Maria José de Oliveira Diógenes Nogueira (4B10-886B-DAFC)

Curriculum Vitae

Maria José de Oliveira Diógenes Nogueira

Maria José de Oliveira Diógenes has the "Agregação" (habilitation) in Medicina, Pharmacology since 2018 by Faculdade de Medicina, Universidade de Lisboa. In 2009, she obtained the PhD degree in Biomedical Sciences, Basic Neurosciences at Faculdade de Medicina, Universidade de Lisboa. In 2003 she acquired the title of Master in Neurosciences at Faculdade de Medicina, Universidade de Lisboa and in 2001 she received the Basic Degree in Pharmaceutical Sciences by Faculdade de Farmácia, Universidade de Lisboa. She is associate professor (Pharmacology and General Therapeutics) at Faculdade de Medicina, Universidade de Lisboa and lead a research group at Instituto de Medicina Molecular João Lobo Antunes. She published 46 articles in peer reviewed international journals. She is author of two book chapters. Maria José Diógenes won two very competitive National applications ("Projetos Santa Casa Neurociências, Prémio Mantero Belard 2017 " and "Projetos Santa Casa Neurociências, Prémio Mantero Belard 2021) for projects in the field of Neurodegenerative disorders (note that each year there is only one winner). The major focus of her research line is to deeply study the impairments in neurotrophic factors signaling in neurologic and neurodevelopmental disorders and to develop strategies to recover them. She supervised 6 post-docs, 9 PhD Students (6 completed), 25 Master's Students (25 compleated) and co-supervised 1 post-doc, 2 PhD and 5 Master's Students (5 completed).

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Identificação

Identificação pessoal

Nome completo: Maria José de Oliveira Diógenes Nogueira

Nomes de citação

Diógenes, MJ

Identificadores de autor

Ciência ID: 4B10-886B-DAFC
ORCID iD: 0000-0001-5486-6246

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Francês	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2018/02/28 Concluído	"Agregação" (Habilitation) in Medicine (Título de Agregado) Especialização em Pharmacology Universidade de Lisboa Faculdade de Medicina, Portugal "Não aplicável" (TESE/DISSERTAÇÃO)	unanimously approved
2009 Concluído	PhD in Biomedical Sciences (Doutoramento) Especialização em Basic Neurosciences Universidade de Lisboa Faculdade de Medicina, Portugal "Cross Talk Between Adenosine A24 Receptors and the Trk Receptors for Brain-derived Neurotrophic Factor (bdnf) at the Rat Hippocampus" (TESE/DISSERTAÇÃO)	Unanimously approved wit Distinction and Honors
2001 - 2003 Concluído	Master in Basic Neurosciences (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal "Neuromodulation of synaptic transmission by BDNF and adenosine in the hippocampus" (TESE/DISSERTAÇÃO)	19 out of 20
1995 - 2001 Concluído	PharmD Pharmaceutical Sciences (Licenciatura) Universidade de Lisboa Faculdade de Farmácia, Portugal	15 out of 20

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2015 - Atual	Investigador (Investigação)	Universidade de Lisboa Faculdade de Medicina, Portugal
	Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal (...)
2008 - 2009	Investigador (Investigação)	Universidade de Lisboa Faculdade de Medicina, Portugal
	Universidade de Lisboa Faculdade de Medicina, Portugal (...)
2003 - 2008	Investigador (Investigação)	Fundação para a Ciência e a Tecnologia, I.P., Portugal
	Universidade de Lisboa Faculdade de Medicina, Portugal (...)
2002 - 2003	Investigador (Investigação)	Fundação para a Ciência e a Tecnologia, I.P., Portugal
	Universidade de Lisboa Faculdade de Medicina, Portugal (...)

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2019 - Atual	Professor Associado (Docente Universitário)	Universidade de Lisboa Faculdade de Medicina, Portugal

2009 - 2019	Professor Auxiliar (Docente Universitário)	Universidade de Lisboa Faculdade de Medicina, Portugal

2004 - 2009	Professor Auxiliar Convidado (Docente Universitário)	Universidade de Lisboa Faculdade de Medicina, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2022/02 - Atual	Presidente	Portuguese Society of Pharmacology, Portugal
	Portuguese Society of Pharmacology, Portugal
2021 - Atual	Vice-President of the Pedagogical Council	Faculdade de Medicina, Universidade de Lisboa, Portugal

2017 - Atual	Member of the Medicines Evaluation Commission (CAM), Clinical Pharmacokinetic Expert	INFARMED - National Authority of Medicines and Health Products, I.P., Portugal
	INFARMED - National Authority of Medicines and Health Products, I.P., Portugal
2013 - Atual	Member of the fiscal council of the Association for Research and Development at FMUL	Faculdade de Medicina, Universidade de Lisboa, Portugal

2015 - 2019	Treasurer	Portuguese Society for Neurosciences, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2001 - 2002	Pharmaceutical Technician 1 Cl (Técnico Farmacêutico 1 Cl)	Farmácia Sália, Portugal

Projetos

Bolsa

	Designação	Financiadores
2020 - Atual	H2020 Twinning project: Epileptogenesis and Epilepsy Network:from genes, synapses and circuits to pave the way for novel drugs and strategies - Investigador Instituto de Medicina Molecular, Portugal	European Commission
2022/01/01 - 2025/01/01	TAT-TrkB, a novel neuroprotective compound to fight Alzheimer´s disease M000 Investigador responsável	Santa Casa da Misericórdia de Lisboa Em curso
2018/10/01 - 2021/09/30	Astrossoms: Artificial Astrocytes as regulators of neuronal comunication PTDC/BTM-SAL/32147/2017 Investigador Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/08/01 - 2021/07/31	TITANIC - CYP46A1 as a new TherapeutIcTAarget in NIemann-Pick type C disease PTDC/MED-NEU/29455/2017 Investigador Instituto de Medicina Molecular, Portugal Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/06/22 - 2021/06/21	Adenosine levels reestablishment: new approach for the treatment of Rett Syndrome PTDC/MED-NEU/31929/2017 Investigador responsável Instituto de Medicina Molecular, Portugal Universidade do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2017 - 2021	BDNF receptor cleavage: molecular consequences and possible application in Diagnostics and Therapeutics of Alzheimer’s Disease MB-37-2017 Investigador responsável Instituto de Medicina Molecular, Portugal	Santa Casa da Misericórdia de Lisboa
2017 - 2021	Regulation of adenosine levels as a new therapeutic strategy for Rett Syndrome SFRH/BD/118238/2016 Investigador responsável	Fundação para a Ciência e a Tecnologia Concluído
2018 - 2019	Molecular characterization of the endocannabinoid system in a mice model of Rett Syndrome: implications for possible cannabinoid-based therapies 20190017 Investigador responsável	Universidade de Lisboa Faculdade de Medicina Concluído
2017 - 2018	Impact of selective inhibition of cleavage of TrkB-FL mediated by calpains in synaptic plasticity 20180009 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Faculdade de Medicina, Universidade de Lisboa
2017 - 2018	Intracellular fragment of BDNF receptor (TrkB-ICD): Impact on genetic expression 20180015 Investigador responsável	Universidade de Lisboa Faculdade de Medicina
2014 - 2017	Neurophysiological mechanisms of aging: novel view of old concepts 57/12 Investigador responsável	Instituto de Medicina Molecular
2014 - 2017	Neurophysiological mechanisms of aging: novel view of old concepts 57/12	Instituto de Medicina Molecular
2014/04/01 - 2015/09/30	Adenosine receptors: new pharmacological targets for Rett syndrome treatment EXPL/BIM-MEC/0009/2013 Investigador responsável Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2014/04 - 2015/03	Adenosine receptors: new pharmacological targets for Rett syndrome treatment 133031 Provided by PTCRIS: 133031	Fundação para a Ciência e a Tecnologia, I.P.
2014 - 2015	Hebbian Plasticity-driven changes of synaptic homeostasis in Alzheimer’s Disease 20150010 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2014 - 2015	Role of microglial SIRT on synaptic plasticity in neuroinflammation 20150028 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2011/01 - 2014/06	Modulation of amyloid beta-induced neuronal toxicity via JNK: a novel role for tauroursodeoxycholic acid Provided by PTCRIS: 112636 112636 PTDC/SAU-NMC/112636/2009 Investigador Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia, I.P. Fundação para a Ciência e a Tecnologia Concluído
2013 - 2014	Adenosine A2A Receptors and Zinc: New Avenues for the Treatment of Rett - Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Fundação Calouste Gulbenkian Universidade de Lisboa Faculdade de Medicina Concluído
2013 - 2014	Microglial expression of SIRT2: impact on LTP 20140002 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2010/04/02 - 2013/04/01	Interaction between neurotrophic factor receptors (TrkB) and A2A adenosine receptors: implications for Amyotrophic Lateral Sclerosis PTDC/SAU-NEU/101752/2008 Investigador Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2013	Role of adenosine A2A receptors in the ß-amyloid peptide effect on BDNF signaling 20130018 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2011 - 2013	Unraveling the effect of different Abeta species upon hippocampal synaptic plasticity and the neuroprotective role of BDNF - Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Bayer Portugal, LDA Concluído
2011 - 2012	Long-Term Depression modulation by the brain-derived neurotrophic factor and the interplay with adenosine receptors 20120002 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Faculdade de Medicina, Universidade de Lisboa Concluído
2011 - 2012	Role of adenosine upon the actions of amiloid beta peptide on GABA release from rat synaptosomes 20120013 Investigador responsável	Universidade de Lisboa Faculdade de Medicina
2011 - 2012	How to prevent the effect of amyloid-beta peptide on the facilitatory action of BDNF upon glutamate release from rat sinaptosomes 2012020 Investigador responsável	Universidade de Lisboa Faculdade de Medicina Concluído
2011 - 2012	Influence of Amyloid-Beta Peptide in TrkB receptor isoforms 20120011 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2011 - 2012	How to prevent the effect of amyloid-beta peptide on the facilitatory action of BDNF upon glutamate release from rat sinaptosomes 2012020	Universidade de Lisboa Faculdade de Medicina
2008/05/25 - 2011/05/24	Membrane receptors and mediators involved in plastic changes induced by neuronal insults: implications for neuroprotection PTDC/SAU-FCF/68607/2006 Investigador Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010 - 2011	Influence of ß-amyloid protein on glutamate release in hippocampal presynaptic terminals 20110011 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2010 - 2011	Effect of ß-amyloid peptide on the release of GABA in rat hippocampus nerve endings 201100014 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2010 - 2011	Deciphering the mechanisms underlying memantine effects upon synaptic plasticity 201100015 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2009 - 2010	Effect of memantine on rat hippocampal long-term potentiation upon ageing 2010021 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2009 - 2010	Impact of neonatal administration of a neurotrophic factor-enriched diet on rat brain development 2010049 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2005 - 2010	Role of TrkB receptors in ageing - Investigador	Fundação Calouste Gulbenkian Concluído
2007 - 2008	Modulation of Long Term Depression (LTD) by Brain Derived Neurotrophic Factor (BDNF): influence of adenosine A2A receptors 2008022 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído
2005/08/15 - 2007/06/30	Neurotrophins and neuronal communication: regulation by adenosine POCI/SAU-NEU/56332/2004 Investigador Instituto de Medicina Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2006 - 2007	Modulation of apoptosis by BDNF and adenosine 2007011 Investigador responsável Universidade de Lisboa Faculdade de Medicina, Instituto de Farmacologia e Neurociências, Portugal	Universidade de Lisboa Faculdade de Medicina Concluído

Projeto

	Designação	Financiadores
2022/02/01 - 2025/01/31	Towards the development of a nanoparticle for early diagnosis of Alzheimer’s Disease, based on the reversible translocation of the blood brain barrier. PTDC/BTM-MAT/2472/2021 10.54499/PTDC/BTM-MAT/2472/2021 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2024 - 2025	TrkB-ICD as a diagnostic companion for a novel class of promising compounds in Alzheimer's disease - Universidade de Lisboa Faculdade de Medicina, Portugal	AstraZeneca Produtos Farmacêuticos Lda Em curso
2011/01/01 - 2013/02/17	Projecto Estratégico - LA 5 - 2011-2012 PEst-OE/SAU/LA0005/2011 Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Outro

	Designação	Financiadores
2023/01/01 - 2025/12/31	Novel treatment and early diagnostics of AD Pacto de Inovação “HfPT Investigador responsável Instituto de Medicina Molecular, Portugal	Em curso
2017 - 2018	Adenosinergic signaling as a new pharmacological target for schizophrenia treatment? 20180014 Investigador responsável	Universidade de Lisboa Faculdade de Medicina Concluído

Produções

Publicações

Artigo em conferência	Solá, Susana; Diógenes, Maria José; Brites, Dora; Rodrigues, Cecília M. "Bilirubin, amyloid ß-peptide, and glycochenodeoxycholate directly induce cytochrome c release from isolated mitochondria \| Libertação de citocromo c por interacção da bilirrubina, do ß-amilóide e do glicoquenodesoxicolato com mitocôndrias isoladas". 2002. Rodrigues, CMP; Solá, S; Silva, R.; Diógenes, MJ; Brites, D. "Apoptosis induced by deoxycholic acid, unconjugated bilirubin andamyloid ß-peptide reflects mitochondrial perturbation which may beinhibited by ursodeoxycholic acid". 2000. Publicado • 10.1016/s0168-8278(00)80482-1
Artigo em revista	Avelar P; Morais TP; de Castro Abrantes H; Adam Armada-Moreira; Valente CA; Sebastião, AM; Diógenes, MJ; Vaz SH. "Amyloid-ß peptide induces Ca2+ dysregulation in primary astrocytic cultures independently from BDNF effect". (2024): Em revisão Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Costa, Daniela; Moutinho, Miguel; Mateus, Joana; Mendes de Almeida, Rita; et al. "Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 3 (2024): 166993. http://dx.doi.org/10.1016/j.bbadis.2023.166993. 10.1016/j.bbadis.2023.166993 Salaciak, Kinga ; Lustyk, Klaudia; Szafarz, Malgorzata ; Pytka, Karolina; Inteiro-Oliveira, Sara; Diógenes, MJ; Xapelli, Sara; et al. Autor correspondente: Pytka, Karolina. "HBK-15, a multimodal compound, shows anti-amnesic effects in mice". Alzheimer's & Dementia: The journal of the Alzheimer's Association (2024): Submetido Inteiro-Oliveira, Sara; Ferreira-Manso, Mafalda; Costa-Coelho, Tiago; Nuno Alemãn-Serrano; Ribeiro-Rodrigues, Leonor; Ana Laura Duarte; Viais, Ricardo; et al. "Seizing epilepsy across neurological disorders highlighting BDNF/TrkB signaling and synaptic dysfunction". in preparation (2024): Fonseca-Gomes, João; Ribeiro-Rodrigues, Leonor; Mouro, Francisco M.; Paulo SP; Tanqueiro SR; Belo RF ; Miranda-Lourenço, Catarina; et al. Autor correspondente: Diógenes, MJ. "TrkB-ICD fragment promotes transcriptomic, proteomic, and synaptic alterations, driving recognition memory impairment in healthy rodents.". in preparation (2024): Abreu, Daniela Sofia; Gomes, Joana I.; Ribeiro, Filipa F.; Diógenes, Maria J.; Sebastião, Ana M.; Vaz, Sandra H.. "Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine". Frontiers in Cellular Neuroscience 17 (2023): http://dx.doi.org/10.3389/fncel.2023.1282841. 10.3389/fncel.2023.1282841 Miranda-Lourenço, Catarina; Rosa, Jéssica; Rei, Nádia; Belo, Rita F.; Lopes, Ana Luísa; Silva, Diogo; Vieira, Cátia; et al. "Adenosinergic System and BDNF Signaling Changes as a Cross-Sectional Feature of RTT: Characterization of Mecp2 Heterozygous Mouse Females". International Journal of Molecular Sciences 24 22 (2023): 16249. http://dx.doi.org/10.3390/ijms242216249. 10.3390/ijms242216249 Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E.; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, Luukas; et al. "S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5". Neurobiology of Disease 163 (2022): 105603. http://dx.doi.org/10.1016/j.nbd.2021.105603. 10.1016/j.nbd.2021.105603 Paulo, Sara L.; Miranda-Lourenço, Catarina; Belo, Rita F.; Rodrigues, Rui S.; Fonseca-Gomes, João; Tanqueiro, Sara R.; Geraldes, Vera; et al. "High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats". Current Issues in Molecular Biology 43 3 (2021): 2305-2319. http://dx.doi.org/10.3390/cimb43030162. 10.3390/cimb43030162 Diógenes, Maria José; Guimas Almeida, Cláudia; Xapelli, Sara. "Editorial: Meeting of the Portuguese Society for Neurosciences SPN2019". Frontiers in Molecular Neuroscience 14 (2021): http://dx.doi.org/10.3389/fnmol.2021.753500. 10.3389/fnmol.2021.753500 Paulo, Sara L.; Ribeiro-Rodrigues, Leonor; Rodrigues, Rui S.; Mateus, Joana M.; Fonseca-Gomes, João; Soares, Rita; Diógenes, Maria J.; et al. "Sustained Hippocampal Neural Plasticity Questions the Reproducibility of an Amyloid-ß-Induced Alzheimer’s Disease Model". Journal of Alzheimer's Disease 82 3 (2021): 1183-1202. http://dx.doi.org/10.3233/jad-201567. 10.3233/jad-201567 Tanqueiro, Sara R; Mouro, Francisco M; Ferreira, Catarina B; Freitas, Céline F; Fonseca-Gomes, João; Simões do Couto, Frederico; Sebastião, Ana M; Dawson, Neil; Diógenes, Maria J. "Sustained NMDA receptor hypofunction impairs brain-derived neurotropic factor signalling in the PFC, but not in the hippocampus, and disturbs PFC-dependent cognition in mice". Journal of Psychopharmacology 35 6 (2021): 730-743. http://dx.doi.org/10.1177/02698811211008560. 10.1177/02698811211008560 do Vale, FM; Diógenes, MJ; Barbacena, HA. "Controversies about the cardiovascular effects of OM3FA. Did inappropriate placebos skew clinical trial results?". Pharmacological Research 164 (2021): 105368. http://dx.doi.org/10.1016/j.phrs.2020.105368. Publicado • 10.1016/j.phrs.2020.105368 Miranda-Lourenço, C; Ribeiro-Rodrigues, L; Fonseca-Gomes, J; Tanqueiro, SR; Belo, RF; Ferreira, CB; Rei, N; et al. "Challenges of BDNF-based therapies: From common to rare diseases". Pharmacological Research* 162 (2020): 105281. http://dx.doi.org/10.1016/j.phrs.2020.105281. Acesso aberto • Publicado • 10.1016/j.phrs.2020.105281 Fonseca-Gomes, J; Loureiro, JA; Tanqueiro, SR; Mouro, FM; Ruivo, P; Carvalho, T; Sebastião, AM; Diógenes, MJ; Pereira, MC. "In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment". Nanomedicine 15 (2020): 8609-8621. Acesso aberto • Publicado • 10.2147/IJN.S267007 Miranda-Lourenço, C; Duarte, ST; Palminha, C; Gaspar, C; Rodrigues, TM; Magalhães-Cardoso, T; Rei, N; et al. "Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling". Neurobiology of Disease 145 (2020): 105043. Acesso aberto • Publicado • 10.1016/j.nbd.2020.105043 Lourenço, DM; Ribeiro-Rodrigues, L; Sebastião, AM; Diógenes, MJ; Xapelli, S. "Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy". International Journal of Molecular Sciences 21 19 (2020): 7309. http://dx.doi.org/10.3390/ijms21197309. Acesso aberto • Publicado • 10.3390/ijms21197309 Rodrigues, RS; Paulo, SL; Moreira, JB; Tanqueiro, SR; Sebastião, AM; Diógenes, MJ; Xapelli, S. "Adult Neural Stem Cells as Promising Targets in Psychiatric Disorders". Stem Cells and Development 29 17 (2020): 1099-1117. http://dx.doi.org/10.1089/scd.2020.0100. Publicado • 10.1089/scd.2020.0100 Belo, RF; Martins, MLF; Shvachiy, L; Costa-Coelho, T; de Almeida-Borlido, C; Fonseca-Gomes, J; Neves, V; et al. "The Neuroprotective Action of Amidated-Kyotorphin on Amyloid ß Peptide-Induced Alzheimer’s Disease Pathophysiology". Frontiers in Pharmacology 11 (2020): http://dx.doi.org/10.3389/fphar.2020.00985. Acesso aberto • Publicado • 10.3389/fphar.2020.00985 Sá de Almeida, J; Vargas, M; Fonseca-Gomes, J; Tanqueiro, SR; Belo, RF; Miranda-Lourenço, C; Sebastião, AM; Diógenes, MJ; Pais, TF. "Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices". Frontiers in Neuroscience 14 (2020): 614. Acesso aberto • Publicado • 10.3389/fnins.2020.00614 Xapelli, S; Diógenes, MJ; Crunelli, V; Fitzsimons, CP; Vaz, SH. "Editorial: Glial and Neural Stem Cells as New Therapeutic Targets for Neurodegenerative Disorders". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.00071. Acesso aberto • Publicado • 10.3389/fncel.2020.00071 Fonseca-Gomes, J; Rodrigues, TM; Vaz, Sandra H.; Ramalho, RM; Vicente-Miranda, H; Tanqueiro, S; Miranda-Lourenço, C; et al. "A Small TAT-TrkB Peptide Prevents BDNF Receptor Cleavage and Restores Synaptic Physiology in Alzheimer’s Disease". (2020): Em revisão Marcelino, H; Nogueira, VC; Santos, CRA; Quelhas, P; Carvalho, TMA; Fonseca-Gomes, J; Tomás, J; et al. "Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation". Journal of Neurochemistry 153 4 (2019): 455-467. http://dx.doi.org/10.1111/jnc.14937. Publicado • 10.1111/jnc.14937 Mouro, FM; Miranda-Lourenço, C; Sebastião, AM; Diógenes, MJ. "From Cannabinoids and Neurosteroids to Statins and the Ketogenic Diet: New Therapeutic Avenues in Rett Syndrome?". Frontiers in Neuroscience 13 680 (2019): http://dx.doi.org/10.3389/fnins.2019.00680. Acesso aberto • Publicado • 10.3389/fnins.2019.00680 Ruffolo, G; Cifelli, P; Miranda-Lourenço, C; De Felice, E; Limatola, C; Sebastião, AM; Diógenes, MJ; Aronica, E; Palma, E. "Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome". Neuroscience. pii: S0306-4522(19)30421-X (2019): http://dx.doi.org/10.1016/j.neuroscience.2019.06.015. Publicado • 10.1016/j.neuroscience.2019.06.015 Fonseca-Gomes, J; Jerónimo-Santos, A; Lesnikova, A; Casarotto, P; Castrén, E; Sebastião, AM; Diógenes, MJ. "TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins". Frontiers in Molecular Neuroscience 12 4 (2019): http://dx.doi.org/10.3389/fnmol.2019.00004. Acesso aberto • Publicado • 10.3389/fnmol.2019.00004 Tanqueiro, SR; Ramalho, RM; Rodrigues, TM; Lopes, LV; Sebastião, AM; Diógenes, MJ. "Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid ß". Frontiers in Pharmacology 9 237 (2018): http://dx.doi.org/10.3389/fphar.2018.00237. Acesso aberto • Publicado • 10.3389/fphar.2018.00237 Pinho, J; Vale, R; Batalha, VL; Costenla, AR; Dias, RB; Rombo, DM; Sebastião, AM; de Mendonça, A; Diógenes, MJ. "Enhanced LTP in aged rats: Detrimental or compensatory?". Neuropharmacology 114 (2017): 12-19. http://dx.doi.org/10.1016/j.neuropharm.2016.11.017. Publicado • 10.1016/j.neuropharm.2016.11.017 Sandau, US; Colino-Oliveira, M; Jones, A; Saleumvong, B; Coffman, SQ; Liu, L; Miranda-Lourenco, C; et al. "Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity". Journal of Neuroscience 36 48 (2016): 12117-12128. http://dx.doi.org/10.1523/jneurosci.2146-16.2016. Acesso aberto • Publicado • 10.1523/jneurosci.2146-16.2016 Moreira, A; Diógenes, MJ; de Mendonça, A; Lunet, N; Barros, H. "Chocolate Consumption is Associated with a Lower Risk of Cognitive Decline". Journal of Alzheimer's Disease 53 1 (2016): 85-93. http://dx.doi.org/10.3233/jad-160142. Publicado • 10.3233/jad-160142 Ribeiro, FF; Xapelli S; Miranda-Lourenço, C; Tanqueiro, SR; Fonseca-Gomes, J; Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "Purine nucleosides in neuroregeneration and neuroprotection". Neuropharmacology 104 (2016): 226-242. http://dx.doi.org/10.1016/j.neuropharm.2015.11.006. Publicado • 10.1016/j.neuropharm.2015.11.006 Vaz, SH; Lérias, SR; Parreira, S; Diógenes, MJ; Sebastião, AM. "Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes". Purinergic Signalling 11 4 (2015): 607-612. http://dx.doi.org/10.1007/s11302-015-9476-1. Acesso aberto • Publicado • 10.1007/s11302-015-9476-1 Jerónimo-Santos, A; Fonseca-Gomes, J; Guimarães, DA; Tanqueiro, SR; Ramalho, RM; Ribeiro, JA; Sebastião, AM; Diógenes, MJ. "Brain-derived neurotrophic factor mediates neuroprotection against Aß-induced toxicity through a mechanism independent on adenosine 2A receptor activation". Growth Factors 33 4 (2015): 298-308. http://dx.doi.org/10.3109/08977194.2015.1080696. Publicado • 10.3109/08977194.2015.1080696 Jerónimo-Santos, A; Batalha, VL; Müller, CE; Baqi, Y; Sebastião, AM; Lopes, LV; Diógenes, MJ. "Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP". Neuropharmacology 83 (2014): 99-106. http://dx.doi.org/10.1016/j.neuropharm.2014.04.006. Publicado • 10.1016/j.neuropharm.2014.04.006 Jerónimo-Santos, A; Vaz, SH; Parreira, S; Lérias, SR; Caetano, AP; Buée-Scherrer, V; Castrén, E; et al. "Dysregulation of TrkB Receptors and BDNF Function by Amyloid-ß Peptide is Mediated by Calpain". Cerebral Cortex 25 9 (2014): 3107-3121. http://dx.doi.org/10.1093/cercor/bhu105. Acesso aberto • Publicado • 10.1093/cercor/bhu105 Rodrigues, TM; Jerónimo-Santos, A; Sebastião, AM; Diógenes, MJ. "Adenosine A2A Receptors as novel upstream regulators of BDNF-mediated attenuation of hippocampal Long-Term Depression (LTD)". Neuropharmacology 79 (2014): 389-398. http://dx.doi.org/10.1016/j.neuropharm.2013.12.010. Publicado • 10.1016/j.neuropharm.2013.12.010 Rodrigues, TM; Jerónimo-Santos, A; Outeiro, TF; Sebastião, AM; Diógenes, MJ. "Challenges and Promises in the Development of Neurotrophic Factor-Based Therapies for Parkinson’s Disease". Drugs & Aging 31 4 (2014): 239-261. http://dx.doi.org/10.1007/s40266-014-0160-x. Publicado • 10.1007/s40266-014-0160-x Diógenes, MJ; Neves-Tome, R; Fucile, S; Martinello, K; Scianni, M; Theofilas, P; Lopatar, J; et al. "Homeostatic Control of Synaptic Activity by Endogenous Adenosine is Mediated by Adenosine Kinase". Cerebral Cortex 24 1 (2014): 67-80. http://dx.doi.org/10.1093/cercor/bhs284. Acesso aberto • Publicado • 10.1093/cercor/bhs284 Valadas, JS; Batalha, VL; Ferreira, DG; Gomes, R; Coelho, JE; Sebastião, AM; Diógenes, MJ; Lopes, LV. "Neuroprotection afforded by adenosine A2Areceptor blockade is modulated by corticotrophin-releasing factor (CRF) in glutamate injured cortical neurons". Journal of Neurochemistry 123 6 (2012): 1030-1040. http://dx.doi.org/10.1111/jnc.12050. Acesso aberto • Publicado • 10.1111/jnc.12050 Diógenes, MJ; Dias, RB; Rombo, DM; Vicente Miranda, H; Maiolino, F; Guerreiro, P; Nasstrom, T; et al. "Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation". Journal of Neuroscience 32 34 (2012): 11750-11762. http://dx.doi.org/10.1523/jneurosci.0234-12.2012. Acesso aberto • Publicado • 10.1523/jneurosci.0234-12.2012 Kemppainen, S; Rantamäki, T; Jerónimo-Santos, A; Lavasseur, G; Autio, H; Karpova, N; Kärkkäinen, E; et al. "Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice". Neurobiology of Aging 33 6 (2012): 1122.e23-1122.e39. http://dx.doi.org/10.1016/j.neurobiolaging.2011.11.006. Publicado • 10.1016/j.neurobiolaging.2011.11.006 Silva, SL; Vaz, AR; Diógenes, MJ; van Rooijen, N; Sebastião, AM; Fernandes, A; Silva, RFM; Brites, D. "Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10". Neuropharmacology 62 7 (2012): 2398-2408. http://dx.doi.org/10.1016/j.neuropharm.2012.02.002. Publicado • 10.1016/j.neuropharm.2012.02.002 Costenla, AR; Diógenes, MJ; Canas, PM; Rodrigues, RJ; Nogueira, C; Maroco, J; Agostinho, PM; et al. "Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing". European Journal of Neuroscience 34 1 (2011): 12-21. http://dx.doi.org/10.1111/j.1460-9568.2011.07719.x. Publicado • 10.1111/j.1460-9568.2011.07719.x Sebastião, AM; Assaife-Lopes, N; Diógenes, MJ; Vaz, SH; Ribeiro, JA. "Modulation of brain-derived neurotrophic factor (BDNF) actions in the nervous system by adenosine A2A receptors and the role of lipid rafts". Biochimica et Biophysica Acta (BBA) - Biomembranes 1808 5 (2011): 1340-1349. http://dx.doi.org/10.1016/j.bbamem.2010.06.028. Acesso aberto • Publicado • 10.1016/j.bbamem.2010.06.028 Diógenes, MJ; Costenla, AR; Lopes, LV; Jerónimo-Santos, A; Sousa, VC; Fontinha, BM; Ribeiro, JA; Sebastião, AM. "Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF". Neuropsychopharmacology 36 9 (2011): 1823-1836. http://dx.doi.org/10.1038/npp.2011.64. Acesso aberto • Publicado • 10.1038/npp.2011.64 Diógenes, MJ; Outeiro, TF. "Neurotrophic Factors as a Protective Strategy in Parkinsons Disease". CNS & Neurological Disorders - Drug Targets 9 6 (2010): 754-763. http://dx.doi.org/10.2174/187152710793237449. Publicado • 10.2174/187152710793237449 Fontinha, BM; Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine". Neuropharmacology 54 6 (2008): 924-933. http://dx.doi.org/10.1016/j.neuropharm.2008.01.011. Publicado • 10.1016/j.neuropharm.2008.01.011 Diógenes, MJ; Assaife-Lopes, N; Pinto-Duarte, A; Ribeiro, JA; Sebastião, AM. "Influence of age on BDNF modulation of hippocampal synaptic transmission: Interplay with adenosine A2A receptors". Hippocampus 17 7 (2007): 577-585. http://dx.doi.org/10.1002/hipo.20294. Publicado • 10.1002/hipo.20294 Pousinha, PA; Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "Triggering of BDNF facilitatory action on neuromuscular transmission by adenosine A2A receptors". Neuroscience Letters 404 1-2 (2006): 143-147. http://dx.doi.org/10.1016/j.neulet.2006.05.036. Publicado • 10.1016/j.neulet.2006.05.036 Diógenes, MJ; Fernandes, CC; Sebastião, AM; Ribeiro, JA. "Activation of Adenosine A2A Receptor Facilitates Brain-Derived Neurotrophic Factor Modulation of Synaptic Transmission in Hippocampal Slices". Journal of Neuroscience 24 12 (2004): 2905-2913. http://dx.doi.org/10.1523/jneurosci.4454-03.2004. Acesso aberto • Publicado • 10.1523/jneurosci.4454-03.2004 Solá, S; Diógenes, MJ; Brites, D; Rodrigues, CMP. "Release of cytochrome C with the interaction of bilirubin, amyloid beta-peptide and glycochenodeoxycholate from isolated mitochondria". Acta Médica Portuguesa 25 4 (2002): 269-275. http://europepmc.org/abstract/med/12525020. Acesso aberto • Publicado • 10.20344/amp.1964
Capítulo de livro	Diógenes, MJ; Duarte, ST; Sebastião, AM. "Fármacos antiepiléticos: mecanismos de ação e farmacocinética". In Epilepsia, conceitos, diagnóstico e tratamento, 179-204. Lidel, 2016. Publicado Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "Adenosine A2A Receptors and Neurotrophic Factors: Relevance for Parkinson’s Disease". In The Adenosinergic System. Current Topics in Neurotoxicity, editado por Morelli M.; Simola N.; Wardas J., 57-79. Springer International Publishing, 2015. Publicado • 10.1007/978-3-319-20273-0_4
Documento de trabalho	Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. 2021. "Astrocytic dn-SNARE expression prevents acute Aß effects in synaptic plasticity.".
Poster em conferência	Inteiro-Oliveira, Sara; Barreira-Fernandes, Lia; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "A virtual-aided design of small compounds to prevent BDNF receptor cleavage in Alzheimer’s disease". Trabalho apresentado em EPHAR2024, 2024. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, G; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori J; et al. "Loss Of Neuroprotection in Alzheimer's disease: Shedding Light on BDNF Receptor Cleavage And Its Mirroring In Extracellular Vesicles". 2024. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori, Juzoh; et al. "Mirroring of BDNF/TrkB Dysregulation On Brain Parenchyma and Plasma-derived Extracellular Vesicles from Alzheimer’s disease Patients". Trabalho apresentado em EpiC24, 2024. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori, Juzoh; et al. "BDNF/TrkB system dysregulation at the cell environment: extracellular vesicles as carriers of TrkB-ICD in Alzheimer’s disease". Trabalho apresentado em ISEV2024, 2024. Lourenço, M; Miguéis, M; Ianni, Marta; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Nuno Aleman-Serrano; et al. "Exploring miR-124 Key Role in the Interplay Between Autophagy and NLRP3 in the 5xFAD Mice". Trabalho apresentado em VIII Symposium of the Portuguese Glial Network, 2024. Inteiro-Oliveira, Sara; Barreira-Fernandes, Lia; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Small Compounds: a promising strategy to prevent TrkB-FL cleavage in Alzheimers Disease". Trabalho apresentado em EMBO Young Scientists Forum, 2023. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori, Juzoh; et al. "BDNF receptor dysregulation is mirrored in cerebrospinal fluid and plasma-derived extracellular vesicles from Alzheimer's disease patients". Trabalho apresentado em EMBO Young Scientists Forum 2023, 2023. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori, Juzoh; et al. "Brain-derived Neurotrophic Factor receptor: cleaved TrkB-FL C-terminal fragment is secreted extracellularly". Trabalho apresentado em SNEV Virtual Conference 2023: Everything Everywhere All About Extracellular Vesicles, 2023. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Umemori, Juzoh; Castrén, Eero; Sebastião, AM; Brites, Dora; Diógenes, MJ. "Extracellular release of a fragment derived from BDNF receptor cleavage". Trabalho apresentado em 2nd Meeting of the Portuguese Network of Extracellular Vesicles, 2023. Inteiro-Oliveira, Sara; Barreira-Fernandes, Lia; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Small Compounds: a new promising strategy to prevent BDNF receptor cleavage". Trabalho apresentado em 37ª Reunião Anual Grupo de Estudos de Envelhecimento Cerebral e Demência, 2023. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, G; Ferreira-Manso, Mafalda; Catarina B. Ferreira; de Almeida-Borlido, Carolina; Umemori J; et al. "Shedding light on BDNF/TRKB-FL system dysregulation in Alzheimer's disease". Trabalho apresentado em 37ª Reunião Anual do Grupo de Envelhecimento Cerebral e Demência (GEECD), 2023. Inteiro-Oliveira, Sara; Barreira-Fernandes, Lia; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Computational-aided design of small compounds to prevent TrkB-FL receptor cleavage". Trabalho apresentado em FENS Regional Meeting 2023, 2023. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Sebastião, AM; Brites, Dora; Diógenes, MJ. "Dysregulation of the BDNF/TrkB system in Alzheimer's disease ramifies in the secretion of a TrkB-derived fragment through extracellular vesicles". Trabalho apresentado em FENS Regional Meeting 2023, 2023. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Ferreira CB; de Almeida-Borlido, Carolina; Umemori J; et al. "Surveying TrkB-ICD secretion pathways and its presence in cerebrospinal fluid from Alzheimer's disease patients". 2023. Nuno Aleman-Serrano; Costa-Coelho, Tiago; Diógenes, MJ; Ana Maria Ferreira de Sousa Sebastião. "BDNF receptor cleavage in Alzheimer´s Disease: From mice to humans". Trabalho apresentado em 7.ª Conferência Anual da RedeSAÚDE, 2023. Nuno Aleman-Serrano; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Diógenes, MJ; Ana Maria Ferreira de Sousa Sebastião. "BDNF receptor cleavage across dementias: evaluating TrkB-ICD in human AD and FTD samples". Trabalho apresentado em 2nd Symposium on Alzheimer's Disease: An Update on Pathology and Therapeutics, 2023. Nuno Aleman-Serrano; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Diógenes, MJ; Ana Maria Ferreira de Sousa Sebastião. "BDNF signaling pathway disfunction across dementias: TrkB-ICD in human AD and FTD patient samples". Trabalho apresentado em FENS Regional Meeting, 2023. Nuno Aleman-Serrano; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Diógenes, MJ; Ana Maria Ferreira de Sousa Sebastião. "BDNF receptor dysfunction across dementias: evaluating TrkB-ICD in human AD and FTD patient samples". Trabalho apresentado em XXV Conference of Young SIF Pharmacologists Urbino, 2023. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Brites, Dora; Diógenes, MJ. "Insight on TrkB-FL cleavage as a potential biomarker in Alzheimer’s disease". Trabalho apresentado em 3rd Annual Meeting EpiEpiNet, 2022. Inteiro-Oliveira, Sara; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Virtual docking design of small compounds to prevent TrkB-FL receptor cleavage". Trabalho apresentado em 3rd Anual Meeting of Epileptogenesis and Epilepsy Network (EpiEpiNET), 2022. Barreira-Fernandes, Lia; Inteiro-Oliveira, Sara; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Analyzing new compounds in attempt to prevent TrkB-FL receptor cleavage". Trabalho apresentado em 4. 3rd Anual Meeting of Epileptogenesis and Epilepsy Network (EpiEpiNET), 2022. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Umemori J; Castrén E; Sebastião, AM; Brites, Dora; Diógenes, MJ. "Dysregulation Of Brain-Derived Neurotrophic Factor Receptor In Alzheimer's Disease Is Mirrored In Extracellular Vesicles". Trabalho apresentado em FENS Forum 2022, 2022. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Diógenes, MJ. "TrkB-FL Cleavage Promotes Release of Neuronal TrkB-ICD Within the Secretome of Cholinergic-like Cells in Alzheimer's disease". Trabalho apresentado em AIMS2022 Research Competition, 2022. Inteiro-Oliveira, Sara; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Computer-aided drug design of small compounds to prevent TrkB-FL receptor cleavage". Trabalho apresentado em AIMS research competition, 2022. Aleman Serrano, Nuno; Cardoso-Amaral, Rita; de Almeida-Borlido, Carolina; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Ribeiro-Rodrigues, Leonor; Sebastião, AM; Diógenes, MJ. Autor correspondente: Cardoso-Amaral, Rita. "A new key for unlocking Alzheimer's Disease". Trabalho apresentado em AIMS2022 Research Competition, 2022. Costa-Coelho, Tiago; Fonseca-Gomes, João; Garcia, Gonçalo; Ferreira-Manso, Mafalda; Umemori J; Castrén E; Sebastião, AM; Brites, Dora; Diógenes, MJ. "SH-SY5Y-derived extracellular vesicles drive the release of a Brain-derived Neurotrophic Factor receptor fragment: relevance for Alzheimer's disease". 2022. Inteiro-Oliveira, Sara; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Sebastião, AM; Enguita, Francisco J.; Diógenes, MJ. "Screening of small, non-peptide compounds to prevent TrkB-FL cleavage in Alzheimer´s disease". Trabalho apresentado em Portuguese Society for Neuroscience (SPN), 2021. Tiago Costa Coelho; Fonseca-Gomes, João; Garcia, G; Ferreira-Manso, Mafalda; Ana M. Sebastião; Brites, Dora; Diógenes, MJ. "SH-SY5Y-derived extracellular vesicles drive the release of a BDNF receptor fragment: Relevance for Alzheimer's disease". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Abreu DS; Gomes JI; Sottomayor MN; Ribeiro FF; Vicente Miranda, Hugo; Marques MC; Summavielle, Teresa; et al. "Astrocyte’s dysregulation: a central hub in Alzheimer’s disease pathophysiology?". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Ribeiro-Rodrigues, L; Fonseca-Gomes, João; Paulo, SL; Zavalko, S; Paiva, VH; Sebastião, AM; Diógenes, MJ; Xapelli, S. "TrkB-FL cleavage and anxiety-like behaviour is dependent on kainate-induced seizure severity". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN2021), 2021. Aleman Serrano, Nuno; Cardoso-Amaral, Rita; de Almeida-Borlido, Carolina; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Ribeiro-Rodrigues, Leonor; Sebastião, Ana M; Diógenes, MJ. Autor correspondente: Aleman Serrano, Nuno. "Therapeutic monitorization of TAT-TrkB effect in preventing BDNF (TrkB-FL) receptor cleavage in CSF and blood of animal model". Trabalho apresentado em 10ª Edição do Dia de Investigação - Science is Alive, 2021. Paulo, SL; Ribeiro-Rodrigues, L; Rodrigues, RS; Mateus, JM; Fonseca-Gomes, João; Soares, Rita; Diógenes, MJ; et al. "Mind the bias: lessons on the reproducibility of an amyloid-ß-induced Alzheimer’s disease model". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience (SPN2021), 2021. Ferreira-Manso, Mafalda; Fonseca-Gomes, João; Belo, Rita F.; Miranda-Lourenço, Catarina; Costa-Coelho, Tiago; Sebastião, AM; Fernandes, Adelaide; Diógenes, MJ. Autor correspondente: Ferreira-Manso, Mafalda. "TAT-TrkB, a novel peptide able to restore TrkB-FL levels and the learning curve of 5xFAD mice". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Abreu, Daniela; Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "Impact of astrocytes in neurotoxicity mediated by amyloid-ß: potential role of D-serine". Trabalho apresentado em AIMS Meeting – Annual International (bio)Medical Students Meeting, 2021. Nuno Aleman-Serrano; Costa-Coelho, Tiago; Miranda-Lourenço, Catarina; Diógenes, MJ; Ana Maria Ferreira de Sousa Sebastião. "Method optimization to evaluate TrkB-ICD in Cerebrospinal Fluid and Blood of mice". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal, 2021. Paulo, SL; Ribeiro-Rodrigues, L; Rodrigues, RS; Mateus, JM; Fonseca-Gomes, J; Diógenes, MJ; Solá, S; et al. "Adult hippocampal neurogenesis and amyloid-ß: reproducibility of a sporadic Alzheimer’s disease model". Trabalho apresentado em 12th FENS Forum of Neuroscience, 2020. 10.14293/S2199-1006.1.SOR-.PP5MOIH.v1 Gomes, J; Fonseca-Gomes, J; Vicente Miranda, H; Sebastião, AM; Diógenes, MJ; Vaz, SH; Gomes, JI. "On the role of astrocytes upon Aß-mediated neurotoxicity". Trabalho apresentado em 12th FENS Forum of Neuroscience, 2020. 10.3389/conf.fncel.2019.01.00023 Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "On the role of astrocytic signaling in Aß triggered synaptic deficits .". Trabalho apresentado em 12th FENS Forum of Neuroscience, Virtual Forum, 2020. Costa-Coelho, T; Fonseca-Gomes, J; Ferreira, CB; Sebastião, AM; Brites, D; Diógenes, MJ. "Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome/exosome signalling in Alzheimer’s disease". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2019. Ferreira, CB; Coelho, JE; Temido-Ferreira, M; Miranda-Lourenço, C; Fonseca-Gomes, J; Belo, RF; Tanqueiro, SR; et al. "Role of SEPT5 overexpression on synaptic function and its dependency on S327 phosphorylation". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2019. Ferreira-Manso, M; Fonseca-Gomes, J; Miranda-Lourenço, C; Ribeiro, FF; Xapelli, S; Sebastião, AM; Fernandes, A; Diógenes, MJ. "The impact of BDNF receptor cleavage in Alzheimer’s disease-associated Neuroinflammation". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2019. Freitas, CF; Tanqueiro, SR; Sebastião, AM; Dawson, N; Diógenes, MJ. "Characterization of BDNF signalling in the prefrontal cortex in the neonatal phencyclidine mouse model of schizophrenia". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2019. Paulo, SL; Ribeiro-Rodrigues, L; Rodrigues, RS; Mateus, JM; Soares, R.; Fonseca-Gomes, J; Diógenes, MJ; et al. "Look before you leap: a perspective on the reproducibility of a sporadic Alzheimer’s disease model and its impact on neurogenesis". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2019. Ribeiro-Rodrigues, L; Fonseca-Gomes, J; Sebastião, AM; Xapelli, S; Diógenes, MJ. "Interaction between BDNF/TrkB signaling and neurogenesis in epilepsy - The basis for the project". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2019. Zavalko, S; Mouro, FM; Lourenço, DM; Miranda-Lourenço, C; Sebastião, AM; Diógenes, MJ; Xapelli, S. "Cannabinoid actions on Rett Syndrome’s associated deficits and its effect on post-natal Neurogenesis in a female MECP2-mutant mouse model". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2019. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "The role of tripartite synapse upon Aß-mediated synaptic deficits". Trabalho apresentado em 5th PhD Students Meeting of Mind-Brain College of Universidade de Lisboa, 2019. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "The role of astrocytic signaling upon Aß-induced synaptic deficits.". Trabalho apresentado em AstraZeneca Foundation Innovate Competition, iMed Conference ® 11.0, 2019. Fonseca-Gomes, J; Vaz, SH; Rodrigues, TM; Jerónimo-Santos, A; Belo, RF; Mäkinen, P; Takalo, M; et al. "Prevention of BDNF receptor cleavage as a therapeutic strategy for Alzheimer’s disease pathophysiology". Trabalho apresentado em Gordon Research Conference on Neurotrophic Mechanisms in Health and Disease, Newport, Rhode Island, Estados Unidos, 2019. Tanqueiro, SR; Almeida-Silva, G; Mouro, FM; Sebastião, AM; Simões do Couto, F; Dawson, N; Diógenes, MJ. "BDNF loss of function in the prefrontal cortex may underlie cognitive deficits in the subchronic phencyclidine model of schizophrenia". Trabalho apresentado em Gordon Research Conference on Neurotrophic Mechanisms in Health and Disease, Newport, Rhode Island, Estados Unidos, 2019. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "Astrocytic signaling upon Aß-mediated excitotoxicity.". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019. Belo, RF; Fonseca-Gomes, J; Vicente Miranda, H; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "The neuroprotective effect Amidated-Kyotorphin on Alzheimer’s Disease". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, Portugal, 2019. Ferreira, CB; Coelho, JE; Temido-Ferreira, M; Miranda-Lourenço, C; Fonseca-Gomes, J; Belo, RF; Tanqueiro, SR; et al. "SEPT5 phosphorylation status: importance for synaptic function and mice behavior performance". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, Portugal, 2019. Enguita, FJ; Fonseca-Gomes, J; Roque, M; Sebastião, AM; Diógenes, MJ. "Analysis of the transcriptomic response induced by the intracellular domain (TrkB-ICD) of TrkB receptor in rat cortical neurons". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, Portugal, 2019. Mouro, FM; Fonseca-Gomes, J; Miranda-Lourenço, C; Sebastião, AM; Diógenes, MJ. "Molecular evaluation of the endocannabinoid system in RTT mice-model: implications for cannabinoid-based treatments". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, Portugal, 2019. Tanqueiro, SR; Almeida-Silva, G; Mouro, FM; Sebastião, AM; Simões do Couto, F; Dawson, N; Diógenes, MJ. "Does BDNF loss of function in the prefrontal cortex underlie cognitive deficits in the subchronic phencyclidine model of schizophrenia?". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, Portugal, 2019. Gomes, Joana I.; Fonseca-Gomes, João; Vicente Miranda, Hugo; Sebastião, AM; Diógenes, MJ; Vaz, Sandra H.. "The role of astrocytic signaling on AD-like conditions.". Trabalho apresentado em IV Symposium of the Portuguese Glial Network: Glia Diversity in Neuromodulation and Neurodegeneration, 2019. Ferreira, CB; Coelho, JE; Temido-Ferreira, M; Miranda-Lourenço, M; Fonseca-Gomes, J; Belo, RF; Tanqueiro, SR; et al. "Unveiling the effect of SEPT5 on synaptic function". Trabalho apresentado em XIII CAML PhD Student’s Meeting, Lisboa, Portugal, 2019. Miranda-Lourenço, C; Rosa, J; Palminha, C; Duarte, ST; Colino-Oliveira, M; Gomes, R.; Rodrigues, TM; et al. "Adenosine augmentation therapy as a possible strategy for Rett Syndrome". Trabalho apresentado em XIII CAML PhD Student’s Meeting, Lisboa, Portugal, 2019. Tanqueiro, SR; Almeida-Silva, G; Mouro, FM; Duarte, TA; Deveza, MM; Sebastião, AM; Simões do Couto, F; Dawson, N; Diógenes, MJ. "Interplay between BDNF signalling and cognitive alterations in the subchronic phencyclidine model of schizophrenia". Trabalho apresentado em XIII CAML PhD Student’s Meeting, Lisboa, Portugal, 2019. Belo, RF; Fonseca-Gomes, J; Vicente Miranda, H; Outeiro, TF; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "Amidated-Kyotorphin neuroprotective effect on Alzheimer’s Disease". Trabalho apresentado em 14th International Conference on Alzheimer’s & Parkinson’s diseases, Lisboa, Portugal, 2019. Ferreira, CB; Paldanius, KA; Mäkinen, P; Sebastião, AM; de Mendonça, A; Diógenes, MJ; Hiltunen, M. "Unveiling the role of SEPT5 in APP processing and on Aß peptide production in vitro". Trabalho apresentado em 14th International Conference on Alzheimer’s & Parkinson’s diseases, Lisboa, Portugal, 2019. Belo, RF; Fonseca-Gomes, J; Vicente Miranda, H; Outeiro, TF; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "The neuroprotective role of Amidated-kyotorphin on Alzheimer’s Disease". Trabalho apresentado em 3rd Annual Scientific Meeting of the SynaNet, Lisboa, Portugal, 2018. Ferreira, CB; Kaisa, M; Paldanius, A; Mäkinen, P; Sebastião, AM; de Mendonça, A; Diógenes, MJ; Hiltunen, M. "Unveilling the effect of SEPT5 in APP processing and Aß generation". Trabalho apresentado em 3rd Annual Scientific Meeting of the SynaNet, Lisboa, Portugal, 2018. Gomes, JI; Fonseca-Gomes, J; Vicente Miranda, H; Sebastião, AM; Diógenes, MJ; Vaz, SH. "Role of astrocytes upon amyloid-ß (Aß) neurotoxic pathways". Trabalho apresentado em 3rd Annual Scientific Meeting of the SynaNet, Lisboa, Portugal, 2018. Miranda-Lourenço, C; Palminha, C; Rosa, J; Fonseca-Gomes, J; Vaz, SH; Sebastião, AM; Diógenes, MJ. "Neuronal excitability deregulation on Rett Syndrome". Trabalho apresentado em 3rd Annual Scientific Meeting of the SynaNet, Lisboa, Portugal, 2018. Rosa, J; Miranda-Lourenço, C; Sebastião, AM; Diógenes, MJ. "Adenosinergic system on BDNF mediated signalling in heterozygous female of a Rett syndrome mouse model". Trabalho apresentado em 3rd Annual Scientific Meeting of the SynaNet, Lisboa, Portugal, 2018. Paulo, SL; Miranda-Lourenço, C; Belo, RF; Rodrigues, RS; Tanqueiro, SR; Fonseca-Gomes, J; Sebastião, AM; Xapelli, S; Diógenes, MJ. "High sugar intake during aging: consequences for synaptic plasticity and rat behaviour performance". Trabalho apresentado em SynaNet H2020 – 3rd Annual Scientific Meeting (Lisboa, Portugal), 2018. Gomes, JI; Fonseca-Gomes, J; Vicente Miranda, H; Sebastião, AM; Diógenes, MJ; Vaz, SH. "Role of SNARE-dependent gliotransmitters release from astrocytes upon amyloid-ß mediated neurotoxicity". Trabalho apresentado em 4th PhD Students Meeting of the Mind-Brain College, Lisboa, Portugal, 2018. Miranda-Lourenço, C; Palminha, C; Rosa, J; Fonseca-Gomes, J; Vaz, SH; Sebastião, AM; Diógenes, MJ. "Study of the hyperexcitability in hippocampus of Mecp2 KO mice". Trabalho apresentado em 4th Students Meeting of the Mind-Brain College, Lisboa, Portugal, 2018. Paulo, SL; Miranda-Lourenço, C; Belo, RF; Rodrigues, RS; Tanqueiro, SR; Fonseca-Gomes, J; Gonçalves-Rosa, N; et al. "Impact of a high sugar diet during rat aging on synaptic plasticity, hippocampal neurogenesis and behaviour performance". Trabalho apresentado em 4th Students Meeting of the Mind-Brain College, Lisboa, Portugal, 2018. Rosa, J; Miranda-Lourenço, C; Sebastião, AM; Diógenes, MJ. "Adenosinergic system and BDNF signalling in heterozygous females of the Mecp2 mice model". Trabalho apresentado em 4th Students Meeting of the Mind-Brain College, Lisboa, Portugal, 2018. Belo, RF; Fonseca-Gomes, J; Vicente Miranda, H; Outeiro, TF; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "The neuroprotective role of Amidated-Kyotorphin on Alzheimer’s Disease pathophysiology". Trabalho apresentado em 48th Annual Meeting of the Society for Neuroscience, San Diego, USA, 2018. Ferreira, CB; Kaisa, M; Paldanius, A; Mäkinen, P; Sebastião, AM; de Mendonça, A; Diógenes, MJ; Hiltunen, M. "Role of SEPT5 in the molecular pathogenesis of Alzheimer’s disease". Trabalho apresentado em 48th Annual Meeting of the Society for Neuroscience, San Diego, USA, 2018. Fonseca-Gomes, J; Jerónimo-Santos, A; Belo, RF; Vaz, SH; Rodrigues, TM; Marttinen, M; Mäkinen, P; et al. "BDNF receptor cleavage in Alzheimer’s disease: quantification in human brain samples and molecular consequences". Trabalho apresentado em 48th Annual Meeting of the Society for Neuroscience, San Diego, USA, 2018. Miranda-Lourenço, C; Palminha, C; Duarte, ST; Gaspar, C; Colino-Oliveira, M; Rosa, J; Gomes, R.; et al. "Adenosinergic system dysfunction in Rett Syndrome". Trabalho apresentado em 48th Annual Meeting of the Society for Neuroscience, San Diego, USA, 2018. Rosa, J; Miranda-Lourenço, C; Sebastião, AM; Diógenes, MJ. "Characterization of the adenosinergic system and the BDNF-mediated signaling in heterozygous females of a Rett syndrome model". Trabalho apresentado em 48th Annual Meeting of the Society for Neuroscience, San Diego, USA, 2018. Tanqueiro, SR; Almeida-Silva, G; Mouro, FM; Dawson, N; Sebastião, AM; Diógenes, MJ. "Interplay between the loss of BDNF signalling and cognitive dysfunction in the subchronic phencyclidine model of schizophrenia". Trabalho apresentado em 48th Annual Meeting of the Society for Neuroscience, San Diego, USA, 2018. Paulo, SL; Miranda-Lourenço, C; Belo, RF; Rodrigues, RS; Tanqueiro, SR; Fonseca-Gomes, J; Sebastião, AM; Xapelli, S; Diógenes, MJ. "Impact of a high sugar diet during rat aging on synaptic plasticity, hippocampal neurogenesis and behaviour performance (pitch and poster presentation)". Trabalho apresentado em 4th Meeting of the PhD Students from the Mind-Brain College of the University of Lisbon (Lisboa, Portugal), 2018. Ferreira, CB; Kaisa, M; Paldanius, A; Mäkinen, P; Sebastião, AM; de Mendonça, A; Diógenes, MJ; Hiltunen, M. "Unveiling the effect of SEPT5 in amyloid cascade". Trabalho apresentado em 32ª Reunião do Grupo de Estudos de Envelhecimento e Demência (GEECD), Lisboa, Portugal, 2018. Diógenes, MJ; Belo, RF; Fonseca-Gomes, J; Vaz, SH; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "The effects of exercise on different types of neurotrophins and brain function". Trabalho apresentado em 11th FENS Forum of Neuroscience, Berlim, Alemanha, 2018. Ferreira, CB; Kaisa, M; Paldanius, A; Mäkinen, P; Sebastião, AM; de Mendonça, A; Diógenes, MJ; Hiltunen, M. "Elucidation of SEPT5 in APP processing and Aß peptide production in vitro". Trabalho apresentado em 11th FENS Forum of Neuroscience, Berlim, Alemanha, 2018. Fonseca-Gomes, J; Jerónimo-Santos, A; Belo, RF; Vaz, SH; Rodrigues, TM; Marttinen, M; Mäkinen, P; et al. "Detection of BDNF receptor cleavage in Alzheimer’s disease human brain samples and development of a novel therapeutic strategy". Trabalho apresentado em 11th FENS Forum of Neuroscience, Berlim, Alemanha, 2018. Paulo, SL; Rodrigues, RS; Ribeiro, FF; Fonseca-Gomes, J; Shvachiy, L; Coelho, JE; Diógenes, MJ; et al. "Aß1-42 peptide intracerebroventricular injection in rat behaviour and hippocampal neurogenesis". Trabalho apresentado em 11th FENS Forum of Neuroscience, Berlim, Alemanha, 2018. Tanqueiro, SR; Almeida-Silva, G; Dawson, N; Sebastião, AM; Diógenes, MJ. "Interplay between the loss of BDNF signalling and cognitive dysfunction in schizophrenia: insights from the subchronic phencyclidine model". Trabalho apresentado em 11th FENS Forum of Neuroscience, Berlim, Alemanha, 2018. Belo, RF; Fonseca-Gomes, J; Vicente Miranda, H; Outeiro, TF; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "Amidated-Kyotorphin as a neuroprotective drug for Alzheimer’s Disease". Trabalho apresentado em 8th Kuopio Alzheimer Symposium, Kuopio, Finland, 2018. Ferreira, CB; Kaisa, M; Paldanius, A; Mäkinen, P; Sebastião, AM; de Mendonça, A; Diógenes, MJ; Hiltunen, M. "Role of SEPT5 in the APP processing in SH-SY5Y-APP751 neuroblastoma cells". Trabalho apresentado em 8th Kuopio Alzheimer Symposium, Kuopio, Finland, 2018. Fonseca-Gomes, J; Jerónimo-Santos, A; Belo, RF; Vaz, SH; Rodrigues, TM; Marttinen, M; Mäkinen, P; et al. "Novel therapeutic strategy to prevent the loss of BDNF signaling in Alzheimer´s Disease". Trabalho apresentado em 8th Kuopio Alzheimer Symposium, Kuopio, Finland, 2018. Belo, RF; Fonseca-Gomes, J; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "Neuroprotective effect of amidated-Kyotorphin". Trabalho apresentado em XII CAML PhD Student’s Meeting, Lisboa, Portugal, 2018. Tanqueiro, SR; Dawson, N; Sebastião, AM; Diógenes, MJ. "Scrutinizing the relationship between BDNF signalling impairments and cognitive dysfunction in an animal model of schizophrenia". Trabalho apresentado em XII CAML PhD Student’s Meeting, Lisboa, Portugal, 2018. Fonseca-Gomes, J; Belo, R; Vaz, Sandra H.; Rodrigues, TM; Manso, N; Mäkinen, P; Takalo, M; et al. "BDNF receptor cleavage: detection in Alzheimer’s disease human brain samples and development of a novel therapeutic strategy". Trabalho apresentado em XII iMM PhD Student meeting, 2018. Belo, RF; Gomes, JI; Vaz, SH; Perez-Peinado, C; Valle, J; Andreu, D; Sebastião, AM; et al. "Deciphering the effects of Kyotorphin on the brain". Trabalho apresentado em 2nd Annual Scientific Meeting of the Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet), Lisboa, Portugal, 2018. Ferreira, CB; Kaisa, M; Paldanius, A; Mäkinen, P; Sebastião, AM; de Mendonça, A; Diógenes, MJ; Hiltunen, M. "Role of SEPT5 in the APP processing and Aß peptide production in SH-SY5Y-APP751 neuroblastoma cells". Trabalho apresentado em 2nd Annual Scientific Meeting of the Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet), Lisboa, Portugal, 2018. Fonseca-Gomes, J; Vaz, SH; Rodrigues, TM; Marttinen, M; Mäkinen, P; Takalo, M; Haapasalo, A; et al. "Identification of traces of BDNF receptor cleavage in Alzheimer’s Disease human brain samples and development of a novel therapeutic strategy". Trabalho apresentado em 2nd Annual Scientific Meeting of the Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet), Lisboa, Portugal, 2018. Miranda-Lourenço, C; Ferreira, S.; Sebastião, AM; Diógenes, MJ. "TrkB receptors and Adenosine Kinase changes in Mecp2 KO mouse brain". Trabalho apresentado em 2nd Annual Scientific Meeting of the Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet), Lisboa, Portugal, 2018. Paulo, SL; Rodrigues, RS; Ribeiro, FF; Fonseca-Gomes, J; Shvachiy, L; Coelho, JE; Diógenes, MJ; et al. "Effect of an intracerebroventricular injection of Aß1-42 peptide on adult hippocampal neurogenesis". Trabalho apresentado em 2nd Annual Scientific Meeting of the Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet), Lisboa, Portugal, 2018. Tanqueiro, SR; Dawson, N; Sebastião, AM; Diógenes, MJ. "BDNF signaling and adenosinergic system alterations in a mice model of schizophrenia". Trabalho apresentado em 2nd Annual Scientific Meeting of the Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet), Lisboa, Portugal, 2018. Miranda-Lourenço, C; Palminha, C; Duarte, ST; Gaspar, C; Colino-Oliveira, M; Gomes, R; Ferreira, S.; et al. "Adenosinergic system as a new central player in Rett Syndrome". Trabalho apresentado em 5th European Rett Syndrome Congress 2017, Berlim, Alemanha, 2017. Belo, RF; Perez-Peinado, C; Valle, J; Andreu, D; Sebastião, AM; Castanho, M; Neves, V; Diógenes, MJ. "On the road of KTP and KTP-NH2 neuronal mechanisms of action". Trabalho apresentado em 3rd Students Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2017. Fonseca-Gomes, J; Jerónimo-Santos, A; Rodrigues, TM; Vaz, SH; Manso, N; Belo, RF; Sebastião, AM; Diógenes, MJ. "Protection of BDNF receptor cleavage: a possible new therapeutic strategy for Alzheimer’s Disease". Trabalho apresentado em 3rd Students Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2017. Miranda-Lourenço, C; Sebastião, AM; Diógenes, MJ. "BDNF signalling and Adenosinergic system in Rett Syndrome". Trabalho apresentado em 3rd Students Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2017. Tanqueiro, SR; Dawson, N; Sebastião, AM; Diógenes, MJ. "Deregulation of BDNF signaling in a mice model of schizophrenia". Trabalho apresentado em 3rd Students Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2017. Fonseca-Gomes, J; Jerónimo-Santos, A; Rodrigues, TM; Vaz, SH; Sebastião, AM; Diógenes, MJ. "Protection of BDNF receptor cleavage as a possible therapeutic strategy for Alzheimer’s Disease". Trabalho apresentado em Alzheimer's Global Summit Lisbon 2017, Lisboa, Portugal, 2017. Belo, RF; Neves, V; Castanho, M; Sebastião, AM; Diógenes, MJ. "Exploring Kyotorphin and Amidated-Kyotorphin actions upon synaptic transmission and plasticity, and on calpains and caspases activation". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 2017. Fonseca-Gomes, J; Jerónimo-Santos, A; Sebastião, AM; Diógenes, MJ. "Impact of BDNF receptor cleavage on Alzheimer’s Disease pathophysiology". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 2017. Miranda-Lourenço, C; Ferreira, S.; Sebastião, AM; Diógenes, MJ. "Characterization of BDNF signalling and adenosinergic system in Rett Syndrome". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 2017. Tanqueiro, SR; Ramalho, RM; Sebastião, AM; Diógenes, MJ. "Amyloid ß induces BDNF loss of function by a mechanism dependent on Extrasynaptic NMDA receptors activation". Trabalho apresentado em XV Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 2017. Belo, RF; Neves, V; Castanho, M; Sebastião, AM; Diógenes, MJ. "Kyotorphin and amidated-kyotorphin effects on hippocampal synaptic transmission and on calpains and caspases activation". Trabalho apresentado em XI CAML PhD Student’s Meeting, Lisboa, Portugal, 2017. Fonseca-Gomes, J; Jerónimo-Santos, A; Sebastião, AM; Diógenes, MJ. "Prevention of BDNF receptor cleavage on Alzheimer’s Disease pathophysiology". Trabalho apresentado em XI CAML PhD Student’s Meeting, Lisboa, Portugal, 2017. Miranda-Lourenço, C; Ferreira, S.; Sebastião, AM; Diógenes, MJ. "Changes in Brain-derived neurotrophic factor and adenosinergic system in Mecp2 knockout mouse model". Trabalho apresentado em XI CAML PhD Student’s Meeting, Lisboa, Portugal, 2017. Belo, RF; Neves, V; Castanho, M; Sebastião, AM; Diógenes, MJ. "Exploring Kyotorphin and Amidated-kyotorphin actions: synaptic transmission and calpains and caspases activation". Trabalho apresentado em 4 th Annual Conference of redeSAÚDE, Lisboa, Portugal, 2017. Fonseca-Gomes, J; Jerónimo-Santos, A; Sebastião, AM; Diógenes, MJ. "Relevance of BDNF receptor cleavage on Alzheimer’s Disease pathophysiology". Trabalho apresentado em 4 th Annual Conference of redeSAÚDE, Lisboa, Portugal, 2017. Miranda-Lourenço, C; Ferreira, S.; Sebastião, AM; Diógenes, MJ. "Brain-derived neurotrophic factor signalling and adenosinergic system in Mecp2 knockout mouse model". Trabalho apresentado em 4 th Annual Conference of redeSAÚDE, Lisboa, Portugal, 2017. Belo, RF; Neves, V; Sebastião, AM; Diógenes, MJ. "Kyotorphin and amidated-kyotorphin effects on hippocampal synaptic transmission and on calpains and caspases activation". Trabalho apresentado em First Annual Scientific Meeting of the SynaNet Project, Lisboa, Portugal, 2017. Fonseca-Gomes, J; Jerónimo-Santos, A; Sebastião, AM; Diógenes, MJ. "Prevention of BDNF receptor cleavage: future perspectives about its possible application as therapeutic tool". Trabalho apresentado em First Annual Scientific Meeting of the SynaNet Project, Lisboa, Portugal, 2017. Miranda-Lourenço, C; Ferreira, S.; Sebastião, AM; Diógenes, MJ. "Rett Syndrome: BDNF signalling and Adenosinergic system changes". Trabalho apresentado em First Annual Scientific Meeting of the SynaNet Project, Lisboa, Portugal, 2017. Tanqueiro, SR; Ramalho, RM; Sebastião, AM; Diógenes, MJ. "Amyloid ß induces BDNF loss of function by a mechanism dependent on Extrasynaptic NMDA receptors activation". Trabalho apresentado em First Annual Scientific Meeting of the SynaNet Project, Lisboa, Portugal, 2017. Diógenes, MJ; Tanqueiro, SR; Ramalho, RM; Sebastião, AM; Diógenes, MJ. "Amyloid ß induces BDNF loss of function by a mechanism dependent on Extrasynaptic NMDA receptors activation". Trabalho apresentado em 2nd students Meeting of Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2016. Belo, RF; Neves, V.; Sebastião, AM; Diógenes, MJ. "Kyotorphin: a new possible pharmacological treatment for Alzheimer's disease?". Trabalho apresentado em 2nd students Meeting of Mind-Brain College of the University of Lisbon, Lisboa, Portugal, 2016. Fonseca-Gomes, J; Jerónimo-Santos, A; Sebastião, AM; Diógenes, MJ. "Characterization of the newly discovered TrkB receptor fragment formed in the presence of amyloid beta peptide". Trabalho apresentado em 10th FENS Forum of Neuroscience, Copenhaga, Dinamarca, 2016. Miranda-Lourenço, C; Palminha, C; Duarte, ST; Gaspar, C; Colino-Oliveira, M; Gomes, R; Ferreira, S.; et al. "Dysregulation of adenosinergic system in Rett Syndrome". Trabalho apresentado em 10th FENS Forum of Neuroscience, Copenhaga, Dinamarca., 2016. Vaz, Sandra H.; de Castro-Abrantes, M; Morin, S; Avelar, P; Diógenes, MJ; Sebastião, Ana M. "Adenosine A1 and A2A receptors modulate mGluR5-mediated calcium signalling in rat cortical primary astrocytes". Trabalho apresentado em 10th Forum of European Neuroscience, 2016. Fonseca-Gomes, J; Jerónimo-Santos, A; Sebastião, AM; Diógenes, MJ. "Characterization of the newly discovered TrkB receptor fragment (TrkB-ICD) formed by calpain cleavage". Trabalho apresentado em 1º Encontro de estudantes Colégio Doutoral Mente-Cérebro da Universidade de Lisboa, Lisboa, Portugal, 2015. Miranda-Lourenço, C; Palminha, C; Duarte, ST; Gaspar, C; Colino-Oliveira, M; Gomes, R; Ferreira, S.; et al. "Characterization of adenosinergic system in Rett Syndrome". Trabalho apresentado em 1º Encontro de estudantes Colégio Doutoral Mente-Cérebro da Universidade de Lisboa, Lisboa, Portugal, 2015. Tanqueiro, SR; Ramalho, RM; Sebastião, AM; Diógenes, MJ. "Deciphering the mechanisms underlying the loss of BDNF neuroprotection in an Alzheimer’s Disease model". Trabalho apresentado em 1º Encontro de estudantes Colégio Doutoral Mente-Cérebro da Universidade de Lisboa, Lisboa, Portugal, 2015. Ramalho, RM; Tanqueiro, SR; Sebastião, AM; Diógenes, MJ. "Restoring the protective function of BDNF in Alzheimer's disease". Trabalho apresentado em 3rd IMM Postdoc Day Meeting, Lisboa, Portugal, 2015. Jerónimo-Santos, A; Vaz, Sandra H.; Buée-Scherrer, V; Castrén, E; Valente, CA; Blum, D; Sebastião, Ana M; Diógenes, MJ. "Amyloid-ß Peptide dysregulation TrkB Receptors and BDNF Function by a Calpain-dependent mechanism". Trabalho apresentado em 9th Forum of European Neuroscience, 2014. Diógenes, MJ; Jerónimo-Santos, A; Batalha, VL; Muller, C; Hockemeyer, J; Lopes, LV; Sebastião, AM. "Chronic blockade of adenosine A2A receptors prevents BDNF effect on hippocampal LTP". Trabalho apresentado em 9th FENS Forum of Neuroscience, Milão, Itália, 2014. Duarte, ST; Palminha, C; Rodrigues, TM; Ferreira, S.; Sebastião, AM; Diógenes, MJ. "Adenosine receptors as new pharmacological targets for Rett syndrom treatment". Trabalho apresentado em 9th FENS Forum of Neuroscience, Milão, Itália, 2014. Jerónimo-Santos, A; Vaz, SH; Parreira, S; Lérias, SR; Caetano, AP; Buée-Scherrer, V; Castrén, E; et al. "Amyloid-ß peptide dysregulates TrkB receptors and BDNF function by a calpain-dependent mechanism". Trabalho apresentado em 9th FENS Forum of Neuroscience, Milão, Itália, 2014. Jerónimo-Santos, A; Vaz, SH; Parreira, S; Lérias, SR; Caetano, AP; Buée-Scherrer, V; Castrén, E; et al. "Amyloid-ß peptide dysregulates TrkB receptors and BDNF function by a calpain-dependent mechanism". Trabalho apresentado em Molecular Biology in Portugal and EMBL (and EMBL Alumni), Lisboa, Portugal, 2013. Caetano, AP; Jerónimo-Santos, A; Vicente Miranda, H; Outeiro, TF; Sebastião, AM; Diógenes, MJ. "Unravelling the effect of differente Abeta species on BDNF effects upon hippocampal synaptic plasticity". Trabalho apresentado em XIII Meeting of the Portuguese Society for Neuroscience, Luso, Portugal, 2013. Covita, J; Rombo, D; Dias, RB; Sebastião, AM; Diógenes, MJ. "Effect of BDNF on synaptic and extrasynaptic NMDA currents". Trabalho apresentado em XIII Meeting of the Portuguese Society for Neuroscience, Luso, Portugal, 2013. Duque do Vale, R; Pinho, J; Lopes, LV; Ribeiro, JA; Sebastião, AM; de Mendonça, A; Diógenes, MJ. "LTP paradoxical increase upon ageing is due to NMDA receptor overactivation". Trabalho apresentado em 7th Young European Scientist Meeting, Porto, Portugal, 2012. Parreira, S; Lérias, SR; Vaz, SH; Diógenes, MJ; Sebastião, AM. "Effect of long exposure to amyloid-ß peptides in GABA release from hippocampal synaptosomes and its relevance for BDNF effects". Trabalho apresentado em 7th Young European Scientist Meeting, Porto, Portugal, 2012. Diógenes, MJ. "Compensatory LTP mediated by BDNF in aged animals". Trabalho apresentado em NGF Meeting, Wurzburg, Alemanha, 2012. Jerónimo-Santos, A; Valente, CA; Blum, D; Buée-Scherrer, V; Castrén, E; Sebastião, AM; Diógenes, MJ. "Amyloid-beta induces calpain-mediated cleavage of TrkB receptor". Trabalho apresentado em NGF Meeting, Wurzburg, Alemanha, 2012. Jerónimo-Santos, A; Valente, CA; Blum, D; Buée-Scherrer, V; Castrén, E; Sebastião, AM; Diógenes, MJ. "Amyloid-beta induces calpain-mediated cleavage of BDNF TrkB-FL receptor". Trabalho apresentado em 8th FENS Forum of Neuroscience, Barcelona, Espanha, 2012. Rodrigues, TM; Sebastião, AM; Diógenes, MJ. "Modulation of Long-Term Depression (LTD) by Brain-Derived Neurotrophic Factor (BDNF) and its interplay with Adenosine A2A Receptors". Trabalho apresentado em GAPIC Fifteenth Workshop for Science, FMUL, Lisboa, Portugal, 2012. Guerreiro, C; Ferreira, C; Vaz, Sandra H.; Diógenes, MJ; Ribeiro, JA; Sebastião, Ana M. "Modulation of BDNF effect on glutamate release in synaptosomes by amyloid peptide". Trabalho apresentado em VI Young European Scientist Meeting (YES Meeting), 2011. Brites, D; Silva, SL; Oliveira, A; Vaz, AR; Diógenes, MJ; van Rooijen, N; Sebastião, AM; et al. "Microglia faces featuring a potential pathological neural/glial behavior highly common in neonatal life". Trabalho apresentado em 10th European Meeting on Glial Cells in Health and Diseases, Praga, República Checa, 2011. Jerónimo-Santos, A; Batalha, VL; Muller, C; Hockemeyer, J; Sebastião, AM; Lopes, LV; Diógenes, MJ. "Chronic blockade of adenosine A2A receptors prevents BDNF effect on hippocampal LTP". Trabalho apresentado em XII Meeting of the Portuguese Society for Neuroscience, Lisboa, Portugal, 2011. Pinho, JS; Batalha, VL; Valadas, J; Constela, AR; Sebastião, AM; Lopes, LV; de Mendonça, A; Diógenes, MJ. "NMDA receptor blockade in ageing: impact on hippocampal dependent memory". Trabalho apresentado em XII Meeting of the Portuguese Society for Neuroscience, Lisboa, Portugal, 2011. Valadas, JS; Batalha, VL; Diógenes, MJ; Sebastião, AM; Lopes, LV. "Corticotrophin-releasing factor (CRF) receptors differentially influence the neuroprotective effective of A2A receptor blockade". Trabalho apresentado em XII Meeting of the Portuguese Society for Neuroscience, Lisboa, Portugal, 2011. Diógenes, MJ; Costenla, AR; Lopes, LV; Jerónimo-Santos, A; Sousa, VC; Fontinha, BM; Ribeiro, JA; Sebastião, AM. "Enhanced LTP in ageing is dependent on endogenous BDNF". Trabalho apresentado em Champalimaud Neuroscience Symposium, Lisboa, Portugal, 2011. Duque do Vale, R; Lopes, LV; Ribeiro, JA; Sebastião, AM; de Mendonça, A; Diógenes, MJ. "Detailing the age-related effects of memantine on long-term potentiation". Trabalho apresentado em 5th Young European Scientist Meeting, Porto, Portugal, 2010. Jerónimo-Santos, A; Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "Amyloid-beta induces changes in TrkB receptors expression: consequences for loss of neuroprotection by BDNF?". Trabalho apresentado em 7th FENS Forum of Neuroscience, Amesterdão, Países Baixos, 2010. Sebastião, AM; Neves-Tomé, R; Diógenes, MJ; Frenguelli, B; Boison, D; Ribeiro, JA. "Adenosine kinase activity determines tonic activation of adenosine receptors to trigger BDNF modulation of synaptic transmission". Trabalho apresentado em 7th FENS Forum of Neuroscience, Amesterdão, Países Baixos., 2010. Diógenes, MJ; Costenla, AR; Fontinha, BM; Ribeiro, JA; Sebastião, AM. "Effect of BDNF upon LTP in aging: influence of adenosine A2A receptors". Trabalho apresentado em 39th Annual Meeting of the Society for Neuroscience, Chicago, Estados Unidos, 2009. Diógenes, MJ; Costenla, AR; Fontinha, BM; Ribeiro, JA; Sebastião, AM. "Exogenous and endogenous BDNF effects upon LTP in aging". Trabalho apresentado em X Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 2009. Jerónimo, AS; Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "BDNF effects upon apoptosis induced by amyloid-beta peptide: changes in TrkB receptors expression". Trabalho apresentado em X Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 2009. Diógenes, MJ; Costenla, AR; Fontinha, BM; Ribeiro, JA; Sebastião, AM. "Influence of age on BDNF Modulation of Long term potentiation: interplay with adenosine A2A receptors". Trabalho apresentado em 6th FENS Forum of Neuroscience, Genebra, Suiça, 2008. Moura, B; Diógenes, MJ; Fernandes, CC; Pinto-Duarte, A; Solá, S; Rodrigues, CMP; Ribeiro, JA; Sebastião, AM. "BDNF potentiation mechanism induced by adenosine and impact on apoptosis". Trabalho apresentado em 2nd Young European Scientist Meeting, Porto, Portugal, 2007. Diógenes, MJ; Fontinha, BM; Costenla, AR; Ribeiro, JA; Sebastião, AM. "Age-related modulation of long-term potentiation (LTP) by brain-derived neurotrophic factor (BDNF)". Trabalho apresentado em X Reunião Anual da Sociedade Portuguesa de Farmacologia, Ofir, Portugal, 2007. Diógenes, MJ; Sebastião, AM; Ribeiro, JA. "The brain-derived neurotrophic factor (BDNF) facilitates synaptic transmission in adult rats in a long-term potentiation (LTP) “like” process". Trabalho apresentado em 5th FENS Forum of Neuroscience, Vienna, Austria, 2006. Pousinha, PA; Diógenes, MJ; Sebastião, AM; Ribeiro, JA. "The activation of adenosine A2A receptor influences BDNF effects on synaptic transmission at the rat diaphragm neuromuscular junction". Trabalho apresentado em IX Reunião Anual da Sociedade Portuguesa de Farmacologia, Luso, Portugal, 2005. Diógenes, MJ; Sebastião, AM; Ribeiro, JA. "Age-related changes in the cross-talk between BDNF and adenosine A2A receptors". Trabalho apresentado em 35th Annual Meeting of the Society for Neuroscience, Washington, Estados Unidos, 2005. Diógenes, MJ; Sebastião, AM; Ribeiro, JA. "Endogenous A2A receptor activation triggers the BDNF excitatory action on synaptic transmission". Trabalho apresentado em 4th Congress of the Federation of the European Pharmacological Societies (EPHAR), Porto, Portugal, 2004. Diógenes, MJ; Sebastião, AM; Ribeiro, JA. "Adenosine enhances the BDNF excitatory action on synaptic transmission at the rat hippocampus through cyclic AMP/PKA signaling system". Trabalho apresentado em 4th FENS Forum of Neuroscience, Lisboa, Portugal, 2004. Diógenes, MJ; Fernandes, CC; Sebastião, AM; Ribeiro, JA. "Cross-talk between adenosine receptors and brain-derived neurotrophic factor (BDNF) receptors". Trabalho apresentado em Purines, Carolina do Norte, Estados Unidos, 2004. Fernandes, CC; Diógenes, MJ; Sebastião, AM; Ribeiro, JA. "Presynaptic mechanisms facilitate axcitatory action of brain derived neurotrophic factor on hippocampal synaptic transmission". Trabalho apresentado em Purines, North Caroline, Estados Unidos, 2004. Diógenes, MJ; Sebastião, AM; Ribeiro, JA. "The role of adenosine in the excitatory action of Brain Derived Neurotrophic Factor on hippocampal synaptic transmission". Trabalho apresentado em IBRO, Praga, República Checa, 2003. Diógenes, MJ; Sebastião, AM; Ribeiro, JA. "Brain derived neurotrophic factor facilitation of synaptic transmission in rat hippocampus is dependent on A2A adenosine receptor activation". Trabalho apresentado em British Pharmacological Society, Brighton, Reino Unido*, 2003.
Resumo em conferência	Ribeiro-Rodrigues, Leonor; Fonseca-Gomes, J; Paulo, SL; Zavalko, S; Paiva VH; Sebastião, AM; Xapelli, S; Diógenes, MJ. "Cleavage of BDNF receptor in a model of epilepsy". Trabalho apresentado em SPF Meeting 2021 (Virtual meeting), 2021. Publicado Gomes, JI; Fonseca-Gomes, J; Vicente Miranda, H; Sebastião, AM; Diógenes, MJ; Vaz, SH. "Gliotransmission role upon amyloid-ß mediated excitotoxicity". Trabalho apresentado em XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia, Porto, 2019. Gomes, JI; Fonseca-Gomes, J; Vicente Miranda, H; Diógenes, MJ; Vaz, SH. "Role of astrocytic signaling upon synaptic plasticity on AD-like conditions". Trabalho apresentado em 14th Young European Scientist Meeting, Porto, 2019. Fonseca-Gomes, J; Vaz, SH; Rodrigues, TM; Belo, RF; Mäkinen, P; Takalo, M; Lesnikova, A; et al. "Development of a novel therapeutic strategy to prevent the loss of BDNF signalling in Alzheimer’s disease". Trabalho apresentado em 14th International Conference on Alzheimer’s & Parkinson’s diseases, Lisboa, 2019. Tanqueiro, SR; Mouro, FM; Sebastião, AM; Simões do Couto, F; Dawson, N; Diógenes, MJ. "Interplay between BDNF signalling and cognitive alterations in the subchronic phencyclidine model of schizophrenia". Trabalho apresentado em Meeting of NeurULisboa Doctoral Programme, Lisboa, 2019. Fonseca-Gomes, J; Vaz, SH; Rodrigues, TM; Jerónimo-Santos, A; Miranda-Lourenço, C; Tanqueiro, SR; Belo, RF; et al. "TrkB-ICD: what is its role in vivo and could the prevention of its formation be considered a therapeutic strategy for Alzheimer’s disease?". Trabalho apresentado em Meeting of NeurULisboa Doctoral Programme, Lisboa, 2019. Ferreira, CB; Coelho, JE; Temido-Ferreira, M; Miranda-Lourenço, C; Fonseca-Gomes, J; Belo, RF; Tanqueiro, SR; et al. "Unveiling the effect of SEPT5 on synaptic function". Trabalho apresentado em Meeting of NeurULisboa Doctoral Programme, Lisboa, 2019. Tanqueiro, SR; Mouro, FM; Sebastião, AM; Simões do Couto, F; Dawson, N; Diógenes, MJ. "Is there any relation between BDNF loss of function and cognitive deficits in phencyclidine-induced mouse model of schizophrenia". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, 2019. Miranda-Lourenco, C; Rosa, J; Palminha, C; Duarte, ST; Colino-Oliveira, M; Gomes, R; Rodrigues, TM; et al. "Adenosinergic system and BDNF signalling in a severe and a mild mouse model of Rett Syndrome". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, 2019. Fonseca-Gomes, J; Mouro, FM; Tanqueiro, SR; Miranda-Lourenco, C; Belo, RF; Ferreira, CB; Ribeiro, FF; et al. "TrkB-ICD fragment impact upon normal physiology". Trabalho apresentado em 5th Meeting of the Mind-Brain College of the University of Lisbon, Lisboa, 2019. Belo, RF; Fonseca-Gomes, J; Vicente Miranda, H; Outeiro, TF; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "The neuroprotective effect of Amidated-Kyotorphin on Alzheimer’s Disease". Trabalho apresentado em XIII CAML PhD Student’s Meeting, Lisboa, 2019. Fonseca-Gomes, J; Vaz, SH; Rodrigues, TM; Jerónimo-Santos, A; Belo, RF; Mäkinen, P; Takalo, M; et al. "Relevance of BDNF receptor cleavage on Alzheimer’s disease pathophysiology". Trabalho apresentado em XIII CAML PhD Student’s Meeting, Lisboa, 2019. Fonseca-Gomes, J; Rodrigues, TM; Vaz, SH; Ramalho, RM; Vicente Miranda, H; Rombo, DM; Belo, RF; et al. "Prevention of BDNF receptor cleavage as a therapeutic strategy for Alzheimer’s disease pathophysiology". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, 2019. Miranda-Lourenço, C; Palminha, C; Duarte, ST; Gaspar, C; Colino-Oliveira, M; Rosa, J; Gomes, Rui; et al. "Reestablishment of adenosine levels: a possible strategy for Rett Syndrome". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, 2019. Marcelino, H; Santos, CR; Nogueira, VS; Fonseca-Gomes, J; Tomás, J; Diógenes, MJ; Sebastião, AM; Cascalheira, JF. "The inhibitory effect of adenosine on human astrocyte proliferation is absent in glioblastoma cell lines". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019. Publicado • 10.3389/conf.fncel.2019.01.00004 Miranda-Lourenço, C; Duarte, ST; Palminha, C; Colino-Oliveira, M; Rosa, J; Gomes, R; Rodrigues, TM; et al. "Reestablishment of adenosine levels: a possible strategy for Rett Syndrome". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019. Publicado • 10.3389/conf.fncel.2019.01.00046 Mouro, FM; Fonseca-Gomes, J; Miranda-Lourenço, C; Sebastião, AM; Diógenes, MJ. "Molecular evaluation of the endocannabinoid system in RTT mice-model: implications for cannabinoid-based treatments". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019. Publicado • 10.3389/conf.fncel.2019.01.00003 Tanqueiro, SR; Mouro, FM; Sebastião, AM; Simões do Couto, F; Dawson, N; Diógenes, MJ. "Does BDNF loss of function in the prefrontal cortex underlie cognitive deficits in the subchronic phencyclidine model of schizophrenia?". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019. Publicado • 10.3389/conf.fncel.2019.01.00017 Paulo, SL; Miranda-Lourenço, C; Belo, RF; Rodrigues, RS; Tanqueiro, SR; Fonseca-Gomes, J; Sebastião, AM; Xapelli, S; Diógenes, MJ. "High caloric intake and aging: consequences for synaptic plasticity and rat behaviour performance". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), 2019. Publicado • 10.3389/conf.fncel.2019.01.00037 Paulo, SL; Miranda-Lourenço, C; Belo, RF; Rodrigues, RS; Tanqueiro, SR; Fonseca-Gomes, J; Sebastião, AM; Xapelli, S; Diógenes, MJ. "A high caloric diet induces memory impairment and disrupted synaptic plasticity in aged rats". Trabalho apresentado em ISN-ASN 2019 Meeting, Montreal, 2019. Publicado • 10.1111/jnc.14777 Paulo, SL; Miranda-Lourenço, C; Belo, RF; Rodrigues, RS; Tanqueiro, SR; Fonseca-Gomes, J; Sebastião, AM; Xapelli, S; Diógenes, MJ. "The only free cheese is in the rat trap: long-term consequences of a high-caloric diet upon memory and plasticity". Trabalho apresentado em 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2019. Paulo, SL; Miranda-Lourenço, C; Belo, RF; Rodrigues, RS; Tanqueiro, SR; Fonseca-Gomes, J; Sebastião, AM; Xapelli, S; Diógenes, MJ. "The only free cheese is in the rat trap: long-term consequences of a high-caloric diet upon memory and plasticity (poster presentation)". Trabalho apresentado em 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC), Lisboa, 2019. Submetido Fonseca-Gomes, J; Vaz, SH; Rodrigues, TM; Jerónimo-Santos, A; Belo, RF; Vicente Miranda, H; Outeiro, TF; et al. "Prevention of BDNF receptor cleavage as a novel therapeutic strategy for Alzheimer´s Disease". Trabalho apresentado em 3rd Annual Scientific Meeting of the SynaNet, Lisboa, 2018. Tanqueiro, SR; Almeida-Silva, G; Mouro, FM; Dawson, N; Sebastião, AM; Diógenes, MJ. "Dysfuntion of BDNF signalling in the prefrontal cortex as a potential key to understand cognitive alterations in the subchronic phencycline model of schizophrenia". Trabalho apresentado em 3rd Annual Scientific Meeting of the SynaNet, Lisboa, 2018. Fonseca-Gomes, J; Vaz, SH; Manso, N; Belo, RF; Tanqueiro, SR; Miranda-Lourenco, C; Enguita FJ; et al. "Novel therapeutic strategy and new biomarker for Alzheimer´s Disease based on Brain–derived neurotrophic factor receptor cleavage". Trabalho apresentado em 32ª Reunião do Grupo de Estudos de Envelhecimento e Demência (GEECD), Lisboa, 2018. Belo, RF; Fonseca-Gomes, J; Vicente Miranda, H; Outeiro, TF; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "The neuroprotective action of Amidated-kyotorphin on Alzheimer’s Disease". Trabalho apresentado em 32ª Reunião do Grupo de Estudos de Envelhecimento e Demência (GEECD), Lisboa, 2018. Paulo, SL; Miranda-Lourenço, C; Belo, RF; Rodrigues, RS; Tanqueiro, SR; Fonseca-Gomes, J; Gonçalves-Rosa, N; et al. "Impact of a high sugar diet during rat aging on synaptic plasticity, hippocampal neurogenesis and behaviour performance". Trabalho apresentado em 4th Students Meeting of the Mind-Brain College, Lisboa, 2018. Belo, RF; Fonseca-Gomes, J; Vicente Miranda, H; Outeiro, TF; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "A new insight about Amidated-Kyotorphin on Alzheimer's Disease therapy". Trabalho apresentado em 4th Students Meeting of the Mind-Brain College, Lisboa, 2018. Fonseca-Gomes, J; Jerónimo-Santos, A; Belo, RF; Vaz, SH; Rodrigues, TM; Marttinen, M; Mäkinen, P; et al. "Novel therapeutic strategy to prevent the loss of BDNF siganlling in Alzheimer’s disease". Trabalho apresentado em 4th Students Meeting of the Mind-Brain College, Lisboa, 2018. Paulo, SP; Rodrigues, RS; Ribeiro, FF; Fonseca-Gomes, J; Shvachiy, L; Coelho, JE; Diógenes, MJ; et al. "Intracerebroventricular injection of Aß1-42 peptide in adult hippocampal neurogenesis". Trabalho apresentado em XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2018. Belo, RF; Fonseca-Gomes, J; Vaz, SH; Perez-Peinado, C; Valle, J; Andreu, D; Sebastião, AM; et al. "Elucidating the effects of kyotorphin on the brain". Trabalho apresentado em XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2018. Fonseca-Gomes, J; Vaz, SH; Rodrigues, TM; Marttinen, M; Mäkinen, P; Takalo, M; Haapasalo, A; et al. "Detection of BDNF receptor cleavage in Alzheimer’s Disease human brain samples and search for novel therapeutic strategy". Trabalho apresentado em XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2018. Tanqueiro, SR; Ramalho, RM; Sebastião, AM; Diógenes, MJ. "NMDA receptors play a key role in Amyloid Beta-mediated BDNF loss of function". Trabalho apresentado em XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2018. Ferreira, CB; Kaisa, M; Paldanius, A; Mäkinen, P; Sebastião, AM; de Mendonça, A; Diogenes MJ. "Role of SEPT5 in the APP processing and Aß peptide production in SH-SY5Y-APP751 neuroblastoma cells". Trabalho apresentado em XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2018. Miranda-Lourenco, C; Palminha, C; Duarte, ST; Gaspar, C; Colino-Oliveira, M; Gomes, R; Ferreira, S.; et al. "Deregulation on adenosinergic system and on BDNF signaling in Rett syndrome". Trabalho apresentado em XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2018. Fonseca-Gomes, J; Jerónimo-Santos, A; Vaz, SH; Rodrigues, TM; Manso, N; Marttinen, M; Mäkinen, P; et al. "BDNF receptor cleavage in Alzheimer’s disease: detection in human brain samples and its prevention as a new therapeutic tool". Trabalho apresentado em III Meeting of NeurULisboa Doctoral Programme, Lisboa, 2018. Tanqueiro, SR; Almeida-Silva, G; Mouro, FM; Dawson, N; Sebastião, AM; Diógenes, MJ. "The interplay between loss of BDNF signaling and cognitive dysfunction in schizophrenia". Trabalho apresentado em III Meeting of NeurULisboa Doctoral Programme, Lisboa, 2018. Fonseca-Gomes, J; Marttinen, M; Mäkinen, P; Takalo, M; Haapasalo, A; Hiltunen, M; Sebastião, AM; Diógenes, MJ. "Assessment of TrkB-FL and TrkB-ICD receptor levels in Alzheimer’s Disease human samples". Trabalho apresentado em 2nd Annual Scientific Meeting of the Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet), 2018. Ferreira, CB; Kaisa, M; Paldanius, A; Mäkinen, P; Sebastião, AM; de Mendonça, A; Diógenes, MJ; Hiltunen, M. "SEPT5 as a potential player in the APP processing and Aß peptide production in SH-SY5Y-APP751 neuroblastoma cells". Trabalho apresentado em 2nd Annual Scientific Meeting of the Neurologic and Psychiatric Disorders: from synapses to networks (SynaNet), 2018. Miranda-Lourenço, C; Ferreira, S.; Sebastião, AM; Diógenes, MJ. "Alterations in BDNF signalling and adenosinergic system: from presymptomatic to symptomatic stage of Rett Syndrome". Trabalho apresentado em XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2017. Belo, RF; Neves, V; Castanho, M; Sebastião, AM; Diógenes, MJ. "Kyotorphin and amidated-kyotorphin effects on hippocampal synaptic transmission and on calpains and caspases activation". Trabalho apresentado em XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2017. Fonseca-Gomes, J; Jerónimo-Santos, A; Rodrigues, TM; Vaz, SH; Sebastião, AM; Diógenes, MJ. "Protection of BDNF receptor cleavage as a possible therapeutic strategy for Alzheimer’s Disease". Trabalho apresentado em Alzheimer’s Global Summit, Lisboa, 2017. Belo, RF; Perez-Peinado, C; Valle, J; Andreu, D; Sebastião, AM; Neves, V; Castanho, M; Diógenes, MJ. "Neuronal mechanisms behind Kyotorphin and Amidated-Kyotorphin effects". Trabalho apresentado em 3rd M2B PhD students meeting, Coimbra, 2017. Fonseca-Gomes, J; Sebastião, AM; Diógenes, MJ. "BDNF receptor cleavage: Relevance for Alzheimer’s Disease pathophysiology". Trabalho apresentado em Meeting of NeurULisboa Doctoral Programme, Lisboa, 2017. Tanqueiro, SR; Almeida-Silva, G; Mouro, FM; Dawson, N; Sebastião, AM; Diógenes, MJ. "Modulation of BDNF effects by adenosine: a good strategy in schizophrenia?". Trabalho apresentado em Meeting of NeurULisboa Doctoral Programme, Lisboa, 2017. Fonseca-Gomes, J; Jerónimo-Santos, A; Sebastião, AM; Diógenes, MJ. "TrkB-ICD: Characterization of this newly discovered TrkB receptor fragment formed by calpain cleavage". Trabalho apresentado em XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, Porto, 2016. Miranda-Lourenço, C; Palminha, C; Duarte, ST; Gaspar, C; Colino-Oliveira, M; Gomes, R; Ferreira, S.; et al. "Adenosinergic system: a new central player in Rett Syndrome". Trabalho apresentado em XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, Porto, 2016. Tanqueiro, SR; Ramalho, RM; Sebastião, AM; Diógenes, MJ. "Extrasynaptic NMDA receptors inhibition prevents the loss of BDNF functions in the context of Alzheimer’s Disease". Trabalho apresentado em XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia, Porto, 2016. Fonseca-Gomes, J; Sebastião, AM; Diógenes, MJ. "BDNF receptor cleavage: relevance for Alzheimer's Disease pathophysiology". Trabalho apresentado em X IMM/CAML PhD Meeting, Lisboa, 2016. Belo, RF; Sebastião, AM; Neves, V; Diógenes, MJ. "Kyotorphin as new pharmacological therapeutic strategy for Alzheimer’s Disease". Trabalho apresentado em X IMM/CAML PhD Meeting, Lisboa, 2016. Miranda-Lourenço, C; Diógenes, MJ. "Regulation of adenosinergic system as a new therapeutic strategy in Rett Syndrome". Trabalho apresentado em X IMM/CAML PhD Meeting, Lisboa, 2016. Duarte, ST; Palminha, C; Sebastião, AM; Diógenes, MJ. "P197 – 3009: Adenosine Receptors as new therapeutic targets in Rett Syndrome". Trabalho apresentado em 11th EPNS Congress, 2015. Publicado • 10.1016/S1090-3798(15)30510-9 Abrantes, HD; Avelar, P; Diógenes, MJ; Sebastião, AM; Vaz, SH. "mGluR5-mediated calcium signalling in rat cortical primary astrocytes is modulated by adenosine A1 and A2A receptors". Trabalho apresentado em 12th European Meeting on Glial Cell Function in Health and Disease, 2015. Jerónimo-Santos, A; Vaz, SH; Parreira, S; Lérias, SR; Caetano, AP; Buée-Scherrer, V; Castrén, E; et al. "Dysregulation of TrkB receptors and BDNF function by amyloid-ß peptide is mediated by calpain". Trabalho apresentado em XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2014. Rodrigues, TM; Sebastião, AM; Diógenes, MJ. "BDNF mediated attenuation of hippocampal long-term depression is dependent on adenosine A2A receptors activation". Trabalho apresentado em XLIV Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2014. Almeida, J; Vargas, M; Diógenes, MJ; Pais, TF; Sebastião, AM. "Effect of microglial expression of Sirt2 in LTP". Trabalho apresentado em 17º Workshop Educação pela Ciência GAPIC, Lisboa, 2014. Rodrigues, TM; Sebastião, AM; Diógenes, MJ. "Adenosine A2A Receptors (A2ARs): novel upstream regulators of Brain-Derived Neurotrophic Factor (BDNF)-mediated attenuation of hippocampal Long-Term Depression (LTD)". Trabalho apresentado em 4th AIMS Meeting, Lisboa, 2013. Jerónimo-Santos, A; Vaz, SH; Parreira, S; Lérias, SR; Caetano, AP; Buée-Scherrer, V; Castrén, E; et al. "Amyloid-ß peptide dysregulates TrkB receptors and BDNF function by a calpain-dependent mechanism". Trabalho apresentado em XIII Meeting of the Portuguese Society for Neuroscience, Luso, 2013. Lérias, SR; Parreira, S; Vaz, SH; Diógenes, MJ; Sebastião, AM. "Effect of the amyloid- ß peptide in GABA release from hippocampal synaptosomes: modulation by BDNF". Trabalho apresentado em XLII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2012. Jerónimo-Santos, A; Batalha, VL; Muller, C; Hockemeyer, J; Sebastião, AM; Lopes, LV; Diógenes, MJ. "Chronic blockade of adenosine A2A receptors prevents BDNF effect on hippocampal LTP". Trabalho apresentado em XLII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2012. Pinho, JS; Duque do Vale, R; Batalha, VL; Costenla, AR; Valadas, J; Pereira, A; Sebastião, AM; et al. "Compensatory long-term potentiation in aged rats". Trabalho apresentado em XLII Reunião Anual da Sociedade Portuguesa de Farmacologia, Lisboa, 2012. Rodrigues, TM; Sebastião, AM; Diógenes, MJ. "Adenosine A2A Receptors: novel upstream regulators of Brain-Derived Neurotrophic Factor mediated attenuation of hippocampal Long-Term Depression". Trabalho apresentado em 3rd AIMS Meeting, Lisboa, 2012. Rodrigues, TM; Sebastião, AM; Diógenes, MJ. "Modulation of Long-Term Depression (LTD) by Brain-Derived Neurotrophic Factor (BDNF) and its interplay with Adenosine A2A Receptors". Trabalho apresentado em Fundação Amadeu Dias/Universidade de Lisboa Projects Presentation Forum, Lisboa, 2012. Brites, D; Silva SL; Oliveira, A; Vaz AR; Diógenes, MJ; van Rooijen N; Sebastião, AM; et al. "Microglial faces featuring a potential pathological neural/glial behavior highly common in neonatal life". Trabalho apresentado em 10th European meeting on Glial Cells in Health and Disease, 2011. Publicado • 10.1002/glia.21210 Duque do Vale, R; Pinho, J; Lopes, LV; Ribeiro, JA; Sebastião, AM; de Mendonça, A; Diógenes, MJ. "Blockade of NMDA receptors by memantine decreases the augmented LTP in old rats hippocampus to physiologic values". Trabalho apresentado em Berlin Brain Days, Berlim, 2011. Costenla, AR; Diógenes, MJ; Agostinho, PM; de Mendonça, A; Cunha, RA. "Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon hippocampus aging". Trabalho apresentado em European Winter Conference on Brain Research, Alpes, 2011. Calçada, D; Ribeiro, JA; Sebastião, AM; Diógenes, MJ. "The role of lithium on apoptotic cell death induced by amyloid-ß peptide". Trabalho apresentado em XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2011. Pinho, JS; Batalha, VL; Dias, RB; Constela, AR; Sebastião, AM; Lopes, LV; de Mendonça, A; Diógenes, MJ. "Effect of memantine upon ageing: impact on hippocampal dependent memory". Trabalho apresentado em XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2011. Diógenes, MJ; Costenla, AR; Lopes, LV; Jerónimo-Santos, A; Sousa, VC; Fontinha, BM; Ribeiro, JA; Sebastião, AM. "Enhancement of LTP in aged rats is dependent on endogenous BDNF". Trabalho apresentado em XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2011. Duque do Vale, R; Lopes, LV; Ribeiro, JA; Sebastião, AM; de Mendonça, A; Diógenes, MJ. "Detailing the age-related effects of memantine on long-term potentiation". Trabalho apresentado em XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2011. Rombo, DM; Dias, RB; Maiolino, F; Guerreiro, P; Vicente Miranda, H; Sebastião, AM; Diógenes, MJ; Lopes, LV; Outeiro, TF. "Changes in NMDA and AMPA receptor-mediated glutamatergirc transmission by alpha-synuclein". Trabalho apresentado em XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2011. Valadas, JS; Batalha, VL; Diógenes, MJ; Sebastião, AM; Lopes, LV. "Protective interaction between adenosine A2A receptors and corticotrophin-releasing factor (CRF) in rat cortical neurons". Trabalho apresentado em XLI Reunião Anual da Sociedade Portuguesa de Farmacologia, Coimbra, 2011. Guerreiro, C; Ferreira, C; Vaz, SH; Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "Modulation of BDNF effect on glutamate release in Synaptosomes by amyloid-ß peptide". Trabalho apresentado em 6th Young European Scientist Meeting, Porto, 2011. Parreira, S; Lérias, SR; Vaz, SH; Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "Effect of the amyloid-ß peptide in GABA release from hippocampal or synaptosomes: modulation by BDNF". Trabalho apresentado em 6th Young European Scientist Meeting, Porto, 2011. Branco, JM; Campos, CF; Corte-Real, A; Neves, JB; Rodrigues, FB; Sousa, David; Teixeira, Soraia; et al. "Mechanisms of patent ductus arteriosus after gestational exposure to indomethacin". Trabalho apresentado em European journal of medical research, 2010. Duque do Vale, R; Lopes, LV; Ribeiro, JA; Sebastião, AM; de Mendonça, A; Diógenes, MJ. "Efeito da memantina na Potenciação de Longa Duração do hipocampo, durante o envelhecimento". Trabalho apresentado em Encontro Nacional de Jovens Estudantes de Medicina – ENJOY Med’10, Lisboa, 2010. Jerónimo-Santos, A; Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "Amyloid-beta induces changes in TrkB receptors densities in rat neuronal cultures: Influence on apoptosis". Trabalho apresentado em XL Reunião Anual da Sociedade Portuguesa de Farmacologia, Porto, 2009. Diógenes, MJ. "Enhanced impact of adenosine A2A receptor blockade on the control of long term potentiation in the hippocampus of aged rats". Trabalho apresentado em Purines, 2008. Publicado • 10.1007/s11302-008-9116-0 Sebastião, AM; Diógenes, MJ; Pousinha, PI; Fernandes, CC; Pinto-Duarte, A; Gomes, CA; Vaz, SH; Ribeiro, JA. "Adenosine regulation of neurotrophin synaptic actions". Trabalho apresentado em Purines, 2006. Publicado • 10.1007/s11302-006-9006-2 Diógenes, MJ; Ribeiro, JA; Sebastião, AM. "Endogenous A(2A) receptor activation triggers the BDNF excitatory actions on synaptic transmission". 2004. Diógenes, MJ; Sebastião, AM; Ribeiro, JA. "Brain derived neurotrophic factor facilitation of synaptic transmission in rat hippocampus is dependent on A2A adenosine receptor activation". Trabalho apresentado em British Pharmacological Society Meeting*, 2003. Rodrigues, CMP; Solá, S; Silva, R.; Diógenes, MJ; Brites, D. "Apoptosis induced by deoxycholic acid, unconjugated bilirubin and amyloid beta-peptide reflects mitochondrial perturbation which may be inhibited by ursodeoxycholic acid". 2000. Rodrigues, CMP; Solá, S; Silva, R.; Diógenes, MJ; Brites, D. "Implication of mitochondria in apoptosis by the action of bilirubin and glycoquenodeoxycholate". 2000.
Tese / Dissertação	Diógenes, Maria José de Oliveira, 1977-. "Crosstalk between adenosine A2A receptors and the Trk receptores for brain-derived neurotrophic factor (BDNF) at the rat hippocampus". Doutoramento, Universidade de Lisboa Faculdade de Medicina, 2008. http://sibul.reitoria.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000552776.

Propriedade Intelectual

Patente

Maria José de Oliveira Diógenes Nogueira [PT]; João Filipe Fonseca Gomes [PT]; André Jerónimo Santos [PT]; Ana Maria de. 2022. "Therapeutic agents, pharmaceutical composition, and associated biomarkers based on TRK-B".
Diógenes, MJ; Fonseca-Gomes, J; Sebastião, AM; Duarte, C; Jerónimo-Santos, A. 2020. "Therapeutic Agents, Pharmaceutical Compositions, and Associated Biomarkers Application". Portugal.
Pendente

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2020/12/02	Development of a novel therapeutic strategy to prevent the loss of BDNF signalling in Alzheimer’s disease	1st International CAPES Print Symposium in Neurosciences Universidade Federal do Ceará (Virtual)
2020/11/18	Adenosinergic system impairment as a new therapeutic avenue to rescue BDNF signalling in Rett Syndrome (Presented by: Miranda-Lourenço, C)	Neurology Congress 2020 Sociedade Portuguesa de Neurologia
2020/10/18	Rett Syndrome, Health and Society	Research into Rett's Syndrome Associação de Pais e Amigos RETT (ANPAR) (Virtual)
2020/04/27	Can I be a scientist in Portugal?	Escola Secundária do Bocage (Virtual)
2019/11/25	The impact of BDNF receptor cleavage in Alzheimer's disease-associated Neuroinflammation (Presented by: Ferreira-Manso, M)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2019/11/11	Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome/exosome signalling in Alzheimer¿s Disease (Presented by: Costa-Coelho, T)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2019/10/14	Characterization of BDNF signalling in the prefrontal cortex in the neonatal phencyclidine mouse model of schizophrenia (Presented by: Freitas, CF)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2019/10/14	Searching for a new biomarker for Alzheimer's Disease based on BDNF receptor cleavage (Presented by: Borlido, C)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2019/09/30	PhD project: Interaction between BDNF/TrkB signaling and neurogenesis in epilepsy (Presented by: Ribeiro-Rodrigues, L)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2019/04/29	Playing with adenosine on rett syndrome mouse model (Presented by: Miranda-Lourenço, C)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2019/03/19	Interplay between BDNF signaling and cognitive alterations in the subchronic phencyclidine mouse model of schizophrenia (Presented by: Tanqueiro, SR)	iMM Pizza Seminar Instituto de Medicina Molecular (Lisboa, Portugal)
2018/07/03	Opening Conference “Functional Brain”	II Special Education Meeting of Escola Secundária do Pinhal Novo Escola Secundária do Pinhal Novo (Setúbal, Portugal)
2018/02/22	NMDA receptors play a key role in Amyloid Beta-mediated BDNF loss of function (Presented by: Tanqueiro, SR)	Aging and Dementia Study Group Instituto de Medicina Molecular (Lisboa, Portugal)
2017/12/11	Characterization of the adenosinergic system and the BDNF-mediated signalling in heterozygous females of the Rett mouse model (Presented by: Rosa, J)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2017/03/06	Rare Diseases and Orphan Drugs: Challenges and Opportunities	Conference of "redeSAÚDE" Universidade de Lisboa Faculdade de Medicina (Lisboa, Portugal)
2017/01/09	Research into Rett's Syndrome at the University of Lisbon	Conferences circle '17 - RedeSaúde "Precision Medicine" Universidade de Lisboa Faculdade de Medicina
2016/07/06	Age-related alterations of fine control of neuronal communication	Summer School 'Ageing Brain' 2016 European Institute of Innovation and Technology (EIT) Health (Groningen , Países Baixos)
2016	From the characterization of adenosinergic system to a future therapeutic strategy for Rett Syndrome (Presented by: Miranda-Lourenço, C)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2015/11/13	Lecture “Rett's Syndrome”	I Rett Syndrome Seminar in Portugal Associação Nacional de Pais e Amigos Rett (ANPAR) (Amora, Portugal)
2015	Study the function of the newly discovered TrkB receptor fragment (TrkB-ICD) formed by calpain cleavage (Presented by: Fonseca-Gomes, J)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2015	Deciphering the mechanisms underlying the loss of BDNF neuroprotection in an Alzheimer¿s disease model (Presented by: Tanqueiro, SR)	Neurosciences Seminar Universidade de Lisboa, Faculdade de Medicina, Instituto de Farmacologia e Neurociências (Lisboa, Portugal)
2012/03	Long-term potentiation and aging	3º AIMS meeting Universidade de Lisboa, Faculdade de Medicina (Lisboa, Portugal)
2011/06/03	Chronic administration of memantine in aged rats: impact on hippocampal dependent memory (Presented by: Pinho, JS)	25th Meeting of the Study Group on Brain Aging and Dementia Hotel dos Templários (Tomar, Portugal)
2003/06/12	Adenosine triggers an excitatory action of Brain-derived neurotrophic factor on hippocampal synaptic transmission	8th Meeting of the Portuguese Society of Neurosciences Grande Hotel da Curia (Anadia, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2019 - Atual	PhD thesis: Interaction between BDNF/TrkB signaling and neurogenesis in epilepsy Orientador de Leonor Pedro Oliveira Ribeiro Rodrigues	Neuroscience (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - Atual	PhD Thesis: Anti-TNF pharmacokinetics: In vitro model Coorientador de Cátia Rocha	Environmental Health (Doutoramento) Universidade de Lisboa Instituto de Saúde Ambiental, Portugal
2017 - Atual	PhD thesis: The role of septins on synaptic function and on amyloid precursor protein processing Orientador de Catarina Beatriz da Silva Ferreira	Neuroscience (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - Atual	Kyotorphin as new pharmacological therapeutic strategy for Alzheimer’s Disease Orientador de Rita Alexandra Figueira Belo	PhD Medical Biochemistry and Biophysics (M2B) (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2022	PhD thesis: Regulation of adenosine levels as a new therapeutic strategy for Rett Syndrome Orientador de Catarina Miranda Lourenço	Neuroscience (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2021/06/13	Master thesis: Unveiling paracrine dissemination and toxicity of neuronal TrkB-ICD via secretome/exosome signaling in Alzheimer¿s Disease Orientador de Tiago Rodrigo da Costa Coelho	Biochemistry for Health (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - 2021	Master Thesis: Search for novel compounds to prevent TrkB-FL cleavage Orientador	Neuroscience (Mestrado)
2020 - 2021	Master Thesis: Epigenetic changes in a mouse model of Rett Syndrome: optimizing a technique to evaluate DNA methylation Orientador	Master (Mestrado)
2020 - 2021	Master Thesis: Efeito da administração de memantina ao longo do envelhecimento nos níveis dos recetores de BDNF Orientador
2019 - 2021	Master thesis: Characterization of BDNF signalling in the prefrontal cortex in the neonatal phencyclidine mouse model of schizophrenia Orientador de Céline Felicidade Freitas	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2021	PhD Thesis: Modulation of BDNF effects by adenosine: a new strategy for schizophrenia treatment? Orientador de Sara Luísa Ramalho Tanqueiro	Neuroscience (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2019 - 2020	Master thesis: Searching for a new biomarker for Alzheimer¿s Disease based on BDNF receptor cleavage Orientador de Carolina de Almeida Borlido	Biochemistry (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2018 - 2020	Master thesis: Role of SNARE-dependent gliotransmitters release by astrocytes upon Aß-mediated excitotoxicity Coorientador de Joana Isabel Ferreira da Graça Gomes	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2020	Adenosine levels reestablishment: new approach for the treatment of rett syndrome Orientador	Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2020	PhD thesis: BDNF receptor cleavage: relevance for Alzheimer¿s Disease pathophysiology Orientador de João Filipe Fonseca Gomes	Neuroscience (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2019	Master thesis: On the role of stress granules in autophagy Coorientador de Rebekah Cavaco Koppenol	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2018 - 2019	Molecular characterization of the endocannabinoid system in a mouse model of Rett Syndrome: implications for possible cannabinoid-based therapies Orientador de Luís Carlos Oliveira	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2019	Master thesis: Adenosinergic system and BDNF mediated-signalling in heterozygous females of a Rett syndrome mouse model Orientador de Jéssica Lúcia Albuquerque Rosa	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2018	Impact of selective inhibition of calpain-mediated TrkB-FL cleavage on synaptic plasticity Orientador de Nuno Manso	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2018	Adenosinergic signaling as a new pharmacological target for schizophrenia treatment? Orientador de Gustavo Filipe Almeida Silva	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2017 - 2018	Intracellular fragment of the BDNF receptor (TrkB-ICD): Impact on Gene Expression Orientador de Maria Marques Roque	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2017	Structural and functional consequences of social isolation in adolescence Coorientador de Ann Van der Jeugd
2014 - 2017	Deciphering the mechanisms underlying the loss of BDNF neuroprotection in Alzheimer’s disease Orientador de Rita Ramalho
2015 - 2016	Master thesis: The role of Brain Derived Neurotrophic factor (BDNF) on epilepsy Orientador de Diogo Filipe Andrade Guimarães	Medicine (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2016	Master thesis: The role of chocolate and theobromine in the prevention of Alzheimer¿s disease Coorientador de Afonso Maria da Silva Moreira	Medicine (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2016	Master thesis: Social memory in zebrafish: behavioral assessment and the role of Brain-Derived Neurotrophic Factor (BDNF) Coorientador	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2016	Master thesis: Deciphering the mechanisms underlying the loss of BDNF neuroprotection in an Alzheimer´s Disease Model Orientador de Sara Luísa Ramalho Tanqueiro	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2016	Study the fuction of the newly discovered TrkB receptor fragment (TrkB-ICD) formed by calpain cleavage Orientador de João Filipe Fonseca Gomes	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015	Master thesis: Influence of Brain-derived neurotrophic factor on the effect of amyloid-beta peptide upon calcium signalling in rat cortical astrocytes Orientador de Pedro Dinis Avelar Agostinho	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015	Master Thesis: Effect of microglial expression of SIRT 2 in Long-Term Potentiation Orientador de Joana Rita Alves Sá de Almeida	Medicine (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015	Master thesis: Characterization of adenosinergic system in Rett syndrome Orientador de Catarina Miranda Lourenço	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015	Hebbian Plasticity-driven changes on synaptic transmission Orientador de Tiago Rodrigues	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015	Role of microglial Sirt2 in synaptic plasticity in situations of inflammation Orientador de Joana Sá de Almeida	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2015	Role of microglial Sirt2 in synaptic plasticity in situations of inflammation Orientador de Mariana Vargas	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2014	Characterization of adenosine receptors in a Rett Syndrome Model Orientador de Cátia Alexandra Pêgas Palminha	Human Biology and Environment (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2014	Effect of microglial expression of Sirt2 in LTP Orientador de Joana Sá de Almeida	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2014	Effect of microglial expression of Sirt2 in LTP Orientador de Mariana Vargas	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2011 - 2014	Master thesis: Amyloid-ß peptide impairs BDNF effects upon GABA release from rat synaptosomes in a calpain dependent way Orientador de Sofia Ramos Rapaz Lérias	Medicine (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2011 - 2014	Master thesis: Modulation of GABA and glutamate release by brain-derived neurotrophic factor: role of adenosine A2A receptors Orientador de Sara Luísa dos Santos Bragança Parreira	Medicine (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2010 - 2014	PhD Thesis: Brain-derived neurotrophic factor and adenosine signalling on amyloid-ß peptide induced toxicity: impact on hippocampal function Orientador de André Jerónimo Santos	Programa Doutoral do Centro Académico Médico de Lisboa (CAML) (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - 2013	Master thesis: Effect of BDNF on synaptic and extrasynaptic NMDA currents Orientador de João Miguel Guerreiro Covita	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - 2013	Unraveling the effect of different Abeta species upon hippocampal synaptic plasticity and the neuroprotective role of BDNF Orientador de António Caetano	Medicine (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - 2013	Adenosine A2A Receptors and Zinc: New Avenues for the Treatment of Rett Syndrome Orientador de Tiago Rodrigues	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - 2013	Role of adenosine A2A receptors in the ß-amyloid peptide effect on BDNF signaling Orientador de Diogo Guimarães	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2011 - 2012	Modulation of Long-Term Depression (LTD) by Brain-Derived Neurotrophic Factor and its interplay with adenosine receptors Orientador de Tiago Rodrigues	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2011 - 2012	Effect of brain-derived neurotrophic factor on the release of gamma-amino butyric acid in rat hippocampus nerve endings incubated with ß-amyloid peptide Orientador de Sofia Rapaz Lérias	Medicine (Iniciação científica) Universidade de Lisboa Faculdade de Medicina, Portugal
2010 - 2012	Master thesis: Detailing the age-related effects of memantine on long-term potentiation Orientador de Rúben Duque do Vale	Medicine (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2010 - 2011	Master thesis: Effect of memantine in aging: the impact of hippocampal dependent memory Orientador de Júlia Sabrina Pinho	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - 2010	Master thesis: The role of lithium on apoptotic cell death induced by amyloid-ß peptide Orientador de Daniela Calçada	Neuroscience (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2009	Master thesis: Role of adenosine A2A receptors upon the neuroprotection effect of BDNF against neuronal death Orientador de André Jerónimo Santos	Biochemistry (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2020 - 2020	7th Edition Beyond MEd (2020 - 2020) Encontro (Coorganizador)	Faculdade de Medicina, Universidade de Lisboa, Portugal
2019/01 - 2019/06/01	VI Meeting of the Portuguese Society of Neurosciences (2019/05/30 - 2019/06/01) Encontro (Membro da Comissão Organizadora)	Instituto de Medicina Molecular, Portugal Universidade de Lisboa Faculdade de Medicina, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Sociedade Portuguesa de Neurociências, S.P.N., Portugal
2018/09 - 2019/04/30	Candidate's Day 2019 (Dia do Candidato 2019) (2019/04/30) Outro (Presidente da Comissão Organizadora)	Universidade de Lisboa Faculdade de Medicina, Portugal
2018/10 - 2018/10	6th Edition Beyond MEd (2019/10/23 - 2019/10/23) Congresso (Membro da Comissão Organizadora)	Universidade de Lisboa Faculdade de Medicina, Portugal
2018/01 - 2018/02/07	XLVIII Annual Meeting of the Portuguese Society of Pharmacology (2018/02/05 - 2018/02/07) Encontro (Presidente da Comissão Organizadora)	Universidade de Lisboa Faculdade de Medicina, Portugal Sociedade Portuguesa de Farmacologia, Portugal
2017/01 - 2017/03/02	International brain awareness week (2017/03/02 - 2017/03/02) Outro (Membro da Comissão Organizadora)	Instituto de Medicina Molecular, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2018/11/28 - 2018/11/28	Speaker at the round table "The impact of the SANTA CASA Neuroscience Awards and the need to boost Philanthropy in Science", moderated by journalist Pedro Carvalhas. Table composition: Manuel Heitor, Catarina Resende Oliveira, Maria José Diógenes and Carlos Fiolhais. Mesa-redonda	SANTA CASA Neuroscience Awards Santa Casa da Misericórdia de Lisboa, Portugal
2018/10/24 - 2018/10/24	The "Beyond MEd" congress is a privileged moment for teachers, researchers, clinicians and students (from FMUL and nationally) to debate the reality of Teaching at FMUL and in the other medical schools in Portugal, seeking to bring to the discussion new possibilities for growth and innovation in Medical Education. Congresso	5th Edition Beyond MEd Universidade de Lisboa Faculdade de Medicina, Portugal
2018/10/19 - 2018/10/19	Training event for teachers organized by the Department of Medical Education (DEM) of FMUL Outro	How to develop communication skills Universidade de Lisboa Faculdade de Medicina, Portugal
2018/09/28 - 2018/09/28	Training event for teachers organized by the Department of Medical Education (DEM) of FMUL Outro	How to set goals. Importance of Outcome based education Universidade de Lisboa Faculdade de Medicina, Portugal
2017/02/22 - 2017/02/22	Workshop designed specifically to help ULisboa teachers and researchers in the creation of online tests, using the Moodle platform Oficina (workshop)	Creating tests on the Moodle platform Universidade de Lisboa e-Learning Lab, Portugal
2017/01/27 - 2017/01/27	Workshop to explore the various Google tools associated with @ campus.ul.pt accounts, focusing in particular on Drive. Oficina (workshop)	Google Tools - accounts @ campus.ul.pt Universidade de Lisboa e-Learning Lab, Portugal
2016/11/29 - 2016/11/29	Speaker at the Round Table "Alzheimer's Disease" for the elderly Mesa-redonda	2nd students Meeting of Mind-Brain College of the University of Lisbon Colégio Mente-Cérebro da Universidade de Lisboa, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2020	The role of purinergic receptors in hippocampal mossy fiber sprouting during epileptogenesis Arguente principal	Xinli Xu (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2018	The role of signaling lipids in the nervous systemphysiology and pathology: mechanistic insights of the phospholipase D pathway inneurodegenerative diseases Arguente principal	Ana Francisca Rodrigues Vaz Bravo (Doutoramento) Universidade do Minho, Portugal
2018	Interaction between adenosine A2A receptors and cannabinoid CB1 receptors at the hippocampus : consequences for memory and plasticity Vogal	Francisco Melo Albuquerque Saraiva Mouro (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2017	Neurobiology of the circadian clock: metabolism control & implications for Alzheimer´s disease Arguente principal	António Manuel Carvalho da Silva (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017	Neuroexcitability control by adenosine and BDNF at the adult hippocampus Vogal	Mariana Colino de Oliveira (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2016	Autophagy in the hypothalamus: role of neuropeptide Y and impact on Synaptic Plasticity Arguente principal	Mariana Botelho da Rocha (Doutoramento) Universidade de Coimbra Faculdade de Farmácia, Portugal
2016	Characterization of the levels and G-protein coupling of adenosine A2A receptors in hippocampus and striatum of transgenic rats overexpressing A2A receptors in the brain Arguente principal	Marta Leal Bento (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2015	Primary progressive aphasia: neuropsychological analysis and evolution Vogal	Carolina Pires Maruta (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2014	Regulation of hnRNP A2/B1 and hnRNP K by synaptic activity and BDNF in the hippocampaus Arguente principal	Graciano da Silva Leal (Doutoramento) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2014	Role of S100B on central nervous system demyelination and remyelination Arguente principal	Vera Alexandra Padrela Martins Afonso (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014	Towards na adenosine wave detection for neuroscience applications- Na aptamer based approach Arguente principal	Marta Luísa Rodrigues Ornelas (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014	Using TUDCA to treat Alzheimer´s disease after pathology onset in APP/PS1 mice Arguente principal	Pedro Elói Antunes Dionísio (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014	BDNF impairs recovery of synaptic transmission after hypoxia even with blockage of adenosine A2A receptors Arguente principal	Afonso Nobre Pinto Cardoso (Mestrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2013	Risk management in hospital waste: a case study on the island of Pico Arguente principal	Joana Margarida Ribeiro Paulo (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013	Microglia demonstrate age-dependent performance and interaction wit beta-amyloid peptide Arguente principal	Gonçalo Manuel da Costa Lidónio (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2012	Setting GABA levels: GABA transporters modulation by adenosine receptors Vogal	Ana Sofia Cristóvão Ferreira (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2012	Modulation of NMDA receptors activity through adenosine A2A receptors in the hippocampus Arguente principal	Francisco Melo Albuquerque Saraiva Mouro (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2011	Dynamics and function of nicotinic acetylcholine receptors in the nervous system Vogal	Catarina da Cunha Fernandes (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2010	Molecular Interactions between neurotrophins and adenosine receptors at neuronal plasma membranes Vogal	Natalia Assaife Lopes (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2009	Presynaptic mechanisms in the hypoxia-induced suppression of synaptic transmission in the rat hippocampus Vogal	Joana Fernandes Esteves Soares Coelho (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2009	Study of the Neuroprotective Role of Insulin to Cellular Aggressions: Amyloid, Oxidative and Membrane Arguente principal	Ana Margarida Santos do Nascimento (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2021/02 - 2021/02	Meeting of the Portuguese Society of Pharmacology 2021	Lisboa, Portugal (Virtual meeting)
2020/03/26 - 2020/03/29	11th Aims Meeting	Lisboa, Portugal
2020/02/05 - 2020/02/07	Meeting of the Portuguese Society of Pharmacology 2020	Coimbra, Portugal
2020 - 2020	7th Beyond MEd	Lisboa, Portugal
2019/10/23 - 2019/10/23	6th Beyond MEd	Lisboa, Portugal
2019/10/11 - 2019/10/12	33rd Meeting of the Aging and Dementia Study Group (Grupo de Estudos de Envelhecimento e Demência-GEECD)	Coimbra, Portugal
2019/03/15 - 2019/03/17	10th Aims Meeting	Lisboa, Portugal
2019/02/06 - 2019/02/08	XLIX Annual Meeting of the Portuguese Pharmacology Society	Porto, Portugal
2018/10/24 - 2018/10/24	5th Beyond MEd	Lisboa, Portugal
2018/10/12 - 2018/10/13	32nd Meeting of the Aging and Dementia Study Group (Grupo de Estudos de Envelhecimento e Demência-GEECD)	Lisboa, Portugal
2018/03/16 - 2018/03/18	9th Aims Meeting	Lisboa, Portugal
2018/02/06 - 2018/02/06	XLVIII Annual Meeting of the Portuguese Pharmacology Society	Lisboa, Portugal
2017/11/15 - 2017/11/15	Small Working Group: Research in Medicine: why should you accept the challenge	Universidade de Lisboa Faculdade de Medicina
2017/10/19 - 2017/10/19	3rd Students Meeting of the Mind-Brain College of the University of Lisbon	Lisboa, Portugal
2017/02/02 - 2017/02/04	XLVII Annual Meeting of the Portuguese Pharmacology Society	Coimbra, Portugal
2016/02/04 - 2016/02/06	XLVI Annual Meeting of the Portuguese Pharmacology Society	Porto, Portugal
2015/02/04 - 2015/02/06	XLV Annual Meeting of the Portuguese Pharmacology Society	Lisboa, Portugal
2014/02/05 - 2014/02/07	XLIV Annual Meeting of the Portuguese Pharmacology Society	Coimbra, Portugal
2013/02/06 - 2013/02/08	XLIII Annual Meeting of the Portuguese Pharmacology Society	Porto, Portugal
2012/02/01 - 2012/02/03	XLII Annual Meeting of the Portuguese Pharmacology Society	Lisboa, Portugal
2011/02/02 - 2011/02/04	XLI Annual Meeting of the Portuguese Pharmacology Society	Coimbra, Portugal
2009/02/02 - 2009/02/04	XL Annual Meeting of the Portuguese Pharmacology Society	Porto, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2009 - Atual	Frontiers in Neuroscience (1662-453X)	Frontiers Media SA
2009 - Atual	Aging Cell (1474-9728)	Wiley (Blackwell Publishing)
2009 - Atual	Current Alzheimer Research (1567-2050)	Bentham Science
2009 - Atual	BMC Neuroscience (1471-2202)	Springer (Biomed Central Ltd.)
2009 - Atual	European Journal of Neuroscience (1460-9568)	Wiley (Blackwell Publishing)
2009 - Atual	Journal of Neurochemistry (1471-4159)	Wiley (Blackwell Publishing)
2009 - Atual	Neurochemical Research (1573-6903)	Springer-Verlag
2009 - Atual	Neuroscience Letters (0304-3940)	Elsevier
2009 - Atual	Neural Regeneration Research (1673-5374)	Medknow Publications
2009 - Atual	PLoS ONE (1932-6203)	Public Library of Science
2009 - Atual	Progress in Neuro-Psychopharmacology and Biological Psychiatry (0278-5846)	Elsevier
2009 - Atual	Frontiers in Molecular Neuroscience (1662-5099)	Frontiers Media SA
2009 - Atual	Acta Neuropathologica (1432-0533)	Springer-Verlag

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização
2016 - 2020	Participation in the doctoral thesis committee of Pedro Elói Antunes Dionísio Avaliador	Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2018	Evaluator of GAPIC projects under the 22nd "Education for Science" Program Avaliador	Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2018	Participation in the doctoral thesis committee of Mariana Temido Mendes Ferreira Avaliador	Universidade de Lisboa Faculdade de Medicina, Portugal
2011 - 2017	Participation in the doctoral thesis committee of Ana Filipa Ferreira da Cunha Ribeiro Avaliador	Universidade de Lisboa Faculdade de Medicina, Portugal
2012 - 2016	Participation in the doctoral thesis committee of Tomás Ribeiro Da Silva Lopes Da Fonseca Avaliador	Universidade de Lisboa Faculdade de Medicina, Portugal

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2018 - Atual	Neuroscience Fundamentals: Calcium Imaging Techniques and Electrophysiology	Medicine (Mestrado integrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - Atual	Module II-III: Organic and Functional Systems	Medicine (Mestrado integrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - Atual	Common Core III: Neuroscience	Medicine (Mestrado integrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - Atual	Neuroscience Seminars	Medicine (Mestrado integrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - Atual	"Neurotrophic Factors" and "Neuronal Regeneration and Degeneration"	Neuroscience (Mestrado integrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - Atual	Lab rotations	Neuroscience (Mestrado integrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2009 - Atual	Journal Club	Neuroscience	Universidade de Lisboa Faculdade de Medicina, Portugal
2020/09/29 - 2020/09/29	Neurotrophic factors: key molecules for neuronal survival and plasticity-new drug and new biomarker	Pharmaceutical Sciences (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/07/09 - 2020/07/09	Pharmacokinetic considerations for drugs acting in the Central Nervous System	Advances in Neuropharmaceutic (Curso de doutoramento (conclusão de unidades curriculares))	Universidade de Lisboa Faculdade de Farmácia, Portugal
2018/09 - 2018/09	What is epilepsy and how to act in a crisis situation	Lecture / Training Action	Colégio de São Filipe, Portugal
2018/04/20 - 2018/04/22	Basic principles of pharmacokinetics	Course: Pharmacological treatment of epilepsies (Curso de Especialização Tecnológica)
2013 - 2018	LTP in aging	Biopharmaceutical Sciences (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	Biological bases of memory and brain aging	Psicopatology (Mestrado integrado)	Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2016	Pharmacokinetics and Pharmacodinamics	Clinical pharmacology workshop for children and adolescents (Pós-doutoramento)	Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2016	Age-related alterations of fine control of neuronal communication	EIT-Health Ageing Brain summerschool	The University Medical Center, Países Baixos
2015 - 2015	Pharmacokinetics of newborn at 18 years	Clinical pharmacology workshop for children and adolescents (Pós-doutoramento)	Universidade de Lisboa Faculdade de Medicina, Portugal
2014 - 2014	Pharmacokinetics	Workshop para Internos de Anestesia (Especialização pós-licenciatura)	Hospital de Santa Maria, Portugal
2012 - 2013	Pharmacokinetics and Pharmacogenomics	Biomedical engineering (Mestrado integrado)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2013	Pharmacokinetics and Pharmacogenomics	Electrical and Computer Engineering (Mestrado integrado)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2013	Pharmacokinetics and Pharmacogenomics	Biological Engineering (Mestrado integrado)	Universidade de Lisboa Instituto Superior Técnico, Portugal
2010 - 2013	Pharmacokinetics	Diagnostic Techniques and Cardiovascular Intervention (Mestrado)	Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2009 - 2012	Free Experimental Course in Neuroscience		Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2012	Neurotrophic factors	Biochemistry (Mestrado integrado)	Universidade de Lisboa Faculdade de Ciências, Portugal
2009 - 2010	Pharmacokinetics	Clinical Investigation (Mestrado)	Keypoint, Portugal
2009 - 2009	Pharmacokinetics	Postgraduate studies	Keypoint, Portugal
2008 - 2009	Synaptic Plasticity	Biochemistry (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2020/02	Interview in the context of the investigation in Alzheimer's disease	Visão Saúde
2018/11/11	Interview in the context of the investigation in Alzheimer's disease	Diário de Notícias
2017/12/01	Report within the scope of the award of the Mantero Belard Prize of Santa Casa da Misericórdia de Lisboa	Público
2017/12/01	Report within the scope of the award of the Mantero Belard Prize of Santa Casa da Misericórdia de Lisboa	Jornal de Notícias
2017/12/01	Report within the scope of the award of the Mantero Belard Prize of Santa Casa da Misericórdia de Lisboa	Diário de Notícias
2017/11/30	Report within the scope of the award of the Mantero Belard Prize of Santa Casa da Misericórdia de Lisboa	Correio da Manhã

Entrevista / Programa (rádio / tv)

	Programa	Tema
2019/11/01 - 2019/11/01	Casos Singulares - T1, E006	Síndrome de Rett

Membro de associação

	Nome da associação	Tipo de participação
2018 - Atual	Aging and Dementia Study Group (Grupo de Estudos de Envelhecimento e Demência-GEED)	Member
2015 - Atual	Mind-Brain College of the University of Lisbon	Member
2014 - Atual	Association for Research and Development at FMUL	Member
2002 - Atual	Portuguese Society of Pharmacology	Member
2002 - Atual	Portuguese Society of Neuroscience	Member
2002 - Atual	Federation of European Neuroscience Societies	Member
2001 - Atual	Order of Pharmacists, Portugal	Member
2005 - 2010	Society for Neuroscience, United States of America	Member

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2017 - Atual	Arbitration of the Edgar Cruz e Silva Scholarship, being an integral part of the Aging and Dementia Study Group	Santa Casa da Misericórdia de Lisboa, Portugal
2009 - Atual	Grant Evaluator of the American Alzheimer’s Association	Alzheimer’s Association Greater Missouri Chapter, Estados Unidos
2009 - Atual	Project Evaluator / Presentation of works by the Support Office for Scientific, Technological and Innovation Research (Gabinete de APoio à Investigação Científica, tecnológica e inovação-GAPIC)	Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2019	Member of the Jury of the Special Competition for Access to the Medical Course by Holders of the Degree of Licensee	Universidade de Lisboa Faculdade de Medicina, Portugal
2018/10/24 - 2018/10/24	Views in Medical Education jury, 5th Edition Beyond MEd	Universidade de Lisboa Faculdade de Medicina, Portugal
2016 - 2016	Maria Filipe Canas de Matos e Oliveira Ribeiro's Advanced Training Exam	Universidade de Lisboa Faculdade de Farmácia, Portugal

Tutoria

	Tópico	Nome do aluno
2019 - Atual	Biochemistry	Mafalda Ferreira Manso
2016 - 2017	Alzheimer's disease biomarkers: Knowing the present to understand the future	Filipe Huberto Rodrigues Carralves
2015 - 2016	Laboratory rotation	Catarina Borges
2014 - 2015	Laboratory rotation	Rafaela Policarpo
2014 - 2015	Laboratory rotation	Ana Rafaela Oliveira
2014 - 2015	Laboratory rotation	Agnes Davidson
2014 - 2015	Laboratory rotation	Aylin Cetinkaya
2013 - 2014	Laboratory rotation	Anna Ganajova
2013 - 2014	Role of PSB 0777 ammonium salt and mir-122a, as potential regulators of synaptic response in Rett Syndrome	Shikha Batuk Raikundalia
2013 - 2014	Laboratory rotation	Alad Belhaj

Distinções

Prémio

2021	Mantero Belard 2021
2017	Mantero Belard Neurosciences Award Santa Casa da Misericórdia de Lisboa, Portugal
2013	Exploratory project Fundação para a Ciência e a Tecnologia, Portugal
2012	Bial scholarship Bial, Portugal
2010	First prize: Best poster- Duque do Vale, R., Lopes, L.V., Ribeiro, J.A., Sebastião, A.M., de Mendonça, A., Diógenes ,M.J. Detailing the age-related effects of memantine on long-term potentiation., YES meeting, Porto, Portugal, September 24-26, 2010
2010	1st prize (Best research work)
2001	Best work about the liver Universidade de Lisboa Faculdade de Farmácia, Portugal

Outra distinção

2020	Distinction in the Book "Pessoas & Causas" Santa Casa da Misericórdia de Lisboa, Portugal
2019	Tribute in the book "Mulheres na Ciência" Ciência Viva, Portugal