; Mccarthy, FO; Vasconcelos, MH. "Isoquinolinequinone N-oxides with diverging mechanisms of action induce collateral sensitivity against multidrug resistant cancer cells". EUROPEAN JOURNAL OF PHARMACOLOGY (2025): https://www.authenticus.pt/P-017-V1E.
    10.1016/j.ejphar.2024.177234
  3. Welsh, Joshua A.; Goberdhan, Deborah C. I.; O'Driscoll, Lorraine; Buzas, Edit I.; Blenkiron, Cherie; Bussolati, Benedetta; Cai, Houjian; et al. "Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches". Journal of Extracellular Vesicles 13 2 (2024): http://dx.doi.org/10.1002/jev2.12404.
    10.1002/jev2.12404
  4. Matos, BS; da Silva, SP; Vasconcelos, MH; Xavier, CPR. "Chemosensitizing effect of pentoxifylline in sensitive and multidrug-resistant non-small cell lung cancer cells". CANCER DRUG RESISTANCE (2024): https://www.authenticus.pt/P-010-JBN.
    10.20517/cdr.2024.04
  5. Teixeira-Marques, A; Monteiro-Reis, S; Montezuma, D; Lourenco, C; Oliveira, MC; Constancio, V; Sequeira, JP; et al. "Improved recovery of urinary small extracellular vesicles by differential ultracentrifugation". SCIENTIFIC REPORTS (2024): https://www.authenticus.pt/P-010-GGZ.
    10.1038/s41598-024-62783-9
  6. Teixeira, Ricardo G.; Mészáros, János P.; Matos, Beatriz; Côrte-Real, Leonor; Xavier, Cristina P.R.; Fontrodona, Xavier; Garcia, M. Helena; et al. "Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies". European Journal of Medicinal Chemistry 262 (2023): 115922. http://dx.doi.org/10.1016/j.ejmech.2023.115922.
    10.1016/j.ejmech.2023.115922
  7. Francisca Carvalhal; Ana Cristina Magalhaes; Rita Rebelo; Andreia Palmeira; Diana I. S. P. Resende; Fernando Durães; Miguel Maia; et al. Autor correspondente: M. Helena Vasconcelos. "Evaluation of the Cytotoxic and Antiviral Effects of Small Molecules Selected by In Silico Studies as Inhibitors of SARS-CoV-2 Cell Entry". Molecules (2023): https://www.mdpi.com/1420-3049/28/20/7204.
    10.3390/molecules28207204
  8. Polónia, Bárbara; Xavier, Cristina P.R.; Kopecka, Joanna; Riganti, Chiara; Vasconcelos, M. Helena. "The role of Extracellular Vesicles in glycolytic and lipid metabolic reprogramming of cancer cells: Consequences for drug resistance". Cytokine & Growth Factor Reviews 73 (2023): 150-162. http://dx.doi.org/10.1016/j.cytogfr.2023.05.001.
    10.1016/j.cytogfr.2023.05.001
  9. Rebelo, Rita; Xavier, Cristina P.R.; Giovannetti, Elisa; Vasconcelos, M. Helena. Autor correspondente: Vasconcelos, M. Helena. "Fibroblasts in pancreatic cancer: molecular and clinical perspectives". Trends in Molecular Medicine 29 6 (2023): 439-453. http://dx.doi.org/10.1016/j.molmed.2023.03.002.
    10.1016/j.molmed.2023.03.002
  10. Vasconcelos, Maria Helena; Palmeira, Andreia; Sousa, Sofia Martins; Xavier, Cristina Pinto Ribeiro. "Repurposing some of the Well-known Non-steroid Anti-inflammatoryDrugs (NSAIDs) for Cancer Treatment". Current Topics in Medicinal Chemistry 23 13 (2023): 1171-1195. http://dx.doi.org/10.2174/1568026623666230130150029.
    10.2174/1568026623666230130150029
  11. Rui Bergantim; Sara Peixoto da Silva; Bárbara Polónia; Mélanie Barbosa; André Albergaria; Jorge Lima; Hugo R. Caires; José E. Guimarães; M. Helena Vasconcelos. "Detection of Measurable Residual Disease Biomarkers in Extracellular Vesicles from Liquid Biopsies of Multiple Myeloma Patients—A Proof of Concept". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/22/13686.
    10.3390/ijms232213686
  12. M. Helena Vasconcelos; catherine passirani; Chiara Riganti. "Special Issue: “New Diagnostic and Therapeutic Tools against Multidrug-Resistant Tumors (STRATAGEM Special Issue, EU-COST CA17104)”". Cancers (2022): https://www.mdpi.com/2072-6694/14/22/5491.
    10.3390/cancers14225491
  13. Castro, Inês; Lopes-Rodrigues, Vanessa; Branco, Helena; Vasconcelos, M. Helena; Xavier, Cristina P. R.. "Establishing and characterizing a novel doxorubicin-resistant acute myeloid leukaemia cell line". Journal of Chemotherapy 35 4 (2022): 307-321. http://dx.doi.org/10.1080/1120009x.2022.2097432.
    10.1080/1120009x.2022.2097432
  14. Xavier, Cristina P.R.; Belisario, Dimas Carolina; Rebelo, Rita; Assaraf, Yehuda G.; Giovannetti, Elisa; Kopecka, Joanna; Vasconcelos, M. Helena. "The role of extracellular vesicles in the transfer of drug resistance competences to cancer cells". Drug Resistance Updates (2022): 100833. http://dx.doi.org/10.1016/j.drup.2022.100833.
    10.1016/j.drup.2022.100833
  15. Branco, Helena; Oliveira, Júlio; Antunes, Catarina; Santos, Lúcio L.; Vasconcelos, Maria Helena; Xavier, Cristina P. R.. "Pirfenidone Sensitizes NCI-H460 Non-Small Cell Lung Cancer Cells to Paclitaxel and to a Combination of Paclitaxel with Carboplatin". International Journal of Molecular Sciences 23 7 (2022): 3631. http://dx.doi.org/10.3390/ijms23073631.
    10.3390/ijms23073631
  16. Barbosa, Mélanie A. G.; Xavier, Cristina P. R.; Pereira, Rúben F.; Petrikaite, Vilma; Vasconcelos, M. Helena. "3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer Drugs". Cancers 14 1 (2021): 190. http://dx.doi.org/10.3390/cancers14010190.
    10.3390/cancers14010190
  17. Gonçalves, Ana Cristina; Richiardone, Elena; Jorge, Joana; Polónia, Bárbara; Xavier, Cristina P.R.; Salaroglio, Iris Chiara; Riganti, Chiara; et al. "Impact of cancer metabolism on therapy resistance – Clinical implications". Drug Resistance Updates 59 (2021): 100797. http://dx.doi.org/10.1016/j.drup.2021.100797.
    10.1016/j.drup.2021.100797
  18. Sousa, Diana; Lima, Raquel T.; Lopes-Rodrigues, Vanessa; Gonzalez, Esperanza; Royo, Félix; Xavier, Cristina P. R.; Falcón-Pérez, Juan M.; Vasconcelos, M. Helena. "Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles". Cells 10 11 (2021): 2886. http://dx.doi.org/10.3390/cells10112886.
    10.3390/cells10112886
  19. Rebelo, Rita; Polónia, Bárbara; Santos, Lúcio Lara; Vasconcelos, M. Helena; Xavier, Cristina P. R.. "Drug Repurposing Opportunities in Pancreatic Ductal Adenocarcinoma". Pharmaceuticals 14 3 (2021): 280. http://dx.doi.org/10.3390/ph14030280.
    10.3390/ph14030280
  20. Silva, Bruna R.; Rebelo, Rita; Rodrigues, Juliana M.; Xavier, Cristina P. R.; Vasconcelos, M. Helena; Queiroz, Maria-João R. P.. "Synthesis of Novel Methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates and Antitumor Activity Evaluation: Studies In Vitro and In Ovo Grafts of Chick Chorioallantoic Membrane (CAM) with a Triple Negative Breast Cancer Cell Line". Molecules 26 6 (2021): 1594. http://dx.doi.org/10.3390/molecules26061594.
    10.3390/molecules26061594
  21. Xavier, Cristina P.R.; Castro, Inês; Caires, Hugo R.; Ferreira, Dylan; Cavadas, Bruno; Pereira, Luisa; Santos, Lúcio L.; Oliveira, Maria J.; Vasconcelos, M. Helena. "Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine". Cancer Letters 501 (2021): 210-223. http://dx.doi.org/10.1016/j.canlet.2020.11.013.
    10.1016/j.canlet.2020.11.013
  22. da Silva, Sara Peixoto; Caires, Hugo R.; Bergantim, Rui; Guimarães, José E.; Vasconcelos, M. Helena. "miRNAs Mediated Drug Resistance in Hematological Malignancies". Seminars in Cancer Biology (2021): http://dx.doi.org/10.1016/j.semcancer.2021.03.014.
    10.1016/j.semcancer.2021.03.014
  23. Vasconcelos, M. Helena; Alcaro, Stefano; Arechavala-Gomeza, Virginia; Baumbach, Jan; Borges, Fernanda; Brevini, Tiziana A.L.; Rivas, Javier De Las; et al. "Joining European Scientific Forces to Face Pandemics". Trends in Microbiology 29 2 (2021): 92-97. http://dx.doi.org/10.1016/j.tim.2020.10.008.
    10.1016/j.tim.2020.10.008
  24. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280.
    10.1080/15548627.2020.1797280
  25. Gütschow, Michael; Vanden Eynde, Jean Jacques; Jampilek, Josef; Kang, CongBao; Mangoni, Arduino A.; Fossa, Paola; Karaman, Rafik; et al. "Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7". Molecules 25 13 (2020): 2968. http://dx.doi.org/10.3390/molecules25132968.
    10.3390/molecules25132968
  26. Palmeira, Andreia; Sousa, Emília; Köseler, Aylin; Sabirli, Ramazan; Gören, Tarik; Türkçüer, Ibrahim; Kurt, Özgür; Pinto, Madalena M.; Vasconcelos, M. Helena. "Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection". Pharmaceuticals 13 6 (2020): 132. http://dx.doi.org/10.3390/ph13060132.
    10.3390/ph13060132
  27. Oliveira, Manuel Castanheira de; Caires, Hugo R.; Oliveira, Maria J.; Fraga, Avelino; Vasconcelos, M. Helena; Ribeiro, Ricardo. "Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles". Cancers 12 6 (2020): 1400. http://dx.doi.org/10.3390/cancers12061400.
    10.3390/cancers12061400
  28. Pinto, Vanessa; Bergantim, Rui; Caires, Hugo R.; Seca, Hugo; Guimarães, José E.; Vasconcelos, M. Helena. "Multiple Myeloma: Available Therapies and Causes of Drug Resistance". Cancers 12 2 (2020): 407. http://dx.doi.org/10.3390/cancers12020407.
    10.3390/cancers12020407
  29. Diana Sousa; Rune Matthiesen; Raquel T. Lima; M. Helena Vasconcelos. "Deep Sequencing Analysis Reveals Distinctive Non-Coding RNAs When Comparing Tumor Multidrug-Resistant Cells and Extracellular Vesicles with Drug-Sensitive Counterparts". Cancers (2020): https://www.mdpi.com/2072-6694/12/1/200.
    10.3390/cancers12010200
  30. Correia, Cristiana; Xavier, Cristina P. R.; Duarte, Diana; Ferreira, Abigail; Moreira, Sara; Vasconcelos, M. Helena; Vale, Nuno. "Development of potent CPP6–gemcitabine conjugates against human prostate cancer cell line (PC-3)". RSC Medicinal Chemistry 11 2 (2020): 268-273. http://dx.doi.org/10.1039/c9md00489k.
    10.1039/c9md00489k
  31. Vasconcelos, M. Helena. "The role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance". Cells (2020):
    Publicado • 10.3390/cells9051141
  32. Jean Jacques Vanden Eynde; Arduino Aleksander Mangoni; Jarkko Rautio; Jérôme Leprince; Yasu-Taka Azuma; Alfonso T. García-Sosa; Christopher Hulme; et al. "Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6". Molecules (2019): https://www.mdpi.com/1420-3049/25/1/119.
    10.3390/molecules25010119
  33. Solida Long; Diana I. S. P. Resende; Anake Kijjoa; Artur M. S. Silva; Ricardo Fernandes; Xavier CP; M. Helena Vasconcelos; E Sousa; Madalena M. M. Pinto. "Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects". Molecules (2019): http://www.mdpi.com/1420-3049/24/3/534.
    10.3390/molecules24030534
  34. Mangoni, A.A.; Eynde, J.J.V.; Jampilek, J.; Hadjipavlou-Litina, D.; Liu, H.; Reynisson, J.; Sousa, M.E.; et al. "Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, New Hopes-5". Molecules 24 13 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068372771&partnerID=MN8TOARS.
    10.3390/molecules24132415
  35. Assaraf, Y.G.; Brozovic, A.; Gonçalves, A.C.; Jurkovicova, D.; Line, A.; Machuqueiro, M.; Saponara, S.; et al. "The multi-factorial nature of clinical multidrug resistance in cancer". Drug Resistance Updates 46 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072866477&partnerID=MN8TOARS.
    10.1016/j.drup.2019.100645
  36. Teixeira, A.; Dacunha, D.C.; Barros, L.; Caires, H.R.; Xavier, C.P.R.; Ferreira, I.C.F.R.; Vasconcelos, M.H.. "Eucalyptus globulus Labill. decoction extract inhibits the growth of NCI-H460 cells by increasing the p53 levels and altering the cell cycle profile". Food and Function 10 6 (2019): 3188-3197. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067554330&partnerID=MN8TOARS.
    10.1039/c8fo02466a
  37. Vasconcelos, M.H.; Caires, H.R.; Abols, A.; Xavier, C.P.R.; Line, A.. "Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance". Drug Resistance Updates 47 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074466138&partnerID=MN8TOARS.
    10.1016/j.drup.2019.100647
  38. Rodrigues, J.M.; Buisson, P.; Pereira, J.M.; Pinheiro, I.M.; Fernández-Marcelo, T.; Vasconcelos, M.H.; Berteina-Raboin, S.; Queiroz, M.-J.R.P.. "Synthesis of novel 8-(het)aryl-6H-pyrano[4',3':4,5]thieno[3,2-b]pyridines by 6-endo-dig cyclization of Sonogashira products and halolactonizations with Cu salts/NXS. Preliminary antitumor evaluation". Tetrahedron 75 10 (2019): 1387-1397. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060927833&partnerID=MN8TOARS.
    10.1016/j.tet.2019.01.054
  39. Vanessa, Lopes-Rodrigues; Cristina, P. R. Xavier; Diana, Sousa; Hugo, Osório; Yehuda, G. Assaraf; Raquel, T. Lima; M., Helena Vasconcelos. "ALIX protein analysis: storage temperature may impair results". Journal of Molecular and Clinical Medicine 2 2 (2019): 29. http://dx.doi.org/10.31083/j.jmcm.2019.02.7161.
    10.31083/j.jmcm.2019.02.7161
  40. Raquel T. Lima; Diana Sousa; Ana Sara Gomes; Nuno Mendes; Rune Matthiesen; Madalena Pedro; Franklim Marques; et al. "The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization". Molecules (2018): http://www.mdpi.com/1420-3049/23/12/3301.
    10.3390/molecules23123301
  41. Arduino Aleksander Mangoni; catherine guillou; Jean Jacques Vanden Eynde; Christopher Hulme; Josef Jampilek; Wei Li; Katalin Prokai-Tatrai; et al. "Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–4". Molecules (2018): http://www.mdpi.com/1420-3049/24/1/130.
    10.3390/molecules24010130
  42. Bizarro, A.; Sousa, D.; Lima, R.T.; Musso, L.; Cincinelli, R.; Zuco, V.; De Cesare, M.; Dallavalle, S.; Vasconcelos, M.H.. "Synthesis and evaluation of the tumor cell growth inhibitory potential of new putative HSP90 inhibitors". Molecules 23 2 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042237059&partnerID=MN8TOARS.
    10.3390/molecules23020407
  43. Pereira, J.M.; Peixoto, V.; Teixeira, A.; Sousa, D.; Barros, L.; Ferreira, I.C.F.R.; Vasconcelos, M.H.. "Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis". Food and Chemical Toxicology 118 (2018): 635-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048530061&partnerID=MN8TOARS.
    10.1016/j.fct.2018.06.006
  44. Théry, C.; Witwer, K.W.; Aikawa, E.; Alcaraz, M.J.; Anderson, J.D.; Andriantsitohaina, R.; Antoniou, A.; et al. "Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines". Journal of Extracellular Vesicles 7 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85057143501&partnerID=MN8TOARS.
    10.1080/20013078.2018.1535750
  45. Magalhães, D.B.; Castro, I.; Lopes-Rodrigues, V.; Pereira, J.M.; Barros, L.; Ferreira, I.C.F.R.; Xavier, C.P.R.; Vasconcelos, M.H.. "Melissa officinalis L. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis". Food and Function 9 6 (2018): 3134-3142. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048964207&partnerID=MN8TOARS.
    10.1039/c8fo00446c
  46. Long, S.; Resende, D.I.S.P.; Kijjoa, A.; Silva, A.M.S.; Pina, A.; Fernández-Marcelo, T.; Helena Vasconcelos, M.; Sousa, E.; Pinto, M.M.M.. "Antitumor activity of quinazolinone alkaloids inspired by marine natural products". Marine Drugs 16 8 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053736578&partnerID=MN8TOARS.
    10.3390/md16080261
  47. Lopes-Rodrigues, V.; Di Luca, A.; Mleczko, J.; Meleady, P.; Henry, M.; Pesic, M.; Cabrera, D.; et al. "Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85015308172&partnerID=MN8TOARS.
    10.1038/srep44541
  48. Vasconcelos, M.H.. "Special Issue: New Approaches to Counteract Drug Resistance in Cancer". Molecules 22 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009776397&partnerID=MN8TOARS.
    10.3390/molecules22010006
  49. Lopes-Rodrigues, V.; Oliveira, A.; Correia-da-Silva, M.; Pinto, M.; Lima, R.T.; Sousa, E.; Vasconcelos, M.H.. "A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells". Bioorganic and Medicinal Chemistry 25 2 (2017): 581-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007239958&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.11.023
  50. Reis, F.S.; Martins, A.; Vasconcelos, M.H.; Morales, P.; Ferreira, I.C.F.R.. "Functional foods based on extracts or compounds derived from mushrooms". Trends in Food Science and Technology 66 (2017): 48-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020040964&partnerID=MN8TOARS.
    10.1016/j.tifs.2017.05.010
  51. Silva, P.M.A.; Ribeiro, N.; Lima, R.T.; Andrade, C.; Diogo, V.; Teixeira, J.; Florindo, C.; et al. "Suppression of spindly delays mitotic exit and exacerbates cell death response of cancer cells treated with low doses of paclitaxel". Cancer Letters 394 (2017): 33-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014640901&partnerID=MN8TOARS.
    10.1016/j.canlet.2017.02.024
  52. Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356". Autophagy 12 2 (2016): 443-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054826264&partnerID=MN8TOARS.
    10.1080/15548627.2016.1147886
  53. Lopes-Rodrigues, V.; Di Luca, A.; Sousa, D.; Seca, H.; Meleady, P.; Henry, M.; Lima, R.T.; O'Connor, R.; Vasconcelos, M.H.. "Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells". Data in Brief 6 (2016): 1023-1027. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957899956&partnerID=MN8TOARS.
    10.1016/j.dib.2016.02.004
  54. Lopes-Rodrigues, V.; Di Luca, A.; Sousa, D.; Seca, H.; Meleady, P.; Henry, M.; Lima, R.T.; O'Connor, R.; Vasconcelos, M.H.. "Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells". Biochimica et Biophysica Acta - General Subjects 1860 3 (2016): 618-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953790097&partnerID=MN8TOARS.
    10.1016/j.bbagen.2015.12.011
  55. Reis, F.S.; Sousa, D.; Barros, L.; Martins, A.; Morales, P.; Ferreira, I.C.F.R.; Vasconcelos, M.H.. "Leccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell line". Food and Chemical Toxicology 90 (2016): 45-54. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957628785&partnerID=MN8TOARS.
    10.1016/j.fct.2016.02.005
  56. Xavier, C.P.R.; Pesic, M.; Helena Vasconcelos, M.. "Understanding cancer drug resistance by developing and studying resistant cell line models". Current Cancer Drug Targets 16 3 (2016): 226-237. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958952995&partnerID=MN8TOARS.
    10.2174/1568009616666151113120705
  57. Pereira, J.M.; Lopes-Rodrigues, V.; Xavier, C.P.R.; Lima, M.J.; Lima, R.T.; Ferreira, I.C.F.R.; Vasconcelos, M.H.. "An aqueous extract of Tuberaria lignosa inhibits cell growth, alters the cell cycle profile, and induces apoptosis of NCI-H460 tumor cells". Molecules 21 5 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84973659525&partnerID=MN8TOARS.
    10.3390/molecules21050595
  58. Lima, R.T.; Sousa, D.; Paiva, A.M.; Palmeira, A.; Barbosa, J.; Pedro, M.; Pinto, M.M.; Sousa, E.; Vasconcelos, M.H.. "Modulation of autophagy by a thioxanthone decreases the viability of melanoma cells". Molecules 21 10 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84992754198&partnerID=MN8TOARS.
    10.3390/molecules21101343
  59. Barbosa, J.; Lima, R.T.; Sousa, D.; Gomes, A.S.; Palmeira, A.; Seca, H.; Choosang, K.; et al. "Screening a small library of xanthones for antitumor activity and identification of a hit compound which induces apoptosis". Molecules 21 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85000443221&partnerID=MN8TOARS.
    10.3390/molecules21010081
  60. Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013763791&partnerID=MN8TOARS.
    10.1080/15548627.2015.1100356
  61. Lopes-Rodrigues, V.; Sousa, E.; Vasconcelos, M.H.. "Curcumin as a modulator of P-glycoprotein in cancer: Challenges and perspectives". Pharmaceuticals 9 4 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997077016&partnerID=MN8TOARS.
    10.3390/ph9040071
  62. Reis, F.S.; Barros, L.; Martins, A.; Vasconcelos, M.H.; Morales, P.; Ferreira, I.C.F.R.. "Leccinum molle (Bon) Bon and Leccinum vulpinum watling: The first study of their nutritional and antioxidant potential". Molecules 21 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84964680297&partnerID=MN8TOARS.
    10.3390/molecules21020246
  63. Fais, S.; O'Driscoll, L.; Borras, F.E.; Buzas, E.; Camussi, G.; Cappello, F.; Carvalho, J.; et al. "Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine". ACS Nano 10 4 (2016): 3886-3899. http://www.scopus.com/inward/record.url?eid=2-s2.0-84968866526&partnerID=MN8TOARS.
    10.1021/acsnano.5b08015
  64. Pereira, D.; Lima, R.T.; Palmeira, A.; Seca, H.; Soares, J.; Gomes, S.; Raimundo, L.; et al. "Design and synthesis of new inhibitors of p53-MDM2 interaction with a chalcone scaffold". Arabian Journal of Chemistry (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85014742778&partnerID=MN8TOARS.
    10.1016/j.arabjc.2016.04.015
  65. Vizetto-Duarte, C.; Custódio, L.; Acosta, G.; Lago, J.H.G.; Morais, T.R.; De Sousa, C.B.; Gangadhar, K.N.; et al. "Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds". PeerJ 2016 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84963983666&partnerID=MN8TOARS.
    10.7717/peerj.1704
  66. Sousa, D.; Lima, R.T.; Vasconcelos, M.H.. "Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles". Trends in Molecular Medicine 21 10 (2015): 595-608. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942521471&partnerID=MN8TOARS.
    10.1016/j.molmed.2015.08.002
  67. Bizarro, A.; Ferreira, I.C.F.R.; Sokovic, M.; Van Griensven, L.J.L.D.; Sousa, D.; Vasconcelos, M.H.; Lima, R.T.. "Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21". Molecules 20 8 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84941248202&partnerID=MN8TOARS.
    10.3390/molecules200813927
  68. Reis, F.S.; Lima, R.T.; Morales, P.; Ferreira, I.C.F.R.; Vasconcelos, M.H.. "Methanolic extract of ganoderma lucidum induces autophagy of AGS human gastric tumor cells". Molecules 20 10 (2015): 17872-17882. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946934938&partnerID=MN8TOARS.
    10.3390/molecules201017872
  69. Oliveira, A.S.; Sousa, E.; Vasconcelos, M.H.; Pinto, M.. "Curcumin: A natural lead for potential new drug candidates". Current Medicinal Chemistry 22 36 (2015): 4196-4232. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960971101&partnerID=MN8TOARS.
    10.2174/0929867322666151029104611
  70. Yáñez-Mó, M.; Siljander, P.R.-M.; Andreu, Z.; Zavec, A.B.; Borràs, F.E.; Buzas, E.I.; Buzas, K.; et al. "Biological properties of extracellular vesicles and their physiological functions". Journal of Extracellular Vesicles 4 2015 (2015): 1-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014619748&partnerID=MN8TOARS.
    10.3402/jev.v4.27066
  71. Ferreira, I.C.F.R.; Heleno, S.A.; Reis, F.S.; Stojkovic, D.; Queiroz, M.J.R.P.; Vasconcelos, M.H.; Sokovic, M.. "Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities". Phytochemistry 114 (2015): 38-55. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929709160&partnerID=MN8TOARS.
    10.1016/j.phytochem.2014.10.011
  72. De Oliveira, J.T.; Santos, A.L.; Gomes, C.; Barros, R.; Ribeiro, C.; Mendes, N.; De Matos, A.J.; et al. "Anti-influenza neuraminidase inhibitor oseltamivir phosphate induces canine mammary cancer cell aggressiveness". PLoS ONE 10 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929484710&partnerID=MN8TOARS.
    10.1371/journal.pone.0121590
  73. dos Santos, T.; Oliveira, M.; Sousa, D.; Lima, R.T.; Martins, A.; Ferreira, I.C.F.R.; Vasconcelos, M.H.. "Suillus luteus methanolic extract inhibits proliferation and increases expression of p-H2A.X in a non-small cell lung cancer cell line". Journal of Functional Foods 6 1 (2014): 100-106. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895069161&partnerID=MN8TOARS.
    10.1016/j.jff.2013.09.023
  74. Lopes-Rodrigues, V.; Seca, H.; Sousa, D.; Sousa, E.; Lima, R.T.; Vasconcelos, M.H.. "The network of P-glycoprotein and microRNAs interactions". International Journal of Cancer 135 2 (2014): 253-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900001904&partnerID=MN8TOARS.
    10.1002/ijc.28500
  75. Freitas, D.P.; Teixeira, C.A.; Santos-Silva, F.; Vasconcelos, M.H.; Almeida, G.M.. "Therapy-induced enrichment of putative lung cancer stem-like cells". International Journal of Cancer 134 6 (2014): 1270-1278. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891825186&partnerID=MN8TOARS.
    10.1002/ijc.28478
  76. Pereira, C.; Lopes-Rodrigues, V.; Coutinho, I.; Neves, M.P.; Lima, R.T.; Pinto, M.; Cidade, H.; Vasconcelos, M.H.; Saraiva, L.. "Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays". European Journal of Pharmaceutical Sciences 54 1 (2014): 8-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893050056&partnerID=MN8TOARS.
    10.1016/j.ejps.2013.12.017
  77. Oliveira, M.; Reis, F.S.; Sousa, D.; Tavares, C.; Lima, R.T.; Ferreira, I.C.F.R.; Dos Santos, T.; Vasconcelos, M.H.. "A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle". Food and Function 5 7 (2014): 1389-1394. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903278799&partnerID=MN8TOARS.
    10.1039/c4fo00258j
  78. Lima, M.J.; Sousa, D.; Lima, R.T.; Carvalho, A.M.; Ferreira, I.C.F.R.; Vasconcelos, M.H.. "Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of the NCI-H460 tumour cell line". Industrial Crops and Products 59 (2014): 149-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901403792&partnerID=MN8TOARS.
    10.1016/j.indcrop.2014.05.009
  79. Almeida, G.M.; Lima, R.T.; Seca, H.; Vasconcelos, M.H.; Bergantim, R.; Guimarães, J.E.; Sobrinho-Simões, M.. "Effect of miR-128 in DNA damage of HL-60 acute myeloid leukemia cells". Current Pharmaceutical Biotechnology 15 5 (2014): 492-502. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907184167&partnerID=MN8TOARS.
  80. Costa, E.V.; Sousa, E.; Choosang, K.; Singh, S.; Rocha, J.; Lima, R.T.; Pakkong, P.; et al. "Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase". Current Topics in Medicinal Chemistry 14 8 (2014): 1033-1044. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903714075&partnerID=MN8TOARS.
    10.2174/1568026614666140324124807
  81. Reis, F.S.; Stojkovic, D.; Barros, L.; Glamoclija, J.; Ciric, A.; Sokovic, M.; Martins, A.; et al. "Can Suillus granulatus (L.) Roussel be classified as a functional food?". Food and Function 5 11 (2014): 2861-2869. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908131518&partnerID=MN8TOARS.
    10.1039/c4fo00619d
  82. Seca, H; Lima, RT; Almeida, GM; Sobrinho Simoes, M; Bergantim, R; Guimaraes, JE; Vasconcelos, MH. "Effect of miR-128 in DNA Damage of HL-60 Acute Myeloid Leukemia Cells". CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2014): https://www.authenticus.pt/P-009-V68.
    10.2174/1389201015666140519122524
  83. Azevedo, C.M.G.; Afonso, C.M.M.; Sousa, D.; Lima, R.T.; Helena Vasconcelos, M.; Pedro, M.; Barbosa, J.; et al. "Multidimensional optimization of promising antitumor xanthone derivatives". Bioorganic and Medicinal Chemistry 21 11 (2013): 2941-2959. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877815889&partnerID=MN8TOARS.
    10.1016/j.bmc.2013.03.079
  84. Queiroz, M.-J.R.P.; Peixoto, D.; Calhelha, R.C.; Soares, P.; Dos Santos, T.; Lima, R.T.; Campos, J.F.; et al. "New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death". European Journal of Medicinal Chemistry 69 (2013): 855-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885340733&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.023
  85. Paiva, A.M.; Pinto, R.A.; Teixeira, M.; Barbosa, C.M.; Lima, R.T.; Vasconcelos, M.H.; Sousa, E.; Pinto, M.. "Development of noncytotoxic PLGA nanoparticles to improve the effect of a new inhibitor of p53-MDM2 interaction". International Journal of Pharmaceutics 454 1 (2013): 394-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884149481&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2013.07.017
  86. Santos, T.D.; Tavares, C.; Sousa, D.; Vaz, J.A.; Calhelha, R.C.; Martins, A.; Almeida, G.M.; Ferreira, I.C.F.R.; Vasconcelos, M.H.. "Suillus luteus methanolic extract inhibits cell growth and proliferation of a colon cancer cell line". Food Research International 53 1 (2013): 476-481. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879479075&partnerID=MN8TOARS.
    10.1016/j.foodres.2013.05.037
  87. Seca, H.; Lima, R.T.; Lopes-Rodrigues, V.; Guimarães, J.E.; Almeida, G.M.; Vasconcelos, M.H.. "Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells". Current Drug Targets 14 10 (2013): 1135-1143. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881353774&partnerID=MN8TOARS.
    10.2174/13894501113149990185
  88. Azevedo, C.M.G.; Afonso, C.M.M.; Soares, J.X.; Reis, S.; Sousa, D.; Lima, R.T.; Vasconcelos, M.H.; et al. "Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models". European Journal of Medicinal Chemistry 69 (2013): 798-816. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885009924&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.012
  89. Cazal, C.M.; Choosang, K.; Severino, V.G.P.; Fernandes, J.B.; da Silva, M.F.G.F.; Vieira, P.C.; Nascimento, M.S.J.; et al. "Natural compounds with cell growth inhibitory activity in human tumor cell lines". Anti-Cancer Agents in Medicinal Chemistry 13 10 (2013): 1582-1589. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898928442&partnerID=MN8TOARS.
    10.2174/1871520613666131125122857
  90. Lima, R.T.; Barron, G.A.; Grabowska, J.A.; Bermano, G.; Kaur, S.; Roy, N.; Vasconcelos, M.H.; Lin, P.K.T.. "Cytotoxicity and cell death mechanisms induced by a novel bisnaphthalimidopropyl derivative against the NCI-H460 non-small lung cancer cell line". Anti-Cancer Agents in Medicinal Chemistry 13 3 (2013): 414-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876702523&partnerID=MN8TOARS.
    10.2174/1871520611313030005
  91. Sousa, E.; Palmeira, A.; Cordeiro, A.S.; Sarmento, B.; Ferreira, D.; Lima, R.T.; Helena Vasconcelos, M.; Pinto, M.. "Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption". Medicinal Chemistry Research 22 5 (2013): 2115-2123. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879681792&partnerID=MN8TOARS.
    10.1007/s00044-012-0203-y
  92. Lima, R.T.; Seca, H.; Palmeira, A.; Fernandes, M.X.; Castro, F.; Correia-da-Silva, M.; Nascimento, M.S.J.; et al. "Sulfated small molecules targeting EBV in Burkitt lymphoma: From in silico screening to the evidence of in vitro effect on viral episomal DNA". Chemical Biology and Drug Design 81 5 (2013): 631-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876827905&partnerID=MN8TOARS.
    10.1111/cbdd.12109
  93. Lima, R.T.; Sousa, D.; Choosang, K.; Pakkong, P.; Palmeira, A.; Paiva, A.M.; Seca, H.; et al. "A Potent Thioxanthone which Induces Autophagy and Cell Death in a Melanoma Cell Line". Annals of Oncology 24 (2013): i23-i23. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083347628&partnerID=MN8TOARS.
    10.1093/annonc/mdt045.14
  94. Neves, M.P.; Cravo, S.; Lima, R.T.; Vasconcelos, M.H.; Nascimento, M.S.J.; Silva, A.M.S.; Pinto, M.; Cidade, H.; Corrêa, A.G.. "Solid-phase synthesis of 2'-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines". Bioorganic and Medicinal Chemistry 20 1 (2012): 25-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855202674&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.11.042
  95. Calhelha, R.C.; Ferreira, I.C.F.R.; Peixoto, D.; Abreu, R.M.V.; Vale-Silva, L.A.; Pinto, E.; Lima, R.T.; et al. "Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells". Molecules 17 4 (2012): 3834-3843. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860247243&partnerID=MN8TOARS.
    10.3390/molecules17043834
  96. Vaz, J.A.; Almeida, G.M.; Ferreira, I.C.F.R.; Martins, A.; Vasconcelos, M.H.. "Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential". Food Chemistry 132 1 (2012): 482-486. http://www.scopus.com/inward/record.url?eid=2-s2.0-84355166472&partnerID=MN8TOARS.
    10.1016/j.foodchem.2011.11.031
  97. Palmeira, A.; Sousa, E.; Vasconcelos, M.H.; Pinto, M.M.. "Three decades of P-gp Inhibitors: Skimming through several generations and scaffolds". Current Medicinal Chemistry 19 13 (2012): 1946-2025. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860535245&partnerID=MN8TOARS.
    10.2174/092986712800167392
  98. Palmeira, A.; Vasconcelos, M.H.; Paiva, A.; Fernandes, M.X.; Pinto, M.; Sousa, E.. "Dual inhibitors of P-glycoprotein and tumor cell growth: (Re)discovering thioxanthones". Biochemical Pharmacology 83 1 (2012): 57-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855198003&partnerID=MN8TOARS.
    10.1016/j.bcp.2011.10.004
  99. Neves, M.P.; Lima, R.T.; Choosang, K.; Pakkong, P.; De São José Nascimento, M.; Vasconcelos, M.H.; Pinto, M.; Silva, A.M.S.; Cidade, H.. "Synthesis of a natural chalcone and its prenyl analogs - Evaluation of tumor cell growth-inhibitory activities, and effects on cell cycle and apoptosis". Chemistry and Biodiversity 9 6 (2012): 1133-1143. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862534164&partnerID=MN8TOARS.
    10.1002/cbdv.201100190
  100. Belaz, K.R.A.; Denadai, M.; Almeida, A.P.; Lima, R.T.; Vasconcelos, M.H.; Pinto, M.M.; Cass, Q.B.; Oliveira, R.V.. "Enantiomeric resolution of albendazole sulfoxide by semipreparative HPLC and in vitro study of growth inhibitory effects on human cancer cell lines". Journal of Pharmaceutical and Biomedical Analysis 66 (2012): 100-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861222683&partnerID=MN8TOARS.
    10.1016/j.jpba.2012.03.012
  101. Palmeira, A.; Sousa, E.; Helena Vasconcelos, M.; Pinto, M.; Fernandes, M.X.. "Structure and Ligand-based design of P-glycoprotein inhibitors: A historical perspective". Current Pharmaceutical Design 18 27 (2012): 4197-4214. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866309751&partnerID=MN8TOARS.
    10.2174/138161212802430530
  102. Vaz, J.A.; Ferreira, I.C.F.R.; Tavares, C.; Almeida, G.M.; Martins, A.; Helena Vasconcelos, M.. "Suillus collinitus methanolic extract increases p53 expression and causes cell cycle arrest and apoptosis in a breast cancer cell line". Food Chemistry 135 2 (2012): 596-602. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863914727&partnerID=MN8TOARS.
    10.1016/j.foodchem.2012.04.127
  103. Palmeira, A.; Sousa, E.; Fernandes, M.X.; Pinto, M.M.; Helena Vasconcelos, M.. "Multidrug resistance reversal effects of aminated thioxanthones and interaction with cytochrome P450 3A4". Journal of Pharmacy and Pharmaceutical Sciences 15 1 (2011): 31-45. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856137888&partnerID=MN8TOARS.
  104. Kijjoa, A.; Santos, S.; Dethoup, T.; Manoch, L.; Almeida, A.P.; Vasconcelos, M.H.; Silva, A.; Gales, L.; Herz, W.. "Sartoryglabrins, analogs of ardeemins, from Neosartorya glabra". Natural Product Communications 6 6 (2011): 807-812. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959215170&partnerID=MN8TOARS.
  105. Queiroz, M.-J.R.P.; Calhelha, R.C.; Vale-Silva, L.A.; Pinto, E.; Almeida, G.M.; Vasconcelos, M.H.. "Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure-activity relationships, effects on the cell cycle and apoptosis". European Journal of Medicinal Chemistry 46 1 (2011): 236-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650510707&partnerID=MN8TOARS.
    10.1016/j.ejmech.2010.11.009
  106. Lima, R.T.; Seca, H.; Soares, P.; Nascimento, M.S.J.; Vasconcelos, M.H.. "EBV interferes with the sensitivity of burkitt lymphoma akata cells to etoposide". Journal of Cellular Biochemistry 112 1 (2011): 200-210. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651286710&partnerID=MN8TOARS.
    10.1002/jcb.22920
  107. Neves, M.P.; Cidade, H.; Pinto, M.; Silva, A.M.S.; Gales, L.; Damas, A.M.; Lima, R.T.; Vasconcelos, M.H.; Nascimento, M.D.S.J.. "Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis". European Journal of Medicinal Chemistry 46 6 (2011): 2562-2574. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955635866&partnerID=MN8TOARS.
    10.1016/j.ejmech.2011.03.047
  108. Lima, R.T.; Seca, H.; Brás, S.; Nascimento, M.S.J.; Vasconcelos, M.H.. "Treatment of Akata EBV-positive cells with doxorubicin causes more EBV reactivation than treatment with etoposide". Chemotherapy 57 3 (2011): 195-203. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955433172&partnerID=MN8TOARS.
    10.1159/000323627
  109. Palmeira, A.; Rodrigues, F.; Sousa, E.; Pinto, M.; Vasconcelos, M.H.; Fernandes, M.X.. "New uses for old drugs: Pharmacophore-based screening for the discovery of P-glycoprotein inhibitors". Chemical Biology and Drug Design 78 1 (2011): 57-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958812376&partnerID=MN8TOARS.
    10.1111/j.1747-0285.2011.01089.x
  110. Lima, R.T.; Busacca, S.; Almeida, G.M.; Gaudino, G.; Fennell, D.A.; Vasconcelos, M.H.. "MicroRNA regulation of core apoptosis pathways in cancer". European Journal of Cancer 47 2 (2011): 163-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650686123&partnerID=MN8TOARS.
    10.1016/j.ejca.2010.11.005
  111. Vaz, J.A.; Barros, L.; Martins, A.; Morais, J.S.; Vasconcelos, M.H.; Ferreira, I.C.F.R.. "Phenolic profile of seventeen Portuguese wild mushrooms". LWT - Food Science and Technology 44 1 (2011): 343-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956939571&partnerID=MN8TOARS.
    10.1016/j.lwt.2010.06.029
  112. Seca, H.; Lima, R.T.; Guimarães, J.E.; Vasconcelos, M.H.. "Simultaneous targeting of P-gp and XIAP with siRNAs increases sensitivity of P-gp overexpressing CML cells to imatinib". Hematology 16 2 (2011): 100-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952643800&partnerID=MN8TOARS.
    10.1179/102453311X12940641877803
  113. Vaz, J.A.; Barros, L.; Martins, A.; Santos-Buelga, C.; Vasconcelos, M.H.; Ferreira, I.C.F.R.. "Chemical composition of wild edible mushrooms and antioxidant properties of their water soluble polysaccharidic and ethanolic fractions". Food Chemistry 126 2 (2011): 610-616. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650679654&partnerID=MN8TOARS.
    10.1016/j.foodchem.2010.11.063
  114. Borralho, P.M.; Simões, A.E.S.; Gomes, S.E.; Lima, R.T.; Carvalho, T.; Ferreira, D.M.S.; Vasconcelos, M.H.; Castro, R.E.; Rodrigues, C.M.P.. "MiR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation". PLoS ONE 6 8 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80052061782&partnerID=MN8TOARS.
    10.1371/journal.pone.0023787
  115. Abreu, R.M.V.; Ferreira, I.C.F.R.; Calhelha, R.C.; Lima, R.T.; Vasconcelos, M.H.; Adega, F.; Chaves, R.; Queiroz, M.-J.R.P.. "Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2- carboxylate derivatives: In vitro evaluation, cell cycle analysis and QSAR studies". European Journal of Medicinal Chemistry 46 12 (2011): 5800-5806. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955172000&partnerID=MN8TOARS.
    10.1016/j.ejmech.2011.09.029
  116. Neves, MP; Cidade, H; Pinto, M; Silva, AMS; Gales, L; Damas, AM; Lima, RT; Vasconcelos, MH; de Sao Jose Nascimento, M. "ChemInform Abstract: Prenylated Derivatives of Baicalein and 3,7-Dihydroxyflavone: Synthesis and Study of Their Effects on Tumor Cell Lines Growth, Cell Cycle and Apoptosis.". ChemInform (2011): https://www.authenticus.pt/P-00N-HF9.
    10.1002/chin.201136201
  117. Cazal, C.M.; Choosang, K.; Severino, V.G.P.; Soares, M.S.; Sarria, A.L.F.; Fernandes, J.B.; Silva, M.F.G.F.; et al. "Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines". Anti-Cancer Agents in Medicinal Chemistry 10 10 (2010): 769-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952740999&partnerID=MN8TOARS.
  118. Ferreira, I.C.F.R.; Vaz, J.A.; Vasconcelos, M.H.; Martins, A.. "Compounds from wild mushrooms with antitumor potential". Anti-Cancer Agents in Medicinal Chemistry 10 5 (2010): 424-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953764513&partnerID=MN8TOARS.
    10.2174/1871520611009050424
  119. Queiroz, M.-J.R.P.; Calhelha, R.C.; Vale-Silva, L.A.; Pinto, E.; Lima, R.T.; Vasconcelos, M.H.. "Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki-Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle". European Journal of Medicinal Chemistry 45 12 (2010): 5628-5634. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649335089&partnerID=MN8TOARS.
    10.1016/j.ejmech.2010.09.014
  120. Seca, H.; Almeida, G.M.; Guimarães, J.E.; Vasconcelos, M.H.. "miR signatures and the role of miRs in acute myeloid leukaemia". European Journal of Cancer 46 9 (2010): 1520-1527. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952583849&partnerID=MN8TOARS.
    10.1016/j.ejca.2010.03.031
  121. Palmeira, A.; Paiva, A.; Sousa, E.; Seca, H.; Almeida, G.M.; Lima, R.T.; Fernandes, M.X.; Pinto, M.; Vasconcelos, M.H.. "Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone". Chemical Biology and Drug Design 76 1 (2010): 43-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953008434&partnerID=MN8TOARS.
    10.1111/j.1747-0285.2010.00978.x
  122. Vaz, J.A.; Heleno, S.A.; Martins, A.; Almeida, G.M.; Vasconcelos, M.H.; Ferreira, I.C.F.R.. "Wild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell lines". Food and Chemical Toxicology 48 10 (2010): 2881-2884. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956392342&partnerID=MN8TOARS.
    10.1016/j.fct.2010.07.021
  123. Kijjoa, Anake; Lima, Raquel; Vasconcelos, MariaHelena; Pinto, Madalena; Almeida, AnaPaula; Dethoup, Tida; Singburaudom, Narong. "The in vitro anticancer activity of the crude extract of the sponge-associated fungus Eurotium cristatum and its secondary metabolites". Journal of Natural Pharmaceuticals 1 1 (2010): 25. http://dx.doi.org/10.4103/2229-5119.73583.
    10.4103/2229-5119.73583
  124. Preto, A.; Gonçalves, J.; Rebocho, A.P.; Figueiredo, J.; Meireles, A.M.; Rocha, A.S.; Vasconcelos, H.M.; et al. "Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations". BMC Cancer 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70749088911&partnerID=MN8TOARS.
    10.1186/1471-2407-9-387
  125. Vasconcelos, M. Helena. "Overcoming K562Dox resistance to STI571 (Gleevec) by downregulation of P-gp expression using siRNAs". Cancer Therapy 5 (2007): 67-76.
  126. Lima, R.T.; Martins, L.M.; Guimarães, J.E.; Sambade, C.; Vasconcelos, M.H.. "Chemosensitization effects of XIAP downregulation in K562 leukemia cells". Journal of Chemotherapy 18 1 (2006): 98-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645103808&partnerID=MN8TOARS.
  127. Vasconcelos, M.H.; Maia, L.F.; Sousa, C.; Beleza, S.S.; Guimarães, J.E.. "Evidence for a specific intracellular localization of an antisense oligonucleotide in K562 cells". Journal of Pharmacological Sciences 99 1 (2005): 105-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-25444533328&partnerID=MN8TOARS.
    10.1254/jphs.SCE05001X
  128. Lima, R.T.; Martins, L.M.; Guimarães, J.E.; Sambade, C.; Vasconcelos, M.H.. "Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells". Cancer Gene Therapy 11 5 (2004): 309-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342538514&partnerID=MN8TOARS.
    10.1038/sj.cgt.7700706
  129. Vasconcelos, M.H.; Tam, S.-C.; Hesketh, J.E.; Reid, M.; Beattie, J.H.. "Metal- and tissue-dependent relationship between metallothionein mRNA and protein". Toxicology and Applied Pharmacology 182 2 (2002): 91-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036354616&partnerID=MN8TOARS.
    10.1006/taap.2002.9428
  130. Vasconcelos, M.H.; Beleza, S.S.; Quirk, C.; Maia, L.F.; Sambade, C.; Guimarães, J.E.. "Limited synergistic effect of antisense oligonucleotides against bcr-abl and transferrin receptor mRNA in leukemic cells in culture". Cancer Letters 152 2 (2000): 135-143. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034194852&partnerID=MN8TOARS.
    10.1016/S0304-3835(99)00441-3
  131. Higgins, S.; Vasconcelos, M.H.; O'Brien, N.M.. "Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts". Mutagenesis 14 3 (1999): 335-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032946013&partnerID=MN8TOARS.
    10.1093/mutage/14.3.335
  132. Hesketh, J.E.; Vasconcelos, M.H.; Bermano, G.. "Regulatory signals in messenger RNA: Determinants of nutrient-gene interaction and metabolic compartmentation". British Journal of Nutrition 80 4 (1998): 307-321. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031794724&partnerID=MN8TOARS.
  133. Vasconcelos, M.H.; Tam, S.-C.; Beattie, J.H.; Hesketh, J.E.. "Evidence for differences in the post-transcriptional regulation of rat metallothionein isoforms". Biochemical Journal 315 2 (1996): 665-671. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029872621&partnerID=MN8TOARS.
  134. Vasconcelos, M.H.; Tam, S.-C.; Beattie, J.H.; Hesketh, J.E.. "Uptake and effects of antisense oligodeoxynucleotides specific for rat metallothionein -1 and -2 mRNA in H4 rat hepatoma cells in culture". Biochemical Society Transactions 24 3 (1996): http://www.scopus.com/inward/record.url?eid=2-s2.0-17544390003&partnerID=MN8TOARS.
  135. Helena Vasconcelos, M.; Tam, S.-C.; Beattie, J.H.; Hesketh, J.E.. "A competitive prehybridisation assay for validating the specificity of oligonucleotide probes: Application for analysis of rat metallothionein -1 and -2 mRNA". Biochemical Society Transactions 24 2 (1996): http://www.scopus.com/inward/record.url?eid=2-s2.0-33749781035&partnerID=MN8TOARS.
  136. Vasconcelos, M. Helena. "Composés phénoliques de Galium aparine et G. broteroanum". Plantes Mèdicinales et Phytothérapie XXVI 1 (1993): 49-51.
    Publicado
  137. Seabra, R.M.; Vasconcelos, M.H.. "The analysis of commercially available Hypericum extracts,ANALISE DE AMOSTRAS DE HIPERICAO EXISTENTES NO MERCADO". Revista Portuguesa de Farmacia 42 3 (1992): 39-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026490216&partnerID=MN8TOARS.
  138. Seabra, R.M.; Vasconcelos, M.H.; Cruz Costa, M.A.; Correia Alves, A.. "Phenolic compounds from Hypericum perforatum and H. undulatum". Fitoterapia 63 5 (1992): 473-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026489422&partnerID=MN8TOARS.
Capítulo de livro
  1. Vasconcelos, M. Helena. Autor correspondente: Vasconcelos, M. Helena. "The Role of MicroRNAs in Mature B-Cell Neoplasias Drug Resistance". Elsevier, 2024.
    No prelo
  2. Soure, I.; Branco, H.; Sobrinho-Simões M.A.; Henriques A.G.; Vasconcelos, M. Helena; Xavier C.P.R.. Autor correspondente: Xavier C.P.R.. "The Role of Extracellular Vesicles in the Intercellular Transfer of Cancer Hallmarks and Drug Resistance Traits". In Advances in Cancer Research. Academic Reads, 2022.
    Publicado
  3. Vasconcelos, M. Helena. "Delivering miRNA modulators for cancer treatment". In Drug Targeting and Stimuli Sensitive Drug Delivery Systems. 2018.
    Publicado
  4. Vasconcelos, M. Helena. "Mushrooms as a Source of Compounds that Induce Programmed Cell Death in Tumour Cells". In Recent Progress in Medicinal Plants. 2016.
    Publicado
  5. Seca, H; Lima, RT; Vasconcelos, MH. "MicroRNAs in cancer drug resistance and drug sensitivity". 2014.
    10.1007/978-3-319-03725-7_11
  6. Vasconcelos, M. Helena. "EBV- associated cancers: Strategies for targeting the virus". In Microbial pathogens and strategies for combating them: science, technology and education. 2013.
    Publicado
Pré-impressão
  1. Sousa, SM; Branco, H; Avan, A; Palmeira, A; Morelli, L; Santos, LL; Giovannetti, E; Vasconcelos, MH; Xavier, CPR. "Darifenacin: a promising chitinase 3-like 1 inhibitor to tackle drug resistance in pancreatic ductal adenocarcinoma". 2024. https://www.authenticus.pt/P-016-XV3.
    10.1007/s00280-024-04712-1
  2. Branco, H; Rodrigues, CA; Oliveira, J; Mendes, N; Antunes, C; Amorim, I; Santos, LL; Vasconcelos, MH; Xavier, CPR. "Preclinical studies on the antitumor and non-toxic effect of combining pirfenidone with vinorelbine and carboplatin in non-small cell lung cancer". 2024. https://www.authenticus.pt/P-017-KA8.
    10.1002/ijc.35276
  3. Kruschel, RD; Barbosa, MAG; Almeida, MJ; Xavier, CPR; Vasconcelos, MH; McCarthy, FO. "Discovery of Potent Isoquinolinequinone N-Oxides to Overcome Cancer Multidrug Resistance". 2024. https://www.authenticus.pt/P-016-SAC.
    10.1021/acs.jmedchem.4c00705
Resumo em conferência
  1. Castro, I; Lopes Rodrigues, V; Xavier, CPR; Vasconcelos, MH. "gamma-H2AX, CYP3A and CYP2J2 overexpression in a drug-resistant acute myeloid leukemia cell line". 2018.
    10.1016/j.freeradbiomed.2018.04.278
  2. Pereira, JM; Peixoto, V; Teixeira, A; Sousa, D; Barros, L; Ferreira, ICFR; Vasconcelos, MH. "Achillea millefolium L. hydroethanolic extract has phenolic compounds and inhibits the growth of human tumor cell lines". 2018.
    10.1016/j.freeradbiomed.2018.04.477
  3. Magalhaes, DB; Castro, I; Lopes Rodrigues, V; Pereira, JM; Barros, L; Ferreira, ICFR; Xavier, CPR; Vasconcelos, MH. "Melissa Officinalis L. ethanolic extract interferes with cell cycle and induces apoptosis of non-small cell lung cancer cells". 2018.
    10.1016/j.freeradbiomed.2018.04.472
  4. Reis, FS; Stojkovic, D; Barros, L; Glamoclija, J; Ciric, A; Sokovic, M; Martins, A; et al. "Suillus granulatus (L.) Roussel as a source of bioactive compounds: Comparative study between mushrooms from different origins". 2014.
    10.1055/s-0034-1394595
  5. Seca, H; Lima, RT; Almeida, GM; Obrinho Simoes, M; Bergantim, R; Guimaraes, JE; Vasconcelos, MH. "Mir-128 and DNA Damage In Acute Myeloid Leukemia". 2013.
    10.1182/blood.v122.21.2533.2533
  6. Correia da Silva, M; Sousa, E; Cidade, H; Choosang, K; Pakkong, P; Vasconcelos, MH; Pinto, MMM. "In vitro antioxidant and antitumor evaluation of new sulfated antithrombotic small molecules". 2012.
  7. Seca, H; Lima, RT; Lopes Rodrigues, V; Guimaraes, JE; Almeida, GM; Vasconcelos, MH. "Antimir-21 Causes Autophagy in the K562 Cell Line and Sensitizes Cells to the Effect of Doxorubicin and Etoposide". 2012.
  8. Pereira, C; Vasconcelos, MH; Martins, L; Saraiva, L. "A yeast model for LRRK2: biological studies and screening for small-molecule inhibitors". 2010.
  9. Seca, H; Lima, RT; Guimaraes, JE; Vasconcelos, MH. "Evaluation of XIAP as a molecular target to increase sensitivity to imatinib.". 2006.
  10. Lima, RT; Guimaraes, JE; Vasconcelos, MH. "Overcoming resistance to imatinib mesylate in a CML cell line by downregulation of P-gp with siRNAs.". 2005.
  11. Maia, LF; Vasconcelos, MH; Sousa, C; Beleza, S; Guimaraes, JE. "Differential effect of an antisense oligonucleotide to the transferrin receptor in hematopoietic cell lines correlates to subcellular distribution of the oligonucleotide". 2000.
    10.1016/s0301-472x(00)00327-1