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Alexander Hal Drakesmith. Completed the Doctor of Philosophy in Tumour Immunology in 1998/04/01 by University College London Division of Biosciences and Bachelor in Natural Sciences in 1993/06/01 by University of Cambridge. Is Principal Investigator in University of Oxford Radcliffe Department of Medicine.
Identificação

Identificação pessoal

Nome completo
Alexander Hal Drakesmith

Nomes de citação

  • Drakesmith, Alexander

Identificadores de autor

Ciência ID
681D-CB2A-E96E
ORCID iD
0000-0002-8503-6103
Google Scholar ID
https://scholar.google.co.uk/citations?user=BEzgm-kAAAAJ&hl=en

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês (Idioma materno)
Formação
Grau Classificação
1994/06/01 - 1998/04/01
Concluído
 Tumour Immunology (Doctor of Philosophy)
University College London Division of Biosciences, Reino Unido
"“Role of dendritic cells in anti-tumour immunity and autoimmunity.” " (TESE/DISSERTAÇÃO)
 Pass
1990/10/01 - 1993/06/01
Concluído
 Natural Sciences (Bachelor)
Especialização em Biochemistry
University of Cambridge, Reino Unido
 2:1
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1998/04/20 - Atual Investigador principal (carreira) (Investigação) University of Oxford Radcliffe Department of Medicine, Reino Unido
Produções

Publicações

Artigo em revista
  1. Drakesmith, Alexander. "Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia.". Blood (2020): https://doi.org/10.1182/blood.2019003140.
    10.1182/blood.2019003140
  2. Drakesmith, Alexander. "Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia.". The Lancet. Global health (2019): https://europepmc.org/articles/PMC7109523.
    10.1016/S2214-109X(19)30393-6
  3. Drakesmith, Alexander. "Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease.". Nature communications (2019): https://europepmc.org/articles/PMC6778199.
    10.1038/s41467-019-12296-1
  4. Drakesmith, Alexander. "Minihepcidins improve ineffective erythropoiesis and splenomegaly in a new mouse model of adult beta-thalassemia major.". Haematologica (2019): https://doi.org/10.3324/haematol.2018.212589.
    10.3324/haematol.2018.212589
  5. Drakesmith, Alexander. "Twenty Years of Ferroportin Disease: A Review or An Update of Published Clinical, Biochemical, Molecular, and Functional Features.". Pharmaceuticals (Basel, Switzerland) (2019): https://europepmc.org/articles/PMC6789780.
    10.3390/ph12030132
  6. Andrew E. Armitage; Hal Drakesmith. "The diagnostic potential of the iron-regulatory hormone hepcidin". HemaSphere 3 (2019): 100-103. https://doi.org/10.1097%2Fhs9.0000000000000236.
    10.1097/hs9.0000000000000236
  7. Drakesmith, Alexander. "Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.". Nature metabolism (2019): https://europepmc.org/articles/PMC6609153.
    10.1038/s42255-019-0063-6
  8. Drakesmith, Alexander. "Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children.". Science Advances (2019): https://europepmc.org/articles/PMC6436921.
    10.1126/sciadv.aav9020
  9. S.R. Pasricha; H. Drakesmith. "Hemoglobinopathies in the Fetal Position". Obstetric Anesthesia Digest 39 1 (2019): 45-45. https://doi.org/10.1097%2F01.aoa.0000552920.81566.05.
    10.1097/01.aoa.0000552920.81566.05
  10. Drakesmith, Alexander. "Rapid growth is a dominant predictor of hepcidin suppression and declining ferritin in Gambian infants.". Haematologica (2019): https://europepmc.org/articles/PMC6669141.
    10.3324/haematol.2018.210146
  11. Drakesmith, Alexander. "Antiviral activity of bone morphogenetic proteins and activins.". Nature microbiology (2018): https://europepmc.org/articles/PMC6590058.
    10.1038/s41564-018-0301-9
  12. Drakesmith, Alexander. "Erythroferrone inhibits the induction of hepcidin by BMP6.". Blood (2018): https://europepmc.org/articles/PMC6238155.
    10.1182/blood-2018-06-857995
  13. Drakesmith, Alexander. "Reducing anaemia in low income countries: control of infection is essential.". BMJ (Clinical research ed.) (2018): https://doi.org/10.1136/bmj.k3165.
    10.1136/bmj.k3165
  14. Sunil Bhandari; Dora Pereira; Helen Chappell; Hal Drakesmith. "Intravenous Irons: From Basic Science to Clinical Practice". Pharmaceuticals 11 3 (2018): 82-82. https://doi.org/10.3390%2Fph11030082.
    10.3390/ph11030082
  15. Drakesmith, Alexander. "Serum hepcidin potentially identifies iron deficiency in survivors of critical illness at the time of hospital discharge.". British journal of haematology (2018): https://doi.org/10.1111/bjh.15067.
    10.1111/bjh.15067
  16. Drakesmith, Alexander. "Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.". Nature communications (2017): https://europepmc.org/articles/PMC5581335.
    10.1038/s41467-017-00500-z
  17. Hal Drakesmith; Stephen J Allen. "Improving iron supplements: cooking with GOS". Gut 66 11 (2017): 1881-1882. https://doi.org/10.1136%2Fgutjnl-2017-314593.
    10.1136/gutjnl-2017-314593
  18. Drakesmith, Alexander. "Hepatic iron is the major determinant of serum ferritin in NAFLD patients.". Liver international : official journal of the International Association for the Study of the Liver (2017): https://doi.org/10.1111/liv.13513.
    10.1111/liv.13513
  19. Drakesmith, Alexander. "Short-Term versus Long-Term Blood Storage.". The New England journal of medicine (2017): https://doi.org/10.1056/NEJMc1700464.
    10.1056/nejmc1700464
  20. Drakesmith, Alexander. "Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia.". Journal of innate immunity (2016): https://europepmc.org/articles/PMC5322583.
    10.1159/000447713
  21. Drakesmith, Alexander. "Regulation of Hepcidin by Erythropoiesis: The Story So Far.". Annual review of nutrition (2016): https://doi.org/10.1146/annurev-nutr-071715-050731.
    10.1146/annurev-nutr-071715-050731
  22. Sant-Rayn Pasricha; Hal Drakesmith. "Iron Deficiency Anemia". Hematology/Oncology Clinics of North America 30 2 (2016): 309-325. https://doi.org/10.1016%2Fj.hoc.2015.11.003.
    10.1016/j.hoc.2015.11.003
  23. Hal Drakesmith; Elizabeta Nemeth; Tomas Ganz. "Ironing out Ferroportin". Cell Metabolism 22 5 (2015): 777-787. https://doi.org/10.1016%2Fj.cmet.2015.09.006.
    10.1016/j.cmet.2015.09.006
  24. Drakesmith, Alexander. "Hepcidin is suppressed by erythropoiesis in hemoglobin E ß-thalassemia and ß-thalassemia trait.". Blood (2014): https://europepmc.org/articles/PMC4321326.
    10.1182/blood-2014-10-606491
  25. Drakesmith, Alexander. "Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections.". Proceedings of the National Academy of Sciences of the United States of America (2014): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25092293/?tool=EBI.
    10.1073/pnas.1402351111
  26. Drakesmith, Alexander. "Expression of the iron hormone hepcidin distinguishes different types of anemia in African children.". Science translational medicine (2014): https://doi.org/10.1126/scitranslmed.3008249.
    10.1126/scitranslmed.3008249
  27. Natasha Spottiswoode; Patrick E. Duffy; Hal Drakesmith. "Iron, anemia and hepcidin in malaria". Frontiers in Pharmacology 5 (2014): https://doi.org/10.3389%2Ffphar.2014.00125.
    10.3389/fphar.2014.00125
  28. Drakesmith, Alexander. "Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children.". Blood (2014): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24596418/?tool=EBI.
    10.1182/blood-2013-10-533000
  29. Hal Drakesmith. "Hepcidin at the Nexus of Infection and Anemia". Blood 124 21 (2014): SCI--39--SCI--39-SCI--39--SCI--39. https://doi.org/10.1182%2Fblood.v124.21.sci-39.sci-39.
    10.1182/blood.v124.21.sci-39.sci-39
  30. A. E. Armitage; H. Drakesmith. "The battle for iron". Science 346 6215 (2014): 1299-1300. https://doi.org/10.1126%2Fscience.aaa2468.
    10.1126/science.aaa2468
  31. H. Drakesmith; A. M. Prentice. "Hepcidin and the Iron-Infection Axis". Science 338 6108 (2012): 768-772. https://doi.org/10.1126%2Fscience.1224577.
    10.1126/science.1224577
  32. Drakesmith, Alexander. "Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children.". Blood (2012): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22228627/?tool=EBI.
    10.1182/blood-2011-11-391219
  33. Drakesmith, Alexander. "Hepcidin regulation by innate immune and infectious stimuli.". Blood (2011): https://doi.org/10.1182/blood-2011-04-351957.
    10.1182/blood-2011-04-351957
  34. Drakesmith, Alexander. "Host-mediated regulation of superinfection in malaria.". Nature medicine (2011): https://europepmc.org/articles/PMC4200394.
    10.1038/nm.2368
  35. Hal Drakesmith; Andrew Prentice. "Viral infection and iron metabolism". Nature Reviews Microbiology 6 7 (2008): 541-552. https://doi.org/10.1038%2Fnrmicro1930.
    10.1038/nrmicro1930
  36. Kathryn J.H. Robson; Hal Drakesmith. "Multifactorial Iron Man". Digestion 72 1 (2005): 22-24. https://doi.org/10.1159%2F000087399.
    10.1159/000087399
  37. Drakesmith, Alexander. "HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.". Proceedings of the National Academy of Sciences of the United States of America (2005): https://europepmc.org/articles/PMC1180511.
    10.1073/pnas.0504823102
  38. Drakesmith, Alexander. "Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin.". Blood (2005): https://doi.org/10.1182/blood-2005-02-0561.
    10.1182/blood-2005-02-0561
  39. Drakesmith, Alexander. "In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations.". Blood (2005): https://doi.org/10.1182/blood-2004-11-4502.
    10.1182/blood-2004-11-4502
  40. Drakesmith, Alexander. "The hemochromatosis protein HFE inhibits iron export from macrophages.". Proceedings of the National Academy of Sciences of the United States of America (2002): https://europepmc.org/articles/PMC137763.
    10.1073/pnas.242614699
  41. Drakesmith, Alexander. "Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload.". Lancet (London, England) (2002): https://doi.org/10.1016/S0140-6736(02)07885-6.
    10.1016/s0140-6736(02)07885-6
  42. Hal Drakesmith; Alain Townsend. "The structure and function of HFE". BioEssays 22 7 (2000): 595-598. https://doi.org/10.1002%2F1521-1878%28200007%2922%3A7%3C595%3A%3Aaid-bies1%3E3.0.co%3B2-e.
    10.1002/1521-1878(200007)22:7<595::aid-bies1>3.0.co;2-e
  43. Hal Drakesmith; Benjamin Chain; Peter Beverley. "How can dendritic cells cause autoimmune disease?". Immunology Today 21 5 (2000): 214-217. https://doi.org/10.1016%2Fs0167-5699%2800%2901610-8.
    10.1016/s0167-5699(00)01610-8
  44. Drakesmith, Alexander. "In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen.". Proceedings of the National Academy of Sciences of the United States of America (1998): https://europepmc.org/articles/PMC24548.
    10.1073/pnas.95.25.14903

Outros

Outra produção
  1. Iron, Immunity, and Infection. 2017. Hal Drakesmith. https://doi.org/10.1201%2F9781315118901-13.
    10.1201/9781315118901-13
  2. Iron and the Immune System. 2011. Hal Drakesmith; Graça Porto; Maria de Sousa. https://doi.org/10.1007%2F978-1-60327-485-2_12.
    10.1007/978-1-60327-485-2_12