Sofia Azeredo Gaspar Pereira (6B13-7601-73A2)

Curriculum Vitae

Sofia Azeredo Gaspar Pereira

Sofia Azeredo Gaspar Pereira (SAP) completed her PhD in Pharmacology (2010) and is Assistant Professor with aggregation at NOVA Medical School, NMS Universidade Nova de Lisboa. She is/has been Vice-director of the PhD Program in Biomedicine, Coordinator of the Therapeutic Drug Monitoring and Responsible for the Analytical Facility. She is a researcher at iNOVA4Health FCT Research Unit. SAP is a pharmacologist and the head of the Renal, Cardiovascular and Metabolic Pharmacology lab at NOVA Medical School. SAP leads a research line with collaboration to Peritoneal Dialysis Unit of CHLO, dedicated to biomarkers and clinical pharmacology studies for better outcomes in this renal replacement therapy, and led pioneer work that links galectin-3 to membrane failure. SAP research foous AhR as a druggable target in cardiovascular-renal disease spectrum. She investigates AhR involvement in fibrosis and metabolic adaptations to microenvironmental conditions. SAP is/has been a member of two European networks on hypertension and Kidney disease; she integrates the network Pharmacological regulation of NRF2 in non communicable diseases; She is a member of the working group translational nephrology at the Portuguese Society of Nephrology; She is/has been PI of a patent of a compound to treat diseases associated with HDL-dysfunction; member of the team of 2 clinical trials Her team has identified mechanisms of toxicity for 5 drugs and a biomarker of kidney disease progression conducting research in experimental models ( rodents, zebra fish, 3D cell culture) and clinical studies. She has been collaborating (since 2001) with Clinical Teams from Hospitals in Lisbon Area, with several common publications. Applying a mechanistically-oriented approach, Sofia´s team has identified populations of patients that are at higher risk for adverse drug reactions towards precision therapy (eg. gender differences, menopause). Currently, and supported by her background in drug toxicity, she is investigating how drug metabolic pathways impact non-communicable diseases Arterial Hypertension, Kidney Disease) towards patients deeply phenotyping and stratification and looking for a new generation of drugs targeting the interaction ENVIRONMENT-DISEASE.

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Identificação

Identificação pessoal

Nome completo: Sofia Azeredo Gaspar Pereira

Nomes de citação

Pereira, Sofia A.

Identificadores de autor

Ciência ID: 6B13-7601-73A2
ORCID iD: 0000-0002-8456-9995
Google Scholar ID: https://scholar.google.com.br/citations?user=UJ6bS8QAAAAJ&hl=pt-PT&authuser=1
Scopus Author Id: 35190948700

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2022/12 Concluído	Aggregated in Health Sciences, Biomedicine (Título de Agregado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2011 - 2011 Concluído	Pos doctoral, Netherlands, Training on LC-MS methodologies (Pós-doutoramento) Slotervaart Hospital - Department of Pharmacy & Pharmacology, Países Baixos
2010/03/03 - 2010/09/06 Concluído	USA, NCTR, Postdoctoral Training in Epigenetics/Toxicology (Pós-doutoramento) National Center for Toxicological Research, Estados Unidos
2006/01 - 2010/01/14 Concluído	Pharmacology (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal "Monitorização das concentrações plasmáticas de efavirenz: critérios de aplicabilidade à prática clínica e efeitos do fármaco a longo termo/Therapeutic drug monitoring of Efavirenz: criteria and long-term drug effects" (TESE/DISSERTAÇÃO)	Maximal
2002 - 2002 Concluído	Short-term formation - Quantification of drugs by HPLC (Outros) Hospital Clínic de Barcelona, Espanha
2001 - 2002 Concluído	Graduation Thesis: Development and validation of a HPLC method to quantify efavirenz plasma concentration in HIV-infected patients (Outros) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2002 Concluído	Bioquímica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2011/03/01 - 2011/10/09	Pós-doutorado (Investigação)	MC Slotervaart, Países Baixos
	MC Slotervaart, Países Baixos
2010/05/01 - 2010/08/06	Pós-doutorado (Investigação)	National Center for Toxicological Research, Estados Unidos

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2012 - 2022	Professor Auxiliar (Docente Universitário)	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2022/02 - Atual	Group Leader at Renal, Cardiovascular and Metabolic Pharmacology lab	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

2022/01 - Atual	Head of Pharmacology 1 Integrated Master in Medicine	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

2019 - Atual	Coordinator of the Pedagogic Comission of the 2nd year of the Integrated Master Degree in Medicine	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

2018 - Atual	Vice-director of the PhD Program in Biomedicine	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

2016 - Atual	Responsible for the Analytical Facility	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - Atual	Coordinator of the Therapeutic Drug Monitoring Unit	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

2019 - 2022	Head of the Curricular Unit "General Pharmacology" of the Integrated Master degree in Medicine	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2021	Head of the Curricular Unit "Aging and chronic diseases: from molecular mechanisms to therapies" of the Master's Degree NOVA Biomedical Research	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2022 - Atual	Assistant Professor with aggregation in Health Sciences, Biomedicine	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

2021 - Atual	co-Group Leader at iNOVA4Health FCT Research Unit Cardiometabolic diseases	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

2019 - 2021	co-Group Leader Translational Pharmacology lab	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2006/10/02 - 2010/01/14	PhD student	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2002/10/01 - 2002/11/01	Research fellow	Hospital Clínic de Barcelona, Espanha

2001/10/01 - 2002/03/31	PRODEPT grant graduationThesis	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Projetos

Bolsa

	Designação	Financiadores
2002 - 2003	Clinical efficacy and therapeutic drug monitoring of antiretroviral drugs in HIV infected patients taking rifamycins POCTI/FCB/42664/2001 Bolseiro de Investigação Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2001 - 2002	Development and validation of a HPLC method to quantify efavirenz plasma concentration in HIV-infected patients PRODEPT Bolseiro de Investigação Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Concluído

Projeto

	Designação	Financiadores
2023 - Atual	Mass spectrometry & Machine Learning pipeline to tackle Chronic Kidney Disease & Resistant Hypertension: a guide for patient subtyping & precision medicine FCT 2022.06292.PTDC Investigador	Fundação para a Ciência e a Tecnologia Em curso
2021 - Atual	Muscle up with intermittent hypoxia: a matter of intensity, gender and metabolism iNOVA4Health- IUDB/004462/2020/TL2/P2 Investigador responsável Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal iNOVA4Health, Portugal	iNOVA4Health Fundação para a Ciência e a Tecnologia Em curso
2018/10/01 - 2021/09/30	AhR-CYP1A:1 linking environmental exposure and sleep apnea to improve arterial hypertension management PTDC/MED-TOX/30418/2017 Investigador responsável Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/10/01 - 2021/09/30	Photonic biosensor for point of care and early diagnostics of acute kidney injury PTDC/NAN-OPT/31311/2017 Investigador Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal Universidade Nova de Lisboa UNINOVA Instituto de Desenvolvimento de Novas Tecnologias, Portugal Universidade Nova de Lisboa, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2016 - 2020	Diagnosis, monitoring and prevention of exposure-related non-communicable diseases (DiMoPEx/CA15129)). CA15129 Investigador Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	European Cooperation in Science and Technology Concluído
2017 - 2019	Efficacy of olive oil and phenolic compounds in reversing hypertension induced by chronic intermittent hypoxia 201707-05-30 iNOVA4Health, Portugal	iNOVA4Health Concluído
2016 - 2019	(per)Sulfidomics: benchmarking mechanisms underlying drug toxicity and drug resistance in precision medicine UID/Multi/04462/2013 iN4H_201601-02-021 Investigador responsável iNOVA4Health, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016 - 2019	AhR: a therapeutic target for co-morbidities associated with chronic intermittent hypoxia PAULIF Investigador	Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior Gouvernement francais Ministère de l'Enseignement supérieur de la Recherche et de l'Innovation Concluído
2016 - 2018	(Clinical Trial) Variability of sulfotransferase 1A1 activity in humans: an approach to improve predictive drug response 2016-001395-29 NCT03182595: Investigador Hospital da Luz Lisboa, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Hospital da Luz Lisboa Em curso
2016 - 2018	Targeting monocytes as angiogenesis promoters in cancer- New application for old drugs Inova4health 201707-05-35 Investigador responsável	Concluído
2016 - 2017	Kidney tubular lesion in HIV patients PGG/032/2015 Investigador Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Gilead Sciences Lda Concluído
2013/06/01 - 2016/12/31	From small bioactive molecules to an integrated OMICS approach: Mass Spectrometry tools for mechanistic insights into drug-like and functional properties, toxicity, and stress responses RECI/QEQ-MED/0330/2012 Investigador Universidade de Lisboa Centro de Química Estrutural, Portugal Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Centro Hospitalar de Lisboa Central EPE, Portugal Hospital Professor Doutor Fernando Fonseca EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2014/03/18 - 2015/09/17	HivKIomics - new insights on tubular injury and nephrotoxicity diagnosis and prediction in HIV-infected patients EXPL/DTP-FTO/1792/2013 Investigador Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Hospital Professor Doutor Fernando Fonseca EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2014/04/01 - 2015/06/30	Point of care testing of cardiovascular disease markers - detection of homocystein-thiolactone EXPL/DTP-PIC/1758/2013 Investigador Egas Moniz Cooperativa de Ensino Superior CRL, Portugal Centro de Investigação Interdisciplinar Egas Moniz, Portugal Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013 - 2015	HIV nefromics: new markers of nephrotoxicity induced by antiretrovirals in hiv+ patients SPN2013 Investigador Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Sociedade Portuguesa de Nefrologia
2012 - 2015	Zebrafish as a biomedical tool to evaluate drug toxicity FCG121986 Investigador Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal	Fundação Calouste Gulbenkian Concluído
2013/11/02 - 2014/11/01	TeachIng an olD drug nEw tricks: re-profiling An anti-HIV drug as an HDL modulator EXPL/DTP-FTO/0204/2012 Investigador responsável Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade de Lisboa Faculdade de Farmácia, Portugal Centro Hospitalar de Lisboa Central EPE, Portugal Hospital Professor Doutor Fernando Fonseca EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/03/15 - 2014/09/14	Hepatic toxicity in HIV-infected individuals exposed to nevirapine PTDC/SAU-TOX/111663/2009 Investigador Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal Centro Hospitalar de Lisboa Central EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010 - 2013	Bioactivation routes of the anti - HIV drug Nevirapine: identification of reactive metabolites and mutagenic potential PTDC/QUI-QUI/113910/2009 Investigador Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade de Lisboa Instituto Superior Técnico, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2002 - 2004	Implementation of a laboratory for therapeutic drug monitoring of antiretroviral drugs in HIV infected patients CNLCS2002 Bolseiro de Investigação	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em conferência	Gracio, Patricia C.; Goncalves-Dias, Clara; Lopes-Coelho, Filipa; Monteiro, Emilia C.; Serpa, Jacinta; da Silva, Claudia L.; Pereira, Sofia A.. "Changes in N-acetyltransferase 8 in kidney tubular cell: injury, recovery and mesenchymal stromal cell-based therapy". 2019. 10.1109/enbeng.2019.8692517 Pereira, Sofia; Pereira SA; Pereira, Sofia A.. "Epigenetic Markers of Hepatotoxicity: A Nevirapine Story". Trabalho apresentado em 41st Annual Meeting of Environmental-Mutagen-Society, 2010. https://doi.org/10.1002/em.20625 Pereira SA; RM Corte-Real; T Branco; F Lampreia; I Germano; U Caixas; E.C. Monteiro. "Efavirenz plasma concentrations - Is gender important?". 2004.
Artigo em revista	Fernandes, Joana L.; Martins, Fátima O.; Olea, Elena; Prieto-Lloret, Jesus; Braga, Patrícia C.; Sacramento, Joana F.; Sequeira, Catarina O.; et al. "Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation". Antioxidants 12 11 (2023): 1910. http://dx.doi.org/10.3390/antiox12111910. Publicado • 10.3390/antiox12111910 Martins, Ana Rita; Azeredo-Lopes, Sofia; Pereira, Sofia Azeredo; Moreira, Inês; Weigert, André Luíz. "Klotho and lean mass as novel cardiovascular risk factors in hemodialysis patients". Clinical Kidney Journal 16 12 (2023): 2587-2596. http://dx.doi.org/10.1093/ckj/sfad166. Publicado • 10.1093/ckj/sfad166 Baltazar, Pedro; de Melo Junior, Antonio Ferreira; Fonseca, Nuno Moreira; Lança, Miguel Brito; Faria, Ana; Sequeira, Catarina O.; Teixeira-Santos, Luísa; et al. "Oxalate (dys)Metabolism: Person-to-Person Variability, Kidney and Cardiometabolic Toxicity". Genes 14 9 (2023): 1719. http://dx.doi.org/10.3390/genes14091719. Publicado • 10.3390/genes14091719 Dias-Carvalho, Ana; Margarida-Araújo, Ana; Reis-Mendes, Ana; Sequeira, Catarina Oliveira; Pereira, Sofia Azeredo; Guedes de Pinho, Paula; Carvalho, Félix; et al. "A Clinically Relevant Dosage of Mitoxantrone Disrupts the Glutathione and Lipid Metabolic Pathways of the CD-1 Mice Brain: A Metabolomics Study". International Journal of Molecular Sciences 24 17 (2023): 13126. http://dx.doi.org/10.3390/ijms241713126. Publicado • 10.3390/ijms241713126 Zhang, Junmin; Wang, Rong; Pereira, Sofia Azeredo. "Editorial: Drug metabolism and transport: the Frontier of personalized medicine". Frontiers in Pharmacology 14 (2023): http://dx.doi.org/10.3389/fphar.2023.1246827. Publicado • 10.3389/fphar.2023.1246827 Pimpão, António; Sousa, Cátia; Correia, M João; Coelho, Nuno; Monteiro, EC; Melo Junior, AF; Pereira, Sofia A.. "Control of Arterial Hypertension by the AhR Blocker CH-223191: A Chronopharmacological Study in Chronic Intermittent Hypoxia Conditions". Advances in Experimental Medicine and Biology 147 (2023): Publicado • https://doi.org/10.1007/978-3-031-32371-3_4 Pepe, Bruno; Prazeres, Teresa; Carnevale, Andreia; Calça, Rita; Matias, Patricia; Branco, Patricia; Azeredo-Lopes, Sofia; Pereira, Sofia Azeredo; Martins, Ana Rita. "#3546 “SURPRISE QUESTION”: IS IT A USEFUL TOOL IN CKD STAGES 4 TO 5?". Nephrology Dialysis Transplantation 38 Supplement (2023): http://dx.doi.org/10.1093/ndt/gfad063c_3546. Publicado • 10.1093/ndt/gfad063c_3546 Mauricio, Miguel Nuno Petrucci; Merino, Jaime Hernán; Carnevale, Andreia; Pereira, Sofia Azeredo; Martins, Ana Rita; Calça, Rita; Matias, Patricia; et al. "#2674 ASSOCIATION BETWEEN SARCOPENIA, BODY COMPOSITION AND FRAILTY IN PERITONEAL DIALYSIS PATIENTS: A MULTI-CENTRIC STUDY". Nephrology Dialysis Transplantation 38 Supplement (2023): http://dx.doi.org/10.1093/ndt/gfad063b_2674. Publicado • 10.1093/ndt/gfad063b_2674 Branco, Patrícia; Calça, Rita; Martins, Ana Rita; Mateus, Catarina; Jervis, Maria João; Gomes, Daniel Pinto; Azeredo-Lopes, Sofia; et al. "Fibrosis of Peritoneal Membrane, Molecular Indicators of Aging and Frailty Unveil Vulnerable Patients in Long-Term Peritoneal Dialysis". International Journal of Molecular Sciences 24 5 (2023): 5020. http://dx.doi.org/10.3390/ijms24055020. 10.3390/ijms24055020 Branco, Patrícia; Martins, Ana Rita; Calça, Rita; Mateus, Catarina; Jervis, Maria João; Rodrigues, Anabela; Lopes, Sofia Azeredo; et al. "Alpha-klotho and peritoneal membrane status: A hypothesis generating study". European Journal of Clinical Investigation 53 3 (2022): http://dx.doi.org/10.1111/eci.13903. 10.1111/eci.13903 Lopes-Coelho, Filipa; Martins, Filipa; Hipólito, Ana; Conde, Sílvia V.; Pereira, Sofia A.; Gonçalves, Luís G.; Serpa, Jacinta. "A Metabolic Signature to Monitor Endothelial Cell Differentiation, Activation, and Vascular Organization". Biomedicines 10 9 (2022): 2293. http://dx.doi.org/10.3390/biomedicines10092293. 10.3390/biomedicines10092293 Filipa Lopes-Coelho; Sofia Nunes; Filipa Martins; Ana Hipolito; Sofia Gouveia-Fernandes; Germana Domingues; Bernardete F. Melo; et al. "Propranolol therapy for cerebral cavernous malformations". World Academy of Sciences Journal 4 3 (2022): https://novaresearch.unl.pt/en/publications/2de56f91-0662-4c59-94ee-de2b4003af30. 10.3892/wasj.2022.158 Correia, Maria João; Pimpão, António B.; Fernandes, Dalila G. F.; Morello, Judit; Sequeira, Catarina O.; Calado, Joaquim; Antunes, Alexandra M. M.; et al. "Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine". Molecules 27 4 (2022): 1416. http://dx.doi.org/10.3390/molecules27041416. Publicado • 10.3390/molecules27041416 Carecho, Rafael; Figueira, Inês; Terrasso, Ana Paula; Godinho-Pereira, Joana; de Oliveira Sequeira, Catarina; Pereira, Sofia Azeredo; Milenkovic, Dragan; et al. "Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease". Molecular Nutrition & Food Research (2021): 2100959. http://dx.doi.org/10.1002/mnfr.202100959. 10.1002/mnfr.202100959 Coelho, N. R.; Pimpão, A. B.; Correia, M. J.; Rodrigues, T. C.; Monteiro, E. C.; Morello, J.; Pereira, S. A.. "Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence". Journal of Molecular Medicine 100 2 (2021): 215-243. http://dx.doi.org/10.1007/s00109-021-02163-2. Publicado • 10.1007/s00109-021-02163-2 Correia, Maria João; Pimpão, António B.; Lopes-Coelho, Filipa; Sequeira, Catarina O.; Coelho, Nuno R.; Gonçalves-Dias, Clara; Barouki, Robert; et al. "Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex". Antioxidants 10 9 (2021): 1484. http://dx.doi.org/10.3390/antiox10091484. Publicado • 10.3390/antiox10091484 Nunes, Sofia C.; Ramos, Cristiano; Santos, Inês; Mendes, Cindy; Silva, Fernanda; Vicente, João B.; Pereira, Sofia A.; et al. "Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.722412. Publicado • 10.3389/fcell.2021.722412 Filipa Lopes-Coelho; Filipa Martins; Ana Hipólito; Cindy Mendes; Catarina O. Sequeira; Rita F. Pires; António Almeida; et al. "The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism". Frontiers in Oncology 11 (2021): https://novaresearch.unl.pt/en/publications/8dcd8bcd-4c56-4a7a-88bb-98f7cbb92a78. 10.3389/fonc.2021.656229 Marto, Natalia; Morello, Judit; Antunes, Alexandra; Monteiro, Emília; Pereira, Sofia. "Phenotyping SULT in Man: a Simple Metric Using Paracetamol as Probe". The FASEB Journal 35 S1 (2021): http://dx.doi.org/10.1096/fasebj.2021.35.s1.03064. Publicado • 10.1096/fasebj.2021.35.s1.03064 Marto, Natália; Morello, Judit; Antunes, Alexandra M. M.; Azeredo, Sofia; Monteiro, Emília C.; Pereira, Sofia A.. "A simple method to measure sulfonation in man using paracetamol as probe drug". Scientific Reports 11 1 (2021): http://dx.doi.org/10.1038/s41598-021-88393-3. 10.1038/s41598-021-88393-3 Pereira, Sofia A.; Filipa Lopes-Coelho; Filipa Martins; Ana Hipólito; Cindy Mendes; Catarina O. Sequeira; Rita F Pires; et al. "The activation of endothelial cells relies on a ferroptosis-like mechanism: novel perspectives in management of angiogenesis and cancer therapy". Frontiers in Oncology 11 1666 (2021): Filipa Lopes-Coelho; Filipa Martins; Sofia A. Pereira; Jacinta Serpa. "Anti-Angiogenic Therapy: Current Challenges and Future Perspectives". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22073765. 10.3390/ijms22073765 Pereira, Sofia A.; Harjivan, Shrika G; Charneira, Catarina; Martins, Inês L; Espadas, Guadalupe; Sabidó, Eduard; Beland, Frederick A; Marques, M. Matilde; Antunes, Alexandra M.M.. "Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine". Molecules 2021 26 5 (2021): 1349-1349. https://doi.org/10.3390/molecules26051349. Publicado • 10.3390/molecules26051349 Célia M. Silveira; Patrícia R. Rodrigues; Wissam Ghach; Sofia A. Pereira; Francisco Esteves; Michel Kranendonk; Mathieu Etienne; M. Gabriela Almeida. "Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O 2 Control and the Natural Electron Donor". ChemElectroChem 8 3 (2021): 500-507. https://doi.org/10.1002/celc.202001255. 10.1002/celc.202001255 Célia M. Silveira; Patrícia R. Rodrigues; Wissam Ghach; Sofia A. Pereira; Francisco Esteves; Michel Kranendonk; Mathieu Etienne; M. Gabriela Almeida. "Front Cover: Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O 2 Control and the Natural Electron Donor (ChemElectroChem 3/2021)". ChemElectroChem 8 3 (2021): 425-425. https://doi.org/10.1002/celc.202001616. 10.1002/celc.202001616 Coelho, Nuno R.; Matos, Clara; Pimpão, António B.; Correia, M. João; Sequeira, Catarina O.; Morello, Judit; Pereira, Sofia A.; Monteiro, Emília C.. "AHR canonical pathway: in vivo findings to support novel antihypertensive strategies". Pharmacological Research (2021): 105407. http://dx.doi.org/10.1016/j.phrs.2020.105407. Publicado • 10.1016/j.phrs.2020.105407 Marinho, Aline T.; Batuca, Joana R.; Miranda, Joana P.; Caixas, Umbelina; Dias, Clara G.; Branco, Teresa; Soto, Karina; et al. "The 2-hydroxy-nevirapine metabolite as a candidate for boosting apolipoprotein A1 and for modulating anti-HDL antibodies". Pharmacological Research (2021): 105446. http://dx.doi.org/10.1016/j.phrs.2021.105446. 10.1016/j.phrs.2021.105446 Bonifácio, Vasco D. B.; Pereira, Sofia A.; Serpa, Jacinta; Vicente, João B.. "Cysteine metabolic circuitries: druggable targets in cancer". British Journal of Cancer (2020): http://dx.doi.org/10.1038/s41416-020-01156-1. Publicado • 10.1038/s41416-020-01156-1 Nuno R. Coelho; Céline Tomkiewicz; M. João Correia; Clara Gonçalves-Dias; Robert Barouki; Pereira SA; Xavier Coumoul; E.C. Monteiro. "First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia". Pharmacological Research 159 (2020): https://novaresearch.unl.pt/en/publications/c9eadc82-d6c7-4742-9746-a0becd09e55e. 10.1016/j.phrs.2020.104869 Gomes, A.; Godinho-Pereira, J.; Oudot, C.; Sequeira, C.O.; Macià, A.; Carvalho, F.; Motilva, M.J.; et al. "Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats". Free Radical Biology and Medicine 154 (2020): 119-131. http://dx.doi.org/10.1016/j.freeradbiomed.2020.05.002. 10.1016/j.freeradbiomed.2020.05.002 Madalena Cipriano; Pedro F Pinheiro; Catarina O Sequeira; Joana S Rodrigues; Nuno G Oliveira; Alexandra M M Antunes; Matilde Castro; et al. "Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and Glutathiolomic Profile of a Human Hepatocyte-Like Cell 3D Model". International Journal of Molecular Sciences 21 11 (2020): 3998-3998. https://doi.org/10.3390/ijms21113998. 10.3390/ijms21113998 Lopes-Coelho, Filipa; Silva, Fernanda; Gouveia-Fernandes, Sofia; Martins, Carmo; Lopes, Nuno; Domingues, Germana; Brito, Catarina; et al. "Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis". Cells 9 1 (2020): 107. http://dx.doi.org/10.3390/cells9010107. 10.3390/cells9010107 Santos, Inês; Ramos, Cristiano; Mendes, Cindy; Sequeira, Catarina O.; Tomé, Catarina S.; Fernandes, Dalila G.H.; Mota, Pedro; et al. "Targeting Glutathione and Cystathionine ß-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation". Nutrients 11 10 (2019): 2523. http://dx.doi.org/10.3390/nu11102523. 10.3390/nu11102523 Pereira; Antunes. "Special Issue "Adductomics: Elucidating the Environmental Causes of Disease"". High-Throughput 8 3 (2019): 17. http://dx.doi.org/10.3390/ht8030017. 10.3390/ht8030017 Gonçalves-Dias; Morello; Semedo; Correia; Coelho; Monteiro; Antunes; et al. "The mercapturomic profile of health and non-communicable diseases". High-Throughput 8 2 (2019): 10. http://dx.doi.org/10.3390/ht8020010. 10.3390/ht8020010 Nunes; Charneira; Morello; Rodrigues; Pereira; Antunes; Nunes, Joao; et al. "Mass Spectrometry-Based Methodologies for Targeted and Untargeted Identification of Protein Covalent Adducts (Adductomics): Current Status and Challenges". High-Throughput 8 2 (2019): 9. http://dx.doi.org/10.3390/ht8020009. 10.3390/ht8020009 Aline T. Marinho; Joana P. Miranda; Umbelina Caixas; Catarina Charneira; Clara Gonçalves-Dias; M. Matilde Marques; Emília C. Monteiro; Alexandra M. M. Antunes; Sofia A. Pereira. "Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity". Drug Metabolism Reviews (2019): 1-15. https://doi.org/10.1080/03602532.2019.1577891. 10.1080/03602532.2019.1577891 Gonçalves-Dias, Clara; Morello, Judit; Correia, M. João; Coelho, Nuno R.; Antunes, Alexandra M.M.; Macedo, Maria Paula; Monteiro, Emília C.; Soto, Karina; Pereira, Sofia A.. "Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease". Nephron 143 1 (2019): 17-23. http://dx.doi.org/10.1159/000494390. 10.1159/000494390 Figueiredo, Ines Carreira; Cargaleiro, Ines; Mueller, Stephanie; Aguiar, Pedro; Batuca, Joana R.; Pereira, Sofia Azeredo; Diogo, Lucilia; Ureche-Angelescu, Ilinca; Monteiro, Emilia C.. "PLATELET-LYMPHOCYTE RATIO AS A SHORT-TERM TREATMENT-RESPONSE PREDICTOR IN SCHIZOPHRENIA'S RELAPSE". Schizophrenia Bulletin (2019): https://publons.com/publon/28485534/. 10.1093/SCHBUL/SBZ018.425 Pereira, Sofia A.; Marinho AT; Lu H; Pereira SA; Monteiro E; Gabra H; Recchi C. "Anti-tumorigenic and Platinum-Sensitizing Effects of Apolipoprotein A1 and Apolipoprotein A1 Mimetic Peptides in Ovarian Cancer". Frontiers in Pharmacology (2019): https://publons.com/publon/20372505/. 10.3389/FPHAR.2018.01524 Caixas, U.; Sequeira, C. O.; Costa, J. P.; Azeredo-Lopes, S.; Maravilha, C.; Casella, I.; Soto, K.; et al. "Anti-Mullerian hormone a plausible indicator of cardiometabolic risk in HIV-infected women". HIV Medicine (2019): https://publons.com/wos-op/publon/52147058/. Charneira, C.; Pereira, S. A.; Antunes, A. M. M.; C. Charneira; Pereira SA; A. M. M. Antunes. "Biomarkers of exposure to estrogen-derived reactive metabolites: mass spectrometry-based methodologies to identify protein covalent adducts". Toxicology Letters (2019): https://publons.com/wos-op/publon/47267032/. https://doi.org/10.1016/j.toxlet.2019.09.002 Almeida, Ana S.; Soares, Nuno L.; Sequeira, Catarina O.; Pereira, Sofia A.; Sonnewald, Ursula; Vieira, Helena L.A.; Ana S. Almeida; et al. "Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway". Redox Biology 17 (2018): 338-347. http://dx.doi.org/10.1016/j.redox.2018.05.004. 10.1016/j.redox.2018.05.004 Godinho ALA; Martins IL; Nunes J; Charneira C; Grilo J; Silva DM; Pereira SA; et al. "High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches.". European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2018): http://europepmc.org/abstract/med/29592839. 10.1016/j.ejps.2018.03.026 Martins, Ines L.; Nunes, Joao; Charneira, Catarina; Morello, Judit; Pereira, Sofia A.; Telo, Joao P.; Matilde Marques, M.; et al. "The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals". Free Radical Biology and Medicine 129 (2018): 559-568. https://publons.com/publon/2894494/. 10.1016/J.FREERADBIOMED.2018.10.408 Nunes, Sofia C.; Ramos, Cristiano; Lopes-Coelho, Filipa; Sequeira, Catarina O.; Silva, Fernanda; Gouveia-Fernandes, Sofia; Rodrigues, Armanda; et al. "Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity". Scientific Reports 8 1 (2018): https://publons.com/publon/20372506/. 10.1038/S41598-018-27753-Y Nunes, Sofia C.; Lopes-Coelho, Filipa; Gouveia-Fernandes, Sofia; Ramos, Cristiano; Pereira, Sofia A.; Serpa, Jacinta. "Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer". BMC Evolutionary Biology 18 1 (2018): https://publons.com/publon/20372507/. 10.1186/S12862-018-1214-1 Morello, Judit; Derks, Rico J. E.; Lopes, Susana S.; Steenvoorden, Evelyne; Monteiro, Emilia C.; Mayboroda, Oleg A.; Pereira, Sofia A.; et al. "Zebrafish Larvae Are a Suitable Model to Investigate the Metabolic Phenotype of Drug-Induced Renal Tubular Injury". Frontiers in Pharmacology (2018): https://publons.com/publon/3082128/. 10.3389/FPHAR.2018.01193 Gorgulho, Rita; Jacinto, Raquel; Lopes, Susana S.; Pereira, Sofia A.; Tranfield, Erin M.; Martins, Gabriel G.; Gualda, Emilio J.; et al. "Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations". Archives of Toxicology (2018): https://publons.com/publon/7778768/. 10.1007/S00204-017-2063-1 Cipriano, Madalena; Pinheiro, Pedro F.; Sequeira, Catarina; Santos, Jorge M.; Oliveira, Nuno G.; Antunes, Alexandra M.M.; Matilde Marques, M.; et al. "3D in vitro cultures of human hepatocyte-like cells as an alternative competent model for nevirapine biotransformation studies (abstract EUROTOX 2017)". Toxicology Letters 280 (2017): S263. http://dx.doi.org/10.1016/j.toxlet.2017.07.932. 10.1016/j.toxlet.2017.07.932 Marto, Natalia; Morello, Judit; Monteiro, Emilia C.; Pereira, Sofia A.. "Implications of sulfotransferase activity in interindividual variability in drug response: clinical perspective on current knowledge". Drug Metabolism Reviews 49 3 (2017): 357-371. http://dx.doi.org/10.1080/03602532.2017.1335749. 10.1080/03602532.2017.1335749 Dias, Clara; Campos, Pedro; Diogo, Lucilia; Trigo, Diva; Correia, Maria João; Lemos, Ana; Monteiro, Emilia; Soto, Karina; Pereira, Sofia. "MP312 Kidney disease progression in hiv-infected patients related with the detoxification of endogenous electrophilic species (abstract 54th ERA-EDTA congress)". Nephrology Dialysis Transplantation 32 suppl_3 (2017): iii540-iii541. http://dx.doi.org/10.1093/ndt/gfx168.mp312. 10.1093/ndt/gfx168.mp312 Grilo NM; João Correia M; Miranda JP; Cipriano M; Serpa J; Matilde Marques M; Monteiro EC; et al. "Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms.". European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2017): http://europepmc.org/abstract/med/28487145. 10.1016/j.ejps.2017.05.010 Cipriano, Madalena; Pinheiro, Pedro F.; Sequeira, Catarina; Santos, Jorge M.; Oliveira, Nuno G.; Antunes, Alexandra M. M.; Matilde Marques, M.; et al. "3D in vitro cultures of human hepatocyte-like cells as an alternative competent model for nevirapine biotransformation studies". Toxicology Letters (2017): https://publons.com/publon/11121401/. 10.1016/J.TOXLET.2017.07.932 Dias, Clara; Campos, Pedro; Diogo, Lucilia; Trigo, Diva; Correia, Maria Joao; Lemos, Ana; Monteiro, Emilia; Soto, Karina; Pereira, Sofia. "Kidney disease progression in hiv-infected patients related with the detoxification of endogenous electrophilic species". Nephrology Dialysis Transplantation (2017): https://publons.com/publon/28485535/. Pinheiro, Pedro F.; Pereira, Sofia A.; Harjivan, Shrika G.; Martins, Ines L.; Marinho, Aline T.; Cipriano, Madalena; Jacob, Cristina C.; et al. "Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study". Archives of Toxicology (2017): https://publons.com/publon/4396386/. 10.1007/S00204-016-1792-X Pereira, Sofia A.; Ana Godinho; Cristina Jacob; Pereira SA; M. Marques; Alexandra Antunes. "Evidence of bioactivation of the anti-HIV drug etravirine to reactive metabolites in vitro and in vivo". Abstracts of Papers of the American Chemical Society (2017): https://publons.com/publon/18184341/. Nádia M. Grilo; M. João Correia; Catarina Sequeira; Shrika G. Harjivan; Umbelina Caixas; Lucília N. Diogo; M. Matilde Marques; et al. "Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients". Toxicology Letters 260 (2016): 28-35. http://dx.doi.org/10.1016/j.toxlet.2016.08.009. 10.1016/j.toxlet.2016.08.009 Campos, Pedro; Dias, Clara G.; Maia, Sara; Pereira, Sofia Azeredo; Pires, Ana; Soto, Karina. "MP295IS There a role for soluble a-klotho in kidney and immune dysfunction of hiv-infected patients?". Nephrology Dialysis Transplantation 31 suppl_1 (2016): i437-i437. http://dx.doi.org/10.1093/ndt/gfw188.51. 10.1093/ndt/gfw188.51 Aline T. Marinho; Clara G. Dias; Pedro F. Pinheiro; Ana Rita Lemos; Alexandra M.M. Antunes; M. Matilde Marques; Emília C. Monteiro; Joana P. Miranda; Sofia A. Pereira. "Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach". European Journal of Pharmaceutical Sciences 82 (2016): 147-153. http://dx.doi.org/10.1016/j.ejps.2015.11.019. 10.1016/j.ejps.2015.11.019 Pereira, Sofia A.. "S-protein thiol-omics to assess the redox-modulation effects of antiretroviral drugs". Journal of the International AIDS Society (2016): https://publons.com/publon/20372510/. Lopes-Coelho, Filipa; Gouveia-Fernandes, Sofia; Goncalves, Luis G.; Nunes, Carolina; Faustino, Ines; Silva, Fernanda; Felix, Ana; et al. "HNF1 beta drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC)". Tumor Biology 37 4 (2016): 4813-4829. https://publons.com/publon/4386561/. 10.1007/S13277-015-4290-5 Campos, Pedro; Dias, Clara G.; Maia, Sara; Pereira, Sofia Azeredo; Pires, Ana; Soto, Karina. "Is there a role for soluble alpha-klotho in kidney and immune dysfunction of hiv-infected patients?". Nephrology Dialysis Transplantation (2016): https://publons.com/publon/28485536/. Pereira, Sofia A.. "Monitoring of 8-hydroxy-efavirenz concentrations for management of mood changes". Journal of the International AIDS Society (2016): https://publons.com/publon/18184287/. Pereira, Sofia A.; Monteiro, Tiago; Oliveira, Francisco; Fins, Adérito; Dias, Clara G.; Silveira, Célia M.; Pereira, Sofia A.; Almeida, M. Gabriela. "Assessment of human paraoxonase activity by electrochemistry: a simple and novel approach". Analytical Methods 8 46 (2016): 8141-8146. https://publons.com/publon/8939378/. 10.1039/C6AY01944G Pereira, Sofia A.; Maria Correia; Clara Dias; Umbelina Caixas; Nádia Grilo; Ana Lemos; Diva Trigo; et al. "Urinary products of N-acetyltransferase 8 as indicators of kidney disease progression in HIV infection". Journal of the International AIDS Society (2016): https://publons.com/publon/14657360/. 10.7448/IAS.19.8.21487 Diogo, Lucília N.; Pereira, Sofia A.; Nunes, Ana R.; Afonso, Ricardo A.; Santos, Ana I.; Monteiro, Emília C.; Pereira, Sofia A.. "Efficacy of carvedilol in reversing hypertension induced by chronic intermittent hypoxia in rats". European Journal of Pharmacology 765 (2015): 58-67. http://dx.doi.org/10.1016/j.ejphar.2015.08.019. 10.1016/j.ejphar.2015.08.019 Gorgulho, R.; Lopes, S.; Correia, A.C.; Tranfield, E.; Monteiro, E.; Pereira, S.; Morello, J.. "Usefulness of zebrafish model to assess glomerular and tubular alterations induced by nephrotoxic drugs (conference abstract Eurotox 2015)". Toxicology Letters 238 2 (2015): S334. http://dx.doi.org/10.1016/j.toxlet.2015.08.952. 10.1016/j.toxlet.2015.08.952 Harjivan, S.G.; Pinheiro, P.F.; Martins, I.L.; Novais, D.A.; Wanke, R.; Santos, P.P.; Pereira, S.A.; et al. "Enzymatic bioactivation of the phenolic nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine to quinoid intermediates: Covalent adduct formation with nitrogen-based amino acids (asbstract EUROTOX 2015)". Toxicology Letters 238 2 (2015): S359-S360. http://dx.doi.org/10.1016/j.toxlet.2015.08.1025. 10.1016/j.toxlet.2015.08.1025 Dias, C.; Casimiro, N.F.; Maia, S.; Papoila, A.L.; Pereira, S.A.; Soto, K.. "Lactonase activity and kidney function in HIV-infected patients under combined antiretroviral therapy (abstract EUROTOX 2015)". Toxicology Letters 238 2 (2015): S163. http://dx.doi.org/10.1016/j.toxlet.2015.08.503. 10.1016/j.toxlet.2015.08.503 Diogo LN; Faustino IV; Afonso RA; Pereira SA; Monteiro EC; Santos AI; Diogo, Lucilia N.; et al. "Voluntary Oral Administration of Losartan in Rats.". Journal of the American Association for Laboratory Animal Science : JAALAS (2015): http://europepmc.org/abstract/med/26424254. Pereira, S.A.; Antunes, A.M.M.; Dias, C.G.; Marinho, A.T.; Harjivan, S.G.; Fonseca, M.; Maia, S.; et al. "Anti-histone antibodies in HIV-infected patients on Nevirapine-containing antiretroviral therapy (abstract)". Clinical Therapeutics 37 8 (2015): e142. http://dx.doi.org/10.1016/j.clinthera.2015.05.408. 10.1016/j.clinthera.2015.05.408 Pinheiro, P.F.; Marinho, A.T.; Antunes, A.M.M.; Marques, M.M.; Pereira, S.A.; Miranda, J.P.. "Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats". Chemico-Biological Interactions 233 (2015): 115-121. http://dx.doi.org/10.1016/j.cbi.2015.03.024. 10.1016/j.cbi.2015.03.024 Harjivan, Shrika G.; Pinheiro, Pedro F.; Martins, Inês L.; Godinho, Ana L.; Wanke, Riccardo; Santos, Pedro P.; Pereira, Sofia A.; et al. "Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts". Toxicology Research 4 6 (2015): 1565-1577. http://dx.doi.org/10.1039/c5tx00176e. 10.1039/c5tx00176e Dias, C.; Casimiro, N. F.; Maia, S.; Papoila, A. L.; Pereira, S. A.; Soto, K.. "Lactonase activity and kidney function in HIV-infected patients under combined antiretroviral therapy". Toxicology Letters (2015): https://publons.com/publon/20372511/. 10.1016/J.TOXLET.2015.08.503 Harjivan, S. G.; Pinheiro, P. F.; Martins, I. L.; Novais, D. A.; Wanke, R.; Santos, P. P.; Pereira, S. A.; et al. "Enzymatic bioactivation of the phenolic nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine to quinoid intermediates: Covalent adduct formation with nitrogen-based amino acids". Toxicology Letters (2015): https://publons.com/publon/11121391/. 10.1016/J.TOXLET.2015.08.1025 Harjivan, Shrika G.; Pinheiro, Pedro F.; Martins, Ines L.; Godinho, Ana L.; Wanke, Riccardo; Santos, Pedro P.; Pereira, Sofia A.; et al. "Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts". Toxicology Research (2015): https://publons.com/publon/4396382/. 10.1039/C5TX00176E Pereira, S. A.; Antunes, A. M. M.; Dias, C. G.; Marinho, A. T.; Harjivan, S. G.; Fonseca, M.; Maia, S.; et al. "ANTI-HISTONE ANTIBODIES IN HIV-INFECTED PATIENTS ON NEVIRAPINE-CONTAINING ANTIRETROVIRAL THERAPY". Clinical Therapeutics (2015): https://publons.com/publon/11121394/. 10.1016/J.CLINTHERA.2015.05.408 Pinheiro, P. F.; Marinho, A. T.; Antunes, A. M. M.; Marques, M. M.; Pereira, S. A.; Miranda, J. P.. "Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats". Chemico-Biological Interactions (2015): https://publons.com/publon/228820/. 10.1016/J.CBI.2015.03.024 Pereira, Sofia A.; Lucilia Diogo; Pereira SA; Ana R. Nunes; Ricardo A. Afonso; Ana Isabel Santos; E.C. Monteiro; et al. "Hypertension induced by chronic intermittent hypoxia: Effects of carvedilol in a rat model". European Respiratory Journal (2015): https://publons.com/publon/20372512/. 10.1183/13993003.CONGRESS-2015.OA294 Marinho, Aline; Dias, Clara; Antunes, Alexandra; Caixas, Umbelina; Branco, Teresa; Marques, Matilde; Monteiro, Emília; Pereira, Sofia. "Sex differences in apolipoprotein A1 and nevirapine-induced toxicity (Abstracts of the HIV DrugTherapy Glasgow Congress 2014)". Journal of the International AIDS Society 17 (2014): 19575. http://dx.doi.org/10.7448/ias.17.4.19575. 10.7448/ias.17.4.19575 Dias C; Marinho A; Morello J; Almeida G; Caixas U; Soto K; Monteiro E; et al. "Monitoring of the lactonase activity of paraoxonase-1 enzyme in HIV-1-infection.". Journal of the International AIDS Society 17 (2014): 19682. http://europepmc.org/abstract/med/25397432. 10.7448/IAS.17.4.19682 Marinho A; Dias C; Antunes A; Caixas U; Branco T; Marques M; Monteiro E; Pereira S. "Sex differences in apolipoprotein A1 and nevirapine-induced toxicity.". Journal of the International AIDS Society (2014): http://europepmc.org/abstract/med/25394082. 10.7448/IAS.17.4.19575 Afonso, Lara P.; Dias, Clara G.; Marinho, Aline T.; Esteves, Adriana; Jacinto, Ana R.; Pintado, Petra; Lopes, Susana S.; et al. "Paraoxonase as part of endogenous free-radical scavenging system in zebrafish (abstract EUROTOX 2014)". Toxicology Letters 229 (2014): S41. https://doi.org/10.1016/j.toxlet.2014.06.185. 10.1016/j.toxlet.2014.06.185 Dias, Clara G.; Marinho, Aline T.; Caixas, Umbelina; Faustino, Inês; Antunes, Alexandra M.M.; Marques, M. Matilde; Monteiro, Emília C.; Pereira, Sofia A.. "Thiol status in HIV-infected patients: The effect of nevirapine metabolism (abstract EUROTOX 2014)". Toxicology Letters 229 (2014): S95. http://dx.doi.org/10.1016/j.toxlet.2014.06.352. 10.1016/j.toxlet.2014.06.352 Diogo, Lucilia; Faustino, Inês; Afonso, Ricardo; Pereira, Sofia; Monteiro, Emilia; Santos, Ana. "Oral voluntary ingestion as a stress free alternative to orogastric gavage: The example of losartan chronic administration (abstract EUROTOX 2014)". Toxicology Letters 229 (2014): S166-S167. http://dx.doi.org/10.1016/j.toxlet.2014.06.572. 10.1016/j.toxlet.2014.06.572 Pinheiro, Pedro F.; Marinho, Aline T.; Antunes, Alexandra M.M.; Marques, M. Matilde; Castro, Matilde F.; Pereira, Sofia A.; Miranda, Joana P.. "Sex differences in hepatic and intestinal contributions for nevirapine biotransformation (abstract EUROTOX 2014)". Toxicology Letters 229 (2014): S240-S241. http://dx.doi.org/10.1016/j.toxlet.2014.06.803. 10.1016/j.toxlet.2014.06.803 Grilo, Nádia M.; Batalha, Vânia L.; Lopes, Luisa V.; Marques, M. Matilde; Monteiro, Emília C.; Antunes, Alexandra M.M.; Pereira, Sofia A.. "An animal model to explore efavirenz toxicokinetics and its relation to neurological phenotype (abstract EUROTOX 2014)". Toxicology Letters 229 (2014): S244. http://dx.doi.org/10.1016/j.toxlet.2014.06.813. 10.1016/j.toxlet.2014.06.813 Marinho, Aline T.; Dias, Clara G.; Pinheiro, Pedro F.; Antunes, Alexandra M.M.; Marques, M. Matilde; Monteiro, Emília C.; Miranda, Joana P.; Pereira, Sofia A.. "PON-1 activity as a protective player in nevirapine hepatotoxicity: Data comparison in 2D and 3D cell cultures (abstract EUROTOX 2014)". Toxicology Letters 229 (2014): S134-S135. http://dx.doi.org/10.1016/j.toxlet.2014.06.476. 10.1016/j.toxlet.2014.06.476 Grilo, Nádia M.; Charneira, Catarina; Pereira, Sofia A.; Monteiro, Emília C.; Marques, M. Matilde; Antunes, Alexandra M.M.. "Bioactivation to an aldehyde metabolite—Possible role in the onset of toxicity induced by the anti-HIV drug abacavir". Toxicology Letters 224 3 (2014): 416-423. http://dx.doi.org/10.1016/j.toxlet.2013.10.036. 10.1016/j.toxlet.2013.10.036 Marinho, Aline T.; Godinho, Ana L. A.; Novais, David A.; Antunes, Alexandra M. M.; Marques, M. Matilde; Ramos, Teresa; Dias, Clara G.; Monteiro, Emília C.; Pereira, Sofia A.. "Development and validation of an HPLC-UV method for quantifying nevirapine and its main phase I metabolites in human blood". Analytical Methods 6 5 (2014): 1575. http://dx.doi.org/10.1039/c3ay41911h. 10.1039/c3ay41911h Dias, Clara G.; Batuca, Joana R.; Marinho, Aline T.; Caixas, Umbelina; Monteiro, Emília C.; Antunes, Alexandra M. M.; Pereira, Sofia A.. "Quantification of the arylesterase activity of paraoxonase-1 in human blood". Anal. Methods 6 1 (2014): 289-294. http://dx.doi.org/10.1039/c3ay41527a. 10.1039/c3ay41527a Pereira, Sofia A.. "An animal model to explore efavirenz toxicokinetics and its relation to neurological phenotype". Toxicology Letters (2014): https://publons.com/publon/11121372/. 10.1016/J.TOXLET.2014.06.813 Pereira, Sofia A.. "Oral voluntary ingestion as a stress free alternative to orogastric gavage: The example of losartan chronic administration". Toxicology Letters (2014): https://publons.com/publon/20372513/. 10.1016/J.TOXLET.2014.06.572 Dias, Clara G.; Marinho, Aline T.; Caixas, Umbelina; Faustino, Ines; Antunes, Alexandra M. M.; Matilde Marques, M.; Monteiro, Emilia C.; Pereira, Sofia A.. "Thiol status in HIV-infected patients: The effect of nevirapine metabolism". Toxicology Letters (2014): https://publons.com/publon/11121375/. 10.1016/J.TOXLET.2014.06.352 Marinho, Aline T.; Dias, Clara G.; Pinheiro, Pedro F.; Antunes, Alexandra M. M.; Matilde Marques, M.; Monteiro, Emilia C.; Miranda, Joana P.; Pereira, Sofia A.. "PON-1 activity as a protective player in nevirapine hepatotoxicity: Data comparison in 2D and 3D cell cultures". Toxicology Letters (2014): https://publons.com/publon/5063325/. 10.1016/J.TOXLET.2014.06.476 Marinho, Aline T.; Godinho, Ana L. A.; Novais, David A.; Antunes, Alexandra M. M.; Matilde Marques, M.; Ramos, Teresa; Dias, Clara G.; Monteiro, Emilia C.; Pereira, Sofia A.. "Development and validation of an HPLC-UV method for quantifying nevirapine and its main phase I metabolites in human blood". Analytical Methods (2014): https://publons.com/publon/4396366/. 10.1039/C3AY41911H Pinheiro, Pedro F.; Marinho, Aline T.; Antunes, Alexandra M. M.; Matilde Marques, M.; Castro, Matilde F.; Pereira, Sofia A.; Miranda, Joana P.. "Sex differences in hepatic and intestinal contributions for nevirapine biotransformation". Toxicology Letters (2014): https://publons.com/publon/5063382/. 10.1016/J.TOXLET.2014.06.803 Dias, Clara G.; Batuca, Joana R.; Marinho, Aline T.; Caixas, Umbelina; Monteiro, Emilia C.; Antunes, Alexandra M. M.; Pereira, Sofia A.. "Quantification of the arylesterase activity of paraoxonase-1 in human blood". Analytical Methods (2014): https://publons.com/publon/4396365/. 10.1039/C3AY41527A Harjivan, Shrika G.; Charneira, Catarina; Pereira, Sofia A.; Espadas, Guadalupe; Sabido, Eduard; Beland, Frederick A.; Matilde Marques, M.; Antunes, Alexandra M. M.; Pereira SA. "Covalent histone modification by nevirapine: Potential association with non-AIDS defining cancers". Abstracts of Papers of the American Chemical Society (2014): https://publons.com/publon/10388528/. Afonso, Lara P.; Dias, Clara G.; Marinho, Aline T.; Esteves, Adriana; Jacinto, Ana R.; Pintado, Petra; Lopes, Susana S.; et al. "Paraoxonase as part of endogenous free-radical scavenging system in zebrafish". Toxicology Letters (2014): https://publons.com/publon/13118814/. 10.1016/J.TOXLET.2014.06.185 Wanke, Riccardo; Harjivan, Shrika G.; Pereira, Sofia A.; Marques, M. Matilde; Antunes, Alexandra M.M.. "The role of competitive binding to human serum albumin on efavirenz–warfarin interaction: a nuclear magnetic resonance study". International Journal of Antimicrobial Agents 42 5 (2013): 443-446. http://dx.doi.org/10.1016/j.ijantimicag.2013.06.023. 10.1016/j.ijantimicag.2013.06.023 Marinho, A. T.; Rodrigues, P. M.; Caixas, U.; Antunes, A. M. M.; Branco, T.; Harjivan, S. G.; Marques, M. M.; Monteiro, E. C.; Pereira, S. A.. "Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions". Journal of Antimicrobial Chemotherapy 69 2 (2013): 476-482. http://dx.doi.org/10.1093/jac/dkt359. 10.1093/jac/dkt359 Miranda, J.P.; Pinheiro, P.F.; Marinho, A.T.; Harjivan, S.G.; Castro, M.; Pereira, S.A.; Antunes, A.M.M.; Marques, M.M.. "3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity (abstract EUROTOX 2013)". Toxicology Letters 221 (2013): S174. http://dx.doi.org/10.1016/j.toxlet.2013.05.384. 10.1016/j.toxlet.2013.05.384 Grilo, Nádia M.; Antunes, Alexandra M.M.; Caixas, Umbelina; Marinho, Aline T.; Charneira, Catarina; Conceição Oliveira, M.; Monteiro, Emília C.; Matilde Marques, M.; Pereira, Sofia A.. "Monitoring abacavir bioactivation in humans: Screening for an aldehyde metabolite". Toxicology Letters 219 1 (2013): 59-64. http://dx.doi.org/10.1016/j.toxlet.2013.02.021. 10.1016/j.toxlet.2013.02.021 Kromdijk, W.; Pereira, S.A.; Rosing, H.; Mulder, J.W.; Beijnen, J.H.; Huitema, A.D.R.. "Development and validation of an assay for the simultaneous determination of zidovudine, abacavir, emtricitabine, lamivudine, tenofovir and ribavirin in human plasma using liquid chromatography–tandem mass spectrometry". Journal of Chromatography B 919-920 (2013): 43-51. http://dx.doi.org/10.1016/j.jchromb.2013.01.005. 10.1016/j.jchromb.2013.01.005 Miranda, J. P.; Pinheiro, P. F.; Marinho, A. T.; Harjivan, S. G.; Castro, M.; Pereira, S. A.; Antunes, A. M. M.; Marques, M. M.. "3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity". Toxicology Letters (2013): https://publons.com/publon/5063334/. 10.1016/J.TOXLET.2013.05.384 Marinho, A. T.; Antunes, A. M. M.; Caixas, U.; Branco, T.; Godinho, A. L. A.; Oliveira, M. C.; Marques, M. M.; et al. "Haptenation of the antiretroviral drug nevirapine upon bioactivation in man". PROCEEDINGS OF THE 6TH EUROPEAN CONGRESS OF PHARMACOLOGY (2013): 155-158. https://publons.com/publon/11121354/. 10.1016/j.tox.2012.06.013 Charneira, Catarina; Pereira, Sofia A.; Antunes, Alexandra M. M.; Matilde Marques, M.; Catarina Charneira; Pereira SA; Alexandra M. M. Antunes; M. Matilde Marques. "Estrogen-induced systemic lupus erythematosus: Understanding the role of protein adducts in autoimmunity". Abstracts of Papers of the American Chemical Society (2013): https://publons.com/publon/11121338/. Caixas, Umbelina; Antunes, Alexandra M.M.; Marinho, Aline T.; Godinho, Ana L.A.; Grilo, Nádia M.; Marques, M. Matilde; Oliveira, M. Conceição; et al. "Evidence for nevirapine bioactivation in man: Searching for the first step in the mechanism of nevirapine toxicity". Toxicology 301 1-3 (2012): 33-39. http://dx.doi.org/10.1016/j.tox.2012.06.013. 10.1016/j.tox.2012.06.013 Charneira, C; Grilo, NM; Pereira, SA; Godinho, ALA; Monteiro, EC; Marques, MM; Antunes, AMM. "N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehydein vivo". British Journal of Pharmacology 167 6 (2012): 1353-1361. http://dx.doi.org/10.1111/j.1476-5381.2012.02079.x. 10.1111/j.1476-5381.2012.02079.x Caixas, U.; Ferreira, J.; Marinho, A. T.; Faustino, I.; Grilo, N. M.; Lampreia, F.; Germano, I.; Monteiro, E. C.; Pereira, S. A.. "Long-term maraviroc use as salvage therapy in HIV-2 infection". Journal of Antimicrobial Chemotherapy 67 10 (2012): 2538-2539. http://dx.doi.org/10.1093/jac/dks240. 10.1093/jac/dks240 Pereira, S.A.; Wanke, R.; Marques, M.M.; Monteiro, E.C.; Antunes, A.M.M.. "Insights into the role of bioactivation mechanisms in the toxic events elicited by non-nucleoside reverse transcriptase inhibitors". Advances in Molecular Toxicology 6 (2012): 1-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865355478&partnerID=MN8TOARS. 10.1016/B978-0-444-59389-4.00001-X Grilo, Nadia M.; Antunes, Alexandra M. M.; Caixas, Umbelina; Gouveia, Sandra; Conceicao Oliveira, M.; Marinho, Aline T.; Monteiro, Emilia C.; Matilde Marques, M.; Pereira, Sofia A.. "Hemoglobin adducts from the antiretroviral abacavir in HIV-infected patients as evidence of bioactivation". Abstracts of Papers of the American Chemical Society (2012): https://publons.com/publon/11121320/. Charneira, Catarina; Godinho, Ana L. A.; Oliveira, M. Conceição; Pereira, Sofia A.; Monteiro, Emília C.; Marques, M. Matilde; Antunes, Alexandra M. M.. "Reactive Aldehyde Metabolites from the Anti-HIV Drug Abacavir: Amino Acid Adducts as Possible Factors in Abacavir Toxicity". Chemical Research in Toxicology 24 12 (2011): 2129-2141. http://dx.doi.org/10.1021/tx200337b. 10.1021/tx200337b Antunes, Alexandra M. M.; Godinho, Ana L. A.; Pereira, Sofia A.; Surratt, Gordon; da Costa, Goncalo Gamboa; Beland, Frederick A.; Matilde Marques, M.. "Nevirapine metabolism to 4-formyl-nevirapine: Possible role in nevirapine toxicity". Abstracts of Papers of the American Chemical Society (2011): https://publons.com/publon/11121358/. Pereira, S. A.; Batuca, J. R.; Caixas, U.; Branco, T.; Delgado-Alves, J.; Germano, I.; Lampreia, F.; Monteiro, E. C.. "Effect of efavirenz on high-density lipoprotein antioxidant properties in HIV-infected patients". British Journal of Clinical Pharmacology 68 6 (2009): 891-897. http://dx.doi.org/10.1111/j.1365-2125.2009.03535.x. 10.1111/j.1365-2125.2009.03535.x Pereira, Sofia A.; Caixas, Umbelina; Branco, Teresa; Germano, Isabel; Lampreia, Fátima; Papoila, Ana L.; Monteiro, Emília C.. "Efavirenz concentrations in HIV-infected patients with and without viral hepatitis". British Journal of Clinical Pharmacology 66 4 (2008): 551-555. http://dx.doi.org/10.1111/j.1365-2125.2008.03238.x. 10.1111/j.1365-2125.2008.03238.x Pereira, Sofia A; Branco, Teresa; Caixas, Umbelina; Côrte-Real, Rita M; Germano, Isabel; Lampreia, Fátima; Monteiro, Emília C. "Intra-Individual Variability in Efavirenz Plasma Concentrations Supports Therapeutic Drug Monitoring Based on Quarterly Sampling in the First Year of Therapy". Therapeutic Drug Monitoring 30 1 (2008): 60-66. http://dx.doi.org/10.1097/ftd.0b013e318160ce76. 10.1097/ftd.0b013e318160ce76 Pereira SA; Teresa Branco; Umbelina Caixas; Rita M. Corte-Real; Isabel Germano; Fátima Lampreia; E.C. Monteiro. "Intra-individual variability in efavirenz plasma concentrations supports therapeutic, drug monitoring based on quarterly sampling in the first year of therapy". Therapeutic Drug Monitoring 30 1 (2008): 60-66. https://novaresearch.unl.pt/en/publications/8b1a93ad-17ae-4f01-9fd0-fdf9f8ea0599. 10.1097/FTD.0b013e318160ce76 Pereira, SA; Batuca, J; Caixas, U; Branco, T; Germano, I; Lampreia, F; Delgado-Alves, J; Monteiro, EC. "HIV and antioxidant lipoprotein-associated effect. Is there a correlation?". Journal of the International AIDS Society 11 Suppl 1 (2008): P96-P96. http://dx.doi.org/10.1186/1758-2652-11-S1-P96. 10.1186/1758-2652-11-s1-p96 Carneiro, Fernando F.; Oliveira, Mara Lúcia C.; Netto, Guilherme F.; Galvão, Luis A.C.; Cancio, Jacira A.; Bonini, Estela M.; Corvalan, Carlos F.. "Meeting Report: Development of Environmental Health Indicators in Brazil and Other Countries in the Americas". Environmental Health Perspectives 114 9 (2006): 1407-1408. http://dx.doi.org/10.1289/ehp.8486. 10.1289/ehp.8486 Pereira, Sofia A.; Branco, Teresa; Corte-Real, Rita M.; Germano, Isabel; Lampreia, Fatima; Caixas, Umbelina; Monteiro, Emilia C.. "Long-term and concentration-dependent beneficial effect of efavirenz on HDL-cholesterol in HIV-infected patients". British Journal of Clinical Pharmacology 61 5 (2006): 601-604. http://dx.doi.org/10.1111/j.1365-2125.2006.02619.x. 10.1111/j.1365-2125.2006.02619.x Pereira, S. A.; Corte-Real, R. M.; Branco, T.; Germano, I.; Lampreia, F.; Caixas, U.; Monteiro, E. C.. "Target plasma concentration for efavirenz in HIV-infected patients". Fundamental & Clinical Pharmacology (2004): https://publons.com/publon/28485541/.
Artigo em revista (magazine)	Pereira, Sofia A.; Pereira, Sofia. "Estudos de iniciativa do investigador nas estratégias de otimização terapêutica.", Revista "O Hospital", 2017, https://issuu.com/apdhpublicacoes/docs/revista-hospital-x.
Capítulo de livro	Clara Gonçalves-Dias; Catarina O. Sequeira; João Vicente; M. João Correia; Nuno R. Coelho; Judit Morello; AMM Antunes; et al. "A Mechanistic-Based and Non-invasive Approach to Quantify the Capability of Kidney to Detoxify Cysteine-Disulfides". 109-120. Springer, 2021. 10.1007/978-3-030-63908-2_8 João Filipe Raposo; José A. Belo; Sílvia V. Conde; Monteiro, EC; José Silva Nunes; Pereira, Sofia A.; Gabriela A. Silva; Maria Paula Macedo. "B From a classical to a new nova perspective on cardiometabolic diseases". In From Life Molecules to Global Health, 261-290. PRINCIPIA, 2021. Publicado Coelho, Nuno R.; Dias, Clara G.; João Correia, M.; Grácio, Patrícia; Serpa, Jacinta; Monteiro, Emília C.; Diogo, Lucília N.; Pereira, Sofia A.. "Cysteine Oxidative Dynamics Underlies Hypertension and Kidney Dysfunction Induced by Chronic Intermittent Hypoxia". In Advances in Experimental Medicine and Biology, 83-88. Springer International Publishing, 2018. 10.1007/978-3-319-91137-3_10 Pereira, Sofia A.; Wanke, Riccardo; Marques, M. Matilde; Monteiro, Emília C.; Antunes, Alexandra M.M.. "Insights into the Role of Bioactivation Mechanisms in the Toxic Events Elicited by Non-nucleoside Reverse Transcriptase Inhibitors". In Advances in Molecular Toxicology Volume 6, 1-39. Elsevier, 2012. 10.1016/b978-0-444-59389-4.00001-x Pereira, Sofia A.. "HDL in HIV infection: the effect of the antiretroviral efavirenz on HDL-quality and quantity.". In Advances in medicine and biology. Nova Science Publishers, Inc, 2012. Publicado "Understanding the Molecular Basis for the Hazards Associated with Nevirapine Treatment, in: L.V". In Advances in Medicine and Biology. NovaPublishers, 2012. Publicado
Poster em conferência	Marto, Natália; Morello, Judit; Antunes, AMM; Monteiro, EC; Pereira, Sofia A.. "Phenotyping SULT in Man: a Simple Metric Using Paracetamol as Probe". Trabalho apresentado em ASPET Annual Meeting at EB 2021, 2021. Correia, M João; Coelho, Nuno; Elsa Mecha; Sandra Silva; Bronze, Maria; Monteiro, EC; Pereira, Sofia A.. "Olive oil and arterial hypertension (htn): a focus on hydroxytyrosol". Trabalho apresentado em II Conference NOVASaude Nutrition, 2021. Branco, Patrícia; Martins, Ana Rita Mateus; Coelho, Rita Alexandre; Pinto, Daniel G; Mateus, Catarina; Calça, Rita; Sequeira CO; Morello, Judit; Pereira, Sofia A.. "A Pilot Evaluation of Thiol Metabolome in Peritoneal Dialysate as an Indicator of Peritoneal Fibrosis (PO1247)". Trabalho apresentado em Kidney Week 2020, 2020. Fernandes D.G.H.; Coelho N.R.; Correia, M João; Tomé C.S.; Sequeira CO; Monteiro, EC; Matias P.M.; Pereira, Sofia A.; Vicente, João B.. "The six W´s of protein cysteinylation in the kidney.". Trabalho apresentado em 10th ITQB NOVA PhD Students Meeting, 2020. Judit Morello; Sara M. Teixeira; Joao Rodrigues; Sara Maia; Atlas Sardoo; Rita Pinheiro Torres; Pereira SA; et al. "Diagnosis of Inflammatory Rheumatic Diseases: Preliminary Approach by Urine Metabolomics". Trabalho apresentado em Annual Meeting of the American College of Rheumatology, 2019. Pereira, Sofia. "Blockade of AhR reverts systemic hypertension induced by chronic intermittent hypoxia in rats". Trabalho apresentado em AhR Meeting, Paris, France, 2018. Pereira, Sofia. "Renal cysteine-disulfide stress is a common feature of cardiometabolic diseases". Trabalho apresentado em I NoTeS Congress – Novel Therapeutic Strategies for Noncommunicable Diseases, Porto, Portugal, 2018. Pereira, Sofia. "Mercapturates of cysteine-S-disulfides in kidney dysfunction in HIV-infection". Trabalho apresentado em 1st Workshop on Human Biomonitoring in Portugal (1st HBM-PT), Lisbon, Portugal, 2018. Pereira, Sofia. "Mercapturates of cysteine-S-disulfides for risk assessment of exposure-related hypertension and kidney dysfunction". Trabalho apresentado em DiMoPEx Working Groups Meeting, 2nd International conference on Pollution in living and working environments and health, Bentivoglio, Italy, 2017. https://www.journalhealthpollution.org/doi/pdf/10.5696/2156-9614.8.17.1 Pereira, Sofia. "Mercapturate pathway and kidney disease progression in HIV-patients: a 1-year prospective study". Trabalho apresentado em ISN World Congress of Nephrology 2017, México., 2017. Nádia Grilo; Maria Correia; Catarina Sequeira; Shrika G Harjivan; Umbelina Caixas; Lucilia Diogo; M Matilde Marques; et al. "Monitoring of 8-hydroxy-efavirenz concentrations for management of mood changes". Trabalho apresentado em International Congress of Drug Therapy in HIV Infection, Glasgow, 2016. http://dx.doi.org/10.7448/IAS.19.8.21487 Pereira, Sofia. "S-protein thiol-omics to assess the redox-modulation effects of antiretroviral drugs". Trabalho apresentado em International Congress of Drug Therapy in HIV Infection, Glasgow, 2016. 10.7448/IAS.19.8.21487
Recurso online	Pereira, Sofia. Zebrafish is an attractive model to anticipate drug-induced renal injury in humans.. 2018. https://atlasofscience.org/zebrafish-is-an-attractive-model-to-anticipate-drug-induced-renal-injury-in-humans/.
Resumo em conferência	Pereira, Sofia. "The antihypertensive effect of ahr antagonist is related to circadian variation of blood pressure in chronic intermittent hypoxia condition [oral presentation]". Trabalho apresentado em L Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVIII Reunião de Farmacologia Clínica/ XIX Reunião de Toxicologia, Coimbra, 2020. Pereira, Sofia. "Hydroxytyrol prevents increase in systolic blood pressure induced by chronic intermittent hypoxia [oral presentation]". Trabalho apresentado em XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVII Reunião de Farmacologia Clínica/ XVIII Reunião de Toxicologia, Porto, 2019. Pereira, Sofia. "Pharmacological blocking of AhR reduces hypertension induced by chronic intermittent hypoxia [oral presentation]". Trabalho apresentado em XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVII Reunião de Farmacologia Clínica/ XVIII Reunião de Toxicologia, Porto, 2019. Pereira, Sofia. "Urinary mercapturates of cysteine-disulfides decrease in models of drug-induced acute kidney injury [oral presentation]". Trabalho apresentado em XLIX Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVII Reunião de Farmacologia Clínica/ XVIII Reunião de Toxicologia, Porto, 2019. Pereira, Sofia. "Metabolomics of drug-induced renal injury in zebrafish larvae. [oral presentation]". Trabalho apresentado em XLVII meeting of thePortuguese Society of Pharmacology, 2018. Pereira, Sofia. "Enzymes involved in cysteine metabolism underlie hypoxia adaptation in ovarian cancer [oral presentation]". Trabalho apresentado em 8th International conference on Tumor Microenvironment, 2018. 10.1007/s12307-018-0212-6 Pereira, Sofia. "Mercapturatos de dissulfetos de cisteína como marcadores de progressão de doença renal: comparação entre dois modelos animais de pré-diabetes [oral presentation]". Trabalho apresentado em 14º Congresso Português de Diabetes (Rev Port Diab 2018, 13(1) Suppl:37-40), 2018. Pereira, Sofia. "AhR: linking environmental exposure and sleep apnea to improve arterial hypertension management [oral presentation]". Trabalho apresentado em I NoTeS Congress – Novel Therapeutic Strategies for Noncommunicable Diseases, Porto, 2018. Pereira, Sofia. "Cysteine disulfide stress is a common mechanism in kidney injury associated to metabolic inflammation models [oral communication]". Trabalho apresentado em XXXI Congresso Português de Nefrologia, Vilamoura, 2018. Pereira, Sofia. "Cysteine oxidative dynamics underlies hypertension and kidney dysfunction induced by chronic intermittent hypoxia [oral presentation]". Trabalho apresentado em XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVI Reunião de Farmacologia Clínica/ XVII Reunião de Toxicologia, Lisbon, 2018. Pereira, Sofia. "AhR metabolic pathway in hypertension induced by chronic intermittent hypoxia [oral presentation]". Trabalho apresentado em XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVI Reunião de Farmacologia Clínica/ XVII Reunião de Toxicologia, Lisbon, 2018. Pereira, Sofia. "Effect of chronic intermittent hypoxia in the temporal variation of mercapturates of cysteineS-disulfides [oral presentation]". Trabalho apresentado em XLVIII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVI Reunião de Farmacologia Clínica/ XVII Reunião de Toxicologia, Lisbon, 2018. Pereira, Sofia. "Is zebrafish a good model to assess drug-induced renalinjury? [inivited oral presentation]". Trabalho apresentado em 3rd InternationalConference on Urine Omics and 2nd International Caparica Conference inTranslational Nephrology, 2017. Pereira, Sofia. "Comparison of a marker of kidney disease progression between two animal models of pre-diabetes [oral presentation]". Trabalho apresentado em Renal disease in obesity and diabetes. Advances in pathogenesis and therapeutics – Diabesity Working Group, Lisbon, 2017. Pereira, Sofia. "Cysteine oxidation in kidney: the effect of short and long-term exposure to chronic intermittent hypoxia [1 minute elevator talk]". Trabalho apresentado em EMBO Workshop: Thiol oxidation in toxicity and signaling, Sant Feliu de Guïxols, 2017. Pereira, Sofia. "Cysteine oxidation in the underlying mechanisms of kidney fibrosis induced by chronic intermittent hypoxia [oral presentation]". Trabalho apresentado em XXth Meeting of the International Society of Arterial Chemoreception (ISAC), Baltimore, 2017. Pereira, Sofia. "S-thiolated protein profile is influenced by efavirenz [oral presentation]". Trabalho apresentado em XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXV Reunião de Farmacologia Clínica/ XVI Reunião de Toxicologia, Coimbra, 2017. Pereira, Sofia. "Temporal and tissue dependent effects of Efavirenz exposure: implications for its neurotoxicity [oral presentation]". Trabalho apresentado em XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXV Reunião de Farmacologia Clínica/ XVI Reunião de Toxicologia, Coimbra, 2017. Pereira, Sofia. "uNAC as a novel marker of kidney disease progression in HIV-patients [oral presenation]". Trabalho apresentado em XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXV Reunião de Farmacologia Clínica/ XVI Reunião de Toxicologia, Coimbra, 2017. Pereira, Sofia. "Kidney cysteine redox cycle in rats exposed to chronic intermittent hypoxia [oral presentation]". Trabalho apresentado em XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXV Reunião de Farmacologia Clínica/ XVI Reunião de Toxicologia, Coimbra, 2017. Pereira, Sofia. "Molecular targeting of proteins by homocysteine in hypercholesterolemia [oral presentation]". Trabalho apresentado em . XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXIII Reunião de Farmacologia Clínica/ XV Reunião de Toxicologia, 2016. Pereira, Sofia. "Modulation of paraoxonase-1 by nevirapine: comparison between three in vitro models [oral presentation]". Trabalho apresentado em XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXIII Reunião de Farmacologia Clínica/ XV Reunião de Toxicologia, 2016. Pereira, Sofia. "Urinary N-acetylated cysteine-disulfides as indicators of kidney disease progression in HIV-infected patients [oral presentation]". Trabalho apresentado em 7th European Congress of Pharmacology (EPHAR), 2016. Pereira, Sofia. "Efavirenz biotransformation at the onset of mood changes in HIV-infected male patients [oral presentation]". Trabalho apresentado em XLVI Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXIV Reunião de Farmacologia Clínica/ XV Reunião de Toxicologia, Porto, 2016. Pereira, Sofia. "Monitoring glomerular function in zebrafish larvae (Danio rerio) exposed to nephrotoxic drugs. [oral presentation]". Trabalho apresentado em XLV meeting of the Portuguese Society of Pharmacology, 2015. Pereira, Sofia. "The role of Nevirapine phase I metabolites in the renal function of HIV-infected patients [oral presentation]". Trabalho apresentado em 1st International Caparica Conference in Translational Nephrology & 18th Portuguese Symposium on Renal Diseases, 2014. Pereira, Sofia. "Antivíricos diretos e imunossupressores: interações [invited oral presentation]". Trabalho apresentado em Workshop Hepatite C - Inovação Farmacologia e Transplantação, 2014. Pereira, Sofia A.. "Thiol status in HIV-infected patients: the effect of nevirapine metabolism.". 2014. DOI: 10.1016/j.toxlet.2014.06.352 Pereira, Sofia A.. "PON-1 activity as a protective player in nevirapine hepatotoxicity: data comparison in 2D and 3D cell cultures.". 2014. DOI: 10.1016/j.toxlet.2014.06.476 Pereira, Sofia A.. "Paraoxonase as part of endogenous free-radical scavenging system in zebrafish". 2014. DOI: 10.1016/j.toxlet.2014.06.185 Pereira, Sofia A.; Inês Varanda de Jesus Faustino; Lucilia Diogo; Ricardo A. Afonso; Pereira SA; E.C. Monteiro; Ana Isabel Santos. "Oral voluntary ingestion as a stress free alternative to orogastric gavage: The example of losartan chronic administration.". 2014. DOI: 10.1016/j.toxlet.2014.06.572 Pereira, Sofia A.. "3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity.". Trabalho apresentado em 49th Congress of the European Societies of Toxicology (EUROTOX), 2013. Pereira, Sofia. "Relevance of CYP2C19 genotypes in Nevirapine biotransformation [oral presentation]". Trabalho apresentado em European Society of Pharmacogenomics and Theranostics (ESPT) Second Conference. Pharmacogenomics: from Cell to Clinic, 2013. Pereira, Sofia. "Effect of chronic exposure to the antiretroviral drug nevirapine on paraoxonase-1 activities in HIV-infected patients [oral presentation]". Trabalho apresentado em 2nd International Conference on Occupational & Environmental Toxicology, 2013. Pereira, Sofia. "Biomedical models for translational research [invited oral presentation]". Trabalho apresentado em 3º Congresso Internacional de Enfermagem Veterinária, 2013. Pereira SA; E.C. Monteiro. "Hemoglobin adducts from the antiretroviral abacavir in HIV-infected patients as evidence of bioactivation [oral presentation]". Trabalho apresentado em 244th ACS National Meeting & Exposition, Philadelphia, 2012. Pereira, Sofia. "Antiretrovirals and Cardiovascular disease [invited oral presentation]". Trabalho apresentado em Santa Marta Lisbon Summer Meeting, 2012.
Tese / Dissertação	Pereira, Sofia de Azeredo. "Drug Monitoring of Efavirenz -applicability criteria and long-term pharmacokinetic/pharmacodynamic relations". Doutoramento, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2009. http://hdl.handle.net/10362/5210.

Propriedade Intelectual

Patente

Pereira, Sofia A.; Maria Emilia Carreira Saraiva Monteiro (5918-54A6-FAA0); Aline Teixeira Marinho. 2019. "2-hydroxy-nevirapine analogues or derivatives for use in the treatment of diseases related to high density lipoprotein dysfunction. PPI 2019/20066".

Outros

Outra produção

Association Between Sarcopenia, Body Composition and Frailty in Peritoneal Dialysis Patients. A Multi-centric Study. 2023. MNP Mauricio; JH Merino; A Carnevale; Pereira SA; AR Martins; R Calça; P Matias; et al. https://novaresearch.unl.pt/en/publications/6b8ce74c-378b-4637-9ec0-c8c793d43f26.
"surprise Question". Is It a Useful Tool in Ckd Stages 4 to 5?. 2023. B Pepe; T Prazeres; A Carnevale; R Calca; P Matias; P Branco; Sofia Mucharreira de Azeredo Lopes; Pereira SA; AR Martins. https://novaresearch.unl.pt/en/publications/c5708652-627f-428a-a4b6-ae62ba4053fa.
Aryl hydrocarbon receptor antagonists - a new entry in antihypertensive armamentarium of obstructive sleep apnea?. 2021. Pereira SA; Nuno R. Coelho; Celine Tomkiewcz; Maria Joao Correia; Antonio B. Pimpao; Robert Barouki; Xavier Coumoul; et al. https://novaresearch.unl.pt/en/publications/53cdf1c1-8bfa-4732-8d69-e835b48bc6ce.
Platelet-lymphocyte ratio as a short-term treatment-response predictor in schizophrenia's relapse. 2019. Ines Carreira Figueiredo; Ines Cargaleiro; Stephanie Mueller; Aguiar P.; Joana R Batuca; Pereira SA; Lucilia Diogo; Ilinca Ureche-Angelescu; E.C. Monteiro. https://novaresearch.unl.pt/en/publications/6527fc22-da62-4659-b971-73837deba614.
KIDNEY DISEASE PROGRESSION IN HIV-INFECTED PATIENTS RELATED WITH THE DETOXIFICATION OF ENDOGENOUS ELECTROPHILIC SPECIES. 2017. Clara Dias; Pedro Campos; Lucilia Diogo; Diva Trigo; Maria Joao Correia; Ana Lemos; E.C. Monteiro; Karina Soto; Pereira SA. https://novaresearch.unl.pt/en/publications/c0be8f8e-d7bc-42e4-b0a4-96dc01936af1.
Monitoring of 8-hydroxy-efavirenz concentrations for management of mood changes. 2016. Nádia Grilo; Maria Correia; Catarina Sequeira; Shrika G Harjivan; Umbelina Caixas; Lucilia Diogo; M Matilde Marques; et al. https://novaresearch.unl.pt/en/publications/d64cf9ee-431f-450a-bb5c-006a503625a9.
IS THERE A ROLE FOR SOLUBLE alpha-KLOTHO IN KIDNEY AND IMMUNE DYSFUNCTION OF HIV-INFECTEDPATIENTS?. 2016. Pedro Campos; Clara G Dias; Sara Maia; Pereira SA; Ana Pires; Karina Soto. https://novaresearch.unl.pt/en/publications/44bffc04-8162-4488-917c-efcadf40539d.
Sex differences in hepatic and intestinal contributions for nevirapine biotransformation. 2014. Aline Teixeira Marinho; Pereira SA; Pereira, Sofia. https://novaresearch.unl.pt/en/publications/536b5e84-a9bc-4105-ba0f-9ef2105fc200.
DOI: 10.1016/j.toxlet.2014.06.803
Monitoring of the lactonase activity of paraoxonase-1 enzyme in HIV-1-infection. 2014. Pereira SA; E.C. Monteiro; Umbelina de Jesus Albino Caixas; Judit Morello; Aline Teixeira Marinho; Clara Lúcia Gonçalves Dias. https://novaresearch.unl.pt/en/publications/634c6fad-d170-44e8-ab69-74796eb409af.
An animal model to explore efavirenz toxicokinetics and its relation to neurological phenotype. 2014. Pereira SA; E.C. Monteiro. https://novaresearch.unl.pt/en/publications/b5db4ae5-daf5-4c5a-b91c-83007777b01d.
10.1016/j.toxlet.2014.06.813
Thiol status in HIV-infected patients: The effect of nevirapine metabolism. 2014. Inês Varanda de Jesus Faustino; Aline Teixeira Marinho; Clara Lúcia Gonçalves Dias; Umbelina de Jesus Albino Caixas; Pereira SA; E.C. Monteiro. https://novaresearch.unl.pt/en/publications/834768f1-7bc8-4598-87b5-55c902c26d71.
Sex differences in apolipoprotein A1 and nevirapine-induced toxicity. 2014. Pereira SA; E.C. Monteiro; Clara Lúcia Gonçalves Dias; Aline Teixeira Marinho. https://novaresearch.unl.pt/en/publications/1919760a-1152-4c90-ac77-6fd3853bc7b4.
10.7448/IAS.17.4.19575
PON-1 activity as a protective player in nevirapine hepatotoxicity: Data comparison in 2D and 3D cell cultures. 2014. Aline Teixeira Marinho; Clara Lúcia Gonçalves Dias; Pereira SA; E.C. Monteiro. https://novaresearch.unl.pt/en/publications/fa585f80-cf47-47f4-a21b-6ecdebdb704a.
3D hepatocyte cultures: A useful tool in the study of Nevirapine bioactivation and toxicity. 2013. Pereira SA. https://novaresearch.unl.pt/en/publications/3f026dba-afe2-4f84-b45b-b5d77ffd642b.
Mass spectrometric detection of hemoglobin adducts from the anti-HIV drug nevirapine and its metabolite 12-hydroxy-nevirapine in rats. Abstracts of Papers of the American Chemical Society. 2010. E.C. Monteiro; Pereira SA; Marques, Matilde; Godinho, Ana L. A.; Oliveira, Conceicao; Pereira, Sofia A.; Monteiro, Emilia C.; Beland, Frederick A.; Antunes, Alexandra M. M.. https://novaresearch.unl.pt/en/publications/6362d1d6-812d-425d-97d3-c107d81d38ae.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/03/21	Environmental Phenotypes of Kidney related diseases	LS4Future Meeting (Vimeiro, Portugal)
2023/02/03	CORE CONCEPTS IN PHARMACOKINETICS FOR THE INTEGRATED MASTER’S DEGREE IN MEDICINE: A MULTIDISCIPLINARY APPROACH	53rd Meeting of the Portuguese Society of Pharmacology Portuguese Society of Pharmacology (Coimbra, Portugal)
2022/10/11	Activation of the aryl hydrocarbon receptor in the kidney. Implications & Consequences	Translational Nephrology Building the bridge from the bench-to-bedside Portuguese Society of Nephrology (Setúbal)
2022/06	Renal functinal Reserve - how to assess it? II Rim do desportista, Hospital das Forças Armadas, Lisboa	Rim Desportista Hospital das forças Armadas
2022	Pharmacometabolomics of sulfonation: Urinary metabolite profile can predict sulfonation capacity in man.	40ª Reunião de Farmacologia Clínica e 21ª Reunião de Toxicologia./ XXXIX Reunião de Farmacologia Clínica/ XX Reunião de Toxicologia Porto Palácio by The Editory - The Editory Collection Hotels (Porto, Portugal)
2021/02/19	CYSTEINE OXIDATION IS A PUTATIVE AHR ACTIVATOR IN KIDNEY CORTEX (MAL)ADAPTATION TO CHRONIC INTERMITTENT HYPOXIA CONDITIONS	SPF Meeting 2021 Sociedade Portuguesa de Farmacologia; Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2021/02/19	NOVEL MECHANISMS IN ANGIOGENESIS: OXIDATIVE STRESS AS A PROMOTER OF MONOCYTE-TO-ENDOTHELIAL CELL DIFFERENTIATION AND ENDOTHELIAL CELL ACTIVATION	SPF Meeting 2021 Sociedade Portuguesa de Farmacologia; Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2021/02/17	IMPACT OF CHRONIC INTERMITTENT HYPOXIA ON TRYPTOPHAN METABOLISM	SPF Meeting 2021 Sociedade Portuguesa de Farmacologia; Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2021/02/17	PHARMACOLOGICAL PATHWAYS OF THE AHR ANTAGONIST CH-223191 IN KIDNEY IN A MODEL OF ARTERIAL HYPERTENSION ASSOCIATED TO SLEEP APNEA	SPF Meeting 2021 Sociedade Portuguesa de Farmacologia; Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)
2021	Why is the AhR pathway activated at kidney in a model of hypertension associated to obstructive sleep apnea? A focus on tryptophan metabolism	XXXV Congresso Português de Nefrologia Sociedade Portuguesa Nefrologia (Vilamora)
2021	A bet in olive oil: hydroxytyrosol reverts increased blood pressure and cysteine disulfides induced by chronic intermittent hypoxia	ISAC XXI VIRTUAL KICKOFF MEETING Nova Medical School
2021	Hydroxytyrosol is a potential modulator of cysteine redox dynamics and controls increased blood pressure in a model of hypertension associated to obstructive sleep apnea	3rd NMS Symposium on Chronic Diseases and Translational Science CEDOC (Lisbon, Portugal)
2020	Effect of hydroxytyrosol in hypertension induced by chronic intermittent hypoxia	L Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVIII Reunião de Farmacologia Clínica/ XIX Reunião de Toxicologia Faculdade de Farmácia da Universidade de Coimbra (Coimbra, Portugal)
2020	The antihypertensive effect of AHR antagonist is related to circadian variation of blood pressure in Chronic Intermittent Hypoxia condition	L Reunião Anual da Sociedade Portuguesa de Farmacologia/ XXXVIII Reunião de Farmacologia Clínica/ XIX Reunião de Toxicologia (Coimbra, Portugal)
2020	Kidney participation in drug metabolism – opportunities to investigate new players in hypertension	1ª Reunião do ´´Núcleo de Nefrologia de Translação´´ Sociedade Portuguesa Nefrologia (Coimbra, Portugal)
2020	Lesson within Framework of international communication and cooperation between educators/ teachers of clinical pharmacology.	Masaryk University – Fakulty of Medicine (Brno, República Checa)
2019/05/10	Phenotyping the mercapturate pathway to address kidney tubular function.	Casual Friday with Science Centro de estudos de doenças crónicas, Universidade Nova de Lisboa Faculdade de Ciências Médicas (Lisboa, Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2022/09/01 - Atual	Determinants of the activation of the AhR-Cyp1a1 axis in kidney in arterial hypertension associated to obstructive sleep apnea: a matter of agonist and intermittent hypoxia Orientador	Health Sciences (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09/01 - Atual	Precision Urology: Metabolic Phenotype of Patients with Metabolic Syndrome and Recurrent Nephrolithiasis Coorientador	Health Sciences - Medicine (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018/09/01 - Atual	Emerging roles of (per)Sulfidome in Kidney Disease Coorientador	Molecular Biosciences (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2017/09 - 2022/03/24	Hydroxytyrosol and hypertension associated with chronic intermittent hypoxia: impact and contribution of AhR alternative pathway Orientador de Maria João Andrade Correia	Biomedicine (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2022	Variability of sulfotransferase 1A1 (SULT1A1) activity in humans: an approach to improve predictive drug response. Coorientador de Natália Carvalheira de Freitas Marto	Medicine (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - 2021/01	Targeting AhR metabolic circuitry for better management of arterial hypertension in obstructive sleep apneia. Orientador de António Pimpão	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2021	Monocytes as neoangiogenesis promoters and anti-cancer targets. Coorientador de Filipa Lopes Coelho	Mechanisms of disease and Regenerative Medicine (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2020	Systemic Lupus Erythematosus: development of methodologies based on the technique of mass spectrometry for the diagnosis / prognosis of the disease. Coorientador de Catarina Sofia Romão Charneira	Chemistry (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015 - 2020	Aryl hydrocarbon receptor (AhR): a therapeutic target for systemic hypertension associated with chronic intermittent hypoxia. Coorientador de Nuno Filipe Ramos Coelho	Mecanismos de Doença e Medicina Regenerativa (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2019	Investigating the role of the mercapturate pathway in kidney function for the identification of an early indicator tubular dysfunction. Orientador de Clara Lúcia Gonçalves Dias	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2019	Cysteine, a facilitator of hypoxia adaptation and a promoter of drug resistance- a new route to better diagnose and treat ovarian cancer patients. Coorientador de Ana Sofia de Almeida da Costa Nunes	Mecanismos de Doença e Medicina Regenerativa (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2018	Teaching an old drug new tricks: reprofiling of nevirapine as an HDL modulator. Individual PhD Fellowship SFRH/BD/92191/2013 Orientador de Aline Teixeira Marinho	Mechanisms of Disease and Regenerative Medicine (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/10 - 2017	Changes in N-acetyltransferase 8 in kidney tubular cell: Injury, recovery and mesenchymal stem/stromal cell treatment. Orientador de Patrícia Canotilho dos Santos Grácio	Ciências de Engenharia - Engenharia Biomédica (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 - 2017	The anti-HIV drug Efavirenz: a challenge on molecular mechanisms of drug associated neurocognitive disorders. Individual PhD Fellowship SFRH/BD/86791/2012. Orientador de Nádia Filipa Marques Grilo	Ciências da Vida (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2016	S-thiolated protein profile to assess the redox modulation effects of antiretroviral drugs. Orientador de Maria João Correia	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015	Molecular targeting of proteins by homocysteine in clinical and familial hypercholesterolemia. Orientador de Ana Rita Lemos	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014 - 2015	Usefulness of zebrafish model to assessglomerular and tubular alterationsinduced by tenofovir. Coorientador de Rita Gorgulho	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2013 - 2015	Zebrafish as a model for toxicological studies: is there a role for Paraoxonase? Orientador de Lara Andreia Pires Afonso	Biologia Humana e Ambiente (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2012 - 2013	Nevirapine biotransformation in a type II diabetes model. Orientador de Patricia Marques Rodrigues	Biotecnologia (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2013	HDL in HIV-1 infection: a quality perspective through paraoxonase-1 activities. Orientador de Clara Dias	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012 - 2013	New insights on nevirapine use: A mechanistic perspective of its toxic events. Orientador de Aline Teixeira Marinho	Ciências Biomédicas (Mestrado) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2011 - 2012	Protein adducts from the anti-HIV drug abacavir – possible biomarkers of drug toxicity. Orientador de Nádia Filipa Marques Grilo	Genética Molecular e Biomedicina (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2024/02/07 - 2024/02/09	Organisation of the 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology (2024/02/07 - 2024/02/09) Encontro (Membro da Comissão Organizadora)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2015	Organization of the Meeting of the Portguese Society of Pharmacology 2015 (2015 - 2015) Encontro (Membro da Comissão Organizadora)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2021 - Atual	Chair of Cardiovascular & Renal Pharmacology session Congresso	3rd NMS Symposium on Chronic Diseases and Translational Science Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2014 - Atual	Pariticipation in the OPEN DAYS of the institute (outreach activities). Outro	CEDOC Open Days Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021/04/11 - 2021/04/14	ESH-ISH Joint Meeting - Hypertension meeting participation Encontro	ESH-ISH Joint Meeting
2012 - 2020	Chariwomen at several (pharmacology, cancer, toxicology) sessions at SPF meetings Encontro	SPF meeting Sociedade Portuguesa de Farmacologia, Portugal
2019/09/04 - 2019/09/06	Co-author of one of the works presented: Effect of cysteinyl- S-conjugates on the function and structure of human enzymes involved in hydrogen sulfide metabolism Encontro	NOVABiophysica Universidade Nova de Lisboa, Portugal

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2022/07/20	In Vivo Phenotyping of Sult1a enzymes in man: implications for precision medicine Orientador	Natália Marto (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/02/23	"Nose-to-brain Delivery of Lacosamide, Levetiracetam and Zonisamide and the Impact of BCRP Efflux: an In Vitro/In Vivo Approach". Arguente	Joana Carrapiço Gonçalves (Doutoramento) Universidade de Coimbra, Portugal
2021/12/20	"Targeting the carotid bodies to treat obesity" Arguente	Bernardete Sofia Freitas de Melo. (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/01/26	"Development of point-of-care tests using enzyme (NiR & PON) based electrochemical biosensors." Vogal	Tiago Carvalho Monteiro (Mestrado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2020/12/09	The neurotoxicity of doxorubicin and mitoxantrone: chemobrain studies using infant, adult, and old mice. Arguente	Ana Rita Constantino Dias de Carvalho (Mestrado) Universidade do Porto Faculdade de Farmácia, Portugal
2020/01	Evaluation to recognition of foreign qualifications at the level of Doctorate of the thesis “Regulation of Clostridium acetobutylicum glutamine synthetase glnA gene”.	Ivo Pedro Fierro-Monti (Doutoramento)
2020	Metabolomics of Menopause in HIV-infected women Arguente	Cláudia Nunes (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2019/11/28	Characterization and modulation of the Renin-Angiotensin System in Diabetic Retinopathy. Arguente	Brigite Ladeira Cabrita (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/02/19	Bioanalytical tools for unraveling part of the puzzle of the biochemical phenomena in epilepsy: neuromediators and antiepileptic drugs Arguente	Beatriz Marques da Fonseca (Doutoramento) Universidade da Beira Interior, Portugal
2017	Estratégias in vitro e in vivo para o estudo da bioativação do fármaco anti-HIV Etravirina Arguente	Ana Godinho (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017	Development of three-dimensional umbilical cord-derived cell culture for differentiation into hepatocyte-like cells: a potential breakthrough in toxicological drug screening Arguente	Madalena Cipriano (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015	Bioactivação do fármaco anti-VIH Nevirapina: quantificação por espectrometria de massa de alta resolução de adutos covalentes formados com a hemoglobina. Arguente	Catarina Oliveira (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014	Evaluation of the therapeutic potential of the umbilical cord tissue-derived mesenchymal stromal cells (UCX®) 3D cultures for tissue regeneration Arguente	Sérgio Camões (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2012	Metabolitos fenólicos do fármaco anti-HIV Nevirapina: Mecanismos de bioactivação em culturas 3D de hepatócitos de rato Arguente	Pedro Pinheiro (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2015 - Atual	Meeting of the Portuguese Society of Pharmacology	Faculdade de Ciências Médicas de Lisboa
2021/06/16 - 2021/06/18	Third CEDOC Symposium on Chronic Diseases and Translational Science	CEDOC-NMS
2021/02/17 - 2021/02/17	3rd NMS Symposium on Chronic Diseases and Translational Science	CEDOC\|NMS
2017 - 2017	VI in4Med	Faculdade de Medicina, Universidade de Coimbra

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2021/10/31 - Atual	MPDI - Special Issue "Small Molecules: A Field of Opportunities for Differential Diagnosis and Precision Medicine" (1420-3049)
2021/09/30 - Atual	Frontiers in Pharmacology - Non-Cytochrome P450 Enzymes and Extra-Hepatic Drug Metabolism: Challenges and Opportunities (1663-9812 )	Frontiers
2020/02/20 - 2020/02/20	Frontiers - Metabolomics in Toxicology: From Mechanistic Elucidation to Preventive and Therapeutic Strategies	Frontiers
2019/03/31 - 2019/03/31	High-throughput - Special Issue "Adductomics: Elucidating the Environmental Causes of Disease" (2571-5135)	MDPI

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2022 - Atual	2022 PhD grant evaluation in the area of Biomedicine Avaliador	Fundação para a Ciência e a Tecnologia, Portugal
2013 - Atual	Prize Astrazeneca Innovate Foundation at iMed Conference. Avaliador	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/09/30 - 2021/10/02	Juri - Best poster - 12 Topics in Rheumatology meeting	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 - 2021	PhD grant evaluation in the area of Clinical Medicine and Health Sciences. Avaliador	Fundação para a Ciência e a Tecnologia, Portugal
2020/03 - 2020/04	´´RESEARCH 4 COVID-19``: Evaluation of R&D projects and initiatives that respond to the needs of the National Health Service (SNS) in response to this and future pandemics in a very short time horizon. Avaliador	Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2020/03/06 - 2020/03/07	Juri - Best poster - 12 Topics in Rheumatology meeting	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - 2015	Pfizer Prizes for biomedical research projects in Portugal Avaliador		Universidade Nova de Lisboa Faculdade de Ciências Médicas
2012 - 2012	Evaluation Panel of PhD programme in Life Sciences Avaliador	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2020 - Atual	Teaching in Curricular Unit of Integrative Biomedicine of Biomedicine PhD 1st Year	BIOMEDICINE PhD	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020 - Atual	Clinical pharmacology within the framework of international communication and cooperation between educators/ teachers of clinical pharmacology.	Medicine (Bachelor (1.º ciclo de estudos))	Masarykova univerzita, República Checa
2018 - Atual	Master NOVA Biomedical Research. Curriular Unit "Aging and chronic diseases: from molecular mechanisms to therapies"	NOVA Biomedical Research (Mestrado)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013 - Atual	Integrated Master Degree in Medicine. Nuclear curricular unit "Infection: aetiology, pathogenesis and therapeutics; practical classes, elaboration and correction of tests".	Medicina (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - Atual	Integrated Master Degree in Medicine. Nuclear curricular unit "General Pharmacology; theoretical and practical classes, elaboration and correction of tests".	Medicina (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - Atual	Integrated Master Degree in Medicine. Nuclear curricular unit of Phatophysiology and Therapeutic Targets; theoretical and practical classes, elaboration and correction of tests.	Medicina (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2012 - Atual	PhD Program "Life Sciences". Lecture Translational Research.	Ciências da Vida (Doutoramento)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/06/05 - 2020/06/06	Seminar - NOVA Biomedical Research Master	Seminars (Mestrado)
2016 - 2017	Integrated Master Degree in Medicine. Optional curricular unit "Methods for the quantification of endogenous metabolites in biological fluids"	Medicina (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2015 - 2017	Master in Clinical Trials and Medical Affairs	Master em Monitorização de Ensaios Clínicos e Medical Affairs (Mestrado)	Centro de Estudos Superiores da Indústria Farmacêutica, Portugal
2013 - 2015	Integrated Master Degree in Medicine. Optional curricular unit "Translational Medicine in Chronic Diseases and Aging". Topic: "Pharmacogenomics, ratios of metabolites and metabolic phenotypes".	Medicina (Mestrado integrado)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2013 - 2015	PhD Program "Mechanisms of Disease and Regenerative Medicine". Curricular unit "Degenerative and Chronic Diseases" . Topic: "Drug toxicity as mechanism of disease. The roleof antiretroviral drug toxicity: from cell to clinic".	Mecanismos de Doença e Medicina Regenerativa (Doutoramento)	Universidade do Algarve, Portugal Universidade Nova de Lisboa, Portugal
2012 - 2013	Integrated Master Degree in Medicine. Topics: "Pharmacokinetics", Drug toxicity", "Drugs inhibiting Cellular Proliferation", "Variability in Drug Response"	Medicina (Mestrado integrado)	Universidade do Algarve, Portugal
2006 - 2007	Postgraduate Course in Monitoring of Clinical Trials. Lecture in Pharmacokinetics		Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2019/11/15	Environmental changes: Pollution as an atherogenic factor	Journal NewsFarma CONGRESSO (XXVII Congresso Português de Aterosclerose)

Membro de associação

	Nome da associação	Tipo de participação
2022 - Atual	COST Action CA20121 Bench to Bedside transition for Pharmacological regulation of NRF2 in non communicable diseases	Member
2016 - Atual	Portuguese Society of Nephrology
2007 - Atual	Portuguese Society of Pharmacology
2020 - 2024	CA19115 - Network for blood pressure research in children and adolescents. (https://www.cost.eu/actions/CA19115/#tabs\|Name:overview)	Member
2020 - 2024	CA19127 - Cognitive decline in Nephro-Neurology: European Cooperative Target. (https://www.cost.eu/actions/CA19127/#tabs\|Name:overview)	Member
2016 - 2020	Diagnosis, Monitoring and Prevention of exposure related non-communicable diseases, DiMoPEx (CA 15129)	Member
2005 - 2011	SIDAnet Portuguese Association	Secretary

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2023/02 - Atual	NMS Research area Cardiovasular, renal and metabolic diseases Coordenador	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/04/24 - Atual	Coordinator of the Pedagogical Committee of the 2nd year of the Integrated Master in Medicine. Coordenador	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021 - 2021	Selection of abstracts at iMed Conference® 13.0 Consultor	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2018 - 2019	Development of guidelines and evaluation structure for the course: Thesis within the scope of the PhD in Biomedicine PhD Presidente / Vice-presidente	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2019	Member of the Scientific Committee of the Faculdade de Ciências Médicas de Lisboa Membro	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2022 - 2023	Jury for the application procedure for the PhD in Biomedicine	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2020/07/02	Evaluation of the Student Rita Coelho at PROJECT IN CELL AND MOLECULAR BIOLOGY discipline	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2020/07/02	Evaluation of the student Joana Reis at PROJECT IN CELL AND MOLECULAR BIOLOGY discipline	Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/07/09 - 2020	Analysis, evaluation and selection of doctoral applications in biomedicine -5th edition (Academic year of 2019/2020).	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/07 - 2019/07	Jury on evaluation of master thesis plan of 2 students on NBR master course.	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/05/24 - 2019/05/24	International selection procedure for hiring a Doctorate under Articles 18 and 20 of Decree-Law No. 57/2016, of 29 August, amended by Law No. 57/2017. (Aviso n.º 9148/2019)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019 - 2019	Evaluation of doctoral intention in medicine of the project´´The effect of preoperative dexamethasone on postimplantation syndrome after endovascular aneurysm repair - protocol for a randomized controlled trial´´ from the student Ana Rita Pinho Soares Ferreira.	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2016	Jury of the public tender to contrat a Superior Technician at Faculdade de Ciências Médicas de Lisboa.	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014 - 2014	Evaluation of the experimental period of the Superior Technician Inês Varanda de Jesus Faustino	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2011 - 2011	Jury of the public tender to contrat a Superior Technician at Faculdade de Ciências Médicas de Lisboa.	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Tutoria

	Tópico	Nome do aluno
2020 - Atual	Portugal Clinical Scholars Research Training (PTCSRT)	Clara Matos

Distinções

Prémio

2022	Best work submitted in Basic Nephrology
2022	DeCastro-Heymans-Neil Award" Best Oral Presentation 3rd Prize (for best oral presentation) Renal AHR-CYP1A1 activation by chronic intermittent hypoxia is related to arterial hypertension and depends on its chronicity.
2022	Bolsa de Investigação em Urologia 2022 Sociedade Portuguesa de Neurologia, Portugal
2021	Best work submitted in Basic Nephrology Sociedade Portuguesa de Nefrologia, Portugal
2017	Best work submitted in Basic Nephrology Sociedade Portuguesa de Nefrologia, Portugal
2017	Travel Grant. Thiol oxidation in toxicity and signaling workshop organized by EMBO
2015	Gilead GÉNESE Portugal Program. PGG/032/2015 – Renal tubular lesion in HIV-infected patients: progression and interaction. (PGG/032/2015). Gilead Sciences Lda, Portugal
2013	Project: HIV-Nefromics - Novel markers of antiretroviral induced nephrotoxicity in HIV infected patients Sociedade Portuguesa de Nefrologia, Portugal
2013	Best Oral Presentation on the "2nd International Conference on Occupational & Environmental Toxicology", Journals of Toxicology and Environmental Health and Taylor & Francis Group
2013	Honoroble mention for best poster on the "5.0 iMed Conference"
2011	ERASMUS Movility Grant for training at the Pharmacy & Pharmacology Department of Slotervaart Hospital, Amsterdam, Holland
2009	Research Fellowship Luso-American Development Foundation (FLAD)
2004	Best oral presentation - clinical case. VI Jornadas de Infecção pelo VIH Sociedade Portuguesa de Medicina Interna, Portugal
2002	BIC fellowship Fundação para a Ciência e a Tecnologia, Portugal
2001	Program of stays in superior education (Prodept). PRODEP III MEDIDA 3 ACÇÃO, public call n1/3.2/PRODEP/2002
2001	PRODEPT fellowship

Outra distinção

2018	Prémio melhor comunicação em painel Clara G. Dias, Nuno R. Coelho, Maria J. Correia, Filipa Lopes-Coelho, Maria J. Meneses, Inês Sousa-Lima, Jacinta Serpa, Maria P. Macedo, Karina Soto, Emília C. Monteiro, Sofia A. Pereira. Renal cysteine-disulfide stress