???global.info.a_carregar???
Identificação

Identificação pessoal

Nome completo
Lara Patrícia Marcos da Silva

Nomes de citação

  • Marcos-Silva L

Identificadores de autor

Ciência ID
571C-1747-BECC
ORCID iD
0000-0003-0212-8078
Scopus Author Id
55613775300
Formação
Grau Classificação
2014
Concluído
 PhD in Biomedicine (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Mucin MUC16 - CA125 cancer biomarker: biological functions and development of new biomarker assays" (TESE/DISSERTAÇÃO)
 Approved with distinction
2007
Concluído
 Biologia Celular e Molecular (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
" Three-dimensional porous chitosan matrices: fibronectin adsorption and microvasculature endothelial cell culture " (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/10/01 - Atual Investigador (Investigação) Instituto de Biologia Experimental e Tecnológica, Portugal
2007/03/02 - 2007/07/31 Estagiário de Investigação (Investigação) Instituto Nacional de Engenharia Biomédica, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/10/01 - Atual Scientist Instituto de Biologia Experimental e Tecnológica, Portugal
2018 - 2018 Scientist iNOVA4Health, Portugal
2016 - 2017 Scientist iNOVA4Health, Portugal
2016/05/01 - 2016/09/30 Postdoc Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2014/12/01 - 2015/06/30 Postdoc Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2014/01/01 - 2014/11/30 Fellowship researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2010/01/01 - 2013/12/31 PhD Student Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Dinamarca
2008/10/27 - 2009/12/31 Fellowship Researcher Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Dinamarca
2007/09/01 - 2009/12/31 Fellowship Researcher Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projetos

Bolsa

Designação Financiadores
2016/05 - 2016/09 Relevance of tumour heterogeneity for development of strategies to inhibit peritoneal Carcinomatosis.
NORTE-01-0145-FEDER-000029
 Norte2020
Produções

Publicações

Artigo em revista
  1. Maria J. Sebastião; Lara Marcos-Silva; Patrícia Gomes-Alves; Paula M. Alves. "Proteomic and Glyco(proteo)mic tools in the profiling of cardiac progenitors and pluripotent stem cell derived cardiomyocytes: Accelerating translation into therapy". Biotechnology Advances 49 (2021): 107755-107755. http://dx.doi.org/10.1016/j.biotechadv.2021.107755.
    10.1016/j.biotechadv.2021.107755
  2. Divya Thomas; Satish Sagar; Xiang Liu; Hye-Rim Lee; James A. Grunkemeyer; Paul M. Grandgenett; Thomas Caffrey; et al. "Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer". Molecular Therapy 29 4 (2021): 1557-1571. http://dx.doi.org/10.1016/j.ymthe.2020.12.029.
    10.1016/j.ymthe.2020.12.029
  3. Silva, Lara. "Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours". International Journal of Molecular Sciences (2018): http://www.mdpi.com/1422-0067/19/7/2045.
    10.3390/ijms19072045
  4. Ricardo, S.; Marcos-Silva, L.; Valente, C.; Coelho, R.; Gomes, R.; David, L.. "Mucins MUC16 and MUC1 are major carriers of SLeaand SLexin borderline and malignant serous ovarian tumors". Virchows Archiv 468 6 (2016): 715-722. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961842101&partnerID=MN8TOARS.
    10.1007/s00428-016-1929-6
  5. Ricardo, S.; Marcos-Silva, L.; David, L.. "Mucin carriers of TF in ovarian cancer". Journal of Cancer Research and Clinical Oncology 142 8 (2016): 1867-1868. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976333418&partnerID=MN8TOARS.
    10.1007/s00432-016-2186-4
  6. Ricardo, S.; Marcos-Silva, L.; Pereira, D.; Pinto, R.; Almeida, R.; Söderberg, O.; Mandel, U.; et al. "Detection of glyco-mucin profiles improves specificity of MUC16 and MUC1 biomarkers in ovarian serous tumours". Molecular Oncology 9 2 (2015): 503-512. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921309842&partnerID=MN8TOARS.
    10.1016/j.molonc.2014.10.005
  7. Marcos-Silva, L.; Ricardo, S.; Chen, K.; Blixt, O.; Arigi, E.; Pereira, D.; Høgdall, E.; et al. "A novel monoclonal antibody to a defined peptide epitope in MUC16". Glycobiology 25 11 (2015): 1172-1182. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946146517&partnerID=MN8TOARS.
    10.1093/glycob/cwv056
  8. Ruvoën-Clouet, N.; Magalhaes, A.; Marcos-Silva, L.; Breiman, A.; Figueiredo, C.; David, L.; Pendu, J.L.. "Increase in genogroup II.4 norovirus host spectrum by CagA-positive helicobacter pylori infection". Journal of Infectious Diseases 210 2 (2014): 183-191. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903978180&partnerID=MN8TOARS.
    10.1093/infdis/jiu054
  9. Marcos-Silva, L.; Narimatsu, Y.; Halim, A.; Campos, D.; Yang, Z.; Tarp, M.A.; Pereira, P.J.B.; et al. "Characterization of binding epitopes of CA125 monoclonal antibodies". Journal of Proteome Research 13 7 (2014): 3349-3359. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903719796&partnerID=MN8TOARS.
    10.1021/pr500215g
  10. Silva, Lara. "Kinetics and isotherm of fibronectin adsorption to three-dimensional porous chitosan scaffolds explored by ¹²5I-radiolabelling". (2013): http://www.ncbi.nlm.nih.gov/pubmed/23635535#.
    10.4161/biom.24791
  11. Chen, K.; Gentry-Maharaj, A.; Burnell, M.; Steentoft, C.; Marcos-Silva, L.; Mandel, U.; Jacobs, I.; et al. "Microarray glycoprofiling of CA125 improves differential diagnosis of ovarian cancer". Journal of Proteome Research 12 3 (2013): 1408-1418. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874587039&partnerID=MN8TOARS.
    10.1021/pr3010474
  12. Steentoft, C.; Vakhrushev, S.Y.; Joshi, H.J.; Kong, Y.; Vester-Christensen, M.B.; Schjoldager, K.T.-B.G.; Lavrsen, K.; et al. "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology". EMBO Journal 32 10 (2013): 1478-1488. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878644998&partnerID=MN8TOARS.
    10.1038/emboj.2013.79
  13. Silva, L.M.; Carvalho, A.S.; Guillon, P.; Seixas, S.; Azevedo, M.; Almeida, R.; Ruvoën-Clouet, N.; et al. "Infection-associated FUT2 (Fucosyltransferase 2) genetic variation and impact on functionality assessed by in vivo studies". Glycoconjugate Journal 27 1 (2010): 61-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749280085&partnerID=MN8TOARS.
    10.1007/s10719-009-9255-8
Distinções

Outra distinção

2017 Travel grant
2017 ESACT Grant
2009 FCT PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal