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Diana Fontinha is currently a Senior Post-doctoral Researcher at the Prudêncio Lab of the Gulbenkian Institute for Molecular Medicine. She has concluded her PhD on Biomedical Sciences with a specialization in Microbiology and Parasitology in 2016 by the Faculty of Medicine, University of Lisbon, her MSc degree in Molecular Medical Microbiology in 2010 by the University of Nottingham, and her Bachelor's degree in Molecular Biology and Genetics in 2009 by the Faculty of Science, University of Lisbon. She has published 49 articles in peer-reviewed scientific journals, one of which as a senior co-corresponding author. She is an inventor in a patent, and has received 5 awards. During her academic path, she has worked with different host-pathogen interactions, comprising viruses and parasites. Her research interests focus on host-pathogen interactions, with particular emphasis on malaria. She is interested in the development of antimalarial strategies, particularly prophylactic options, including drugs, vaccine candidates and monoclonal antibodies. On the first topic, she has focused on the search and application of newly developed drugs, as well as on the repurposing of drugs that are employed in the management of communicable and non-communicable diseases, towards malaria. In this line of work, she has accompanied several MSc and PhD student internships on the screening of compounds against Plasmodium liver stage infection. She has further supervised two Master Thesis projects on drug repurposing and/or development against malaria parasites. She has been awarded an exploratory project by FCT to carry out the characterization of the antimalarial activity of ivermectin hybrids. Furthermore, she is interested in the development of new platforms for the study of this host-parasite interaction and on their application for evaluating novel compounds against Plasmodium liver stages. On the second topic, she is interested in the evaluation of novel vaccine candidates that can potentially confer protection against the neglected human malaria-causing parasite Plasmodium vivax, and is currently supervising a Master Thesis on that subject. Regarding the last topic, she is interested on the development and application of antimalarial monoclonal antibodies as prophylactic alternatives for specific target populations and was recently awarded an exploratory project by FCT to conduct research on this subject applied to Plasmodium vivax malaria. Furthermore, she is co-supervising a PhD Thesis on these last two topics towards a multifaceted approach to combatting Plasmodium vivax malaria.
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Identificação

Identificação pessoal

Nome completo
Diana Fontinha

Nomes de citação

  • Fontinha, Diana

Identificadores de autor

Ciência ID
6A17-C404-F33B
ORCID iD
0000-0002-0046-648X

Endereços de correio eletrónico

  • diana.fontinha@gimm.pt (Profissional)

Moradas

  • Gulbenkian Institute for Molecular Medicine. Av. Professor Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde - Parasitologia
  • Ciências Naturais - Ciências Biológicas - Virologia
  • Ciências Naturais - Ciências Biológicas
  • Ciências Naturais - Ciências Biológicas - Microbiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Formação
Grau Classificação
2016/09/19
Concluído
 PhD in Biomedical Sciences (Doutoramento)
Especialização em Microbiology and Parasitology
Universidade de Lisboa Faculdade de Medicina, Portugal
"MURID HERPESVIRUS-4 MODULATION OF B-T HELPER CELL INTERACTION" (TESE/DISSERTAÇÃO)
 Approved with distinction
2012
Concluído
 Laboratory Animal Science Course, Felasa Category B (Outros)
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2010
Concluído
 MSc in Molecular Medical Microbiology (Mestrado)
University of Nottingham, Reino Unido
"Identifying broadly-neutralising antibody specificities from Hepatitis C Virus infected patients" (TESE/DISSERTAÇÃO)
 74%
2009
Concluído
 Bachelor's in Genetics and Molecular Biology (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 16/20
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/10/01 - Atual Post-doctoral Researcher at MPrudêncio Lab Gulbenkian Institute for Molecular Medicine, Portugal
2016/10/01 - 2024/09/30 Post-doctoral Researcher at MPrudêncio Lab Instituto de Medicina Molecular, Portugal
2016/03/01 - 2016/09/01 Research Assistant at MPrudêncio Lab Instituto de Medicina Molecular, Portugal
2010/10/01 - 2011/09/01 Research Assistant at Viral Pathogenesis Unit (Professor Pedro Simas) Instituto de Medicina Molecular, Portugal
Projetos

Projeto

Designação Financiadores
2025/01/01 - Atual Targeting Plasmodium vivax malaria through monoclonal antibody development
2023.13987.PEX
Investigador responsável
Gulbenkian Institute for Molecular Medicine, Portugal
 Fundação para a Ciência e a Tecnologia
2023/01/01 - 2024/12/31 Ivermectin hybrids – potential insecticidal and multistage antiplasmodial drugs for malaria control
2022.02624.PTDC
10.54499/2022.02624.PTDC
Investigador responsável
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/09/01 - 2023/08/31 AMAZING - AMAZonian snake toxins: creatING value from bioresources
CIRCNA/BRB/0281/2019
Investigador
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/10/01 - 2021/09/30 A multitarget strategy to hit all stages of the Plasmodium life-cycle
PTDC/MED-QUI/30021/2017
Investigador
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018/07/01 - 2021/06/30 Enabling strategies for enhanced whole-sporozoite malaria vaccines
PTDC/SAU-INF/29550/2017
Investigador Pós-doutorado
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2018 - 2018 Production and maintenance of Plasmodium-infected mosquitoes
Pf
Investigador
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Merck Biopharma Deutschland
2016 - 2018 3D hepatic cell models of Plasmodium infection
3DHep
Investigador
Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Merck Biopharma Deutschland
Concluído
Produções

Publicações

Artigo em revista
  1. Parth; Santana S; Rôla C; Oliveira CB; Prudêncio M; Singh K; Fontinha D. "Antiplasmodial and Insecticidal Activities of Third-Generation Ivermectin Hybrids.". Journal of medicinal chemistry (2024): http://europepmc.org/abstract/med/39505355.
    10.1021/acs.jmedchem.4c01606
  2. Ferreira LT; Cassiano GC; Alvarez LCS; Okombo J; Calit J; Fontinha D; Gil-Iturbe E; et al. "A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.". PLoS pathogens (2024): http://europepmc.org/abstract/med/39471233.
    10.1371/journal.ppat.1012627
  3. Pavic K; Poje G; Pessanha de Carvalho L; Tandaric T; Marinovic M; Fontinha D; Held J; et al. "Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds.". Bioorganic & medicinal chemistry (2024): http://europepmc.org/abstract/med/38677112.
    10.1016/j.bmc.2024.117734
  4. Sulik M; Fontinha D; Steverding D; Sobczak S; Antoszczak M; Prudêncio M; Huczynski A. "Unexpected rearrangement of ivermectin in the synthesis of new derivatives with trypanocidal and antiplasmodial activities.". European journal of medicinal chemistry (2023): http://europepmc.org/abstract/med/37988797.
    10.1016/j.ejmech.2023.115951
  5. da Silva G; Luz AFS; Duarte D; Fontinha D; Silva VLM; Almeida Paz FA; Madureira AM; et al. "Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 Coupling and Domino Cyclization Approach.". ChemMedChem (2023): http://europepmc.org/abstract/med/37392377.
    10.1002/cmdc.202300264
  6. Fonte M; Fontinha D; Moita D; Caño-Prades O; Avalos-Padilla Y; Fernàndez-Busquets X; Prudêncio M; Gomes P; Teixeira C. "New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial leads.". European journal of medicinal chemistry (2023): http://europepmc.org/abstract/med/37390511.
    10.1016/j.ejmech.2023.115575
  7. S Mendes S; Sorg M; Luís CM; Fontinha D; Francisco D; Moita D; C Romão C; et al. "Conjugated carbon monoxide-releasing molecules have broad-spectrum antimicrobial activity.". Future medicinal chemistry (2023): http://europepmc.org/abstract/med/37458074.
    10.4155/fmc-2023-0103
  8. Katerina Breiterová; Aneta Ritomská; Diana Fontinha; Jana Kroustková; Daniela Suchánková; Anna Hostalkova; Marcela Šafratová; et al. "Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of Plasmodium berghei Infection In Vitro". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/3/1007.
    10.3390/pharmaceutics15031007
  9. Silva AT; Oliveira IS; Gomes J; Aguiar L; Fontinha D; Duarte D; Nogueira F; et al. "Corrigendum: Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine.". ChemMedChem (2022): http://europepmc.org/abstract/med/36480787.
    10.1002/cmdc.202200589
  10. Alves AJS; Alves NG; Bártolo I; Fontinha D; Caetano S; Prudêncio M; Taveira N; Pinho E Melo TMVD. "Unveiling a family of spiro-ß-lactams with anti-HIV and antiplasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates.". Frontiers in chemistry (2022): http://europepmc.org/abstract/med/36277353.
    10.3389/fchem.2022.1017250
  11. Yann Le Gal; Agathe Filatre-Furcate; Dominique Lorcy; Olivier Jeannin; Thierry ROISNEL; Vincent Dorcet; Diana Fontinha; et al. "Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/13/7146.
    10.3390/ijms23137146
  12. Caroline De Souza Pereira; Helenita Quadros; Sammy Yaw Aboagye; Diana Fontinha; Sarah D'Alessandro; Margaret Elizabeth Byrne; mathieu gendrot; et al. "A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/6/1251.
    10.3390/pharmaceutics14061251
  13. Khandelwal A; Arez F; Alves PM; Badolo L; Brito C; Fischli C; Fontinha D; et al. "Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside.". Malaria journal (2022): http://europepmc.org/abstract/med/35570264.
    10.1186/s12936-022-04171-0
  14. Delphine Jublot; pierre cavailles; Salima Kamche; Denise Francisco; Diana Fontinha; Miguel Prudêncio; Jean-Francois Guichou; et al. "A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti-Toxoplasma and Anti-Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/6/3254.
    10.3390/ijms23063254
  15. Fontinha D; Arez F; Gal IR; Nogueira G; Moita D; Baeurle THH; Brito C; et al. "Pre-erythrocytic Activity of M5717 in Monotherapy and Combination in Preclinical Plasmodium Infection Models.". ACS infectious diseases (2022): http://europepmc.org/abstract/med/35312290.
    10.1021/acsinfecdis.1c00640
  16. Lopes EA; Mestre R; Fontinha D; Legac J; Pei JV; Sanches-Vaz M; Mori M; et al. "Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity.". European journal of medicinal chemistry (2022): http://europepmc.org/abstract/med/35390711.
    10.1016/j.ejmech.2022.114324
  17. Singh L; Fontinha D; Francisco D; Prudêncio M; Singh K. "Synthesis and antiplasmodial activity of regioisomers and epimers of second-generation dual acting ivermectin hybrids.". Scientific reports (2022): http://europepmc.org/abstract/med/35022455.
    10.1038/s41598-021-04532-w
  18. Silva AT; Oliveira IS; Gomes J; Aguiar L; Fontinha D; Duarte D; Nogueira F; et al. "Drug-Derived Surface-Active Ionic Liquids: A Cost-Effective Way To Expressively Increase the Blood-Stage Antimalarial Activity of Primaquine.". ChemMedChem (2021): http://europepmc.org/abstract/med/34882979.
    10.1002/cmdc.202100650
  19. Helenita Quadros; Aysun Çapci; Lars Herrmann; Sarah D'Alessandro; Diana Fontinha; Raquel Azevedo; Wilmer Villarreal; et al. "Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle". Pharmaceuticals (2021): https://www.mdpi.com/1424-8247/14/11/1129.
    10.3390/ph14111129
  20. Marinovic M; Poje G; Perkovic I; Fontinha D; Prudêncio M; Held J; Pessanha de Carvalho L; et al. "Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action.". European journal of medicinal chemistry (2021): http://europepmc.org/abstract/med/34274829.
    10.1016/j.ejmech.2021.113687
  21. Sharma N; Kashif M; Singh V; Fontinha D; Mukherjee B; Kumar D; Singh S; et al. "Novel Antiplasmodial Compounds Leveraged with Multistage Potency against the Parasite Plasmodium falciparum: In Vitro and In Vivo Evaluations and Pharmacokinetic Studies.". Journal of medicinal chemistry (2021): http://europepmc.org/abstract/med/34124905.
    10.1021/acs.jmedchem.1c00659
  22. Alves NG; Bártolo I; Alves AJS; Fontinha D; Francisco D; Lopes SMM; Soares MIL; et al. "Synthesis and structure-activity relationships of new chiral spiro-ß-lactams highly active against HIV-1 and Plasmodium.". European journal of medicinal chemistry (2021): http://europepmc.org/abstract/med/33887681.
    10.1016/j.ejmech.2021.113439
  23. Tavella TA; da Silva NSM; Spillman N; Kayano ACAV; Cassiano GC; Vasconcelos AA; Camargo AP; et al. "Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity.". ACS infectious diseases (2021): http://europepmc.org/abstract/med/33689276.
    10.1021/acsinfecdis.0c00454
  24. Bártolo I; Santos BS; Fontinha D; Machado M; Francisco D; Sepodes B; Rocha J; et al. "Spiro-ß-lactam BSS-730A Displays Potent Activity against HIV and Plasmodium.". ACS infectious diseases (2021): http://europepmc.org/abstract/med/33395253.
    10.1021/acsinfecdis.0c00768
  25. Fonte M; Tassi N; Fontinha D; Bouzón-Arnáiz I; Ferraz R; Araújo MJ; Fernàndez-Busquets X; et al. "4,9-Diaminoacridines and 4-Aminoacridines as Dual-Stage Antiplasmodial Hits.". ChemMedChem (2020): http://europepmc.org/abstract/med/33217195.
    10.1002/cmdc.202000740
  26. Meireles P; Brás D; Fontinha D; Chora ÂF; Serre K; Mendes AM; Prudêncio M. "Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation.". iScience (2020): http://europepmc.org/abstract/med/33294789.
    10.1016/j.isci.2020.101781
  27. de Souza Pereira C; Costa Quadros H; Magalhaes Moreira DR; Castro W; Santos De Deus Da Silva RI; Botelho Pereira Soares M; Fontinha D; Prudêncio M; Navarro M. "A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent.". ChemMedChem (2020): http://europepmc.org/abstract/med/33231370.
    10.1002/cmdc.202000653
  28. Marina Marinovic; Ivana Perkovic; Diana Fontinha; Miguel Prudêncio; Jana Held; Lais Pessanha de Carvalho; Tana Tandaric; et al. "Novel Harmicines with Improved Potency against Plasmodium". Molecules (2020): https://www.mdpi.com/1420-3049/25/19/4376.
    10.3390/molecules25194376
  29. Milheiro SA; Gonçalves J; Lopes RMRM; Madureira M; Lobo L; Lopes A; Nogueira F; et al. "Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype.". Inorganic chemistry (2020): http://europepmc.org/abstract/med/32838513.
    10.1021/acs.inorgchem.0c01795
  30. Fontinha D; Moules I; Prudêncio M. "Repurposing Drugs to Fight Hepatic Malaria Parasites.". Molecules (Basel, Switzerland) (2020): http://europepmc.org/abstract/med/32731386.
    10.3390/molecules25153409
  31. Fontinha, Diana; Sousa, Silvia Andreia; Morais, Tânia S.; Prudêncio, Miguel; Leitão, Jorge; Le Gal, Yann; Lorcy, Dominique; et al. "Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents". Metallomics (2020): http://dx.doi.org/10.1039/d0mt00064g.
    10.1039/d0mt00064g
  32. Singh L; Fontinha D; Francisco D; Mendes AM; Prudêncio M; Singh K. "Molecular Design and Synthesis of Ivermectin Hybrids Targeting Hepatic and Erythrocytic Stages of Plasmodium Parasites.". Journal of medicinal chemistry (2020): http://europepmc.org/abstract/med/32011136.
    10.1021/acs.jmedchem.0c00033
  33. Alves AJS; Alves NG; Caratão CC; I M Esteves M; Fontinha D; Bártolo I; Soares MIL; et al. "Spiro-Lactams as Novel Antimicrobial Agents.". Current topics in medicinal chemistry (2019): http://europepmc.org/abstract/med/31702503.
    10.2174/1568026619666191105110049
  34. Perkovic I; Raic-Malic S; Fontinha D; Prudêncio M; Pessanha de Carvalho L; Held J; Tandaric T; et al. "Harmicines - harmine and cinnamic acid hybrids as novel antiplasmodial hits.". European journal of medicinal chemistry (2019): http://europepmc.org/abstract/med/31812035.
    10.1016/j.ejmech.2019.111927
  35. Sousa SA; Leitão JH; Silva RAL; Belo D; Santos IC; Guerreiro JF; Martins M; et al. "On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities.". Journal of inorganic biochemistry (2019): http://europepmc.org/abstract/med/31671298.
    10.1016/j.jinorgbio.2019.110904
  36. Arez F; Rebelo SP; Fontinha D; Simão D; Martins TR; Machado M; Fischli C; et al. "Flexible 3D Cell-Based Platforms for the Discovery and Profiling of Novel Drugs Targeting Plasmodium Hepatic Infection.". ACS infectious diseases (2019): http://europepmc.org/abstract/med/31479238.
    10.1021/acsinfecdis.9b00144
  37. Beus M; Fontinha D; Held J; Rajic Z; Uzelac L; Kralj M; Prudêncio M; Zorc B. "Primaquine and Chloroquine Fumardiamides as Promising Antiplasmodial Agents.". Molecules (Basel, Switzerland) (2019): http://europepmc.org/abstract/med/31374989.
    10.3390/molecules24152812
  38. Pavic K; Rubinic B; Rajic Z; Fontinha D; Prudêncio M; Uzelac L; Kralj M; Held J; Zorc B. "Primaquine homodimers as potential antiplasmodial and anticancer agents.". Bioorganic & medicinal chemistry letters (2019): http://europepmc.org/abstract/med/31431364.
    10.1016/j.bmcl.2019.08.018
  39. Wolanin K; Fontinha D; Sanches-Vaz M; Nyboer B; Heiss K; Mueller AK; Prudêncio M. "A crucial role for the C-terminal domain of EXP1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle.". Cellular microbiology (2019): http://europepmc.org/abstract/med/31364224.
    10.1111/cmi.13088
  40. Beus M; Fontinha D; Held J; Rajic Z; Prudêncio M; Zorc B. "Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides.". Acta pharmaceutica (Zagreb, Croatia) (2019): http://europepmc.org/abstract/med/31259728.
    10.2478/acph-2019-0019
  41. Kumar M; Okombo J; Mambwe D; Taylor D; Lawrence N; Reader J; van der Watt M; et al. "Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action.". ACS infectious diseases (2019): http://europepmc.org/abstract/med/30525439.
    10.1021/acsinfecdis.8b00272
  42. Mayoka G; Njoroge M; Okombo J; Gibhard L; Sanches-Vaz M; Fontinha D; Birkholtz LM; et al. "Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria.". Journal of medicinal chemistry (2018): http://europepmc.org/abstract/med/30562027.
    10.1021/acs.jmedchem.8b01769
  43. Beus M; Rajic Z; Maysinger D; Mlinaric Z; Antunovic M; Marijanovic I; Fontinha D; et al. "SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents.". ChemistryOpen (2018): http://europepmc.org/abstract/med/30151334.
    10.1002/open.201800117
  44. Šafratová M; Hoštálková A; Hulcová D; Breiterová K; Hrabcová V; Machado M; Fontinha D; et al. "Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity.". Archives of pharmacal research (2017): http://europepmc.org/abstract/med/29243039.
    10.1007/s12272-017-1000-4
  45. Fontinha, Diana. "Primaquine hybrids as promising antimycobacterial and antimalarial agents.". European journal of medicinal chemistry (2017): http://europepmc.org/abstract/med/29220797.
    10.1016/j.ejmech.2017.11.083
  46. Sá E Cunha C; Nyboer B; Heiss K; Sanches-Vaz M; Fontinha D; Wiedtke E; Grimm D; et al. "Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.". (2017): http://europepmc.org/abstract/med/28137845.
    10.1073/pnas.1606419114
  47. Barros-Martins J; Schmolka N; Fontinha D; Pires de Miranda M; Simas JP; Brok I; Ferreira C; et al. "Effector ¿d T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.". (2016): http://europepmc.org/abstract/med/26994218.
    10.4049/jimmunol.1501921
  48. Fontinha D; Lopes FB; Marques S; Alenquer M; Simas JP. "Correction: Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells.". (2015): http://europepmc.org/abstract/med/26694642.
    10.1371/journal.pone.0145942
  49. Fontinha D; Lopes FB; Marques S; Alenquer M; Simas JP. "Murid Gammaherpesvirus Latency-Associated Protein M2 Promotes the Formation of Conjugates between Transformed B Lymphoma Cells and T Helper Cells.". (2015): http://europepmc.org/abstract/med/26544979.
    10.1371/journal.pone.0142540
  50. Decalf J; Godinho-Silva C; Fontinha D; Marques S; Simas JP. "Establishment of murine gammaherpesvirus latency in B cells is not a stochastic event.". (2014): http://europepmc.org/abstract/med/25079788.
    10.1371/journal.ppat.1004269
  51. Godinho-Silva C; Marques S; Fontinha D; Veiga-Fernandes H; Stevenson PG; Simas JP. "Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.". (2014): http://europepmc.org/abstract/med/24967892.
    10.1371/journal.ppat.1004220
Poster em conferência
  1. Fontinha, Diana; Parth; Sofia Santana; Catarina Rôla; Carla Bastos Oliveira; Prudêncio, Miguel; Singh, Kamaljit. "Antiplasmodial and insecticidal activities of third generation ivermectin hybrids". Trabalho apresentado em American Society of Tropical Medicine & Hygiene (ASTMH) Annual Meeting, 2024.
  2. Fontinha, Diana; Arez, Francisca; Rebelo, Sofia; Simão, Daniel; Martins, Tatiana R.; Machado, Marta; Carrondo, Manuel J. T.; et al. "3D hepatic models - an innovative platform for the screening of anti-plasmodial drugs". Trabalho apresentado em TwinnToInfect Spring School on Infection and Immunity, 2018.
  3. Fontinha, Diana; Lopes, Filipa; Alenquer, Marta; Marques, Sofia; Simas, Pedro. "Herpesvirus modulation of immunological synapses". Trabalho apresentado em British Society for Immunology Congress, 2013.
  4. Fontinha, Diana; Lopes, Filipa; Alenquer, Marta; Marques, Sofia; Simas, Pedro. "Herpesvirus modulation of immunological synapses". Trabalho apresentado em VI IMM/CAML PhD Students Meeting, 2012.
Tese / Dissertação
  1. Fontinha, Diana. "Murid herpesvirus-4 modulation of B-T helper cell interaction". Doutoramento, 2016. http://hdl.handle.net/10451/26271.

Propriedade Intelectual

Patente
  1. Spangenberg, Thomas; Greco, Beatrice; Alves, Paula M; Carrondo, Manuel JT; Brito, Catarina; Rebelo, Sofia P; Arez, Francisca; et al. 2018. "Infected cell cultures".

Outros

Outra produção
  1. Half- Sandwich cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype. 2020. Milheiro SA; Gonçalves J; Lopes R; Madureira M; Lobo L; Lopes A; Nogueira F; et al. http://europepmc.org/abstract/PPR/PPR153029.
    10.26434/chemrxiv.12155178.v1
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/05/27 3D hepatic models an innovative platform for translating anti plasmodial liver stage activity BioMalPar XVII: Biology and Pathology of the Malaria Parasite
EMBL Conference
2017 Development of 3D hepatic cell models of liver stage malaria infection as screening tools for novel anti-Plasmodial drugs iMM PostDoc Day
Instituto de Medicina Molecular (Lisboa, Portugal)
2015 Herpesvirus modulation of immunological synapses IX IMM/CAML PhD Students Meeting
Instituto de Medicina Molecular (Lisboa, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/03/04 - Atual A Multifaceted Approach to Combatting Plasmodium vivax Malaria: Whole Sporozoite Vaccines, Adjuvants, and Monoclonal Antibodies
Coorientador
Universidade de Lisboa Faculdade de Medicina, Portugal
2023/09/01 - Atual Whole-organism vaccines against Plasmodium vivax malaria
Orientador
 Applied Microbiology (Mestrado)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/09/01 - 2023/11/30 Screening of compounds against malaria parasites
Orientador
 MSc Microbiology (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/09/01 - 2022/02/24 Drug repurposing against malaria parasites
Orientador
 Microbiologia Clínica e Doenças Infeciosas Emergentes (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/04/29 - 2019/04/29 International Immunology Day (2019/04/29 - 2019/04/29)
Oficina (workshop) (Membro da Comissão Organizadora)
 Instituto de Medicina Molecular João Lobo Antunes, Portugal
2015/03/26 - 2015/03/27 IX IMM/CAML PhD Students Meeting (2015/03/26 - 2015/03/27)
Encontro (Membro da Comissão Organizadora)
 Instituto de Medicina Molecular João Lobo Antunes, Portugal
2014/03/28 - 2014/03/28 VIII IMM/CAML PhD Students Meeting (2014/03/28 - 2014/03/28)
Encontro (Membro da Comissão Organizadora)
 Instituto de Medicina Molecular João Lobo Antunes, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/11/14 - 2022/11/18 Autumn Training School 2022 - Drug development and discovery course
Outro
EU-OPENSCREEN ERIC, Alemanha
2022/10/10 - 2022/10/16 Festival Internacional de Ciência 2022 (FIC.A 2022)
Exposição
 Festival Internacional de Ciência 2022 (FIC.A 2022)
2018 - 2018 TwinnToInfect Spring School on Infection and Immunity
Encontro
 TwinnToInfect Spring School on Infection and Immunity
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2018 - 2018 Lisbon Area PostDoctoral Meeting
Encontro
 Lisbon Area PostDoctoral Meeting
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Fundação Champalimaud, Portugal

REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2017 - 2017 European Researchers Night
Exposição
2015 - 2015 Statistics for begginners course
Outro
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2012 - 2012 Flow Cytometry Course
Outro
 Flow Cytometry Course
Instituto de Medicina Molecular João Lobo Antunes, Portugal
2012 - 2012 Bioimaging Nano Course on Microscopy
Outro
 Bioimaging Nano Course on Microscopy
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2019/11/20 Study of SUMO-2-interacting motifs in Kaposi's sarcoma-associated herpesvirus
Arguente principal
 Catarina Neves Costa (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Distinções

Outra distinção

2017 Best graphical abstract presentation at iMM PostDoc Day
Instituto de Medicina Molecular, Portugal
2012 Doctoral Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2010 Best course performance (MSc Molecular Medical Microbiology 2009/10)
University of Nottingham, Reino Unido
2009 Merit Scholarship
Universidade de Lisboa Faculdade de Ciências, Portugal
2008 Honorable Mention - Best 1st year 1st time students of the Faculty of Science, University of Lisbon
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal