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I am a medical doctor, specialized in Allergy and Clinical Immunology (2014), with a PhD in Immunology (2018). Currently I am working as a clinician (since 2022) and as Co-Health director (since 2023) at GAT: Portuguese Activist Group on Treatments, founded in 2001, a structure of individual membership and cooperation between people from different communities and organizations affected by HIV and AIDS, sexually transmitted infections, viral hepatitis, and tuberculosis.GAT is a non governamental, non-profit organization with Health purposes and headquartered in Lisbon. GAT advocates for legal and policy changes that positively affect the health, rights, and quality of life of people living with HIV or at risk of becoming infected. GAT intends to contribute to the objectives of UNAIDS, as well as the United Nations Sustainable Development Goals, mainly the third, providing answers that allow influencing the goals that are within its reach through a strategic intervention in key areas of public health policies with the involvement of the communities most affected and vulnerable to these infections in the provision of care and the definition of best practices and policies, in full respect of human rights, good practices, and international policies. GAT's activities are based on the following areas of intervention: prevention; early diagnosis and access to health services; treatment; discrimination and Stigma; knowledge Production. In my previous role, I worked as a post-doctoral researcher at the Human Immunodeficiency & Immune Reconstitution Lab at the Instituto de Medicina Molecular João Lobo Antunes (Faculty of Medicine of Lisbon University) (2018-2022). Moreover, I have published several papers focusing on clinical and immunological aspects of viral infections, acquired and congenital immune deficiencies, and autoimmune diseases. I have also contributed to book chapters on basic immunology. In addition, I have had the opportunity to supervise BSc and MSc students and serve as a jury member for their MSc theses. To enhance my knowledge and skills, I have attended courses in diverse areas including Biosafety Level 3, biostatistics, and R programming. I have received grants for my research projects, such as the Gilead Geneses grant (2019) as a principal investigator, which supported my research on the role of myeloid cells in the different courses of HIV-1 and HIV-2 infection. Furthermore, I was awarded a Research 4COVID-19 grant from the Portuguese Foundation for Science and Technology (FCT) in 2020 for a project on myeloid cell activation and phenotype in SARS-COV-2 infected patients with severe symptoms.
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Identificação

Identificação pessoal

Nome completo
Amelia Chiara Trombetta

Nomes de citação

  • Trombetta AC

Identificadores de autor

Ciência ID
621C-FC03-9CE9
ORCID iD
0000-0003-3285-3086

Endereços de correio eletrónico

  • amelia.trombetta@medicina.ulisboa.pt (Profissional)
  • lia.trombetta@gatportugal.org (Profissional)
  • ameliachiarat@yahoo.it (Pessoal)

Moradas

  • Grupo de Activistas em Tratamentos (GAT). Avenida Paris, 4 - 1º Direito, 1000-228, Lisboa, Lisboa, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Médicas e da Saúde - Medicina Clínica - Reumatologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Italiano (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador independente (B2) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador independente (B2)
Formação
Grau Classificação
2018/10/04 - 2022/06/01
Concluído
 "Follicular T cells at the heart of HIV infection" (HIV-2Cure) (Pós-doutoramento)
Instituto de Medicina Molecular, Portugal
2014/11/01 - 2017/11/01
Concluído
 Clinical and experimental Immunology (Doctor of Philosophy)
Especialização em Research Laboratory and Academic Division of Clinical Rheumatology
Centro di Eccellenza per lo studio dei meccanismi molecolari di comunicazione tra cellule: dalla ricerca di base alla clinica (CEBR), Itália

Università degli Studi di Genova, Itália
"CHARACTERIZATION OF A POPULATION OF CELLS EXPRESSING BOTH M1 AND M2 MACROPHAGE SURFACE MARKERS IN SYSTEMIC SCLEROSIS: CASE-CONTROL STUDY AND CORRELATIONS WITH CLINICAL PARAMETERS " (TESE/DISSERTAÇÃO)
2009/07/01 - 2014/07/01
Concluído
 Specialty training in Allergy and Clinical Immunology (Postgraduate Certificate)
Università degli Studi di Roma La Sapienza, Itália
"The Role of Cardiovascular Magnetic Resonance in the early diagnosis of scleroderma heart disease" (TESE/DISSERTAÇÃO)
2002/09/01 - 2008/09/30
Concluído
 Medicine (Laurea Magistrale)
Università degli Studi di Roma La Sapienza, Itália
"Ataxia Telangiectasia: Italian multicenter study" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/10/04 - 2022/06/01 Pós-doutorado (Investigação) Instituto de Medicina Molecular, Portugal
Instituto de Medicina Molecular, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/10/20 - 2022/06/01 Professor Auxiliar Convidado (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/08/01 - Atual Clinician and Co-Health Director GAT - Grupo de Ativistas em Tratamentos, Portugal
Projetos

Bolsa

Designação Financiadores
2020/05/04 - Atual COVID-19 pneumonia outcome: an immunological approach
125_596759906
Investigador Pós-doutorado
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/01/01 - Atual Monocyte and macrophage contribute to the different pathogenesis of HIV-2 compared to HIV-1 infection: clinical correlations and therapeutic perspectives
Gilead Genese 2019
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Gilead Sciences Lda
Em curso
2020/06/30 - 2021/06/01 COVID-19 prognosis: innate immune determinants
803
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso

Outro

Designação Financiadores
2018/10/04 - 2021/04/04 "Follicular T cells at the hearth of HIV infection" (HIV2CURE)
PTDC/MED-IMU/30474/2017
Bolseiro de Pós-Doutoramento
Instituto de Medicina Molecular, Portugal
Produções

Publicações

Artigo em revista
  1. Gomes, André M. C.; Farias, Guilherme B.; Trombetta, Amelia C.; Godinho-Santos, Ana; Parreira, Inês; Gonçalves, Hélder Diogo; Simões, Mariana Lessa; et al. "Phenotype of BTK lacking myeloid cells during prolonged COVID-19 and upon convalescent plasma". European Journal of Haematology 110 2 (2022): 209-212. http://dx.doi.org/10.1111/ejh.13881.
    10.1111/ejh.13881
  2. Guilherme B. Farias; Robert Badura; Carolina M Conceição; André Gomes; Ana Godinho-Santos; Joel Laia; Pedro Rosmaninho; et al. "Acute HIV-1 and SARS-CoV-2 Infections Share Slan+ Monocyte Depletion—Evidence from an Hyperacute HIV-1 Case Report". Viruses (2021): https://www.mdpi.com/1999-4915/13/9/1805.
    10.3390/v13091805
  3. Trombetta, Amelia C.; Farias, Guilherme B.; Gomes, André M. C.; Godinho-Santos, Ana; Rosmaninho, Pedro; Conceição, Carolina M.; Laia, Joel; et al. "Severe COVID-19 Recovery Is Associated with Timely Acquisition of a Myeloid Cell Immune-Regulatory Phenotype". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.691725.
    10.3389/fimmu.2021.691725
  4. Galea, Nicola; Rosato, Edoardo; Gigante, Antonietta; Borrazzo, Cristian; Fiorelli, Andrea; Barchetti, Giovanni; Trombetta, Amelia Chiara; et al. "Early myocardial damage and microvascular dysfunction in asymptomatic patients with systemic sclerosis: A cardiovascular magnetic resonance study with cold pressor test". PLOS ONE 15 12 (2020): e0244282. http://dx.doi.org/10.1371/journal.pone.0244282.
    10.1371/journal.pone.0244282
  5. Robert Badura; Russel B. Foxall; Dario Ligeiro; Miguel Rocha; Ana Godinho-Santos; Trombetta AC; Ana E. Sousa. "Early ART in Acute HIV-1 Infection: Impact on the B-Cell Compartment". Frontiers in Cellular and Infection Microbiology (2020):
  6. Pacini, Greta; Paolino, Sabrina; C. Trombetta, Amelia; Goegan, Federica; Pizzorni, Carmen; Alessandri, Elisa; Patanè, Massimo; et al. "Lower urinary tract symptoms in systemic sclerosis: a detailed investigation". Rheumatology (2019): http://dx.doi.org/10.1093/rheumatology/kez601.
    10.1093/rheumatology/kez601
  7. Trombetta AC; Cutolo, Maurizio; Trombetta, Amelia Chiara; Soldano, Stefano. "Monocyte and macrophage phenotypes: a look beyond systemic sclerosis". Annals of the Rheumatic Diseases (2018): annrheumdis-2018. http://dx.doi.org/10.1136/annrheumdis-2018-214371.
    10.1136/annrheumdis-2018-214371
  8. Cutolo, Maurizio; Trombetta, Amelia Chiara; Soldano, Stefano. "Monocyte and macrophage phenotypes: a look beyond systemic sclerosis. Response to: 'M1/M2 polarisation state of M-CSF blood-derived macrophages in systemic sclerosis' by Lescoat et al". Annals of the Rheumatic Diseases 78 11 (2018): e128-e128. http://dx.doi.org/10.1136/annrheumdis-2018-214371.
    10.1136/annrheumdis-2018-214371
  9. Trombetta, Amelia Chiara; Soldano, Stefano; Contini, Paola; Tomatis, Veronica; Ruaro, Barbara; Paolino, Sabrina; Brizzolara, Renata; et al. "A circulating cell population showing both M1 and M2 monocyte/macrophage surface markers characterizes systemic sclerosis patients with lung involvement". Respiratory Research 19 1 (2018): http://dx.doi.org/10.1186/s12931-018-0891-z.
    10.1186/s12931-018-0891-z
  10. Cutolo, Maurizio; Vanhaecke, Amber; Ruaro, Barbara; Deschepper, Ellen; Ickinger, Claudia; Melsens, Karin; Piette, Yves; et al. "Is laser speckle contrast analysis (LASCA) the new kid on the block in systemic sclerosis? A systematic literature review and pilot study to evaluate reliability of LASCA to measure peripheral blood perfusion in scleroderma patients". Autoimmunity Reviews 17 8 (2018): 775-780. http://dx.doi.org/10.1016/j.autrev.2018.01.023.
    10.1016/j.autrev.2018.01.023
  11. Cutolo, Maurizio; Soldano, Stefano; Montagna, Paola; Trombetta, Amelia Chiara; Contini, Paola; Ruaro, Barbara; Sulli, Alberto; et al. "Effects of CTLA4-Ig treatment on circulating fibrocytes and skin fibroblasts from the same systemic sclerosis patients: an in vitro assay". Arthritis Research & Therapy 20 1 (2018): http://dx.doi.org/10.1186/s13075-018-1652-6.
    10.1186/s13075-018-1652-6
  12. Soldano, Stefano; Trombetta, Amelia Chiara; Contini, Paola; Tomatis, Veronica; Ruaro, Barbara; Brizzolara, Renata; Montagna, Paola; et al. "Increase in circulating cells coexpressing M1 and M2 macrophage surface markers in patients with systemic sclerosis". Annals of the Rheumatic Diseases 77 12 (2018): 1842-1845. http://dx.doi.org/10.1136/annrheumdis-2018-213648.
    10.1136/annrheumdis-2018-213648
  13. Pizzorni, C.; Cutolo, M.; Sulli, A.; Ruaro, B.; Trombetta, A. C.; Ferrari, G.; Pesce, G.; Smith, V.; Paolino, S.. "Long-term follow-up of nailfold videocapillaroscopic changes in dermatomyositis versus systemic sclerosis patients". Clinical Rheumatology 37 10 (2018): 2723-2729. http://dx.doi.org/10.1007/s10067-018-4211-2.
    10.1007/s10067-018-4211-2
  14. Cutolo, Maurizio; Ruaro, Barbara; Montagna, Paola; Brizzolara, Renata; Stratta, Emanuela; Trombetta, Amelia Chiara; Scabini, Stefano; et al. "Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts". Arthritis Research & Therapy 20 1 (2018): http://dx.doi.org/10.1186/s13075-018-1577-0.
    10.1186/s13075-018-1577-0
  15. Cutolo, Maurizio; Trombetta, Amelia C.; Melsens, Karin; Pizzorni, Carmen; Sulli, Alberto; Ruaro, Barbara; Paolino, Sabrina; Deschepper, Ellen; Smith, Vanessa. "Automated assessment of absolute nailfold capillary number on videocapillaroscopic images: Proof of principle and validation in systemic sclerosis". Microcirculation 25 4 (2018): e12447. http://dx.doi.org/10.1111/micc.12447.
    10.1111/micc.12447
  16. Cutolo, Maurizio; Melsens, Karin; Herrick, Ariane L.; Foeldvari, Ivan; Deschepper, Ellen; De Keyser, Filip; Distler, Oliver; et al. "Reliability of simple capillaroscopic definitions in describing capillary morphology in rheumatic diseases". Rheumatology 57 4 (2018): 757-759. http://dx.doi.org/10.1093/rheumatology/kex460.
    10.1093/rheumatology/kex460
  17. Ruaro, B.; Sulli, A.; Pizzorni, C.; Paolino, S.; Smith, V.; Alessandri, E.; Trombetta, A.C.; Alsheyyab, J.; Cutolo, M.. "Correlations between blood perfusion and dermal thickness in different skin areas of systemic sclerosis patients". Microvascular Research 115 (2018): 28-33. http://dx.doi.org/10.1016/j.mvr.2017.08.004.
    10.1016/j.mvr.2017.08.004
  18. PIZZORNI, CARMEN; SULLI, ALBERTO; PAOLINO, SABRINA; RUARO, BARBARA; SMITH, VANESSA; TROMBETTA, AMELIA CHIARA; CUTOLO, MAURIZIO. "Progression of Organ Involvement in Systemic Sclerosis Patients with Persistent “Late” Nailfold Capillaroscopic Pattern of Microangiopathy: A Prospective Study". The Journal of Rheumatology 44 12 (2017): 1941-1942. http://dx.doi.org/10.3899/jrheum.170485.
    10.3899/jrheum.170485
  19. Trombetta, Amelia Chiara; Smith, Vanessa; Gotelli, Emanuele; Ghio, Massimo; Paolino, Sabrina; Pizzorni, Carmen; Vanhaecke, Amber; et al. "Vitamin D deficiency and clinical correlations in systemic sclerosis patients: A retrospective analysis for possible future developments". PLOS ONE 12 6 (2017): e0179062. http://dx.doi.org/10.1371/journal.pone.0179062.
    10.1371/journal.pone.0179062
  20. Stefano Soldano; Sabrina Paolino; Carmen Pizzorni; Trombetta AC; Paola Montagna; Renata Brizzolara; Claudio Corallo; et al. "Dual endothelin receptor antagonists contrast the effects induced by endothelin-1 on cultured human microvascular endothelial cells". Clinical and Experimental Rheumatology (2017):
  21. Soldano, Stefano; Pizzorni, Carmen; Paolino, Sabrina; Trombetta, Amelia Chiara; Montagna, Paola; Brizzolara, Renata; Ruaro, Barbara; Sulli, Alberto; Cutolo, Maurizio. "Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages". PLOS ONE 11 11 (2016): e0166433. http://dx.doi.org/10.1371/journal.pone.0166433.
    10.1371/journal.pone.0166433
  22. Pizzorni, Carmen; Sulli, Alberto; Smith, Vanessa; Ruaro, Barbara; Trombetta, Amelia Chiara; Cutolo, Maurizio; Paolino, Sabrina. "Primary Raynaud’s phenomenon and nailfold videocapillaroscopy: age-related changes in capillary morphology". Clinical Rheumatology 36 7 (2016): 1637-1642. http://dx.doi.org/10.1007/s10067-016-3442-3.
    10.1007/s10067-016-3442-3
  23. Trombetta, Amelia Chiara; Pizzorni, Carmen; Ruaro, Barbara; Paolino, Sabrina; Sulli, Alberto; Smith, Vanessa; Cutolo, Maurizio. "Effects of Longterm Treatment with Bosentan and Iloprost on Nailfold Absolute Capillary Number, Fingertip Blood Perfusion, and Clinical Status in Systemic Sclerosis". The Journal of Rheumatology 43 11 (2016): 2033-2041. http://dx.doi.org/10.3899/jrheum.160592.
    10.3899/jrheum.160592
  24. Smith, Vanessa; Thevissen, Kristof; Trombetta, Amelia C.; Pizzorni, Carmen; Ruaro, Barbara; Piette, Yves; Paolino, Sabrina; et al. "Nailfold Capillaroscopy and Clinical Applications in Systemic Sclerosis". Microcirculation 23 5 (2016): 364-372. http://dx.doi.org/10.1111/micc.12281.
    10.1111/micc.12281
  25. Trombetta, Amelia Chiara; Smith, Vanessa; Pizzorni, Carmen; Meroni, Marianna; Paolino, Sabrina; Cariti, Caterina; Ruaro, Barbara; Sulli, Alberto; Cutolo, Maurizio. "Quantitative Alterations of Capillary Diameter Have a Predictive Value for Development of the Capillaroscopic Systemic Sclerosis Pattern". The Journal of Rheumatology 43 3 (2016): 599-606. http://dx.doi.org/10.3899/jrheum.150900.
    10.3899/jrheum.150900
  26. Rosato, E.; Rossi, C.; Molinaro, I.; Digiulio, M.A.; Trombetta, A.C.; Marra, A.M.; Gigante, A.; et al. "Sexual Distress, Sexual Dysfunction and Relationship Quality in Women with Systemic Sclerosis: Correlation with Clinical Variables". International Journal of Immunopathology and Pharmacology 27 2 (2014): 279-285. http://dx.doi.org/10.1177/039463201402700216.
    10.1177/039463201402700216
  27. Quinti, Isabella; Soresina, Annarosa; Guerra, Andrea; Rondelli, Roberto; Spadaro, Giuseppe; Agostini, Carlo; Milito, Cinzia; et al. "Effectiveness of Immunoglobulin Replacement Therapy on Clinical Outcome in Patients with Primary Antibody Deficiencies: Results from a Multicenter Prospective Cohort Study". Journal of Clinical Immunology 31 3 (2011): 315-322. http://dx.doi.org/10.1007/s10875-011-9511-0.
    10.1007/s10875-011-9511-0
  28. Visentini, Marcella; Conti, Valentina; Cagliuso, Maria; Tinti, Francesca; Siciliano, Giulia; Trombetta, Amelia C.; Mitterhofer, Anna Paola; Fiorilli, Massimo; Quinti, Isabella. "Regression of systemic lupus erythematosus after development of an acquired Toll-like receptor signaling defect and antibody deficiency". Arthritis & Rheumatism 60 9 (2009): 2767-2771. http://dx.doi.org/10.1002/art.24760.
    10.1002/art.24760
Capítulo de livro
  1. Cutolo, Maurizio; Trombetta, Amelia Chiara. "Neuroendocrine Involvement in Immune-Mediated Rheumatic Diseases". In Endocrinology and Systemic Diseases, 263-279. Springer International Publishing, 2020.
    Publicado • 10.1007/978-3-319-68729-2_9
  2. Cutolo, Maurizio; Trombetta, Amelia Chiara. "Neuroimmunology". In Mosaic of Autoimmunity, 601-608. Elsevier, 2019.
    Publicado • 10.1016/b978-0-12-814307-0.00055-4
  3. Trombetta, Amelia Chiara; Meroni, Marianna; Cutolo, Maurizio. "Steroids and Autoimmunity". In Frontiers of Hormone Research, 121-132. S. Karger AG, 2017.
    10.1159/000452911
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/03/06 Timely acquisition of myeloid cell immune-regulatory phenotype and COVID-19 outcome Conference on Retroviruses and Opportunistic Infections (CROI) 2021
2021/01/27 LONGITUDINAL PROFILING OF INNATE IMMUNE RESPONSE IN COVID-19 PATIENTS Immunology Club
Instituto de Medicina Molecular João Lobo Antunes (Lisbon, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/07/01 - Atual New unsupervised approaches for the study of immune cells in SARS-CoV-2 and HIV patients
Orientador
 Ciências Biofarmacêuticas
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/05/01 - Atual Shaping monocyte / macrophage system role in acute and chronic viral infection
Coorientador
 Investigação Biomédica (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
2019/03/01 - 2020/07/29 Modelling strategies to assess the role of monocytes and macrophages in HIV/AIDS pathogenesis – Optimisation of protocols for ex-vivo monocyte/macrophage phenotyping, isolation, and in-vitro differentiation
Orientador
 Medicina (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2021/12/22 Phenotyping Circulating Monocytes and Dendritic Cells in SARS-CoV-2 and HIV Infections
Orientador
 Guilherme Farias (Mestrado)
Universidade de Coimbra, Portugal
2020/07/29 Modelling strategies to assess the role of monocytes and macrophages in HIV/AIDS pathogenesis Optimisation of protocols for ex-vivo monocyte/macrophage phenotyping, isolation, and in-vitro differentiation.
Orientador
 Joana Merciano Labisa (Mestrado)
Instituto de Medicina Molecular, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/10/20 - 2021/06/01 I participated to theoretical and practical teaching of Clinical Immunology in the context of the Módulo V.II - Medicina II, Disciplina Optativa de Imunologia Clínica (S1+S2), Disciplina optativa de Praticas Clinicas Tutoriais de Imunologia Clinica (S1+S2). Medicina (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2021/01/07 - 2021/01/20 Participation to candidate evaluation for the attribution of a scholarship financed by JANSSEN- CILAG FARMACÊUTICA, LDA, to a master student, for the project “PROGRAMA DE APOIO A BOLSAS DE INVESTIGAÇÃO CIENTÍFICA”. Instituto de Medicina Molecular, Portugal
Distinções

Prémio

2021 New Investigator Scholarship to attend virtual CROI 2021

Outra distinção

2017 Special Educational Grant by EULAR for the Epidemiology Course in Berlin, 30 June - 1 July 2017