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Identificação

Identificação pessoal

Nome completo
Martin Vojtek

Nomes de citação

  • Vojtek, Martin

Identificadores de autor

Ciência ID
5F15-7817-94DC
ORCID iD
0000-0002-9257-7020
Google Scholar ID
4EGxlX0AAAAJ
Researcher Id
AAG-4903-2019

Moradas

  • Faculty of Pharmacy - University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Porto, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Médicas e da Saúde - Ciências da Saúde
Produções

Publicações

Artigo em conferência
  1. Ana Cerquido; Martin Vojtek; Olga Viegas; Patricia Dias-Pereira; Carmen Diniz. "Adenosine Overcomes Triple-Negative Breast Cancer Resistance to Platinum-Derived Chemotherapeutic Drugs". 2022.
    10.3390/ECMC2022-13458
  2. Martin Vojtek; Maria P. M. Marques; Ana L. M. Batista de Carvalho; Helder Mota-Filipe; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Palladium-Spermine Complex (Pd2Spm) Triggers Autophagy and Caspase-Independent Cell Death in Triple-Negative Breast Cancer Cells". 2022.
    10.3390/ECMC2022-13469
Artigo em revista
  1. Monika Majirská; Martina Bago Pilátová; Zuzana Kudlicková; Martin Vojtek; Carmen Diniz. "Targeting hematological malignancies with isoxazole derivatives". Drug Discovery Today 29 (2024): 104059.
    Acesso aberto • Publicado • 10.1016/j.drudis.2024.104059
  2. Tatiana J. Carneiro; Ana L. M. Batista de Carvalho; Martin Vojtek; Raquel C. Laginha; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer". Journal of Medicinal Chemistry 67 (2024): 6839-6853.
    Acesso aberto • 10.1021/acs.jmedchem.4c00435
  3. Carneiro, Tatiana J.; Carvalho, Ana L. M. Batista; Vojtek, Martin; Carmo, Inês F.; Marques, Maria Paula M.; Diniz, Carmen; Gil, Ana M.. "Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics". Cancer Cell International 23 1 (2023): http://dx.doi.org/10.1186/s12935-023-03124-0.
    10.1186/s12935-023-03124-0
  4. Martin Vojtek; Clara B. Martins; Raquel Ramos; Sara Gomes Duarte; Isabel M. P. L. V. O. Ferreira; Ana L. M. Batista de Carvalho; M. Paula M. Marques; Carmen Diniz. "Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041205.
    10.3390/pharmaceutics15041205
  5. Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232213773.
    10.3390/ijms232213773
  6. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Olga Viegas; Joana Beatriz Sousa; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Unravelling Potential Health-Beneficial Properties of Corema album Phenolic Compounds: A Systematic Review". Pharmaceuticals (2022): https://doi.org/10.3390/ph15101231.
    10.3390/ph15101231
  7. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Salomé Gonçalves-Monteiro; Maria João Barroca; Aida Moreira da Silva; Olga Viegas; et al. "Corema album Leaves Mediate DNA Damage in Triple-Negative Breast Cancer Cells". Current Issues in Molecular Biology (2022): https://doi.org/10.3390/cimb44080246.
    10.3390/cimb44080246
  8. Tatiana J. Carneiro; Martin Vojtek; Salomé Gonçalves-Monteiro; João R. Neves; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14020259.
    10.3390/pharmaceutics14020259
  9. Martin Vojtek; Salomé Gonçalves-Monteiro; Patrícia Seminská; Katarína Valová; Loreto Bellón; Patrícia Dias-Pereira; Franklim Marques; et al. "Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of Triple-Negative Breast Tumors in Mice". Biomedicines (2022): https://doi.org/10.3390/biomedicines10020210.
    10.3390/biomedicines10020210
  10. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Ana L. M. Batista de Carvalho; Maria Paula M. Marques; Carmen Diniz; Ana M. Gil. "Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model". International Journal of Molecular Sciences 22 19 (2021): 10775-10775. https://doi.org/10.3390/ijms221910775.
    10.3390/ijms221910775
  11. Salomé Gonçalves-Monteiro; Rita Ribeiro-Oliveira; Maria Sofia Vieira-Rocha; Martin Vojtek; Joana B. Sousa; Carmen Diniz. "Insights into Nuclear G-Protein-Coupled Receptors as Therapeutic Targets in Non-Communicable Diseases". Pharmaceuticals 14 5 (2021): 439-439. https://doi.org/10.3390/ph14050439.
    10.3390/ph14050439
  12. Martin Vojtek; Salomé Gonçalves-Monteiro; Edgar Pinto; Sára Kalivodová; Agostinho Almeida; Maria P. M. Marques; Ana L. M. Batista de Carvalho; et al. "Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in Mice". Pharmaceuticals 14 2 (2021): 173-173. https://doi.org/10.3390/ph14020173.
    10.3390/ph14020173
  13. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Carmen Diniz; Ana L. M. Batista de Carvalho; M. Paula M. Marques; Ana M. Gil. "Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent". Metabolites 11 2 (2021): 114-114. https://doi.org/10.3390/metabo11020114.
    10.3390/metabo11020114
  14. Martin Vojtek; Edgar Pinto; Salomé Gonçalves-Monteiro; Agostinho Almeida; M. P. M. Marques; Helder Mota-Filipe; Isabel M. P. L. V. O. Ferreira; Carmen Diniz. "Fast and reliable ICP-MS quantification of palladium and platinum-based drugs in animal pharmacokinetic and biodistribution studies". Analytical Methods (2020): https://doi.org/10.1039/D0AY01328E.
    10.1039/D0AY01328E
  15. Tatiana J. Carneiro; Rita Araújo; Martin Vojtek; Salomé Gonçalves-Monteiro; Carmen Diniz; Ana L.M. Batista de Carvalho; Maria Paula M. Marques; Ana M. Gil. "Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisplatin in Mice". Metabolites 9 11 (2019): 279-279. https://doi.org/10.3390/metabo9110279.
    10.3390/metabo9110279
  16. Rita Ribeiro-Oliveira; Martin Vojtek; Salomé Gonçalves-Monteiro; Maria Sofia Vieira-Rocha; Joana B. Sousa; Jorge Gonçalves; Carmen Diniz. "Nuclear G-protein-coupled receptors as putative novel pharmacological targets". Drug Discovery Today (2019): https://doi.org/10.1016/j.drudis.2019.09.003.
    10.1016/j.drudis.2019.09.003
  17. Ana Sousa-Oliveira; Ana Brandão; Martin Vojtek; Salomé Gonçalves-Monteiro; Joana B. Sousa; Carmen Diniz. "Vascular impairment of adenosinergic system in hypertension: increased adenosine bioavailability and differential distribution of adenosine receptors and nucleoside transporters". Histochemistry and Cell Biology 151 5 (2019): 407-418. https://doi.org/10.1007/s00418-018-1743-0.
    10.1007/s00418-018-1743-0
  18. Olga Viegas; Miguel A. Faria; Joana B. Sousa; Martin Vojtek; Salomé Gonçalves-Monteiro; Joanna Suliburska; Carmen Diniz; Isabel M.P.L.V.O. Ferreira. "Delphinidin-3-O-glucoside inhibits angiogenesis via VEGFR2 downregulation and migration through actin disruption". Journal of Functional Foods 54 (2019): 393-402. https://doi.org/10.1016%2Fj.jff.2019.01.039.
    10.1016/j.jff.2019.01.039
  19. Vojtek M; Marques MPM; Ferreira IMPLVO; Mota-Filipe H; Diniz C. "Anticancer activity of palladium-based complexes against triple-negative breast cancer.". Drug discovery today (2019): http://europepmc.org/abstract/med/30849441.
    10.1016/j.drudis.2019.02.012
  20. Laranjeira P; Duque M; Vojtek M; Inácio MJ; Silva I; Mamede AC; Laranjo M; et al. "Amniotic membrane extract differentially regulates human peripheral blood T cell subsets, monocyte subpopulations and myeloid dendritic cells.". Cell and tissue research (2018): http://europepmc.org/abstract/med/29582167.
    10.1007/s00441-018-2822-1
Poster em conferência
  1. Martin Vojtek; A.L.M. Batista de Carvalho, M.P.M. Marques, Helder Mota-Filipe, Isabel M.P.L.V.O Ferreira, Carmen Diniz. "Palladium-spermine complex (Pd2Spm) triggers autophagy and caspase-independent cell death in triple-negative breast cancer cells. (PRESENTER)". Trabalho apresentado em The 8th International Electronic Conference on Medicinal Chemistry (ECMC 2022), Online, 2022.
  2. Carneiro, TJ; Vojtek, M; Gonçalves-Monteiro, S; Batista de Carvalho, ALM; Marques, MPM; Diniz, C; Gil, AM.. "In vivo 1H NMR metabolomics: Triple-Negative Breast Cancer response to anticancer drug Pd2(Spermine).". Trabalho apresentado em 8th International Iberic Biophysics Congress, 2022.
  3. Vojtek, Martin; Salomé Gonçalves-Monteiro, Edgar Pinto, Patrícia Dias-Pereira, Franklim Marques, A.L.M. Batista de Carvalho, M.P.M. Marq. "Anticancer activity of palladium-spermine complex against triple-negative breast cancer (PRESENTER)". Trabalho apresentado em 8th European Virtual Congress of Pharmacology (EPHAR2021), 2021.
  4. Carneiro, TJ; Araújo, R; Vojtek, M; Gonçalves-Monteiro, S; Diniz, C; Batista de Carvalho, ALM; Marques, MPM; Gil, AM.. "NMR metabolic profile of the in vivo impact of a potential anticancer drug -Pd(2)spermine.". Trabalho apresentado em EUROMAR 2021, 2021.
  5. Carneiro, TJ; Araújo, R; Vojtek, M; Gonçalves-Monteiro, S; Diniz, C; Batista de Carvalho, ALM; Marques, MPM; Gil, AM.. "NMR metabolomics to assess the impact of anticancer drugs cisplatin and Pd(2)spermine on mice organs.". Trabalho apresentado em 9th Iberoamerican NMR Meeting, 2021.
  6. Carneiro, TJ; Araújo, R; Vojtek, M; Monteiro, S; Batista de Carvalho, ALM; Pereira, C; Marques, MPM; Gil, AM.. "Nuclear magnetic resonance metabolomics to evaluate the metabolic impact of cisplatin and a potential new anti-cancer drug - Palladium(II)-spermine - In a mouse model.". Trabalho apresentado em III International Congress in Health Sciences Research, 2019.
  7. Carneiro, TJ; Araújo, R; Vojtek, M; Monteiro, S; Batista de Carvalho, ALM; Pereira, C; Marques, MPM; Gil, AM.. "NMR metabolomics to assess nephrotoxicity induced by cisplatin and Pd2(spermine) in a mouse model". Trabalho apresentado em Jornadas CICECO 2019, 2019.
  8. Vojtek, Martin; Inês Lamego, Edgar Pinto, Agostinho A. Almeida, Isabel M.P.L.V.O. Ferreira, Ana L.M. Batista de Carvalho, M.P.M. Marques. "Anticancer Metal-Polyamine Complexes Against Breast Cancer. (PRESENTER)". Trabalho apresentado em 11th Meeting of Young Researchers – University of Porto, 2018.
Relatório
  1. Ana Sofia Cerquido; Martin Vojtek; Rita Ribeiro-Oliveira; Olga Viegas; Joana Beatriz Sousa; Isabel M.P.L.V.O. Ferreira; Carmen Diniz. 2022. Unravelling potential health-beneficial properties of Corema album phenolic compounds: a systematic review. https://doi.org/10.37766/inplasy2022.8.0022.
    10.37766/inplasy2022.8.0022
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/10 Development of Palladium-spermine complex (Pd2Spm) for triple-negative breast cancer cells – in vitro and in vivo X Congresso Iberoamericano de Ciências Farmacêuticas
FFUC (Coimbra, Portugal)
2020/02 Anticancer palladium-spermine complex: in vivo activity against triple-negative breast cancer in mice SPF 2020 – Reunião Anual daSociedade Portuguesa de Farmacologia
Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/02 Novel cost-effective ICP-MS method for pharmaco-toxicokinetic studies ofplatinum and palladium-based drugs in animal tissues XLIX Reunião Anual da SociedadePortuguesa de Farmacologia, XXXVII Reunião de Farmacologia Clínica e XVII Reunião de Toxicologia
Sociedade Portuguesa Farmacologia (Porto, Portugal)
2018/02 Anticancer Metal Complexes with Polyamines Against Breast Cancer: Cellular Drug Uptake and Selective Cytotoxicity XLVIII Annual Meeting of Portuguese Pharmacological Society, XXXVI Clinical Pharmacology, XVII Toxicology
(Lisbon, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/02 - Atual Unlocking Triple-Negative Breast Cancer resistance in 3D models
Orientador de Beatriz M.
 Bioquímica
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/02/01 - 2022/07/01 Impact of the Nucleoside Adenosine in Triple-Negative Breast Cancer
Coorientador de Andreia S.
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/01/01 - 2021/07/25 Strategies to Combat the Resistance of Breast Cancer Cells - Combination of Platinum(II)-based Drugs with Adenosine
Orientador de Sara D.
 Biotecnologia Medicinal (Licenciatura/Bacharelato)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2021/01/01 - 2021/07/25 Anticancer Activity of Novel Trinuclear Platinum(II)- and Palladium(II)-based Complexes with Spermidine against Breast Cancer
Coorientador de Raquel R.
 Biotecnologia Medicinal (Licenciatura/Bacharelato)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2020/01/01 - 2020/07/30 Antioxidant and Anti-inflammatory Activities Exerted by Phenolic Compounds Extracted from Corema album Leaves
Orientador de Ana S. C.
 Bachelor degree in Biochemistry (Licenciatura/Bacharelato)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/02/06 - 2019/02/08 XLIX Reunião Anual da SociedadePortuguesa de Farmacologia, XXXVIIReunião de Farmacologia Clínica e XVIIReunião de Toxicologia (2019/02/06 - 2019/02/08)
Congresso (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Farmácia, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2021/11/15 - 2021/12/03 Training programme in design thinking, startup, customer service delivery and innovative project. Total duration of 30 hours (online).
Seminário
 Doctor'Preneuriales training programme
Université Paris-Saclay, França

Membro de associação

Nome da associação Tipo de participação
2019 - Atual Portuguese Society of Pharmacology Member

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2020/12/01 - Atual Cancers MDPI
2020/12/01 - Atual Molecules MDPI
2020/12/01 - Atual Future Pharmacology MDPI
2020/12/01 - Atual International Journal of Molecular Sciences MDPI
2020/12/01 - Atual Cardiovascular Toxicology Springer Nature
2020/12/01 - Atual Brazilian Journal of Pharmaceutical Sciences University of Sao Paolo

Tutoria

Tópico Nome do aluno
2023/09 - 2024/02 Supervision of Scientific Mobility Internship - PhD student Monika M.
2020/09 - 2020/12 Scientific internship of recent graduates in Pharmacy (Erasmus+) Annamária L.
2020/06 - 2020/12 Scientific internship of recent graduates in Pharmacy (Erasmus+) Monika M.
2019/10 - 2020/05 Scientific internship of recent graduates in Pharmacy (Erasmus+) Sara K.
2019/07 - 2019/09 Scientific internship of recent graduates in Pharmacy (Erasmus+) Maria D.
2019/07 - 2019/09 Scientific internship of recent graduates in Pharmacy (Erasmus+) Zuzana K.
2019/01 - 2019/08 Scientific internship of recent graduates in Pharmacy (Erasmus+) Katarína V.
2019/01 - 2019/07 Scientific internship of Pharmacy students (Erasmus+) Patrícia S.
2018/05 - 2018/08 Scientific internship of recent graduates in Pharmacy (Erasmus+) Andrea S.