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Manuel Vilanova currently is Full Professor of Immunology and Vice-Dean at ICBAS - School of Medicine and Biomedical Sciences of Universidade do Porto. At ICBAS MV coordinates curricular units in the fields of immunology and infection and currently directs the PhD programme on Molecular and Cellular Biotechnology Applied to Health Sciences (BiotechHealth). MV graduated in Biochemistry by U.Porto in 1988 and joined the Laboratory of Immunology at ICBAS in 1989, working under the supervision of Prof. Mário Arala Chaves. MV defended the PhD thesis in Biomedical Sciences at ICBAS in 1999. He was PI in 5 funded projects and participated as co-PI/team member in > 20 other funded projects, mainly in the areas of immunology and infection. MV supervised/co-supervised circa 30 PhD students, and 5 post-docs. He authored/co-authored > 120 research articles published in international peer-reviewed journals, and book chapters and patents, mainly in the fields of immunology, infection and microbiology. His studies particularly addressed immunobiological mechanisms operating in hosts infected with patogens with high impact in human or animal health, such as Staphylococcus epidermidis, Candida albicans, and Neospora caninum. He is/was Editorial Board member in international scientific journals, including "Carbohydrate Polymers" and "Scientific Reports". Manuel Vilanova directs since 2005 the Immunobiology group of Instituto de Biologia Molecular e Celular (IBMC) at Porto, now integrating the Instituto de Inovação e Investigação em Saúde (I3S) of U.Porto. He presided the Portuguese Society for Immunology in 2012-2015.
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Identificação

Identificação pessoal

Nome completo
Manuel Vilanova

Identificadores de autor

Ciência ID
681E-3435-C7F8
ORCID iD
0000-0001-7007-306X
Researcher Id
D-2127-2013
Scopus Author Id
7004113667

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
Formação
Grau Classificação
1999/06/25
Concluído
 Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
1983 - 1988
Concluído
 Biochemistry (Licenciatura)
Universidade do Porto, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - Atual Investigador (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/01/16 - Atual Professor Catedrático (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Projetos

Projeto

Designação Financiadores
2022/01/01 - 2024/12/31 Combined mucosal and systemic immunization to protect against bovine neosporosis
PTDC/CVT-CVT/3045/2021
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2020/10/01 - 2023/09/30 HEALTH-UNORTE: Setting-up biobanks and regenerative medicine strategies to boost research in cardiovascular, musculoskeletal, neurological, oncological, immunological and infectious diseases
NORTE-01-0145-FEDER-000039
Responsible Investigator at ICBAS
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Concluído
2022/01/01 - 2023/06/30 Meningeal Immunity and NeuroInflammation: deciphering the immune cells intervening in neonatal bacterial meningitis
EXPL/SAU-INF/1217/2021
Investigador
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2021/01/01 - 2023/06/30 MARemPó
POCI-01-0247-FEDER-047200
ALG-01-0247-FEDER-047200
Investigador
Concluído
2021/01/01 - 2023/06/30 BUGS@PETS - Development of new insect ingredients for incorporation into complete compound foods for pets
POCI-01-0247-FEDER-047042
Investigador
Concluído
2019/01/01 - 2022/12/31 ALGAVALOR – MicroALGAs: produção integrada e VALORização da biomassa e das suas diversas aplicações
POCI-01-0247-FEDER-035234
LISBOA-01-0247-FEDER-035234
ALG-01-0247-FEDER-035234
Investigador
Concluído
2018/09/01 - 2021/08/31 Valuation of brewers spent yeast polysaccharides for food and biomedical applications
PTDC/BAA-AGR/30936/2017
Investigador
Universidade de Aveiro, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/07/26 - 2021/07/25 Dietary polyphenols as prophylactic agents in food allergies
PTDC/SAU-NUT/30448/2017
Investigador
Universidade do Porto Faculdade de Ciências, Portugal
Concluído
2018/07/01 - 2021/06/30 Impact of S. epidermidis dormancy and persistence in host pathogenesis
PTDC/BIA-MOL/29553/2017
Investigador responsável
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/07/01 - 2021/06/30 Dietary Polyphenol's Role in the Prevention of Celiac Disease
PTDC/OCE-ETA/32287/2017
Investigador
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/06/01 - 2021/05/31 Development of an experimental vaccine against neosporosis in cattle
PTDC/CVT-CVT/31020/2017
Investigador
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/06/01 - 2021/05/31 Glycans in autoimmunity. Impact in Systemic Lupus Erythematosus pathogenesis and treatment.
PTDC/MEC-REU/28772/2017
Investigador
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/12/01 - 2019/12/01 MinDog - organic minerals in dog feeding
POCI-01-0247-FEDER-017616
Investigador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Agência Nacional de Inovação SA
Concluído
2016/07/01 - 2019/07/01 Glycans as novel immunomodulators in Inflammatory Bowel Disease: an opportunity for new therapeutic strategies.
PTDC/DTP-PIC/0560/2014
Investigador
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/07/01 - 2019/06/30 Study of the immune function of adipose tissue in Neospora caninum infected hosts.
PTDC/CVT-WEL/3079/2014
POCI-01-0145-FEDER-016732
POCI-01-0145-FEDER-016732
Investigador
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluído
2016/05/01 - 2019/04/30 Structured program on bioengineered therapies for infectious diseases and tissue regeneration.
Norte-01-0145-FEDER-000012.
Investigador
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 European Regional Development Fund
Concluído
2014/03/01 - 2015/08/01 Transcriptomic analysis of biofilm-released Staphylococcus epidermidis cells response to human blood components.
EXPL/BIA-MIC/0101/2013
Investigador
Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluído
2014/01/01 - 2015/06/16 Seaweeds in Ruminant Feeding
EXPL/CVT-NUT/0286/2013
Investigador
European Regional Development Fund

Fundação para a Ciência e a Tecnologia
Concluído
2013/12/01 - 2014/12/01 T cell receptor N-glycosylation as a new mechanism underlying Inflammatory Bowel Disease pathogenesis. Implications for therapy
EXPL/BIM-MEC/0149/2012
Investigador
Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluído
2011/01/01 - 2013/12/31 Molecular interactions between S. epidermidis biofilm cells and the murine host response
PTDC/BIAMIC/113450/2009
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2013/09/01 Study of the immune response and protective effect against neosporosis elicited by mucosal immunization with Neospora caninum antigens.
PTDC/CVT/115126/2009
Investigador responsável
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009/03/04 - 2011/12/31 IMMUNONET-Network on immunotherapy
SUDOE-FEDERIMMUNONETSOE1/P1/E014
Investigador responsável
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Concluído
2005/06/01 - 2008/05/31 Immunobiological studies of secreted aspartic proteases secreted by Candida albicans and their usage as target antigens against systemic candidiasis.
POCTI/SAU/IMI/58014/2004
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2002/11/02 - 2006/09/01 Immunobiological studies in murine models of Neospora caninum infection towards the development of new vaccination approaches
info:eu-repo/grantAgreement/FCT/POCI/38795/PT
Investigador responsável
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluído
2001/04/01 - 2005/08/15 Immunobiological studies of microbial virulence immunomodulatory proteins that allow the survival of the secreting microorganism in the host.
POCTI/MGI/33570/99
Investigador responsável
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Fundação para a Ciência e a Tecnologia

European Regional Development Fund
Concluído
Produções

Publicações

Artigo em revista
  1. Oliveira, Bárbara M.; Sidónio, Beatriz; Correia, Alexandra; Pinto, Ana; Azevedo, Maria M.; Sampaio, Paula; Ferreira, Paula G.; Vilanova, Manuel; Teixeira, Luzia. "Cytokine production by bovine adipose tissue stromal vascular fraction cells upon Neospora caninum stimulation". Scientific Reports 14 1 (2024): http://dx.doi.org/10.1038/s41598-024-58885-z.
    10.1038/s41598-024-58885-z
  2. Rui M. Gil da Costa; Christine Levesque; Daniella Bianchi-Frias; Payel Chatterjee; Hung-Ming Lam; Carlos Santos; Ilsa M. Coleman; et al. "Pharmacological NF-¿B inhibition decreases cisplatin chemoresistance in muscle-invasive bladder cancer and reduces cisplatin-induced toxicities.". Molecular Oncology (2023): https://doi.org/10.1002/1878-0261.13504.
    10.1002/1878-0261.13504
  3. Costa-Barbosa, Augusto; Pacheco, Maria Inês; Carneiro, Catarina; Botelho, Cláudia; Gomes, Andreia C.; Real Oliveira, M. Elisabete C.D.; Collins, Tony; et al. "Design of a lipid nano-delivery system containing recombinant Candida albicans chitinase 3 as a potential vaccine against fungal infections". Biomedicine & Pharmacotherapy 166 (2023): 115362. http://dx.doi.org/10.1016/j.biopha.2023.115362.
    10.1016/j.biopha.2023.115362
  4. Iris Caramalho; Maria Strecht Almeida; Manuel Vilanova; Carlos Penha-Gonçalves. "Portuguese Society of Immunology (SPI): Turning 50, inspired by the past, looking into the future". European Journal of Immunology (2023): https://doi.org/10.1002/eji.202350570.
    10.1002/eji.202350570
  5. Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; et al. "Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity". Cellular & Molecular Immunology 20 8 (2023): 955-968. http://dx.doi.org/10.1038/s41423-023-01052-7.
    10.1038/s41423-023-01052-7
  6. Moreira, Ana S. P.; Gaspar, Diana; Ferreira, Sónia S.; Correia, Alexandra; Vilanova, Manuel; Perrineau, Marie-Mathilde; Kerrison, Philip D.; et al. "Water-Soluble Saccharina latissima Polysaccharides and Relation of Their Structural Characteristics with In Vitro Immunostimulatory and Hypocholesterolemic Activities". Marine Drugs 21 3 (2023): 183. http://dx.doi.org/10.3390/md21030183.
    10.3390/md21030183
  7. Sónia S. Ferreira; Alexandra Correia; Artur M.S. Silva; Dulcineia Ferreira Wessel; Susana M. Cardoso; Manuel Vilanova; Manuel A. Coimbra. "Structure-function relationships of pectic polysaccharides from broccoli by-products with in vitro B lymphocyte stimulatory activity". Carbohydrate Polymers 303 (2023): 120432-120432. http://dx.doi.org/10.1016/j.carbpol.2022.120432.
    10.1016/j.carbpol.2022.120432
  8. Reis, Sofia F.; Martins, Vitor J.; Bastos, Rita; Lima, Tânia; Correia, Viviana G.; Pinheiro, Benedita A.; Silva, Lisete M.; et al. "Feasibility of Brewer’s Spent Yeast Microcapsules as Targeted Oral Carriers". Foods 12 2 (2023): 246. http://dx.doi.org/10.3390/foods12020246.
    10.3390/foods12020246
  9. Ferreira, Catarina M.; Micheli, Consuelo; Barreira-Silva, Palmira; Barbosa, Ana Margarida; Resende, Mariana; Vilanova, Manuel; Silvestre, Ricardo; et al. "IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.946181.
    10.3389/fimmu.2022.946181
  10. Tânia Lima; Stefán B. Gunnarsson; Elisabete Coelho; Dmitry V. Evtuguin; Alexandra Correia; Manuel A. Coimbra; Tommy Cedervall; Manuel Vilanova. "ß-Glucan-Functionalized Nanoparticles Down-Modulate the Proinflammatory Response of Mononuclear Phagocytes Challenged with Candida albicans". Nanomaterials (2022): https://doi.org/10.3390/nano12142475.
    10.3390/nano12142475
  11. Alexandra Correia; Pedro Alves; Ricardo Fróis-Martins; Luzia Teixeira; Manuel Vilanova. "Protective Effect against Neosporosis Induced by Intranasal Immunization with Neospora caninum Membrane Antigens Plus Carbomer-Based Adjuvant". Vaccines (2022): https://doi.org/10.3390/vaccines10060925.
    10.3390/vaccines10060925
  12. Hamed, Mariem; Coelho, Elisabete; Bastos, Rita; Evtuguin, Dmitry V.; Ferreira, Sónia S.; Lima, Tânia; Vilanova, Manuel; et al. "Isolation and identification of an arabinogalactan extracted from pistachio external hull: Assessment of immunostimulatory activity". Food Chemistry 373 (2022): 131416. http://dx.doi.org/10.1016/j.foodchem.2021.131416.
    10.1016/j.foodchem.2021.131416
  13. Fernando Oliveira; Tânia Lima; Alexandra Correia; Ana Margarida Silva; Cristina Soares; Simone Morais; Samira Weißelberg; et al. "Involvement of the Iron-Regulated Loci hts and fhuC in Biofilm Formation and Survival of Staphylococcus epidermidis within the Host". Microbiology Spectrum (2022): https://doi.org/10.1128/spectrum.02168-21.
    10.1128/spectrum.02168-21
  14. Gaio, Vania; Lima, Tania; Vilanova, Manuel; Cerca, Nuno; Franca, Angela. "mazEF Homologue Has a Minor Role in Staphylococcus epidermidis 1457 Virulence Potential". Frontiers in Cellular and Infection Microbiology (2022): https://publons.com/wos-op/publon/51192681/.
    10.3389/FCIMB.2021.803134
  15. Oliveira, Fernando; Lima, Tânia; Correia, Alexandra; Silva, Ana Margarida; Soares, Cristina; Morais, Simone; Weißelberg, Samira; et al. "Siderophore-Mediated Iron Acquisition Plays a Critical Role in Biofilm Formation and Survival of Staphylococcus epidermidis Within the Host". Frontiers in Medicine 8 (2021): http://dx.doi.org/10.3389/fmed.2021.799227.
    10.3389/fmed.2021.799227
  16. Oliveira, Fernando; Rohde, Holger; Vilanova, Manuel; Cerca, Nuno. "Fighting Staphylococcus epidermidis Biofilm-Associated Infections: Can Iron Be the Key to Success?". Frontiers in Cellular and Infection Microbiology 11 (2021): http://dx.doi.org/10.3389/fcimb.2021.798563.
    10.3389/fcimb.2021.798563
  17. Oliveira, Fernando; Rohde, Holger; Vilanova, Manuel; Cerca, Nuno. "The Emerging Role of Iron Acquisition in Biofilm-Associated Infections". Trends in Microbiology (2021): http://dx.doi.org/10.1016/j.tim.2021.02.009.
    10.1016/j.tim.2021.02.009
  18. Barros, Mariana; Teixeira, Daniela; Vilanova, Manuel; Correia, Alexandra; Teixeira, Natercia; Borges, Margarida. "Vaccines in Congenital Toxoplasmosis: Advances and Perspectives". Frontiers in Immunology 11 (2021): http://dx.doi.org/10.3389/fimmu.2020.621997.
    Acesso aberto • Publicado • 10.3389/fimmu.2020.621997
  19. Ferreira, Andreia S.; Mendonca, Ines; Povoa, Ines; Carvalho, Helia; Correia, Alexandra; Vilanova, Manuel; Silva, Tiago H.; Coimbra, Manuel A.; Nunes, Claudia. "Impact of growth medium salinity on galactoxylan exopolysaccharides of Porphyridium purpureum". Algal Research (2021): https://publons.com/wos-op/publon/49537052/.
    10.1016/J.ALGAL.2021.102439
  20. Pedro, Ana R. V.; Lima, Tania; Frois-Martins, Ricardo; Leal, Barbara; Ramos, Isabel C.; Martins, Elisabete G.; Cabrita, Ana R. J.; et al. "Dectin-1-Mediated Production of Pro-Inflammatory Cytokines Induced by Yeast beta-Glucans in Bovine Monocytes". Frontiers in Immunology (2021): https://publons.com/wos-op/publon/46883768/.
    10.3389/FIMMU.2021.689879
  21. Silva, Mariana C.; Fernandes, Ângela; Oliveira, Maria; Resende, Carlos; Correia, Alexandra; de-Freitas-Junior, Julio C.; Lavelle, Aonghus; et al. "Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression". Cancer Immunology Research 8 11 (2020): 1407-1425. http://dx.doi.org/10.1158/2326-6066.cir-20-0264.
    10.1158/2326-6066.cir-20-0264
  22. Teixeira, Luzia; Correia, Alexandra; Oliveira, Bárbara M.; Pinto, Ana; Ferreira, Paula G.; Vilanova, Manuel. "Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum". Pathogens 9 7 (2020): 587. http://dx.doi.org/10.3390/pathogens9070587.
    10.3390/pathogens9070587
  23. Pereira, Ana Margarida; Guedes, Margarida; Matos, Elisabete; Pinto, Edgar; Almeida, Agostinho A.; Segundo, Marcela A.; Correia, Alexandra; et al. "Effect of Zinc Source and Exogenous Enzymes Supplementation on Zinc Status in Dogs Fed High Phytate Diets". Animals 10 3 (2020): 400. http://dx.doi.org/10.3390/ani10030400.
    10.3390/ani10030400
  24. Cabral, Maria P.; Correia, Alexandra; Vilanova, Manuel; Gärtner, Fátima; Moscoso, Miriam; García, Patricia; Vallejo, Juan A.; et al. "A live auxotrophic vaccine confers mucosal immunity and protection against lethal pneumonia caused by Pseudomonas aeruginosa". PLOS Pathogens 16 2 (2020): e1008311. http://dx.doi.org/10.1371/journal.ppat.1008311.
    10.1371/journal.ppat.1008311
  25. Oliveira, Bárbara M.; Pinto, Ana; Correia, Alexandra; Ferreira, Paula G.; Vilanova, Manuel; Teixeira, Luzia. "Characterization of Myeloid Cellular Populations in Mesenteric and Subcutaneous Adipose Tissue of Holstein-Friesian Cows". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-58678-0.
    10.1038/s41598-020-58678-0
  26. Lima, Tânia; Bernfur, Katja; Vilanova, Manuel; Cedervall, Tommy. "Understanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-57943-6.
    10.1038/s41598-020-57943-6
  27. Ferreira, Andreia S.; Ferreira, Sónia S.; Correia, Alexandra; Vilanova, Manuel; Silva, Tiago H.; Coimbra, Manuel A.; Nunes, Cláudia. "Reserve, structural and extracellular polysaccharides of Chlorella vulgaris: A holistic approach". Algal Research 45 (2020): 101757. http://dx.doi.org/10.1016/j.algal.2019.101757.
    10.1016/j.algal.2019.101757
  28. Pandeirada, Carolina O.; Maricato, Élia; Ferreira, Sónia S.; Correia, Viviana G.; Pinheiro, Benedita A.; Evtuguin, Dmitry V.; Palma, Angelina S.; et al. "Structural analysis and potential immunostimulatory activity of Nannochloropsis oculata polysaccharides". Carbohydrate Polymers 222 (2019): 114962. http://dx.doi.org/10.1016/j.carbpol.2019.06.001.
    10.1016/j.carbpol.2019.06.001
  29. Nunes, Cláudia; Rocha, Ana; Quitério, Pedro; Ferreira, Sónia S.; Correia, Alexandra; Vilanova, Manuel; Coimbra, Manuel A.. "Salt pan brine water as a sustainable source of sulphated polysaccharides with immunostimulatory activity". International Journal of Biological Macromolecules 133 (2019): 235-242. http://dx.doi.org/10.1016/j.ijbiomac.2019.04.021.
    10.1016/j.ijbiomac.2019.04.021
  30. Oliveira, Bárbara M.; Rasteiro, Ana M.; Correia, Alexandra; Pinto, Ana; Meireles, Pedro; Ferreira, Paula G.; Vilanova, Manuel; Teixeira, Luzia. "T cells in mesenteric and subcutaneous adipose tissue of Holstein-Friesian cows". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-39938-0.
    10.1038/s41598-019-39938-0
  31. Rodrigues, Célia; Correia, Alexandra; Vilanova, Manuel; Henriques, Mariana. "Inflammatory Cell Recruitment in Candida glabrata Biofilm Cell-Infected Mice Receiving Antifungal Chemotherapy". Journal of Clinical Medicine 8 2 (2019): 142. http://dx.doi.org/10.3390/jcm8020142.
    10.3390/jcm8020142
  32. Silva-Carvalho, Ricardo; Silva, João P.; Ferreirinha, Pedro; Leitão, Alexandre F.; Andrade, Fábia K.; da Costa, Rui M. Gil; Cristelo, Cecília; et al. "Inhalation of Bacterial Cellulose Nanofibrils Triggers an Inflammatory Response and Changes Lung Tissue Morphology of Mice". Toxicological Research 35 1 (2019): 45-63. http://dx.doi.org/10.5487/tr.2019.35.1.045.
    10.5487/tr.2019.35.1.045
  33. Correia, Ana; Silva, Dany; Correia, Alexandra; Vilanova, Manuel; Gärtner, Fátima; Vale, Nuno. "Study of New Therapeutic Strategies to Combat Breast Cancer Using Drug Combinations". Biomolecules 8 4 (2018): 175. http://dx.doi.org/10.3390/biom8040175.
    10.3390/biom8040175
  34. Ferreirinha, Pedro; Fróis-Martins, Ricardo; Teixeira, Luzia; Rocha, António; Vilanova, Manuel; Correia, Alexandra. "Interferon-¿-dependent protection against Neospora caninum infection conferred by mucosal immunization in IL-12/IL-23 p40-deficient mice". Vaccine 36 32 (2018): 4890-4896. http://dx.doi.org/10.1016/j.vaccine.2018.06.060.
    10.1016/j.vaccine.2018.06.060
  35. Furtado, José M.; Almeida, Sílvia M.; Mascarenhas, Paulo; Ferraz, Maria E.; Ferreira, José C.; Vilanova, Manuel; Monteiro, Mariana P.; Ferraz, Fernando P.. "Anthropometric features as predictors of atherogenic dyslipidemia and cardiovascular risk in a large population of school-aged children". PLOS ONE 13 6 (2018): e0197922. http://dx.doi.org/10.1371/journal.pone.0197922.
    10.1371/journal.pone.0197922
  36. Dias, Ana M.; Correia, Alexandra; Pereira, Márcia S.; Almeida, Catarina R.; Alves, Inês; Pinto, Vanda; Catarino, Telmo A.; et al. "Metabolic control of T cell immune response through glycans in inflammatory bowel disease". Proceedings of the National Academy of Sciences 115 20 (2018): E4651-E4660. http://dx.doi.org/10.1073/pnas.1720409115.
    10.1073/pnas.1720409115
  37. Almeida, Sílvia M.; Furtado, José M.; Mascarenhas, Paulo; Ferraz, Maria E.; Ferreira, José C.; Monteiro, Mariana P.; Vilanova, Manuel; Ferraz, Fernando P.. "Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children". Endocrine 60 3 (2018): 466-478. http://dx.doi.org/10.1007/s12020-018-1587-3.
    10.1007/s12020-018-1587-3
  38. Freitas, Ana I; Lopes, Nathalie; Oliveira, Fernando; Brás, Susana; França, Ângela; Vasconcelos, Carlos; Vilanova, Manuel; Cerca, Nuno. "Comparative analysis between biofilm formation and gene expression in Staphylococcus epidermidis isolates". Future Microbiology 13 4 (2018): 415-427. http://dx.doi.org/10.2217/fmb-2017-0140.
    10.2217/fmb-2017-0140
  39. Ferreira, Sónia S.; Passos, Cláudia P.; Cepeda, Márcio R.; Lopes, Guido R.; Teixeira-Coelho, Maria; Madureira, Pedro; Nunes, Fernando M.; Vilanova, Manuel; Coimbra, Manuel A.. "Structural polymeric features that contribute to in vitro immunostimulatory activity of instant coffee". Food Chemistry 242 (2018): 548-554. http://dx.doi.org/10.1016/j.foodchem.2017.09.059.
    10.1016/j.foodchem.2017.09.059
  40. Sanfins, Elodie; Correia, Alexandra; B. Gunnarsson, Stefan; Vilanova, Manuel; Cedervall, Tommy. "Nanoparticle effect on neutrophil produced myeloperoxidase". PLOS ONE 13 1 (2018): e0191445. http://dx.doi.org/10.1371/journal.pone.0191445.
    10.1371/journal.pone.0191445
  41. Carvalhais, Virginia; Pérez-Cabezas, Begoña; Oliveira, Cátia; Vitorino, Rui; Vilanova, Manuel; Cerca, Nuno. "Tetracycline and rifampicin induced a viable but nonculturable state in Staphylococcus epidermidis biofilms". Future Microbiology 13 1 (2018): 27-36. http://dx.doi.org/10.2217/fmb-2017-0107.
    10.2217/fmb-2017-0107
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  104. TEIXEIRA, L.; BOTELHO, A. S.; BATISTA, A. R.; MEIRELES, C. S.; RIBEIRO, A.; DOMINGUES, H. S.; CORREIA DA COSTA, J. M.; et al. "Analysis of the immune response to Neospora caninum in a model of intragastric infection in mice". Parasite Immunology 29 1 (2007): 23-36. http://dx.doi.org/10.1111/j.1365-3024.2006.00911.x.
    10.1111/j.1365-3024.2006.00911.x
  105. Teixeira, Luzia; Marques, Andreia; Meireles, Carla Sofia; Seabra, Ana Rita; Rodrigues, Diana; Madureira, Pedro; Faustino, Augusto M. R.; et al. "Characterization of the B-cell immune response elicited in BALB/c mice challenged with Neospora caninum tachyzoites". Immunology 116 1 (2005): 38-52. http://dx.doi.org/10.1111/j.1365-2567.2005.02195.x.
    10.1111/j.1365-2567.2005.02195.x
  106. Cerca, Nuno; Pier, Gerald B.; Vilanova, Manuel; Oliveira, Rosário; Azeredo, Joana. "Quantitative analysis of adhesion and biofilm formation on hydrophilic and hydrophobic surfaces of clinical isolates of Staphylococcus epidermidis". Research in Microbiology 156 4 (2005): 506-514. http://dx.doi.org/10.1016/j.resmic.2005.01.007.
    10.1016/j.resmic.2005.01.007
  107. Cerca, N.; Pier, G.B.; Vilanova, M.; Oliveira, R.; Azeredo, J.. "Influence of batch or fed-batch growth on Staphylococcus epidermidis biofilm formation". Letters in Applied Microbiology 39 5 (2004): 420-424. http://dx.doi.org/10.1111/j.1472-765x.2004.01601.x.
    10.1111/j.1472-765x.2004.01601.x
  108. Dourado, Fernando; Madureira, Pedro; Carvalho, Vera; Coelho, Ricardo; Coimbra, Manuel A.; Vilanova, Manuel; Mota, Manuel; Gama, Francisco M.. "Purification, structure and immunobiological activity of an arabinan-rich pectic polysaccharide from the cell walls of Prunus dulcis seeds". Carbohydrate Research 339 15 (2004): 2555-2566. http://dx.doi.org/10.1016/j.carres.2004.07.024.
    10.1016/j.carres.2004.07.024
  109. Vilanova, Manuel; Teixeira, Luzia; Caramalho, Iris; Torrado, Egidio; Marques, Andreia; Madureira, Pedro; Ribeiro, Adilia; et al. "Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2". Immunology 111 3 (2004): 334-342. http://dx.doi.org/10.1111/j.1365-2567.2004.01819.x.
    10.1111/j.1365-2567.2004.01819.x
  110. Soares-da-Silva, I.M.; Ribeiro, J.; Valongo, C.; Pinto, R.; Vilanova, M.; Bleher, R.; Machado, J.. "Cytometric, morphologic and enzymatic characterisation of haemocytes in Anodonta cygnea". Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 132 3 (2002): 541-553. http://dx.doi.org/10.1016/s1095-6433(02)00039-9.
    10.1016/s1095-6433(02)00039-9
  111. VILANOVA; FERREIRA; RIBEIRO; ARALA-CHAVES. "The biological effects induced in mice by p36, a proteinaceous factor of virulence produced by African swine fever virus, are mediated by interleukin-4 and also to a lesser extent by interleukin-10". Immunology 96 3 (1999): 389-395. http://dx.doi.org/10.1046/j.1365-2567.1999.00629.x.
    10.1046/j.1365-2567.1999.00629.x
  112. Gama, F.M.; Vilanova, M.; Mota, M.. "Exo- and endo-glucanolytic activity of cellulases purified from Trichoderma reesei". Biotechnology Techniques 12 9 (1998): 677-681. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031709892&partnerID=MN8TOARS.
    10.1023/A:1008808803109
  113. Ferreira, P. "Purification, and biochemical and biological characterization of an immunosuppressive and lymphocyte mitogenic protein secreted by Streptococcus sobrinus". International Immunology 9 11 (1997): 1735-1743. http://dx.doi.org/10.1093/intimm/9.11.1735.
    10.1093/intimm/9.11.1735
  114. VILANOVA, M.; TAVARES, D.; FERREIRA, P.; OLIVEIRA, L.; NÓBREGA, A.; APPELBERG, R.; ARALA-CHAVES, M.. "Role of Monocytes in the Up-Regulation of the Early Activation Marker CD69 on B and T Murine Lymphocytes Induced by Microbial Mitogens". Scandinavian Journal of Immunology 43 2 (1996): 155-163. http://dx.doi.org/10.1046/j.1365-3083.1996.d01-25.x.
    10.1046/j.1365-3083.1996.d01-25.x
  115. Sequeira, T.; Vilanova, M.; Lobo-da-Cunha, A.; Baldaia, L.; Arala-Chaves, M.. "Flow Cytometric Analysis of Molt-Related Changes in Hemocyte Type in Male and Female Penaeus japonicus". The Biological Bulletin 189 3 (1995): 376-380. http://dx.doi.org/10.2307/1542156.
    10.2307/1542156
  116. Tavares, Delfina; Ferreira, Paula; Vilanova, Manuel; Videira, Arnaldo; Arala-Chaves, Mário. "Immunoprotection against systemic candidiasis in mice". International Immunology 7 5 (1995): 785-796. http://dx.doi.org/10.1093/intimm/7.5.785.
    10.1093/intimm/7.5.785
  117. ARALA-CHAVES, M.; VILANOVA, M.; RIBEIRO, A.; PINTO, J.. "I. Immunostimulatory Effect of Thalidomide in Normal C57BL/6 Mice is Compatible with Stimulation of a Highly Connected Central Immune System". Scandinavian Journal of Immunology 40 5 (1994): 535-542. http://dx.doi.org/10.1111/j.1365-3083.1994.tb03501.x.
    10.1111/j.1365-3083.1994.tb03501.x
  118. VILANOVA, M.; RIBEIRO, A.; CARNEIRO, J.; ARALA-CHAVES, M.. "II. The Effects of Thalidomide Treatment on Autoimmune-Prone NZB and MRL Mice are Consistent with Stimulation of the Central Immune System". Scandinavian Journal of Immunology 40 5 (1994): 543-548. http://dx.doi.org/10.1111/j.1365-3083.1994.tb03502.x.
    10.1111/j.1365-3083.1994.tb03502.x
  119. Esaguy, Nair; águas, Artur P.; Vilanova, Manuel; Silva, Manuel T.. "Activation of Human Neutrophils by Phorbol Ester Decreases the Cytoplasm Compactness and the Lactoferrin Content of the Granulocytes". Journal of Leukocyte Biology 50 5 (1991): 444-452. http://dx.doi.org/10.1002/jlb.50.5.444.
    10.1002/jlb.50.5.444
  120. Ribelro, Adilia dos Santos; Arala-Chaves, Mário Passalaqua; Vilanova, Manuel; Porto, Maria Teresa; Coutinho, Antonio. "Role of B and T lymphocytes in the specific immunosuppression induced by a protein released by a protein monocytes infected with African swine fever virus". International Immunology 3 2 (1991): 165-174. http://dx.doi.org/10.1093/intimm/3.2.165.
    10.1093/intimm/3.2.165
  121. ARALACHAVES, MP; RIBEIRO, AD; VILANOVA, M; PORTO, MT; SANTAREM, MG; LIMA, M. "CORRELATION BETWEEN B-CELL MITOGENICITY AND IMMUNOSUPPRESSOR EFFECTS OF A PROTEIN RELEASED BY PORCINE MONOCYTES INFECTED WITH AFRICAN SWINE FEVER VIRUS". American Journal of Veterinary Research (1988): https://publons.com/wos-op/publon/6715576/.

Propriedade Intelectual

Patente
  1. Vilanova, Manuel; Maria Delfina da Conceição Tavares Gomes; Paula Maria das Neves Ferreira da Silva; António José de Meneses Moreira da Fonseca; António Manuel Silvério Cabrita. 2009. "Vaccine against dental caries based on virulence-associated immunomodulatory extracellular proteins produced by the cariogenic bacteria Streptococcus sobrinus and Streptococcus mutans". Estados Unidos.
    Expirada
  2. Ferreira, Paula; Vilanova, Manuel; Delfina Tavares; Trieu-Cuot, Patrick. 2008. "Vacina contra Streptococcus agalactiae usando como antigénio alvo a gliceraldeido-3-fosfato desidrogenase (GAPDH)" produzida pela bacteria ou na sua forma recombinante". Portugal.
    Retirada
  3. Vilanova, Manuel. 2007. "Vaccine against Streptococcus agalactiae infection using native or recombinant S. agalactiae glyceraldheide-3-phosphate dehydrogenase (GAPDH) as a target antigen”".
    Expirada
  4. Vilanova, Manuel; Ferreira, Paula; Tavares, Delfina. 2005. "Vacinas contra a cárie dentária à base de proteínas extracelulares e imunomoduladoras associadas à virulência, produzidas pelas bactérias cariogénicas Streptococcus sobrinus e Streptococcus mutans". Portugal.
    Expirada

Outros

Outra produção
  1. Candida albicans: Clinical Relevance, Pathogenesis, and Host Immunity. 2015. Correia, Alexandra; Sampaio, Paula; Vilanova, Manuel; Pais, Célia. http://dx.doi.org/10.1002/9781118644843.ch50.
    10.1002/9781118644843.ch50
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/01/01 - Atual Development and assessment of a liposome-based vaccine against bovine neosporosis
Coorientador
 Veterinary Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2023/12/06 The role of codY and pdhA in S. epidermidis biofilms dormancy, antimicrobial tolerance and survival in the host
Coorientador
Universidade do Minho Escola de Engenharia, Portugal
2017/01/01 - 2023/09/04 Improving immune function in newborn calves through milk replacer and starter supplementation.
Coorientador
 PhD in Animal Science - SANFEED (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018/09/06 - 2023/05/10 Dynamics and functions of N-glycans in T cell development
Coorientador
 Immunology (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2022/05/25 S. epidermidis putative toxin-antitoxin module mazEF: role in VBNC formation and impact on the immune system
Coorientador
 Biomedical Engineering (Doutoramento)
Universidade do Minho, Portugal
2017/01/01 - 2020/02/27 Modulation of the host immune response to a human fungal pathogen using beta-glucan-functionalized nanoparticles
Orientador de Tânia Lima
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/01/01 - 2020 Prevalence of biomarkers for risk of cardiovascular disease in a child population with excess weight
Coorientador
 PhD in Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/12 - 2019/12/03 The role of iron uptake on Staphylococcus epidermidis biofilm formation and virulence.
Coorientador
 PhD in Bioengeneering
Universidade do Minho Escola de Engenharia, Portugal
2015 - 2018/05/22 Candida glabrata biofilms: mechanisms of antifungal resistance and matrix role
Coorientador
 PhD in Chemical and Biological Engineering (Doutoramento)
Universidade do Minho Escola de Engenharia, Portugal
2015/01 - 2018/05/03 Novel insights in IBD pathogenesis: T cell receptor N-glycosylation as a new molecular mechanism
Coorientador
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2016/12/13 Studies on immunity of freshwater bivalves (Unionidae family): characterization, applications as biomarker in toxic assays and antibacterial trials
Coorientador
 PhD in Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2016/04/19 Effect of modulating S. epidermidis biofilms dormancy in the biofilm physiology and host immune response
Coorientador
 PhD in Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2012/09 - 2016/03/22 Study of the immune response and protective effect against neosporosis elicited by mucosal immunization with Neospora caninum antigens.
Orientador
 Doutoramento em Ciências Veterinárias (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2015/07/13 The role and the prevalence of icaABDC, aap and bhp genes in the virulence of Staphylococcus epidermidis portuguese isolates
Coorientador
 PhD in Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2009/09 - 2013/12 Characterization of the molecular interactions between S. epidermidis biofilm infections and the host immune response
Coorientador
 PhD in Biomedical Engeneering (Doutoramento)
Universidade do Minho Escola de Engenharia, Portugal
2007 - 2012/12/21 Role of secreted aspartyl proteases in Candida albicans virulence, host immune response and immunoprotection in murine disseminated candidiasis
Coorientador de Alexandra Correia
 PhD in Sciences - Biology
Universidade do Minho Escola de Ciências, Portugal
2007 - 2012/07/16 Development of multifunctional mannan nanogel
Coorientador
 PhD in Biomedical Engeneering
Universidade do Minho Escola de Engenharia, Portugal
2006/03 - 2012/04 Modulation and analysis of the Staphylococcus epidermidis biofilm physiological state.
Orientador
 Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007/06 - 2010/12 Development of carrier systems for the controlled release of IL-10
Coorientador
 Chemical and Biological Engineering
Universidade do Minho Escola de Engenharia, Portugal
2006 - 2010 Immunobiological studies on a murine model of experimental Neospora caninum infection
Orientador
 Biology (Doutoramento)
Universidade de Vigo - Campus Lagoas Marcosende, Espanha
2006/03 - 2009/04/17 Serotyping of Toxoplasma Gondii - Contributions to the knowledge of parasite biodiversity.
Coorientador
 Doutoramento em Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Université de Limoges, França
2004/10 - 2008/05/12 Study of immunological mechanisms of resistance or susceptibility to experimental Neospora caninum infection in mice.
Orientador
 Biomedical Sciences (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018 - Atual Frontiers in Immunology (1664-3224) Frontiers Media SA
2018 - Atual Frontiers in Microbiology (1664-302X) Frontiers Media SA
2017/01 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2016/08 - Atual Carbohydrate Polymers Elsevier B.V.
2018 - 2019 Heliyon (2405-8440) Elsevier

Membro de associação

Nome da associação Tipo de participação
1989 - Atual Portuguese Society of Immunology Member
2015 - 2018 Portuguese Society of Immunology President of the General Assembly
2012 - 2015 Portuguese Society of Immunology President