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I am a neuroscientist with over 15 years of experience in research. I have contributed to understanding the molecular and cellular mechanisms underlying adult neurogenesis and brain plasticity and their modulation by lifestyle. I am currently leading different projects focused on microglia involvement in adult neurogenesis and the generation of a human cellular platform for personalized medicine. I graduated from the University of Salamanca in 2001 with a degree in Biochemistry and completed my PhD at the Institute of Neuroscience of Castilla y León (INCyL, 2001-2007) in 2007 under the supervision of Dr. Alonso and Dr. Weruaga. My thesis focused on plasticity and neurodegeneration in the olfactory bulb and resulted in 9 publications and a patent. During my first postdoctoral stage (2007-2008), I spent 9 months at the laboratory of Dr. Cooper (King's College of London, UK) studying adult neurogenesis in animal models and human brain samples of Batten's disease. Then (2008-2011), I continued my postdoctoral studies at the laboratory of Dr. Saura (Institute of Neuroscience, Autonoma University of Barcelona), where we demonstrated that environmental stimulation prevents cognitive deficits and increases adult neurogenesis in a mouse model of Alzheimer's disease (AD). I also participated in revealing the role of CRTC1 (CREB-regulated transcription coactivator-1) in memory (two papers in J. Neuroscience). In 2011, I moved to the laboratory of Dr. Malva (Center for Neuroscience and Cell Biology, University of Coimbra, Portugal). We demonstrated that an acute and systemic inflammatory stimulus induces a long-term decrease in neurogenesis and memory. In 2014, I was the principal investigator of a project (2014-2015) related to the influence of diet on adult neurogenesis. I also contributed to analyzing the effects of hyperglycemia and a dietetic supplement in adult neurogenesis in an AD mouse model. In 2015, I joined the Achucarro Basque Center for Neuroscience as an Ikerbasque Research Fellow, co-leading research projects with Dr. Sierra to analyze the effects of phagocytic microglia on adult neurogenesis (J. Neuroscience). I also studied the impact of a balanced and deficient diet on omega-3 (Int. J. Mol Sci. 2022) and developed image analysis tools. In 2021, I joined the Neuronal Plasticity and Neurorepair group at the INCyL. I have been an Associate professor at the University of Salamanca since 2022. Here, I analyze lifestyle factors and disease effects on the brain and study the integration of bone marrow-derived cells in the central nervous system. SCIENTIFIC CONTRIBUTION. 3 six-year research periods awarded. Participation in 17 research projects, leading 7 (3 from the Spanish and 2 from the Portugal governments, 1 from Interreg Europe, and 1 from a private foundation I have been a member of the editorial board of two research journals and reviewed manuscripts for more than 20 journals. At the end of 2021, I received the i3 excellence certificate from the Spanish government. I have an extensive network of collaborations, many of which have been consolidated through ongoing or past research projects. I am also actively involved in science communication and outreach, co-organizing events such as the Pint of Science Festival and giving talks and writing (Investigación y Ciencia 2017 and The Conversation 2020) to a variety of audiences. I have supervised 9 Master's and 5 PhD students and have a track record of working with graduate students and postdoctoral fellows.
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Identificação

Identificação pessoal

Nome completo
Jorge Valero Gómez-Lobo

Nomes de citação

  • Valero, Jorge

Identificadores de autor

Ciência ID
5C16-913C-A76D
ORCID iD
0000-0001-6072-3313

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Catalão Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Inglês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Português Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B2)
Formação
Grau Classificação
2007
Concluído
 Neuroscience (Doctor)
Universidad de Salamanca, Espanha
"Mitral cell degeneration and its effects on adult neurogenesis in the olfactory bulb of the pcd mutant mouse" (TESE/DISSERTAÇÃO)
 Maximum qualification: Sobresaliente "cum laude"
2003
Concluído
 Minor Thesis (Outros)
Universidad de Salamanca, Espanha
2001
Concluído
 Bachelor in Biochemistry (Licenciatura)
Universidad de Salamanca, Espanha
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/05/01 - Atual Investigador (Investigação) Universidad de Salamanca, Espanha
Institute for Neuroscience of Castilla y León, Espanha
(...)
2020/06/01 - 2021/04/30 Investigador principal (carreira) (Investigação) Universidad del Pais Vasco Centro Achucarro, Espanha
Universidad del Pais Vasco Centro Achucarro, Espanha
2015/06/01 - 2020/05/31 Investigador (Investigação) Ikerbasque Basque Foundation for Science, Espanha
2013/10/01 - 2015/05/31 Investigador principal convidado (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2008/04/01 - 2011/03/31 Pós-doutorado (Investigação) Universitat Autònoma de Barcelona, Espanha
2007/04/01 - 2007/07/04 Investigador Contratado (Investigação) Universidad de Salamanca - Campus Miguel de Unamuno, Espanha
2006/02/01 - 2006/05/30 Investigador Contratado (Investigação) Universidad de Salamanca - Campus Miguel de Unamuno, Espanha

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/11/28 - Atual Professor Associado (Docente Universitário) Universidad de Salamanca, Espanha
2019/07/17 - 2021/04/30 Professor Visitante (Docente Universitário) Universidad del País Vasco, Espanha
Universidad del País Vasco Departamento de Neurociencias, Espanha
2020/09/28 - 2021/02/05 Professor Auxiliar (Docente Universitário) Universidad Europea del Atlántico, Espanha
Universidad Europea del Atlántico Facultad de Ciencias de la Salud, Espanha

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/04/01 - 2013/09/30 FCT Postdoctoral fellow Fundação para a Ciência e a Tecnologia, Portugal
2008/01/01 - 2008/03/31 Contracted as Collaborative investigator King's College London School of Medical Education, Reino Unido
2007/07/01 - 2007/12/31 Short-term postdoctoral fellow. Grant supported by “Fundación Alicia Koplowitz”. Fundación Alicia Koplowitz, Espanha
2002/01/01 - 2005/12/31 PhD student Research fellow Ministerio de Educación, Cultura y Deporte del Gobierno de España, Espanha
2000/10/01 - 2001/07/31 Undergraduate fellow. Collaborative grant. Ministerio de Educación, Cultura y Deporte del Gobierno de España, Espanha
Projetos

Bolsa

Designação Financiadores
2024/01/01 - 2026/12/31 Cooperação e transferência tecnológica para o desenvolvimento de uma nova plataforma de medicina de precisão para a Esclerose Lateral Amiotrófica
0145_CROSS_3DTOOL_4ALS_3_P
Investigador responsável
Universidad de Salamanca, Espanha
2023/01 - 2026/12 Modulating microglia-neuron crosstalk in Alzheimer’s disease
AARG-22-968879
Investigador
Alzheimer's Association
2023/08/01 - 2026/09/30 Microglial modulation of Environmental (E)stimulation effects on adult neurogenesis.
PID2022-140525NB-I00
Investigador responsável
Universidad de Salamanca, Espanha
2023/11/01 - 2025/10/31 Collaborative learning and innovative teaching for brain drug screening.
2023-1-PL01-KA220-HED-000160284
Investigador responsável
Universidad de Salamanca, Espanha
2022/06/01 - 2023/12/31 Mitochondria as potential drivers of sex-specific microglia dysfunctional remodeling and anxiety caused by prenatal stress.
EXPL/MED-NEU/1002/2021
Investigador
Universidade de Coimbra, Portugal
2020/11 - 2023/09 Epigenetic and functional reprogramming in microglia
PIBA_2020_1-0030
Investigador
Gobierno Vasco
2021 - 2023 Cell therapy in a model of cerebellar ataxia, selection and improvement of the cell line with the greatest neuroprotective potential
SA0129P20
Bolseiro de Investigação
Institute for Neuroscience of Castilla y León, Espanha

Universidad de Salamanca, Espanha
Em curso
2019/01/01 - 2022/12/31 Immunometabolic control of microglial phagocytosis
RTI2018-099267-B-I00
Co-Investigador Responsável (Co-IR)
Universidad del Pais Vasco Centro Achucarro, Espanha
 Ministerio de Ciencia, Innovación y Universidades.
Em curso
2019/01/01 - 2021/12/31 Mechanisms of microglial phagocytiosis disfunction in stroke: the role of autophagy
Fundación Tatiana Pérez de Guzmán el Bueno
Co-Investigador Responsável (Co-IR)
Universidad del Pais Vasco Centro Achucarro, Espanha
 Fundación Tatiana Pérez de Guzmán el Bueno
Em curso
2017/01 - 2019/12 Microglial phagocytosis in the healthy and diseased brain: from neurogenesis to neurodegeneration
PI_2016_1_0011
BFU2015-66689-R
Co-Investigador Responsável (Co-IR)
Universidad del Pais Vasco Centro Achucarro, Espanha
 Gobierno Vasco

Ministerio de Economía y Competitividad
Concluído
2017/01/01 - 2017/12/31 Clean to repair: new drugs to potentiate microglial phagocytosis
BBVA
Investigador
Universidad del Pais Vasco Centro Achucarro, Espanha
 Fundación BBVA
Concluído
2014/04 - 2015/03 Hunger wisdom: ghrelin modulation of adult neurogenesis and its relationship with memory
EXPL/NEU-SCC/1193/2013
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 FCT Fundação para a Ciência e a Tecnologia
2008/01 - 2011/06 Memory loss in Alzheimer’s disease: underlying mechanisms and therapeutic targets (MEMOSAD)
200611
Bolseiro de Pós-Doutoramento
European Commission

Projeto

Designação Financiadores
2022 - 2024 Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis
PTDC/BTM-ORG/0055/2021
Co-Investigador Responsável (Co-IR)
Universidade de Coimbra, Portugal
 FCT Fundação para a Ciência e a Tecnologia
Em curso
2021 - 2024 MicroStress - Regulation of prefrontal cortical synaptic function and behavior by chronic stress-induced microRNA-186-5p
Investigador
Universidade de Coimbra, Portugal
 Obra Social La Caixa
Em curso
2021 - 2023 Postnatal stress, microglia, neuroplasticity and depression: the role of the LPA-LPA1 pathway.
P20_00460
Investigador
Junta de Andalucía Consejería de Transformación Económica Industria Conocimiento y Universidades
Produções

Publicações

Artigo em conferência
  1. Ferreira-Marques, M; Cortes, Luisa; Valero, Jorge; Pereira, Dina; Almeida, Luís Pereira de; Cavadas, Cláudia; Aveleira, Célia A. Autor correspondente: Aveleira, Célia A. "Human Progeria fibroblasts in culture to study new strategies to delay aging". Trabalho apresentado em JRC Summer School on Non-Animal Approaches in Science: The Three R...evolution, 2021.
    Publicado
Artigo em revista
  1. Ferreiro, Elisabete; Monteiro, Mariana; Pereira, Francisco; Barroso, Cristina; Egas, Conceição; Macedo, Paula; Valero, Jorge; Sardão, Vilma A.; Oliveira, Paulo J.. Autor correspondente: Oliveira, Paulo J.. "Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells". Mechanisms of Ageing and Development 218 (2024): 111912. http://dx.doi.org/10.1016/j.mad.2024.111912.
    10.1016/j.mad.2024.111912
  2. Cavaleiro, Carla; Afonso, Gonçalo J. M.; Oliveira, Paulo J.; Valero, Jorge; Mota, Sandra I.; Ferreiro, Elisabete. "Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions". Frontiers in Molecular Neuroscience 16 (2023): http://dx.doi.org/10.3389/fnmol.2023.1229728.
    10.3389/fnmol.2023.1229728
  3. Corraliza-Gomez, Miriam; Bermejo, Teresa; Lilue, Jingtao; Rodriguez-Iglesias, Noelia; Valero, Jorge; Cozar-Castellano, Irene; Arranz, Eduardo; Sanchez, Diego; Ganfornina, Maria Dolores. "Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging". Journal of Neuroinflammation 20 1 (2023): http://dx.doi.org/10.1186/s12974-023-02914-7.
    10.1186/s12974-023-02914-7
  4. Téllez de Meneses, Pablo G.; Pérez-Revuelta, Laura; Canal-Alonso, Ángel; Hernández-Pérez, Carlos; Cocho, Teresa; Valero, Jorge; Weruaga, Eduardo; Díaz, David; Alonso, José R.. "Immunohistochemical distribution of secretagogin in the mouse brain". Frontiers in Neuroanatomy 17 (2023): http://dx.doi.org/10.3389/fnana.2023.1224342.
    10.3389/fnana.2023.1224342
  5. Sol Beccari; Virginia Sierra-Torre; Jorge Valero; Marta Pereira-Iglesias; Mikel García-Zaballa; Federico N. Soria; Laura De Las Heras-Garcia; et al. "Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy". Autophagy (2023): https://doi.org/10.1080/15548627.2023.2165313.
    10.1080/15548627.2023.2165313
  6. Gonçalo J. M. Afonso; Carla Cavaleiro; Jorge Valero; Sandra I. Mota; Elisabete Ferreiro. "Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives". Cells (2023): https://doi.org/10.3390/cells12131763.
    10.3390/cells12131763
  7. David Pérez-Boyero; Carlos Hernández-Pérez; Jorge Valero; Valeria Lorena Cabedo; José Ramón Alonso; David Díaz; Eduardo Weruaga. "The eNOS isoform exhibits increased expression and activation in the main olfactory bulb of nNOS knock-out mice". Frontiers in Cellular Neuroscience 17 (2023): http://dx.doi.org/10.3389/fncel.2023.1120836.
    10.3389/fncel.2023.1120836
  8. Corraliza-Gomez, Miriam; Bendito, Beatriz; Sandonis-Camarero, David; Mondejar-Duran, Jorge; Villa, Miguel; Poncela, Marta; Valero, Jorge; Sanchez, Diego; Ganfornina, Maria D.. "Dual role of Apolipoprotein D as long-term instructive factor and acute signal conditioning microglial secretory and phagocytic responses". Frontiers in Cellular Neuroscience 17 (2023): http://dx.doi.org/10.3389/fncel.2023.1112930.
    10.3389/fncel.2023.1112930
  9. Celia Luchena; Jone Zuazo-Ibarra; Jorge Valero; Carlos Matute; Elena Alberdi; Estibaliz Capetillo-Zarate. "A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer’s Disease". Frontiers in Aging Neuroscience 14 (2022): http://dx.doi.org/10.3389/fnagi.2022.844534.
    10.3389/fnagi.2022.844534
  10. Noelia Rodríguez-Iglesias; Agnes Nadjar; Amanda Sierra; Jorge Valero. "Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia". International Journal of Molecular Sciences 23 6 (2022): 3399-3399. https://doi.org/10.3390/ijms23063399.
    10.3390/ijms23063399
  11. Soraya Martín-Suárez; Jorge Valero; Elena Alberdi; Chris van den Haute; Veerle Baekelandt; Juan Manuel Encinas. "ATP Signaling Triggers a Pro-Neuroinflammatory Program in Hippocampal Neural Stem Cells Characterized by Overexpression of Interleukin-1ß". SSRN Electronic Journal (2022): http://dx.doi.org/10.2139/ssrn.4314960.
    10.2139/ssrn.4314960
  12. Ferreira-Marques, Marisa; Carvalho, André; Franco, Ana Catarina; Leal, Ana; Carmo-Silva, Sara (9D11-2BDFA256); Botelho, Mariana; Cortes, Luísa; et al. "Enhancing ghrelin alleviates aging and extends lifespan of a mouse model of human accelerated aging syndrome (Under Submission)". (2022):
    Submetido
  13. Ribeiro, Filipa F.; Ferreira, Filipa; Rodrigues, Rui S.; Soares, Rita; Pedro, Diogo M.; Duarte-Samartinho, Marta; Aroeira, Rita I.; et al. "Regulation of hippocampal postnatal and adult neurogenesis by adenosine A 2A receptor: Interaction with brain-derived neurotrophic factor". STEM CELLS 39 10 (2021): 1362-1381. http://dx.doi.org/10.1002/stem.3421.
    10.1002/stem.3421
  14. Valero, Jorge. "Mitochondrial SIRT3 confers neuroprotection in Huntington’s disease by regulation of oxidative challenges and mitochondrial dynamics". Free Radical Biology and Medicine (2020): http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.031.
    10.1016/j.freeradbiomed.2020.11.031
  15. Valero, Jorge. "Microglial phagocytosis dysfunction in the dentate gyrus is related to local neuronal activity in a genetic model of epilepsy". Epilepsia 61 11 (2020): 2593-2608. http://dx.doi.org/10.1111/epi.16692.
    10.1111/epi.16692
  16. Ferreiro, Elisabete; Lanzillo, Mariagrazia; Canhoto, Diogo; Carvalho da Silva, António M.; Mota, Sandra I.; Dias, Inês S.; Ferreira, Ildete L.; et al. "Chronic Hyperglycemia Impairs Hippocampal Neurogenesis and Memory in an Alzheimer’s disease mouse model". Neurobiology of Aging (2020): http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.003.
    10.1016/j.neurobiolaging.2020.04.003
  17. Ortiz-Sanz, Carolina; Gaminde-Blasco, Adhara; Valero, Jorge; Bakota, Lidia; Brandt, Roland; Zugaza, José L.; Matute, Carlos; Alberdi, Elena. "Early Effects of Aß Oligomers on Dendritic Spine Dynamics and Arborization in Hippocampal Neurons". Frontiers in Synaptic Neuroscience 12 (2020): http://dx.doi.org/10.3389/fnsyn.2020.00002.
    10.3389/fnsyn.2020.00002
  18. Aveleira, Célia A; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luís; Cavadas, Cláudia. "Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells". The Journals of Gerontology: Series A (2020): http://dx.doi.org/10.1093/gerona/glz280.
    No prelo • 10.1093/gerona/glz280
  19. Diaz-Aparicio, Irune; Paris, Iñaki; Sierra-Torre, Virginia; Plaza-Zabala, Ainhoa; Rodríguez-Iglesias, Noelia; Márquez-Ropero, Mar; Beccari, Sol; et al. "Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome". The Journal of Neuroscience 40 7 (2020): 1453-1482. http://dx.doi.org/10.1523/jneurosci.0993-19.2019.
    10.1523/jneurosci.0993-19.2019
  20. Soraya Martín-Suárez; Jorge Valero; Teresa Muro-García; Juan Manuel Encinas. "Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus". Aging Cell (2019): e12958-e12958. https://doi.org/10.1111/acel.12958.
    10.1111/acel.12958
  21. Quintela-López, Tania; Ortiz-Sanz, Carolina; Serrano-Regal, Mari Paz; Gaminde-Blasco, Adhara; Valero, Jorge; Baleriola, Jimena; Sánchez-Gómez, Maria Victoria; Matute, Carlos; Alberdi, Elena. "Aß oligomers promote oligodendrocyte differentiation and maturation via integrin ß1 and Fyn kinase signaling". Cell Death & Disease 10 6 (2019): http://dx.doi.org/10.1038/s41419-019-1636-8.
    10.1038/s41419-019-1636-8
  22. Rodríguez-Iglesias, Noelia; Sierra, Amanda; Valero, Jorge. "Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia". Frontiers in Cell and Developmental Biology 7 (2019): http://dx.doi.org/10.3389/fcell.2019.00024.
    10.3389/fcell.2019.00024
  23. Naia, Luana; Carmo, Catarina; Campesan, Susanna; Lopes, Carla; Valero, Jorge; Rosenstock, Tatiana R.; Giorgini, Flaviano; Cristina Rego, A.. "SIRT 3 , a modifier of mitochondrial function in Huntington's disease". Free Radical Biology and Medicine 120 (2018): S17. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.072.
    Publicado
  24. Iñaki Paris; Julie C. Savage; Laura Escobar; Oihane Abiega; Steven Gagnon; Chin-Wai Hui; Marie-Ève Tremblay; Amanda Sierra; Jorge Valero. "ProMoIJ: A new tool for automatic three-dimensional analysis of microglial process motility". Glia (2018): https://doi.org/10.1002/glia.23287.
    10.1002/glia.23287
  25. Ferreiro, E.; Pita, I.R.; Mota, S.I.; Valero, J.; Ferreira, N.R.; Fernandes, T.; Calabrese, V.; et al. "Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus". Oncotarget 9 68 (2018): 32929-32942. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052580513&partnerID=MN8TOARS.
    10.18632/oncotarget.25978
  26. Lobo, Jorge. "A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis.". Scientific reports (2017): http://europepmc.org/abstract/med/29184142.
    10.1038/s41598-017-16466-3
  27. Amorim, Rebeca Padrão; Araújo, Michelle Gasparetti Leão; Valero, Jorge; Lopes-Cendes, Iscia; Pascoal, Vinicius Davila Bitencourt; Malva, João Oliveira; da Silva Fernandes, Maria José. "Silencing of P2X7R by RNA interference in the hippocampus can attenuate morphological and behavioral impact of pilocarpine-induced epilepsy". Purinergic Signalling 13 4 (2017): 467-478. http://dx.doi.org/10.1007/s11302-017-9573-4.
    10.1007/s11302-017-9573-4
  28. Valero, J.; Bernardino, L.; Cardoso, F.L.; Silva, A.P.; Fontes-Ribeiro, C.; Ambrósio, A.F.; Malva, J.O.. "Impact of Neuroinflammation on Hippocampal Neurogenesis: Relevance to Aging and Alzheimer's Disease". Journal of Alzheimer's Disease 60 s1 (2017): S161-S168. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029488785&partnerID=MN8TOARS.
    10.3233/JAD-170239
  29. Viana SD; Valero J; Rodrigues-Santos P; Couceiro P; Silva AM; Carvalho F; Ali SF; Fontes-Ribeiro CA; Pereira FC. "Regulation of striatal astrocytic receptor for advanced glycation end-products variants in an early stage of experimental Parkinson's disease.". (2016): http://europepmc.org/abstract/med/27221633.
    10.1111/jnc.13682
  30. Abiega O; Beccari S; Diaz-Aparicio I; Nadjar A; Layé S; Leyrolle Q; Gómez-Nicola D; et al. "Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.". (2016): http://europepmc.org/abstract/med/27228556.
    10.1371/journal.pbio.1002466
  31. Valero J; Paris I; Sierra A. "Lifestyle Shapes the Dialogue between Environment, Microglia, and Adult Neurogenesis.". (2016): http://europepmc.org/abstract/med/26971802.
    10.1021/acschemneuro.6b00009
  32. Matos CA; Nóbrega C; Louros SR; Almeida B; Ferreiro E; Valero J; Pereira de Almeida L; Macedo-Ribeiro S; Carvalho AL. "Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.". (2016): http://europepmc.org/abstract/med/26880203.
    10.1083/jcb.201506025
  33. Rocha SM; Saraiva T; Cristóvão AC; Ferreira R; Santos T; Esteves M; Saraiva C; et al. "Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation.". (2016): http://europepmc.org/abstract/med/27260166.
    10.1186/s12974-016-0600-0
  34. Zussy, C.; Loustalot, F.; Junyent, F.; Gardoni, F.; Bories, C.; Valero, J.; Desarménien, M.G.; et al. "Coxsackievirus adenovirus receptor loss impairs adult neurogenesis, synapse content, and hippocampus plasticity". Journal of Neuroscience 36 37 (2016): 9558-9571. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987796849&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.0132-16.2016
  35. Diez-Hermano, S.; Valero, J.; Rueda, C.; Ganfornina, M.D.; Sanchez, D.. "An automated image analysis method to measure regularity in biological patterns: A case study in a Drosophila neurodegenerative model". Molecular Neurodegeneration (2015): 1-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925674332&partnerID=MN8TOARS.
    10.1186/s13024-015-0005-z
  36. Aveleira, C.A.; Botelho, M.; Carmo-Silva, S.; Pascoal, J.F.; Ferreira-Marques, M.; Nóbrega, C.; Cortes, L.; et al. "Neuropeptide Y stimulates autophagy in hypothalamic neurons". Proceedings of the National Academy of Sciences of the United States of America 112 13 (2015): E1642-E1651. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926180461&partnerID=MN8TOARS.
    10.1073/pnas.1416609112
  37. Mota SI; Ferreira IL; Valero J; Ferreiro E; Carvalho AL; Oliveira CR; Rego AC. "Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway.". (2014): http://europepmc.org/abstract/med/25128699.
    10.1016/j.expneurol.2014.07.023
  38. Curto GG; Nieto-Estévez V; Hurtado-Chong A; Valero J; Gómez C; Alonso JR; Weruaga E; Vicario-Abejón C. "Pax6 is essential for the maintenance and multi-lineage differentiation of neural stem cells, and for neuronal incorporation into the adult olfactory bulb.". (2014): http://europepmc.org/abstract/med/25117830.
    10.1089/scd.2014.0058
  39. Parra-Damas A; Valero J; Chen M; España J; Martín E; Ferrer I; Rodríguez-Alvarez J; Saura CA. "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages.". (2014): http://europepmc.org/abstract/med/24760838.
    10.1523/JNEUROSCI.5288-13.2014
  40. Neiva I; Malva JO; Valero J. "Can we talk about microglia without neurons? A discussion of microglial cell autonomous properties in culture.". (2014): http://europepmc.org/abstract/med/25104923.
    10.3389/fncel.2014.00202
  41. Eiriz MF; Valero J; Malva JO; Bernardino L. "New insights into the role of histamine in subventricular zone-olfactory bulb neurogenesis.". (2014): http://europepmc.org/abstract/med/24982610.
    10.3389/fnins.2014.00142
  42. Valero J; Mastrella G; Neiva I; Sánchez S; Malva JO. "Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory.". (2014): http://europepmc.org/abstract/med/24795557.
    10.3389/fnins.2014.00083
  43. Xapelli, S.; Agasse, F.; Sardà-Arroyo, L.; Bernardino, L.; Santos, T.; Ribeiro, F.F.; Valero, J.; et al. "Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures". PLoS ONE 8 5 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84877955877&partnerID=MN8TOARS.
    10.1371/journal.pone.0063529
  44. Baltanás, F.C.; Berciano, M.T.; Valero, J.; Gómez, C.; Díaz, D.; Alonso, J.R.; Lafarga, M.; Weruaga, E.. "Differential glial activation during the degeneration of Purkinje cells and mitral cells in the PCD mutant mice". GLIA 61 2 (2013): 254-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871293068&partnerID=MN8TOARS.
    10.1002/glia.22431
  45. Fadó, R.; Moubarak, R.S.; Miñano-Molina, A.J.; Barneda-Zahonero, B.; Valero, J.; Saura, C.A.; Moran, J.; Comella, J.X.; Rodríguez-Álvarez, J.. "X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk". Scientific Reports 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883029053&partnerID=MN8TOARS.
    10.1038/srep02397
  46. Malva, J.O.; Xapelli, S.; Baptista, S.; Valero, J.; Agasse, F.; Ferreira, R.; Silva, A.P.. "Multifaces of neuropeptide Y in the brain - Neuroprotection, neurogenesis and neuroinflammation". Neuropeptides 46 6 (2012): 299-308. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869883047&partnerID=MN8TOARS.
    10.1016/j.npep.2012.09.001
  47. Giralt, A.; Puigdellívol, M.; Carretón, O.; Paoletti, P.; Valero, J.; Parra-damas, A.; Saura, C.A.; Alberch, J.; Ginés, S.. "Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity". Human Molecular Genetics 21 6 (2012): 1203-1216. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857674697&partnerID=MN8TOARS.
    10.1093/hmg/ddr552
  48. Gómez, C.; Curto, G.G.; Baltanás, F.C.; Valero, J.; O'Shea, E.; Colado, M.I.; Díaz, D.; Weruaga, E.; Alonso, J.R.. "Changes in the serotonergic system and in brain-derived neurotrophic factor distribution in the main olfactory bulb of pcd mice before and after mitral cell loss". Neuroscience 201 (2012): 20-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855558486&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2011.11.025
  49. Valero, J.; España, J.; Parra-Damas, A.; Martín, E.; Rodríguez-Álvarez, J.; Saura, C.A.. "Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APPSw,Ind transgenic mice". PLoS ONE 6 2 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79951789939&partnerID=MN8TOARS.
    10.1371/journal.pone.0016832
  50. Saura, C.A.; Valero, J.. "The role of CREB signaling in Alzheimer's disease and other cognitive disorders". Reviews in the Neurosciences 22 2 (2011): 153-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954573504&partnerID=MN8TOARS.
    10.1515/RNS.2011.018
  51. España, J.; Valero, J.; Miñano-Molina, A.J.; Masgrau, R.; Martín, E.; Guardia-Laguarta, C.; Lleó, A.; et al. "ß-amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1". Journal of Neuroscience 30 28 (2010): 9402-9410. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954719674&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.2154-10.2010
  52. España, J.; Giménez-Llort, L.; Valero, J.; Miñano, A.; Rábano, A.; Rodriguez-Alvarez, J.; LaFerla, F.M.; Saura, C.A.. "Intraneuronal ß-Amyloid Accumulation in the Amygdala Enhances Fear and Anxiety in Alzheimer's Disease Transgenic Mice". Biological Psychiatry 67 6 (2010): 513-521. http://www.scopus.com/inward/record.url?eid=2-s2.0-76849102559&partnerID=MN8TOARS.
    10.1016/j.biopsych.2009.06.015
  53. Baltanás, F.C.; Weruaga, E.; Valero, J.; Recio, J.S.; Alonso, J.R.. "Albumin attenuates DNA damage in primary-cultured neurons". Neuroscience Letters 450 1 (2009): 23-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-57549085522&partnerID=MN8TOARS.
    10.1016/j.neulet.2008.10.108
  54. Díaz, D.; Valero, J.; Airado, C.; Baltanás, F.C.; Weruaga, E.; Alonso, J.R.. "Sexual dimorphic stages affect both proliferation and serotonergic innervation in the adult rostral migratory stream". Experimental Neurology 216 2 (2009): 357-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-62049085545&partnerID=MN8TOARS.
    10.1016/j.expneurol.2008.12.013
  55. Baltanás, F.C.; Weruaga, E.; Airado, C.; Valero, J.; Recio, J.S.; Díaz, D.; Alonso, J.R.. "Chemical heterogeneity of the periglomerular neurons in the olfactory bulb. A review". European Journal of Anatomy 11 2 (2007): 123-147. http://www.scopus.com/inward/record.url?eid=2-s2.0-35648995868&partnerID=MN8TOARS.
  56. Valero, J.; Weruaga, E.; Murias, A.R.; Recio, J.S.; Curto, G.G.; Gómez, C.; Alonso, J.R.. "Changes in cell migration and survival in the olfactory bulb of the pcd/pcd mouse". Developmental Neurobiology 67 7 (2007): 839-859. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447573986&partnerID=MN8TOARS.
    10.1002/dneu.20352
  57. Recio, J.S.; Weruaga, E.; Gomez, C.; Valero, J.; Briñón, J.G.; Alonso, J.R.. "Changes in the connections of the main olfactory bulb after mitral cell selective neurodegeneration". Journal of Neuroscience Research 85 11 (2007): 2407-2421. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547643024&partnerID=MN8TOARS.
    10.1002/jnr.21387
  58. Porteros, Á.; Gómez, C.; Valero, J.; Calvo-Baltanás, F.; Alonso, J.R.. "Chemical organization of the macaque monkey olfactory bulb: III. Distribution of cholinergic markers". Journal of Comparative Neurology 501 6 (2007): 854-865. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247648138&partnerID=MN8TOARS.
    10.1002/cne.21280
  59. Gómez, C.; Briñón, J.G.; Valero, J.; Recio, J.S.; Murias, A.R.; Curto, G.G.; Orio, L.; Colado, M.I.; Alonso, J.R.. "Sex differences in catechol contents in the olfactory bulb of control and unilaterally deprived rats". European Journal of Neuroscience 25 5 (2007): 1517-1528. http://www.scopus.com/inward/record.url?eid=2-s2.0-34147184733&partnerID=MN8TOARS.
    10.1111/j.1460-9568.2007.05407.x
  60. Valero, J.; Berciano, M.T.; Weruaga, E.; Lafarga, M.; Alonso, J.R.. "Pre-neurodegeneration of mitral cells in the pcd mutant mouse is associated with DNA damage, transcriptional repression, and reorganization of nuclear speckles and Cajal bodies". Molecular and Cellular Neuroscience 33 3 (2006): 283-295. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750619522&partnerID=MN8TOARS.
    10.1016/j.mcn.2006.08.002
  61. Gómez, C.; Briñón, J.G.; Barbado, M.V.; Weruaga, E.; Valero, J.; Alonso, J.R.. "Heterogeneous targeting of centrifugal inputs to the glomerular layer of the main olfactory bulb". Journal of Chemical Neuroanatomy 29 4 (2005): 238-254. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144363077&partnerID=MN8TOARS.
    10.1016/j.jchemneu.2005.01.005
  62. Valero, J.; Weruaga, E.; Murias, A.R.; Recio, J.S.; Alonso, J.R.. "Proliferation markers in the adult rodent brain: Bromodeoxyuridine and proliferating cell nuclear antigen". Brain Research Protocols 15 3 (2005): 127-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-24744469196&partnerID=MN8TOARS.
    10.1016/j.brainresprot.2005.06.001
Capítulo de livro
  1. Valero, Jorge. "Research in the Asperger syndrome neurobiology. Last research results.". 2007.
  2. Lobo, Jorge. "Plasticity in the adult olfactory system". 2006.
  3. Lobo, Jorge. "Immunodetection of BrdU and PCNA in the rostral migratory stream of the adult mouse". Espanha, 2004.
  4. Valero, Jorge. "Stem cell induction.". Espanha, 2002.
Livro
  1. Valero, J.; Eiriz, M.F.; Santos, T.; Neiva, I.; Ferreira, R.; Malva, J.O.. Microglia: The bodyguard and the hunter of the adult neurogenic niche. 2012.
Poster em conferência
  1. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y enhances progerin clearance and delays cellular senescence in human Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em 3rd Molecular Biology of Ageing Meeting, European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, The Netherlands., 2019.
  2. Aveleira, Célia; Ferreira-Marques, Marisa; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y ameliorates the aging phenotype of Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em Ageing: models, mechanisms and therapies Conference, Faculty of Medicine, University of Coimbra, Coimbra, Portugal., 2019.
  3. Rego, Ana Cristina; Ferreiro, Elisabete; Pita IR; Mota, S.I.; Valero, Jorge; Ferreira NR; Fontes-Ribeiro CA; et al. "Enhanced complexity of hippocampal dentate gyrus newly-generated neurons in mice following Coriolus versicolor biomass administration". Trabalho apresentado em FENS 2018, 2018.
  4. Pereira FC; Ferreiro, Elisabete; Pita IR; Mota, S.I.; Valero, Jorge; Ferreira NR; Fontes-Ribeiro CA; et al. "Coriolus Versicolor biomass increases hippocampal dentate gyrus newly-generated neurons complexity in mice". Trabalho apresentado em World Congress of basic and clinical Pharmacology, 2018.
  5. Aveleira, Célia; Botelho, Mariana; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em Cell Symposia – Aging and Metabolism, Sitges, Spain., 2016.
  6. Aveleira, Célia; Cortes, Luísa; Ferreira-Marques, Marisa; Leal, Ana; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Ghrelin enhances progerin clearance and rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome cells.". Trabalho apresentado em 8th Progeria Research Foundation International Scientific Workshop – Across the Table, Around the Globe, Cambridge, MA, USA., 2016.
  7. Naia, Luana; Carmo, Catarina; Oliveira, Ana M; Valero, Jorge; Lopes, Carla; Hayden, Michael R.; Oliveira, C. R.; Rosenstock, Tatiana R.; Rego, Ana Cristina. "Exacerbated SIRT3 activity alters mitochondrial function and dynamics in Huntington’s disease models.". Trabalho apresentado em Society for Neuroscience 46th Annual Meeting, 2016.
  8. Botelho, Mariana; Aveleira, Célia; Carmo-Silva, Sara; Pascoal, Jorge; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luísa; et al. "Autophagy in the hypothalamus: the role of Neuropeptide Y.". Trabalho apresentado em 9th IBRO World Congress on Neuroscience, Rio de Janeiro, Brazil., 2015.
  9. Aveleira, Célia; Cortes, Luísa; Valero, Jorge; Pereira, Dina; Pereira de Almeida, Luis Fernando Morgado; Cavadas, Claudia. "Neuropeptide Y enhances progerin clearance and rescues the senescent phenotype of human Hutchinson-Gilford Progeria Syndrome fibroblasts.". Trabalho apresentado em The Translational Science of Aging: From Functional Pathways to Interventions Gordon Research Conference on Biology of Aging, Sunday River, Newry, USA., 2015.
  10. Ferreiro, Elisabete; Lanzillo M; Silva A.M.; Mastrella, G; Mota, S.I.; Fontes, A.R.; Ferreira, I.L.; et al. "Effect of chronic hyperglycemia on newly-generated neurons maturation and memory in a transgenic mouse model of Alzheimer’s disease.". Trabalho apresentado em XIV Meeting of the Portuguese Society for Neuroscience, 2015.
  11. Ferreiro, Elisabete; Lanzillo M; Silva, A.M.; Mastrella, G; Mota, S.I.; Fontes, A.R; Ferreira, I.L.; et al. "Linking impairment of hippocampal neurogenesis and memory loss in a diabetic-like Alzheimer’s disease mouse model.". Trabalho apresentado em Adult Neurogenesis: Evolution, Regulation and Function, 2015.
  12. Viana SD; Valero, Jorge; Rodrigues-Santos, Paulo; Couceiro, Patrícia; Silva, Andréa M.; Carvalho, Félix; Ali, Syed F.; Fontes Ribeiro, C.A.; Pereira, F.C.. "EnRAGEd pre-gliotic striatal astrocytes in MPTP mice". Trabalho apresentado em VII Annual Meeting of IBILI “New trends in biomedical research”, 2015.
  13. Carmo, Catarina; Naia, Luana; Oliveira, Ana M; Valero, Jorge; Rosenstock, Tatiana R.; Rego, Ana Cristina. "Sirtuin 3 overexpression affects mitochondrial dynamics in striatal cells derived from Huntington’s disease knock-in mice". Trabalho apresentado em XIV Meeting of the Portuguese Society for Neurosciences, 2015.
  14. Carmo, Catarina; Naia, Luana; Oliveira, Ana M.; Valero, Jorge; Rosenstock, Tatiana R.; Rego, Ana Cristina. "Altered mitochondrial function and dynamics imposed by sirtuin 3 overexpression in Huntington’s disease striatal cells". Trabalho apresentado em XXXIX Portuguese Genetics Conference, 2015.
  15. Ferreiro, Elisabete; Lanzillo M; Silva, A.M.; Mastrella, G.; Mota, S.I.; Fontes, A.R.; Ferreira, I.L.; et al. "Impaired memory in a transgenic mouse model of Alzheimer’s disease under hyperglycemia – a link to reduced hippocampal neurogenesis?". Trabalho apresentado em XII CNC Annual Meeting, 2014.
Pré-impressão
  1. Jorge Valero; Elisabete Ferreiro; Noelia Rodríguez-Iglesias; João Cardoso. "A new method and tool for volumetric estimation of brain structures after serial sectioning". 2022. http://dx.doi.org/10.1101/2022.03.18.484850.
    10.1101/2022.03.18.484850
Resumo em conferência
  1. Botelho, Mariana; Aveleira, Célia; Carmo-Silva, Sara; Pascoal, Jorge; Ferreira-Marques, Marisa; Nóbrega, Clévio; Cortes, Luisa; et al. "Neuropeptide Y1 and Y5 receptors activation stimulate autophagic flux in mouse hypothalamic neurons". Trabalho apresentado em Advances on NPY. Proceedings published in Neuropeptides, 2016.
    Publicado

Outros

Outra produção
  1. Microglial phagocytosis dysfunction during stroke is prevented by rapamycin. 2021. S Beccari; V Sierra-Torre; J Valero; M García-Zaballa; A Carretero-Guillen; E Capetillo-Zarate; M Domercq; et al. https://doi.org/10.1101/2021.11.12.468358.
    10.1101/2021.11.12.468358
  2. ProMoIJ. ProMoIJ (Process Motility in ImageJ) is a pack of ImageJ macros to perform semi-automatic motility analysis of microglial processes in 3D from 2-photon time-lapse experiments. It can also be adapted to analyze motility of non-hollow and non-twisted tubular structures such as cellular filaments, dendrites, dendritic spines, growth cone filopodia, cilia, plant roots, and growing stalactites.. 2019. Valero, Jorge. https://www.achucarro.org/es/downloads.
  3. CellShaper. CellShaper is a pack of ImageJ macros developed to analyze the morphology of hippocampal stem cells.. 2019. Valero, Jorge. https://www.achucarro.org/es/downloads.
  4. FLEYE. FLEYE is a package of ImageJ macros developed to classify fly eyes attending to the distribution of their ommatidia using images of the eye surface as starting data. 2015. Valero, Jorge. https://imagejdocu.tudor.lu/plugin/analysis/fleye/start.
  5. Nuclear Signs of Pre-neurodegeneration. 2014. Fernando C. Baltanás; Jorge Valero; Jose Ramón Alonso; Maria Teresa Berciano; Miguel Lafarga; Baltanás, F.C.; Valero, J.; et al. http://dx.doi.org/10.1007/978-1-4939-2152-2_4.
    10.1007/978-1-4939-2152-2_4
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/10 Influence of lifestyle on the hippocampal reserve and memory: environmental stimulation effects on mice Jornada Científica del Instituto de Neurociencias de Castilla y León
Instituto de Neurociencias de Castilla y León (Salamanca, Espanha)
2023/09 Quantitative Imaging II: Image Analysis Hands-On Workshop Quantitatitve Imaging Workshop
IBRO (Granada, Espanha)
2022/10/14 Incorporatiion of bone marrow cells to the cerebellum Jornada Científica del Instituto de Neurociencias de Castilla y León
(Salamanca, Espanha)
2022 Incorporation of new cells into the mouse adult brain: from behavior to microscopy 2nd Capacity Building Workshop.
Brain Twin
2022 Tools for image analysis 2nd Capacity Building Workshop.
Brain Twin
2020 Phagocytic microglia actively regulates adult hippocampal neurogenesis 11th NEURONUS 2020 IBRO Neuroscience Forum
Neuronus 2020 IBRO Neuroscience Forum (Leioa, Espanha)
2019 Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus Spanish & Portuguese Advanced Optical Microscopy 2019
(Coimbra, Portugal)
2019 Semi-automated analysis of microglial processes motility XIV European Meeting on Glial Cells in Health and Disease
(Porto, Portugal)
2019 Microglia actively remodels adult hippocampal Neurogenesis through the phagocytosis secretome Eurogenesis Meeting 2019
(Bourdeaux, França)
2019 Microglia actively remodels adult hippocampal neurogenesis through the phagocytosis secretome 2nd RENA SYMPOSIUM
(Valencia, Espanha)
2017 Life factors shape adult neurogenesis and hippocampal dependent memory in animal models of Alzheimer's Disease Mediterranean Neuroscience Society 6th Conference TIPO
(Malta, Malta)
2017 The hippocampal niche turns neuro/astrogenic in mature mice 1st Annual RENA Symposium
(Bilbao, Espanha)
2016 Automatic analysis of microglial motility with ImageJ SPAOM 2016
(Bilbao, Espanha)
2016 Microglial phagocytosis efficiency determines the dynamics of newborn cell apoptosis in the neurogenic niche Eurogenesis Meeting 2016
(Bourdeaux, França)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - Atual Study of the integration of different populations of bone marrow-derived cells in the central nervous system
Coorientador
 Neurosciences (Doutoramento)
Universidad de Salamanca, Espanha
2020 - Atual Regulación microglial de la integración de las nuevas neuronas en el circuito hipocampal
Coorientador
 Neurociencias (Doutoramento)
Universidad del País Vasco, Espanha
2020 - Atual Unconventional neurogenic niches and where to find them: from postnatal to aging
Coorientador
Universidade de Lisboa, Portugal
2019 - 2022/10/26 Microglia: development of a human in vitro model, analysis of motility and effects of phagocytosis in the hippocampal neurogenic niche.
Coorientador
 Neurociencias (Doutoramento)
Universidad del País Vasco, Espanha
2021 - 2022 Differentiation of bone marrow-derived cells in cerebellar organotypic slices
Coorientador
 Neuroscience (Mestrado)
Institute for Neuroscience of Castilla y León, Espanha
2021 - 2022 Study about the integrity of the blood-brain barrier during a selective neuronal death process
Coorientador
 Neuroscience (Mestrado)
Instituto de Neurociencias de Castilla y León, Espanha
2020 - 2021 Eficacia de la rehabilitación por ordenador de dos personas con daño cerebral adquirido
Orientador
Universidad Europea del Atlántico, Espanha
2020 - 2021 Inteligencia emocional y resiliencia ante la COVID-19
Orientador
Universidad Europea del Atlántico, Espanha
2020 - 2020 Neuroatomical characterization of cerebellar Purkinje cells in a mouse model of autism
Coorientador
Universidad del País Vasco, Espanha
2018 - 2018 Microglial phagocytosis of apoptotic cells triggers a neuromodulatory program that supports neurogenesis
Coorientador
 Neurosciences (Doutoramento)
Universidad del País Vasco, Espanha
2018 - 2018 Efectos de los ácidos grasos omega-3 y omega-6 sobre la neurogénesis adulta ante un evento inflamatorio
Orientador
 Neurociencias (Mestrado)
Universidad del País Vasco, Espanha

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/07/10 - 2019/07/10 Workshop in the XIV European Glial Meeting: Imaging glial cells: image analysis tools to optimize data collection (2019/07/10)
Oficina (workshop) (Coorganizador)
 European Glial Meeting, Alemanha
2013/05/30 - 2013/06/01 Co-organizer of the XIII Meeting of the Portuguese Society for Neurosciences (2013/05/30 - 2013/06/01)
Congresso (Coorganizador)
 Portuguese Society for Neuroscience, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2023/09 - Atual Speed Neurodating
Mesa-redonda
 Speed Neurodating special interest event
Ad Libros Publications Inc, Estados Unidos

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2013 - Atual Frontiers in Neuroscience
2013 - Atual Frontiers in Cellular Neuroscience

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2018 - 2022 Evaluation of research project applications
Especialista
 Gobierno de España Agencia Estatal de Investigación, Espanha Gobierno de España Agencia Estatal de Investigación
2019 - 2019 Evaluation of research projects applications
Especialista
 The French National Research Agency, França The French National Research Agency
2018 - 2019 Evaluation of research fellowships proposals
Especialista
 The Graduate Women in Science, Estados Unidos The Graduate Women in Science

Entrevista / Programa (rádio / tv)

Programa Tema
2024 - Atual Ojo con tu salud. Amiotrophyc lateral sclerosis

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2022 - Atual Zoologycal Research
2021 - Atual Journal of Pharmacy and Pharmacology
2020 - Atual International Journal of Developmental Neuroscience
2020 - Atual Current Neuropharmacology
2020 - Atual Neuroimmunology and Neuroinflammation
2020 - Atual Journal of Cellular Physiology
2020 - Atual Revista Mexicana de Psicología
2019 - Atual Frontiers in Pharmacology (1663-9812) Frontiers Media SA
2019 - Atual Frontiers in Cell and Developmental Biology (2296-634X) Frontiers Media SA
2019 - Atual Journal of Visualized Experiments (1940-087X) MyJoVE Corporation
2018 - Atual Frontiers in Behavioral Neuroscience
2018 - Atual Journal of Neuroinflammation (1742-2094) Springer (Biomed Central Ltd.)
2017 - Atual Frontiers in Molecular Neuroscience
2017 - Atual Frontiers in Aging Neuroscience
2017 - Atual CNS & Neurological Disorders - Drug Targets (1871-5273) Bentham Science
2017 - Atual The Anatomical Record (1097-0185) Wiley (John Wiley & Sons)
2016 - Atual Brain Behavior and Immunity
2016 - Atual Journal of Neuroscience Research (1097-4547) Wiley (John Wiley & Sons)
2014 - Atual Neurobiology of Learning and Memory (1095-9564) Elsevier
Distinções

Prémio

2008 Doctorate extraordinary prize from Universidad de Salamanca.
Universidad de Salamanca, Espanha

Outra distinção

2021 i3 Certificate
Ministerio de Ciencia, Innovación y Universidades., Espanha