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My group specializes in developing sophisticated in vitro human models, which better mimic the in vivo micro-environment and functionality, using Organs-on-a-Chip (OoC). This includes developing and integrating sophisticated sensors in the OoC platform to allow in situ measurements of the cellular electrophysiology, metabolism, secretome and other vital parameters. These expertises are crucial to this project, as we previously demonstrated that such OoC models of the brain can lead to the identification of new physiology. Moreover, together with the Ingber lab (Harvard), in which I gained skills as a post-doctoral fellow, we were able to create a model that can extrapolate and correlate the OoC results to a human – clinical data, while developing a platform for linking 7 human OoC, to allow high throughput drug screening. This huge leap saves labs, both in academia and pharma, time and money, as it presents human relevant models which can be translated to clinical data. I am currently the PI of 5 grants, including and ERC Starting Grant (Using Brain-on-a-Chip (BoaC) to study neurodegenerative disease). I have been an invited speaker for a number of national (> 6) and international (> 4) conferences. The complete list of publications can be found at https://scholar.google.com/citations?user=-6wwx7gAAAAJ&hl=en.
Identificação

Identificação pessoal

Nome completo
Ben Maoz

Nomes de citação

  • Maoz, Ben
  • Maoz BM
  • Maoz Ben Meir
  • Maoz, Ben M

Identificadores de autor

Ciência ID
6E15-90EF-96D4
ORCID iD
0000-0002-3823-7682

Endereços de correio eletrónico

  • bmaoz@tauex.tau.ac.il (Profissional)

Telefones

Telemóvel
  • (+972) 0543975882 (Profissional)

Moradas

  • Tel Aviv University, 30 Haim Levanon, 69978, Tel Aviv, Tel Aviv, Israel (Profissional)

Websites

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Engenharia Médica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Hebraico (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador proficiente (C1) Utilizador independente (B1) Utilizador elementar (A2) Utilizador proficiente (C1) Utilizador independente (B1)
Formação
Grau Classificação
2014
Concluído
mini-MBA (Diplôme d´études supérieures)
Harvard Business School, Estados Unidos
2010/06/01 - 2013/06/01
Concluído
Chemistry (Doctor of Philosophy)
Especialização em Chemistry
Tel Aviv University, Israel
"Preparation and Characterization of Chiral Metal Nanostructures and Their Interaction with Chiral Molecules" (TESE/DISSERTAÇÃO)
2008/06/01 - 2010/06/01
Concluído
Chemistry (Master)
Especialização em Chemistry
Tel Aviv University, Israel
"Synthesis and Properties of Highly Defective MgO Nanosheets" (TESE/DISSERTAÇÃO)
2006/10/01 - 2008/06/01
Concluído
Chemistry (Bachelor)
Especialização em Chemistry
Tel Aviv University, Israel
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2018 - Atual Investigador principal (carreira) (Investigação) Biomedical Engineering – Faculty of Engineering, Tel Aviv University, Israel, Israel
2013 - 2018 Pós-doutorado (Investigação) Harvard University John A Paulson School of Engineering and Applied Sciences, Estados Unidos
2015/07 - 2015/08 Investigador visitante (Investigação) Sogang-Harvard Disease Biophysics Research Center, Sogang University, Seoul, South Korea, Coreia do Sul
2011/08 - 2011/11 Investigador visitante (Investigação) Columbia University Department of Chemistry, Estados Unidos
2008 - 2010 Assistente de Investigação (carreira) (Investigação) Weizmann Institute of Science, Israel
2007 - 2008 Estagiário de Investigação (Investigação) Tel-Aviv University Department of Biochemistry and Molecular Biology, Israel
2006 - 2008 Estagiário de Investigação (Investigação) Tel Aviv University School of Chemistry, Israel
2007/07 - 2007/08 Estagiário de Investigação (Investigação) Weizmann Institute of Science Feinberg Graduate School, Israel

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2018 - Atual Professor Associado (Docente Universitário) Biomedical Engineering – Faculty of Engineering, Tel Aviv University, Israel, Israel

Outros

Categoria Profissional
Instituição de acolhimento
Empregador
2020 - Atual Guest Editor for Brain-on-a-Chip: Micromachines Multidisciplinary Digital Publishing Institute AG, Suiça
Projetos

Bolsa

Designação Financiadores
2020/09 - 2025/08 A new perspective on the metabolic pathway to neuronal dysfunction: Using organs on a chip to elucidate the role of the brain microvasculature European Research Council
2019/01 - 2022/12 Understanding Neuronally-Induced Skin Hypermetabolism Activated by Burn Trauma: Using an Organ-on-a-Chip Platform Mimicking Skin-Cell–Neuron Interactions
52648
Israel Science Foundation
2020 - 2022 ERC: A new perspective on the metabolic pathway to neuronal dysfunction: Using organs on a chip to elucidate the role of the brain microvasculature
LS9_SweetBrain_001
Investigador responsável
2019 - 2021 Israel Science Foundation (ISF): Understanding Neuronal induced Skin Hypermetabolism Activated by Burn Trauma using Organs-on-a-Chip
2019-0001
Investigador responsável
2019 - 2020 MAFAT: Bio-senso-robot: Hybrid Insect-Robotic Sensory Systems
2019-0001
Investigador responsável
2019 - 2020 TEVA Initiative projects: Creating a High throughput Human Relevant Physiological Assessment in Fluidically Linked Organ-on-a-Chip Platform for Drug Screening
Teva_001
Investigador responsável
2018 - 2020 Azrieli Foundation for Excellence Science: Identifying Communication Between the Brain Vasculature and Neurons as a Drug Target for Traumatic Brain Injury: A Metabolically Coupled Decomposition of the Neurovascular Unit Using Organs-on-a-Chip
2018-001
Investigador responsável
2018 - 2019 Brain Boost: Automated Organs-on-a-Chip platform for high throughput drug assessment
0001
Investigador responsável
2018 - 2019 Elizabeth and Nicholas Slezak Super-Center: Mimicking Cardiomyocyte Functionality In Vitro Using Magnetic Gels
2018-001
Investigador responsável
Produções

Publicações

Artigo em revista
  1. Schlotterose, L.; Beldjilali-Labro, M.; Hagel, M.; Yadid, M.; Flaxer, C.; Flaxer, E.; Barnea, A.R.; et al. "Inducing Mechanical Stimuli to Tissues Grown on a Magnetic Gel Allows Deconvoluting the Forces Leading to Traumatic Brain Injury". Neurotrauma Reports 4 1 (2023): 560-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-85171649229&partnerID=MN8TOARS.
    10.1089/neur.2023.0026
  2. Yogev, D.; Goldberg, T.; Arami, A.; Tejman-Yarden, S.; Winkler, T.E.; Maoz, B.M.. "Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges". APL Bioengineering 7 3 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85173051150&partnerID=MN8TOARS.
    10.1063/5.0152290
  3. Sade, O.; Boneberg, R.; Weiss, Y.; Beldjilali-Labro, M.; Leichtmann-Bardoogo, Y.; Talpir, I.; Gottfried, I.; et al. "Super-Resolution-Chip: an in-vitro platform that enables super-resolution microscopy of co-cultures and 3D systems". Biomedical Optics Express 14 10 (2023): 5223-5237. http://www.scopus.com/inward/record.url?eid=2-s2.0-85174360814&partnerID=MN8TOARS.
    10.1364/BOE.498038
  4. Melnikov, N.; Kobel, P.; Detinis, T.; Segni, A.D.; Leichtmann-Bardoogo, Y.; Haik, J.; Maoz, B.M.. "An automated high-throughput platform for experimental study of burn injuries - in vitro and ex vivo". Burns 49 5 (2023): 1170-1180. http://www.scopus.com/inward/record.url?eid=2-s2.0-85139043034&partnerID=MN8TOARS.
    10.1016/j.burns.2022.08.019
  5. Yadid, M.; Hagel, M.; Labro, M.B.; Le Roi, B.; Flaxer, C.; Flaxer, E.; Barnea, A.R.; et al. "A Platform for Assessing Cellular Contractile Function Based on Magnetic Manipulation of Magnetoresponsive Hydrogel Films". Advanced Science 10 27 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85165470619&partnerID=MN8TOARS.
    10.1002/advs.202207498
  6. Rauti, R.; Navok, S.; Biran, D.; Tadmor, K.; Leichtmann-Bardoogo, Y.; Ron, E.Z.; Maoz, B.M.. "Insight on Bacterial Newborn Meningitis Using a Neurovascular-Unit-on-a-Chip". Microbiology Spectrum 11 3 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85163913793&partnerID=MN8TOARS.
    10.1128/spectrum.01233-23
  7. Schlotterose, L.; Beldjilali-Labro, M.; Schneider, G.; Vardi, O.; Hattermann, K.; Even, U.; Shohami, E.; et al. "Traumatic Brain Injury in a Well: A Modular Three-Dimensional Printed Tool for Inducing Traumatic Brain Injury in vitro". Neurotrauma Reports 4 1 (2023): 255-266. http://www.scopus.com/inward/record.url?eid=2-s2.0-85167725139&partnerID=MN8TOARS.
    10.1089/neur.2022.0072
  8. Sela, M.; Poley, M.; Mora-Raimundo, P.; Kagan, S.; Avital, A.; Kaduri, M.; Chen, G.; et al. "Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease". Advanced Materials (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85174902644&partnerID=MN8TOARS.
    10.1002/adma.202304654
  9. Guillem Vargas-Nadal; Mariana Köber; Audrey Nsamela; Francesca Terenziani; Cristina Sissa; SILVIA PESCINA; Fabio Sonvico; et al. "Fluorescent Multifunctional Organic Nanoparticles for Drug Delivery and Bioimaging: A Tutorial Review". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/11/2498.
    10.3390/pharmaceutics14112498
  10. "Effect of SARS-CoV-2 proteins on vascular permeability". eLife 10 (2021): http://dx.doi.org/10.7554/elife.69314.
    10.7554/elife.69314
  11. Fishel, Idan; Amit, Yoni; Shvil, Neta; Sheinin, Anton; Ayali, Amir; Yovel, Yossi; Maoz, Ben M.. "Ear-Bot: Locust Ear-on-a-Chip Bio-Hybrid Platform". Sensors 21 1 (2021): 228. http://dx.doi.org/10.3390/s21010228.
    10.3390/s21010228
  12. Rauti, Rossana; Shahoha M; Leichtmann-Bardoogo Y; Nasser R; Tamir R; Miller V; Babich T; et al. "Effect of SARS-CoV-2 proteins on vascular permeability". bioRxiv (2021):
    Em revisão
  13. "Spatial Trans-Epithelial Electrical Resistance (S-TEER) Integrated in Organs-on-Chips". Lab on a Chip (2021): http://dx.doi.org/10.1039/d1lc00789k.
    10.1039/d1lc00789k
  14. Nikolakopoulou, Polyxeni; Rauti, Rossana; Voulgaris, Dimitrios; Shlomy, Iftach; Maoz, Ben M; Herland, Anna. "Recent progress in translational engineered in vitro models of the central nervous system". Brain 143 11 (2020): 3181-3213. http://dx.doi.org/10.1093/brain/awaa268.
    10.1093/brain/awaa268
  15. Afflerbach, Ann-Kristin; Kiri, Mark D.; Detinis, Tahir; Maoz, Ben M.. "Mesenchymal Stem Cells as a Promising Cell Source for Integration in Novel In Vitro Models". Biomolecules 10 9 (2020): 1306. http://dx.doi.org/10.3390/biom10091306.
    10.3390/biom10091306
  16. Herland, Anna; Maoz, Ben M.; FitzGerald, Edward A.; Grevesse, Thomas; Vidoudez, Charles; Sheehy, Sean P.; Budnik, Nikita; et al. "Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine". Advanced Biosystems 4 9 (2020): 1900230. http://dx.doi.org/10.1002/adbi.201900230.
    10.1002/adbi.201900230
  17. Herland, Anna; Maoz, Ben M; Das, Debarun; Somayaji, Mahadevabharath R.; Prantil-Baun, Rachelle; Novak, Richard; Cronce, Michael; et al. "Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips". Nature Biomedical Engineering (2020): http://dx.doi.org/10.1038/s41551-019-0498-9.
    10.1038/s41551-019-0498-9
  18. Novak R; Ingram M; Clauson S; Das D.; Maoz, Ben; Jeanty SSF; Somayaji MR; et al. "A robotic platform for fluidically-linked human body-on-chips experimentation". Nature Biomedical Engineering (2020): https://doi.org/10.1101/569541.
  19. Rauti, Rossana; Renous, Noa; Maoz, Ben M.. "Mimicking the Brain Extracellular Matrix in Vitro : A Review of Current Methodologies and Challenges". Israel Journal of Chemistry (2019): http://dx.doi.org/10.1002/ijch.201900052.
    10.1002/ijch.201900052
  20. Maoz, Ben M; Herland, Anna; FitzGerald, Edward A; Grevesse, Thomas; Vidoudez, Charles; Pacheco, Alan R; Sheehy, Sean P; et al. "A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells". Nature Biotechnology 36 9 (2018): 865-874. http://dx.doi.org/10.1038/nbt.4226.
    10.1038/nbt.4226
  21. Dauth, Stephanie; Maoz, Ben M.; Sheehy, Sean P.; Hemphill, Matthew A.; Murty, Tara; Macedonia, Mary Kate; Greer, Angie M.; Budnik, Bogdan; Parker, Kevin Kit. "Neurons derived from different brain regions are inherently different in vitro: a novel multiregional brain-on-a-chip". Journal of Neurophysiology 117 3 (2017): 1320-1341. http://dx.doi.org/10.1152/jn.00575.2016.
    10.1152/jn.00575.2016
  22. Maoz, Ben M.; Herland, Anna; Henry, Olivier Y. F.; Leineweber, William D.; Yadid, Moran; Doyle, John; Mannix, Robert; et al. "Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities". Lab on a Chip 17 13 (2017): 2294-2302. http://dx.doi.org/10.1039/c7lc00412e.
    10.1039/c7lc00412e
  23. Park, S.-J.; Gazzola, M.; Park, K. S.; Park, S.; Di Santo, V.; Blevins, E. L.; Lind, J. U.; et al. "Phototactic guidance of a tissue-engineered soft-robotic ray". Science 353 6295 (2016): 158-162. http://dx.doi.org/10.1126/science.aaf4292.
    10.1126/science.aaf4292
  24. Dauth, Stephanie; Grevesse, Thomas; Pantazopoulos, Harry; Campbell, Patrick H.; Maoz, Ben M.; Berretta, Sabina; Parker, Kevin Kit. "Extracellular matrix protein expression is brain region dependent". Journal of Comparative Neurology 524 7 (2016): 1309-1336. http://dx.doi.org/10.1002/cne.23965.
    10.1002/cne.23965
  25. Arteaga, Oriol; Sancho-Parramon, Jordi; Nichols, Shane; Maoz, Ben M.; Canillas, Adolf; Bosch, Salvador; Markovich, Gil; Kahr, Bart. "Relation between 2D/3D chirality and the appearance of chiroptical effects in real nanostructures". Optics Express 24 3 (2016): 2242. http://dx.doi.org/10.1364/oe.24.002242.
    10.1364/oe.24.002242
  26. Arteaga, Oriol; Maoz, Ben M.; Nichols, Shane; Markovich, Gil; Kahr, Bart. "Complete polarimetry on the asymmetric transmission through subwavelength hole arrays". Optics Express 22 11 (2014): 13719. http://dx.doi.org/10.1364/oe.22.013719.
    10.1364/oe.22.013719
  27. Nichols S; Arteaga O; Maoz, Ben; Markovich G; Kahr B. "Polarimetric analysis of the extraordinary optical transmission through subwavelength hole arrays". Proceedings Plasmonics: Metallic Nanostructures and Their Optical Properties XII; 91631W 9163 (2014): https://doi.org/10.1117/12.2063235.
  28. Tesler, Alexander B.; Maoz, Ben M.; Feldman, Yishay; Vaskevich, Alexander; Rubinstein, Israel. "Solid-State Thermal Dewetting of Just-Percolated Gold Films Evaporated on Glass: Development of the Morphology and Optical Properties". The Journal of Physical Chemistry C 117 21 (2013): 11337-11346. http://dx.doi.org/10.1021/jp400895z.
    10.1021/jp400895z
  29. Maoz, Ben M.; Chaikin, Yulia; Tesler, Alexander B.; Bar Elli, Omri; Fan, Zhiyuan; Govorov, Alexander O.; Markovich, Gil. "Amplification of Chiroptical Activity of Chiral Biomolecules by Surface Plasmons". Nano Letters 13 3 (2013): 1203-1209. http://dx.doi.org/10.1021/nl304638a.
    10.1021/nl304638a
  30. Shevach, Michal; Maoz, Ben M.; Feiner, Ron; Shapira, Assaf; Dvir, Tal. "Nanoengineering gold particle composite fibers for cardiac tissue engineering". Journal of Materials Chemistry B 1 39 (2013): 5210. http://dx.doi.org/10.1039/c3tb20584c.
    10.1039/c3tb20584c
  31. Ben-Moshe, Assaf; Maoz, Ben M.; Govorov, Alexander O.; Markovich, Gil. "Chirality and chiroptical effects in inorganic nanocrystal systems with plasmon and exciton resonances". Chemical Society Reviews 42 16 (2013): 7028. http://dx.doi.org/10.1039/c3cs60139k.
    10.1039/c3cs60139k
  32. Maoz, Ben M.; van der Weegen, Rob; Fan, Zhiyuan; Govorov, Alexander O.; Ellestad, George; Berova, Nina; Meijer, E. W.; Markovich, Gil. "Plasmonic Chiroptical Response of Silver Nanoparticles Interacting with Chiral Supramolecular Assemblies". Journal of the American Chemical Society 134 42 (2012): 17807-17813. http://dx.doi.org/10.1021/ja309016k.
    10.1021/ja309016k
  33. Maoz, Ben M.; Ben Moshe, Assaf; Vestler, Daniel; Bar-Elli, Omri; Markovich, Gil. "Chiroptical Effects in Planar Achiral Plasmonic Oriented Nanohole Arrays". Nano Letters 12 5 (2012): 2357-2361. http://dx.doi.org/10.1021/nl300316f.
    10.1021/nl300316f
  34. Maoz, Ben M.; Tirosh, Einat; Bar Sadan, Maya; Markovich, Gil. "Defect-induced magnetism in chemically synthesized nanoscale sheets of MgO". Physical Review B 83 16 (2011): http://dx.doi.org/10.1103/physrevb.83.161201.
    10.1103/physrevb.83.161201
  35. Karakouz, Tanya; Maoz, Ben M.; Lando, Gilad; Vaskevich, Alexander; Rubinstein, Israel. "Stabilization of Gold Nanoparticle Films on Glass by Thermal Embedding". ACS Applied Materials & Interfaces 3 4 (2011): 978-987. http://dx.doi.org/10.1021/am100878r.
    10.1021/am100878r
  36. Maoz, Ben M.; Tirosh, Einat; Sadan, Maya Bar; Popov, Inna; Rosenberg, Yuri; Markovich, Gil. "Highly defective MgO nanosheets from colloidal self-assembly". Journal of Materials Chemistry 21 26 (2011): 9532. http://dx.doi.org/10.1039/c1jm10181a.
    10.1039/c1jm10181a
  37. Greenstein, Miryam; Ben Ishay, Rivka; Maoz, Ben M.; Leader, Haim; Vaskevich, Alexander; Rubinstein, Israel. "Rapid Formation of Coordination Multilayers Using Accelerated Self-Assembly Procedure (ASAP)". Langmuir 26 10 (2010): 7277-7284. http://dx.doi.org/10.1021/la904421n.
    10.1021/la904421n
Livro
  1. Maoz, Ben. Chemistry Handbook. Tel-Aviv, Israel. 2008.
Poster em conferência
  1. Maoz, Ben; Stephanie Dauth; Sean P. Sheehy; Matthew A. Hemphill; Tara Murty; Mary Kate Macedonia; Angie M. Greer; Bogdan Budnik; Kevin Kit Parker. "Neurons derived from different brain regions are inherently different in vitro: A novel multiregional brain-on-a-chip for disease study". Trabalho apresentado em MNIH Workshop: Using stem cellbased assays for biological & drug discovery; Sanford Consortium, La Jolla, CA, USA, 2016.
  2. Lisa Scudder; Johan Lind; Sung Jin Park; Peyton Nesmith; Adrian Buganza; Moran Yadid; Ville Kujala; et al. "Human Cardiopulmonary System on a Chip: A Platform for Stem Cell Therapy and Modelling Disease". Trabalho apresentado em Microphysiological Systems Review Meeting; DARPA Conference Center, Arlington, Virginia, USA, 2016.
  3. Andrzej J. Przekwas; Mahadevabharath R. Somayaji; Grace Chen; XG Tan; Maoz, Ben; Kevin Kit Parker; Raj K. Gupta. "Mechanobiology of Diffuse Axonal Injury: Mechanisms and Opportunities for Early Neuroprotection". Trabalho apresentado em Military Health System Research Symposium (MHSRS), Orlando, Florida, USA, 2016.
  4. Maoz, Ben; Thomas Grevesse; Stephanie Dauth; Angie Greer; Kevin Kit Parker. "Brain on a Chip as a Tool For Neuronal Network Functionality Assessment". Trabalho apresentado em Wyss 7th Annual Retreat, Boston, MA, USA, 2015.
  5. Stephanie Dauth; Thomas Grevesse; Harry Pantazopoulos; Patrick H. Campbell; Maoz, Ben; Sabina Berretta; Kevin Kit Parker. "Unique distribution of ECM proteins in the rodent CNS and their influence on neurite outgrowth: Implications for brain disease in vivo and in vitro models". Trabalho apresentado em Wyss 7th Annual Retreat, Boston, MA, USA, 2015.
  6. Tara Murty; Maoz, Ben; Stephanie Dauth; Sean P. Sheehy; Matthew Hemphill; Thomas Grevesse; Bogdan Budnik; Kevin Kit Parker. "Brain Regions Matter In Vitro and In Vivo: A Proteomics Based Evaluation". Trabalho apresentado em Biomedical Engineering Society, 7- 10 October, 2015, Tampa, Florida, USA, 2015.
  7. Stephanie Dauth; Thomas Grevesse; Harry Pantazopoulos; Patrick H. Campbell; Maoz, Ben; Sabina Berretta; Kevin Kit Parker. "Unique Distribution of ECM Proteins in the Rodent CNS and Their Influence on Neurite Outgrowth". Trabalho apresentado em Biomedical Engineering Society, Tampa, Florida, USA, 2015.
  8. Maoz, Ben; Sung-Jin Park; Borna Dabiri; Matthew Hemphill; Stephanie Dauth; Andrew Capulli; Angie Greer; Kevin Kit Parker. "In Vitro Neuronal Logic Circuits as a Tool for Neuronal Network Functionality Assessment". Trabalho apresentado em Biomedical Engineering Society, Tampa, Florida, USA, 2015.
  9. Stephanie Dauth; Thomas Grevesse; Harry Pantazopoulos; Patrick H. Campbell; Maoz, Ben; Sabina Berretta; Kevin Kit Parker. "Unique distribution of ECM proteins in the rodent CNS and their influence on neurite outgrowth: Implications for brain disease in vivo and in vitro models". Trabalho apresentado em Rat Genetics and Genomics for Psychiatric Disorders and Addiction Workshop, Chicago, USA, 2015.
  10. Maoz, Ben; Sean P. Sheehy; Thomas Grevesse; Stephanie Dauth; Angie Greer; Kevin Kit Parker. "Identifying Potential Pathways and Target Proteins for Head Injury Therapeutics". Trabalho apresentado em Assembly and Disassembly of the Nervous System, Weizmann Institute of Science, Rehovot, Israel, 2014.
  11. Maoz, Ben; Assaf Ben Moshe; Daniel Vestler; Omri Bar Eli; Gil Markovich. "Extraordinary chiroptical effects in planar achiral plasmonic nanohole arrays". Trabalho apresentado em The 3rd International nanotechnology conference & exhibition, David InterContinental Hotel, Tel Aviv, Israel, 2012.
  12. Maoz, Ben; Maya Bar Sadan; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Control of defects and magnetic properties in colloidal MgO Nanosheets". Trabalho apresentado em The 2nd International nanotechnology conference & exhibition, November 8-9, 2010, David InterContinental Hotel, Tel Aviv, Israel, 2010.
  13. Maoz, Ben; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Control of defects and magnetic properties in colloidal MgO nanosheets". Trabalho apresentado em The 29th Israel Vacuum Society,conference on magnetism, crystal growth, photonics, Tel Aviv University, Tel Aviv, Israel., 2010.
  14. Maoz, Ben; Maya Bar Sadan; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Characterization of highly defective MgO Nanosheets". Trabalho apresentado em The 44nd Annual scientific meeting on the Israel microscope society, Tel Aviv University, Tel Aviv, Israel, 2010.
  15. Alexander B. Tesler; Tanya Karakouz; Tatyana A. Bendikov; Maoz, Ben; Alexander Vaskevich; Israel Rubinstein. "Morphology and optical properties of gold islands films formed by annealing of percolated evaporated gold layers". Trabalho apresentado em The 75th Meeting of the Israel Chemical Society, Tel Aviv University, Tel Aviv, Israel, 2010.
  16. Alexander B. Tesler; Tanya Karakouz; Tatyana A. Bendikov; Maoz, Ben; Alexander Vaskevich; Israel Rubinstein. "Morphology and optical properties of gold islands films formed by annealing of percolated evaporated gold layers". Trabalho apresentado em The 14th Israel Materials Engineering Conference, Tel Aviv University, Tel Aviv, Israel, 2009.
  17. Maoz, Ben; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Control of defects and magnetic properties in colloidal MgO particles". Trabalho apresentado em The 14th Israel Materials Engineering Conference, Tel Aviv University, Tel Aviv, Israel, 2009.
  18. Maoz, Ben; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Control of defects and magnetic properties in colloidal MgO particles". Trabalho apresentado em The 28th Israel Vacuum Society, Air Force House, Herzeliya, Israel, 2009.
Resumo em conferência
  1. Maoz, Ben; Yulia Chaikin; Alexander B. Tesler; Omri Bar Elli; Zhiyuan Fan; Alexander O. Govorov; Alexander Vaskevich; Israel Rubinstein; Gil Markovich. "Amplification of chiroptical activity of chiral biomolecules by surface plasmons". Trabalho apresentado em The Dwek School on Nanoplasmonics, Weizmann Institute of Science, 2012.
  2. Maoz, Ben; Assaf Ben Moshe; Daniel Vestler; Omri Bar Eli; Gil Markovich. "Extraordinary chiroptical effects in planar achiral plasmonic nanohole arrays". Trabalho apresentado em The 3rd International nanotechnology conference & exhibition, Tel Aviv, 2012.
  3. Maoz, Ben; Assaf Ben Moshe; Daniel Vestler; Omri Bar Eli; Gil Markovich. "Extraordinary chiroptical effects in planar achiral plasmonic nanohole arrays". Trabalho apresentado em The 15th Israel Materials Engineering Conference, Dead Sea, 2012.
  4. Maoz, Ben; Maya Bar Sadan; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Control of defects and magnetic properties in colloidal MgO Nanosheets". Trabalho apresentado em The 2nd International nanotechnology conference & exhibition, David InterContinental Hotel, Tel Aviv, 2010.
  5. Maoz, Ben; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Control of defects and magnetic properties in colloidal MgO nanosheets". Trabalho apresentado em The 29th Israel Vacuum Society,conference on magnetism, crystal growth, photonics, Tel Aviv University, Tel Aviv, 2010.
  6. Maoz, Ben; Maya Bar Sadan; Einat Tirosh; Inna Popov; Yuri Rosenberg. "Characterization of highly defective MgO Nanosheets". Trabalho apresentado em The 44nd Annual scientific meeting on the Israel microscope society, Tel Aviv University, Tel Aviv, 2010.
  7. Maoz, Ben; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Control of defects and magnetic properties in colloidal MgO nanosheets". Trabalho apresentado em The 6th Workshop, The center for nanoscience & nanotechnology Tel Aviv University, Hecienda Forestview, Maalot, 2010.
  8. Maoz, Ben. "Unusual properties of MgO nanosheets". Trabalho apresentado em The 75th Meeting of the Israel Chemical Society, Tel Aviv University, Tel Aviv, 2010.
  9. Alexander B. Tesler; Tanya Karakouz; Tatyana A. Bendikov; Maoz, Ben; Alexander Vaskevich. "Morphology and optical properties of gold islands films formed by annealing of percolated evaporated gold layers". Trabalho apresentado em The 75th Meeting of the Israel Chemical Society, Tel Aviv University, Tel Aviv, 2010.
  10. Alexander B. Tesler; Tanya Karakouz; Tatyana A. Bendikov; Maoz, Ben; Alexander Vaskevich; Israel Rubinstein. "Morphology and optical properties of gold islands films formed by annealing of percolated evaporated gold layers". Trabalho apresentado em The 14th Israel Materials Engineering Conference, December 13-14, 2009, Tel Aviv University, Tel Aviv, 2009.
  11. Maoz, Ben; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Control of defects and magnetic properties in colloidal MgO particles". Trabalho apresentado em The 14th Israel Materials Engineering Conference, Tel Aviv University, Tel Aviv, 2009.
  12. Maoz, Ben; Einat Tirosh; Inna Popov; Yuri Rosenberg; Gil Markovich. "Control of defects and magnetic properties in colloidal MgO particles". Trabalho apresentado em The 28th Israel Vacuum Society, Air Force House,, Herzeliya, 2009.

Propriedade Intelectual

Patente
  1. Maoz, Ben; Herland, Anna; Henry, Olivier F; Parker, Kevin K; Ingber, Donald E. 2018. "Integrated Multi-Electrode Array and Trans-Endothelial Electrical Resistance In Organ- On-A-Chip Microsystems".
  2. Maoz, Ben. 2016. "Microfluidic Brain Neurovascular System, Devices, and Methods of Use".
  3. Stephanie Dauth; Josue A. Goss; Thomas Grevesse; Maoz, Ben; Kevin Kit Parker. 2015. "Brain In Vitro Models, Devices, Systems, and Methods of Use Thereof".
  4. Maoz, Ben. 2013. "Gold coated electrospun scaffolds".

Outros

Outra produção
  1. Effect of SARS-CoV-2 proteins on vascular permeability. 2021. Rauti, R.; Shahoha, M.; Leichtmann-Bardoogo, Y.; Nasser, R.; Tamir, R.; Miller, V.; Babich, T.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105327962&partnerID=MN8TOARS.
    10.1101/2021.02.27.433186
  2. A robotic platform for fluidically-linked human body-on-chips experimentation. 2019. Novak, R.; Ingram, M.; Clauson, S.; Das, D.; Delahanty, A.; Herland, A.; Maoz, B.M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095642599&partnerID=MN8TOARS.
    10.1101/569541
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/02/25 Organs-On-a-Chip: A New Tool for the Study of Human Physiology ISBME
(Haifa, Israel)
2020/02/15 Organs-On-a-Chip: A New Tool for the Study of Human Physiology ILANIT
(Eilat, Israel)
2020/01/31 Organs-On-a-Chip: A New Tool for the Study of Human Physiology Twente University
(Twente, Países Baixos)
2020/01/30 Organs-On-a-Chip: A New Tool for the Study of Human Physiology IMEC
(Brussels, Bélgica)
2020/01/14 The border between animals and human Atnacta, Ted talk like, Tel Aviv University
(Tel Aviv , Israel)
2020/01/01 Organs-On-a-Chip: A New Tool for the Study of Human Physiology Wingate Institute
(Israel)
2019/12/09 Organs-On-a-Chip: A New Tool for the Study of Human Physiology 17th International conference on biomedical engineering, NUS engineering
(Singapore, Singapura)
2019/12/06 Organs-On-a-Chip: A New Tool for the Study of Human Physiology Seminar in Material Engineering, Technion
(Haifa, Israel)
2019/10/31 Organs-On-a-Chip: A New Tool for the Study of Human Physiology I-NVU: the 1st forum Neurovascular symposium- Porter, Tel Aviv University
(Tel Aviv, Israel)
2019/08/08 Organs-On-a-Chip: A New Tool for the Study of Human Physiology 16th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering and the 4th Conference on Imaging and Visualization, Columbia University
(New York, Estados Unidos)
2019/05/30 Organs-On-a-Chip: A New Tool for the Study of Human Physiology New Technologies for Human Health, Tel Aviv University
(Tel Aviv, Israel)
2019/05/13 Organs-On-a-Chip: A New Tool for the Study of Human Physiology The Gonda Brain Research Center, Bar Ilan University
(Tel Aviv, Israel)
2019/03/19 Organs-On-a-Chip: A New Tool for the Study of Human Physiology Symposium Organs-on-a-Chip, Natural history museum
(Tel Aviv, Israel)
2019/03/17 Organs-On-a-Chip: A New Tool for the Study of Human Physiology Dept. of Cell and Developmental Biology, Tel Aviv University
(Tel Aviv, Israel)
2019/03/13 Organs-On-a-Chip: A New Tool for the Study of Human Physiology The Israel Society of Biological Psychiatry
(Kfar Blum, Israel)
2019/02/25 Organs-On-a-Chip: A New Tool for the Study of Human Physiology Sagol School of Neuroscience, Tel Aviv University
(Jerusalem, Israel)
2019/02/19 Organs-On-a-Chip: A New Tool for the Study of Human Physiology 12th TAU Nano workshop
(Dead Sea, Israel)
2019/02/11 Organs-On-a-Chip: A New Tool for the Study of Human Physiology Freiburg University
(Freiburg, Alemanha)
2018/11/08 Organs-On-a-Chip: A New Tool for the Study of Human Physiology International Organ-on-a-Chip Symposium
(Eindhoven, Países Baixos)
2018/11/01 Organs-On-a-Chip: A New Tool for the Study of Human Physiology International Conference on Life Science Research & its Interface with Engineering and Allied Sciences, BITS
(Pilani, Índia)
2018/10/09 Organs-On-a-Chip: A New Tool for the Study of Human Physiology International Convention Center
(Jerusalem, Israel)
2018/09/09 Organs-On-a-Chip: A New Tool for the Study of Human Physiology Israel Vacuum Society, City tower Hotel
(Tel-Aviv, Israel)
2018/03/15 Organs-On-a-Chip: A New Tool for the Study of Human Physiology MIXIBioMed, 17th National Life Sciences & Technology Week, Dan Panorama Hotel
(Tel-Aviv, Israel)
2018/03/05 Organs-On-a-Chip: A New Tool for the Study of Human Physiology Neural Interfaces- from cellular mechanisms towards clinical application, Bar Ilan University
(Israel)
2017/08/03 Revealing New Physiology with Brain In Vitro Models La Plata University, CONISET
(La Plata, Argentina)
2016/07/05 Novel In Vitro Models for Brain Research The 1st Global innovative GRDC Workshop;, University of Texas at Dallas
(Dallas, Texas, Estados Unidos)
2015/11/29 Living Matter as Building Blocks for Logic Circuits - New Tool for Assessing Neuronal Network Functionality Materials Research Society
(Boston, Massachusetts, Estados Unidos)

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2015 - 2015 Medical Device Development, Harvard Catalyst Education Program, Harvard University, USA
2009/02 - 2009/02 Participated in Electron Holography workshop at the Institute of Structure Physics, Technische, Universitaet Dresden, Germany, directed Prof. H. Lichte

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020 - 2020 Micromachines (2072-666X) MDPI AG

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2020/02 “Human-on-a-Chip” OOC to revolutionise preclinical Longevity technology
2020/01 TAU studies test drug effects with multi-Organ-on-a-Chip platform- Scientists at Tel Aviv University and Harvard University developed the multi-Organ Chip to improve pre-clinical testing. The Jerusalem Post
2020/01 Israel, US researchers create ‘mini Human-on-a-Chip’ to speed up drug testing - Tel Aviv and Harvard University scientists have created and linked up nine Organs-on-a-chip, including brain, heart and liver, paving way for personalized drug development The Times of Israel
2020/01 Enhancing drug testing with human body-on-chip systems - Physiologically linked systems enhance preclinical drug testing, say Harvard-Tel Aviv University researchers EurekAlert-AAAS
2020/01 Enhancing drug testing with human body-on-chip systems MedicalExpress
2020/01 Body-on-chip technology: resolving current limitations in drug discovery -Researchers have developed a new body-on-chip technology that can demonstrate the pharmacokinetics and pharmacodynamics of drugs in a pre-clinical setting without the need for animal testing. Drug Target Review
2020/01 Enhancing Drug Testing With Human Body-on-Chip Systems- Physiologically linked systems enhance preclinical drug testing, say Harvard-TAU researchers Aftu- American Friends of Tel Aviv University
2020/01 ‘Body-on-Chip’ technology could accelerate drug testing" Mirage News
2020/01 Human Body-on-Chip platform enables in vitro prediction of drug behaviors in humans- Fluidically-linked systems of multiple human Organ Chips that quantitatively predict drug pharmacokinetics may offer alternatives to some animal tests Harvard - Wyss
2020/01 Enhancing drug testing with human body-on-chip systems - Physiologically linked systems enhance preclinical drug testing, say Harvard-Tel Aviv University researchers Science Daily
2020/01 Microfluidic Links between Organ Chips Break Preclinical Bottleneck Genegnews
2020/01 Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips. X-mol
2020/01 Chips could accelerate tests for drug safety and effectiveness KTH
2020/01 Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips News Break
2020/01 Human organ chips for better drug development News Medical
2020/01 Predicting Human Drug Pharmacokinetics and Pharmacodynamics using Human Body-on-Chips Technology- Fluidically-coupled Organ Chips recapitulate clinically relevant drug behaviors in humans Bioengineering Comunity - Nature
2020/01 Organ Chip Systems Simulate Full Body Drug Responses Science and enterprise
2020/01 Could a series of linked organ-on-a-chip systems be the future of quantitative pharmacokinetics? Bioanalysis zone
2020/01 Body-on-Chip system mimics the behavior of 10 connected organs New Atlas
2020/01 Device Links Up to 10 Organ Chips to Form Body-on-a-Chip Med Gadget
2020/01 Platform Predicts Various Drug Behaviors In Humans MD India
2020/01 Enhancing drug testing with human body-on-chip systems Tel Aviv - BrainBoost
2020 Boston: Wyss-Institut stellt Human-on-a-Chip mit 10 Organen vor In Vitro Jobs
2019/12 Mieux comprendre le développement d’Alzheimer à l’aide d’un cerveau sur puce-Recruté en 2018 à l’Université de Tel Aviv pour y diriger sa propre équipe, Ben Maoz est l’un des lauréats de la dernière campagne de financement du Conseil européen de la recherche (ERC). Il nous a reçus pour nous présenter son projet de recherche mêlant physiologie cérébrale et ingénierie. France Diplomatie
2019/04 Tel-Aviv University center for nanoscience and nanotechnology Tel Aviv - Global TAU
2018/08 Un chercheur de l'Université de Tel-Aviv développe un cerveau sur une puce permettant de révolutionner la recherche sur les organes humains Les Amis Francies de L'Uuniversite de Tel Aviv
2018/08 This is an artificial brain. This is an artificial brain on meth Yahoo News
2018/08 Taking the brain apart to put it all together again Harvard SEAS Taking the brain apart to put it all together again
2018/08 Taking the brain apart to put it all together again Wyss Institute Taking the brain apart to put it all together again
2018/08 Taking the brain apart to put it all together again- New organ on a chip lets researchers study effects of drugs and disease on the brain and importance of blood vessels Harvard Gazette
2018/08 New scientific model reveals interaction between blood vessels and neurons in the brain Karolinska Institutet
2018/08 Mimicking the Blood-Brain Barrier on a chip to study the effect of neuroactive drugs. Karolinska Institute Medical Center
2018/08 Bryter upp hjärnan i smådelar för att förstå dess funktion KTH
2018/08 Scientists Dosed an Artificial Brain With Meth motherboard
2018/08 Taking the brain apart to put it all together again- Fluidically linked Blood-Brain Barrier and Brain Organ Chips offer new method for studying the effects of drugs and disease on the brain and its blood vessels EurekAlert-AAAS
2018/08 Taking the brain apart to put it all together again ScienceDaily
2018/08 Taking the brain apart to put it all together again Scientifica
2018/08 Fluidically linked blood-brain barrier and Organ Chips offer new method for studying effects of drugs on the brain Medicalxpress
2018/08 Blood Brain Barrier Chip System WorldHealth.net
2018/08 Taking the brain apart to put it all together again What I learned
2018/08 Organ-on-Chip Model Simulates Blood-Brain Barrier Science and enterprise
2018/08 Scientists Dosed an Artificial Brain With Meth The Vice
2018/08 Brain Organ Chips Offer Novel Approach to Studying Drug and Disease Effects - The toxin-filtering blood-brain barrier's role in maintaining the health of the vital organ was analyzed in a Harvard University research study using advanced technology. Interesting Engineering
2018/08 Scientists Dosed an Artificial Brain With Meth - Organ Chip models enable researchers to directly observe physiological processes and responses. Reddit
2018/08 Scientists Dosed an Artificial Brain With Meth - Organ Chip models enable researchers to directly observe physiological processes and responses. 15 Min News
2018/08 New Organ on a Chip Lets Researchers Study Effects of Drugs and Disease Scietechdaily
2018/08 Wyss researchers create model of the BBB-brain interface using microfluidically linked Organ Chips - Fluidically linked Blood-Brain Barrier and Brain Organ Chips offer new method for studying the effects of drugs and disease on the brain and its blood vessels News-Medical
2018/08 Blood-brain barrier replica chip developed by scientists rte
2017/08 Presentaron en La Plata la revolucionaria técnica “Órganos en chips” - Su mentor, el investigador de Harvard Ben Maoz, disertó en la sede local del CONICET sobre sus características y potencialidades Organ-on-a-Chip talk at La Plata University, la Plata, Argentina
2017/08 “Órganos en chips”: innovación tecnológica para una mejor calidad de vida - Ben Maoz, de la Universidad de Harvard, brindará una conferencia sobre los alcances de un proyecto que ofrece nuevas posibilidades para la medicina Organ-on-a-Chip talk at La Plata University, la Plata, Argentina-CICLO “CIENCIA DE IMPACTO”
2017/07 Human Organs-on-Chips technology has been enhanced to non-invasively report cells’ health, electrical activities and differentiation status Wyss Institute’s Organ Chips get smart and go electric
2017/01 Multiregional brain on a chip - Model allows researchers to study how diseases like schizophrenia impact different regions of the brain simultaneously Harvard SEAS Multiregional Brain-on-a-Chip
2017/01 Multiregional brain on a chip - Model allows researchers to study how diseases like schizophrenia impact different regions of the brain simultaneously Wyss Institute Multiregional Brain-on-a-Chip
2017/01 Multiregional brain on a chip - Model allows researchers to study how diseases like schizophrenia impact different regions of the brain simultaneously EurekAlert-AAAS
2017/01 Multiregional Brain on a Chip- - A newly developed brain on a chip models the connectivity between the amygdala, prefrontal cortex and hippocampus. Neuroscience News
2017/01 Multiregional brain on a chip Medical Express
2017/01 Now multiregional brain-on-a-chip to study disorders Free Press Journal
2017/01 Multiregional Brain-on-a-Chip Medical Automation
2017/01 Multiregional brain on a chip- -Multiregional brain on a chip Plus MD

Entrevista / Programa (rádio / tv)

Programa Tema
2020/01 - 2030/01 Gidi Gov and Friends - Radio (Hebrew) Min 6:20- Linked Organs-on-a-Chip
2020/01 - 2030/01 Tel Aviv - Atnachta (TedTalk-Like)
2020/01 - 2020/01 Three who knows - Radio (Hebrew), Min 19:10 -Linked Organs-on-a-Chip
2019/09 - 2019/09 Tel Aviv - Spotify
2019/03 - 2019/03 What happens now - Radio - (Hebrew)
2018/11 - 2018/11 Shlosha She Yodyim - Radio - (Hebrew)
2018/08 - 2018/08 London and Kirshenbaum - TV - (Hebrew). A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
2018/08 - 2018/08 Tochnit Haborker - TV - (Hebrew) A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
2018/01 - 2018/01 "Tomorrow Edition"- Interview With Brain-on-Chips Specialist Dr. Ben Maoz
2013/05 - 2013/05 Tel Aviv University Center for Nanoscience and Nanotechnology Tel Aviv University Center for Nanoscience and Nanotechnology, Introduction
2011 - 2011 Tel Aviv University, Tel Aviv, Israel Defect-Induced Magtetisem, Talk

Membro de associação

Nome da associação Tipo de participação
2019 - Atual European Vascular Biology Organization
2018 - Atual European Organ-on-a-Chip Society
2016 - 2017 Society of Neuroscience
2015 - 2016 Biomedical Engineering Society
2012 - 2013 American Chemical Society
Distinções

Prémio

2016 Harvard-Wyss Technology Development Fellowship (2016-2018)
2013 Represented Israel at the 63rd Lindau Nobel Laureates Meeting
2012 Best talk at the Israel Materials Engineering Conference
2011 David and Paulina Trotzky scholarship for excellent researchers
2010 Best poster prize at the NanoIsrael Conference
2010 Best poster prize at the Israel Microscope Society Conference
2010 "Amazing abstract" award at the Tel Aviv University 6th Nano Workshop
2010 Tel Aviv University Nano-Center scholarship for excellent researchers (2010-2014)
2009 Best poster prize at the Israel Materials Engineering Conference
2009 Best poster prize at the Israel Vacuum Society Conference
2008 Doctoral Scholarship by the Chemistry School of Tel Aviv University (2008-2013)
2008 Emma and Oscar Getz program for excellent students

Outra distinção

2019 Speech at Atnachta “Ted” like talk
2018 Invited for special issue of “Israel Promising Young Scientists”
2018 Speech at excellence M.Sc degree ceremony of Tel Aviv University
2010 Closing speech at the B.Sc and M.Sc degree ceremony of Tel Aviv University