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Przemyslaw Sitarek. Published 42 articles in journals. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Saccharin; Tetrazole; 1, 3, 4-thiadiazole; H7PX glioma cells; Antimicrobial screening; Antioxidant capacity; .
Identificação

Identificação pessoal

Nome completo
Przemyslaw Sitarek

Nomes de citação

  • Sitarek, Przemyslaw

Identificadores de autor

Ciência ID
6116-2E53-3AD5
ORCID iD
0000-0001-5495-3550

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês
Formação
Grau Classificação
2009/10/01 - 2012/02/24
Concluído
Medical University of Lodz (Doctor)
Uniwersytet Medyczny w Lodzi, Polónia
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2013/04/02 - Atual Investigador (Investigação) Uniwersytet Medyczny w Lodzi, Polónia
Projetos

Outro

Designação Financiadores
2015/06/01 - 2017/10/01 Leonurus sibiricus L. as a potential sourse of secondary metabolites and its biological properties.
Outra
Concluído
Produções

Publicações

Artigo em revista
  1. Ceremuga, M.; Stela, M.; Janik, E.; Gorniak, L.; Synowiec, E.; Sliwinski, T.; Sitarek, P.; Saluk-Bijak, J.; Bijak, M.. "Melittin—a natural peptide from bee venom which induces apoptosis in human leukaemia cells". Biomolecules 10 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079214653&partnerID=MN8TOARS.
    10.3390/biom10020247
  2. Lojewska, E.; Sakowicz, T.; Kowalczyk, A.; Konieczka, M.; Grzegorczyk, J.; Sitarek, P.; Skala, E.; et al. "Production of recombinant colicin M in Nicotiana tabacum plants and its antimicrobial activity". Plant Biotechnology Reports 14 1 (2020): 33-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074476559&partnerID=MN8TOARS.
    10.1007/s11816-019-00571-y
  3. Kowalczyk, T.; Sitarek, P.; Toma, M.; Picot, L.; Wielanek, M.; Skala, E.; Sliwinski, T.. "An extract of transgenic senna obtusifolia L. Hairy roots with overexpression of PgSS1 gene in combination with chemotherapeutic agent induces apoptosis in the leukemia cell line". Biomolecules 10 4 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85082731684&partnerID=MN8TOARS.
    10.3390/biom10040510
  4. Kowalczyk, T.; Wieczfinska, J.; Skala, E.; Sliwinski, T.; Sitarek, P.. "Transgenesis as a tool for the efficient production of selected secondary metabolites from in vitro plant cultures". Plants 9 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078782765&partnerID=MN8TOARS.
    10.3390/plants9020132
  5. Merecz-Sadowska, A.; Sitarek, P.; Zielinska-Blizniewska, H.; Malinowska, K.; Zajdel, K.; Zakonnik, L.; Zajdel, R.. "A summary of in vitro and in vivo studies evaluating the impact of E-Cigarette exposure on living organisms and the environment". International Journal of Molecular Sciences 21 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078221376&partnerID=MN8TOARS.
    10.3390/ijms21020652
  6. Wieczfinska, J.; Sitarek, P.; Skala, E.; Kowalczyk, T.; Pawliczak, R.. "Correction to: Inhibition of NADPH Oxidase-Derived Reactive Oxygen Species Decreases Expression of Inflammatory Cytokines in A549 Cells (Inflammation, (2019), 42, 6, (2205-2214), 10.1007/s10753-019-01084-0)". Inflammation (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079438730&partnerID=MN8TOARS.
    10.1007/s10753-020-01196-y
  7. Sitarek, P.; Toma, M.; Ntungwe, E.; Kowalczyk, T.; Skala, E.; Wieczfinska, J.; Sliwinski, T.; Rijo, P.. "Insight the biological activities of selected abietane diterpenes isolated from plectranthus spp.". Biomolecules 10 2 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078786645&partnerID=MN8TOARS.
    10.3390/biom10020194
  8. Wieczfinska, J.; Sitarek, P.; Skala, E.; Kowalczyk, T.; Pawliczak, R.. "Inhibition of NADPH Oxidase-Derived Reactive Oxygen Species Decreases Expression of Inflammatory Cytokines in A549 Cells". Inflammation 42 6 (2019): 2205-2214. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074046583&partnerID=MN8TOARS.
    10.1007/s10753-019-01084-0
  9. Kowalczyk, T.; Sitarek, P.; Skala, E.; Toma, M.; Wielanek, M.; Pytel, D.; Wieczfinska, J.; Szemraj, J.; Sliwinski, T.. "Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells". Cytotechnology 71 1 (2019): 165-180. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059562770&partnerID=MN8TOARS.
    10.1007/s10616-018-0274-9
  10. Kowalczyk, T.; Sitarek, P.; Skala, E.; Rijo, P.; Andrade, J.M.; Synowiec, E.; Szemraj, J.; Krajewska, U.; Sliwinski, T.. "An Evaluation of the DNA-Protective Effects of Extracts from Menyanthes trifoliata L. Plants Derived from In Vitro Culture Associated with Redox Balance and Other Biological Activities". Oxidative Medicine and Cellular Longevity 2019 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074349145&partnerID=MN8TOARS.
    10.1155/2019/9165784
  11. Skala, E.; Picot, L.; Bijak, M.; Saluk-Bijak, J.; Szemraj, J.; Kicel, A.; Olszewska, M.A.; Sitarek, P.. "An efficient plant regeneration from Rhaponticum carthamoides transformed roots, enhanced caffeoylquinic acid derivatives production in pRi-transformed plants and their biological activity". Industrial Crops and Products 129 (2019): 327-338. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058146630&partnerID=MN8TOARS.
    10.1016/j.indcrop.2018.12.020
  12. Frija, L.M.T.; Ntungwe, E.; Sitarek, P.; Andrade, J.M.; Toma, M.; Sliwinski, T.; Cabral, L.; et al. "In vitro assessment of antimicrobial, antioxidant, and cytotoxic properties of saccharin–tetrazolyl and –thiadiazolyl derivatives: The simple dependence of the ph value on antimicrobial activity". Pharmaceuticals 12 4 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075070337&partnerID=MN8TOARS.
    10.3390/ph12040167
  13. Zielinska-Blizniewska, H.; Sitarek, P.; Merecz-Sadowska, A.; Malinowska, K.; Zajdel, K.; Jablonska, M.; Sliwinski, T.; Zajdel, R.. "Plant extracts and reactive oxygen species as two counteracting agents with anti- and pro-obesity properties". International Journal of Molecular Sciences 20 18 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072513221&partnerID=MN8TOARS.
    10.3390/ijms20184556
  14. Frija, Luís M. T.; Ntungwe, Epole; Sitarek, Przemyslaw; Andrade, Joana M.; Toma, Monika; Sliwinski, Tomasz; Cabral, Lília; et al. "In vitro assessment of antimicrobial, antioxidant, and cytotoxic properties of Saccharin-Tetrazolyl and-Thiadiazolyl derivatives: the simple dependence of the pH value on antimicrobial activity". (2019): http://hdl.handle.net/10400.1/13551.
    10.3390/ph12040167
  15. Wieczfinska, J.; Kowalczyk, T.; Sitarek, P.; Skala, E.; Pawliczak, R.. "Analysis of short-term smoking effects in PBMC of healthy subjects—preliminary study". International Journal of Environmental Research and Public Health 15 5 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85047244635&partnerID=MN8TOARS.
    10.3390/ijerph15051021
  16. Sitarek, P.; Kowalczyk, T.; Santangelo, S.; Bialas, A.J.; Toma, M.; Wieczfinska, J.; Sliwinski, T.; Skala, E.. "The Extract of Leonurus sibiricus Transgenic Roots with AtPAP1 Transcriptional Factor Induces Apoptosis via DNA Damage and Down Regulation of Selected Epigenetic Factors in Human Cancer Cells". Neurochemical Research 43 7 (2018): 1363-1370. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047196829&partnerID=MN8TOARS.
    10.1007/s11064-018-2551-6
  17. Skala, E.; Kowalczyk, T.; Toma, M.; Szemraj, J.; Radek, M.; Pytel, D.; Wieczfinska, J.; et al. "Induction of apoptosis in human glioma cell lines of various grades through the ROS-mediated mitochondrial pathway and caspase activation by Rhaponticum carthamoides transformed root extract". Molecular and Cellular Biochemistry 445 1-2 (2018): 89-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038007367&partnerID=MN8TOARS.
    10.1007/s11010-017-3254-z
  18. Sitarek, P.; Synowiec, E.; Kowalczyk, T.; Sliwinski, T.; Skala, E.. "An in vitro estimation of the cytotoxicity and genotoxicity of root extract from Leonurus sibiricus L. overexpressing AtPAP1 against different cancer cell lines". Molecules 23 8 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053592700&partnerID=MN8TOARS.
    10.3390/molecules23082049
  19. Skala, E.; Toma, M.; Kowalczyk, T.; Sliwinski, T.; Sitarek, P.. "Rhaponticum carthamoides transformed root extract inhibits human glioma cells viability, induces double strand DNA damage, H2A.X phosphorylation, and PARP1 cleavage". Cytotechnology (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85053425862&partnerID=MN8TOARS.
    10.1007/s10616-018-0251-3
  20. Bialas, A.J.; Kornicki, K.; Ciebiada, M.; Antczak, A.; Sitarek, P.; Milkowska-Dymanowska, J.; Piotrowski, W.J.; Górski, P.. "Monocyte to large platelet ratio as a diagnostic tool of pulmonary embolism in patients with acute exacerbation of COPD". Polish Archives of Internal Medicine 128 1 (2018): 906-914. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041329755&partnerID=MN8TOARS.
    10.20452/pamw.4141
  21. Sitarek, P.; Kowalczyk, T.; Rijo, P.; Bialas, A.J.; Wielanek, M.; Wysokinska, H.; Garcia, C.; et al. "Over-Expression of AtPAP1 Transcriptional Factor Enhances Phenolic Acid Production in Transgenic Roots of Leonurus sibiricus L. and Their Biological Activities". Molecular Biotechnology 60 1 (2018): 74-82. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035797687&partnerID=MN8TOARS.
    10.1007/s12033-017-0048-1
  22. Sitarek, P.; Kowalczyk, T.; Picot, L.; Michalska-Hejduk, D.; Bijak, M.; Bialas, A.J.; Wielanek, M.; Sliwinski, T.; Skala, E.. "Growth of Leonurus sibiricus L. roots with over-expression of AtPAP1 transcriptional factor in closed bioreactor, production of bioactive phenolic compounds and evaluation of their biological activity". Industrial Crops and Products 122 (2018): 732-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050284116&partnerID=MN8TOARS.
    10.1016/j.indcrop.2018.06.059
  23. Skala, E.; Synowiec, E.; Kowalczyk, T.; Sliwinski, T.; Sitarek, P.. "Rhaponticum carthamoides transformed root extract has potent anticancer activity in human leukemia and lung adenocarcinoma cell lines". Oxidative Medicine and Cellular Longevity 2018 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85059795727&partnerID=MN8TOARS.
    10.1155/2018/8198652
  24. Bialas, A.J.; Liberski, P.P.; Zielinska, A.; Kumor-Kisielewska, A.; Szewczyk, K.; Milkowska-Dymanowska, J.; Sitarek, P.; Piotrowski, W.J.; Górski, P.. "Morphometric analysis of mitochondria in lymphocytes of patients with exacerbations of chronic obstructive pulmonary disease – Pilot study". International Journal of COPD 13 (2018): 2313-2318. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058494398&partnerID=MN8TOARS.
    10.2147/COPD.S163249
  25. Bijak, M.; Synowiec, E.; Sitarek, P.; Sliwinski, T.; Saluk-Bijak, J.. "Evaluation of the cytotoxicity and genotoxicity of flavonolignans in different cellular models". Nutrients 9 12 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85038382361&partnerID=MN8TOARS.
    10.3390/nu9121356
  26. Sitarek, P.; Skala, E.; Toma, M.; Wielanek, M.; Szemraj, J.; Skorski, T.; Bialas, A.J.; et al. "Transformed Root Extract of Leonurus sibiricus Induces Apoptosis through Intrinsic and Extrinsic Pathways in Various Grades of Human Glioma Cells". Pathology and Oncology Research 23 3 (2017): 679-687. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007507394&partnerID=MN8TOARS.
    10.1007/s12253-016-0170-6
  27. Sitarek, P.; Rijo, P.; Garcia, C.; Skala, E.; Kalemba, D.; Bialas, A.J.; Szemraj, J.; et al. "Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. And Their Chemical Composition". Oxidative Medicine and Cellular Longevity 2017 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85011578898&partnerID=MN8TOARS.
    10.1155/2017/7384061
  28. Sliwinska, A.; Sitarek, P.; Toma, M.; Czarny, P.; Synowiec, E.; Krupa, R.; Wigner, P.; et al. "Decreased expression level of BER genes in Alzheimer's disease patients is not derivative of their DNA methylation status". Progress in Neuro-Psychopharmacology and Biological Psychiatry 79 (2017): 311-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-85024115852&partnerID=MN8TOARS.
    10.1016/j.pnpbp.2017.07.010
  29. Skala, E.; Rijo, P.; Garcia, C.; Sitarek, P.; Kalemba, D.; Toma, M.; Szemraj, J.; et al. "The essential oils of rhaponticum carthamoides hairy roots and roots of soil-grown plants: Chemical composition and antimicrobial, anti-inflammatory, and antioxidant activities". Oxidative Medicine and Cellular Longevity 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85008953562&partnerID=MN8TOARS.
    10.1155/2016/8505384
  30. Skala, E.; Sitarek, P.; Toma, M.; Szemraj, J.; Radek, M.; Nieborowska-Skorska, M.; Skorski, T.; Wysokinska, H.; Sliwinski, T.. "Inhibition of human glioma cell proliferation by altered Bax/Bcl-2-p53 expression and apoptosis induction by Rhaponticum carthamoides extracts from transformed and normal roots". Journal of Pharmacy and Pharmacology 68 11 (2016): 1454-1464. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990250365&partnerID=MN8TOARS.
    10.1111/jphp.12619
  31. Skala, E.; Sitarek, P.; Rózalski, M.; Krajewska, U.; Szemraj, J.; Wysokinska, H.; Sliwinski, T.. "Antioxidant and DNA repair stimulating effect of extracts from transformed and normal roots of rhaponticum carthamoides against induced oxidative stress and DNA damage in CHO cells". Oxidative Medicine and Cellular Longevity 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84962296053&partnerID=MN8TOARS.
    10.1155/2016/5753139
  32. Sitarek, P.; Skala, E.; Wysokinska, H.; Wielanek, M.; Szemraj, J.; Toma, M.; ¿liwinski, T.. "The effect of leonurus sibiricus plant extracts on stimulating repair and protective activity against oxidative DNA damage in CHO cells and content of phenolic compounds". Oxidative Medicine and Cellular Longevity 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84953889256&partnerID=MN8TOARS.
    10.1155/2016/5738193
  33. Sitarek, P.; Skala, E.; Toma, M.; Wielanek, M.; Szemraj, J.; Nieborowska-Skorska, M.; Kolasa, M.; et al. "A preliminary study of apoptosis induction in glioma cells via alteration of the Bax/Bcl-2-p53 axis by transformed and non-transformed root extracts of Leonurus sibiricus L.". Tumor Biology 37 7 (2016): 8753-8764. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953386464&partnerID=MN8TOARS.
    10.1007/s13277-015-4714-2
  34. Bialas, A.J.; Sitarek, P.; Milkowska-Dymanowska, J.; Piotrowski, W.J.; Górski, P.. "The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease". Oxidative Medicine and Cellular Longevity 2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85009446627&partnerID=MN8TOARS.
    10.1155/2016/7808576
  35. Skala, E.; Grabkowska, R.; Sitarek, P.; Kuzma, L.; Blauz, A.; Wysokinska, H.. "Rhaponticum carthamoides regeneration through direct and indirect organogenesis, molecular profiles and secondary metabolite production". Plant Cell, Tissue and Organ Culture 123 1 (2015): 83-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941314056&partnerID=MN8TOARS.
    10.1007/s11240-015-0816-1
  36. Milonski, J.; Zielinska-Blizniewska, H.; Majsterek, I.; Przybylowska-Sygut, K.; Sitarek, P.; Korzycka-Zaborowska, B.; Olszewski, J.. "Expression of POSTN, IL-4, and IL-13 in chronic rhinosinusitis with nasal polyps". DNA and Cell Biology 34 5 (2015): 342-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928985494&partnerID=MN8TOARS.
    10.1089/dna.2014.2712
  37. Grabkowska, R.; Sitarek, P.; Wysokinska, H.. "Influence of thidiazuron (TDZ) pretreatment of shoot tips on shoot multiplication and ex vitro acclimatization of Harpagophytum procumbens". Acta Physiologiae Plantarum 36 7 (2014): 1661-1672. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903279956&partnerID=MN8TOARS.
    10.1007/s11738-014-1541-9
  38. Piatczak, E.; Kuzma, L.; Sitarek, P.; Wysokinska, H.. "Shoot organogenesis, molecular analysis and secondary metabolite production of micropropagated Rehmannia glutinosa Libosch.". Plant Cell, Tissue and Organ Culture 120 2 (2014): 539-549. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925488331&partnerID=MN8TOARS.
    10.1007/s11240-014-0620-3
  39. Sitarek, P.; Zielinska-Blizniewska, H.; Dziki, L.; Milonski, J.; Przybylowska, K.; Mucha, B.; Olszewski, J.; Majsterek, I.. "Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a polish population". DNA and Cell Biology 31 7 (2012): 1258-1266. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863959312&partnerID=MN8TOARS.
    10.1089/dna.2011.1453
  40. Sitarek, P.; Zielinska-Blizniewska, H.; Milonski, J.; Przybylowska, K.; Majsterek, I.; Olszewski, J.. "Role of the -765 G/C polymorphism of COX-2 gene in pathogenesis of chronic rhinosinusitis with nose polyps in a Polish population,Znaczenie polimorfizmu -765G/C genu COX-2 dla patogenezy przewleklego zapalenia zatok przynosowych z polipami nosa w populacji polskiej". Otolaryngologia Polska 66 3 (2012): 181-184. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863185684&partnerID=MN8TOARS.
    10.1016/S0030-6657(12)70766-7
  41. Zielinska-Blizniewska, H.; Sitarek, P.; Milonski, J.; Dziki, L.; Przybylowska, K.; Olszewski, J.; Majsterek, I.. "Association of the 233C/G OSF-2 and the 140A/G LF gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population". Molecular Biology Reports 39 5 (2012): 5449-5457. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863731014&partnerID=MN8TOARS.
    10.1007/s11033-011-1345-6
  42. Sliwinski, T.; Sitarek, P.; Stetkiewicz, T.; Sobczuk, A.; Blasiak, J.. "Polymorphism of the ERa and CYP1B1 genes in endometrial cancer in a Polish subpopulation". Journal of Obstetrics and Gynaecology Research 36 2 (2010): 311-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950271312&partnerID=MN8TOARS.
    10.1111/j.1447-0756.2009.01143.x
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2018/10/01 - 2019/06/24 MOLECULAR ANALYSIS OF THE HAIRY ROOTS OF LEONOTIS NEPETIFOLIA (L.) R.Br. FOR THE PRESENCE OF A TRANSGENE ENCODING THE GENE OF DXP REDUCTOISOMERASE (DXR) AND BIOLOGICAL PROPERTIES OF OBTAINED EXTRACTS
Orientador
Master degree (Mestrado)
Uniwersytet Medyczny w Lodzi, Polónia
Distinções

Prémio

2019 Rector's Award for a series of publications
Uniwersytet Medyczny w Lodzi, Polónia