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António Francisco Ambrósio (AFA) is Coordinator Investigator/Full Professor at the Fac. Medicine, Univ. Coimbra (FMUC), Portugal. He is the Head of Retinal Dysfunction and Neuroinflammation Lab at Coimbra Institute for Clinical and Biomedical Research (iCBR-FMUC) since 2002. AFA was the Director of iCBR between 2016 and 2021. iCBR is a member of CIBB (Center for Innovative Biomedicine and Biotechnology) consortium. Presently, AFA is member of: Scientific Council of iCBR and CIBB, Ethical Committee of the Multidisciplinary Institute for Ageing (MIA)-Portugal, Scientific Committee of the PhD Program in Health Sciences at FMUC, and member of the Board of Directors of the Collaborative Laboratory VectorB2B - Drug Developing - Association for Research in Biotechnology, representing the Univ. of Coimbra. Former professional activities include (among others): member of the Directory Board of CIBB (2016-2021); Coordinator of the Research Management Office at FMUC (2016-2019); Vice-Director for Scientific Research at FMUC (2012-2015); President, vice-President and Secretary-General of the Portuguese Biochemical Society (2005-2014); Secretary-General (2005-2007) and co-founder of the Portuguese Society for Stem Cells and Cell Therapies; President of the Portuguese Association of Biochemists (2000-2004). AFA has been deeply involved in post-graduation activities at FMUC, namely in the Master in Biomedical Research, Master in Molecular and Translational Neuroscience, and the PhD Program in Health Sciences, being in charge of the Vision Sciences area. He has supervised 10 post-docs, 25 PhD students, 30 MSc students and 31 research fellows. AFA has published 171 peer-reviewed papers, 10 book chapters, holds an H factor of 45 and has 5,618 citations (Web of Science). The total funding gathered from national and international agencies, pharmaceutical companies and research programs surpasses 5 million Euros, as Principal Investigator, in 22 major projects. Along the years AFA has established many national and international collaborations. He was also awarded the prestigious Award 'Prémio Mantero Belard - Prémios Santa Casa Neurociências' in 2015. AFA has been invited speaker in national and international meetings and seminars (more than 60 talks) and grant reviewer for national and international Foundations (Foundation for Science and Technology, Portugal; Fight for Sight, UK; Diabetes Research & Wellness Foundation, USA; National Science Centre, Poland; The Wellcome Trust, UK/DBT India Alliance; Swiss National Science Foundation; Alzheimer Nederland; German Research Foundation; French National Research Agency). Along his career he has been involved in many outreaching activities for young students and the general public. His main scientific interests are focused on retinal degenerative diseases, namely diabetic retinopathy, glaucoma, age-related macular degeneration and retinitis pigmentosa, which are leading causes of vision loss and blindness worldwide. He has been interested in elucidating the molecular and cellular mechanisms underlying retinal dysfunction and degeneration, paying particular attention to the role played by neuroinflammation mediated by microglial cells (immune cells of central nervous system), as well as to cell-cell crosstalk and neuroprotection. AFA has been interested in identifying new drug targets and developing advanced therapies for retinal diseases. Moreover, he is interested in identifying novel biomarkers of disease onset and progression for retinal degenerative diseases, namely biomarkers based on texture analysis of optical coherence tomography data, as well as in drug repurposing. His Lab uses a plethora of in vitro models, including cells derived from human induced pluripotent stem cells from patients with retinal diseases, and animal models of disease, and it has the necessary equipment for assessing in vivo retinal structure, function and visual acuity.
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Identificação

Identificação pessoal

Nome completo
António Francisco Rosa Gomes Ambrósio

Nomes de citação

  • Ambrósio, A.F.
  • António Francisco Ambrósio
  • A.F. Ambrosio
  • Ambrosio, A.F.

Identificadores de autor

Ciência ID
4E11-2573-20FE
ORCID iD
0000-0002-0477-1641

Endereços de correio eletrónico

  • afambrosio@fmed.uc.pt (Profissional)

Telefones

Telefone
  • 239480093 (Profissional)
Telemóvel
  • 938312647 (Pessoal)

Moradas

  • Azinhaga Santa Comba, Celas; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548, Coimbra, Coimbra, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B2) Utilizador elementar (A1) Utilizador independente (B2) Utilizador elementar (A1)
Francês Utilizador elementar (A2) Utilizador elementar (A2) Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A2)
Formação
Grau Classificação
2016
Concluído
 Agregação em Ciências da Saúde (Título de Agregado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"A disfunção da barreira hemato-retiniana na diabetes: mecanismos moleculares e celulares envolvidos e identificação de potenciais alvos terapêuticos para o tratamento da retinopatia diabética" (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade
2000
Concluído
 Biologia (Biologia Celular) (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mechanisms of action of antiepileptic drugs and neurotoxicity in hippocampus" (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade
1997
Concluído
 Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Role of adenosine A1 receptor on the regulation of intracellular calcium concentration and glutamate release in rat hippocampus and striatum" (TESE/DISSERTAÇÃO)
 Muito bom
1994
Concluído
 Bioquímica (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 Bom com distinção (16/20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/09 - Atual Investigador Coordenador (carreira) (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
2010/09 - 2019/09/09 Investigador principal (carreira) (Investigação) Universidade de Coimbra, Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2002/07 - 2010/09 Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Faculdade de Medicina, Portugal
2000/11 - 2002/09 Pós-doutorado (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
1997/10 - 1998/11 Assistente convidado (Docente Ensino Superior Politécnico) Escola Superior de Educação Jean-Piaget, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2002/07 - Atual Group Leader of Retinal Dysfunction and Neuroinflammation Lab Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/12 - 2021/12 Director de Unidade Orgânica Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
Universidade de Coimbra, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/04 - Atual Member of the Committee for Ethical Issues Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2019/01 - Atual Member of the Board of Directors of VectorB2B - Drug Developing - Association for Research in Biotechnology (representing the University of Coimbra) Universidade de Coimbra, Portugal
2017/01 - Atual Member of the Scientific Committee, Center for Innovative Biomedicine and Biotechnology (CIBB) Consortium (former CNC.IBILI) Universidade de Coimbra, Portugal
2016/12 - Atual Member of the Scientific Committee of Coimbra Institute for Clinical and Biomedical Research (iCBR) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/05 - Atual Member of Scientific Committee of the PhD Program in Health Sciences at Faculty of Medicine, University of Coimbra Universidade de Coimbra, Portugal
2013/02 - Atual Co-coordinator of the Strategic Development Plan for Vision Sciences at Faculty of Medicine, University of Coimbra Universidade de Coimbra, Portugal
2017/01 - 2021/12 Member of the Directory Board, Center for Innovative Biomedicine and Biotechnology (CIBB) Consortium (former CNC.IBILI) Universidade de Coimbra, Portugal
Universidade de Coimbra, Portugal
2017/06 - 2021/06 Member of the Scientific Committee at Faculty of Medicine, University of Coimbra Universidade de Coimbra, Portugal
2016/10 - 2019/09 Coordinator of Research Management Office (GGI) at Faculty of Medicine, University of Coimbra Universidade de Coimbra, Portugal
2015/06 - 2017/06 Secretary of the Assembly of the Faculty of Medicine, University of Coimbra Universidade de Coimbra, Portugal
2015/06 - 2017/06 Member of the Assembly of the Faculty of Medicine, University of Coimbra Universidade de Coimbra, Portugal
2010/03 - 2016/12 Member of the Commission for the Strategic and Scientific Coordination of Institute for Biomedical Imaging and Life Sciences (IBILI)”, Faculty of Medicine, University of Coimbra Universidade de Coimbra, Portugal
2016/06/14 - 2016/06/17 Visiting foreign labs University of Cologne, Department of Ophthalmology, Alemanha
2012/02 - 2015/09 Vice-Director for Scientific Research and Technological Development at Faculty of Medicine, University of Coimbra Universidade de Coimbra, Portugal
2012/02 - 2015/06 Member of the Scientific Committee at Faculty of Medicine, University of Coimbra Universidade de Coimbra, Portugal
2013/01 - 2014/12 President of Portuguese Biochemical Society (SPB) Sociedade Portuguesa de Bioquímica, Portugal
2009/01 - 2012/12 Vice-President of Portuguese Biochemical Society (SPB) Sociedade Portuguesa de Bioquímica, Portugal
2012/09/23 - 2012/09/29 Visiting foreign labs Københavns Universitet Center for Neuroscience, Dinamarca
2010/01 - 2012/03 Scientific consultant of Take the Wind (digital media company in the área of Health Sciences) Take the Wind, Portugal
2011/09/19 - 2011/09/22 Visiting foreign labs University College London, Institute of Ophthalmology, Reino Unido
2010/06/21 - 2010/06/25 Visiting foreign labs Universitetet i Bergen, Noruega
2005/01 - 2008/12 Secretary-General of Portuguese Biochemical Society (SPB) Sociedade Portuguesa de Bioquímica, Portugal
2008/11 - 2008/11 Credited as Coordinator Investigator for Animal Experimentation by Direcção-Geral de Alimentação e Veterinária (DGAV) Direção Geral de Alimentação e Veterinária (DGAV), Portugal
2005/01 - 2007/04 Secretary of Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC) (founding member) Sociedade Portuguesa de Células Estaminais e Terapia Celular (SPCE-TC), Portugal
2006/02 - 2006/07 Member of the Directory Board of Institute of Interdisciplinary Research (“Instituto de Investigação Interdisciplinar”-III), University of Coimbra Universidade de Coimbra, Portugal
2005/04/13 - 2005/04/17 Visiting foreign labs Amsterdam Neuroscience, Países Baixos
2000/09 - 2004/12 President of Portuguese Association of Biochemists (ANBIOQ) Associação Nacional de Bioquímicos (ANBIOQ), Portugal
2003/09/16 - 2003/09/19 Visiting foreign labs Institute of Medical Sciences, Department of Ophthalmology, Reino Unido
2002/08/15 - 2002/09/06 Visiting foreign labs Penn State College of Medicine, Estados Unidos
1998/12 - 2002/06 Teaching Assistant at Department of Zoology, Faculty of Sciences and Technology, University of Coimbra Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2001/02/19 - 2001/02/22 Visiting foreign labs Institute of Medical Sciences, Department of Ophthalmology, Reino Unido
Projetos

Bolsa

Designação Financiadores
2024/04/01 - 2026/03/31 "EYS on" gene editing for Retinitis Pigmentosa 25
Not applicable
Team member
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
 European Society of Retina Specialists
Em avaliação
2023/03/12 - 2026/03/11 Deciphering the role of Piezo1 mechanosensitive channel in microglia-mediated glaucomatous neurodegeneration
2022.01354.PTDC
Outra
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2023/01/01 - 2025/12/31 Heat-induced epithelial permeability A nanoscale-based solution for the treatment of fungal keratitis
Not applicable
Outra
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Centro Hospitalar e Universitário de Coimbra EPE
Em curso
2020/01/01 - 2024/12/31 Strategic Project - Consortium CIBB (Center for Innovative Biomedicine and Biotechnology)
UIDB/04539/2020
Investigador
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2023/07 - 2024/12 Effect of supplementation of tryptophan during pregnancy and lactation and the improvement of cognition and metabolism of the offspring from diabetic mothers
Not applicable
Outra
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Sociedade Portuguesa de Diabetologia
Em curso
2023/10/01 - 2024/09/30 MICROSPONGE for INTRAVITREAL therapy of Age-related macular degeneration and diabetic retinopathy
2023-ULabs-2922
Team member
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Em curso
2023/03/13 - 2024/08/12 N(DR)2-Eye - Ndr2 kinase: a novel player in the regulation of microglia in diabetic retinopathy
2022.06170.PTDC
Outra
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022/01/01 - 2023/06/30 Enhancing epithelial permeability: a nanotechnology-based solution for epi-on corneal cross-linking
EXPL_BIA-BQM_0042_2021
Investigador
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/10 - 2022/09 siRNAGlau - Novel therapeutics of RNA interference for glaucoma
31/SI/2017 - siRNAGlau - 39743: PHYZAT BIOPHARMACEUTICALS, LDA
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Portugal
 Agência Nacional de Inovação SA
Concluído
2018/11 - 2022/08 ExoSwitch - Understanding the switch between dry and wet AMD: role of exosomes
Not applicable
Investigador
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Global Ophthalmology Award Program (GOAP) Bayer HealthCare
Concluído
2018/08 - 2022/07 Non-invasive optical coherence tomography towards the imaging of the neurodegenerative disease: from the animal retina to the human brain
OCT4BRAIN - PTDC/EMD-EMD/28039/2017 - POCI-01-0145-FEDER-028039
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2019/09 - 2020/08 Identification of novel biomarkers of diabetic retinopathy: assessing antimicrobial peptides in tears
Investigador
Universidade de Coimbra Faculdade de Medicina
Concluído
2016/01 - 2019/12 Reactivación optogenética y neuroprotección como terapia de enfermedades neurodegenerativas de la retina
BFU2015-67139-R
Investigador
Plan Nacional I+D Ministerio de Economía y Competitividad (Espanha)
Concluído
2015/01 - 2019/12 Projeto Estratégico do Consórcio CNC.IBILI
FCT-UID/NEU/04539/2013
FCT-UID/NEU/04539/2019
Investigador
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/07 - 2019/06 Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma
PTDC/NEU-OSD/3123/2014
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2016/01 - 2018/12 The changing brain in Alzheimer’s disease: is the retina a reliable mirror of disease onset and progression?
MB-1049-2015
Investigador responsável
Santa Casa da Misericórdia de Lisboa
Concluído
2015/12 - 2018/02 Managing inflammation in diabetic retinopathy by adenosine A2A receptor blockade
US2083156314
Investigador
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Global Ophthalmology Award Program (GOAP) Bayer HealthCare
Concluído
2013/05 - 2015/08 Neuropeptide Y system: a new potential therapeutic target in diabetic retinopathy
PTDC/NEU-OSD/1113/2012
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013/06/01 - 2015/05 From neuroinflammation control to neuroprotection: blocking adenosine A2A receptor for the treatment of glaucoma
PTDC/BIM-MEC/0913/2012
Investigador
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013/06 - 2015/05 Methylphenidate and blood-brain barrier changes in health and attention deficit hyperactivity disorder
PTDC/NEU-OSD/0312/2012
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2013/04 - 2014/03 Neuropeptide Y: A new potential target for retinal neuroprotection in glaucoma
n/a
Investigador
Øjenfonden
Concluído
2010/04 - 2013/09 Life and death of retinal ganglion cells: unmasking the neuromodulatory and neuroprotective roles of Neuropeptide Y
PTDC/SAU-NEU/99075/2008
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/04 - 2013/09 Impact of methamphetamine on the blood-brain barrier: unmasking the underlying mechanisms and the role of neuroinflammation
PTDC/SAU-FCF/098685/2008
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2010/04 - 2013/09 Mechanisms underlying the effects of nitric oxide on neural stem cell proliferation in brain injury
PTDC/SAU-NEU/102612/2008
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2011/11 - 2012/10 Neuropeptide Y system: a new key player and potential therapeutic target in diabetic retinopathy?"
FA0911
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Faculdade de Medicina da Universidade de Coimbra
Concluído
2010/01 - 2011/12 Retinal ganglion cell neuroprotection in models of glaucoma: identification of potential therapeutic targets
n/a
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2009/01 - 2010/12 Programa de Financiamento Plurianual do Instituto Biomédico de Investigação da Luz e Imagem (IBILI)
n/a
Investigador
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/06 - 2010/12 Regulation of AMPA receptors by hyperglycemia in the retina
PTDC/SAU-NEU/71228/2006
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/05 - 2010/09 Neuropeptide Y in the retina: Why? What for?
PTDC/SAU-NEU/73119/2006
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2005/03 - 2008/08 ATP and diabetic retinopathy: role on microglia regulation and on neuronal cell death
POCTI/SAU-NEU/59003/2004
Investigador
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2002/10 - 2005/12 Mechanisms of cell degeneration in diabetic retinopathy
POCTI/CBO/38545/2001
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2001/04 - 2004/12 Neurotoxicity mediated by AMPA and kainate receptors in the hippocampus: role of nitric oxide
POCTI/NSE/35875/99
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2000/10 - 2003/09 Mechanisms of presynaptic kainate receptor inhibition of glutamate and GABA release: role in epileptogenesis
POCTI/BCI/36491/99
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
1996/10 - 1999/12 Presynaptic receptors: high affinity kainate receptors in the hippocampus
PRAXIS/2/2.1/SAU/348/95
Investigador
Junta Nacional de Investigação Científica e Tecnológica
Concluído

Projeto

Designação Financiadores
2020/01 - 2026/12 Multidisciplinary Institute for Ageing
H2020-WIDESPREAD-2018-01 - 857524
Investigador
Comissão Europeia - H2020
2024/01/29 - 2024/04/30 Efficacy study in an ex vivo model of corneal wound healing
Not applicable
Investigador responsável
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Em curso
2015/01 - 2022/12 Morphological and functional evaluation of the retina and choroid in an animal model of diabetes
OA0196.A NOVARTIS
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Novartis Pharma AG
Concluído
2017/01 - 2021/12 BRAINHEALTH 2020
BRAINHEALTH 2020 - (CENTRO-01-0145-FEDER-000008)
Investigador
Centro 2020 - Programa Operacional Regional
Concluído
2015/07 - 2021/03 Enhancing Research in Ageing at the University of Coimbra - ERA@UC
ERAatUC-669088
Investigador
Comissão Europeia - H2020
Concluído
2019/06 - 2020/12 Evaluation of the effects of a FAAH inhibitor on the retina
Not applicable
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Portugal
 Laboratórios Bial
Concluído
2018/03 - 2019/02 New links between tears composition and diabetic retinopathy
n/a
Investigador
Sociedade Portuguesa de Diabetologia
Concluído
2015/06 - 2016/05 Multidisciplinary Institute for Ageing
MIA-664629
Investigador
Comissão Europeia - H2020
Concluído
2012/11 - 2015/10 Inhibitors of FAAH: evaluation of their potential effect on intraocular pressure and neuroprotective effect in the retina
n/a
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Laboratórios Bial
Concluído
2014/03 - 2015/02 Ageing@Coimbra: A Co-location Centre in the European Knowledge and Innovation Network for Active and Healthy Ageing
EIT-KIC/IVE/0043/2013
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2011/03 - 2014/09 DPP-IV inhibitors and GLP-1 as potential therapeutic options for the treatment of diabetic retinopathy: novel insights into the mechanisms of action
EFSD/GSK 2010
Investigador
European Foundation for the Study of Diabetes
Concluído
2013/03 - 2013/12 Unravelling hippocampal neural alterations underlying cognitive impairment in a model of insulin resistance
n/a
Investigador responsável
Sociedade Portuguesa de Diabetologia
Concluído
2012/01 - 2012/12 Characterization of endothelial cell dysfunction in the retina in type 1 diabetes animal models: potential therapeutic effects of sitagliptin
n/a
Investigador responsável
Sociedade Portuguesa de Diabetologia
Concluído
2011/03 - 2012/05 Inhibitors of FAAH (fatty acid amide hydrolase): evaluation of their potential to reduce intraocular pressure
n/a
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Laboratórios Bial
Concluído
2008/04 - 2011/03 Studies of the molecular and cellular actions of Eslicarbazepine Acetate (BIA 2-093) as compared to other anti-epileptic drugs
n/a
Investigador
Laboratórios Bial
Concluído
2008/01 - 2010/05 Identification of molecular and cellular mechanisms underlying the protective effects of calcium dobesilate in diabetic retinopathy
n/a
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Portugal
 OM Pharma SA
Concluído
2007/01 - 2008/12 Nanomedicine and new therapeutic strategies: development of supramolecular structures for the treatment of ophthalmologic diseases
n/a
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Concluído
2007/01 - 2007/04 Evaluation of the efficacy of a new formula on the prevention of cataract formation in a diabetic rat model
n/a
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Portugal
 Oystershell NV
Concluído
2006/01 - 2006/12 Retinal gene expression profiles in an experimental model for diabetic retinopathy
Not applicable
Investigador
Gelderse Blinden Stichting

Landelijke Stichting voor Blinden en Slechtzienden

Rotterdamse Vereniging Blindenbelangen
Concluído
2001/01 - 2001/12 Evaluation of L-DOPA-induced neurotoxicity and effects of COMT inhibitors
n/a
Investigador
Laboratórios Bial
Concluído
1997/10 - 1999/12 Mechanisms of action and neurotoxic/neuroprotective profile of antiepileptic drugs
n/a
Investigador
Laboratórios Bial
Concluído

Outro

Designação Financiadores
2022/09 - 2024/12 Exploratory project - Diabetic Retinopathy: from clinical to cellular phenotyping
C2C
Co-Investigador Responsável (Co-IR)
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Associação para a Investigação Biomédica e Inovação em Luz e Imagem
2022/10/01 - 2024/09/30 Eyes on Retinitis Pigmentosa 25
Not applicable
Outra
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Retina Studies Group

AbbVie Lda
Em curso
2019/09 - 2019/12 Concurso Programa de Estímulo a Projetos de Investigação Interdisciplinar e Translacional (PEPITA) para aquisição de equipamento
PEPITA 2019
Investigador responsável
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluído
2011/01 - 2014/12 Projeto Estratégico do Instituto Biomédico de Investigação da Luz e Imagem (IBILI)
PEst-C/SAU/UI3282/2011
PEst-C/SAU/UI3282/2013
Investigador
Coimbra Institute for Clinical and Biomedical Research (iCBR), Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Baptista, Filipa I.; Ambrósio, António F.. "Tracing the influence of prenatal risk factors on the offspring retina: Focus on development and putative long-term consequences". European Journal of Clinical Investigation (2024): http://dx.doi.org/10.1111/eci.14266.
    10.1111/eci.14266
  2. Martins, Beatriz; Pires, Maria; Ambrósio, António Francisco; Girão, Henrique; Fernandes, Rosa. "Contribution of extracellular vesicles for the pathogenesis of retinal diseases: shedding light on blood-retinal barrier dysfunction". Journal of Biomedical Science 31 1 (2024): http://dx.doi.org/10.1186/s12929-024-01036-3.
    10.1186/s12929-024-01036-3
  3. Santos, Paulo F.; Ambrósio, António Francisco; Léger, Hélène. "The Importance of Kinases in Retinal Degenerative Diseases". Kinases and Phosphatases 2 1 (2024): 93-109. http://dx.doi.org/10.3390/kinasesphosphatases2010006.
    10.3390/kinasesphosphatases2010006
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  130. Santiago, A. R.; Garrido, M. J.; Cristóvão, A. J.; Duarte, J. M. N.; Carvalho, R. A.; Ambrósio, A. F.. "Evaluation of the Impact of Diabetes on Retinal Metabolites by NMR Spectroscopy". Current Eye Research 35 11 (2010): 992-1001. http://dx.doi.org/10.3109/02713683.2010.500113.
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  131. Gaspar, J.M.; Baptista, F.I.; Galvão, J.; Castilho, Á.F.; Cunha, R.A.; Ambrósio, A.F.. "Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals". Neuroscience 169 4 (2010): 1589-1600. http://dx.doi.org/10.1016/j.neuroscience.2010.06.021.
    10.1016/j.neuroscience.2010.06.021
  132. Aveleira, C. A.; Lin, C.-M.; Abcouwer, S. F.; Ambrosio, A. F.; Antonetti, D. A.. "TNF-  Signals Through PKC /NF- B to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability". Diabetes 59 11 (2010): 2872-2882. http://dx.doi.org/10.2337/db09-1606.
    10.2337/db09-1606
  133. Leal, E. C.; Martins, J.; Voabil, P.; Liberal, J.; Chiavaroli, C.; Bauer, J.; Cunha-Vaz, J.; Ambrosio, A. F.. "Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes". Diabetes 59 10 (2010): 2637-2645. http://dx.doi.org/10.2337/db09-1421.
    10.2337/db09-1421
  134. Carreira, Bruno Pereira; Morte, Maria Inês; Inácio, Ângela; Costa, Gabriel; Rosmaninho-Salgado, Joana; Agasse, Fabienne; Carmo, Anália; et al. "Nitric Oxide Stimulates the Proliferation of Neural Stem Cells Bypassing the Epidermal Growth Factor Receptor". STEM CELLS (2010): N/A-N/A. http://dx.doi.org/10.1002/stem.444.
    10.1002/stem.444
  135. Aveleira, Célia; Castilho, Áurea; Baptista, Filipa; Simões, Núria; Fernandes, Carolina; Leal, Ermelindo; Ambrósio, António Francisco. "High glucose and interleukin-1ß downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism". Cytokine 49 3 (2010): 279-286. http://dx.doi.org/10.1016/j.cyto.2009.11.014.
    10.1016/j.cyto.2009.11.014
  136. Pereira, Tiago de Oliveira Simões; da Costa, Gabriel Nascimento Ferreira; Santiago, Ana Raquel Sarabando; Ambrósio, António Francisco; dos Santos, Paulo Fernando Martins. "High glucose enhances intracellular Ca2+ responses triggered by purinergic stimulation in retinal neurons and microglia". Brain Research 1316 (2010): 129-138. http://dx.doi.org/10.1016/j.brainres.2009.12.034.
    10.1016/j.brainres.2009.12.034
  137. Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia. "Neuropeptide Y inhibits [Ca2+]ichanges in rat retinal neurons through NPY Y1, Y4, and Y5receptors". Journal of Neurochemistry 109 5 (2009): 1508-1515. http://dx.doi.org/10.1111/j.1471-4159.2009.06079.x.
    10.1111/j.1471-4159.2009.06079.x
  138. Costa, G.; Pereira, T.; Neto, A.M.; Cristóvão, A.J.; Ambrósio, A.F.; Santos, P.F.. "High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures". Journal of Neuroscience Research 87 6 (2009): 1375-1380. http://dx.doi.org/10.1002/jnr.21956.
    10.1002/jnr.21956
  139. Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.; Ambrósio, António F.. "High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway". Experimental Eye Research 88 5 (2009): 983-991. http://dx.doi.org/10.1016/j.exer.2008.12.010.
    10.1016/j.exer.2008.12.010
  140. Santiago AR; Gaspar JM; Baptista FI; Cristóvão AJ; Santos PF; Kamphuis W; Ambrósio AF; et al. "Diabetes changes the levels of ionotropic glutamate receptors in the rat retina.". Molecular Vision 15 (2009): 1620-1630. http://europepmc.org/abstract/med/19693289.
  141. Santiago, Ana R.; Carvalho, Caetana M.; Carvalho, Arsélio P.; Ambrósio, António F.. "Differential Contribution of L-, N-, and P/Q-type Calcium Channels to [Ca2+]i Changes Evoked by Kainate in Hippocampal Neurons". Neurochemical Research 33 8 (2008): 1501-1508. http://dx.doi.org/10.1007/s11064-008-9618-8.
    10.1007/s11064-008-9618-8
  142. Álvaro, Ana Rita; Martins, João; Araújo, Inês M.; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia. "Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide". Journal of Neurochemistry 105 6 (2008): 2501-2510. http://dx.doi.org/10.1111/j.1471-4159.2008.05334.x.
    10.1111/j.1471-4159.2008.05334.x
  143. Álvaro, A.R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C.. "Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy". Neuroscience 152 1 (2008): 97-105. http://dx.doi.org/10.1016/j.neuroscience.2007.12.027.
    10.1016/j.neuroscience.2007.12.027
  144. Santiago, Ana R.; Hughes, John M.; Kamphuis, Willem; Schlingemann, Reinier O.; Ambrósio, António F.. "Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina". Brain Research 1198 (2008): 153-159. http://dx.doi.org/10.1016/j.brainres.2007.12.030.
    10.1016/j.brainres.2007.12.030
  145. Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Aurea F.; Baptista, Filipa I.; Ambrósio, António F.. "Müller Cells Do Not Influence Leukocyte Adhesion to Retinal Endothelial Cells". Ocular Immunology and Inflammation 16 4 (2008): 173-179. http://dx.doi.org/10.1080/09273940802204535.
    10.1080/09273940802204535
  146. Leal, Ermelindo C.; Manivannan, Ayyakkannu; Hosoya, Ken-Ichi; Terasaki, Tetsuya; Cunha-Vaz, Jose´; Ambro´sio, Anto´nio Francisco; Forrester, John V.. "Inducible Nitric Oxide Synthase Isoform Is a Key Mediator of Leukostasis and Blood-Retinal Barrier Breakdown in Diabetic Retinopathy". Investigative Opthalmology & Visual Science 48 11 (2007): 5257. http://dx.doi.org/10.1167/iovs.07-0112.
    10.1167/iovs.07-0112
  147. Araújo, I M; Carreira, B P; Pereira, T; Santos, P F; Soulet, D; Inácio, Â; Bahr, B A; et al. "Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons". Cell Death & Differentiation 14 9 (2007): 1635-1646. http://dx.doi.org/10.1038/sj.cdd.4402171.
    10.1038/sj.cdd.4402171
  148. Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al. "NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells". Neurochemistry International 50 5 (2007): 757-763. http://dx.doi.org/10.1016/j.neuint.2007.01.010.
    10.1016/j.neuint.2007.01.010
  149. Santiago, A.R.; Cristóvão, A.J.; Santos, P.F.; Carvalho, C.M.; Ambrósio, A.F.. "High glucose induces caspase-independent cell death in retinal neural cells". Neurobiology of Disease 25 3 (2007): 464-472. http://dx.doi.org/10.1016/j.nbd.2006.10.023.
    10.1016/j.nbd.2006.10.023
  150. Santiago, Ana R.; Rosa, Susana C.; Santos, Paulo F.; Cristo´va~o, Armando J.; Barber, Alistair J.; Ambro´sio, Anto´nio F.. "Elevated Glucose Changes the Expression of Ionotropic Glutamate Receptor Subunits and Impairs Calcium Homeostasis in Retinal Neural Cells". Investigative Opthalmology & Visual Science 47 9 (2006): 4130. http://dx.doi.org/10.1167/iovs.06-0085.
    10.1167/iovs.06-0085
  151. Santiago, Ana R.; Pereira, Tiago S.; Garrido, Manuel J.; Cristóvão, Armando J.; Santos, Paulo F.; Ambrósio, António F.. "High glucose and diabetes increase the release of [3H]-d-aspartate in retinal cell cultures and in rat retinas". Neurochemistry International 48 6-7 (2006): 453-458. http://dx.doi.org/10.1016/j.neuint.2005.10.013.
    10.1016/j.neuint.2005.10.013
  152. Duarte, João M.N.; Oliveira, Catarina R.; Ambrósio, António F.; Cunha, Rodrigo A.. "Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats". Neurochemistry International 48 2 (2006): 144-150. http://dx.doi.org/10.1016/j.neuint.2005.08.008.
    10.1016/j.neuint.2005.08.008
  153. Leal, E.; Santiago, A.; Ambrosio, A.. "Old and New Drug Targets in Diabetic Retinopathy: From Biochemical Changes to Inflammation and Neurodegeneration". Current Drug Target -CNS & Neurological Disorders 4 4 (2005): 421-434. http://dx.doi.org/10.2174/1568007054546162.
    10.2174/1568007054546162
  154. Araújo, I.M.; Verdasca, M.J.; Leal, E.C.; Bahr, B.A.; Ambrósio, A.F.; Carvalho, A.P.; Carvalho, C.M.. "Erratum: Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons (Journal of Neurochemistry (2004) 91 (1322-1331))". Journal of Neurochemistry 92 4 (2005): 996-996. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644260452&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2004.03043.x
  155. Araujo, Ines M.; Ambrosio, Antonio Francisco; Leal, Ermelindo C.; Verdasca, Maria Joao; Malva, Joao Oliveira; Soares-da-Silva, Patricio; Carvalho, Arselio Pato; Carvalho, Caetana Monteiro. "Neurotoxicity Induced by Antiepileptic Drugs in Cultured Hippocampal Neurons: A Comparative Study between Carbamazepine, Oxcarbazepine, and Two New Putative Antiepileptic Drugs, BIA 2-024 and BIA 2-093". Epilepsia 45 12 (2004): 1498-1505. http://dx.doi.org/10.1111/j.0013-9580.2004.14104.x.
    10.1111/j.0013-9580.2004.14104.x
  156. Araújo, Inês M.; Verdasca, Maria J.; Leal, Ermelindo C.; Bahr, Ben A.; Ambrósio, António F.; Carvalho, Arsélio P.; Carvalho, Caetana M.. "Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons". Journal of Neurochemistry 91 6 (2004): 1322-1331. http://dx.doi.org/10.1111/j.1471-4159.2004.02811.x.
    10.1111/j.1471-4159.2004.02811.x
  157. Araújo, Inês M.; Verdasca, Maria J.; Ambrósio, António F.; Carvalho, Caetana M.. "Nitric oxide inhibits complex I following AMPA receptor activation via peroxynitrite". NeuroReport 15 13 (2004): 2007-2011. http://dx.doi.org/10.1097/00001756-200409150-00003.
    10.1097/00001756-200409150-00003
  158. Malva, João Oliveira; Vieira, Ana P.; Ambrósio, António F.; Oliveira, Catarina R.. "Cobalt staining of hippocampal neurons mediated by non-desensitizing activation of AMPA but not kainate receptors". NeuroReport 14 6 (2003): 847-850. http://dx.doi.org/10.1097/00001756-200305060-00014.
    10.1097/00001756-200305060-00014
  159. Araújo IM; Ambrósio AF; Leal EC; Santos PF; Carvalho AP; Carvalho CM; Araújo, I.M.; et al. "Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide in kainate-induced neurotoxicity in hippocampal neurons.". Journal of Neurochemistry 85 3 (2003): 791-800. http://europepmc.org/abstract/med/12694405.
    10.1046/j.1471-4159.2003.01731.x
  160. Ambrósio, António F.; Soares-da-Silva, Patrício; Carvalho, Caetana M.; Carvalho, Arsélio P.; Ambrósio, A.F.; Soares-da-Silva, P.; Carvalho, C.M.; Carvalho, A.P.. "Mechanisms of action of carbamazepine and their derivatives, oxcarbazepine, BIA 2-093 and BIA 2-024". Neurochemical Research 27 1/2 (2002): 121-130. http://dx.doi.org/10.1023/a:1014814924965.
    10.1023/a:1014814924965
  161. Silva, Ana P.; Malva, João O.; Ambrósio, António F.; Salgado, António J.; Carvalho, Arsélio P.; Carvalho, Caetana M.. "Role of kainate receptor activation and desensitization on the [Ca2+]ichanges in cultured rat hippocampal neurons". Journal of Neuroscience Research 65 5 (2001): 378-386. http://dx.doi.org/10.1002/jnr.1164.
    10.1002/jnr.1164
  162. Ambrósio, António F.; Silva, Ana P.; Malva, João O.; Soares-da-Silva, Patricio; Carvalho, Arsélio P.; Carvalho, Caetana M.; Ambrósio, A.F.; et al. "Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels11Abbreviations: AED, antiepileptic drug; CBZ, carbamazepine; OXC, oxcarbazepine; and 4-AP, 4-aminopyridine.". Biochemical Pharmacology 61 10 (2001): 1271-1275. http://dx.doi.org/10.1016/s0006-2952(01)00584-6.
    10.1016/s0006-2952(01)00584-6
  163. Ambrósio, António F; Silva, Ana P; Araújo, Inês; Malva, João O; Soares-da-Silva, Patri´cio; Carvalho, Arsélio P; Carvalho, Caetana M. "Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024". European Journal of Pharmacology 406 2 (2000): 191-201. http://dx.doi.org/10.1016/s0014-2999(00)00659-2.
    10.1016/s0014-2999(00)00659-2
  164. Ambrósio, António F.; Silva, Ana P.; Malva, João O.; Mesquita, José F.; Carvalho, Arsélio P.; Carvalho, Caetana M.. "Role of desensitization of AMPA receptors on the neuronal viability and on the [Ca2+]ichanges in cultured rat hippocampal neurons". European Journal of Neuroscience 12 6 (2000): 2021-2031. http://dx.doi.org/10.1046/j.1460-9568.2000.00091.x.
    10.1046/j.1460-9568.2000.00091.x
  165. Ambrósio, António F.; Silva, Ana P.; Malva, João O.; Soares-da-Silva, Patri´cio; Carvalho, Arsélio P.; Carvalho, Caetana M.; Ambrósio, A.F.; et al. "Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists". Neuropharmacology 38 9 (1999): 1349-1359. http://dx.doi.org/10.1016/s0028-3908(99)00058-1.
    10.1016/s0028-3908(99)00058-1
  166. Malva, J; Ambrósio, A.F.. "Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channels". Neurochemistry International 32 1 (1998): 7-16. http://dx.doi.org/10.1016/s0197-0186(97)00048-x.
    10.1016/s0197-0186(97)00048-x
  167. Ambrósio, António F; Malva, João O; Carvalho, Arsélio P; Carvalho, Caetana M. "Inhibition of N-, P/Q- and other types of Ca2+ channels in rat hippocampal nerve terminals by the adenosine A1 receptor". European Journal of Pharmacology 340 2-3 (1997): 301-310. http://dx.doi.org/10.1016/s0014-2999(97)01451-9.
    10.1016/s0014-2999(97)01451-9
  168. Sequeira, Sónia M.; Ambrósio, António F.; Malva, João O.; Carvalho, Arsélio P.; Carvalho, Caetana M.. "Modulation of Glutamate Release from Rat Hippocampal Synaptosomes by Nitric Oxide". Nitric Oxide 1 4 (1997): 315-329. http://dx.doi.org/10.1006/niox.1997.0144.
    10.1006/niox.1997.0144
  169. Ambrósio, António F.; Malva, João O.; Carvalho, Arsélio P.; Carvalho, Caetana M.. "Modulation of Ca2+ channels by activation of adenosine A1 receptors in rat striatal glutamatergic nerve terminals". Neuroscience Letters 220 3 (1996): 163-166. http://dx.doi.org/10.1016/s0304-3940(96)13252-3.
    10.1016/s0304-3940(96)13252-3
  170. Malva, Joa˜o O.; Ambrósio, António F.; Carvalho, Arsélio P.; Duarte, Carlos B.; Carvalho, Caetana M.. "Involvement of class A calcium channels in the KCl induced Ca2+ influx in hippocampal synaptosomes". Brain Research 696 1-2 (1995): 242-245. http://dx.doi.org/10.1016/0006-8993(95)00816-9.
    10.1016/0006-8993(95)00816-9
  171. Malva, J.O.; Ambrósio, A.F.; Cunha, R.A.; Ribeiro, J.A.; Carvalho, A.P.; Carvalho, C.M.; Malva, João O.; et al. "A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion". Neuroscience Letters 185 2 (1995): 83-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912732&partnerID=MN8TOARS.
    10.1016/0304-3940(94)11230-G
Artigo em revista (magazine)
  1. J. Martins; M. Castelo-Branco; A. Batista; B. Oliveiros; A.R. Santiago; J. Galvão; E. Fernandes; et al. "Consumo de ecstasy influencia visão?", ÓpticaPro, 2012
Capítulo de livro
  1. A.F. Ambrosio. "Nanotools for the Treatment of Ocular Diseases (Chapter 7)". In Nanomaterials and Nanotechnology in Medicine, 169-184. John Wiley & Sons Ltd, 2023.
    Publicado
  2. Bernardes, Rui; Silva, Gilberto; Chiquita, Samuel; Serranho, Pedro; Ambrósio, António Francisco. "Retinal Biomarkers of Alzheimer’s Disease: Insights from Transgenic Mouse Models". In Image Analysis and Recognition, 541-550. Springer International Publishing, 2017.
    10.1007/978-3-319-59876-5_60
  3. A.R. Santiago; M. Castelo-Branco; Ambrósio, António. "Sistema Visual". In Neurociências, editado por A.C. Rego; C.B. Duarte; C.R. Oliveira, 325-348. Lidel, 2017.
    Publicado
  4. Palavra, F.; Ambrósio, A.F.; Reis, F.; F. Palavra; Ambrósio, António; F. Reis. "mTOR and Neuroinflammation". In Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies, editado por K. Maiese, 317-329. Elsevier Science & Technology Books and Academic Press, 2016.
  5. E.C. Leal; Ambrósio, António; J. Cunha-Vaz; Leal, E.C.; Ambrósio, A.F.; Cunha-Vaz, J.. "Nitric oxide synthase in retinal vascular diseases". In Studies on retinal and choroidal disorders: Oxidative stress in applied basic research and clinical practice, editado por R.D. Stratton; W.W. Hauswirth; T.W. Gardner, 529-544. Springer Science & Business Media, 2012.
    Publicado
  6. Ambrósio, António. "Cell factors". In Diabetic Retinopathy, editado por J. Cunha-Vaz, 143-152. World Scientific, 2011.
    Publicado
  7. E.C. Leal; Ambrósio, António. "Neovascularization in Diabetic Retinopathy". In Diabetic Retinopathy, editado por J. Cunha-Vaz, 143-152. World Scientific, 2011.
    Publicado
  8. Ambrósio, A.F.; Pereira, P.; Vaz, J.-C.; Ambrósio, António; P. Pereira; J. Cunha-Vaz. "Diabetic retinopathy, inflammation, and proteasome". In Interaction between neurons and glia in aging and disease, editado por J.O. Malva; A.C. Rego; R.A. Cunha; C.R. Oliveira, 475-502. New York, Estados Unidos: Springer-Verlag, 2007.
    Publicado
  9. Ambrósio, António. "Factores celulares". In Retinopatía Diabética, editado por J. Cunha-Vaz, 136-150. Madrid, Espanha: Sociedad Española de Oftalmología, 2006.
    Publicado
  10. E.C. Leal; Ambrósio, António. "La neovascularización en la Retinopatía Diabética". In Retinopatía Diabética, editado por J. Cunha-Vaz, 150-159. Madrid, Espanha: Sociedad Española de Oftalmología, 2006.
    Publicado
Tese / Dissertação
  1. Ambrósio, António. "Mechanisms of action of antiepileptic drugs and neurotoxicity in hippocampus". Doutoramento, Universidade de Coimbra, 2000.
  2. Ambrósio, António. "Role of adenosine A1 receptor on the regulation of intracellular calcium concentration and glutamate release in rat hippocampus and striatum". Mestrado, Universidade de Coimbra, 1997.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/06/02 Non-canonical anti-inflammatory effects of sitagliptin on (retinal) microglia. 33rd EAsDEC (European Association for Diabetic Eye Complications) Meeting
European Association for Diabetic Eye Complications (Coimbra, Portugal)
2022/10 The retina as a window to the brain in Alzheimer's disease? Insights from an animal model. 23rd EVER Congress
European Association for Vision and Eye Research (EVER) (Valencia, Espanha)
2022/09/22 Doenças degenerativas da retina: mecanismos de doença, terapias e biomarcadores. IV Simpósio em Bioquímica Aplicada
Universidade do Minho (Braga, Portugal)
2022/02/23 The retina as a window to the brain in Alzheimer's disease? Insights from an animal model - EVER Electrophysiology / physiological Optics / Vision Sciences Webinar - The Retina as a Window into the Brain EVER Electrophysiology / physiological Optics / Vision Sciences Webinar - The Retina as a Window into the Brain
European Association for Vision and Eye Research
2021/05/29 A retina como uma janela para o cérebro? Evidências num modelo animal de doença de Alzheimer XXI Congresso Nacional de Ortoptistas
Associação Portuguesa de Ortoptistas (Figueira da Foz, Portugal)
2021/05 The retina as a window to the brain? Evidences from an animal model of Alzheimer's disease. XXI Congresso Nacional de Ortoptistas - VI Congresso Luso Brasileiro de Ortóptica
Associação Portuguesa de Ortoptistas (Figueira da Foz, Portugal)
2019/12/09 Invited Speaker - Alzheimer’s disease: the retina as a window or mirror of the brain? II Luso-Brazilian Symposium on Neurosciences and III International Symposium in Neurosciences"
(Fortaleza, Brasil)
2019/04/29 Retinal thinning of inner layers is associated with visual cortex atrophy in a mouse model of Alzheimer’s disease: a longitudinal in vivo multimodal study. ARVO 2019 Annual Meeting
(Vancouver, Canadá)
2018/09/12 Invited Speaker - Is the retina a reliable window to look into the brain in Alzheimer’s disease? XXIII Biennial Meeting of the International Society for Eye Research
(Belfast, Irlanda)
2018/06/30 Invited Speaker - Targeting microglial A2AR to reduce AMD-related inflammatory processes VI International Congress of Research in Retina and Vision (SIREV)
(Madrid, Espanha)
2018/06/20 Invited Speaker - Targeting adenosine receptors for the treatment of retinal degenerative diseases. Purines 2018 International
(Foz do Iguaçu, Brasil)
2017/12/15 Invited Speaker - The research management office: the way to leverage your research! ONCONET SUDOE: ONCO Emergence Forum
(Montpellier, França)
2017/07/04 Doenças oculares: Identificação de novos alvos terapêuticos e desenvolvimento de terapias avançadas Ciência 2017 - Encontro com a Ciência e Tecnologia em Portugal
(Lisboa, Portugal)
2017/05/24 Treatment of retinal degenerative diseases: targeting neuroinflammation? II Symposium of the Portuguese Glial Network
(Braga, Portugal)
2016/12/10 Invited Speaker - Um Programa Nacional de Investigação em Retina 59º Portuguese Congress of Ophthalmology
(Coimbra, Portugal)
2016/12/02 Treatment with an A2A receptor antagonist reduces neuroinflammation and protects the retina against ischemic damage 13th ISOPT Clinical - The International Symposium on Ocular Pharmacology & Therapeutics
(Rome, Itália)
2016/09/09 Invited Speaker - The changing brain in Alzheimer’s disease: is the retina a reliable mirror of disease onset and progression? Conferências Santa Casa Neurociências: Doenças Neurodegenerativas Associadas ao Envelhecimento
(Lisboa, Portugal)
2016/07/01 Invited Speaker - Targeting adenosine A2A receptors for the treatment of retinal degenerative diseases? V SIRCOVA International Congress
(Valencia , Espanha)
2015/12/14 Invited Speaker - Caffeine: dissecting its protective effects in retinal degenerative diseases Day of Faculty of Medicine
(Coimbra, Portugal)
2015/08/25 Invited Speaker - Targeting microglia to treat retinal degenerative diseases 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology
(Foz do Iguaçu, Brasil)
2014/09/02 Sodium-vitamin C co-transporter-2 (SVCT-2) regulates the activation of microglial cells. FEBS-EMBO 2014 Conference
(Paris, França)
2014/06/20 Adenosine A2A receptor blockade and cafeine prevent retinal neuroinflammation and retinal ganglion cell death 11th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT) - Clinical
(Reykjavik, Islândia)
2014/03/14 Invited Speaker - The role of neuroinflammation in retinal degenerative diseases: microglia as a potential therapeutic target 2nd Symposium of Pathophysiology of Glial Cell
(Salvador da Bahia, Brasil)
2014/03/12 Invited Speaker - The role of neuroinflammation in retinal degenerative diseases: microglia as a potential therapeutic target I Symposium of the Portuguese-Brazilian Glial Network
(Rio de Janeiro, Brasil)
2013/11/13 Neurochemical changes in retinal degenerative diseases: targeting neuropeptide Y as a potential therapeutic strategy XII PABMB Congress
(Puerto Varas, Chile)
2013/10/03 Effects of high glucose and interleukin-1ß in the different retinal neural cells in culture European Retina Meeting 2013
(Alicante, Espanha)
2013/09/20 Neuropeptide Y Y1 receptor is neuroprotective and modulates microglia reactivity in the rat retina. EVER 2013
(Nice, França)
2013/09/05 Neuropeptide Y protects ganglion cells against excitotoxicity and modulates microglia activation in the rat retina. ARVO-ISOCB: Ocular Cell Biology Conference 2013
(Oxford, Reino Unido)
2013/07/10 Invited Speaker - New potential molecular targets to treat ocular diseases 38th FEBS Congress
(St Petersburg, Rússia)
2013/03/05 Adenosine A3 receptor agonist prevents retinal ganglion cell degeneration 10th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT) - Clinical
(Paris, França)
2013/03/02 Invited Speaker - Impact of diabetes in the retina and hippocampus Reunião Anual da Sociedade Portuguesa de Diabetologia
(Tomar, Portugal)
2013/02/08 Invited Speaker - Diabetes and blood-retinal barrier breakdown: role of inflammatory mediators and strategies to control neuroinflammation Beating the Blood-Brain & Other Blood Barriers
(Lisboa, Portugal)
2012/06/01 Anti-inflammatory and neuroprotective strategies to treat retinal degenerative diseases. Oral communication at “Inter-University Doctoral Programme in Ageing and Degeneration of Complex Biological Systems (PhDESC) Retreat
(Vila Praia de Âncora, Portugal)
2012/03/17 Invited Speaker - The importance of animal and in vitro models in the development of new therapies to treat retinal degenerative diseases Portuguese Meeting of Visual Rehabilitation
(Aveiro, Portugal)
2011/11/29 Invited Speaker - Neuroinflammation control: strategies to treat degenerative diseases of the retina III Neuroscience Symposium
(Niteiró, Brasil)
2011/11/05 Invited Speaker - Unravelling the protective effects of calcium dobesilate against the blood-retinal barrier breakdown triggered by diabetes. II SIRCOVA Meeting - Sociedad de Investigación de Retina de la Comunidad Valenciana
(Valencia, Espanha)
2011/05/30 Invited Speaker - Unravelling the protective effects of calcium dobesilate against the blood-retinal barrier breakdown triggered by diabetes Barrier Systems in Health and Disease
(Lisboa, Portugal)
2011/04/29 Invited Speaker - PKCzeta: a novel target to prevent the blood-retinal barrier breakdown? 5th Annual Meeting on Cell Signalling
(Coimbra, Portugal)
2011/02/03 Inhibition of inflammation and oxidative/nitrosative stress in the retina of diabetic rats by calcium dobesilate. XLI Annual Meeting of the Portuguese Society of Pharmacology
(Coimbra, Portugal)
2010/12/15 Invited Speaker - Pro-inflammatory mediators in diabetic retinopathy: molecular determinants of blood-retinal barrier breakdown. XVII Congresso Nacional de Bioquímica
(Porto, Portugal)
2010/12/07 Invited Speaker - Calcium dobesilate and diabetic retinopathy: understanding the mechanisms of action of an old drug II Neuroscience Symposium and III Portuguese-Brazilian Colloquium on Neurochemistry
(Niterói, Brasil)
2010/10/07 Mechanisms underlying the protective e¿ects of calcium dobesilate against the breakdown of blood-retinal barrier induced by diabetes European Association for Vision and Eye Research - EVER 2010
(Creta, Grécia)
2009/12/12 Invited Speaker - Diabetic retinopathy and the breakdown of blood-retinal barrier: identification of key players and potential treatments Ist Annual Meeting of IBILI
(Coimbra, Portugal)
2009/09/17 Invited Speaker - Understanding the dual face of diabetic retinopathy: microvascular and neural dysfunction XIII Congreso de la Sociedad Española de Neurociencia
(Tarragona, Espanha)
2008/10/04 Invited Speaker - Role of inflammation in blood-retinal barrier breakdown: animal models European Association for Vision and Eye Research - EVER 2008
(Portoroz, Eslovénia)
2008/10/01 Invited Speaker - The action of pro-inflammatory cytokines on retinal endothelial cell barrier permeability: protective effect of corticosteroids European Association for Vision and Eye Research - EVER 2008
(Portoroz, Eslovénia)
2008/09/04 Invited Speaker - Diabetic retinopathy: inside and beyond microvascular dysfunction II Portuguese-Brazilian Colloquium on Neurochemistry
(Búzios, Brasil)
2008/09/04 Invited Speaker - Impact of hyperglycemia on AMPA receptors in the retina I Congresso IBRO/LARC de Neurociências da América Latina, Caribe e Peninsula Ibérica
(Búzios, Brasil)
2008/05/31 Invited Speaker - Endothelial and neuronal cell death in diabetic retinopathy II Colóquio do Departamento das Ciências Laboratoriais Aplicadas na Saúde –Novas Terapias para Velhas Doenças
(Coimbra, Portugal)
2006/10/20 Invited Speaker - Anti-inflammatory drugs as a novel therapeutic strategy to treat diabetic retinopathy? 14th Mainzer Forum: Medicinal Chemistry, Neuroinflammation and Therapeutic Strategies
(Mainz, Alemanha)
2006/09/28 Invited Speaker - Cell factors in diabetic retinopathy 82 Congreso de la Sociedad Española de Oftalmología
(La Coruna, Espanha)
2006/09/10 Leukostasis and blood-retinal barrier breakdown are regulated by constitutive and inducible nitric oxide synthase isoforms in diabetic retinopathy 9th International Symposium, Signal Transduction in the Blood-Brain Barriers
(Salzburg, Áustria)
2005/10/21 Invited Speaker - Diabetic Retinopathy - Endothelial dysfunction AIBILI-IBILI Meeting
(Coimbra, Portugal)
2005/06/23 Invited Speaker - Leukocyte adhesion and blood-retinal barrier breakdown in diabetic retinopathy (DR): role of nitric oxide (NO) XV International Meeting of Ophthalmology
(Coimbra, Portugal)
2005/05/28 Invited Speaker - The involvement of nitric oxide in leukocyte adhesion and blood-retinal barrier breakdown 15th Meeting of the European Association for the Study of Diabetes – Eye Complications Study Group (EASDec)
(Coimbra, Portugal)
2005/05/20 Inhibition of nitric oxide synthase prevents leukocyte adhesion and blood-retinal barrier breakdown in diabetic retinas 9th Meeting of the Portuguese Society for Neurosciences
(Luso, Portugal)
2004/07/01 Invited Speaker - Blood-retinal barrier and neuroglial changes Center of Ophthalmology Day
(Coimbra, Portugal)
2004/02/15 Invited Speaker - The blood-retinal barrier 2nd International University Program on the Role of Ischemia in Eye Diseases - Retinal degeneration and ischemia
(Coimbra, Portugal)
2003/07/04 Invited Speaker - Neuronal and vascular degeneration in diabetic retinopathy XII International Meeting of Ophthalmology
(Coimbra, Portugal)
2002/07/04 Invited Speaker - Mechanisms of cell degeneration in diabetic retinopathy XII International Meeting of Ophthalmology
(Coimbra, Portugal)
2001/09/14 Invited Speaker - AMPA and kainate receptors: two players in [Ca2+]i changes and neuronal degeneration 7th Meeting of the Portuguese Society for Neuroscience
(Luso, Portugal)
1999/09/08 Effect of blocking desensitization of AMPA receptors on the neurotoxicity and on the [Ca2+]i changes induced by AMPA or kainate 6th Meeting of the Portuguese Society for Neurosciences
(Lisboa, Portugal)
1999/04/09 Inhibition of L-type Ca2+ channels by carbamazepine in cultured rat hippocampal neurons stimulated with ionotropic glutamate receptor agonists Joint Meeting of British Pharmacological Society and Portuguese Society of Pharmacology
(Porto, Portugal)
1997/11/11 Inhibition of N-, P/Q- and other non-identified type of Ca2+ channels in rat hippocampal nerve terminals by adenosine A1 receptor activation I Congress of Research in Medicine
(Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018 - Atual Putative role of microglia dimorphism in schizophrenia gender gender differences
Coorientador de Ana Catarina Rodrigues Neves
 PhD in Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2021/01/01 - 2024/12/31 Texture analysis of optical coherence tomography retinal images as a novel and early predictor of diabetic retinopathy onset and progression
Orientador
 Health Sciences - Biomedical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/01/01 - 2024/12/31 Retinal pigment epithelial cell-derived extracellular vesicles: possible role in the switch between dry and wet age-related macular degeneration
Coorientador
 Health Sciences - Biomedical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2021/09/01 - 2024/08/31 Dissecting retinal alterations in Attention-Deficit/Hyperactivity Disorder and the therapeutic and misuse effects of methylphenidate
Coorientador
 Health Sciences - Biomedical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2022/09/01 - 2023/09/25 Dissecting the mechanisms underlying the anti-inflammatory effects of sitagliptin on microglial cells
Orientador
 Biomedical Engineering (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2022/07/01 - 2023/09/22 Prenatal stress and long-term effects on retinal vulnerability to disease: role of microglia immune priming
Coorientador
 Medicinal Chemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/09 - 2022/09 Impact of maternal diabetes on offspring retinal structure and function
Coorientador
 Master in Biomedical Engineering (Mestrado)
Universidade de Coimbra, Portugal
2017/09 - 2022/09 The role of aging-related microglia dysfunction in the neurodegenerative process of Machado-Joseph disease
Orientador
 PhD (Doutoramento)
Universidade do Minho, Portugal
2020/09 - 2021/12 Drug encapsulation in extracellular vesicles for age-related macular degeneration treatment
Coorientador
 Master in Biomedical Engineering (Mestrado)
2020/09 - 2021/12 Can the extracellular vesicles released by Müller glial cells provide neuroprotection to retinal ganglion cells?
Coorientador
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra, Portugal
2013/01 - 2020/11 Study on the contribution of the choroid to the pathophysiology of diabetic retinopathy
Orientador
 PhD (Doutoramento)
Universidade de Coimbra, Portugal
2015/06 - 2019/09 The changing brain in Alzheimer's disease: is the retina a mirror of disease onset and progression?
Orientador de Samuel Filipe Duarte Chiquita
 PhD in Basic and Applied Biology (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/09 - 2018/09 The role of a-adducin in the function and structure of retina
Coorientador de Beatriz Maria Gomes Oliveira
 Integrated Master in Biomedical Engineering (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/06 - 2017/09 Can the retina be a window to the changing brain in Alzheimer's disease?
Orientador de Rafael José Monteiro Carecho
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06 - 2017/09 Gender dimorphism of microglia morphology: adenosine and testosterone as putative modulators in transgender microglia
Coorientador de Carla Filipa Simões Henriques
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2016/06 - 2017/09 Vascular Effects of Glucagon-like peptide 1 Receptor Agonist (Liraglutide) on an Animal Model of Type 1 Diabetes
Coorientador de Carlota Sofia Ferreira de Nóbrega
 Master in Applied Pharmacology (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/06 - 2016/09 Glucocorticoids effects in the developing brain: a road to neuropsychiatric disorders
Coorientador de Helena Alexandra Ribeiro de Carvalho Pinheiro
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2011/09 - 2016/09 Can DPP-IV inhibitors or GLP-1 analogs be tomorrow´s therapy for diabetic retinopathy?
Coorientador de Andreia Fernandes Dâmaso Gonçalves
 PhD in Biomedical Engineering (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2012/02 - 2016/06 Controlling neuroinflammation in the retina through A2AR modulation: potential therapeutic implication in glaucoma
Coorientador de Maria Helena Bica Madeira
 PhD in Health Sciences, field of Biomedical Sciences, Inter-University Doctoral Programme in Ageing and Degeneration of Complex Biological Systems (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/09 - 2015/09 Microglia as cellular targets for immunomodulation during neurodevelopment
Coorientador de Sónia Raquel Nunes Henriques
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/09 - 2015/09 Microglia reactivity under elevated hydrostatic pressure conditions: is there a role for adenosine and adenosine A2A receptors
Coorientador de Ana Catarina Rodrigues Neves
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/09 - 2015/09 Role of RNA-binding proteins in microglia activation/deactivation
Coorientador de Ana Teresa Magalhães Azeredo Keating
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2014/09 - 2015/09 Evaluation of the potential anti-inflammatory and neuroprotective effect of a FAAH inhibitor in glaucoma models
Orientador de Joana Margarida Cardoso Serra Martins
 Master in Pharmaceutical Biotechnology (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2009/03 - 2015/05 Modulation of retinal ganglion cell function and implications for neuroprotection
Orientador de João Filipe da Costa Martins
 PhD in Health Sciences, speciality Biomedical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09 - 2014/09 Involvement of the NPY system in the inflammatory responses mediated by retinal microglial cells: modulation by sitagliptin
Orientador de Sandra Raquel Félix Guimarães Correia
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2013/09 - 2014/09 Role of adenosine A2A receptor in pressure-induced retinal microglia reactivity
Coorientador de Inês Sofia Dinis Aires
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2009/05 - 2013/12 Evaluation of the potential protective effects of adenosine A3 receptor in retinal ganglion cell degeneration
Orientador de Joana Margarida Fernandes Galvão
 PhD in Health Sciences, speciality Biomedical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2012/09 - 2013/09 Modulation of pro-inflammatory response of retina by adenosinergic system - neuroinflammation/neuroprotection
Coorientador de Raquel Sofia Freitas Boia
 Master in Biochemistry (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/09 - 2013/09 Modulation of pro-inflammatory responses in the retina by Neuropeptide Y - the role of NPY Y1 receptor
Orientador de Filipe Manuel Rijo Mendes Martins Elvas
 Master in Applied Pharmacology (Mestrado)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2008/10 - 2013/04 Neuropeptide Y in the retina : why and what for?
Coorientador de Ana dos Santos Carvalho
 PhD in Pharmacy, speciality in Pharmacology and Pharmacotherapy (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2008/01 - 2012/12 Impact of methamphetamine on blood-brain barrier function
Coorientador de Tânia Sofia Cordeiro Martins
 PhD in Health Sciences, speciality in Biomedical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2008/01 - 2012/11 Impact of diabetes on exocytosis/neurotransmitter release in the retina
Orientador de Filipa Isabel Cabaço Baptista
 PhD in Biosciences, speciality in Cellular and Molecular Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/09 - 2012/08 Reciprocal modulation of ATP and glutamate release in glia purified cultures from chick embryo retinas
Orientador de Erick Correia Loiola
 PhD in Neurosciences (Doutoramento)
Universidade Federal Fluminense, Brasil
2007/04 - 2012/06 Regulation of AMPA receptors by hyperglycemia in the retina
Orientador de Aurea Filipa de Aguiar Castilho
 PhD in Biology, speciality in Cellular Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2011/09 - 2012/04 Participation of GABA and cannabinoids in retinal ischemia: relevance for glaucoma
Orientador de Vivian Sayuri Miya Coreixas
 PhD in Neurosciences (Doutoramento)
Universidade Federal Fluminense, Brasil
2010/11 - 2012/01 Modulation of vitamin C transport to the central nervous system
Orientador de Camila Cabral Portugal
 PhD in Neuroimmunology (Doutoramento)
Universidade Federal Fluminense, Brasil
2010/11 - 2012/01 Regulation of neuronal and microglial function by Src tyrosine kynase
Orientador de Renato Esteves da Silva Socodato
 PhD in Neurosciences (Doutoramento)
Universidade Federal Fluminense, Brasil
2010/09 - 2011/12 Tauroursodeoxycholic acid: a novel neuroprotective drug in diabetic retinopathy?
Coorientador de Alexandra Menezes Martins
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2010/09 - 2011/11 Role of adenosine A2A receptor in controlling neuroinflammation mediated by retinal microglial cells
Coorientador de Maria Helena Bica Madeira
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2007/04 - 2011/03 Molecular and cellular changes triggered by diabetes in the hippocampus
Orientador de Joana Margarida Navalho Gaspar
 PhD in Biology, speciality in Cellular Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/09 - 2010/09 Exploring the impact of ecstasy on retinal physiology: A pioneer study
Orientador de Ana Maria Gonçalves Baptista
 Integrated Master in Biomedical Engineering (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2009/06 - 2010/09 Protective effect of calcium dobesilate against inflammation and oxidative/nitrosative stress in the retina of a diabetic rat model
Orientador de Paula Cristina Antunes Voabil
 Master in Advanced Specialization (2nd cycle) in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2005/02 - 2010/01 The role of inflammatory mediators in retinal microvascular dysfunction: implications for the blood-retinal barrier breakdown in diabetic retinopathy
Orientador de Célia Alexandra Ferreira de Oliveira Aveleira
 PhD in Biomedical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Medicina, Portugal
2006/10 - 2009/05 The effects of 3,4-methylenedioxymethamphetamine administration in rat electroretinogram
Coorientador
 Master in Cellular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007/10 - 2008/12 Effect of high glucose on AMPA receptors content in the retina e hippocampus
Orientador de Joana Manuela Torres Liberal
 Master in Cellular and Molecular Biology (Mestrado)
Universidade de Aveiro Departamento de Biologia, Portugal
2002/11 - 2008/12 Mechanisms of cellular dysfunction in diabetic retinopathy : involvement of nitric oxide
Orientador de Ermelindo Carreira Leal
 PhD in Biology, speciality in Cellular Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2002/11 - 2008/06 Mechanisms of neurodegeneration in the early stages of diabetic retinopathy: the involvement of glutamate
Orientador de Ana Raquel Sarabando Santiago
 PhD in Biology, speciality in Cellular Biology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2003/10 - 2008/05 Neuropeptide Y and their receptors in the retina: from proliferation to neuroprotection
Coorientador de Ana Rita Costa Álvaro
 PhD in Health Sciences and Technologies, speciality in Cellular and Molecular Biology (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2005/01 - 2008/03 Protective role of hemo-oxygenase-1 in diabetic retinopathy
Orientador de Áurea Filipa de Aguiar Castilho
 Master in Vision Sciences (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2005/10 - 2007/11 Evaluation of candidate genes in diabetic retinopathy
Coorientador de Ângela Sofia Oliveira Castela
 Master in Cellular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2021/11/30 - Atual Chair - Portuguese Glial Network Meeting (2021/11/30)
Congresso (Presidente da Comissão Organizadora)
 Rede Glial Portuguesa, Portugal
2022/07/09 - 2022/07/14 Organizing Committee - 25th IUBMB, 46th FEBS, 15th PABMB Congress - ¿he Biochemistry Global Summit, Lisbon, 9-14 July 2022 (2022/07/09 - 2022/07/14)
Congresso (Membro da Comissão Organizadora)
 Federation of European Biochemical Societies, Reino Unido
2019/07/10 - 2019/07/13 XIV European Meeting on Glial Cells in Health and Disease", Porto, Portugal (2019/07/10 - 2019/07/13)
Congresso (Membro da Comissão Organizadora)
2019 - 2019 IV Symposium of the Portuguese Glial Network - Glia Diversity in Neuromodulation and Neurodegeneration, Lisbon, Portugal (2019/05/29)
Simpósio (Membro da Comissão Organizadora)
2018 - 2018 III Symposium of the Portuguese Glial Network, Porto, Portugal (2018/05/18)
Simpósio (Membro da Comissão Organizadora)
2018 - 2018 Symposium: "Adenosine signaling in the retina" in "Purines 2018 International", Foz do Iguaçu, Brazil (2018/06/18 - 2018/06/22)
Simpósio (Coorganizador)
2017 - 2017 II Symposium of the Portuguese Glial Network, Braga, Portugal (2017/05/24)
Simpósio (Membro da Comissão Organizadora)
2016 - 2016 I Symposium of the Portuguese Glial Network, Braga, Portugal (2016/11/02)
Simpósio (Membro da Comissão Organizadora)
2015 - 2015 Symposium: "Portugal - Brazil: Inflammation and Redox Signaling" at "23rd Congress of the International Union for Biochemistry and Molecular Biology - 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology", Foz do Iguaçu, Brazil (2015/08/24 - 2015/08/28)
Simpósio (Coorganizador)
2015 - 2015 VII Annual Meeting of IBILI, Coimbra, Portugal (2015/12/03 - 2015/12/04)
Encontro (Membro da Comissão Organizadora)
2014 - 2014 VI Annual Meeting of IBILI, Coimbra, Portugal (2014/12/11 - 2014/12/12)
Encontro (Membro da Comissão Organizadora)
2014 - 2014 XVIII Congress of the Portuguese Biochemical Society, Coimbra, Portugal (2014/12/17 - 2014/12/20)
Congresso (Membro da Comissão Organizadora)
2013 - 2013 Workshop "Beating the Blood-Brain & Other Blood Barriers", Lisboa, Portugal (2013/02/06 - 2013/02/08)
Oficina (workshop) (Membro da Comissão Organizadora)
2013 - 2013 XII Meeting of the Portuguese Society for Neurosciences", Luso, Portugal (2013/05/30 - 2013/06/01)
Congresso (Membro da Comissão Organizadora)
2013 - 2013 Symposium: "Neurochemistry: Discovering New Mechanisms and Treatments for Nervous System Diseases" in "XII PABMB Congress”, Puerto Varas, Chile (2013/11/09 - 2013/11/14)
Simpósio (Coorganizador)
2013 - 2013 V Annual Meeting of IBILI, Coimbra, Portugal (2013/12/12 - 2013/12/13)
Encontro (Membro da Comissão Organizadora)
2012 - 2012 IV Annual Meeting of IBILI, Coimbra, Portugal (2012/12/06 - 2012/12/07)
Encontro (Membro da Comissão Organizadora)
2011 - 2011 III Annual Meeting of IBILI, Coimbra, Portugal (2011/12/06 - 2011/12/07)
Encontro (Membro da Comissão Organizadora)
2010/12/10 - 2010/12/11 II Annual Meeting of IBILI", Coimbra, Portugal (2010/12/10 - 2010/12/11)
Encontro (Membro da Comissão Organizadora)
2009/12/11 - 2009/12/13 I Annual Meeting of IBILI", Coimbra, Portugal (2009/12/11 - 2009/12/13)
Encontro (Membro da Comissão Organizadora)
2008/09/01 - 2008/09/04 Co-organisor of the Symposium: "Neurobiology of Retinal Diseases", at I Congress IBRO/LARC of Neurosciences for Latin America, Caribbean and Iberian Peninsula, Búzios, Brazil, September 1-4. (2008/09/01 - 2008/09/04)
Simpósio (Coorganizador)
2007/04/27 - 2007/04/28 2nd International Meeting of the Portuguese Society for Stem Cells and Cellular Therapy, Coimbra, Portugal (2007/04/27 - 2007/04/28)
Encontro (Coorganizador)
2005/01/07 - 2005/01/08 I Meeting of the Portuguese Society for Stem Cells and Cellular Therapy, Lisbon, Portugal (2005/01/07 - 2005/01/08)
2004 - 2004 Workshop on Ageing, Coimbra, Portugal (2004/10/01)
2001/09/13 - 2001/09/14 7th Meeting of the Portuguese Society for Neurosciences, Luso, Portugal (2001/09/13 - 2001/09/14)

Arbitragem científica em conferência

Nome da conferência Local da conferência
2023/05/02 - 2023/05/02 7th Symposium of the Portuguese Glial Network Universidade do Algarve
2022/10/18 - 2022/10/18 VI Symposium of the Portuguese Glial Network Instituto de Investigação e Inovação em Saúde
2022/07/09 - 2022/07/14 The Biochemistry Global Summit - 46th FEBS Congress, 25th IUBMB Congress and 15th PABMB Joint Congress - Member of the Local Organizing Committee Portuguese Biochemical Society
2021/11/30 - 2021/11/30 V Symposium of the Portuguese Glial Network - Glial Cells at the Crossroad of Health and Disease - Chair Portuguese Glial Network
2021/10/14 - 2021/10/16 XXI SPB Congresso Nacional de Bioquímica Sociedade Portuguesa de Bioquímica - Universidade de Évora
2021/10/14 - 2021/10/16 XXI SPB - National Congress of Biochemistry - Tuning Biochemistry with Life Sciences and Society", Évora, Portugal Portuguese Biochemical Society

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021/09 - Atual Antioxidants (Special issue Oxidative Stress in Neurodegeneration and Neuroinflammation) MDPI
2021/02 - Atual Frontiers in Neuroscience (Associate Editor) Frontiers
2020/01 - 2021/02 Frontiers in Neuroscience (Review Editor) Frontiers
2015 - 2018 Ophthalmic Research (1423-0259) S. Karger AG
2006 - 2011 Recent Patent Reviews on CNS Drug Discovery Bentham Science

Membro de associação

Nome da associação Tipo de participação
2019/01 - Atual Laboratório Colaborativo (CoLab) VectorB2B - Drug Developing - Associação para Investigação em Biotecnologia Member of the administrative council
2016/09 - Atual Portuguese Glial Network Founder and member of the Coordinating Committee
2008 - 2023/12 Portuguese Society of Diabetology (SPD)
2006 - 2023/12 International Society for Eye Research (ISER) Member in some years.
2004 - 2023/12 European Association for Vision and Eye Research (EVER) Member in some years.
1998 - 2023/12 Portuguese Society of Pharmacology (SPF) Member
1996 - 2023/12 Portuguese Biochemical Society (SPB) Secretary-General, vice-President and President between 2004-2013, and member.
1994 - 2023/12 Portuguese Society for Neurosciences (SPN) Member of the fiscal council (2020-2023), and member.
2001 - 2023 Association for Research in Vision and Ophthalmology (ARVO, EUA) Member in some years.
1998 - 2023 Society for Neuroscience (SfN, EUA) Member in some years
2005 - 2012 Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) Founder and Secretary between 2005-2007.

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019/04 - 2023/12 Member of the Committee for Ethical Issues of the Multidisciplinary Institute of Ageing (MIA) - Portugal (Teaming Grant)
Consultor
 Universidade de Coimbra, Portugal
2020/06 - 2023/05 Member of the fiscal council of the Portuguese Society for Neuroscience
Membro
 Sociedade Portuguesa de Neurociências, Portugal
2019 - 2019 IV Symposium of the Portuguese Glial Network - Glia Diversity in Neuromodulation and Neurodegeneration" Lisbon, Portugal
Membro
2019 - 2019 XVI Meeting of the Portuguese Society for Neuroscience, Lisbon, Portugal
Membro
2018 - 2018 III Symposium of the Portuguese Glial Network, Porto, Portugal
Membro
2017 - 2017 II Symposium of the Portuguese Glial Network, Braga, Portugal
Membro
2015 - 2015 XIV Meeting of the Portuguese Society for Neurosciences, Póvoa de Varzim, Portugal
2015 - 2015 XXXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular", Valencia, Spain
2015 - 2015 VII Annual Meeting of IBILI, Coimbra, Portugal
2014/09/04 - 2014/09/05 Participation in FEBS (Federation of European Biochemical Societies) Council on behalf of the Portuguese Biochemical Society, Paris, France
2014 - 2014 VI Annual Meeting of IBILI, Coimbra, Portugal
2013/11/11 - 2013/11/11 Participation in PABMB (Pan-American Association for Biochemistry and Molecular Biology) Council on behalf of the Portuguese Biochemical Society, Puerto Varas, Chile
2013/07/11 - 2013/07/12 Participation in FEBS (Federation of European Biochemical Societies) Council on behalf of the Portuguese Biochemical Society, Saint Petersburg, Russia
2013 - 2013 Beating the Blood-Brain & Other Blood Barriers Symposium, Lisbon, Portugal
Membro
2013 - 2013 XII PABMB Congress", Puerto Varas, Chile
2013 - 2013 V Annual Meeting of IBILI, Coimbra, Portugal
2012/09/09 - 2012/09/10 Participation in FEBS (Federation of European Biochemical Societies) Council on behalf of the Portuguese Biochemical Society, Seville, Spain
2012 - 2012 IV Annual Meeting of IBILI, Coimbra, Portugal
Membro
2011/06/30 - 2011/07/01 Participation in FEBS (Federation of European Biochemical Societies) Council on behalf of the Portuguese Biochemical Society, Turin, Italy
2011 - 2011 III Annual Meeting of IBILI", Coimbra, Portugal
Membro
2010 - 2010 II Annual Meeting of IBILI", Coimbra, Portugal
Membro
2009/12/11 - 2009/12/13 I Annual Meeting of IBILI", Coimbra, Portugal
Membro
2009/04/29 - 2009/04/30 4th International Meeting of the Portuguese Society for Stem Cells and Cellular Therapy", Lisboa, Portugal
Membro
2008/04/23 - 2008/04/24 3rd International Meeting of the Portuguese Society for Stem Cells and Cellular Therapy", Faro, Portugal
Membro
2007/04/27 - 2007/04/28 2nd International Meeting of the Portuguese Society for Stem Cells and Cellular Therapy", Coimbra, Portugal
Membro
2006/05/30 - 2006/05/31 1st Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies, Madeira, Portugal
Membro

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023/05 - 2023/05 Evaluation of a grant submitted to the French National Research Agency (ANR). Agence nationale de la recherche, França
2023/03 - 2023/03 Evaluation of a grant submitted to the German Research Foundation (DFG). Deutsche Forschungsgemeinschaft, Alemanha
2022/08 - 2022/08 Evaluation of an application to the Emmy Noether Programme. Deutsche Forschungsgemeinschaft, Alemanha
2021/12 - 2022/02 Grant Evaluator for German Research Foundation Deutsche Forschungsgemeinschaft, Alemanha
2021/07 - 2021/09 Grant evaluator - Swiss National Science Foundation Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung, Suiça
2021/07 - 2021/09 Grant Evaluator - Alzheimer Nederland Alzheimer Nederland, Países Baixos
2021 - 2021 Member of the jury - Grants submitted to CICS-UBI (Covilhã) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021 - 2021 Grant evaluator for The Wellcome Trust/DBT India Alliance Fellowship The Welcome Trust, Reino Unido
2018 - 2018 Grant reviewer - Fight for Sight (British Eye Research Foundation).
2012 - 2012 Grant reviewer - National Science Centre (Narodowe Centrum Nauki), Poland.
2008 - 2008 Grant reviewer - Non-Clinical Research Fellowship of the Diabetes Research & Wellness Foundation.
2008 - 2008 Grant reviewer - Institute of Interdisciplinary Research, University of Coimbra.
2007 - 2007 Grant reviewer - Fight for Sight (British Eye Research Foundation).
2007 - 2007 Reviewer of the PhD fellowships supported by the Institute of Interdisciplinary Research, University of Coimbra.
Distinções

Prémio

2023 Bolsa Emílio Peres / SPD
Sociedade Portuguesa de Diabetologia, Portugal
2023 Honorable Mention Pedro Eurico Lisboa / SPD
Sociedade Portuguesa de Diabetologia, Portugal
2023 Best Oral Communication - Fundamental Research
Sociedade Portuguesa de Diabetologia, Portugal
2023 Best Oral Communication
2022 Best Poster
2022 Best Research Project
2022 Best Translational Research Project
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2021 Best Oral communication - The Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS)
Controlled Release Society, Portugal
2021 Best Poster of Clinical Research (co-author) - 17º Congresso Português de Diabetes
2021 Best Oral Communication
Sociedade Portuguesa de Bioquímica, Portugal
2019 Young Investigator Competition Award - MEDICON 2019 - 15th Mediterranean Conference on Medical and Biological Engineering and Computing
2018 Best poster presented at "European Association for Vision and Eye Research - EVER 2018" (section Neurophthalmology), Nice, France
European Association for Vision and Eye Research, Bélgica
2018 Best short talk presented at "IV Reunião Nacional de Bioquímicos", Lisbon, Portugal
2018 Best short talk presented at "IV Reunião Nacional de Bioquímicos", Lisbon, Portugal
2018 Best poster presented at "XI Encontro Nacional de Estudantes de Bioquímica", Porto, Portugal
2017 Orlando Leitão award to the work presented at “Congresso de Neurologia” 2016, Lisbon, Portugal
2015 Best poster award in basic research presented at "Reunião Anual da Sociedade Portuguesa de Diabetologia", Tomar, Portugal
2015 Best oral communication (Bayer award) presented at "Reunião de Primavera-Verão do Grupo de Estudos de Esclerose Múltipla (GEEM)", Guimarães, Portugal
Bayer Fund, Estados Unidos
2015 Best poster presented at "VII Annual Meeting of IBILI", Coimbra, Portugal
2015 Best oral communication in neurosciences and autoimunity presented at "Unit for Multidisciplinary Research in Biomedicine (UMIB) Summit 2015", Porto, Portugal
2015 Best rapid fire presentation presented at "VII Annual Meeting of IBILI" (section "Vision Research"), Coimbra, Portugal
2015 Best rapid fire presentation presented at "VII Annual Meeting of IBILI" (section "Brain Sciences"), Coimbra, Portugal
2015 Best rapid fire presentation presented at "VII Annual Meeting of IBILI" (section "New Techniques in Bioimaging"), Coimbra, Portugal
2015 Mantero Belard Prize - Santa Casa Awards - Neurosciences
Santa Casa da Misericórdia de Lisboa, Portugal
2014 Best poster presented at "XVIII Congress of the Portuguese Biochemical Society", Coimbra, Portugal
Sociedade Portuguesa de Bioquímica, Portugal
2014 Best poster presented at the "VI Annual Meeting of IBILI", Coimbra, Portugal
2014 Best Scientific Image Award attributed by the “Gabinete de Apoio à Investigação (GAI)”, Faculty of Medicine, University of Coimbra
2014 Best Scientific Image Award (2nd place) attributed in contest "Best Photo in Vision Research and Ophthalmology", promoted by European Vision Institute EVI in colboration with Heidelberg Engineering GmbH
2013 Runner up prize from annual poster session of Institute of Ophthalmology, UCL, London
2013 Best oral communication presented at "4th PF2MUC Symposium", Coimbra, Portugal
2013 Best scientific image award attributed by the “Gabinete de Apoio à Investigação (GAI)", Coimbra, Portugal
2012 Best Poster presented at the "IV Annual Meeting of IBILI", Coimbra, Portugal
2012 Runner up prize from annual poster session of Institute of Ophthalmology, UCL, London
2011 Best oral communication presented at Mediterranean Group for the Study of Diabetes, Casablanca, Morocco
2011 Best poster presented at 1st PF2MUC symposium, Coimbra, Portugal
2007 Best poster presented at EVER 2007 Meeting (section of Physiology, Biochemistry and Pharmacology), Portoroz, gy, Biochemistry and Pharmacology), Portoroz, Slovenia
European Association for Vision and Eye Research, Bélgica
2005 Best poster presented at 15th Meeting of the European Association for the Study of Diabetes - Eye Complications Study Group (EASDec), Coimbra, Portugal
2005 Best poster presented at EVER 2005 Meeting (section of Retina and Vitreous) , Vilamoura, Portugal
European Association for Vision and Eye Research, Bélgica
2004 Best poster presented at EVER 2004 Meeting (section of Retina, Cornea, Anatomy/Cell Biology, Uveitis and Lens) , Vilamoura, Portugal
European Association for Vision and Eye Research, Bélgica
2001 Grant for participation on the "Joint Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry", Buenos Aires, Argentina
2001 Grant for participation on the Advanced Course "Free Radicals, Nitric Oxide, and Inflammation: Molecular, Biochemical, and Clinical Aspects". Society for Free Radical Research, FEBS e NATO, Antalya, Turkey
2000 Grant for participation on the "First Conference on Mechanisms of Cell Death and Disease: Advances in Therapeutic Intervention", Dublin, Ireland
1999 Grant for participation on the Advanced Course "Electron Microscopy and Stereology in Molecular Cell Biology". FEBS, Oslo, Norway
1999 Grant for participation on the Advanced Course "Joint Meeting of the International Society for Neurochemistry and the European Society for Neurochemistry", Berlin, Germany
1999 Grant for participation on the Advanced Course "FENS Winter School: Nervous System Reaction to Neuronal Loss and Injury". FENS, Kitzbühel, Austria
1998 Grant for participation on the Advanced Course "Second Practical Workshop on Apoptosis". European School of Haematology, Lecce, Italy
1998 Grant for participation on the Advanced Course "Molecular Mechanisms of Transcellular Signaling: from Membrane Receptors to Transcription Factors". FEBS e NATO, Spetses, Greece,
1997 Grant for participation on the Advanced Course "First Practical Training Course on Apoptosis"; European School of Haematology, Saclay, France