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For the past decade, my research has focused on understanding molecular mechanisms of neuro-regeneration and neuro-degeneration using in vitro primary neuronal cultures and in vivo mice models. My ambitious and highly innovative long-term goal is to elucidate key spatial and temporal signaling mechanisms, including axonal transport and local protein synthesis events, that are key in motor neuron survival and neuromuscular-junction maintenance under normal and pathological conditions such as ALS. I am highly motivated to lead my research team to perform high quality research and to make a significant contribution to scientific knowledge. I have the knowledge and technical skills that are required to accomplish the objectives set out here. I was fortunate to obtain a significant number of competitive grants from both national and international research foundations that provided essential background for the current application, specifically setting up a compartmental microfluidic platform of motor neuron-muscle co-culture system, and finding that muscle contribute to ALS pathology. I am the author of numerous publications and invited speaker to leading international meetings. I also serve as an ad-hoc reviewer to many international funding agencies, and scientific journals. Since my beginning of my independent PI position at October 2010 in TAU, I have mentored 3 Postdocs, 9 PhDs, 11 MSc graduate students and 19 undergraduate students. In parallel with my research efforts, I also teach both undergraduate and graduate courses for both life sciences and medical students and involve in numerous academic committees.
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Identificação

Identificação pessoal

Nome completo
ERAN PERLSON

Nomes de citação

  • PERLSON, ERAN
  • Perlson, E

Identificadores de autor

Ciência ID
531A-417B-3264
ORCID iD
0000-0001-6047-9613

Endereços de correio eletrónico

  • eranpe@tauex.tau.ac.il (Profissional)

Telefones

Telefone
  • (050) 5209194 (Profissional)
Formação
Grau Classificação
2005/08
Concluído
 Neuro-Biochemistry (Doctor)
Weizmann Institute of Science, Israel
"Retrograde injury signaling in lesioned neurons" (TESE/DISSERTAÇÃO)
2000/08
Concluído
 Molecular Biology (Master)
Ben-Gurion University, Israel
1997/08
Concluído
 Biology (Bachelor)
Tel Aviv University, Israel
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2005 - 2010 Pós-doutorado (Investigação) University of Pennsylvania Perelman School of Medicine, Estados Unidos
2006 - 2006 Investigador visitante (Investigação) Stanford University Medical center, Estados Unidos
2001 - 2001 Investigador visitante (Investigação) University of California San Francisco, Estados Unidos

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2018 - Atual Professor Associado (Docente Universitário) Tel-Aviv University Department. of Physiology and Pharmacology, Israel

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2011 - Atual Faculty member in Sagol School of Neuroscience Tel-Aviv University Sagol School of Neuroscience, Israel
2013 - 2019 Head of the Center for Neuro-Communication Tel-Aviv University Center for Neuro-Communication, Israel
2015 - 2018 Senior Lecturer, with tenure Tel-Aviv University, Israel
2015 - 2015 Guest associate Editor in Frontiers in Cellular Neurophysiology Frontiers Journals, Estados Unidos
2010 - 2015 Senior Lecturer, Dept. of Physiology and Pharmacology Tel-Aviv University, Israel
2012 - 2013 Guest associate Editor in Frontiers in Cellular Neuroscience Frontiers Journals, Estados Unidos
2011 - 2012 Reviewing Editor, eNeuro, SFN’s open access journal Society for Neuroscience, Estados Unidos
Projetos

Bolsa

Designação Financiadores
2020 - 2024 HFSP: Developing a method for rapid disassembly of neurodegenerative biomolecular condensates
0001
Investigador responsável
2019 - 2024 Israel Science Foundation: The Interplay between Local Synthesis and Axon/NMJ Maintenance and Degeneration in ALS
0001
Investigador responsável
2020 - 2023 JPND-Multinational research projects on Personalised Medicine for Neurodegerative Diseases: Humanized high-throughput co-culture system for motor neuron diseases
0001
Investigador responsável
2020 - 2022 Israel Innovation Authority (Kamin): ALS treatment by miR126-5P manipulations via lentivirsus
0001
Investigador responsável
2019 - 2021 Ministry of Science and Technology State of Israel, China-Israel flagship projects brain sciences: The mechanisms of BDNF-TrkB signaling in neurodegenerative disease
0001
Investigador responsável
2013 - 2018 European Research Council Starter Grant: The Molecular Communication Mechanism of Motor Neuron Survival and Synapse Maintenance.
0001
2017 - 2017 NOFAR: Developing a novel Neuromuscular Junction - multi electrode arrays (NMJ-MEA) platform for high-throughput synapse activity functional drug screening
0001
Investigador responsável
2017 - 2017 Israeli Defense Force: On-site treatment of crushed muscle due to prolonged pressure, aimed at decreasing damage extent and rapid regaining of physical competence
0001
Investigador responsável
2016 - 2017 IsrALS: The role of miR126 in ALS
0001
Investigador responsável
2013 - 2016 E-Rare-2, European Research Projects on Rare Diseases driven by Young Investigators: The Molecular Basis of Neurodegeneration and Muscle Atrophy in ALS
0001
Investigador responsável
2013 - 2016 Rosetrees Trust: Small Molecule Screen for Neuromuscular Junction Maintenance
0001
Investigador responsável
2011 - 2015 Marie Curie International Reintegration Grants (IRG): Retrograde Signaling
0001
Investigador responsável
2011 - 2015 Israel Science Foundation (ISF): The Dual Role of Dynein in GDNF Signaling
0001
Investigador responsável
2012 - 2014 US-Israel Binational Science Foundation (BSF): Axonal Motor Neuron Transcriptomes
0001
Investigador responsável
2012 - 2014 The Alfred Taubman Foundation: Microfluidic platform for motor neuron and muscle cells:
0001
Investigador responsável
2011 - 2014 The German Israeli Foundation for Scientific Research and Development: Molecular Mechanisms of Rabies Virus Transport
0001
Investigador responsável
2012 - 2013 Bathsheva de Rothchild workshop and Fellow:co-organizing, Spatial Challenges in Neuronal Cell Biology Meeting, Ein Bokek, Dead Sea April 2013
0001
Investigador responsável
2011 - 2013 The Dual Role of Dynein in GDNF Signaling: Equipment for new faculty member
0001
Investigador responsável
2011 - 2013 Israel Science Foundation Morasha -Legacy Heritage Biomedical Science:: Molecular Mechanisms of Neurodegeneration in ALS
0001
Investigador responsável
2011 - 2013 Internal TAU grant: The role of Dynein in ALS Neuromuscular Junction Maintenance
0001
2011 - 2012 Israeli association for ALS: Non-Autonomous Degeneration in ALS
0001
Investigador responsável
Produções

Publicações

Artigo em revista
  1. Topaz Altman; Danielle Geller; Elisabeth Kleeblatt; Tal Gradus-Perry; Eran Perlson. "An in vitro compartmental system underlines the contribution of mitochondrial immobility to the ATP supply in the NMJ". Journal of Cell Science (2019): jcs.234492-jcs.234492. https://doi.org/10.1242/jcs.234492.
    10.1242/jcs.234492
  2. Chein M; Perlson E; Roichman Y. "Flow Arrest in the Plasma Membrane.". Biophysical journal (2019): http://europepmc.org/abstract/med/31326106.
    10.1016/j.bpj.2019.07.001
  3. Maimon R; Perlson E. "Muscle secretion of toxic factors, regulated by miR126-5p, facilitates motor neuron degeneration in amyotrophic lateral sclerosis.". Neural regeneration research (2019): http://europepmc.org/abstract/med/30762002.
    10.4103/1673-5374.250571
  4. Granik N; Weiss LE; Nehme E; Levin M; Chein M; Perlson E; Roichman Y; Shechtman Y. "Single-Particle Diffusion Characterization by Deep Learning.". Biophysical journal (2019): http://europepmc.org/abstract/med/31280841.
    10.1016/j.bpj.2019.06.015
  5. Mella J; Pérez V; Zelada D; Moreno N; Ionescu A; Perlson E; Henríquez JP. "Efficient gene transfer into primary muscle cells to analyze nerve-independent postsynaptic organization in vitro.". Neuromuscular disorders : NMD (2019): http://europepmc.org/abstract/med/31230871.
    10.1016/j.nmd.2019.05.005
  6. Ionescu A; Gradus T; Altman T; Maimon R; Saraf Avraham N; Geva M; Hayden M; Perlson E. "Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1G93A Model.". Cell death & disease (2019): http://europepmc.org/abstract/med/30824685.
    10.1038/s41419-019-1451-2
  7. Barak R; Yom-Tov G; Guez-Haddad J; Gasri-Plotnitsky L; Maimon R; Cohen-Berkman M; McCarthy AA; et al. "Structural Principles in Robo Activation and Auto-inhibition.". Cell (2019): http://europepmc.org/abstract/med/30853216.
    10.1016/j.cell.2019.02.004
  8. Ionescu A; Perlson E. "Patient-derived co-cultures for studying ALS.". Nature biomedical engineering (2019): http://europepmc.org/abstract/med/30932066.
    10.1038/s41551-018-0333-8
  9. Gershoni-Emek N; Altman T; Ionescu A; Costa CJ; Gradus-Pery T; Willis DE; Perlson E. "Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS.". Frontiers in molecular neuroscience (2018): http://europepmc.org/abstract/med/30233312.
    10.3389/fnmol.2018.00311
  10. Pathak A; Stanley EM; Hickman FE; Wallace N; Brewer B; Li D; Gluska S; et al. "Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1.". Developmental cell (2018): http://europepmc.org/abstract/med/30086304.
    10.1016/j.devcel.2018.07.001
  11. Eitan Erez Zahavi; Noam Steinberg; Topaz Altman; Michael Chein; Yuvraj Joshi; Tal Gradus-Pery; Eran Perlson. "The receptor tyrosine kinase TrkB signals without dimerization at the plasma membrane". Science Signaling 11 529 (2018): eaao4006-eaao4006. https://doi.org/10.1126/scisignal.aao4006.
    10.1126/scisignal.aao4006
  12. Maimon R; Ionescu A; Bonnie A; Sweetat S; Wald-Altman S; Inbar S; Gradus T; et al. "miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS.". The Journal of Neuroscience (2018): http://europepmc.org/abstract/med/29773756.
    10.1523/JNEUROSCI.3037-17.2018
  13. Yardeni T; Fine R; Joshi Y; Gradus-Pery T; Kozer N; Reichenstein I; Yanowski E; et al. "High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria.". Scientific reports (2018): http://europepmc.org/abstract/med/29311649.
    10.1038/s41598-017-17878-x
  14. Zahavi EE; Maimon R; Perlson E. "Spatial-specific functions in retrograde neuronal signalling.". Traffic (Copenhagen, Denmark) (2017): http://europepmc.org/abstract/med/28393448.
    10.1111/tra.12487
  15. Naftelberg S; Ast G; Perlson E. "Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.". Neural regeneration research (2017): http://europepmc.org/abstract/med/28553323.
    10.4103/1673-5374.205082
  16. Rotem N; Magen I; Ionescu A; Gershoni-Emek N; Altman T; Costa CJ; Gradus T; et al. "ALS Along the Axons - Expression of Coding and Noncoding RNA Differs in Axons of ALS models.". Scientific reports (2017): http://europepmc.org/abstract/med/28300211.
    10.1038/srep44500
  17. Naftelberg S; Abramovitch Z; Gluska S; Yannai S; Joshi Y; Donyo M; Ben-Yaakov K; et al. "Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.". PLoS genetics (2016): http://europepmc.org/abstract/med/27997532.
    10.1371/journal.pgen.1006486
  18. Moya-Alvarado G; Gershoni-Emek N; Perlson E; Bronfman FC. "Neurodegeneration and Alzheimer's disease (AD). What Can Proteomics Tell Us About the Alzheimer's Brain?". Molecular & cellular proteomics : MCP (2015): http://europepmc.org/abstract/med/26657538.
    10.1074/mcp.R115.053330
  19. Bornstein B; Zahavi EE; Gelley S; Zoosman M; Yaniv SP; Fuchs O; Porat Z; Perlson E; Schuldiner O. "Developmental Axon Pruning Requires Destabilization of Cell Adhesion by JNK Signaling.". Neuron (2015): http://europepmc.org/abstract/med/26586184.
    10.1016/j.neuron.2015.10.023
  20. Gershoni-Emek N; Mazza A; Chein M; Gradus-Pery T; Xiang X; Li KW; Sharan R; Perlson E. "Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.". Molecular & cellular proteomics : MCP (2015): http://europepmc.org/abstract/med/26598648.
    10.1074/mcp.M115.049965
  21. Ionescu A; Zahavi EE; Gradus T; Ben-Yaakov K; Perlson E. "Compartmental microfluidic system for studying muscle-neuron communication and neuromuscular junction maintenance.". European journal of cell biology (2015): http://europepmc.org/abstract/med/26689471.
    10.1016/j.ejcb.2015.11.004
  22. Gluska S; Chein M; Rotem N; Ionescu A; Perlson E. "Tracking Quantum-Dot labeled neurotropic factors transport along primary neuronal axons in compartmental microfluidic chambers.". Methods in cell biology (2015): http://europepmc.org/abstract/med/26794524.
    10.1016/bs.mcb.2015.06.016
  23. Bauer A; Nolden T; Nemitz S; Perlson E; Finke S. "A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription.". Journal of virology (2015): http://europepmc.org/abstract/med/26157129.
    10.1128/JVI.01298-15
  24. Gluska S; Finke S; Perlson E. "Receptor-mediated increase in rabies virus axonal transport.". Neural regeneration research (2015): http://europepmc.org/abstract/med/26199597.
    10.4103/1673-5374.158337
  25. Gershoni-Emek N; Chein M; Gluska S; Perlson E. "Amyotrophic lateral sclerosis as a spatiotemporal mislocalization disease: location, location, location.". International review of cell and molecular biology (2015): http://europepmc.org/abstract/med/25708461.
    10.1016/bs.ircmb.2014.11.003
  26. Zahavi EE; Ionescu A; Gluska S; Gradus T; Ben-Yaakov K; Perlson E. "A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions.". Journal of cell science (2015): http://europepmc.org/abstract/med/25632161.
    10.1242/jcs.167544
  27. Bauer A; Nolden T; Schröter J; Römer-Oberdörfer A; Gluska S; Perlson E; Finke S. "Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons.". Journal of virology (2014): http://europepmc.org/abstract/med/25275124.
    10.1128/JVI.02254-14
  28. Dadon-Nachum M; Ben-Yaacov K; Ben-Zur T; Barhum Y; Yaffe D; Perlson E; Offen D. "Transplanted modified muscle progenitor cells expressing a mixture of neurotrophic factors delay disease onset and enhance survival in the SOD1 mouse model of ALS.". Journal of molecular neuroscience : MN (2014): http://europepmc.org/abstract/med/25330859.
    10.1007/s12031-014-0426-0
  29. Gluska S; Zahavi EE; Chein M; Gradus T; Bauer A; Finke S; Perlson E. "Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery.". PLoS pathogens (2014): http://europepmc.org/abstract/med/25165859.
    10.1371/journal.ppat.1004348
  30. Castle MJ; Perlson E; Holzbaur EL; Wolfe JH. "Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment.". Molecular therapy : the journal of the American Society of Gene Therapy (2013): http://europepmc.org/abstract/med/24100640.
    10.1038/mt.2013.237
  31. Yashunsky V; Kharilker L; Zlotkin-Rivkin E; Rund D; Melamed-Book N; Zahavi EE; Perlson E; et al. "Real-time sensing of enteropathogenic E. coli-induced effects on epithelial host cell height, cell-substrate interactions, and endocytic processes by infrared surface plasmon spectroscopy.". PloS one (2013): http://europepmc.org/abstract/med/24194932.
    10.1371/journal.pone.0078431
  32. Perlson E; Hendricks AG; Lazarus JE; Ben-Yaakov K; Gradus T; Tokito M; Holzbaur EL. "Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons.". The Journal of biological chemistry (2013): http://europepmc.org/abstract/med/23960070.
    10.1074/jbc.M113.465088
  33. Lilo E; Wald-Altman S; Solmesky LJ; Ben Yaakov K; Gershoni-Emek N; Bulvik S; Kassis I; et al. "Characterization of human sporadic ALS biomarkers in the familial ALS transgenic mSOD1(G93A) mouse model.". Human molecular genetics (2013): http://europepmc.org/abstract/med/23836781.
    10.1093/hmg/ddt325
  34. Hendricks AG; Lazarus JE; Perlson E; Gardner MK; Odde DJ; Goldman YE; Holzbaur EL. "Dynein tethers and stabilizes dynamic microtubule plus ends.". Current biology : CB (2012): http://europepmc.org/abstract/med/22445300.
    10.1016/j.cub.2012.02.023
  35. Hendricks AG; Perlson E; Ross JL; Schroeder HW; Tokito M; Holzbaur EL. "Motor coordination via a tug-of-war mechanism drives bidirectional vesicle transport.". Current biology : CB (2010): http://europepmc.org/abstract/med/20399099.
    10.1016/j.cub.2010.02.058
  36. Perlson E; Maday S; Fu MM; Moughamian AJ; Holzbaur EL. "Retrograde axonal transport: pathways to cell death?". Trends in neurosciences (2010): http://europepmc.org/abstract/med/20434225.
    10.1016/j.tins.2010.03.006
  37. Perlson E; Jeong GB; Ross JL; Dixit R; Wallace KE; Kalb RG; Holzbaur EL. "A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration.". The Journal of neuroscience : the official journal of the Society for Neuroscience (2009): http://europepmc.org/abstract/med/19657041.
    10.1523/JNEUROSCI.0813-09.2009
  38. Perlson E; Holzbaur EL. "Myosin learns to recruit AMPA receptors.". Cell (2008): http://europepmc.org/abstract/med/18984153.
    10.1016/j.cell.2008.10.013
  39. Perlson E; Michaelevski I; Kowalsman N; Ben-Yaakov K; Shaked M; Seger R; Eisenstein M; Fainzilber M. "Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase.". Journal of molecular biology (2006): http://europepmc.org/abstract/med/17046786.
    10.1016/j.jmb.2006.09.056
  40. Perlson E; Hanz S; Ben-Yaakov K; Segal-Ruder Y; Seger R; Fainzilber M. "Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve.". Neuron (2005): http://europepmc.org/abstract/med/15748847.
    10.1016/j.neuron.2005.01.023
  41. Perlson E; Hanz S; Medzihradszky KF; Burlingame AL; Fainzilber M. "From snails to sciatic nerve: Retrograde injury signaling from axon to soma in lesioned neurons.". Journal of neurobiology (2004): http://europepmc.org/abstract/med/14704959.
    10.1002/neu.10316
  42. Perlson E; Medzihradszky KF; Darula Z; Munno DW; Syed NI; Burlingame AL; Fainzilber M. "Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury.". Molecular & cellular proteomics : MCP (2004): http://europepmc.org/abstract/med/14973157.
    10.1074/mcp.m400004-mcp200
  43. Medzihradszky KF; Darula Z; Perlson E; Fainzilber M; Chalkley RJ; Ball H; Greenbaum D; et al. "O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes.". Molecular & cellular proteomics : MCP (2004): http://europepmc.org/abstract/med/14752058.
    10.1074/mcp.m300140-mcp200
  44. Hanz S; Perlson E; Willis D; Zheng JQ; Massarwa R; Huerta JJ; Koltzenburg M; et al. "Axoplasmic importins enable retrograde injury signaling in lesioned nerve.". Neuron (2003): http://europepmc.org/abstract/med/14687545.
    10.1016/s0896-6273(03)00770-0
Capítulo de livro
  1. Gershoni-Emek N; Zahavi EE; Gluska S; Slobodskoy Y; PERLSON, ERAN. "The Molecular Communication Mechanism of Neuron Survival and Synapse Maintenance". University of Chicago Press, 2015.
  2. PERLSON, ERAN; Holzbaur EL. "The Role of Molecular Motors in Axonal Transport. in Protein Trafficking in the Neuron". Andrew Bean editor. Elsevier Publishing, 2007.

Propriedade Intelectual

Patente
  1. PERLSON, ERAN; Ionescu A; Gradus T; Roy Maimon. 2018. "Spatial treatment of mIR126. Ramot, US Provisional Patent Application. RAMOT/084 USP: 62/671,460; RAMOT/084 USP-1: 62/671,463".
  2. PERLSON, ERAN; Ionescu A; Gradus T; Michaelevski I. 2017. "A Novel Drug High-throughput Synapse Activity Functional Screening Device. Ramot".
  3. Fainzilber M; Hanz S; PERLSON, ERAN. 2006. "Neuronal regeneration and compound administration methods. Yeda Research and Development".
  4. Burlingame A.L; Medzihradszky K.F; Darula Z; PERLSON, ERAN; Fainzilber M.; Chalkley R.J; Tyson D.; Bradshaw R.A. 2005. "Protein O-sulfonation, US 20050054020, US 20070059771".

Outros

Outra produção
  1. Sema3A Facilitates a Retrograde Death Signal via CRMP4-Dynein Complex Formation in ALS Motor Axons. 2019. Maimon R; Ankol L; Weissova R; Tank E; Pery TG; Opatowsky Y; Barmada S; Balastik M; Perlson E. http://europepmc.org/abstract/PPR/PPR92984.
    10.1101/774737
  2. Uncoating of COPII from ER exit site membranes precedes cargo accumulation and membrane fission. 2019. Shomron O; Nevo-Yassaf I; Aviad T; Yaffe Y; Zahavi EE; Dukhovny A; Perlson E; et al. http://europepmc.org/abstract/PPR/PPR87972.
    10.1101/727107
  3. Flow arrest in the plasma membrane. 2019. Michael Chein; Eran Perlson; Yael Roichman. https://doi.org/10.1101/575456.
    10.1101/575456
  4. Single particle diffusion characterization by deep learning. 2019. Granik N; Nehme E; Weiss LE; Levin M; Chein M; Perlson E; Roichman Y; Shechtman Y. http://europepmc.org/abstract/PPR/PPR74098.
    10.1101/588533
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020 Intrinsic mechanisms of size & growth regulation in neurons
(Rehovot, Israel)
2020 ISFN, Israeli neuroscience meeting
(Eilat, Israel)
2020 NeuroFluidics, Neuroscience &Microfluidics
(Montpellier, França)
2019 HSFN, The Hellenic Society for Neuroscience meeting
(Heraklio, Crete, Grécia)
2019 Gordon Conference on Neurotrophic Factors
(Newport, RI, Estados Unidos)
2019 China-Israel Ministries of Science Flagship Projects in Brain Sciences, Tsinghua University
(Beijing, China)
2019 Semaphorins: from bench to bedside, Faculty of Medicine, Technion,
(Haifa, Israel)
2018 Israel France scientific workshop: Novel tools and technologies for neuroscience research, Yehuda Hotel,
(Jerusalem, Israel)
2018 BIRAX aging conference, King’s College London
(London, Reino Unido)
2018 Next generation of ALS research, Ben-Gurion University
(Israel)
2018 Mini symposium on neuron mechanics and growth, Hebrew University of Jerusalem
(Jerusalem, Israel)
2018 Brain Research Institute, University of Zurich
(Zurich, Suiça)
2018 Neuronal Interfaces Meeting Bar-Ilan
(Israel)
2017 NeuroFluidics meeting
(Grenoble, França)
2017 ERC consolidator research panel
(Brussels, Bélgica)
2017 FEBS congress
(Jerusalem, Israel)
2017 Gordon Conference on Neurotrophic Factors
(Newport, RI, Estados Unidos)
2017 EMBO Conference, Cell Biology of the Neuron: Polarity, Plasticity and Regeneration,
(Heraklion, Grécia)
2017 China-Israel Joint Seminar on Brain Science and Brain-Inspired Intelligence Technology Cooperation.
(Beijing, China)
2017 Soft and Biological Matter, The joint Tel-Aviv University-ESPCI Paris Workshop
(PARIS, França)
2017 New Frontiers in ALS Research meeting, Weizmann Institute
(Israel)
2017 Ilanit/FISEB meeting
(Eilat, Israel)
2016 Keystone Symposia, Axons: From Cell Biology to Pathology
(NM, Estados Unidos)
2016 E-Rare Monitoring Meeting
(Barcelona, Espanha)
2016 EMBO workshop on Mechanisms of Neuronal Remodeling
(Seeon, Alemanha)
2016 Institute of Physiology
(República Checa)
2016 University of Michigan
(Ann Harbor, Michigan, Estados Unidos)
2016 Rutgers University
(Rutgers, NJ, Estados Unidos)
2016 Thomas Jefferson University
(Philadelphia, Estados Unidos)
2016 Weill Cornell Medicine
(White Plains, NY, Estados Unidos)
2015 TAU-CRG Biomed Symposium, Gene Regulation, Genomics and Stem Cells in Disease
(Tel-Aviv,, Israel)
2015 Institute de Génétique Moléculaire de Montpellier
(Montpellier, França)
2015 EMBO Workshop, Emerging concepts of the neuronal cytoskeleton
(Puerto Varas, Chile)
2015 The Pontifical Catholic University of Chile Santiago
(Santiago, Chile)
2015 University of Concepcion
(Concepcion, Chile)
2015 Gordon Conference on Neurotrophic Factors
(Newport, RI, Estados Unidos)
2015 Gordon Conference on Infectious of the nervous system
(Hong Kong)
2015 Third Annual Broad-ISF Cell Circuits Symposium
(Jerusalem, Israel)
2015 Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Science
(Warsaw, Polónia)
2014 The Switzerland Institute of Developmental Biology
(Tel-Aviv, Israel)
2014 Cold Spring Harbor ASIA Conference, NGF2014 Joint conference on Nerve Growth Factor and Related Neurotrophic Factors: Emerging Concepts, New Mechanisms, Novel Technologies
(Suzho,, China)
2014 Israel Society for Neuroscience
(Eilat, Israel)
2014 Friedrich-Loeffler-Institute
(Greifswald-Insel Riems, Alemanha)
2012 Neuronal Circuit Development, Institute Curie
(PARIS, França)
2012 Friedrich-Loeffler-Institute
(Greifswald-Insel Riems, Alemanha)
2012 CNCR, VU university
(Amsterdam, Países Baixos)
2012 American Society for Cell Biology, (ASCB)
(San-Francisco, Estados Unidos)
2011 Gordon Conference on Neurotrophic Factors
(Newport, RI, Estados Unidos)
2011 Chilean Society for cell biology meeting ,
(Puerto Varas, Chile)
2010 ISF-Legacy Symposium on New approaches to Neurodegenerative Diseases
(Dead Sea, Israel)
2009 Gordon Conference on Neurotrophic Factors
(Newport, RI, Estados Unidos)
2008 NGF Meeting
(Kfar Blum, Israel)
2006 ALS Association [ALSA)
(St. Petersburg, FL, Estados Unidos)
2002 The first meeting on Molecular Aspects of Axonal Transport, Nerve Growth and Regeneration
(Rostock-Warnemunde, Alemanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019 - Atual Ph.D. student: Local synthesis in ALS
Orientador
2018 - Atual M.Sc. student: Exosome regulation in ALS
Orientador
2018 - Atual M.Sc. student: The role of miR126 in ALS pathology
Orientador
2018 - Atual M.Sc. student: The spatial role of miR126 in motor neuron function
Orientador
2016 - Atual Ph.D. student: Mechanism of axonal RNA localization
Orientador
2016 - Atual MD/Ph.D student: Toxic metabolic pathways in ALS
Orientador
2018 - 2019 Postdoctoral fellows: Single particle analysis of TrkB diffusion along the plasma membrane
Orientador
2018 - 2019 M.Sc. student: The role of muscle in ALS toxicity
Orientador
2015 - 2019 Ph.D. student: The Role of Semaphorin in ALS
Orientador
2016 - 2018 M.Sc. student:: Drug screening for miRNA expression in ALS
Orientador
2015 - 2018 M.Sc. student: Spatiotemporal neurotrophic signaling events
Orientador
2013 - 2018 Ph.D. student: The Role of BDNF signaling in ALS
Orientador
2014 - 2016 M.Sc. student: Mechanism of Neuromuscular Junction disruption in ALS
Orientador
2014 - 2016 M.Sc. student: The Role of Semaphorin in ALS
Orientador
2014 - 2016 M.Sc. student: Molecular mechanisms in ALS pathology
Orientador
2011 - 2016 Ph.D. student: microRNA Transport in Axons of Motor Neurons: Implications in Health and Disease
Orientador
2011 - 2016 Ph.D. student: Molecular Mechanisms of Neurotrophic Receptors Dynamics Along the cell Surface
Orientador
2013 - 2015 M.Sc. student: Axonal RNAs Role in ALS
Orientador
2011 - 2015 MD/Ph.D student: Rabies Virus and GDNF Retrograde Signaling in the Motor Neuron
Orientador
2012 - 2014 M.Sc. student: The Role of Semaphorin in Motor Neuron Disease
Orientador
2011 - 2013 Postdoctoral fellows: The Role of Dynein in NMJ Maintenance
Orientador

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2020 - 2020 Co-Organizer, Intrinsic mechanisms of size & growth regulation in neurons Weizmann Institute, Israel (2020 - 2020)
2020 - 2020 Organizer, NMJ-on-a-Chip one day meeting, Tel-Aviv Israel (2020 - 2020)
2020 - 2020 Orgnizer, RNA localization one day meeting, Tel-Aviv Israel (2020 - 2020)
2020 - 2020 Co-Orgenizer, Exploring the Brain: From Molecule to Neuron”, Tel-Aviv Israel (2020 - 2020)
2014 - 2018 Co-organizer of Sagol school for Neuroscience seminars (2014 - 2018)
2012 - 2018 Co-organizer and founder of the Annual Israeli Forum for Cytoskeleton Motility (2012 - 2018)
2016 - 2017 Co-program Committee, The Fred Chaoul 11th Annual Nano Workshop, Dead Sea, Israel (2016 - 2017)
2012 - 2017 Co-organizer of the Israeli Forum for Cytoskeleton Motility (2012 - 2017)
2013 - 2013 Co-Organizer, Opening Plenary and Session Chair, Batsheva Workshop on Spatial Challenges in Neuronal Cell Biology, Rehovot, Israel (2013 - 2013)
2010 - 2013 Organizer of the Physiology and Pharmacology Departmental Seminar (2010 - 2013)

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2011 - Atual Journal of Cell Science (1477-9137) The Company of Biologists
2010 - Atual Frontiers in Cellular Neuroscience (1662-5102) Frontiers Media SA
2010 - Atual Frontiers in Cellular Neurophysiology
2010 - Atual eNeuro (2373-2822) Society for Neuroscience
2010 - Atual Neuron (0896-6273) Elsevier
2010 - Atual Science Signaling (1937-9145) American Association for the Advancement of Science (AAAS)
2010 - Atual Science Advances
2010 - Atual iScience (2589-0042) Elsevier
2010 - Atual Journal of Neuroscience
2010 - Atual Nature Communication
2010 - Atual Nature Protocols (1754-2189) Springer Science and Business Media LLC
2010 - Atual EMBO
2010 - Atual EMBO medicine
2010 - Atual eLife (2050-084X) "eLife Sciences Publications, Ltd."
2010 - Atual Human Molecular Genetics (1460-2083) Oxford University Press
2010 - Atual Journal of Biological Chemistry (1083-351X) American Society for Biochemistry and Molecular Biology
2010 - Atual Biophysical Journal (1542-0086) Elsevier
2010 - Atual Journal of Virology
2010 - Atual Cellular and Molecular Neurobiology (1573-6830) Springer-Verlag
2010 - Atual Journal of General Virology (1465-2099) Microbiology Society
2010 - Atual Neurodegenerative Diseases (1660-2862) S. Karger AG
2010 - Atual Journal of Neuroscience and Rehabilitation (2374-9091) "ScienceScript, LLC"
2010 - Atual PeerJ (2167-8359) PeerJ
2010 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2010 - Atual Cellular Microbiology (1462-5822) Wiley (Blackwell Publishing)
2010 - Atual Journal of Biological Physics (1573-0689) Springer-Verlag
2010 - Atual Neurosignals (1424-8638) Cell Physiol Biochem Press GmbH and Co KG
2010 - Atual Journal of Theoretical Biology (1095-8541) Elsevier
2010 - Atual Journal of Neurochemistry (1471-4159) Wiley (Blackwell Publishing)
2010 - Atual Cytoskeleton (1949-3592) Wiley (John Wiley & Sons)
2010 - Atual PLoS ONE (1932-6203) Public Library of Science
2010 - Atual Frontiers in Molecular Neuroscience (1662-5099) Frontiers Media SA
2010 - Atual Molecular & Cellular Proteomics (1535-9484) American Society for Biochemistry and Molecular Biology
2010 - Atual Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (0925-4439) Elsevier
2010 - Atual AIMS Molecular Science (2372-028X) American Institute of Mathematical Sciences
2010 - Atual Journal of Controlled Release (0168-3659) Elsevier
2010 - Atual AJP: Cell Physiology
2010 - Atual PROTEOMICS (1615-9861) Wiley (John Wiley & Sons)
2010 - Atual ACS Chemical Neurosicence
2010 - Atual Neural Regeneration Research (1673-5374) Medknow Publications
2010 - Atual Nucleic Acids Research (1362-4962) Oxford University Press

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2013 - Atual Molecular Mechanisms of Neuro-communication
2011 - Atual Endocrinology (Part of Physiology course)
2011 - Atual Molecular Neurobiology
2011 - Atual Neurohistology Lab
2010 - 2014 Scientific writing

Membro de associação

Nome da associação Tipo de participação
2007 - Atual American Society for Cell Biology
2001 - Atual Society for Neuroscience
2001 - Atual Israeli Society for Biochemistry and Molecular Biology
2001 - Atual Israeli Society for Neuroscience

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2018 - Atual Chair of Sagol school of neuroscience MSc committee
2018 - Atual Panel member in Sagol school of neuroscience "management forum”
2016 - Atual Panel member in TAU Research and development committee
2013 - Atual Graduate students committee Member
2010 - Atual Reviewer for Funding agency: Fondation maladies rares
2010 - Atual Reviewer for Funding agency: MRC, Medical Research Council, UK
2010 - Atual Reviewer for Funding agency: ANR, National Agency for Research, France
2010 - Atual Reviewer for Funding agency: BSF, US-Israel Binational Science Foundation
2010 - Atual Reviewer for Funding agency: ISF, Israel Science Foundation
2010 - Atual Reviewer for Funding agency: GIF, German-Israeli Foundation for Scientific Research and Development
2010 - Atual Reviewer for Funding agency: MNDA, Motor Neuron Disease Association
2010 - Atual Reviewer for Funding agency: Neurological Foundation of New Zealand
2010 - Atual Reviewer for Funding agency: Alzheimer's Research UK
2010 - Atual Reviewer for Funding agency: Israel Ministry of Health
2010 - Atual Reviewer for Funding agency: Israel Ministry of Science
2010 - Atual Reviewer for Funding agency: ARSLA, French research association on ALS
2010 - Atual Reviewer for Funding agency: BBSRC, UK Research and Innovation
2017 - 2019 Panel member in Israeli Society for Neuroscience board committee
2016 - 2019 Chair of TAU committee for Inter-departmental equipment
2014 - 2017 Panel member in TAU Nano-Center post-doc committee
2013 - 2016 Panel member in the Research Advisory Council, GRTF; TAU Global, Research & Training Fellowship in Medical and Life Sciences Fund and Naomi Kadar Foundation
2012 - 2016 Evaluation adviser in MOR national institute for testing & evaluation for MD candidates
2013 - 2014 Panel member in the Research Advisory Council, US-Israel Binational Science Foundation
2013 - 2014 Panel member in the Research Advisory Council, Israeli Ministry of Health

Tutoria

Tópico Nome do aluno
2017 - 2018 International visiting student to my lab: Elisabeth Kleeblatt Elisabeth Kleeblatt
2017 - 2017 International visiting student to my lab: Wiebke Rehorst Wiebke Rehorst
2016 - 2016 International visiting student to my lab: Cristina Pinto Cristina Pinto
2016 - 2016 International visiting student to my lab: Magnus Kummerfeld Magnus Kummerfeld
2016 - 2016 International visiting student to my lab: Artyom Komissarov Artyom Komissarov
2015 - 2015 International visiting student to my lab: Vivian Perez Vivian Perez
2014 - 2014 International visiting student to my lab: Anja Bauer Anja Bauer
Distinções

Prémio

2010 Sieratzki-Korczyn Prize for Advances in Neuroscience
2008 The Muscular Dystrophy Association, Development Grant
2005 The Milton Safenowitz Post-Doctoral Fellowship for ALS Research