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Currently, A.S. Gomes is an Assitant Researcher at CIIMAR, in Bioinspired Ocean interfaces (BiO) group, under the PRR funded academia-industry consortia INOVAMAR (WP2 Vertical Bivalves; C644915664-00000026). Her main research interests are focused on sustainable antifouling strategies, particularly the disclosure of molecular targets and antifouling mechanisms of action. She was a post-doc researcher at CIIMAR in an environment-related FCT-funded project (PTDC/CTA-AMB/0853/2021), by seeking new eco-friendly small molecules with nontoxic antifouling activity to prevent biofouling by marine organisms in submerged artificial infrastructures. A.S. Gomes completed her PhD in Molecular and Cellular Biotechnology applied to Health Sciences, U.Porto (2019) and MSc in Pharmaceutical Sciences, U.Porto (2011). She has a strong background in a multitude of scientific areas and methodologies nurturing an interdisciplinary way of working and eager for continuous learning, integrating different perspectives to solve a problem. She worked in medicinal chemistry, biotechnology, nanotechnology, biophysics, particularly in drug discovery and mechanism of action elucidation. She developed technical skills on chemical synthesis, spectroscopic analytical methods (HPLC-DAD, MS, NMR, FTIR), bioactivity assays, recombinant protein production, in vitro cellular assays, microscopy, flow cytometry, molecular targets expression (WB, IHC), binding assays and structural biology (crystallization, DSF,DLS, DSC, ITC, MST, CETSA, STD-NMR). A.S.Gomes during her PhD worked in renowned national and international labs, namely at (i) Molecular Biotechnology Laboratory (CEB, U.Minho, 1 year), (ii) Macromolecular Crystallography Laboratory (UCIBIO, FCT-U.NovaLisboa, 6 months), (iii) Laboratory of Molecular Biophysics (IRB Barcelona, Spain, 1 week), and (iv) Santos' Lab (U.Helsinki, Finland, 6 months), contributing to her ability to learn fast, work in international environment and adapt in different teams' dynamics and lab workflows. A.S. Gomes was PI in one CIIMAR SEED project (2023-2024), achieving scientific autonomy. She was a team member of two finished FCT funded projects (PTDC/DTP-FTO/1981/2014 and PTDC/MAR-BIO/4694/2014), and one proof-of-concept BIP.U.Porto project OceanCare. A.S.Gomes is author or co-author of 14 international peer-reviewed publications, of which 6 as first author, has an h-index of 12, with >360 citations by >320 documents. The publications span several research fields oncobiology, microbiology, pharmacology, toxicology, biochemistry, structural biology, drug discovery, nanotechnology and antifouling. Four of the publications are key reviews on drug pharmacokinetics, target protein structure, cellular metabolism and antifouling research. She has participated in national and international conferences/meetings with 14 talks and 18 poster communications. Scientific and lab experience has allowed A.S.Gomes to develop her resilience, decision ability, project management, writing, editing and science communication skills. A.S.Gomes has team coordinating and project management duties, has fostered national and international collaborations, and is supervising 2 MSc and 2 BSc students, and also has experience in teaching, both lectures and laboratory classes, allowing her to developed leadership and pedagogical skills. Recently, she concluded a postgrad course in Scientific Illustration motivated by her passion for Arts and Science.
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Identificação

Identificação pessoal

Nome completo
Ana Sara Gomes

Nomes de citação

  • Gomes, Ana Sara

Identificadores de autor

Ciência ID
5211-AD9F-0A1A
ORCID iD
0000-0002-9378-6043

Endereços de correio eletrónico

  • anasarag4@gmail.com (Profissional)
  • sara.gomes@ciimar.up.pt (Profissional)

Telefones

Telemóvel
  • 969487442 (Pessoal)

Domínios de atuação

  • Ciências Naturais - Ciências da Terra e do Ambiente - Ciências do Ambiente
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1)
Formação
Grau Classificação
2022/09 - 2023/06
Concluído
 Scientific illustration - Illustration in Natural Sciences (Ilustração Científica - Ilustração em Ciências Naturais) (Especialização pós-licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
 18 points (max 20)
2015/01/02 - 2019/09/17
Concluído
 International Doctoral Program in Molecular and Cellular Biotechnology applied to Health Sciences (Programa doutoral em Biotecnologia Molecular e Celular aplicada às Ciências da Saúde) (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"New anticancer drug candidates by targeting p53/p73: structural studies and nanodelivery systems" (TESE/DISSERTAÇÃO)
 Aprovado
2006/09 - 2011/10
Concluído
 Integrated Master in Pharmaceutical Sciences (Mestrado Integrado em Ciências Farmacêuticas) (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 16 points (max 20)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/08/15 - Atual Investigador Contratado (Investigação) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2022/10/15 - 2023/08/15 Pós-doutorado (Investigação) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/09/01 - 2022/08/31 Assistente Convidado (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
2019/09/01 - 2020/08/31 Assistente Convidado (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal
2019/10/01 - 2020/07/31 Professor Adjunto (Docente Ensino Superior Politécnico) Escola Superior de Enfermagem da Cruz Vermelha Portuguesa de Oliveira de Azeméis, Portugal
2012/09/21 - 2016/02/12 Assistente Convidado (Docente Universitário) Universidade do Porto Faculdade de Farmácia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/10/01 - 2022/08/31 Assistant Editor Areal Editores SA, Portugal
2013/07/29 - 2013/09/06 Volunteer in the Global Community Development Programmme of AIESEC AIESEC and ASSCODECHA (Associação Comunitária para o Desenvolvimento do Chamanculo - Maputo, Mozambique), Moçambique
2011/12/05 - 2012/09/05 Professional training in Regulatory Affairs of Medical Devices and Quality System Management Healthcare Sector, Siemens S.A., Portugal
2011/03/01 - 2011/05/27 Mobility Program (curricular training) - Programa de Aprendizagem ao longo da vida Organisation mondiale de la Santé, Suiça
2010/08/02 - 2010/08/31 Extracurricular training in Community Pharmacy - Student Exchange Program (in Budapest) International Pharmaceutical Students Federation (IPSF), Hungria
2009/08/31 - 2009/09/11 Extracurricular training in Quality Control Laboratory Instituto da Água da Região Norte (IAREN), Portugal
2008/09/01 - 2008/09/12 Extracurricular Training in Hospital Pharmacy Centro Hospitalar de Trás-os-montes e Alto Douro EPE, Portugal
Projetos

Bolsa

Designação Financiadores
2022/10/15 - 2023/08/14 Post-doc research grant in "Sustainable antifouling agents: from grape wastes to the sea with the green chemistry leading the way" (NIAF) project
2022_073_BPD_CTA-AMB
Bolseiro de Pós-Doutoramento
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
2016/02/01 - 2019/01/31 PhD studies in Molecular and Cellular Biotechnology applied to Health Sciences
PD/BD/114046/2015
Bolseiro de Doutoramento
Fundação para a Ciência e a Tecnologia
2015/02/01 - 2016/01/31 PhD studies in Molecular and Cellular Biotechnology applied to Health Sciences
PD/BI/105912/2014
Bolseiro de Investigação
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2023/08/15 - Atual Pacto da Bioeconomia Azul consortia project: INOVAMAR , Vertical Bivalves (WP2)
C644915664-00000026
Investigador
Governo da República Portuguesa

European Union
Em curso
2023/06/01 - 2024/07/31 SEED project: Mechanism of action elucidation of CIIMAR nature-inspired antifoulants
SEED project: Antifoulants
Investigador responsável
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental
Em curso
2022/10/15 - 2023/08/14 NIAF - Sustainable antifouling agents: from grape wastes to the sea with the green chemistry leading the way
PTDC/CTA-AMB/0853/2021
Bolseiro de Pós-Doutoramento
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2023/01/01 - 2023/06/30 OceanCare - Business Ignition Program (BIP) Proof
GRANT_NUMBER: OceanCare
Investigador
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Universidade do Porto
Em curso
2016/06/01 - 2019/05/31 Chemotherapic agents: Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents
PTDC/MAR-BIO/4694/2014:
Investigador
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/04/01 - 2019 ACTONP53: Targeting p53 family proteins: on the route to new anticancer agents
PTDC/DTP-FTO/1981/2014
Investigador
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009 - 2010 Two small molecules as potent inhibitors of human tumor cell lines: Synthesis, evaluation of physicochemical and biological properties and incorporation in nanosystems
Multidisciplinary Project
Investigador
Universidade do Porto Faculdade de Farmácia, Portugal
 Universidade do Porto
Concluído
Produções

Publicações

Artigo em conferência
  1. Gomes, Ana Sara; Vieira, David; Sousa, Emília; Afonso, Carlos; Pinto, Madalena; Carvalho, Félix; Santos-Silva, Alice. "TXA1, small molecule potent inhibitor of human tumor cell growth: synthesis and toxicological characterization". Trabalho apresentado em 2nd National Meeting on Medicinal Chemistry, coimbra, 2010.
    Publicado
Artigo em revista
  1. Neves, A.R.; Godinho, S.; Gonçalves, C.; Gomes, A.S.; Almeida, J.R.; Pinto, M.; Sousa, E.; Correia-da-Silva, M.. "A Chemical Toolbox to Unveil Synthetic Nature-Inspired Antifouling (NIAF) Compounds". Marine Drugs 22 9 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85205151609&partnerID=MN8TOARS.
    10.3390/md22090416
  2. Ana Sara Gomes. "Folic acid-mesoporous silicon nanoparticles enhance the anticancer activity of the p73-activating small molecule LEM2". International Journal of Pharmaceutics 624 (2022): 121959-121959. http://dx.doi.org/10.1016/j.ijpharm.2022.121959.
    10.1016/j.ijpharm.2022.121959
  3. Ana Sara Gomes; Helena Ramos; Alberto Inga; E Sousa; Lucília Saraiva. "Structural and Drug Targeting Insights on Mutant p53". Cancers (2021): https://www.mdpi.com/2072-6694/13/13/3344.
    10.3390/cancers13133344
  4. Gomes, A.S.; Ramos, H.; Gomes, S.; Loureiro, J.B.; Soares, J.; Barcherini, V.; Monti, P.; et al. "SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations". Biochimica et Biophysica Acta - General Subjects 1864 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073833530&partnerID=MN8TOARS.
    10.1016/j.bbagen.2019.129440
  5. Lemos, A.; Gomes, A.S.; Loureiro, J.B.; Brandão, P.; Palmeira, A.; Pinto, M.M.M.; Saraiva, L.; Sousa, M.E.. "Synthesis, biological evaluation, and in silico studies of novel aminated xanthones as potential p53-activating agents". Molecules 24 10 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85066292656&partnerID=MN8TOARS.
    10.3390/molecules24101975
  6. Raquel T. Lima; Diana Sousa; Ana Sara Gomes; Nuno Mendes; Rune Matthiesen; Madalena Pedro; Franklim Marques; et al. "The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization". Molecules (2018): http://www.mdpi.com/1420-3049/23/12/3301.
    10.3390/molecules23123301
  7. Gomes, Ana Sara; Trovão, Filipa; Pinheiro, Benedita; Freire, Filipe; Gomes, Sara; Oliveira, Carla; Domingues, Lucília; et al. "The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding". International Journal of Molecular Sciences (2018): http://www.mdpi.com/1422-0067/19/4/1184.
    10.3390/ijms19041184
  8. Gomes, A.S.; Ramos, H.; Soares, J.; Saraiva, L.. "p53 and glucose metabolism: an orchestra to be directed in cancer therapy". Pharmacological Research 131 (2018): 75-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044611009&partnerID=MN8TOARS.
    10.1016/j.phrs.2018.03.015
  9. Reis-Mendes, A.; Gomes, A.S.; Carvalho, R.A.; Carvalho, F.; Remião, F.; Pinto, M.; Bastos, M.L.; Sousa, E.; Costa, V.M.. "Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy". Archives of Toxicology 91 4 (2017): 1871-1890. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987667526&partnerID=MN8TOARS.
    10.1007/s00204-016-1839-z
  10. Soares, J.; Espadinha, M.; Raimundo, L.; Ramos, H.; Gomes, A.S.; Gomes, S.; Loureiro, J.B.; et al. "DIMP53-1: A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties". Molecular Oncology 11 6 (2017): 612-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-85025616812&partnerID=MN8TOARS.
    10.1002/1878-0261.12051
  11. Gomes, A.S.; Brandão, P.; Fernandes, C.S.G.; Da Silva, M.R.P.C.; De Sousa, M.E.D.S.P.; De Magalhães Pinto, M.M.. "Drug-like properties and ADME of xanthone derivatives: The antechamber of clinical trials". Current Medicinal Chemistry 23 32 (2016): 3654-3686. http://www.scopus.com/inward/record.url?eid=2-s2.0-84995948323&partnerID=MN8TOARS.
    10.2174/0929867323666160425113058
  12. Barbosa, J.; Lima, R.T.; Sousa, D.; Gomes, A.S.; Palmeira, A.; Seca, H.; Choosang, K.; et al. "Screening a small library of xanthones for antitumor activity and identification of a hit compound which induces apoptosis". Molecules 21 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85000443221&partnerID=MN8TOARS.
    10.3390/molecules21010081
  13. Bessa, L.J.; Palmeira, A.; Gomes, A.S.; Vasconcelos, V.; Sousa, E.; Pinto, M.; Da Costa, P.M.. "Synergistic effects between thioxanthones and oxacillin against methicillin-resistant staphylococcus aureus". Microbial Drug Resistance 21 4 (2015): 404-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937772878&partnerID=MN8TOARS.
    10.1089/mdr.2014.0162
  14. Silva, R.; Palmeira, A.; Carmo, H.; Barbosa, D.J.; Gameiro, M.; Gomes, A.; Paiva, A.M.; et al. "P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity". Archives of Toxicology 89 10 (2015): 1783-1800. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942198190&partnerID=MN8TOARS.
    10.1007/s00204-014-1333-4
Poster em conferência
  1. Gomes, Ana Sara; Resende, Diana I. S. P.; Pereira, Daniela; Cidade, Honorina; Sousa, Emília; Correia-da-Silva, Marta. "STD-NMR in antifouling agents: probing agent-target interactions.". Trabalho apresentado em EMBO Workshop: Chemical Biology, EMBL Advanced Training Centre, Heidelberg, Germany, P81, p. 105., 2024.
  2. Gomes, Ana Sara; Nunes, Cláudia; Pereira, Sandra; Cravo, Sara; Almeida, J.R.; Correia-da-Silva, Marta. "Structure-membrane interaction relationship to unveil the non-toxic antifouling mechanism of action of synthetic compounds.". Trabalho apresentado em 11th EFMC Young Medicinal Chemists’ Symposium (EFMC-YMCS), Rome, Italy, P046, p. 96., 2024.
  3. Correia-da-Silva, Marta; Gomes, Ana Sara; Almeida, J.R.. "Responsible production (SDG12) of safer-by-design antifouling additive for marine coatings to conserve and to sustainably use the oceans.". Trabalho apresentado em 6th International Conference on Green Chemistry and Sustainable and Sustainable Engineering (GreenChem-24), Lisboa, Portugal. P57, p. 154., 2024.
  4. Novais, Mariana; Margarido, Hélder; Gomes, Ana Sara; Sousa, Emília; Cidade, Honorina ; Pinto, Madalena; Fernandes, Carla. "Synthesis, acetylcholinesterase inhibition and antioxidant activity of a series of xanthones.". Trabalho apresentado em IJUP24 – 17th Young Research Meeting, University of Porto, Porto, Portugal., 2024.
  5. Gomes, Ana Sara; Godinho, Sara; Almeida, Joana; Correia-da-Silva, Marta. "Environmental benign antifouling agent, developed employing the tactics of medicinal chemistry, moved to “clinical” trials.". Trabalho apresentado em 15th National Organic Chemistry Meeting & 8th National Medicinal Chemistry Meeting, Faro, Portugal., 2024.
  6. Godinho, S.; Gomes, Ana Sara; Cravo, S.; Sousa, E.; Pinto, M.; Almeida, J.; Correia-da-Silva, M.. "Scale-up synthesis and in situ tests of an international protected antifouling agent.". Trabalho apresentado em Blue Think Conference 2023: Share Science, Spread Knowledge, CIIMAR – Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Matosinhos, Portugal., 2023.
  7. Matos, I.; Barros, J.; Gomes, Ana Sara; Santos, M.J.. "The importance of scientific illustration in entomological studies in the age of photography and artificial intelligence". Trabalho apresentado em XX Congreso Ibérico de Entomología: “Paremos el declive de los insectos”, Universidad de Alicante, Alicante, Spain, 2023.
  8. Novais, Mariana; Ribeiro, Catarina; Pinto, Abílio; Margarido, Hélder; Gomes, Ana Sara; Fernandes, Carla. "Xanthones: a possible therapeutic for Alzheirmer's disease?". Trabalho apresentado em XVI National Congress of Scientist on Action, Extremoz, Portugal, 2023.
  9. Gomes, Sara; Soares, Joana; Raimundo, Liliana; Pereira, Nuno; Monteiro, A.; Bessa, Claúdia; Gomes, Ana Sara; et al. "Reactivation of mutant p53R280K by SLMP53-1, a potential anticancer drug candidate". Trabalho apresentado em 7th International Mutant p53 Workshop, Melbourne, Australia, 2016.
  10. Soares, Joana; Raimundo, Liliana; Pereira, Nuno; Gomes, Sara; Bessa, Claúdia; Gomes, Ana Sara; Gomes, C.; et al. "Identification of a new reactivator of mutant p53 with in vivo antitumor activity". Trabalho apresentado em nternational Conference on Cancer Research and Targeted Therapy, Baltimore, USA, 2016.
  11. Reis-Mendes, Ana; Gomes, Ana Sara; Carvalho, R.A.; Remião, Fernando; Carvalho, Félix; Pinto, Madalena; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera. "Unveiling the cardiotoxicity of anticancer drugs: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Trabalho apresentado em 51st Congress of the European Societies of Toxicology (Eurotox 2015), Athens, Greece, 2015.
  12. Gomes, Ana Sara; Soares, Joana; Raimundo, Liliana; Monteiro, A.; Ramos, Helena; Santos, Maria; Saraiva, Lucília. "Targeting p53:MDM2/MDMX interaction by tryptophanol-derived oxazolopiperidone lactams". Trabalho apresentado em Integrative Structural Biology tools for the study of protein-ligand interactions (ISBIO 2015), Lisbon, Portugal, 2015.
  13. Reis-Mendes, Ana; Gomes, Ana Sara; Carvalho, R.A.; Remião, Fernando; Carvalho, Félix; Pinto, Madalena; Bastos, Maria de Lourdes; Sousa, Emília; Costa, Vera. "The cardiotoxicity of mitoxantrone: A comparative in vitro study between mitoxantrone and its naphthoquinoxaline metabolite". Trabalho apresentado em IJUP’15 – 8th Meeting of Your Researchers of the University of Porto, Porto, Portugal, 2015.
  14. Gomes, Ana Sara; Cravo, Sara; Sousa, Emília; Pinto, Madalena. "Microwave-assisted CuI catalysis to improve the synthesis of aminated thioxanthones". Trabalho apresentado em 10th National Meeting of Organic Chemistry/1st Luso-brazilian Symposium of Organic Chemistry, Lisbon, Portugal, 2013.
  15. Gomes, Ana Sara; Oliveira, Tiago; Sousa, D.; Lima, Raquel; Salvador, J. A. R.; Vasconcelos, Helena; Pinto, Madalena; Sousa, Emília. "Studies of the possible oxidative metabolism of a promising antitumor compound". Trabalho apresentado em XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting "Translational Research in Cancer – Bringing Basic Science and Pathology to Clinical Oncology", Porto, Portugal, 2013.
  16. Gomes, Ana Sara; Vieira, David; Sousa, Emília; Afonso, Carlos; Pinto, Madalena; Carvalho, Félix; Santos-Silva, Alice. "TXA1, small molecule potent inhibitor of human tumor cell growth: synthesis and toxicological characterization". Trabalho apresentado em 2nd National Meeting on Medicinal Chemistry, Porto, Portugal, 2010.
  17. Vieira, David; Gomes, Ana Sara; Sousa, Emília; Afonso, Carlos; Pinto, Madalena; Carvalho, Félix; Santos-Silva, Alice. "Potential mutagenicity of TXA1, a small molecule potent inhibitor of tumor cell growth". Trabalho apresentado em Young European Scientist Meeting Guide: YES Meeting, Porto, Portugal, 2010.
  18. Gomes, Ana Sara; Vieira, David; Palmeira, Andreia; Afonso, Carlos; Sousa, Emília; Pinto, Madalena. "Synthesis of xanthone derivatives with promising antifungal activity". Trabalho apresentado em IJUP10 – 3rd Meeting of Young Researchers, University of Porto, Porto, Portugal, 2010.
Tese / Dissertação
  1. "New anticancer drug candidates by targeting p53/p73: structural studies and nanodelivery systems". Doutoramento, Universidade do Porto, 2019. https://sigarra.up.pt/icbas/pt/pub_geral.pub_view?pi_pub_base_id=355286.

Artística / Interpretação

Exposição artística
  1. Ciclo de vida do escaravelho-do-alecrim (Chrysolina americana); Diferenças morfológicas entre os cogumelos frade (Macrolepiota procera) e o falso-frade (Chlorophyllum rhacodes). ILUSTRA UP II - a ilustração científica na Universidade do Porto. 2023.
  2. Matar o pai. Catarse exhibition.. 2020.
  3. Without title, 2020; XXXVI Collective exhibition of the members of Árvore Cooperative. 2020.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/09/09 STD-NMR in antifouling agents: probing agent-target interactions. EMBO Workshop: Chemical Biology
EMBL Advanced Training Centre (Heidelberg, Alemanha)
2024/09/09 Mechanism of action elucidation of CIIMAR nature-inspired antifoulants. CIIMAR's Anual Meeting
CIIMAR (Interdisciplinary Centre of Marine and Environmental Research) (Matosinhos, Portugal)
2024/07/08 “Pitch”: uma prática pedagógica 5C - Concisa, Clara, Cativante, Conceitual e Criativa 10º Congresso Nacional de Práticas Pedagógicas no Ensino Superior (CNaPPES.24)
Instituto Superior de Contabilidade e Administração do Porto (ISCAP, P.PORTO) (Matosinhos, Portugal)
2024/06/16 Moving towards eco-friendly long-lasting anti-fouling solutions 20th International Congress on Marine Corrosion and Fouling (ICMCF)
South China University of Technology (Guangzhou, China)
2024/04/15 WP2: Effectiveness of green antifouling agents in biofouling prevention. ATLANTICLAM – Final Public Session
Oceano Fresco, Mercedes-EQ Lounge (Nazaré, Portugal)
2017/02/02 Uncovering the binding of the anticancer small molecule SLMP53-1 to mutant p53R280K SPF 2017 – XLVII Annual Meeting of the Portuguese Society of Pharmacology, XXXV Meeting of Clinical Pharmacology, XVI Meeting of Toxicology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2017/02/02 Mitoxantrone and its naphthoquinoxaline metabolite: A comparative study in differentiated H9c2 cells SPF 2017 - XLVII Annual Meeting of the Portuguese Society of Pharmacology, XXXV Meeting of Clinical Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal)
2016/02/17 Targeting p53-MDM2 interaction with LEM2-aminated derivatives for cancer therapy IJUP 2016 – 9th Meeting of Your Researchers of the University of Porto
University of Porto (Porto, Portugal)
2016/02/04 DIMp53-1: a novel dual inhibitor of p53-mdms interactions with potent in vivo antitumor activity XLVI Annual Meeting of the Portuguese Society of Pharmacology, XXXIV Meeting of Clinical Pharmacology, XV Meeting of Toxicology
Portuguese Society of Pharmacology (Porto, Portugal)
2015/12/01 Antitumor activity of TXA1, an autophagy inducer which affects cholesterol localization 11th National Meeting of Organic Chemistry/4th Meeting of Medicinal Chemistry
(Porto, Portugal)
2015/11/19 Xantonas como fonte de inspiração para a obtenção de novos inibidores da interação p53/p73:MDM2 I Scientific Meeting of Chemistry Students Union of the Academic Association of Coimbra
Students Union of the Academic Association of Coimbra (Coimbra, Portugal)
2013/02/21 A new small molecule with antitumour and chemosensitizing potential as P-gp inhibitor COST Action CM1106 “Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells”
IPATIMUP (Porto, Portugal)
2011/02/17 Synthesis and genotoxicity evaluation of a thioxanthone derivative IJUP11 – 4th Meeting of Your Researchers of the University of Porto
University of Porto (Porto, Portugal)
2010/04/21 New synthetic approaches using microwave radiation 2nd Portuguese Young Chemists Meeting
Portuguese Society of Chemistry (Aveiro, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/12/13 - Atual Cyanobacteria extracts library: source for antifouling compounds screening
Coorientador de Hanne Peeters
Odisee, University of Applied Sciences, Bélgica
2024/11/18 - Atual Development of biogenic hydrogels with embedded cyanobacteria for marine antifouling applications
Coorientador de Margarita Brante
 EU-CONEXUS Joint Master Programme in Marine Biotechnology (Mestrado)
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2024/11/18 - Atual Optimization of cyanobacteria growth for the production of bioactive compounds
Coorientador de Hugo Sá
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2024/03/01 - Atual Small-molecules modulators of TRP channels
Coorientador de Bruno da Silva Martins Loureiro
 Mestrado em Química Farmacêutica (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2024/11/04 - Atual Blue Biotechnology, Ecotoxicology and Health (BBEH) group meetings (2024/11/25)
Outro (Membro da Comissão Organizadora)
 Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2023/02/17 - 2023/03/16 Nature-inspired antifoulants (NIAF) circular talks: cycle of meetings about the results of the FCT project PTDC/CTA-AMB/0853/2021. (2023/02/17 - 2023/03/16)
Outro (Coorganizador)
 Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2021/12/09 - 2021/12/09 Jornadas Pedagógico-Científicas Madalena Pinto ‘21. Pharmaceutical Sciences' students choose a topic of Medicinal Chemistry, design a poster communication that is presented on a meeting open to the general public. (2021/12/09 - 2021/12/09)
Encontro (Coorganizador)
 Universidade do Porto Faculdade de Farmácia, Portugal
2019/11/21 - 2019/11/21 Jornadas Pedagógico-Científicas Madalena Pinto '19. Pharmaceutical Sciences' students choose a topic of Medicinal Chemistry, design a poster communication that is presented on a meeting open to the general public. (2019/11/21 - 2019/11/21)
Encontro (Coorganizador)
 Universidade do Porto Faculdade de Farmácia, Portugal
2016/06/21 - 2016/06/22 3rd Annual Scientific BiotechHealth Symposium: “Emerging Technologies in health sciences” (2016/06/21 - 2016/06/22)
Simpósio (Membro da Comissão Organizadora)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/06/09 - 2016/06/09 Demo presentation: Biomolecule Analytics Using Microscale Thermophoresis (MST) by Dr. Aileen Justies from Nanotemper Technologies (2016/06/09)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Farmácia, Portugal
2015/12/10 - 2015/12/11 IX Jornadas monográficas de Química Farmacêutica. Pharmaceutical Sciences' students choose a topic of Medicinal Chemistry, design a poster communication that is presented on a meeting open to the general public. (2015/12/10 - 2015/12/11)
Encontro (Coorganizador)
 Universidade do Porto Faculdade de Farmácia, Portugal
2014/12/04 - 2014/12/05 VIII Jornadas monográficas de Química Farmacêutica. Pharmaceutical Sciences' students choose a topic of Medicinal Chemistry, design a poster communication that is presented on a meeting open to the general public. (2014/12/04 - 2014/12/05)
Encontro (Coorganizador)
 Universidade do Porto Faculdade de Farmácia, Portugal
2014/07/31 - 2014/08/09 60th International Pharmaceutical Students Federation World Congress (2014/07/31 - 2014/08/09)
Congresso (Membro da Comissão Científica)
 Universidade do Porto Faculdade de Farmácia, Portugal
2012/12/06 - 2012/12/06 VII Jornadas monográficas de Química Farmacêutica. Pharmaceutical Sciences' students choose a topic of Medicinal Chemistry, design a poster communication that is presented on a meeting open to the general public. (2012/12/06 - 2012/12/06)
Encontro (Coorganizador)
 Universidade do Porto Faculdade de Farmácia, Portugal
2010/11/09 - 2010/11/10 V Scientific Congress AEFFUP (Students' Association of The Faculty of Pharmacy, University of Porto): "Antibiotherapy: a complementar approach" (2010/11/09 - 2010/11/10)
Congresso (Membro da Comissão Científica)
 Universidade do Porto Faculdade de Farmácia, Portugal
2009/07/19 - 2009/07/23 6th European Conference on Marine Natural Products (2009/07/19 - 2009/07/23)
Conferência (Outra)
 Universidade do Porto, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2024/11/14 - Atual Design fundamentals for Excellent Communication.
Oficina (workshop)
Museu da Faculdade de Belas Artes da Universidade do Porto, Portugal
2024/12/03 - 2024/12/06 High-throughput Proteomics Research Course.
Oficina (workshop)
2024/11/11 - 2024/11/14 Introductory Statistics with R for Biological Sciences.
Oficina (workshop)
Centro Interdisciplinar de Investigação Marinha e Ambiental da Madeira, Portugal
2024/09/22 - 2024/09/22 CIIMAR Open Day 2024. It is a day where the CIIMAR community receives all age visitors, with diverse activities aiming to communicate and disseminate the research projects and results to establish a closer relationship with the general public. I was involved in the creation and communication of "Bio-derived products and their applications" theme.
Outro
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2023/09/17 - 2023/09/17 CIIMAR Open Day 2023. It is a day where the CIIMAR community receives all age visitors, with diverse activities aiming to communicate and disseminate the research projects and results to establish a closer relationship with the general public. I was involved in the creation and communication of NIAF project about biofouling problematic and antifouling solutions.
Outro
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2023/01/13 - 2023/01/13 Day to day data management course.
Oficina (workshop)
BioData.pt, Portugal
2017/11/13 - 2017/11/17 European Students Sustainability Auditing (ESSA) Project - Audit in Kaunas University of Technology
Oficina (workshop)
Kauno technologijos universitetas, Lituânia
2017/09/06 - 2017/10/27 Controlled release drug delivery course (singular curricular unit)
Oficina (workshop)
Helsingin yliopisto Farmasian tiedekunta, Finlândia
2017/07/20 - 2017/07/29 Scientific illustration: Module III Black and White
Oficina (workshop)
Universidade do Porto Faculdade de Ciências, Portugal
2017/06/06 - 2017/06/08 Hands-on workshop on Image Analysis for Imaging flow Cytometry
Oficina (workshop)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/05/29 - 2017/05/29 Science, research integrity and responsibility
Simpósio
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/03/30 - 2017/04/08 Scientific illustration: Module II Black and White
Oficina (workshop)
Universidade do Porto Faculdade de Ciências, Portugal
2017/03/20 - 2017/03/24 European Students Sustainability Auditing (ESSA) Project: Training in University Social Responsibility Auditing
Oficina (workshop)
Universidade do Porto Faculdade de Psicologia e de Ciências da Educação, Portugal
2017/02/20 - 2017/03/07 Human Rights course
Oficina (workshop)
International Amnesty Portugal, Portugal
2016/06/14 - 2016/06/17 2nd Course on high content screening and image analysis for biosciences
Oficina (workshop)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/04/14 - 2016/04/17 8th Course on optical microscopy imaging for biosciences
Oficina (workshop)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/07/13 - 2015/07/19 Integrative structural biology tools for the study of protein-ligand interactions
Oficina (workshop)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/05/16 - 2011/05/24 Sixty-fourth World Health Assembly, Geneva, Switzerland
Encontro
Organisation mondiale de la Santé, Suiça
2009/07/06 - 2009/07/10 Medicinal Chemistry and HPLC course
Oficina (workshop)
Universidade do Porto Faculdade de Farmácia, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2019/11/13 MSc thesis: "Clinical EngineeringDeveloping new anticancer drug candidates by targeting p53", Master’s degree in Biomedical Engineering.
Arguente principal
 Joana Maria Alves da Silva (Mestrado)
Universidade do Minho, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2024/04/22 - 2024/04/22 ADMET in Medicinal Chemistry, Invited lecturer: "TXA1, a small molecules potent inhibitor of human tumor cell growth: synthesis and toxicological characterization". (1h) Mestrado em Química Farmacêutica (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2024/03/11 - 2024/03/11 Industrial Microbiology curricular unit, Invited Lecturer: "Genetic manipulation of microbial strains and production of recombinant proteins" (2h) 11 Mar 2024. Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2023/07/17 - 2023/07/21 Computational Chemistry - Pharmacophore screening (1h) Field trip MedChem Program: From Organic Chemistry to Pharmaceutical Drugs. Blended Intensive Programme (BIP) Universidade do Porto Faculdade de Farmácia, Portugal
2021/09/01 - 2022/08/31 Pharmaceutical Chemistry I and II (curricular units) Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2022/07/26 - 2022/07/29 Da matéria-prima ao medicamento: aprender a dar o 1.º passo Junior University, Summer Project (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2022/07/18 - 2022/07/22 Uma viagem pela química dos medicamentos Junior University, Summer Project (Outros) Universidade do Porto Faculdade de Farmácia, Portugal
2016 - 2022 Industrial Microbiology curricular unit, Invited Lecturer: "Use of microbial systems in the production of recombinant proteins" (2h), 10 Mai 2022; 22 Mar 2021; 15 Mar 2018; 1 Mar 2017; 16 Mar 2016 Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2019/09/01 - 2020/08/31 Pharmaceutical Chemistry I and II (curricular units) Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2019/09/01 - 2020/07/31 Pharmacology curricular unit Acupuntura (Licenciatura) Escola Superior de Enfermagem da Cruz Vermelha Portuguesa de Oliveira de Azeméis, Portugal
2020/05/12 - 2020/05/12 ADMET in Medicinal Chemistry, Invited lecturer: "TXA1, a small molecules potent inhibitor of human tumor cell growth: synthesis and toxicological characterization". (1h) Mestrado em Química Farmacêutica (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2015 - 2018 Industrial Microbiology curricular unit, Invited Lecturer: "Genetic manipulation of microbial strains and relevant genetic tools" (2h) 14 Mar 2018; 3 Mar 2016; 12 Mar 2015 Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal
2012/09/01 - 2016/02/28 Pharmaceutical Chemistry I and II (curricular units) Ciências Farmacêuticas (Mestrado integrado) Universidade do Porto Faculdade de Farmácia, Portugal

Membro de associação

Nome da associação Tipo de participação
2010/01/01 - 2010/12/31 Students' Association of Faculty of Pharmacy, University of Porto Communication Director
2009/01/01 - 2009/12/31 Students' Association pf Pharmacy Faculty, University of Porto Professional development and Internships Department

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2024/06/14 - 2024/06/14 Opponent of the MSc Seminar "Antifouling coatings: from biocidefree to non-release biocide coatings" by the student Catarina Campos Costa. MSc seminar is an evaluation on the state of the art of the master thesis topic, MSc in Medicinal Chemistry. Universidade do Porto Faculdade de Farmácia, Portugal
2024/01/31 - 2024/03/01 Evaluator in human resources call 2023_100_BPD_NIAF. Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2023/10/31 - 2023/11/30 Evaluator in human resources call 01-PAC_2023_101_BI_NIAF.
2023/07/25 - 2023/07/25 Opponent of the PhD Seminar "“ABC” of nature-inspired synthetic antifouling compounds: structure-activity relationship studies" by the student: Sara Jacinta Godinho Salgado. PhD seminar is an evaluation in the first year of research and state of the art review, PhD program in Pharmaceutical Sciences. Universidade do Porto Faculdade de Farmácia, Portugal
2022/12/15 - 2022/12/15 Jornadas Pedagógico-Científicas Madalena Pinto ‘22. Evaluation of the posters presented by the students. Universidade do Porto Faculdade de Farmácia, Portugal
2021/07/20 - 2021/07/20 Opponent of the PhD Seminar "Targeting p53 family and n-myc: alternative players for neuroblastoma therapy" by the student: Joana Filipa Duarte Almeida. PhD seminar is an evaluation in the first year of research and state of the art review, PhD program in Pharmaceutical Sciences. Universidade do Porto Faculdade de Farmácia, Portugal
2015/07/28 - 2015/07/28 Opponent of the Report of Project I curricular unit, of the Master in Pharmaceutical Sciences: "Synthesis of dyes with application in cytology diagnosis" by the student Iva Nogueira. Universidade do Porto Faculdade de Farmácia, Portugal

Tutoria

Tópico Nome do aluno
2024/04/29 - 2024/06/23 Development of biogenic hydrogels for marine antifouling application Margarita Brante
2023/03 - 2023/04 Xanthones: a possible therapeutic for Alzheimer's disease? Mariana Novais; Catarina Ribeiro
Distinções

Prémio

2023 1st Award, Scientist of the Year, Mauro Pinto, XVI National Congress of Scientists in Action, Estremoz, Portugal.
Centro Ciência Viva de Estremoz, Portugal
2019 MED.IDEAS award, with the project: ACTONp53: p53-activating agents as new anticancer drug candidates
NORTEXCEL, Portugal
2010 Hovione Award 2PYCheM - Paiva, M., Gomes, A., Cravo, S., Sousa, E., Pinto, M. New synthetic approaches using microwave radiation.
Hovione, Portugal
2008 2nd Award / New Talent Award. Mellor obra portuguesa / Jovens Talentos. Melhor obra portuguesa. VIII Bienal de Pintura Eixo Atlântico 2008-2009
Eixo Atlântico, Espanha