Bruno Costa da Silva (4A16-3B86-CF3C)

Curriculum Vitae

Bruno Costa da Silva

I have training in cells biology, including cellular and molecular neurobiology, developmental biology and oncology. During my postdoctoral training I spearheaded a project to investigate how tumor-derived extracellular vesicles (EVs) induce a series of cell-to-cell signalling and tissue remodelling events that support liver metastasis, showing for the first time the detailed mechanism of hepatic pre-metastatic niches formation (Costa-Silva et al, Nature Cell Biology, 2015). In addition, I participated on the first description of genomic double-stranded DNA packaging in tumor-derived exosomes and co-first authored a project, which showed that particular exosomal integrins define the tissue affinity of tumor-derived exosomes and as consequence tumor organotropism (Hoshino, Costa-Silva et al., Nature, 2015). Since 2016, when I established the first group to research cancer biology at the Champalimaud Foundation, I maintain productive collaborations with our Clinical Center and other European institutions, as a member since 2019 of the recently founded European Liquid Biopsies Society. In the last few years our group has focused on identifying new or poorly understood biological functions of EVs, issues we believe may impact all diseases (oncologic or not) mediated by EVs. More specifically, we are interested in occurrences after exocytosis of EVs; i.e. protein interactions and their biological implications, e.g. the activity of EVs and their bound proteins. For that, we have developed of functional EVs protein interaction assays (unpublished) applicable for cancer patient’s diagnosis, based on the capability of EVs to interact with specific proteins of interest. To further explore that, our group has successfully developed new technologies that enable mapping and monitoring of interactions between EVs and proteins; e.g. a vesicles flow cytometry method that enables fast analysis of EVs’ surface composition (Maia et al. 2020). Our group has successfully used this method for expedited analysis of proteins at the surface of EVs from cancer patient-derived plasma samples (unpublished results).

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Identificação

Identificação pessoal

Nome completo: Bruno Costa da Silva

Nomes de citação

Costa-Silva, Bruno

Identificadores de autor

Ciência ID: 4A16-3B86-CF3C
ORCID iD: 0000-0002-5932-6211
Google Scholar ID: 5uz9pbMAAAAJ&hl

Endereços de correio eletrónico

bruno.costadasilva@research.fchampalimaud.org (Profissional)

Moradas

Champalimaud Centre for the Unknown. Av. Brasília, Doca de Pedrouços, 1400-038, Lisboa, Lisboa, Portugal (Profissional)

Websites

https://fchampalimaud.org/pt-pt/research/groups/costa-silva (Académico)

Domínios de atuação

Ciências Naturais - Ciências Biológicas - Biologia Celular
Ciências Naturais - Ciências Biológicas - Biologia Molecular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2016/02 - Atual	Investigador principal (carreira) (Investigação)	Programa Champalimaud de Neurociências, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2015/07/01 - 2015/12/01	Instructor of Cellular and Developmental Biology	Weill Cornell Medicine, Estados Unidos

2013/03/01 - 2015/12/01	Visiting Scientist at Richard Kolesnick's Laboratory	Memorial Sloan Kettering Cancer Center, Estados Unidos

2011/08/01 - 2015/07/01	Postdoctoral training - David Lyden's Laboratory	Weill Cornell Medicine, Estados Unidos

Projetos

Projeto

	Designação	Financiadores
2019 - 2023	Defining the Role of Exosome-Secreted Micropeptides in Pancreatic Cancer LCF/PR/HR19/52160014 Investigador Fundação Champalimaud, Portugal	Em curso
2018 - 2023	Tumor- and stroma-derived exosomes populations associated with liver metastasis 3921 Investigador responsável Fundação Champalimaud, Portugal	European Molecular Biology Laboratory Em curso
2018 - 2021	Developmental and transgenerational effects of oxytocin-like peptides on social behavior: an eco-evo-devo approach using zebrafish as a model PTDC/BIA-COM/30627/2017 Investigador Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021	Diffuse Large B-cell lymphoma blood-based proteome signatures PTDC/BTM-TEC/30087/2017 Investigador Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021	Bosutinib effects in pre-metastatic niche formation and lung metastasis in breast cancer 2017NovPCC1058 Investigador responsável Fundação Champalimaud, Portugal	Breast Cancer Now Em curso
2018 - 2021	European Liquid Biopsies Academy - Towards widespread clinical application of blood based diagnostic tools 765492	European Commission
2018 - 2021	Metabolic chronic diseases stratification: a case for gut-liver axis derived exosomes PTDC/MEC-MET/29314/2017	Fundação para a Ciência e a Tecnologia
2018 - 2021	The role of metastatic microenvironment in Multiple Myeloma extramedullary disease. (EMphAsIS: Extramedular MyelomA mIcroenvironment Study) PTDC/MEC-HEM/30315/2017	Fundação para a Ciência e a Tecnologia
2017 - 2019	Phenotypic characterization of Liver-derived exosomes populations associated with liver metastasis in pancreatic cancers 751547 Investigador	European Commission Concluído

Produções

Publicações

Artigo em revista

Patrícia Amorim Gomes; Cristian Bodo; Carlos Nogueras-Ortiz; Martina Samiotaki; Minghao Chen; Carina Soares-Cunha; Joana Silva; et al. "A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology". Cell Communication and Signaling 21 1 (2023): http://dx.doi.org/10.1186/s12964-023-01045-z.
10.1186/s12964-023-01045-z
Inês Figueira; Paulo Bastos; Antonio González-Sarrías; Juan Carlos Espín; Bruno Costa-Silva; Claudia Nunes dos Santos. "Can exosomes transfer the preconditioning effects triggered by (poly)phenol compounds between cells?". Food & Function 14 1 (2023): 15-31. http://dx.doi.org/10.1039/d2fo00876a.
10.1039/d2fo00876a
Patrícia Gomes; Foteini Tzouanou; Konstantina Skolariki; Anastasia Vamvaka-Iakovou; Carlos Noguera-Ortiz; Katerina Tsirtsaki; Clarissa L. Waites; et al. "Extracellular vesicles and Alzheimer’s disease in the novel era of Precision Medicine: implications for disease progression, diagnosis and treatment". Experimental Neurology 358 (2022): 114183-114183. http://dx.doi.org/10.1016/j.expneurol.2022.114183.
10.1016/j.expneurol.2022.114183
Rune Matthiesen; Paula Gameiro; Andreia Henriques; Cristian Bodo; Maria Carolina Strano Moraes; Bruno Costa-Silva; José Cabeçadas; et al. "Extracellular Vesicles in Diffuse Large B Cell Lymphoma: Characterization and Diagnostic Potential". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232113327.
10.3390/ijms232113327
Nuno Couto; Julia Elzanowska; Joana Maia; Silvia Batista; Catarina Esteves Pereira; Hans Christian Beck; Carvalho AS; et al. "IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic Cancer". Cells 11 18 (2022): 2800-2800. http://dx.doi.org/10.3390/cells11182800.
10.3390/cells11182800
Teresa Faria Pais; Hajrabibi Ali; Joana Moreira da Silva; Nadia Duarte; Rita Neres; Chintan Chhatbar; Rita C Acúrcio; et al. "Brain endothelial STING1 activation by Plasmodium -sequestered heme promotes cerebral malaria via type I IFN response". Proceedings of the National Academy of Sciences 119 36 (2022): http://dx.doi.org/10.1073/pnas.2206327119.
10.1073/pnas.2206327119
"Multiple Myeloma-Derived Extracellular Vesicles Modulate the Bone Marrow Immune Microenvironment". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.909880.
10.3389/fimmu.2022.909880
"Defining Optimal Conditions for Tumor Extracellular Vesicle DNA Extraction for Mutation Profiling". Cancers 14 13 (2022): 3258-3258. http://dx.doi.org/10.3390/cancers14133258.
10.3390/cancers14133258
"Patient-Derived Extracellular Vesicles Proteins as New Biomarkers in Multiple Myeloma - A Real-World Study". Frontiers in Oncology 12 (2022): http://dx.doi.org/10.3389/fonc.2022.860849.
10.3389/fonc.2022.860849
Cristina Almeida; Ana L Teixeira; Francisca Dias; Vera Machado; Mariana Gomes Morais; Gabriela Martins; Carlos Palmeira; et al. "Extracellular Vesicles Derived-LAT1 mRNA as a Powerful Inducer of Colorectal Cancer Aggressive Phenotype". Biology (2022): https://www.mdpi.com/2079-7737/11/1/145.
10.3390/biology11010145
Catarina M. Abreu; Bruno Costa-Silva; Rui L. Reis; Subhas C. Kundu; David Caballero. "Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer". Lab on a Chip (2022): https://doi.org/10.1039/D2LC00006G.
10.1039/D2LC00006G
Ana Sofia Carvalho; Henrique Baeta; Andreia F. A. Henriques; Mostafa Ejtehadifar; Erin M. Tranfield; Ana Laura Sousa; Ana Farinho; et al. "Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping". International Journal of Molecular Sciences 22 20 (2021): 11004-11004. https://doi.org/10.3390/ijms222011004.
10.3390/ijms222011004
Luis Enrique Cortés-Hernández; Zahra Eslami-S; Bruno Costa-Silva; Catherine Alix-Panabières. "Current Applications and Discoveries Related to the Membrane Components of Circulating Tumor Cells and Extracellular Vesicles". Cells (2021): https://doi.org/10.3390/cells10092221.
10.3390/cells10092221
Cheila Brito; Bruno Costa-Silva; Duarte C. Barral; Marta Pojo. "Unraveling the Relevance of ARL GTPases in Cutaneous Melanoma Prognosis through Integrated Bioinformatics Analysis". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22179260.
10.3390/ijms22179260
Inês Figueira; Joana Godinho-Pereira; Sofia Galego; Joana Maia; János Haskó; Kinga Molnár; Rui Malhó; et al. "MicroRNAs and Extracellular Vesicles as Distinctive Biomarkers of Precocious and Advanced Stages of Breast Cancer Brain Metastases Development". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22105214.
10.3390/ijms22105214
Costa-Silva, Bruno. "Transcriptome Reprogramming of CD11b+ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.592518.
10.3389/fcell.2020.592518
Carvalho AS; Maria Carolina Strano Moraes; Chan Hyun Na; Ivo Fierro-Monti; Andreia Almeida Henriques; Sara Zahedi; Cristian Bodo; et al. "Is the Proteome of Bronchoalveolar Lavage Extracellular Vesicles a Marker of Advanced Lung Cancer?". Cancers (2020): https://www.mdpi.com/2072-6694/12/11/3450.
10.3390/cancers12113450
Costa-Silva, Bruno. "Employing Flow Cytometry to Extracellular Vesicles Sample Microvolume Analysis and Quality Control". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.593750.
10.3389/fcell.2020.593750
Julia Elzanowska; Christine Semira; Bruno Costa-Silva. "DNA in extracellular vesicles: biological and clinical aspects". Molecular Oncology (2020): https://doi.org/10.1002/1878-0261.12777.
10.1002/1878-0261.12777
Costa-Silva, Bruno. "Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers". Cell 182 4 (2020): 1044-1061.e18. http://dx.doi.org/10.1016/j.cell.2020.07.009.
10.1016/j.cell.2020.07.009
Francisca Dias; Ana Luísa Teixeira; Inês Nogueira; Mariana Morais; Joana Maia; Cristian Bodo; Marta Ferreira; et al. "Extracellular Vesicles Enriched in hsa-miR-301a-3p and hsa-miR-1293 Dynamics in Clear Cell Renal Cell Carcinoma Patients: Potential Biomarkers of Metastatic Disease". Cancers (2020): https://www.mdpi.com/2072-6694/12/6/1450.
10.3390/cancers12061450
Francisca Dias; Ana L Teixeira; Inês Nogueira; Mariana Gomes Morais; Joana Maia; Cristian Bodo; Marta Ferreira; et al. "Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study". International Journal of Molecular Sciences (2020): https://www.mdpi.com/1422-0067/21/13/4624.
10.3390/ijms21134624
Costa-Silva, Bruno. "Liquid biopsies for multiple myeloma in a time of precision medicine". Journal of Molecular Medicine (2020): http://dx.doi.org/10.1007/s00109-020-01897-9.
10.1007/s00109-020-01897-9
Matthiesen, Rune. "Extra-cellular vesicles carry proteome of cancer hallmarks". Frontiers in Bioscience 25 3 (2020): 398-436. http://dx.doi.org/10.2741/4811.
10.2741/4811
Costa-Silva, Bruno. "The Gastrointestinal Tumor Microenvironment: An Updated Biological and Clinical Perspective". Journal of Oncology (2019): http://dx.doi.org/10.1155/2019/6240505.
10.1155/2019/6240505
Costa-Silva, Bruno. "Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis". Nature Cell Biology (2019): http://dx.doi.org/10.1038/s41556-019-0404-4.
10.1038/s41556-019-0404-4
Silva, Bruno. "Label-free nanosensing platform for breast cancer exosome profiling". ACS Sensors (2019): http://dx.doi.org/10.1021/acssensors.9b00760.
10.1021/acssensors.9b00760
Inês Santiago; João Santinha; Andrada Ianus; Antonio Galzerano; Rita Theias; Joana Maia; Maria J. Barata; et al. "Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes". Cancer Research 79 9 (2019): 2435-2444. https://doi.org/10.1158/0008-5472.CAN-18-3682.
10.1158/0008-5472.CAN-18-3682
Silva, Bruno. "Exosomes as emerging players in cancer biology". Biochimie (2018): http://dx.doi.org/10.1016/j.biochi.2018.03.006.
10.1016/j.biochi.2018.03.006
Silva, Bruno. "Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer". HPB (2018): http://dx.doi.org/10.1016/j.hpb.2017.12.010.
10.1016/j.hpb.2017.12.010
Silva, Bruno. "Exosome-Based Cell-Cell Communication in the Tumor Microenvironment". Frontiers in Cell and Developmental Biology (2018): http://dx.doi.org/10.3389/fcell.2018.00018.
10.3389/fcell.2018.00018
Peinado, H.; Zhang, H.; Matei, I.R.; Costa-Silva, B.; Hoshino, A.; Rodrigues, G.; Psaila, B.; et al. "Pre-metastatic niches: Organ-specific homes for metastases". Nature Reviews Cancer 17 5 (2017): 302-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015629030&partnerID=MN8TOARS.
10.1038/nrc.2017.6
Melo, F.R.; Bressan, R.B.; Costa-Silva, B.; Trentin, A.G.. "Effects of Folic Acid and Homocysteine on the Morphogenesis of Mouse Cephalic Neural Crest Cells In Vitro". Cellular and Molecular Neurobiology 37 2 (2017): 371-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-84970939851&partnerID=MN8TOARS.
10.1007/s10571-016-0383-y
de Lacerda, T.C.S.; Costa-Silva, B.; Giudice, F.S.; Dias, M.V.S.; de Oliveira, G.P.; Teixeira, B.L.; dos Santos, T.G.; Martins, V.R.. "Prion protein binding to HOP modulates the migration and invasion of colorectal cancer cells". Clinical and Experimental Metastasis 33 5 (2016): 441-451. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964426890&partnerID=MN8TOARS.
10.1007/s10585-016-9788-8
Costa-Silva, B.; Aiello, N.M.; Ocean, A.J.; Singh, S.; Zhang, H.; Thakur, B.K.; Becker, A.; et al. "Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver". Nature Cell Biology 17 6 (2015): 816-826. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930170395&partnerID=MN8TOARS.
10.1038/ncb3169
Lopes, M.H.; Santos, T.G.; Rodrigues, B.R.; Queiroz-Hazarbassanov, N.; Cunha, I.W.; Wasilewska-Sampaio, A.P.; Costa-Silva, B.; et al. "Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival". Oncogene 34 25 (2015): 3305-3314. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934945282&partnerID=MN8TOARS.
10.1038/onc.2014.261
Hoshino, A.; Costa-Silva, B.; Shen, T.-L.; Rodrigues, G.; Hashimoto, A.; Tesic Mark, M.; Molina, H.; et al. "Tumour exosome integrins determine organotropic metastasis". Nature 527 7578 (2015): 329-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-84947723880&partnerID=MN8TOARS.
10.1038/nature15756
Thakur, B.K.; Zhang, H.; Becker, A.; Matei, I.; Huang, Y.; Costa-Silva, B.; Zheng, Y.; et al. "Double-stranded DNA in exosomes: A novel biomarker in cancer detection". Cell Research 24 6 (2014): 766-769. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901842265&partnerID=MN8TOARS.
10.1038/cr.2014.44
Hajj, G.N.M.; Arantes, C.P.; Dias, M.V.S.; Roffé, M.; Costa-Silva, B.; Lopes, M.H.; Porto-Carreiro, I.; et al. "The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles". Cellular and Molecular Life Sciences 70 17 (2013): 3211-3227. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882453351&partnerID=MN8TOARS.
10.1007/s00018-013-1328-y
Peinado, H.; Aleckovic, M.; Lavotshkin, S.; Matei, I.; Costa-Silva, B.; Moreno-Bueno, G.; Hergueta-Redondo, M.; et al. "Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET". Nature Medicine 18 6 (2012): 883-891. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862007577&partnerID=MN8TOARS.
10.1038/nm.2753
Santos, T.G.; Silva, I.R.; Costa-Silva, B.; Lepique, A.P.; Martins, V.R.; Lopes, M.H.. "Enhanced neural progenitor/stem cells self-renewal via the interaction of stress-inducible protein 1 with the prion protein". Stem Cells 29 7 (2011): 1126-1136. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960075550&partnerID=MN8TOARS.
10.1002/stem.664
Mendes-de-Aguiar, C.B.N.; Alchini, R.; Zucco, J.K.; Costa-Silva, B.; Decker, H.; Alvarez-Silva, M.; Tasca, C.I.; Trentin, A.G.. "Impaired astrocytic extracellular matrix distribution under congenital hypothyroidism affects neuronal development in vitro". Journal of Neuroscience Research 88 15 (2010): 3350-3360. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649419983&partnerID=MN8TOARS.
10.1002/jnr.22481
Costa-Silva, B.; da Costa, M.C.; Melo, F.R.; Neves, C.M.; Alvarez-Silva, M.; Calloni, G.W.; Trentin, A.G.. "Fibronectin promotes differentiation of neural crest progenitors endowed with smooth muscle cell potential". Experimental Cell Research 315 6 (2009): 955-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-61849094246&partnerID=MN8TOARS.
10.1016/j.yexcr.2009.01.015
Mendes-De-Aguiar, C.B.N.; Costa-Silva, B.; Alvarez-Silva, M.; Tasca, C.I.; Trentin, A.G.. "Thyroid hormone mediates syndecan expression in rat neonatal cerebellum". Cellular and Molecular Neurobiology 28 6 (2008): 795-801. http://www.scopus.com/inward/record.url?eid=2-s2.0-52949141505&partnerID=MN8TOARS.
10.1007/s10571-008-9260-7

Capítulo de livro

Ana Carolina Marques; Hugo Águas; Rodrigo Martins; Bruno Costa-Silva; Maria Goreti Sales; Elvira Fortunato. "Surface-enhanced Raman scattering paper-based analytical devices". 117-167. Elsevier, 2022.
10.1016/b978-0-12-820534-1.00001-3

Outros

Outra produção

Messages From the Small Intestine Carried by Extracellular Vesicles in Prediabetes: a Proteomic Portrait. Journal of Proteome Research. 2021. Inês Ferreira; Rita Machado de Oliveira; Ana Sofia Carvalho; Hans Christian Beck; Rune Matthiesen; Bruno Costa-Silva; Maria Paula Macedo; Akiko Teshima. https://doi.org/10.1101/2021.02.19.431856.
10.1101/2021.02.19.431856

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2019	Exosomes as emerging players in cancer biology and diagnostic applications	2019 Molecular Diagnostics Europe (Lisbon, Portugal)
2019	Extracellular Vesicles as emerging players in Tumor Biology	2019 Annual Scientific Meeting of the European Society for Clinical Investigation (Coimbra, Portugal)
2019	Exosomes-based cell-cell communication role in metastatic organotropism	2019 Else Kröner-Fresenius-Stiftung Symposium: Novel concepts in niche-directed cancer therapies (Frankfurt, Alemanha)
2019	Exosomes-based liquid biopsies	2019 European Organization for Research and Treatment of Cancer Meeting – Gynecological cancer group (Lisboa, Portugal)
2018	Population Analysis of Extracellular Vesicles	Exosomes/Microvesicles: Heterogeneity, Biogenesis, Function and Therapeutic Developments. Keystone Symposia (Beckenridge, Estados Unidos)
2017	Tumour exosomes – determination of organotropic metastases	2017 European Conference on Interventional Oncology (Bilbao, Espanha)
2017	Novel cell-cell communication networks in organotropic metastasis	2017 International Symposium of Young Scientists in Cancer Research (Berlin, Alemanha)
2016	On the origin of metastasis in the liver	2016 Workshop: The liver beyond surgery in colorectal metastatic disease (Lisboa, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2019/01/01 - Atual	Defining Optimal Conditions for Tumor Extracellular Vesicle DNA Extraction for Mutation Profiling Orientador de Julia Elzanowska	Molecular Biosciences (Doutoramento) Instituto de Tecnologia Química e Biológica António Xavier, Portugal Fundação Champalimaud, Portugal
2016/03/23 - Atual	IgG+ Extracellular Vesicles measure therapeutic response in advanced pancreatic cancer Orientador	Clinical Investigation (Doutoramento) Universidade Nova de Lisboa, Portugal Fundação Champalimaud, Portugal
2017/09/13 - 2022/03/23	NANOBIOSENSING PLATFORMS WITH SERS AND MIPBASED TECHNOLOGIES Coorientador	NANOCIÊNCIAS E NANOTECNOLOGIAS (Doutoramento) Universidade Nova de Lisboa, Portugal Fundação Champalimaud, Portugal
2016/11/13 - 2022/03/04	The role of extracellular vesicles in multiple myeloma Coorientador	Clinical Investigation (Doutoramento) Universidade Nova de Lisboa, Portugal Fundação Champalimaud, Portugal
2016/02/01 - 2021/05/25	Extracellular Vesicles: new population analysis methods and their role as messengers in tumor-stroma communication Orientador	Biologia Básica e Aplicada (Doutoramento) Universidade do Porto, Portugal Fundação Champalimaud, Portugal
2016/07/06 - 2021/01/27	Extracellular vesicles: agents of gut communication in prediabetes scenario Coorientador	Bioengenharia – Terapias Celulares e Medicina Regenerativa (Doutoramento) Universidade de Lisboa, Portugal Fundação Champalimaud, Portugal
2016/09/14 - 2017/12/14	Functional characterization of tumour-derived exosomes in the zebrafish xenograft model Orientador	Biologia Evolutiva e do Desenvolvimento (Mestrado) Universidade de Lisboa, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2019	New devices to monitor oxidative stress biomarkers in point-of-care: a new tool for cancer prevention	Gabriela Ferreira de Vasconcelos Martins (Doutoramento)
2019	Responses to liver damage: Macrophage plasticity in tissue recovery and dysbiotic drifts	Inês Couto Coelho (Doutoramento) Instituto Gulbenkian de Ciência, Portugal
2019	DEVELOPMENT OF A NANOBIT®-BASED CELLULAR SYSTEM TO CHARACTERIZE PROTACS IN LIVE KINETIC ASSAYS	Inês Graça Raposo (Mestrado)
2019	MECHANISMS UNDERLYING EXOSOMAL TRAFFICKING OF THE ANTIRETROVIRAL FACTOR APOBEC3G: IMPLICATIONS FOR THE CONTAINMENT AND ERADICATION OF HIV-1 INFECTION	Afonso Machado Mendes (Mestrado)
2017	¿Np63 is Critical for Progression of High Grade Non-Muscle Invasive Bladder Cancer Through Deregulation of Specific Genetic Pathways	Andreia Filipa Garrido Maia (Mestrado)
2016	ALS pathogenesis: role of motor neuron-derived exosomes in microglia activation and dysfunction Arguente	Sara Filipa Castro da Costa Pinto (Mestrado)

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2022/06/01 - 2022/06/30	5th ASPIC International Congress	IPO Porto

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2019 - Atual	Science
2019 - Atual	Analytical Chemistry
2019 - Atual	Frontiers in Immunology
2019 - Atual	Experimental Cell Research
2019 - Atual	International Journal of Molecular Sciences
2019 - Atual	Journal of Experimental & Clinical Cancer Research
2019 - Atual	Molecular Oncology
2019 - Atual	Cancers
2018 - Atual	The Breast
2018 - Atual	Proteome
2018 - Atual	Oncogene
2017 - Atual	Journal of Extracellular Vesicles
2017 - Atual	Journal of Cell Communication and Signaling
2017 - Atual	Pancreas
2017 - Atual	Molecular Oncology
2017 - Atual	eLife
2016 - Atual	Journal of Clinical Investigation
2015 - Atual	Brazilian Journal of Medical and Biological Research
2014 - Atual	Journal of Neuroscience Research

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2018 - 2018	Evaluation Committee for a position of Research Assistant Avaliador

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2018/11	Entrevista à Revista Sábado sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.	Revista Sábado
2018/02	Entrevista à Revista Sábado sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.	Revista Sábado
2017/11	Entrevista à Revista Sábado sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.	Revista Sábado

Entrevista / Programa (rádio / tv)

	Programa	Tema
2018/02 - Atual	Entrevista à TV Bandeirantes - Brasil (Jornal da Band) sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.
2017/09 - Atual	Entrevista à Antena 1 (90 segundos de ciência) sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.
2017/06 - Atual	Entrevista à TVI (Jornal da Uma) sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.
2017/06 - Atual	Entrevista à RTP (Bom dia Portugal) sobre projetos desenvolvidos no meu grupo de pesquisa na Fundação Champalimaud.

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2022/04/29 - Atual	Concurso para Atribuição de Bolsas de Investigação para Doutoramento 2022 (Biomedicina) - FCT Membro
2016 - 2019	Colloquium Committee Member Membro	Fundação Champalimaud, Portugal

Tutoria

	Tópico	Nome do aluno
2019 - Atual		Helena Gouveia, MD
2018 - Atual		Christine Semira, MD
2018 - Atual		Julia Elzanowska, MSc
2017 - Atual		Nuno Couto, MD
2016 - Atual		Joana Maia, MSc (GABBA Fellowship - PD/BD/105866/2014)

Distinções

Prémio

2017	Prémio Crioestaminal