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Diana Sousa Duarte. Born in Porto in 1995 and currently living in Esposende. Received undergraduate and master's degrees in Biochemistry from the University of Porto, where focused on microbiology research and peptide synthesis. Completed my Ph.D. in 2023 in Pharmaceutical Sciences, specializing in Pharmacology and Pharmacotherapy. My research is focused on the development of new pharmacological combinations for colon and breast cancer combat. To date, I have published over 30 scientific papers in international journals and collaborated with more than 50 researchers on scientific projects.
Identificação

Identificação pessoal

Nome completo
Diana Sousa Duarte
Data de nascimento
1995/01/13
Género
Feminino

Nomes de citação

  • Duarte, Diana

Identificadores de autor

Ciência ID
651D-65B4-BDED
ORCID iD
0000-0003-1420-5042
Google Scholar ID
eOtjI08AAAAJ&hl
Researcher Id
ABA-2082-2020
Scopus Author Id
57194509580

Endereços de correio eletrónico

  • up201201433@fc.up.pt (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2019/01/01 - 2022/01/01
Em curso
Ciências Farmacêuticas (Doutoramento)
Especialização em Farmacologia e Farmacoterapia
Universidade do Porto Faculdade de Farmácia, Portugal
2015/09/15 - 2017/11/15
Concluído
Bioquímica (Mestrado)
Especialização em Sem especialização
Universidade do Porto Faculdade de Ciências, Portugal
"Development of Peptide-Thiazole Conjugates and In vitro Studies on the Inhibition of Colon Cancer" (TESE/DISSERTAÇÃO)
18 valores
2012 - 2015
Concluído
Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
" Comparação da eficácia de diferentes meios de cultura na deteção de bacilos de gram-negativo em amostras ambientais, humanas e animais " (TESE/DISSERTAÇÃO)
15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2018/04/01 - 2018/12/31 Investigador (Investigação) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
Produções

Publicações

Artigo em revista
  1. Amina El Mihyaoui; Saoulajan Charfi; El Hadi Erbiai; Mariana Pereira; Diana Duarte; Nuno Vale; María Emilia Candela Castillo; et al. "Phytochemical Compounds and Anticancer Activity of Cladanthus mixtus Extracts from Northern Morocco". Cancers (2022): https://doi.org/10.3390/cancers15010152.
    10.3390/cancers15010152
  2. Nuno Vale; Mariana Pereira; Joana Santos; Catarina Moura; Lara Marques; Diana Duarte. "Prediction of Drug Synergism between Peptides and Antineoplastic Drugs Paclitaxel, 5-Fluorouracil, and Doxorubicin Using In Silico Approaches". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms24010069.
    10.3390/ijms24010069
  3. Mariana Nunes; Diana Duarte; Nuno Vale; Sara Ricardo. "The Antineoplastic Effect of Carboplatin Is Potentiated by Combination with Pitavastatin or Metformin in a Chemoresistant High-Grade Serous Carcinoma Cell Line". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms24010097.
    10.3390/ijms24010097
  4. Carla M. Magalhães; Patricia González-Berdullas; Mariana Pereira; Diana Duarte; Nuno Vale; Joaquim C. G. Esteves da Silva; Luís Pinto da Silva. "Investigation of the Anticancer and Drug Combination Potential of Brominated Coelenteramines toward Breast and Prostate Cancer". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232213981.
    10.3390/ijms232213981
  5. Diana Duarte; Nuno Vale. "Antidepressant Drug Sertraline against Human Cancer Cells". Biomolecules (2022): https://doi.org/10.3390/biom12101513.
    10.3390/biom12101513
  6. Diana Duarte; Mariana Nunes; Sara Ricardo; Nuno Vale. "Combination of Antimalarial and CNS Drugs with Antineoplastic Agents in MCF-7 Breast and HT-29 Colon Cancer Cells: Biosafety Evaluation and Mechanism of Action". Biomolecules (2022): https://doi.org/10.3390/biom12101490.
    10.3390/biom12101490
  7. Diana Duarte; Inês Guerreiro; Nuno Vale. "Novel Strategies for Cancer Combat: Drug Combination Using Repurposed Drugs Induces Synergistic Growth Inhibition of MCF-7 Breast and HT-29 Colon Cancer Cells". Current Issues in Molecular Biology (2022): https://doi.org/10.3390/cimb44100335.
    10.3390/cimb44100335
  8. Diana Duarte; Nuno Vale. "Antipsychotic Drug Fluphenazine against Human Cancer Cells". Biomolecules (2022): https://doi.org/10.3390/biom12101360.
    10.3390/biom12101360
  9. Mariana Nunes; Diana Duarte; Nuno Vale; Sara Ricardo. "Pitavastatin and Ivermectin Enhance the Efficacy of Paclitaxel in Chemoresistant High-Grade Serous Carcinoma". Cancers (2022): https://doi.org/10.3390/cancers14184357.
    10.3390/cancers14184357
  10. Sara Silva; Joana Marto; Lídia M. Gonçalves; Diana Duarte; O. Salomé G. P. Soares; Francisco Vasques-Nóvoa; António J. Almeida; Nuno Vale. "New Peptide Functionalized Nanostructured Lipid Carriers with CNS Drugs and Evaluation Anti-proliferative Activity". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23137109.
    10.3390/ijms23137109
  11. Rafaela Rodrigues; D. Duarte; Nuno Vale. "Drug Repurposing in Cancer Therapy: Influence of Patient’s Genetic Background in Breast Cancer Treatment". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/8/4280.
    10.3390/ijms23084280
  12. "Potential Translational Thioflavin T Methodology as a Complement of Cell-Based Assays and after Drug Exposition". International Journal of Translational Medicine 2 2 (2022): 134-147. http://dx.doi.org/10.3390/ijtm2020011.
    10.3390/ijtm2020011
  13. Diana Duarte; Soraia I. Falcão; Iouraouine El Mehdi; Miguel Vilas-Boas; Nuno Vale. "Honeybee Venom Synergistically Enhances the Cytotoxic Effect of CNS Drugs in HT-29 Colon and MCF-7 Breast Cancer Cell Lines". Pharmaceutics 14 3 (2022): 511-511. https://doi.org/10.3390/pharmaceutics14030511.
    10.3390/pharmaceutics14030511
  14. Diana Duarte; Alexandra Rêma; Irina Amorim; Nuno Vale. "Drug Combinations: A New Strategy to Extend Drug Repurposing and Epithelial-Mesenchymal Transition in Breast and Colon Cancer Cells". Biomolecules 12 2 (2022): 190-190. https://doi.org/10.3390/biom12020190.
    10.3390/biom12020190
  15. Diana Duarte; Nuno Vale. "Combining repurposed drugs to treat colorectal cancer". Drug Discovery Today (2022): https://doi.org/10.1016/j.drudis.2021.09.012.
    10.1016/j.drudis.2021.09.012
  16. "Evaluation of synergism in drug combinations and reference models for future orientations in oncology". Current Research in Pharmacology and Drug Discovery 3 (2022): 100110-100110. http://dx.doi.org/10.1016/j.crphar.2022.100110.
    10.1016/j.crphar.2022.100110
  17. Diana Duarte; Nuno Vale. "Synergistic Interaction of CPP2 Coupled with Thiazole Derivates Combined with Clotrimazole and Antineoplastic Drugs in Prostate and Colon Cancer Cell Lines". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms222111984.
    10.3390/ijms222111984
  18. "How Antimalarials and Antineoplastic Drugs can Interact in Combination Therapies: A Perspective on the Role of PPT1 Enzyme". Current Drug Metabolism 22 13 (2021): 1009-1016. http://dx.doi.org/10.2174/1389200222666211118114057.
    10.2174/1389200222666211118114057
  19. Ana Salomé Correia; Diana Duarte; Isabel Silva; Henrique Reguengo; José Carlos Oliveira; Nuno Vale. "Serotonin after ß-Adrenoreceptors’ Exposition: New Approaches for Personalized Data in Breast Cancer Cells". Journal of Personalized Medicine (2021): https://doi.org/10.3390/jpm11100954.
    10.3390/jpm11100954
  20. Carla M. Magalhães; Patricia González-Berdullas; Diana Duarte; Ana Salomé Correia; José E. Rodríguez-Borges; Nuno Vale; Joaquim C. G. Esteves da Silva; Luís Pinto da Silva. "Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer Activity by Applying the Heavy-Atom Effect". Biomedicines 9 9 (2021): 1199-1199. https://doi.org/10.3390/biomedicines9091199.
    10.3390/biomedicines9091199
  21. Ana Carolina P. Afonso; Ana Salomé Correia; Diana Duarte; Ana T. S. C. Brandão; Maria del Valle Martínez de Yuso; José Jiménez-Jiménez; Nuno Vale; et al. "An Active Surface Preservation Strategy for the Rational Development of Carbon Dots as pH-Responsive Fluorescent Nanosensors". Chemosensors 9 8 (2021): 191-191. https://doi.org/10.3390/chemosensors9080191.
    10.3390/chemosensors9080191
  22. Diana Duarte; Armando Cardoso; Nuno Vale. "Synergistic Growth Inhibition of HT-29 Colon and MCF-7 Breast Cancer Cells with Simultaneous and Sequential Combinations of Antineoplastics and CNS Drugs". International Journal of Molecular Sciences 22 14 (2021): 7408-7408. https://doi.org/10.3390/ijms22147408.
    10.3390/ijms22147408
  23. Nuno Vale; Sara Silva; Diana Duarte; Diana M. A. Crista; Luís Pinto da Silva; Joaquim C. G. Esteves da Silva. "Normal breast epithelial MCF-10A cells to evaluate the safety of carbon dots". RSC Medicinal Chemistry (2021): https://doi.org/10.1039/D0MD00317D.
    10.1039/D0MD00317D
  24. Sara Silva; Cláudia Alves; Diana Duarte; Ana Costa; Bruno Sarmento; António J. Almeida; Paula Gomes; Nuno Vale. "Model Amphipathic Peptide Coupled with Tacrine to Improve Its Antiproliferative Activity". International Journal of Molecular Sciences 22 1 (2020): 242-242. https://doi.org/10.3390/ijms22010242.
    10.3390/ijms22010242
  25. Diana Duarte; Nuno Vale. "New Trends for Antimalarial Drugs: Synergism between Antineoplastics and Antimalarials on Breast Cancer Cells". Biomolecules (2020): https://doi.org/10.3390/biom10121623.
    10.3390/biom10121623
  26. Duarte, Diana. "Cell-penetrating peptides in oncologic pharmacotherapy: A review". Pharmacological Research (2020): 105231-105231. http://dx.doi.org/10.1016/j.phrs.2020.105231.
    10.1016/j.phrs.2020.105231
  27. Cristiana Correia; Cristina P. R. Xavier; Diana Duarte; Abigail Ferreira; Sara Moreira; M. Helena Vasconcelos; Nuno Vale. "Development of potent CPP6–gemcitabine conjugates against human prostate cancer cell line (PC-3)". RSC Medicinal Chemistry (2020): https://doi.org/10.1039/C9MD00489K.
    10.1039/C9MD00489K
  28. Nuno Vale; Diana Duarte; Alexandra Correia; Cláudia Alves; Patrícia Figueiredo; Hélder A. Santos. "New insights into ethionamide metabolism: influence of oxidized methionine on its degradation path". RSC Medicinal Chemistry (2020): https://doi.org/10.1039/D0MD00253D.
    10.1039/D0MD00253D
  29. Pinto da Silva, Luís; Núnez-Montenegro, Ara; Magalhães, Carla M.; Ferreira, Paulo J.O.; Duarte, Diana; González-Berdullas, Patricia; Rodríguez-Borges, José E.; Vale, Nuno; Esteves da Silva, Joaquim C.G.. "Single-molecule chemiluminescent photosensitizer for a self-activating and tumor-selective photodynamic therapy of cancer". European Journal of Medicinal Chemistry 183 (2019): 111683. http://dx.doi.org/10.1016/j.ejmech.2019.111683.
    Publicado • 10.1016/j.ejmech.2019.111683
  30. Duarte, Diana. "Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Leading to the Formation of Indole-3-Acetonitrile, a Pro-Proliferative Metabolite". Biomolecules (2019): http://dx.doi.org/10.3390/biom9090409.
    10.3390/biom9090409
  31. Duarte, Diana. "Study of the Combination of Self-Activating Photodynamic Therapy and Chemotherapy for Cancer Treatment". Biomolecules (2019): http://dx.doi.org/10.3390/biom9080384.
    10.3390/biom9080384
  32. Duarte, Diana; Fraga, Alexandra G.; Pedrosa, Jorge; Martel, Fátima; Vale, Nuno. "Increasing the potential of cell-penetrating peptides for cancer therapy using a new pentagonal scaffold". European Journal of Pharmacology 860 (2019): 172554. http://dx.doi.org/10.1016/j.ejphar.2019.172554.
    Publicado • 10.1016/j.ejphar.2019.172554
  33. Vale, Nuno; Correia-Branco, Ana; Patrício, Bárbara; Duarte, Diana; Martel, Fátima. "In vitro studies on the inhibition of colon cancer by amino acid derivatives of bromothiazole". Bioorganic & Medicinal Chemistry Letters 27 15 (2017): 3507-3510. http://dx.doi.org/10.1016/j.bmcl.2017.05.073.
    10.1016/j.bmcl.2017.05.073