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Completed PhD and postdoctoral work, having pursued a career in biomedical research after practising clinically for some years. I have recently established my independent research group and am building my independent portfolio in translational cardiac cell biology research, to expand on my previous work in this field and to further develop my research career.
Identificação

Identificação pessoal

Nome completo
Andrew John Smith

Nomes de citação

  • Smith, Andrew

Identificadores de autor

Ciência ID
471F-96DF-9591
ORCID iD
0000-0001-7283-5611
Formação
Grau Classificação
2008/07
Concluído
 Neuroscience and Biomedical Systems (Doctor)
University of Glasgow, Reino Unido
"Excitotoxicity, Oxidative Stress and Neuroprotection in Cerebellar Granule Neurones" (TESE/DISSERTAÇÃO)
2001/07
Concluído
 Bachelor of Medicine and Bachelor of Surgery (MBChB) (Doctor)
University of Aberdeen, Reino Unido
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015/08/03 - Atual Investigador principal (carreira) (Investigação) University of Leeds, Reino Unido
2015 - Atual Investigador visitante (Investigação) Centre of Human & Aerospace Physiological Sciences, School of Biomedical Sciences, King’s College London, Reino Unido
2013/04 - 2015/06 Pós-doutorado (Investigação) Centre of Human & Aerospace Physiological Sciences, School of Biomedical Sciences, King’s College London, Reino Unido
2014 - 2015 Pós-doutorado (Investigação) Università Magna Graecia, Catanzaro, Italy, Itália
2009 - 2013 Pós-doutorado (Investigação) Research Institute of Sport and Exercise Sciences, Liverpool John Moores University, Reino Unido

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2005 - 2007 Assistente (Docente Universitário) Anatomy Department, University of Glasgow, Reino Unido

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2002 - 2003 2nd year House Surgeon Emergency Department, Christchurch Hospital, Nova Zelândia
2001 - 2002 House Officer St John’s Hospital and Howden Health Centre, Reino Unido
Projetos

Bolsa

Designação Financiadores
2016/10 - Atual PhD project examining the mechanisms of tyrosine kinase inhibitor toxicity on human cardiac stem cells
LARS
Investigador responsável
2016/02 - Atual pump-priming’ grant: £23,000 for study of a novel chemical tool for cell surface ‘biopsies’ from cardiac cells
105615/Z/14/Z
Investigador responsável
2016/02 - Atual study into tyrosine kinase inhibitor cardiotoxicity and cardiac stem cells;
M519
Investigador responsável
2014/10 - 2016/01 study into mechanisms of quiescence in endogenous cardiac stem cells
R1405168
Investigador responsável
King’s Health Partners Research Fund
Concluído

Projeto

Designação Financiadores
2019/05 - Atual Identifying VEGFR roles in cardiac stem cell contribution to new vascular cell formation
PG/18/39/33618
Investigador responsável
2019/03 - Atual Utilising Novel 3-D bioprinting technology to translate in vitro toxicology findings into complex structures
2019-08
Investigador responsável
2014/11 - 2016/11 study of effects of tyrosine kinase inhibitors on the characteristics of endogenous cardiac stem cells from the adult human heart in vitro
RG2641
Investigador responsável
Concluído
Produções

Publicações

Artigo em revista
  1. Andrew J. Smith; Kathleen E. Wright; Stephen P. Muench; Sophie Schumann; Adrian Whitehouse; Karen E. Porter; John Colyer. "Styrene maleic acid recovers proteins from mammalian cells and tissues while avoiding significant cell death". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-51896-1.
    10.1038/s41598-019-51896-1
  2. Iolanda Aquila; Eleonora Cianflone; Mariangela Scalise; Fabiola Marino; Teresa Mancuso; Andrea Filardo; Andrew J. Smith; et al. "c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration". Cell Death & Disease 10 6 (2019): https://doi.org/10.1038/s41419-019-1655-5.
    10.1038/s41419-019-1655-5
  3. Aquila I; Cianflore E; Scalise M; Marino F; Mancuso T; Marotta P; Fillardo A; et al. "c-kit Haploinsufficiency Impairs Adult Cardiac Stem Cell Growth, Myogenicity and Myocardial Regeneration". Cell Death and Disease (2019):
    Em revisão
  4. Smith, Andrew; Colyer J. "Styrene maleic acid recovers protein biomarkers from mammalian cells and tissues without causing cell death.". Scientific Reports (2019):
    Em revisão
  5. Munsey T; Smith, Andrew. "Toxicity of receptor tyrosine kinase inhibitors in adult rat cardiac fibroblasts.". Toxicology In Vitro (2019):
    Em revisão
  6. Vicinanza, Carla; Aquila, Iolanda; Scalise, Mariangela; Cristiano, Francesca; Marino, Fabiola; Cianflone, Eleonora; Mancuso, Teresa; et al. "Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification". Cell Death and Differentiation 24 12 (2017): 2101-2116. http://dx.doi.org/10.1038/cdd.2017.130.
    10.1038/cdd.2017.130
  7. Waring, Cheryl D.; Henning, Beverley J.; Smith, Andrew J.; Nadal-Ginard, Bernardo; Torella, Daniele; Ellison, Georgina M.. "Cardiac adaptations from 4 weeks of intensity-controlled vigorous exercise are lost after a similar period of detraining". Physiological Reports 3 2 (2015): e12302. http://dx.doi.org/10.14814/phy2.12302.
    10.14814/phy2.12302
  8. Smith, Andrew J; Lewis, Fiona C; Aquila, Iolanda; Waring, Cheryl D; Nocera, Aurora; Agosti, Valter; Nadal-Ginard, Bernardo; Torella, Daniele; Ellison, Georgina M. "Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart". Nature Protocols 9 7 (2014): 1662-1681. http://dx.doi.org/10.1038/nprot.2014.113.
    10.1038/nprot.2014.113
  9. Ellison, Georgina M.; Vicinanza, Carla; Smith, Andrew J.; Aquila, Iolanda; Leone, Angelo; Waring, Cheryl D.; Henning, Beverley J.; et al. "Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair". Cell 154 4 (2013): 827-842. http://dx.doi.org/10.1016/j.cell.2013.07.039.
    10.1016/j.cell.2013.07.039
  10. Waring, Cheryl D.; Vicinanza, Carla; Papalamprou, Angela; Smith, Andrew J.; Purushothaman, Saranya; Goldspink, David F.; Nadal-Ginard, Bernardo; Torella, Daniele; Ellison, Georgina M.. "The adult heart responds to increased workload with physiologic hypertrophy, cardiac stem cell activation, and new myocyte formation". European Heart Journal 35 39 (2012): 2722-2731. http://dx.doi.org/10.1093/eurheartj/ehs338.
    10.1093/eurheartj/ehs338
  11. Ellison, Georgina M.; Torella, Daniele; Dellegrottaglie, Santo; Perez-Martinez, Claudia; Perez de Prado, Armando; Vicinanza, Carla; Purushothaman, Saranya; et al. "Endogenous Cardiac Stem Cell Activation by Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Intracoronary Injection Fosters Survival and Regeneration of the Infarcted Pig Heart". Journal of the American College of Cardiology 58 9 (2011): 977-986. http://dx.doi.org/10.1016/j.jacc.2011.05.013.
    10.1016/j.jacc.2011.05.013
  12. Kawaguchi, Nanako; Smith, Andrew J.; Waring, Cheryl D.; Hasan, Md Kamrul; Miyamoto, Shinka; Matsuoka, Rumiko; Ellison, Georgina M.. "c-kitpos GATA-4 High Rat Cardiac Stem Cells Foster Adult Cardiomyocyte Survival through IGF-1 Paracrine Signalling". PLoS ONE 5 12 (2010): e14297. http://dx.doi.org/10.1371/journal.pone.0014297.
    10.1371/journal.pone.0014297
  13. Darlington, L. Gail; Forrest, Caroline M.; Mackay, Gillian M.; Smith, Robert A.; Smith, Andrew J.; Stoy, Nicholas; Stone, Trevor W.. "On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio". International Journal of Tryptophan Research 3 (2010): IJTR.S4282. http://dx.doi.org/10.4137/ijtr.s4282.
    10.4137/ijtr.s4282
  14. Smith, Andrew J.; Tauskela, Joseph S.; Stone, Trevor W.; Smith, Robert A.. "Preconditioning with 4-aminopyridine protects cerebellar granule neurons against excitotoxicity". Brain Research 1294 (2009): 165-175. http://dx.doi.org/10.1016/j.brainres.2009.07.061.
    10.1016/j.brainres.2009.07.061
  15. Smith, Andrew J.; Smith, Robert A.; Stone, Trevor W.. "5-Hydroxyanthranilic Acid, a Tryptophan Metabolite, Generates Oxidative Stress and Neuronal Death via p38 Activation in Cultured Cerebellar Granule Neurones". Neurotoxicity Research 15 4 (2009): 303-310. http://dx.doi.org/10.1007/s12640-009-9034-0.
    10.1007/s12640-009-9034-0
  16. Smith, Andrew J.; Stone, Trevor W.; Smith, Robert A.. "Preconditioning with NMDA protects against toxicity of 3-nitropropionic acid or glutamate in cultured cerebellar granule neurons". Neuroscience Letters 440 3 (2008): 294-298. http://dx.doi.org/10.1016/j.neulet.2008.05.066.
    10.1016/j.neulet.2008.05.066
  17. Smith, A.J.; Stone, T.W.; Smith, R.A.. "Neurotoxicity of tryptophan metabolites". Biochemical Society Transactions 35 5 (2007): 1287-1289. http://dx.doi.org/10.1042/bst0351287.
    10.1042/bst0351287
Capítulo de livro
  1. Ellison, Georgina M.; Smith, Andrew J.; Waring, Cheryl D.; Henning, Beverley J.; Burdina, Anna O.; Polydorou, Joanna; Vicinanza, Carla; et al. "Adult Cardiac Stem Cells: Identity, Location and Potential". In Stem Cell Biology and Regenerative Medicine, 47-90. Springer New York, 2013.
    10.1007/978-1-4614-9569-7_4
Resumo em conferência
  1. Smith, Andrew. "Poor recovery from receptor tyrosine kinase inhibitor cardiotoxicity is linked to toxic effects on cardiac stem cells.". Trabalho apresentado em American Heart Association Scientific Sessions conference, Chicago IL, 2018.
  2. Smith, Andrew. "Cardiotoxic receptor tyrosine kinase inhibitors exert toxic effects on human cardiac stem cells and impair cardiac function". Trabalho apresentado em European Society of Cardiology Congress, Barcelona, 2017.
  3. Smith, Andrew. "Tyrosine kinase inhibitor cardiotoxicity and cardiac stem cells.". Trabalho apresentado em British Society for Cardiovascular Research conference ‘Cardiac Disease and Diabetes’, leeds, 2016.
  4. Smith, Andrew. "Cardiac Stem Cells - Advances, Uncertainties and Opportunities". Trabalho apresentado em Northern Cardiovascular Research Group congress, Leeds, 2016.
  5. Smith, Andrew. "In situ activation of endogenous cardiac stem cells alters their secretome, miRnome, potentiating their regenerative capacity on the injured heart". Trabalho apresentado em European Society of Cardiology Congress, londres, 2015.
  6. Smith, Andrew. "Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart.". Trabalho apresentado em World Biomedical Frontiers, Section of Stem Cells, 2015.
  7. Smith, Andrew. "In situ activation of endogenous cardiac stem cells alters their secretome, miRnome and potentiates their growth and self-renewal.". Trabalho apresentado em Physiological Society symposium H3 Symposia: Cellular approaches for cardiac repair: a physiological perspective, Londres, 2014.
  8. Smith, Andrew. "Activity status of resident adult cardiac stem cells determines their stem cell properties and growth kinetics". 2012.
  9. Smith, Andrew. "Endogenous cardiac stem cell (eCSC) activation, myogenesis and angiogenesis contribute to cardiac remodelling following intensity-controlled exercise training.". 2012.
  10. Smith, Andrew. "Resident adult cardiac stem cells fulfil Koch's postulates as the causative agents for myocardial regeneration and homeostasis". 2011.
  11. Smith, Andrew. "Roles of Wnt/beta-catenin and Tgf-Beta1/Smad2 signalling pathways in endogenous resident c-kit-positive cardiac stem cell proliferation and cardiomyogenic specification in vitro.". 2011.
  12. Bargo, Paulo R.; Chu, Melissa; Cole, Curtis A.; Kollias, Nikiforos. "Oxidative and nitrosative stress-induced neurotoxicity in primary rat cerebellar granule neurons.". 2009.
    10.1364/bio.2006.tui11
  13. Smith, Andrew. "Neurotoxicity of tryptophan metabolites in cultured cerebellar granule neurones. Proc. Life Sciences: C20". Trabalho apresentado em The Physiological Society Life Sciences 2007 conference, Glasgow, 2007.
  14. Smith, Andrew. "Effects of preconditioning on viability of cultured cerebellar neurones". Trabalho apresentado em at British Neuroscience Association conference, Harrogate, 2007.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2017/06 Use of Styrene Maleic Acid as a Novel Cardiovascular Cell Biopsy Tool. Nanoparticle technologies meeting
(Leeds, Reino Unido)
2016/04 Cardiac Stem Cells - Advances, Uncertainties and Opportunities. Northern Cardiovascular Research Group congress
(Leeds, Reino Unido)
2015/11 Endogenous cardiac stem cells’ activation in response to injury potentiates their regenerative ability. American Heart Association Scientific Sessions conference
(Orlando, Estados Unidos)
2013/11 Effects of in situ activation upon the properties and characteristics of endogenous cardiac stem cells. Regenerative Medicine: from biology to therapy’
(Cambridge, Reino Unido)
2011/07 Activity status of resident adult cardiac stem cells determines their stem cell properties and growth kinetics. European Society of Sports Science conference
(Liverpool, Reino Unido)
2010/11 Resident adult rat cardiac stem cells fulfil Koch’s postulates as the causative agents for myocardial regeneration and homeostasis American Heart Association Scientific Sessions conference
(Chicago IL, Estados Unidos)
2007/07 Neurotoxicity of tryptophan metabolites in cultured cerebellar granule neurones The Physiological Society Life Sciences 2007 conference
(Glasgow, Reino Unido)
2006/08 Effects of preconditioning on viability of cultured cerebellar neurones Institute of Biological Sciences
National Research Council of Canada (Ottawa, Canadá)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2017/07 - Atual British Heart Foundation
2016/02 - Atual Scientific Reports
2016/01 - Atual Medical Research Council
2016/01 - Atual Europace
2016 - Atual Rosetrees Trust
2014/04 - Atual Journal of Biomedical Science
2014/03 - Atual Scandinavian Journal of Medicine and Science in Sports