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Célia da Conceição Duarte Cruz. Obtained the Título de Agregado in Neurosciences in 2017/04/21 by Universidade do Porto Faculdade de Medicina. Obtained her Phd - Human Biology in 2006 by Universidade do Porto Faculdade de Medicina, Doutoramento in Biologia Humana in 2006; obtained her Licenciatura in Biology - Applied Animal Biology in 1999/12/17 by Universidade do Porto Faculdade de Ciências. Assistant Professor in Universidade do Porto Faculdade de Medicina. Published 109 articles in journals. Organized 12 event(s). Supervised 6 PhD thesis(es). Supervised 11 MSc dissertation(s) e co-supervised 3. Supervised 3 work(s) of course completion of LSc/BSc. Has received more thant 10 awards and/or honors. Participated as PhD Student Fellow in 1 project(s), Principal investigator in 4 project(s), Researcher in 7 project(s) and Supervisor in 3 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Neurosciences. Hi-index: 26 In her professional activities interacted with 321 collaborator(s) with co-authorship of scientific papers. In her curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Interstitial cystitis; Bladder pain syndrome; biomarkers; adrenoreceptors; overactive bladder; vanilloid receptor; resiniferatoxin; primary afferents; Spinal cord injury; Neurotrophins; Health; Biomedicine; Bioengeneering; Biological Sciences; Neurosciences; Cell and Molecular Biology .
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Identificação

Identificação pessoal

Nome completo
Célia da Conceição Duarte Cruz

Nomes de citação

  • Cruz, Célia
  • Cruz CD

Identificadores de autor

Ciência ID
7119-A7B4-671A
ORCID iD
0000-0001-8922-5713
AuthenticusID
R-000-3MN
Researcher Id
K-3977-2013
Scopus Author Id
16041592200

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Francês Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2017/04/21
Concluído
 Agregação (Título de Agregado)
Universidade do Porto Faculdade de Medicina, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 Aprovado por unanimidade
2006
Concluído
 Biologia Humana (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Faculdade de Medicina, Portugal
"Importância e Função da Cascata Intracelular de Sinal Erk 1/2 em Condições Inflamatória Crónicas" (TESE/DISSERTAÇÃO)
1999/12/17
Concluído
 Biology - Applied Animal Biology (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Contribuição das fibras C no desenvolvimento da instabilidade vesical. Estudo experimental no rato (nota final: 19)" (TESE/DISSERTAÇÃO)
 14
1995
Concluído
 Sciences (Ensino secundário)
Escola Secundaria Filipa De Vilhena, Portugal
"Sem tese." (TESE/DISSERTAÇÃO)
 18
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2013 - Atual Professor Auxiliar (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal
2007 - 2012 Professor Auxiliar (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2007 Assistente Estagiário (Docente Universitário) Universidade do Porto Faculdade de Medicina, Portugal
2003 - 2004 Monitor (Docente Universitário) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2001 - 2004 PhD student - FCT fellowship: SFRH/5826/2001 Fundação para a Ciência e a Tecnologia, Portugal
2000 - 2001 PhD candidate - Gulbenkian Fellowship Fundação Calouste Gulbenkian, Portugal
Projetos

Bolsa

Designação Financiadores
2021/09 - 2025/09 How important is the urethra? Impact of spinal cord injury on the urethra and lower urinary tract function.
UI/BD/151547/2021
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2023 Urinary dysfunction after spinal cord injury: resolving neuronal mechanisms behind neurogenic detrusor overactivity and detrusor-sphincter-dyssynergia
SFRH/BD/135868/2018
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2009 - 2013 The importance of the neurotrophins NGF and BDNF in bladder dysfunction. An experimental study in the rat.
SFRH/ BD/63225/2009
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2010 Interplay between NGF and TRPV1 in an animal model of chronic bladder inflammation
na
Investigador responsável
Universidade do Porto Faculdade de Medicina, Portugal
 Associação Portuguesa de Urologia
Concluído
2008 - 2010 Importance of BDNF in bladder overactivity. Experimental study in the rat
n/a
Investigador responsável
Universidade do Porto Faculdade de Medicina, Portugal
 Associação Portuguesa de Urologia
Concluído
2001/10 - 2004/05 Activação das vias de sinalização intracelular das ERKs 1 e 2 na medula espinhal em modelos de disfunção vesical e articular
SFRH/BD/5826/2001
Investigador
King's College London Wolfson Centre for Age-Related Diseases, Reino Unido

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2023/03/06 - 2026/03/05 The sound of cells: An acoustic platform aiming towards biophysical cell fingerprints for label-free precision medicine
2022.05237.PTDC
10.54499/2022.05237.PTDC
Instituto de Engenharia de Sistemas e Computadores Tecnologia e Ciência, Portugal

Universidade do Porto Faculdade de Medicina, Portugal

Centro Hospitalar Universitário de São João, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - 2025/12/31 Institute for Research and Innovation in Health
LA/P/0070/2020
UID/BIM/04293/2019
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018 - 2021 Restoring pelvic function after SCI combining methods for nerve regeneration, neuro-prostheses and neuroplasticity
n/a
Investigador
King's College London Wolfson Centre for Age-Related Diseases, Reino Unido

Universidade do Porto Faculdade de Medicina, Portugal
Wings for Life Spinal Cord Research Foundation
Em curso
2016/09/01 - 2020/08/31 Novel anti-obesity therapy: melanocortins induction of beige adipocytes
PTDC/BIM-MET/2123/2014
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2016 - 2020/06 Porto Neurosciences and Neurological Disease Research Initiative at i3S – NeuroDrive@i3S
n/a
Investigador
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Em curso
2016 - 2020/06 INSPIReD - Bladder dysfunction after spinal cord Injury: Insights into emergence and management of neurogenic detrusor overactivity and detrusor-phincter dyssynergia
INSPIReD
Investigador responsável
Universidade do Porto Faculdade de Medicina, Portugal
 Santa Casa da Misericórdia de Lisboa
Em curso
2014 - 2020/06 Terapia inovadora anti-obesidade: o efeito das melanocortinas na transdiferenciação de adipócitos brancos em beijes
PTDC/BIM-MET/2123/2014
Investigador
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2014/01/01 - 2014/12/31 Biomarkers and mechanisms of Interstitial Cystitis
EXPL/NEU-SCC/0288/2013
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Faculdade de Medicina, Portugal

Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2012/12/31 Strategic Project - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008 - 2012 InComb - combating incontinence
223234
Investigador
Universidade do Porto Faculdade de Medicina, Portugal
Concluído
2010 - 2011 Effect of Botox in the intramural parasympathetic ganglia of the urinary bladder. Experimental study in the guinea-pig
n/a
Investigador responsável
Universidade do Porto Faculdade de Medicina, Portugal
 Allergan AG
Concluído
2009 - 2010 Bladder structures targeted by Botox
n/a
Investigador
Universidade do Porto Faculdade de Medicina, Portugal
 Allergan AG
Concluído
2005/03/01 - 2008/04/30 Sensory mechanisms of overactive bladder
POCI/SAU-NEU/55983/2004
Universidade do Porto Faculdade de Medicina, Portugal

Hospital de São João, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2004 - 2007 Mecanismos sensitivos da bexiga hiperactiva
POCI/SAUNEU/ 55983/2004
Investigador
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2001/10/01 - 2004/06/30 ROLE AND FUNCTIONAL SIGNIFICANCE OF SIGNALLING CASCADES IN CHRONIC BLADDER DYSFUNCTION
SFRH/BD/5826/2001
 Fundação para a Ciência e a Tecnologia
Concluído
2000 - 2003 Papel dos neurónios sensitivos que expressam os receptores vanilóides em patologias articulares e urinárias
POCTI/32466/NSE/2000
Bolseiro de Doutoramento
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Rodrigues, Adriana Raquel; Salazar, Maria; Rocha-Rodrigues, Sílvia; Gonçalves, Inês; Cruz, Célia; Almeida, Henrique; Magalhães, José; Gouveia, Alexandra. "Alpha-MSH induces ¿browning¿ of subcutaneous white adipose tissue in mice". Trabalho apresentado em European Congress on Obesity (ECO2017), Porto, 2017.
    Publicado • 10.1159/000468958
Artigo em revista
  1. Marta Louçano; Ana Coelho; Sílvia Sousa Chambel; Cristina Prudêncio; Célia Duarte Cruz; Isaura Tavares. "Noradrenergic Pathways Involved in Micturition in an Animal Model of Hydrocephalus—Implications for Urinary Dysfunction". Biomedicines (2024): https://doi.org/10.3390/biomedicines12010215.
    10.3390/biomedicines12010215
  2. Chambel SS; Cruz CD. "Axonal growth inhibitors and their receptors in spinal cord injury: from biology to clinical translation.". Neural regeneration research (2023): http://europepmc.org/abstract/med/37449592.
    10.4103/1673-5374.373674
  3. Michel Wyndaele; Ana Charrua; François Hervé; Patrik Aronsson; Luke Grundy; Vik Khullar; Alan Wein; et al. "Beyond the urothelium: Interplay between autonomic nervous system and bladder inflammation in urinary tract infection, bladder pain syndrome with interstitial cystitis and neurogenic lower urinary tract dysfunction in spinal cord injury—ICI-RS 2023". Neurourology and Urodynamics (2023): https://doi.org/10.1002/nau.25310.
    10.1002/nau.25310
  4. Ramos D; Cruz CD. "Involvement of microglia in chronic neuropathic pain associated with spinal cord injury - a systematic review.". Reviews in the neurosciences (2023): http://europepmc.org/abstract/med/37490300.
    10.1515/revneuro-2023-0031
  5. Daniel H. Pozza; Isaura Tavares; Célia Duarte Cruz; Sara Fonseca. "Spinal Cord Injury and Complications Related to Neuraxial Anaesthesia Procedures: A Systematic Review". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24054665.
    10.3390/ijms24054665
  6. Ana Ferreira; Diogo Nascimento; Célia Duarte Cruz. "Molecular Mechanism Operating in Animal Models of Neurogenic Detrusor Overactivity: A Systematic Review Focusing on Bladder Dysfunction of Neurogenic Origin". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24043273.
    10.3390/ijms24043273
  7. Ana Ferreira; Sílvia Sousa Chambel; António Avelino; Célia Duarte Cruz. "Spinal Cord Injury Causes Marked Tissue Rearrangement in the Urethra—Experimental Study in the Rat". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232415951.
    10.3390/ijms232415951
  8. Sílvia Sousa Chambel; Ana Ferreira; Raquel Oliveira; Rafael Miranda; Luís Vale; Carlos Reguenga; Martin E. Schwab; Célia Duarte Cruz. "Development of Neurogenic Detrusor Overactivity after Thoracic Spinal Cord Injury Is Accompanied by Time-Dependent Changes in Lumbosacral Expression of Axonal Growth Regulators". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23158667.
    10.3390/ijms23158667
  9. Célia Duarte Cruz. "Involvement of nerve growth factor (NGF) in chronic neuropathic pain – a systematic review". Reviews in the Neurosciences 0 0 (2022): http://dx.doi.org/10.1515/revneuro-2022-0037.
    10.1515/revneuro-2022-0037
  10. Chambel, S.; Oliveira, R.; Ferreira, A.; Schwab, M.; Lopes, Antunes T.; Cruz, C.. "The lumbosacral cord repulsive environment does not halt sprouting of bladder afferents and NDO emergence in a NGF concentration-dependent process following spinal cord injury". European Urology (2022): https://publons.com/wos-op/publon/56489878/.
  11. Ferreira, A.; Chambel, S.; Avelino, A.; Antunes Lopes, T.; Duarte Cruz, C.. "Beyond the bladder: Evidence of histological rearrangement and urethral denervation after thoracic spinal cord injury". European Urology (2022): https://publons.com/wos-op/publon/56489880/.
  12. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection.". Developmental cell (2021): https://doi.org/10.1016/j.devcel.2021.12.008.
    10.1016/j.devcel.2021.12.008
  13. Ana Ferreira; Célia Duarte Cruz. "The urethra in continence and sensation: Neural aspects of urethral function". Neurourology and Urodynamics (2021): https://doi.org/10.1002/nau.24632.
    10.1002/nau.24632
  14. Charrua, A.; Mendes, P.; Cruz, C.. "Biomarkers for Bladder Pain Syndrome/Interstitial Cystitis". Current Bladder Dysfunction Reports (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85099197407&partnerID=MN8TOARS.
    10.1007/s11884-020-00626-9
  15. Chambel, S.; Oliveira, R.; Ferreira, A.; Antunes Lopes, T.; Schwab, M.; Cruz, C. D.. "Sprouting of bladder afferents following spinal cord injury is independent from the lumbosacral cord highly repulsive environment". European Urology (2021): https://publons.com/wos-op/publon/56489879/.
  16. Birkhäuser, V.; Liechti, M.D.; Anderson, C.E.; Bachmann, L.M.; Baumann, S.; Baumberger, M.; Birder, L.A.; et al. "TASCI-transcutaneous tibial nerve stimulation in patients with acute spinal cord injury to prevent neurogenic detrusor overactivity: Protocol for a nationwide, randomised, sham-controlled, double-blind clinical trial". BMJ Open 10 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85089553651&partnerID=MN8TOARS.
    10.1136/bmjopen-2020-039164
  17. Chambel, S.S.; Tavares, I.; Cruz, C.D.. "Chronic Pain After Spinal Cord Injury: Is There a Role for Neuron-Immune Dysregulation?". Frontiers in Physiology 11 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85088532927&partnerID=MN8TOARS.
    10.3389/fphys.2020.00748
  18. Oliveira, R.; Coelho, A.; Franquinho, F.; Sousa, M.M.; Cruz, F.; D. Cruz, C.. "Effects of early intravesical administration of resiniferatoxin to spinal cord-injured rats in neurogenic detrusor overactivity". Neurourology and Urodynamics 38 6 (2019): 1540-1550. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069728890&partnerID=MN8TOARS.
    10.1002/nau.24032
  19. Coelho, A.; Charrua, A.; Oliveira, R.; Cavaleiro, H.; Cruz, C.D.; Cruz, F.. "Underactive bladder in aging rats is associated with a reduced number of serotonin-expressing cells in the urethra and is improved by serotonin application to the urethra". LUTS: Lower Urinary Tract Symptoms (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068170755&partnerID=MN8TOARS.
    10.1111/luts.12273
  20. Coelho, A.; Oliveira, R.; Antunes-Lopes, T.; Cruz, C.D.. "Partners in crime: Ngf and bdnf in visceral dysfunction". Current Neuropharmacology 17 11 (2019): 1021-1038. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073579994&partnerID=MN8TOARS.
    10.2174/1570159x17666190617095844
  21. Cruz, Célia; Coelho, A.; Oliveira, R.; Cavaleiro, H.; Cruz, C.D.; Cruz, F.. "Evidence for an urethro-vesical crosstalk mediated by serotonin.". Neurourol and Urodynamics 37 8 (2018): 2389-2397. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045723405&partnerID=MN8TOARS.
    10.1002/nau.23590
  22. Coelho, A.; Morgado, A.; Oliveira, R.; Cruz, C. D.; Charrua, A.; Cruz, F.. "AGING ASSOCIATED UNDERACTIVE BLADDER INVOLVES A DECREASE IN URETHRAL SEROTONIN RELEASED BY 5HT-EXPRESSING CELLS. AN EXPERIMENTAL STUDY IN RAT". Neurourology and Urodynamics (2018): https://publons.com/wos-op/publon/28317138/.
  23. Cavaleiro, H.; Oliveira, R.; Coelho, A.; Cruz, F.; Duarte Cruz, C.. "BLADDER DYSFUNCTION TREATMENT IN AN ANIMAL MODEL OF MULTIPLE SCLEROSIS". Neurourology and Urodynamics (2018): https://publons.com/wos-op/publon/18439249/.
  24. Coelho, A.; Oliveira, R.; Cavaleiro, H.; Cruz, C. D.; Cruz, F.. "URETHRAL SEROTONIN STIMULATES AN URETHRO-VESICAL REFLEX". Neurourology and Urodynamics (2018): https://publons.com/wos-op/publon/28317139/.
  25. Chambel, S. S.; Oliveira, R.; Schwab, M.; Cruz, C. D.. "CHANGES IN EXPRESSION OF GROWTH INHIBITORY PROTEINS AT THE LUMBOSACRAL CORD ARE ASSOCIATED WITH SPROUTING OF SENSORY AFFERENTS AFTER THORACIC SPINAL CORD INJURY". Neurourology and Urodynamics (2018): https://publons.com/wos-op/publon/18439248/.
  26. Cruz, Célia; Rodrigues, A.R.; Salazar, M.J.; Rocha-Rodrigues, S.; Gonçalves, I.O.; Cruz, C.; Neves, D.; et al. "Peripherally administered melanocortins induce mice fat browning and prevent obesity.". International Journal of Obesity 43 5 (2017): 1058-1069. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049928815&partnerID=MN8TOARS.
    10.1038/s41366-018-0155-5
  27. Antunes-Lopes, T.; Coelho, A.; Pinto, R.; Barros, S.C.; Cruz, C.D.; Cruz, F.; Silva, C.M.. "Author Reply". Urology 99 (2017): 55-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006874618&partnerID=MN8TOARS.
    10.1016/j.urology.2016.08.050
  28. Antunes-Lopes, T.; Coelho, A.; Pinto, R.; Barros, S.C.; Cruz, C.D.; Cruz, F.; Silva, C.M.. "Urinary Neurotrophin Levels Increase in Women With Stress Urinary Incontinence After a Midurethral Sling Procedure". Urology 99 (2017): 49-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006248627&partnerID=MN8TOARS.
    10.1016/j.urology.2016.08.048
  29. Coelho, Ana; Oliveira, Raquel; Cavaleiro, Helena; Cruz, Celia Duarte; Cruz, Francisco. "EXPRESSION AND FUNCTION OF SEROTONIN PARANEURONAL CELLS IN THE URETHRAL EPITHELIUM OF HUMAN AND RODENTS". Journal of Urology (2017): https://publons.com/wos-op/publon/11441504/.
    10.1016/J.JURO.2017.02.1295
  30. Coelho, A.; Oliveira, R.; Serrao, P.; Cruz, D. C.; Cruz, F.. "DISTRIBUTION AND FUNCTION OF CELLS EXPRESSING SEROTONIN IN THE LOWER URINARY TRACT OF NORMAL AND INFLAMED RATS". Neurourology and Urodynamics (2017): https://publons.com/wos-op/publon/11441506/.
  31. Coelho A; Oliveira R; Cruz F; Cruz CD. "Impairment of sensory afferents by intrathecal administration of Botulinum Toxin A improves neurogenic detrusor overactivity in chronic spinal cord injured rats.". (2016): http://europepmc.org/abstract/med/27235935.
    10.1016/j.expneurol.2016.05.029
  32. B. Frias; J.P. Santos; S. Allen; F. Cruz; C.D. Cruz. "1085 BDNF prevents the appearance of neurogenic detrusor overactivity (NDO) following spinal cord injury". European Urology Supplements 14 2 (2015): e1085-e1085a. http://dx.doi.org/10.1016/s1569-9056(15)61073-9.
    10.1016/s1569-9056(15)61073-9
  33. B. Frias; J. Santos; M. Morgado; M. M. Sousa; S. M. Y. Gray; K. D. McCloskey; S. Allen; F. Cruz; C. D. Cruz. "The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Development of Neurogenic Detrusor Overactivity (NDO)". Journal of Neuroscience 35 5 (2015): 2146-2160. http://dx.doi.org/10.1523/jneurosci.0373-14.2015.
    10.1523/JNEUROSCI.0373-14.2015
  34. A Coelho; A S Wolf-Johnston; S Shinde; C D Cruz; F Cruz; A Avelino; L A Birder. "Urinary bladder inflammation induces changes in urothelial nerve growth factor and TRPV1 channels". Br J Pharmacol 172 7 (2015): 1691-1699. http://dx.doi.org/10.1111/bph.12958.
    10.1111/bph.12958
  35. Ana Charrua; Célia D. Cruz; Dick Jansen; Boy Rozenberg; John Heesakkers; Francisco Cruz. "Co-administration of transient receptor potential vanilloid 4 (TRPV4) and TRPV1 antagonists potentiate the effect of each drug in a rat model of cystitis". BJU Int 115 3 (2015): 452-460. http://dx.doi.org/10.1111/bju.12861.
    10.1111/bju.12861
  36. Célia Duarte Cruz; Ana Coelho; Tiago Antunes-Lopes; Francisco Cruz. "Biomarkers of spinal cord injury and ensuing bladder dysfunction". Advanced Drug Delivery Reviews (2014): http://dx.doi.org/10.1016/j.addr.2014.11.007.
    10.1016/j.addr.2014.11.007
  37. Antunes-Lopes T; Cruz CD; Cruz F; Sievert KD. "Biomarkers in lower urinary tract symptoms/overactive bladder: a critical overview.". (2014): http://europepmc.org/abstract/med/24841379.
    10.1097/mou.0000000000000064
  38. Pinto R; Lopes T; Costa D; Barros S; Silva J; Silva C; Cruz C; Dinis P; Cruz F. "Ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis do not differ in symptom intensity or response to onabotulinum toxin A.". (2014): http://europepmc.org/abstract/med/24767520.
    10.1016/j.urology.2014.01.018
  39. Tiago Antunes-Lopes; Daniel Costa; Rui Pinto; Sérgio Carvalho-Barros; Carlos Martins-Silva; Célia Duarte-Cruz; Francisco Cruz. "MP76-06 URINARY NEUROTROPHINS AND QMAX VARIATION MAY PREDICT DE NOVO URGENCY IN SUI PATIENTS AFTER A MIDURETHRAL SLING (MUS) SURGERY". The Journal of Urology 191 4 (2014): e884-e884. http://dx.doi.org/10.1016/j.juro.2014.02.2399.
    10.1016/j.juro.2014.02.2399
  40. A. Coelho; R. Oliveira; O. Rossetto; C.D. Cruz; F. Cruz; A. Avelino. "696 Can intrathecal botulinum toxin delivery be used to relieve severe bladder pain?". European Urology Supplements 13 1 (2014): e696-e696. http://dx.doi.org/10.1016/s1569-9056(14)60686-2.
    10.1016/s1569-9056(14)60686-2
  41. Coelho, A.; Oliveira, R.; Rossetto, O.; Cruz, C.D.; Cruz, F.; Avelino, A.. "Intrathecal administration of botulinum toxin type A improves urinary bladder function and reduces pain in rats with cystitis". European Journal of Pain (United Kingdom) 18 10 (2014): 1480-1489. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908481214&partnerID=MN8TOARS.
    10.1002/ejp.513
  42. Célia Duarte Cruz. "Neurotrophins in bladder function: What do we know and where do we go from here?". Neurourol. Urodynam. 33 1 (2013): 39-45. http://dx.doi.org/10.1002/nau.22438.
    10.1002/nau.22438
  43. A. Coelho; A.S. Wolf-Johnston; S. Shinde; A. Avelino; C.D. Cruz; F. Cruz; L. Birder. "65 Role of NGF in bladder inflammation-induced pain behavior and TRPV1 traffic". European Urology Supplements 12 1 (2013): e65-e65. http://dx.doi.org/10.1016/s1569-9056(13)60558-8.
    10.1016/s1569-9056(13)60558-8
  44. Frias B; Allen S; Dawbarn D; Charrua A; Cruz F; Cruz CD. "Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation.". (2013): http://europepmc.org/abstract/med/23313710.
    10.1016/j.neuroscience.2012.12.044
  45. Tiago Antunes-Lopes; Rui Pinto; Sérgio C. Barros; Francisco Botelho; Carlos M. Silva; Célia D. Cruz; Francisco Cruz. "Urinary Neurotrophic Factors in Healthy Individuals and Patients with Overactive Bladder". The Journal of Urology 189 1 (2013): 359-365. http://dx.doi.org/10.1016/j.juro.2012.08.187.
    10.1016/j.juro.2012.08.187
  46. Ana Charrua; Rui Pinto; Anna Taylor; André Canelas; Alfredo Ribeiro-da-Silva; Célia D. Cruz; Lori Ann Birder; Francisco Cruz. "Can the adrenergic system be implicated in the pathophysiology of bladder pain syndrome/interstitial cystitis? A clinical and experimental study". Neurourol. Urodynam. (2013): n/a-n/a. http://dx.doi.org/10.1002/nau.22542.
    10.1002/nau.22542
  47. Coelho, A.; Carneiro, A.; Oliveira, R.; Cruz, F.; Cruz, C. D.; Avelino, A.. "EFFECT OF INTRATHECAL BOTULINUM TOXIN TYPE A IN PAIN ASSOCIATED WITH CHEMICAL-INDUCED CYSTITIS". Neurourology and Urodynamics (2013): https://publons.com/wos-op/publon/5828832/.
  48. Frias, B.; Santos, J.; Allen, S.; Cruz, F.; Cruz, C. D.. "ROLE OF BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) IN NEUROGENIC DETRUSOR OVERACTIVITY (NDO)". Neurourology and Urodynamics (2013): https://publons.com/wos-op/publon/5828795/.
  49. A. Avelino; A. Charrua; B. Frias; C. Cruz; M. Boudes; D. de Ridder; F. Cruz. "Transient receptor potential channels in bladder function". Acta Physiol 207 1 (2012): 110-122. http://dx.doi.org/10.1111/apha.12021.
    10.1111/apha.12021
  50. Ochodnicky P; Cruz CD; Yoshimura N; Cruz F. "Neurotrophins as regulators of urinary bladder function.". (2012): http://europepmc.org/abstract/med/23045265.
    10.1038/nrurol.2012.178
  51. Ana Coelho; Francisco Cruz; Célia D. Cruz; António Avelino. "Reply from Authors re: Prokar Dasgupta. Volume Matters: Bladder Injections of Botulinum Toxin Type A. Eur Urol 2012;61:1185–6". European Urology 61 6 (2012): 1186-1187. http://dx.doi.org/10.1016/j.eururo.2012.03.009.
    10.1016/j.eururo.2012.03.009
  52. Ana Coelho; Francisco Cruz; Célia D. Cruz; António Avelino. "Spread of OnabotulinumtoxinA After Bladder Injection. Experimental Study Using the Distribution of Cleaved SNAP-25 as the Marker of the Toxin Action". European Urology 61 6 (2012): 1178-1184. http://dx.doi.org/10.1016/j.eururo.2012.01.046.
    10.1016/j.eururo.2012.01.046
  53. Rui Pinto; Tiago Lopes; Sérgio Barros; João Silva; Paulo Dinis; Célia Cruz; Francisco Cruz. "817 URINARY NEUROTROPHIC FACTORS IN BLADDER PAIN SYNDROME/INTERSTITIAL CYSTITIS". The Journal of Urology 187 4 (2012): e333-e334. http://dx.doi.org/10.1016/j.juro.2012.02.907.
    10.1016/j.juro.2012.02.907
  54. Tiago Antunes-Lopes; Rui Pinto; Sérgio Carvalho-Barros; Francisco Botelho; Paulo Diniz; Carlos Martins-Silva; Célia Duarte-Cruz; Francisco Cruz. "1968 THE ROLE OF URINARY NEUROTROPHIC FACTORS IN OVERACTIVE BLADDER SYNDROME". The Journal of Urology 187 4 (2012): e794-e794. http://dx.doi.org/10.1016/j.juro.2012.02.2127.
    10.1016/j.juro.2012.02.2127
  55. Ana Coelho; Francisco Cruz; Célia D. Cruz; António Avelino. "Effect of OnabotulinumtoxinA on Intramural Parasympathetic Ganglia: An Experimental Study in the Guinea Pig Bladder". The Journal of Urology 187 3 (2012): 1121-1126. http://dx.doi.org/10.1016/j.juro.2011.10.130.
    10.1016/j.juro.2011.10.130
  56. A. Charrua; M. Boudes; Ridder D. De; C.D. Cruz; F. Cruz. "366 TRPV1 and TRPV4 expression in bladder neurons during normal condition and during cystitis". European Urology Supplements 11 1 (2012): e366-e366. http://dx.doi.org/10.1016/s1569-9056(12)60363-7.
    10.1016/s1569-9056(12)60363-7
  57. B. Frias; A. Charrua; J. Santos; S. Allen; F. Cruz; C. Cruz. "368 BDNF sequestration improves bladder function in spinal cord injured animals". European Urology Supplements 11 1 (2012): e368-e368. http://dx.doi.org/10.1016/s1569-9056(12)60365-0.
    10.1016/s1569-9056(12)60365-0
  58. A. Charrua; C.D. Cruz; F. Cruz. "365 TRPV1 and TRPV4 antagonists have synergistic effect for treating bladder overactivity in rats". European Urology Supplements 11 1 (2012): e365-e365. http://dx.doi.org/10.1016/s1569-9056(12)60362-5.
    10.1016/s1569-9056(12)60362-5
  59. André Santos-Silva; Ana Charrua; Célia D. Cruz; Laxmikant Gharat; António Avelino; Francisco Cruz. "Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist". Autonomic Neuroscience 166 1-2 (2012): 35-38. http://dx.doi.org/10.1016/j.autneu.2011.09.005.
    10.1016/j.autneu.2011.09.005
  60. Antunes-Lopes, T.; Pinto, R.; Carvalho-Barros, S.; Botelho, F.; Diniz, P.; Martins-Silva, C.; Duarte-Cruz, C.; Cruz, F.. "993 High urinary levels of nerve growth factor and brain-derived neurotrophic factor in women with overactive bladder syndrome normalize after lifestyle intervention and antimuscarinic therapy". European Urology Supplements 11 1 (2012): e993-e993a. http://dx.doi.org/10.1016/S1569-9056(12)60989-0.
    10.1016/s1569-9056(12)60989-0
  61. Frias, B.; Charrua, A.; Avelino, A.; Michel, M.C.; Cruz, F.; Cruz, C.D.; Barbara Frias; et al. "Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input.". BJU international 110 8 Pt B (2012): E422-E428. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027938481&partnerID=MN8TOARS.
    10.1111/j.1464-410x.2012.11187.x
  62. Tiago Antunes-Lopes; Rui Pinto; Sérgio Carvalho-Barros; Paulo Dinis; Carlos Martins-Silva; Célia Duarte-Cruz; Francisco Cruz. "1952 URINARY NEUROTROPHINS – POTENTIAL BIOMARKERS OF OVERACTIVE BLADDER". The Journal of Urology 185 4 (2011): e780-e781. http://dx.doi.org/10.1016/j.juro.2011.02.2156.
    10.1016/j.juro.2011.02.2156
  63. A.C. Coelho; F. Cruz; C.D. Cruz; A. Avelino. "575 SPREAD OF ONABOTULINUM A AFTER INJECTION IN THE BLADDER WALL. EXPERIMENTAL STUDY IN GUINEA-PIG URINARY BLADDER USING THE DISTRIBUTION OF CLEAVED SNAP-25". European Urology Supplements 10 2 (2011): 189-189. http://dx.doi.org/10.1016/s1569-9056(11)60565-4.
    10.1016/s1569-9056(11)60565-4
  64. B. Frias; F. Cruz; C.D. Cruz. "826 NERVE GROWTH FACTOR (NGF) AND BRAIN DERIVED NEUROTROPIC FACTOR (BDNF) PLAY COMPLEMENTARY ROLES IN BLADDER CONTROL". European Urology Supplements 10 2 (2011): 261-261. http://dx.doi.org/10.1016/s1569-9056(11)60812-9.
    10.1016/s1569-9056(11)60812-9
  65. A. Charrua; R. Pinto; A.M. Taylor; S. Barros; A. Ribeiro-Da-Silva; C.D. Cruz; A. Avelino; F. Cruz. "974 AUTONOMIC SYMPATHETIC NERVOUS SYSTEM ACTIVITY IS ENHANCED DURING CHRONIC INFLAMMATION AND CONTRIBUTES TO BLADDER HYPERACTIVITY AND PAIN". European Urology Supplements 10 2 (2011): 304-304. http://dx.doi.org/10.1016/s1569-9056(11)60956-1.
    10.1016/s1569-9056(11)60956-1
  66. Cruz, Célia. "813 INCREASED SYMPATHETIC ACTIVITY ENHANCES BLADDER HYPERACTIVITY AND TRIGGERS BLADDER PAIN". (2011):
    10.1016/j.juro.2011.02.631
  67. Antunes-Lopes, T.; Pinto, R.; Carvalho-Barros, S.; Diniz, P.; Martins-Silva, C.; Duarte-Cruz, C.; Cruz, F.. "883 URINARY LEVELS OF BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) IN WOMEN WITH OVERACTIVE BLADDER (OAB) SYNDROME CORRELATE WITH THE SEVERITY OF SYMPTOMS". European Urology Supplements 10 2 (2011): 277-278. http://dx.doi.org/10.1016/S1569-9056(11)60867-1.
    10.1016/s1569-9056(11)60867-1
  68. Peter Ochodnický; Célia D. Cruz; Naoki Yoshimura; Martin C. Michel. "Nerve growth factor in bladder dysfunction: Contributing factor, biomarker, and therapeutic target". Neurourol. Urodyn. (2011): n/a-n/a. http://dx.doi.org/10.1002/nau.21022.
    10.1002/nau.21022
  69. Duarte Cruz, Celia. "Editorial [Hot Topic: An Update on Neurotrophins (Guest Editor: Celia Duarte Cruz)]". Current Neuropharmacology 9 4 (2011): 522-522. http://dx.doi.org/10.2174/157015911798376280.
    10.2174/157015911798376280
  70. Barbara Frias; Tiago Lopes; Rui Pinto; Francisco Cruz; Celia Duarte Cruz; Frias, B.; Lopes, T.; et al. "Neurotrophins in the Lower Urinary Tract: Becoming of Age". CN 9 4 (2011): 553-558. http://dx.doi.org/10.2174/157015911798376253.
    10.2174/157015911798376253
  71. Antunes-Lopes, T.; Pinto, R.; Carvalho-Barros, S.; Diniz, P.; Duarte-Cruz, C.; Martins-Silva, C.; Cruz, F.. "UP-03.200 Brain-Derived Neurotropic Factor: A New Potential Biomarker of Overactive Bladder Syndrome". Urology 78 3 (2011): S411-S411. http://dx.doi.org/10.1016/j.urology.2011.07.1288.
    10.1016/j.urology.2011.07.1288
  72. Tiago Antunes-Lopes; Sérgio Carvalho-Barros; Célia-Duarte Cruz; Francisco Cruz; Carlos Martins-Silva. "Biomarkers in Overactive Bladder: A New Objective and Noninvasive Tool?". Advances in Urology 2011 (2011): 1-7. http://dx.doi.org/10.1155/2011/382431.
    10.1155/2011/382431
  73. Célia Duarte Cruz; Francisco Cruz. "Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem". The Scientific World JOURNAL 11 (2011): 214-234. http://dx.doi.org/10.1100/tsw.2011.26.
    10.1100/tsw.2011.26
  74. Cruz, C.D.. "An update on neurotrophins". Current Neuropharmacology 9 4 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-82955249829&partnerID=MN8TOARS.
  75. White, J.P.M.; Ko, C.W.; Fidalgo, A.R.; Cibelli, M.; Paule, C.C.; Anderson, P.J.; Cruz, C.; et al. "Severe burn injury induces a characteristic activation of extracellular signal-regulated kinase 1/2 in spinal dorsal horn neurons". European Journal of Pain 15 7 (2011): 683-690. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960907909&partnerID=MN8TOARS.
    10.1016/j.ejpain.2010.12.006
  76. Morgado, C.; Pereira-Terra, P.; Cruz, C.D.; Tavares, I.. "Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) at the spinal cord". Diabetes, Obesity and Metabolism 13 2 (2011): 150-159. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650633484&partnerID=MN8TOARS.
    10.1111/j.1463-1326.2010.01333.x
  77. Cristofaro, Vivian; Cruz, Celia D.; Lowalekar, Samar; Mhaskar, Soumil; Yalla, Subbarao V.; Sullivan, Maryrose P.; Cruz, Francisco. "NGF INDUCED SIGNALING IN THE BLADDER IS MODULATED BY CAVEOLAE". Neurourology and Urodynamics (2011): https://publons.com/wos-op/publon/5828908/.
  78. Rui Pinto; Tiago Lopes; Bárbara Frias; André Silva; João Alturas Silva; Carlos Martins Silva; Célia Cruz; et al. "Trigonal Injection of Botulinum Toxin A in Patients with Refractory Bladder Pain Syndrome/Interstitial Cystitis". European Urology 58 3 (2010): 360-365. http://dx.doi.org/10.1016/j.eururo.2010.02.031.
    10.1016/j.eururo.2010.02.031
  79. Ana Coelho; Paolo Dinis; Rui Pinto; Tiago Gorgal; Carlos Silva; André Silva; João Silva; et al. "Distribution of the High-Affinity Binding Site and Intracellular Target of Botulinum Toxin Type A in the Human Bladder". European Urology 57 5 (2010): 884-890. http://dx.doi.org/10.1016/j.eururo.2009.12.022.
    10.1016/j.eururo.2009.12.022
  80. A. Coelho; F. Cruz; C. Cruz; A. Avelino. "85 BOTULINUM TOXIN TYPE AACTS ON BLADDER INTRAMURAL PARASYMPATHETIC GANGLIA. AN EXPERIMENTAL STUDY IN THE GUINEA-PIG". European Urology Supplements 9 2 (2010): 59-59. http://dx.doi.org/10.1016/s1569-9056(10)60091-7.
    10.1016/s1569-9056(10)60091-7
  81. R. Pinto; B. Frias; S. Allen; D. Dawbarn; S.B. McMahon; F. Cruz; C.D. Cruz. "Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis". Neuroscience 166 3 (2010): 907-916. http://dx.doi.org/10.1016/j.neuroscience.2010.01.015.
    10.1016/j.neuroscience.2010.01.015
  82. Cruz, Célia. "1677 INTRA-TRIGONAL INJECTION OF BOTULINUM TOXIN A IN PATIENTS WITH REFRACTORY BLADDER PAIN SYNDROME DECREASES URINARY NEUROTROPHINS AND IMPROVES LOWER URINARY TRACT SYMPTOMS". (2010):
    10.1016/j.juro.2010.02.1502
  83. Coelho, Ana; Cruz, Francisco; D. Cruz, Celia; Avelino, Antonio. "191 EFFECT OF BOTULINUM TOXIN TYPE A ON INTRAMURAL PARASYMPATHETIC GANGLIA OF THE GUINEA-PIG BLADDER". The Journal of Urology 183 4 (2010): e76-e76. http://dx.doi.org/10.1016/j.juro.2010.02.247.
    10.1016/j.juro.2010.02.247
  84. Pinto, Rui Almeida; Frias, Barbara; Lopes, Tiago; Silva, Andre; Silva, Joao Alturas; Silva, Carlos Santos; Dinis, Paulo; Cruz, Celia; Cruz, Francisco. "INTRA-TRIGONAL INJECTION OF BOTULINUM TOXIN A IN PATIENTS WITH REFRACTORY BLADDER PAIN SYNDROME DECREASES URINARY NEUROTROPHINS AND IMPROVES LOWER URINARY TRACT SYMPTOMS". Journal of Urology (2010): https://publons.com/wos-op/publon/28317159/.
  85. C. Cruz; B. Frias; R. Pinto; S. Allen; D. Dawbarn; F. Cruz. "654 INTRATHECAL BDNF SEQUESTRATION REDUCES REFERRED PAIN AND BLADDER OVERACTIVITY IN AN ANIMAL MODEL OF CHRONIC BLADDER INFLAMMATION". European Journal of Pain 13 (2009): S189-S189. http://dx.doi.org/10.1016/s1090-3801(09)60657-1.
    10.1016/s1090-3801(09)60657-1
  86. A. Coelho; P. Dinis; R. Pinto; T. Gorgal; C. Silva; A. Silva; J. Silva; et al. "258 DISTRIBUTION AND NEUROCHEMISTRY OF BOTULINUM TOXIN TYPE A RECEPTORS IN THE URINARY BLADDER". European Journal of Pain 13 (2009): S81-S81. http://dx.doi.org/10.1016/s1090-3801(09)60261-5.
    10.1016/s1090-3801(09)60261-5
  87. R. Pinto; T. Lopes; C. Cruz; J. Silva; C. Silva; F. Cruz; P. Dinis. "652 CHEMICAL NEUROMODULATION IN PATIENTS WITH BLADDER PAIN SYNDROME (BPS)". European Journal of Pain 13 (2009): S189-S189. http://dx.doi.org/10.1016/s1090-3801(09)60655-8.
    10.1016/s1090-3801(09)60655-8
  88. B. Frias; R. Pinto; S. Allen; D. Dawbarn; F. Cruz; C. Cruz. "653 INTRATHECAL BLOCKADE OF NGF DECREASES REFERRED PAIN IN RATS MODEL OF CHRONIC BLADDER INFLAMMATION". European Journal of Pain 13 (2009): S189-S189. http://dx.doi.org/10.1016/s1090-3801(09)60656-x.
    10.1016/s1090-3801(09)60656-x
  89. A. Coelho; P. Dinis; R. Pinto; T. Gorgal; C. Silva; A. Andre; J. Joao; et al. "223 DISTRIBUTION AND NEUROCHEMISTRY OF HIGH AFFINITY BINDING SITES FOR BOTULINUM TOXIN TYPE A IN THE URINARY BLADDER". European Urology Supplements 8 4 (2009): 176-176. http://dx.doi.org/10.1016/s1569-9056(09)60228-1.
    10.1016/s1569-9056(09)60228-1
  90. R. Pinto; B. Frias; S. Allen; D. Dawbarn; S. McMahon; F. Cruz; C. Cruz. "603 SEQUESTRATION OF BDNF WITH A RECOMBINANT PROTEIN IMPROVES BLADDER FUNCTION IN RATS WITH CHRONIC BLADDER INFLAMMATION". European Urology Supplements 8 4 (2009): 271-271. http://dx.doi.org/10.1016/s1569-9056(09)60598-4.
    10.1016/s1569-9056(09)60598-4
  91. Ana Charrua; Célia D. Cruz; Shridhar Narayanan; Laxmikant Gharat; Srinivas Gullapalli; Francisco Cruz; António Avelino. "GRC-6211, a New Oral Specific TRPV1 Antagonist, Decreases Bladder Overactivity and Noxious Bladder Input in Cystitis Animal Models". The Journal of Urology 181 1 (2009): 379-386. http://dx.doi.org/10.1016/j.juro.2008.08.121.
    10.1016/j.juro.2008.08.121
  92. Cruz, Célia. "HIGH AFFINITY BINDING SITES FOR BOTULINUM TOXIN TYPE A IN THE URINARY BLADDER: DISTRIBUTION AND NEUROCHEMISTRY". (2009):
    10.1016/s0022-5347(09)60431-6
  93. Frias, B.; Charrua, A.; Pinto, R.; Allen, S.; Dawbarn, D.; Cruz, F.; Cruz, C. D.. "INTRATHECAL BLOCKADE OF TRK RECEPTOR AND NEUROTROPHINS SEQUESTRATION REDUCES PAIN AND URINARY FREQUENCY IN AN ANIMAL MODEL OF CHRONIC BLADDER INFLAMMATION". Neurourology and Urodynamics (2009): https://publons.com/wos-op/publon/5828796/.
  94. Charrua, A.; Pinto, R.; Frias, B.; Cruz, C. D.; Cruz, F.. "TRPV1 EXPRESSION IN THE BLADDER IS ESSENTIAL FOR NGF-INDUCED DETRUSOR OVERACTIVITY". Neurourology and Urodynamics (2009): https://publons.com/wos-op/publon/5828801/.
  95. Charrua, A.; Silva, A.; Cruz, C.; Avelino, A.; Cruz, F.. "TRPV1 in genito-urinary disorders". Neuropeptides (2009): https://publons.com/wos-op/publon/5828903/.
  96. F. Cruz; A. Charrua; C. Cruz; L. Gharat; S. Gullapalli; S. Narayanan; A. Avelino. "GRC 6211, A NEW ORAL TRPV1 ANTAGONIST, DECREASES THE FREQUENCY OF BLADDER REFLEX CONTRACTIONS AND NOXIOUS INPUT IN RATS WITH ACUTE OR CHRONIC CYSTITIS". European Urology Supplements 7 3 (2008): 181-181. http://dx.doi.org/10.1016/s1569-9056(08)60440-6.
    10.1016/s1569-9056(08)60440-6
  97. Cruz, Francisco; Charrua, Ana; Cruz, Celia; Narayanan, Shridhar; Gharat, Laxmikant; Gullapalli, Srinivas; Avelino, Antonio. "THE ORAL TRPV1 ANTAGONIST GRC 6211 REDUCES BLADDER OVERACTIVITY AND NOXIOUS BLADDER INPUT IN CYSTITIS". The Journal of Urology 179 4 (2008): 539-539. http://dx.doi.org/10.1016/S0022-5347(08)61584-0.
    10.1016/s0022-5347(08)61584-0
  98. Célia D. Cruz; Ana Charrua; Eva Vieira; João Valente; António Avelino; Francisco Cruz. "Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals". Experimental Neurology 214 2 (2008): 301-308. http://dx.doi.org/10.1016/j.expneurol.2008.08.016.
    10.1016/j.expneurol.2008.08.016
  99. Ana Charrua; Célia D. Cruz; Francisco Cruz; António Avelino. "Transient Receptor Potential Vanilloid Subfamily 1 is Essential for the Generation of Noxious Bladder Input and Bladder Overactivity in Cystitis". The Journal of Urology 177 4 (2007): 1537-1541. http://dx.doi.org/10.1016/j.juro.2006.11.046.
    10.1016/j.juro.2006.11.046
  100. Célia D. Cruz; Daniel Ferreira; Stephen B. Mcmahon; Francisco Cruz. "The activation of the ERK pathway contributes to the spinal c- fos expression observed after noxious bladder stimulation". Somatosens Mot Res 24 1-2 (2007): 15-20. http://dx.doi.org/10.1080/08990220601143265.
    10.1080/08990220601143265
  101. Celia Cruz; Francisco Cruz. "The ERK 1 and 2 Pathway in the Nervous System: From Basic Aspects to Possible Clinical Applications in Pain and Visceral Dysfunction". CN 5 4 (2007): 244-252. http://dx.doi.org/10.2174/157015907782793630.
    10.2174/157015907782793630
  102. Ferreira, J.G.; Cruz, C.D.; Neves, D.; Pignatelli, D.. "Increased extracellular signal regulated kinases phosphorylation in the adrenal gland in response to chronic ACTH treatment". Journal of Endocrinology 192 3 (2007): 647-658. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947375684&partnerID=MN8TOARS.
    10.1677/joe.1.06961
  103. Célia D. Cruz; Stephen B. McMahon; Francisco Cruz. "Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats". Experimental Neurology 200 1 (2006): 66-73. http://dx.doi.org/10.1016/j.expneurol.2006.01.016.
    10.1016/j.expneurol.2006.01.016
  104. C. Cruz; S. Mcmahon; F. Cruz. "ACTIVATION OF THE ERK SIGNALLING PATHWAY IN LUMBOSACRAL SPINAL CORD NEURONES OF SPINAL INJURED RATS BY BLADDER REFLEX ACTIVITY CONTRIBUTES TO DETRUSOR OVERACTIVITY". European Urology Supplements 5 2 (2006): 225-225. http://dx.doi.org/10.1016/s1569-9056(06)60816-6.
    10.1016/s1569-9056(06)60816-6
  105. Célia D. Cruz; António Avelino; Stephen B. McMahon; Francisco Cruz. "Increased spinal cord phosphorylation of extracellular signal-regulated kinases mediates micturition overactivity in rats with chronic bladder inflammation". European Journal of Neuroscience 21 3 (2005): 773-781. http://dx.doi.org/10.1111/j.1460-9568.2005.03893.x.
    10.1111/j.1460-9568.2005.03893.x
  106. Célia D. Cruz; Fani L. Neto; José Castro-Lopes; Stephen B. McMahon; Francisco Cruz. "Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats". Pain 116 3 (2005): 411-419. http://dx.doi.org/10.1016/j.pain.2005.05.031.
    10.1016/j.pain.2005.05.031
  107. Ferreira JG; Cruz C; Vinson GP; Pignatelli D. "ACTH modulates ERK phosphorylation in the adrenal gland in a time-dependent manner.". (2004): http://europepmc.org/abstract/med/15666809.
    10.1081/ERC-200043952
  108. A Avelino; C Cruz; I Nagy; F Cruz; Avelino, A.; Cruz, C.; Nagy, I.; Cruz, F.. "Vanilloid receptor 1 expression in the rat urinary tract". Neuroscience 109 4 (2002): 787-798. http://dx.doi.org/10.1016/s0306-4522(01)00496-1.
    10.1016/s0306-4522(01)00496-1
  109. Avelino, A.; Cruz, C.; Cruz, F.; António Avelino; Célia Cruz; Francisco Cruz. "Nerve growth factor regulates galanin and c-jun overexpression occurring in dorsal root ganglion cells after intravesical resiniferatoxin application". Brain Research 951 2 (2002): 264-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037019866&partnerID=MN8TOARS.
    10.1016/S0006-8993(02)03171-2
Capítulo de livro
  1. Ferreira, Ana Isabel; Fernandes, Sara; Chambel, Sílvia Sousa; Silva, Nuno; Cruz, Célia. "Traumatic spinal cord injury as a model for central neuropathic pain". In Translational Research Methods for Neuropathic Pain, editado por Springer. 2023.
    No prelo
  2. Cruz, Célia. "Mecanismos neurobiológicos da dor neuropática periférica". In Terapêuticas Tópicas no Tratamento da Dor Neuropática Periférica Localizada. Tópicos em Destaque na Dor Neuropática Periférica, editado por Mesquita, Graça. Portugal: Permanyer, 2021.
    Publicado
  3. Cruz, Célia; Avelino, Antonio. "Urinary bladder #1. Animal models of cystitis". In Channel Targets for Drugs and Toxins, editado por Humana Press, Springer Science. Humana Press, Springer Science, 2012.
  4. Cruz, Célia; Antunes-Lopes, Tiago; Silva, Carlos; Cruz, Francisco; Duarte, Clia; Antunes, Tiago; Cruz, Francisco. "Biomarkers in the overactive bladder syndrome". In Urinary Incontinence, editado por InTech publishers. InTech publishers, 2012.
    Publicado • 10.5772/35420
Poster em conferência
  1. Rodrigues, Adriana Raquel; Salazar, Maria; Rocha-Rodrigues, Sílvia; Gonçalves, Inês; Cruz, Célia; Almeida, H; Magalhães, J; Gouveia, Alexandra. "Alpha-MSH enhances transdifferentiation of white into brown-like adipocytes in mice". Trabalho apresentado em EMBO Workshop - Brown adipose tissue, 2017.
Resumo em conferência
  1. Oliveira, R; Coelho, A; Cruz, F; Cruz, C. "INTRATHECAL ONABOTULINUMTOXINA IMPROVES BLADDER FUNCTION AFTER SPINAL CORD INJURY AND EFFICIENTLY SUPRESSES NEUROGENIC DETRUSOR OVERACTIVITY". 2015.
  2. Charrua, A; Cruz, C; Boudes, M; De Ridder, D; Cruz, F. "TRPV1 AND TRPV4 ANTAGONISTS HAVE A SYNERGISTIC EFFECT DURING CYSTITIS". 2012.
  3. Antunes Lopes, T; Pinto, R; Barros, S; Botelho, F; Cruz, C; Cruz, F; Silva, C. "Can Urinary Neurotrophins Be Used to Monitor OAB Symptoms?". 2012.
  4. Cruz, F; Charrua, A; Frias, B; Avelino, A; Cruz, CD. "NGF-INDUCE DETRUSOR OVERACTIVITY IS TRPV1 DEPENDENT". 2010.
    10.1016/s1569-9056(10)60123-6
  5. Silva, A; Cruz, CD; Charrua, A; Pinto, R; Avelino, A; Silva, C; Dinis, P; Cruz, F. "GRC 6211, a new oral TRPV1 antagonist, decreases neurogenic detrusor overactivity in a rat model of spinal cord transection". 2008.
  6. Cruz, CD; Pinto, R; Silva, A; Allen, S; Dawbarn, D; McMahon, S; Cruz, F. "Increased bladder reflex activity induced by cystitis is reduced after neutralization of Brain Derived Nerve Factor (BDNF). An experimental study in the rat". 2008.
  7. Cruz, CD; Ferreira, D; McMahon, SB; Cruz, F. "Phosphorylation of extracellular signal regulated kinases (ERK) in the spinal cord depends on vanilloid-insensitive primary afferents as shown by intravesical instillation of resiniferatoxin". 2005.
  8. Cruz, F; Cruz, C; Charrua, A; Avelino, A; McMahon, SB. "Spinal cord phosphorylation of extracellular signal-regulated kinases (ERKs) is induced by sensory input conveyed in capsaicin-resistant bladder afferents and contributes to pain and bladder reflex overactivity in a chronic cystitis rat model". 2004.

Outros

Outra produção
  1. Animal Models of Cystitis. Methods in Pharmacology and Toxicology. 2012. Cruz, Célia.
    10.1007/978-1-62703-077-9_20
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023 What is being done in the bench? UROwebinar in collaboration with ESFFU
2023 How does Spinal Cord Injury induce immune dysfunction and how does it affect the bladder? 10th meeting of the ICI-RS
(Bristol, Reino Unido)
2023 NGF una “vieja” molécula con nuevas expectativas XIX Congreso da Sociedad Española del Dolor
(Madrid, Espanha)
2022 Conducting animal experiments Curso de Experimentação Animal
FMUP (Porto, Portugal)
2022 The role of serotonin-expressing urethral cells in normal micturition and LUTD INUS Annual Congress
(Innsbruck, Áustria)
2022 Is there a role of the urethra in the SCI-induced LUTD? INUS Annual Congress
(Innsbruck, Áustria)
2021/10 New trends: aplicações dos anti-NGF em dor VII Congresso APED2021
(Lisboa, Portugal)
2020 Animal models of multiple sclerosis and urinary dysfunction INUS Annual Congress
(Istambul, Turquia)
2020 Cellular signalling in neurogenic detrusor overactivity INUS Annual Congress
(Istambul, Turquia)
2019 Controlo do sistema periférico: o caso da bexiga Encontro sobre lesões vertebro medulares
Centro de Medicina de Reabilitação de Alcoitão (Lisboa, Portugal)
2019 Botulinum toxin A in the treatment of bladder dysfunction after spinal cord injury: beyond SNAP 25 cleavage. Meeting Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (SPN) (Lisboa, Portugal)
2019 Sprouting of bladder afferents after spinal cord injury: the role of growth inhibitory proteins at the lumbosacral spinal cord. Meeting Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (SPN) (Lisboa, Portugal)
2019 The success of onabotulinum toxin a in treating neurogenic bladder after spinal cord injury: Mechanisms beyond SNAP-25 cleavage. Annual Meeting Society for Neuroscience
Society for Neuroscience (SfN) (Chicago, Estados Unidos)
2018/08 Aging associated underactive bladder envolves a decrease in urethral serotonin released by 5HT-expressing cells. An experimental study in the rat. Annual Meeting of the International Continence Society
International Continence Society (ICS) (Filadélfia, Estados Unidos)
2018 Beyond animal urodynamics: What is the bladder tissue telling us? 6th International Neuro-Urology Meeting
International Neuro-Urology Society (INUS) (Zurique, Portugal)
2018 Prevention of neurogenic detrusor overactivity following spinal cord injury: Effects of early administration of resiniferatoxin and botulinum toxin A. Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Copenhaga, Dinamarca)
2018 Bladder Dysfunction treatment in an animal model of multiple sclerosis Annual Meeting of the International Continence Society
International Continence Society (ICS) (Filadélfia, Estados Unidos)
2018 Changes in Expression of Growth Inhibitory Proteins at the Lumbosacral Spinal Cord are Associated with Sprouting of Sensory Afferents after Thoracic Spinal Cord Injury Annual Meeting of the International Continence Society
International Continence Society (ICS) (Filadélfia, Estados Unidos)
2018 Urethral serotonin stimulates an urethrovesical reflex Annual Meeting of the International Continence Society
International Continence Society (ICS) (Filadélfia, Estados Unidos)
2017 Beyond animal urodynamics: What is the bladder tissue telling us? 5th International Neuro-Urology Meeting
International Neuro-Urology Society (INUS) (Zurique, Suiça)
2017 Disfunção da bexiga após lesões medulares: o que sabemos e o que queremos saber? Conferências Santa Casa da Misericória de Lisboa
Santa Casa da Misericória de Lisboa (Lisboa, Suiça)
2017 Expression and Function of Serotonin Paraneuronal Cells in the Urethral Epithelium of Human and Rodents. Annual Meeting of the American Urological Association
American Urological Association (AUA) (Boston, Estados Unidos)
2017 Distribution and Function of Cells Expressing Serotonin in the Lower Urinary Tract of Normal and Inflamed Rats Annual Meeting of the International Continence Society
International Continence Society (ICS) (Florença, Itália)
2017 Serotonin paraneuronal cells in the urethral epithelium of human and rodents: expression and function. Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Londres, Reino Unido)
2017 Development of neurogenic detrusor overactivity is prevented by early bladder afferent desensitization in spinal cord injured rats Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Londres, Reino Unido)
2016 Neurotrophins in spinal cord injury-induced neurogenic detrusor overactivity XIV Congresso SINUG
(Porto, Portugal)
2016 Impairment of sensory fibres by onabotulinumtoxinA improves neurogenic detrusor overactivity following spinal cord injury Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Munique, Alemanha)
2015 Is BDNF important for bladder dysfunction following spinal cord injury? First Spinal Cord Injury Symposium
(Alcoitão, Portugal)
2015 BDNF prevents the appearance of neurogenic detrusor overactivity (NDO) following spinal cord injury Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Madrid, Espanha)
2015 Intrathecal OnabotulinumtoxinA improves bladder function after spinal cord injury and efficiently supresses neurogenic detrusor overactivity. Annual Meeting of the International Continence Society
International Continence Society (ICS) (Montreal, Canadá)
2014 Can intrathecal botulinum toxin delivery be used to relieve severe bladder pain? Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Estocolmo, Suécia)
2014 Urinary neurotrophins and Qmax variation may predict de novo urgency in SUI patients after a midurethral sling (MUS) surgery Annual Meeting of the American Urological Association
American Urological Association (AUA) (Orlando, Florida, Portugal)
2013 Out of the box: neurotrophins in bladder function Dept. of Urology and Andrology, Paracelsus Medical University and Salzburg General Hospital; SCITReCS - Spinal Cord Injury and Tissue Regeneration Centre
(Salzburgo, Áustria)
2013 Urinary biomarkers for OAB: are we there yet? Dept. of Urology and Andrology, Paracelsus Medical University and Salzburg General Hospital; SCITReCS - Spinal Cord Injury and Tissue Regeneration Centre
(Salzburgo, Áustria)
2013 Molecular mechanisms of neurogenic detrusor overactivity (NDO): the case of Brain Derived Neurotrophic Factor (BDNF). Annual Meeting of the Swiss Continence Foundation
(Zurique, Suiça)
2013 Role of NGF in bladder inflammation-induced pain behavior and TRPV1 traffic Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Milão, Itália)
2013 Effect of intrathecal botulinum toxin type A in pain associated with chemical-induced cystitis Annual Meeting of the International Continence Society
International Continence Society (ICS) (Barcelona, Portugal)
2013 Role of Brain Derived Neurotrophic Factor (BDNF) in neurogenic detrusor overactivity (NDO) Annual Meeting of the International Continence Society
International Continence Society (ICS) (Barcelona, Espanha)
2012 Neurotrophins in bladder function Frontiers in Urology meeting
(Madrid, Espanha)
2012 Neurotrophins as urinary biomarkers: are we there yet? Congresso Anual da International Continence Society
International Continence Society (ICS) (Pequim, China)
2012 TRPV1 and TRPV4 expression in bladder neurons during normal condition and during cystitis Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Paris, França)
2012 TRPV1 and TRPV4 antagonists have synergistic effect for treating bladder overactivity in rats. Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Paris, França)
2012 High urinary levels of nerve growth factor and brain-derived neurotrophic factor in women with overactive bladder syndrome normalize after lifestyle intervention and antimuscarinic therapy Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Paris, França)
2012 Modulation of spinal BDNF levels by TrkB-Ig2 reduces detrusor overactivity in rats with chronic spinal cord injury Annual Meeting Society for Neuroscience
Society for Neuroscience (SfN) (New Orleans, Estados Unidos)
2012 Urinary neurotrophic factors in bladder pain syndrome/interstitial cystitis Annual Meeting of the American Urological Association
American Urological Association (AUA) (Atlanta, Estados Unidos)
2011/06 Neurotrophins: NGF and BDNF in bladder function Urinary incontinence – from basic science to clinical practice/ A Joint Symposium organized by INComb, TRUST and SEA with support from the European Association for Urology
(Estocolmo, Suécia)
2011 TRPV1 is essential for NGF-induced bladder overactivity and pain 36th Annual Meeting of the International Urogynecological Association
International Urogynecological Association (Lisboa, Portugal)
2011 Brain-Derived Neurotropic Factor: A New Potential Biomarker of Overactive Bladder Syndrome Congress of the Société Internationale d'Urologie
Société Internationale d'Urologie (SIU) (Berlim, Alemanha)
2011 Urinary levels of Brain Derived Neurotrophic Factor (BDNF) in women with overactive bladder (OAB) syndrome correlate with the severity of symptoms. Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Viena, Áustria)
2011 Autonomic sympathetic nervous system activity is enhanced during chronic inflammation and contributes to bladder hyperactivity and pain Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Viena, Áustria)
2011 Spread of onabotulinum A after injection in the bladder wall. Experimental study in guinea-pig urinary bladder using the distribution of cleaved SNAP-25 Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Viena, Áustria)
2011 Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF) play complementary roles in bladder control Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Viena, Áustria)
2011 NGF-induced signalling in the bladder is modulated by caveolae Meeting Society for Urodynamics and Female Urology
Society for Urodynamics and Female Urology (SUFU) (Washington, Estados Unidos)
2011 Nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) mediate visceral pain and bladder hyperactivity in chronic cystitis Annual Meeting Society for Neuroscience
Society for Neuroscience (SfN) (Washington, Estados Unidos)
2011 TRPV1 mediates NGF-induced visceral pain and inflammatory bladder hyperactivity Annual Meeting Society for Neuroscience
Society for Neuroscience (SfN) (Washington, Estados Unidos)
2011 Factor de Crescimento Derivado do Cérebro: um potencial biomarcador do Síndrome de Bexiga Hiperactiva Meeting Associação Portuguesa Urologia
Associação Portuguesa Urologia (Lisboa, Portugal)
2011 Efeito da dose e do volume na difusão de Onabotulinum A injectada na bexiga do Cobaio Meeting Associação Portuguesa Urologia
Associação Portuguesa Urologia (Lisboa, Portugal)
2011 Factor de crescimento Nervoso (NGF) e factor de Crescimento Derivado do Cérebro (BNDF) como potenciais mediadores no desenvolvimento de hiperactividade vesical. Meeting Associação Portuguesa Urologia
Associação Portuguesa Urologia (Lisboa, Portugal)
2011 Urinary neurotrophins – potential biomarkers of overactive bladder Annual Meeting of the American Urological Association
American Urological Association (AUA) (Washington, Estados Unidos)
2010 Correction of KCC2 expression at the spinal cord ameliorates pain behaviour in painful diabetic neuropathy: a role of microglia activation and oxidative stress World Congress on Pain - IASP
IASP (Montreal, Canadá)
2010 Neutrophin blockade reduces referred pain in an animal modelo f chronic cystitis World Congress on Pain - IASP
IASP (Montreal, Canadá)
2010 Bladder overactivity caused by chronic cystitis is decreased by neutrophin blockade World Congress on Pain - IASP
IASP (Montreal, Canadá)
2010 NGF-induced detrusor overactivity is TRPV1-dependent World Congress on Pain - IASP
IASP (Montreal, Canadá)
2010 Prolonged adrenergic stimulation induces detrusor overactivity and increases bladder noxious input. Experimental study in the rat. Annual Meeting Society for Neuroscience
Society for Neuroscience (SfN) (San Diego, Califórnia, Estados Unidos)
2010 Action of botulinum toxin type A on parasympathetic ganglia of the guinea-pig urinary bladder Meeting of the Federation of European Neuroscience Societies
Federation of European Neuroscience Societies (FENS) (Amesterdão, Países Baixos)
2010 Downregulation of KCC2 is induced by microglia hyperactivity and oxidative stress in a painful diabetic neuropathy model Meeting of the Federation of European Neuroscience Societies
Federation of European Neuroscience Societies (FENS) (Amesterdão, Países Baixos)
2010 Botulinum toxin type A acts on bladder intramural parasympathetic ganglia. An experimental study in the guinea-pig Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Barcelona, Espanha)
2010 NGF-induced detrusor overactivity is TRPV1 dependent Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Barcelona, Espanha)
2009 Nerve growth factor-evoked regulation of the endovanilloid system 29th European Winter Conference on Brain Research
(Les Arcs, França)
2009 BDNF sequestration at the spinal cord level reduces pain and bladder overactivity in rats with chronic cystitis Annual Meeting of Society for Neuroscience
Society for Neuroscience (SfN) (Chicago, Estados Unidos)
2009 Chemical neuromodulation in patients with bladder pain syndrome (BPS) EFIC Congress of the European Federation of IASP® Chapters
European Federation of IASP® Chapters (Lisboa, Portugal)
2009 Distribution and neurochemistry of botulinum toxin type A receptor in the urinary bladder EFIC Congress of the European Federation of IASP® Chapters
European Federation of IASP® Chapters (Lisboa, Portugal)
2009 Intrathecal BDNF sequestration reduces referred pain and bladder overactivity in an animal model of chronic bladder inflammation EFIC Congress of the European Federation of IASP® Chapters
European Federation of IASP® Chapters (Lisboa, Portugal)
2009 Intrathecal blockeade of NGF decreases referred pain a rat model of chronic bladder inflammation EFIC Congress of the European Federation of IASP® Chapters
European Federation of IASP® Chapters (Lisboa, Portugal)
2009 Spinal microglia and BDNF inhibition prevents mechanical hyperalgesia and dorsal horn neuronal hyperactivity during diabetic neuropathy EFIC Congress of the European Federation of IASP® Chapters
European Federation of IASP® Chapters (Lisboa, Portugal)
2008 Reducing bladder hyperactivity caused by spinal cord injury: targeting TRPV1 and beyond 28th European Winter Conference on Brain Research
(Les Arcs, França)
2008 GRC 6211, a new oral TRPV1 antagonist, decreases the frequency of bladder reflex contractions and noxious input in rats with acute or chronic cystitis Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Milão, Itália)
2008 The oral TRPV1 antagonist GRC 6211 reduces bladder overactivity and noxious bladder input in cystitis Annual Meeting of the American Urological Association
American Urological Association (AUA) (Orlando, Florida, Estados Unidos)
2008 BDNF is important for bladder hyperactivity and pain in a rat model of chronic bladder inflammation Annual Meeting of Society for Neuroscience
Society for Neuroscience (SfN) (Washington, Estados Unidos)
2008 Increased bladder reflex activity induced by cystitis is reduced after neutralization of brain derived nerve factor (BDNF). An experimental study in the rat. Annual Meeting of the International Continence Society
International Continence Society (ICS) (Cairo, Egipto)
2008 GRC 6211, a new oral trpv1 antagonist, decreases neurogenic detrusor overactivity in a rat model of spinal cord transection Annual Meeting of the International Continence Society
International Continence Society (ICS) (Cairo, Egipto)
2007 Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats
Instituto de Histologia e Embriologia Abel Salazar da Faculdade de Medicina da Universidade do Porto (Porto, Portugal)
2007 A administração intratecal de resinieferatoxina (RTX) reduz a hiperactividade vesical neurogénica. Estudo experimental no rato. Congresso da Associação Portuguesa de Urologia
Associação Portuguesa de Urologia (Vilamoura, Portugal)
2007 The TRPV1 receptor: a new target for treating visceral pain and hyperactivity 10º Congresso da Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Ofir, Portugal)
2007 Effect of GRC 6211, a new oral TRPV1 antagonist, in the frequency of bladder reflex activity and noxious input in rat models of acute and chronic cystitis Annual Meeting of Society for Neuroscience
Society for Neuroscience (SfN) (San Diego, Estados Unidos)
2006 Importance of the ERK-1/2 intracellular signalling cascade in visceral and joint pathology
Instituto de Biologia Molecular e Celular da Universidade do Porto (Porto, Portugal)
2006 Intrathecal administration of resiniferatoxin (RTX) abolishes bladder hyperactivity caused by chronic spinal cord transection Annual Meeting of Society for Neuroscience
Society for Neuroscience (SfN) (Atlanta, Estados Unidos)
2005/09 Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats
Instituto de Histologia e Embriologia Abel Salazar da Faculdade de Medicina da Universidade do Porto (Porto, Portugal)
2005 Increased spinal cord phosphorylation of extracellular signal-regulated kinases mediates micturition overactivity with chronic bladder inflammation
Instituto de Histologia e Embriologia Abel Salazar da Faculdade de Medicina da Universidade do Porto (Porto, Portugal)
2005 Phosphorylation of extracellular signal regulated kinases (ERK) in the spinal cord depends on vanilloid insensitive primary afferents as shown by intravesical instillation of resiniferatoxin FEBS Congress
FEBS
2005 ERK phosphorylation is involved in bladder overactivity associated with spinal cord injury Annual Meeting of Society for Neuroscience
Society for Neuroscience (SfN) (Washington, Estados Unidos)
2004/10 Neuronal signalling by ERKs: key elements in pain IBMC Advanced Course on Oxidative Stress and Cell Signalling
IBMC (Porto, Portugal)
2004/07 Intrathecal injection of PD98059, a specific inhibitor of extracellular signal-regulated kinases 1/2 (ERKs 1/2), attenuates allodynia in monoarthritic rats Meeting of the Federation of European Neuroscience Societies
Federation of European Neuroscience Societies (FENS) (Lisboa, Portugal)
2004 Phosphorylation of extracellular signal-regulated kinases (ERKs) in the spinal cord is upregulated by chronic inflammation. XXXIX Reunião da Sociedade Portuguesa de Microscopia Electrónica e Biologia Celular
(Aveiro, Portugal)
2004 Iodoresiniferatoxin (IRTX) applied topically to the rat bladder acts as potent TRPV1 agonist Annual Meeting of Society for Neuroscience
Society for Neuroscience (SfN) (San Diego, Estados Unidos)
2004 Extracellular signal-regulated kinases 1 and 2 (ERKs) are upregulated in the spinal cord of chronic inflamed animals and regulate visceral reflex activity and pain Annual Meeting of Society for Neuroscience
Society for Neuroscience (SfN) (San Diego, Estados Unidos)
2004 Spinal cord phosphorylation of extracellular signal-regulated kinases (ERKs) is induced by sensory input conveyed in capsaicin-resistant bladder afferents and contributes to pain and bladder reflex overactivity in a chronic cystitis rat model Annual Meeting of the International Continence Society
International Continence Society (ICS) (Paris, França)
2004 Extracellular signal-regulated kinases 1 and 2 (ERKs 1/2) are involved in micturition control at the spinal cord level in cyclophosphamide (CYP)-inflamed animals. Meeting of the Federation of European Neuroscience Societies
Federation of European Neuroscience Societies (FENS) (Lisboa, Portugal)
2003 Modulation of the activity of ERKs 1 and 2 by chronic inflamamtory conditions Encontro Anual dos Programas Gulbenkian de Doutoramento em Biologia e Medicina e Biomedicina
(Curia, Portugal)
2003 Extracellular signal-regulated kinases 1 and 2 (ERKs 1/2) activity in the spinal cord under chronic bladder inflammation 8º Congresso da Sociedade Portuguesa de Neurociências
Sociedade Portuguesa de Neurociências (Curia, Portugal)
2003 ERK phosphorylation is mediated by ACTH in the adrenal gland of the rat FEBS Special Meeting on Signal Transduction
(Bruxelas, Bélgica)
2002 ERKs 1, 2: key players in a painful game? Encontro Anual dos Programas Gulbenkian de Doutoramento em Biologia e Medicina e Biomedicina
(Curia, Portugal)
2002 ERK phosphorylation and c-Fos expression induced by bladder noxious stimuli are dependent upon different subtypes of primary afferent fibres Annual Meeting of Society for Neuroscience
Society for Neuroscience (SfN) (Orlando, Estados Unidos)
2001 Bladder sensory fibres immunoreactive to the vanilloid receptor type 1 (VR1): relationship to neuropeptides and IB4 binding sites. A confocal laser study Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Génova, Itália)
2001 Chronic bladder outlet obstruction injures bladder sensory neurons, as shown by galanin over-expression. An experimental study in the rat. Annual Meeting of the European Association of Urology
European Association of Urology (EAU) (Génova, Itália)
2000 Sensory fibres immunoreactive to the vanilloid receptor protein: distribution in the rat urinary bladder Annual Meeting of the International Continence Society
International Continence Society (ICS) (Tampere, Finlândia)
2000 Distribution of the vanilloid receptor (VR-1) immunoreactive fibres in the rat urinary tract Annual Meeting of Society for Neuroscience
Society for Neuroscience (Sfn) (New Orleans, Estados Unidos)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - Atual How important is the urethra? Impact of spinal cord injury on the urethra and lower urinary tract function.
Orientador
 Programa doutoral em Neurociências (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2018 - Atual Urinary dysfunction after spinal cord injury: resolving neuronal mechanisms behind neurogenic detrusor overactivity and detrusor-sphincter-dyssinergia
Orientador
 Neurociências (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2023 - 2023/06 Involvement of microglia in chronic neuropathic pain associated with spinal cord injury - A systematic review
Orientador
 Master degree in Medicine (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2023 - 2023 Molecular mechanism operating in animal models of neurogenic detrusor overactivity: a systematic review focusing on bladder dysfunction of neurogenic origin.
Orientador
 Medicine (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2022 - 2022 Involvement of NGF in chronic neuropathic pain. A systematic review.
Orientador
 Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2021 - 2022 Is Nerve Growth Factor (NGF) involved in pain after spinal cord injury? A systematic review of literature.
Orientador
Universidade do Porto Faculdade de Medicina, Portugal
2021 - 2022 The role of astrocytic FOXO1 in the mouse brain and its modulation of behavior.
Orientador
 Mestrado em Neurobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2020 - 2021 The role of the astrocytic mGluR5 in behavior dependent on the ventral hippocampus and the prefrontal corxtex.
Coorientador
 Mestrado em Neurobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2020 - 2020 Changes in urethral function following spinal cord injury
Orientador
 Neurobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2020 - 2020 Determining the consequences of neuronal hyperactivity on cell fitness in vivo and in vitro in Neurodegenerative disorders.
Orientador
 Neurobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2019 - 2020 Changes in urethral function following spinal cord injury
Orientador
 Neurobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2019 Management of neurogenic detrusor overactivity caused by spinal cord injury. The case of botulinum toxin and resiniferatoxin
Orientador
 Neurociências (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2019 Management of neurogenic detrusor overactivity caused by spinal cord injury. The case of botulinum toxin and resiniferatoxin
Orientador
 Programa doutoral em Neurociências (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2018 From poison to clinical application: Is Botulinum Toxin A as treatment option for pain arising after spinal cord injury?
Orientador
 Neurobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2018 From poison to clinical application: Is botulinum toxin A a treatment for pain arising after spinal cord injury?
Orientador
 Neurobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2017 Is TRPV l involved in pain and bladder dysfunction associated with multiple sclerosis? An experimental study in the rat
Orientador
 Neurobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2017 Trabalhos a título voluntário
Orientador
 Medicina (Iniciação científica)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2017 Is TRPV1 involved in pain and bladder dysfunction associated with multiple sclerosis? An experimental study in the rat
Orientador
 Neurobiologia (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2016 Management of Neurogenic Detrusor Overactivity Caused by Spinal Cord Injury - The Case of Botulinum Toxin and Resiniferatoxin
Orientador
 Neurociências (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2015 - 2016 Mechanisms of pain and bladder dysfunction in an experimental model of multiple sclerosis
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2014 - 2014 Sympathetic nervous system and visceral pain: the case of the bladder pain syndrome
Orientador
 Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2014 Molecular mechanisms involved in neurogenic detrusor overactivity
Orientador
 Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2014 Sympathetic nervous system and visceral pain: the case of the bladder pain syndrome
Orientador
 Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2014 Molecular mechanisms involved in neurogenic detrusor overactivity
Orientador
 Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2009 - 2013 The importance of the neurotrophins NGF and BDNF in bladder dysfunction
Orientador
 Neurociências (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2011 Importance of neurotrophins in the overactive bladder. Experimental study in the rat
Orientador
 Neurociências (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2009 Ativação das vias de sinalização intracelular das ERKs 1 e 2 e da p38 em carcinomas de células de transição da bexiga
Coorientador
 Medicina e Oncologia Molecular (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2009 Contribution of NGF and BDNF for referred pain and blader overactivity in an animal model of chronic bladder inflammation
Orientador
 Bioquímica (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2006 - 2007 Redução da hiperreflexia vesical em ratos espinalizados através da modulação do receptor TRPV1
Orientador
 Biologia (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2003 - 2004 Papel e regulação da actividade das fosfoERKs na função vesical em diferentes condições
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022 - Atual Encontro Nacional das Unidades de Dor 2022 (2022 - 2022) Associação Portuguesa Para o Estudo da Dor, Portugal
2021 - Atual Organização do Congresso APED 2021 (2020)
Congresso (Membro da Comissão Científica)
 Associação Portuguesa Para o Estudo da Dor, Portugal
2023 - 2023 Congresso APED 2023 (2023 - 2023)
Congresso (Presidente da Comissão Organizadora)
 Associação Portuguesa Para o Estudo da Dor, Portugal
2023 - 2023 VIII Congresso da Associação Portuguesa para o Estudo da Dor. Presidiu à comissão organizadora e científica (2023 - 2023) Associação Portuguesa Para o Estudo da Dor, Portugal
2022/06/09 - 2022/06/11 Organization of workshop "Translational research" no 9th International Neuro-Urology Meeting, Innsbruck Austria (2022/06/09)
Oficina (workshop) (Coorganizador)
2022 - 2022 Encontro Nacional das Unidades de Dor 2022 (2022) Associação Portuguesa Para o Estudo da Dor, Portugal
2020 - 2020 Organization of workshop "Translational impact of animal models of neurologic diseases with urological symptoms" no 8th International Neuro-Urology Meeting, Istanbul, Turquia. (2020 - 2020)
Oficina (workshop) (Membro da Comissão Organizadora)
 International Neuro-Urology Society (INUS), Suiça
2020 - 2020 Organização do Encontro Anual de Investigadores em Lesões Medulares (2020/07/01 - 2020/07/03)
Encontro (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Medicina, Portugal
2019 - 2019 Organização do curso “Translational Research” no 7th International Neuro-Urology Meeting, Zurich, Switzerland. (2019 - 2019)
Oficina (workshop) (Membro da Comissão Organizadora)
 International Neuro-Urology Society (INUS), Suiça
2018 - 2018 Organização do curso “Translational Research” no 6th International Neuro-Urology Meeting, Zurich, Switzerland. (2018 - 2018)
Oficina (workshop) (Membro da Comissão Organizadora)
 International Neuro-Urology Society (INUS), Suiça
2017 - 2017 Organização do curso “Translational Research” no 5th International Neuro-Urology Meeting, Zurich, Switzerland. (2017 - 2017)
Oficina (workshop) (Membro da Comissão Organizadora)
 International Neuro-Urology Society (INUS), Suiça
2012 - 2015 Responsável pela organização dos Seminários FMUP, com frequência semanal. (2012 - 2015)
Seminário (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2014 Organização do 4º Encontro de Alunos de Doutoramento da Faculdade de Medicina do Porto. (2014 - 2014)
Encontro (Membro da Comissão Organizadora)
 Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2014 Revisão dos sumários de trabalhos submetidos para apresentação no 4º Forum da Federation of European Neuroscience Societies. (2004)
Congresso (Outra)
 Federation of European Neuroscience Societies, Bélgica
2013 - 2013 Organização do curso “Regulation of bladder function: new insights into participants and mechanisms”, na 42ª Reunião da International Continence Society. Esta reunião teve lugar em Barcelona, Espanha. (2013 - 2013)
Congresso (Membro da Comissão Organizadora)
 International Continence Society (ICS), Reino Unido
2012 - 2012 Organização do curso “Regulation of bladder function: new insights into participants and mechanisms" na 41ª Reunião da International Continence Society. Esta reunião teve lugar em Pequim, China. (2012)
Encontro (Membro da Comissão Organizadora)
 International Continence Society (ICS), Reino Unido

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/12/12 The impact of Spinal Cord Injury in the spleen innervating sympathetic postganglionic neurons
Arguente principal
 Maria Moreira Teixeira Alves de Moura (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
2023/11/17 Prevention of neurogenic detrusor overactivity after spinal cord injury. Effects of early combined treatment with resineferatoxin and darifenacin.
Orientador
 Inês Filipa Breia Lisboa (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2023/11/02 Combined baclofen with pregabalin administration as a potential therapy for spinal cord injury
Arguente principal
 Marta Raquel Lima Ferreira (Mestrado)
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2023/07/23 Mesenchymal Stem Cell Secretome Loaded StarPEG-GAG Hydrogels as a New Route to Induce Spinal Cord Injury Regeneration
Arguente
 Deolinda Isabel Fernandes da Silva (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/07/05 DEVELOPMENTAL VENOUS ANOMALIES, CEREBRAL CAVERNOUS MALFORMATIONS AND BEYOND: NEUROIMAGING INSIGHT INTO PEDIATRIC CEREBROVENOUS VASCULAR MALFORMATIONS
Vogal
 Ana Filipa Geraldo da Silva Couceiro (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2023/06/19 The role of microglia in chronic pain pathways associated with spinal cord injury - A systematic review
Orientador
 David Ferreira Ramos (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2023/06/01 Molecular Mechanism Operating in Animal Models of Neurogenic Detrusor Overactivity: A Systematic Review Focusing on Bladder Dysfunction of Neurogenic Origin
Orientador
 Diogo Emanuel Sampaio Nascimento (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2022/05/11 Involvement of NGF in chronic neuropathic pain. A systematic review.
Orientador
 Catarina Isabel Baião Pereira dos Reis (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2021/05/21 Effects of Dexmedetomidine in non-operating room anesthesia in adults: a systematic review with meta-analysis
Presidente do júri
 Francisca Jerónimo Martins Guimarães Fonseca (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2021 Molecular Therapies to Repair the Injured Spinal Cord
Arguente
 Rui Augusto Ribeiro Lima (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 The secretome of Mesenchymal Stem Cells as a cell-free based therapy for Spinal Cord Injury
Arguente
 Rita Catarina Assunção Ribeiro Silva (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 THE EXTRACELLULAR ‘MEMORIES’ IN PARKINSON’S DISEASE
Arguente
 Ana Maria Salgueiro Freitas (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2021 Efeitos da Dexmedetomidina na anestesia fora do bloco no adulto: uma revisão sistemática com meta-análise
Presidente do júri
 Francisca Jerónimo Martins Guimarães Fonseca (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2020 “O Papel dos Fatores Neurotróficos nas Disfunções Miccionais: Implicações Fisiológicas e Clínicas”
Orientador
 Tiago Vieira da Conceição Antunes Lopes (Doutoramento)
2020 Determination of the appropriate dosage of Adipose tissue-derived Stem Cell secretome for Spinal Cord Injury Regenerative Medicine Approaches
Arguente principal
 Tiago André Moreira Gomes (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020 Treatment of Idiopathic Overactive Bladder with Botulinum Toxin: Real life Results and Patients’ Expectations/ Tratamento da Bexiga Hiperativa Idiopática com Toxina Botulínica: Resultados da Prática Clínica e Expectativas das Pacientes
Presidente do júri
 Maria Inês Portugal Rodrigues (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2019 Management of Neurogenic Detrusor Overactivity caused by spinal cord injury: the case of botulinum toxin and resiniferatoxin
Orientador
 Raquel Leal Monteiro Mano de Oliveira (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2018 From poison to clinical application: Is botulinum toxin A a treatment for pain arising after spinal cord injury?
Orientador
 Ana Rita Alves da Silva (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2018 Assessment of the therapeutic effects of adipose mesenchyma stem cells secretome on a mouse spinal cord injury model
Arguente
 Jorge Miguel Cibrão Ribeiro (Mestrado)
Universidade do Minho, Portugal
2017 Is TRPV1 involved in pain and bladder dysfunction associated with multiple sclerosis? An experimental study in the rat
Orientador
 Helena Isabel Alvites Cavaleiro (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2013 The importance of the neurotrophins NGF and BDNF in bladder dysfunction. An experimental study in the rat.
Orientador
 Bárbara Filipa Frias Garrido (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2013 Mechanisms of action of botulinum toxin in the treatment of overactive bladder
Arguente
 Ana Cristina Martins Pinto Coelho (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2010 Efeito da aplicação de um estímulo nóxico e do tratamento crónico com Amitriptilina num modelo de dor crónica neuropática - expressão de pERKs em núcleos encefálicos do Tronco Cerebral
Arguente
 Gisela Patrícia da Silva Borges (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2010 Role of glial cells in neuropathic pain: potential therapeutic advantages with the use of opioids
Arguente
 Mariana Sofia Silva Afonso (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2021/10/15 - 2021/10/16 VII Congresso APED2021
2017 - 2017 32º Congresso Anual da European Association of Urology Londres, Reino Unido
2013 - 2013 28º Congresso Anual da European Association of Urology Milão, Itália
2012 - 2012 27º Congresso Anual da European Association of Urology Paris, França

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020 - Atual Frontiers in Molecular Neuroscience Archive - Molecular Signalling and Pathways
2008 - Atual Neuroscience Letters (0304-3940) Elsevier
2008 - Atual Clinical Journal of Pain (0749-8047) Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
2008 - Atual Pancreas (0885-3177) Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
2008 - Atual European Journal of Pain (1532-2149) Wiley (John Wiley & Sons)
2008 - Atual Molecular Pain (1744-8069) SAGE Publications
2008 - Atual Neurourology and Urodynamics (1520-6777) Wiley (John Wiley & Sons)
2008 - Atual BJU International (1464-410X) Wiley (Blackwell Publishing)
2008 - Atual European Urology (1421-993X) Elsevier
2008 - Atual Brain Research (0006-8993) Elsevier
2008 - Atual Pharmacologival Research
2008 - Atual Pain (1872-6623) Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
2008 - Atual Canadian Journal of Physiology and Pharmacology (1205-7541) Canadian Science Publishing
2008 - Atual Experimental Physiology (0958-0670) Wiley (The Physiological Society)
2008 - Atual Diabetes Obesity and Metabolism (1463-1326) Wiley (Blackwell Publishing)
2008 - Atual Naunyn-Schmiedeberg's Archives of Pharmacology
2008 - Atual Autonomic Neuroscience (1566-0702) Elsevier
2008 - Atual Journal of Neuroscience (1529-2401) Society for Neuroscience
2008 - Atual Nature Reviews Urology (1759-4820) Springer Science and Business Media LLC
2008 - Atual The Journal of Urology (1527-3792) Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
2008 - Atual Neuroreport (0959-4965) Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
2008 - Atual Life Sciences (0024-3205) Elsevier
2008 - Atual PLoS ONE (1932-6203) Public Library of Science
2008 - Atual Neurorehabilitation and Neural Repair (1552-6844) SAGE Publications
2008 - Atual Neuromodulation Technology at the Neural Interface (1525-1403) Wiley (Blackwell Publishing)
2008 - Atual Biomedical Research Allied Academies
2008 - Atual European Urology Focus (2405-4569) Elsevier
2008 - Atual American Journal of Physiology
2008 - Atual BMC Neuroscience (1471-2202) Springer (Biomed Central Ltd.)
2008 - Atual Aging Cell (1474-9728) Wiley (Blackwell Publishing)
2008 - Atual British Journal of Medicine and Medical Research (2231-0614) Sciencedomain International
2008 - Atual European Journal of Obstetrics & Gynecology and Reproductive Biology (0301-2115) Elsevier
2008 - Atual Nephron (1423-0186) S. Karger AG
2008 - Atual Neurobiology of Disease (1095-953X) Elsevier
2008 - Atual Bone and Tissue Regeneration Insights (1179-061X) "Libertas Academica, Ltd."
2008 - Atual British Journal of Pharmacology (1476-5381) Wiley (Blackwell Publishing)
2008 - Atual European Journal of Neurology (1468-1331) Wiley (Blackwell Publishing)
2008 - Atual Journal of Visualized Experiments (1940-087X) MyJoVE Corporation
2008 - Atual eNeuro (2373-2822) Society for Neuroscience
2008 - Atual Experimental Dermatology (1600-0625) Wiley (Blackwell Publishing)
2008 - Atual International Journal of Molecular Sciences (1422-0067) MDPI AG
2008 - Atual Gene Therapy (0969-7128) Springer Science and Business Media LLC
2008 - Atual Journal of Clinical Investigation (1558-8238) American Society for Clinical Investigation
2008 - Atual Toxins (2072-6651) MDPI AG
2008 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2008 - Atual Journal of Cellular and Molecular Medicine (1582-4934) Wiley (Blackwell Publishing)
2015 - 2015 Cellular & Molecular Medicine Open access (2573-5365) Scitechnol Biosoft Pvt. Ltd (OMICS)
2011 - 2012 Pain Research and Treatment (2090-1550) Hindawi Limited
2011 - 2011 Current Neuropharmacology (1570-159X) Bentham Science

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2019/10 - 2019/10 Convidada pelo National Science Center (NCN panel NZ5), Poland, avaliou o projecto Preludium-17.
2019/08 - 2019/08 Convidada pela Biotechnology and Biological Sciences Research Council of United Kingdom, avaliou o projeto BB/T004347/1 Universidade do Porto Faculdade de Medicina, Portugal
2019 - 2019 Avaliação do projeto BB/T004347/1- a convite do Biotechnology and Biological Sciences Research Council of United Kingdom, Biotechnology and Biological Sciences Research Council, Reino Unido
2019 - 2019 Avaliação do projecto Preludium-17, a convite do National Science Center (NCN panel NZ5), Poland. National Science Center Poland, Polónia
2017/06 - 2017/06 Convidada pela Reitoria da Universidade do Porto, avaliou uma candidatura às Ações Luso-Alemãs CRUP, Ação A-02/18 Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2017 Avaliação de uma candidatura às Ações Luso-Alemãs CRUP, Ação A-02/18, a convite da Reitoria da Universidade do Porto. Universidade do Porto, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021 - Atual Histologia I. Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2021 - Atual Histologia II. Embriologia. Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2015 - Atual Modelos Experimentais em Neurociências Neurobiologia (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2007 - Atual Abordagens metodológicas em neurociências Neurociências (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2007 - Atual Neurobiologia Funcional Neurociências (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2004 - Atual Director of Curso de Pós-Graduação em Medicina da Dor Medicina da Dor (Especialização pós-licenciatura) Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2021 Medicina regenerativa Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2021 Morfofisiologia do Aparelho Locomotor Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2021 Morfofisiologia do Sistema Nervoso Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2021 Morfofisiologia dos Sistemas Reprodutor e Endócrino Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2021 Morfofisiologia do Sistema Cardiovascular e do Sangue Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2021 Morfofisiologia dos Sistemas Respiratório e Urinário Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2021 Morfofisiologia Integrativa Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2021 Morfofisiologia do Aparelho Digestivo Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2007 - 2013 Histologia Básica e Embriologia (1º semestre) Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2007 - 2013 Histologia e Embriologia dos Órgãos e Sistemas (2º semestre) Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2010 Histologia e Embriologia Medicina Dentária (Mestrado integrado) Universidade do Porto Faculdade de Medicina Dentária, Portugal
2004 - 2007 Histologia e Embriologia Medicina (Licenciatura) Universidade do Porto Faculdade de Medicina, Portugal
2004 - 2006 Sinalização intracelular Medicina e Oncologia Molecular (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2003/03 - 2004 Histologia Ciências da Nutrição (Licenciatura) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2003 - 2004 Biologia Celular e Molecular Ciências da Nutrição (Licenciatura) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal

Membro de associação

Nome da associação Tipo de participação
2004 - Atual Society for Neuroscience
2004 - Atual European Association of Urology
2004 - Atual International Continence Society
2004 - Atual Associação Portuguesa para o Estudo da Dor
2004 - Atual International Association for the Study of Pain
2019/10/20 - 2022/10/29 Associação Portuguesa para o Estudo da Dor Vogal da Direcção
2019/10 - 2022/10 Associação Portuguesa para o Estudo da Dor Vogal da Direcção

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2022 - Atual Director of the Post-Graduation Course in Pain Medicine
Diretor
 Universidade do Porto Faculdade de Medicina, Portugal
2021 - Atual Membro da Comissão Científica do Programa Doutoral em Neurociências
Membro
2018/09/01 - 2025/09/01 Membro da Comissão Científica do Mestrado em Neurobiologia
Membro
 Universidade do Porto Faculdade de Medicina, Portugal
2023/10/20 - 2023/10/21 VII Congresso APED 2023
Coordenador
 Associação Portuguesa Para o Estudo da Dor, Portugal

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2023 - Atual Arguer of the jury of the master's exams of the graduate Maria Moreira Teixeira Alves de Moura in the Master's in Molecular Genetics of the School of Sciences of the University of Minho, having discussed the dissertation entitled "The impact of Spinal Cord Injury in the spleen-innervating sympathetic postganglionic neurons”. Universidade do Minho Escola de Ciências da Saúde, Portugal
2023 - Atual Arguer in jury of the master's exams of graduate Marta Raquel Lima Ferreirano Master in Biomedical Sciences from the Faculty of Medicine and Biomedical Sciences of the University of Algarve, having discussed the dissertation entitled " Combined baclofen with pregabalin administration as a potential therapy for spinal cord injury”. Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2023 - Atual Member of the jury for the doctoral exams of graduate Ana Filipa Geraldo da Silva Couceiro in the Doctoral Program in Neurosciences - Clinical Branch of the Faculty of Medicine of the University of Porto, having discussed the dissertation entitled "Developmental venous anomalies, cerebral cavernous malformations and beyond: neuroimaging insight into pediatric cerebrovenous vascular malformations.” Universidade do Porto Faculdade de Medicina, Portugal
2023 - Atual Main arguer, of the jury of Master Deolinda Isabel Fernandes da Silvano's doctoral examinations Doctoral Program in Health Sciences of the School of Medicine of the University of Minho, having discussed the dissertation entitled " Mesenchymal Stem Cell Secretome Loaded StarPEG-GAG Hydrogels as a New Route to Induce Spinal Cord Injury Regeneration.” Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 - Atual President of the jury for the master's exams of graduate Francisca Jerónimo Martins Guimarães Fonseca in the Integrated Master's Degree in Medicine at the Faculty of Medicine of the University of Porto, having discussed the dissertation entitled "Effects of Dexmedetomidine on anesthesia outside the block in adults: a systematic review with meta-analysis”. Universidade do Porto Faculdade de Medicina, Portugal
2021 - Atual Member of the jury for Master Ana Maria Salgueiro Freitas' doctoral exams within the scope of the Doctoral Program in Neurosciences, at the Faculty of Medicine of the University of Porto. His thesis was entitled "The extracellular “memories” in Parkinson’s disease” Universidade do Porto Faculdade de Medicina, Portugal
2021 - Atual Main opponent for Master Rui Augusto Ribeiro Lima's doctoral exams as part of the Doctoral Program in Health Sciences, at the School of Medicine of the University of Minho. His thesis was entitled "Molecular Therapies to Repair the Injured Spinal Cord”. Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020 - Atual Arguer of the Master's thesis in Health Sciences Doctoral in Health Sciences, from the University of Minho, by graduate Tiago André Moreira Gomes. The title of his thesis was “The secretome of Mesenchymal Stem Cells as a cell-free based therapy for Spinal Cord Injury” Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2020 - Atual Arguer, from the jury of the master's exams of graduate Inês Portugal-Rodrigues in the Integrated Master's Degree in Medicine at the Faculty of Medicine of the University of Porto, having discussed the dissertation entitled "Treatment of Idiopathic Overactive Bladder with Botulinum Toxin: Real-life Results and Patients' Expectations”.
2020 - Atual Arguer of the doctoral thesis presented within the scope of the Doctoral Program in Health Sciences, at the University of Minho, by master Rita Assunção Ribeiro da Silva. The title of his thesis was “Determination of the appropriate dosage of Adipose tissue-derived Stem Cell secretome for Spinal Cord Injury Regenerative Medicine Approaches” Universidade do Porto Faculdade de Medicina, Portugal
2020 - Atual Member of the jury for the doctoral exams of graduate Tiago Vieira da Conceição Antunes Lopes within the scope of the Doctoral Program in Medicine, at the Faculty of Medicine of the University of Porto. His thesis was entitled “The Role of Neurotrophic Factors in Voiding Dysfunctions: Physiological and Clinical Implications”. Universidade do Porto Faculdade de Medicina, Portugal
2020 - Atual Member of the jury for Master José Tiago Costa Pereira's doctoral exams within the scope of the Doctoral Program in Neurosciences, at the Faculty of Medicine of the University of Porto. His thesis was entitled "Study of descending pain modulation in an animal model of chemotherapy – induced neuropathy" Universidade do Porto Faculdade de Medicina, Portugal
2018 - Atual She took part, as a supervisor, in Ana Rita Alves da Silva's master's exams, within the scope of the Master's in Neurobiology at FMUP. The title of his thesis was “From poison to clinical application: Is botulinum toxin A treatment for pain arising after spinal cord injury?”. Universidade do Porto Faculdade de Medicina, Portugal
2018 - Atual Part of the jury for the master's degree exams of graduate Jorge Miguel Cibrão Ribeiro within the scope of the Master's in Health Sciences (University of Minho). His thesis was entitled “Assessment of the therapeutic effects of adipose mesenchyma stem cells secretome on a mouse spinal cord injury model”. Discussed the thesis. Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - Atual Júri de ano probatório da licenciada Maria Teresa Ferreira de Faria de Sousa Pereira no Programa Doutoral em Medicina da Faculdade de Medicina da Universidade do Porto, tendo discutido o relatório referente ao primeiro ano de trabalho. O título provisório da sua tese é “Estudo das alterações cardíacas ictais: possível relação com a morte súbita na epilepsia”. Universidade do Porto Faculdade de Medicina, Portugal
2017 - Atual Arguente do relatório referente ao projeto de Opção - Estágio Final (6º ano do Mestrado Integrado em Medicina), elaborado por Guilherme José da Silva Correia. O título do relatório era “Combination of GRGDSgrafted Gellan Gum hydrogel with Cellular therapy and Riluzole treatment for Spinal Cord Injury Regeneration”. Universidade do Porto Faculdade de Medicina, Portugal
2017 - Atual She took part, as a supervisor, in Helena Isabel Alvites Cavaleiro's master's exams in the Master's in Neurobiology at FMUP. His thesis was titled “"Is TRPV1 involved in pain and bladder dysfunction associated with multiple sclerosis? An experimental study in the rat." Universidade do Porto Faculdade de Medicina, Portugal
2014 - Atual As a supervisor, she was part of the jury for the master's exams of graduate André Ferreira Canelas in the Integrated Master's Degree in Medicine at the Faculty of Medicine of the University of Porto, having discussed the dissertation entitled "Sympathetic nervous system and visceral pain: the case of the bladder pain syndrome”. Universidade do Porto Faculdade de Medicina, Portugal
2014 - Atual As a supervisor, she was part of the jury for the master's exams of graduate João Paulo Garrido Vieira dos Santos in the Integrated Master's Degree in Medicine at the Faculty of Medicine of the University of Porto, having discussed the dissertation entitled "Molecular mechanisms involved in neurogenic detrusor overactivity” Universidade do Porto Faculdade de Medicina, Portugal
2013 - Atual Júri de ano probatório do licenciado Tiago Vieira Conceição Antunes Lopes no Programa Doutoral em Medicina da Faculdade de Medicina da Universidade do Porto, tendo discutido o relatório referente ao primeiro ano trabalho. O título provisório da tese é “The role of neurotrophic factors in lower urinary tract dysfunctions: clinical and pathophysiological implications”. Universidade do Porto Faculdade de Medicina, Portugal
2013 - Atual Part of the jury, as supervisor, for the doctoral exams of Master Bárbara Filipa Frias Garrido, student in the Doctoral Program in Neurosciences at the Faculty of Medicine of the University of Porto, with the thesis entitled “The importance of the neurotrophins NGF and BDNF in bladder dysfunction. An experimental study in the rat.” Universidade do Porto Faculdade de Medicina, Portugal
2013 - Atual Member of the jury for the doctoral exams of Master Ana Cristina Martins Pinto Coelho, student in the Doctoral Program in Neurosciences at the Faculty of Medicine of the University of Porto, with the thesis entitled “Mechanisms of action of botulinum toxin in the treatment of overactive bladder” Universidade do Porto Faculdade de Medicina, Portugal
2011 - Atual Júri de ano probatório do licenciado João Manuel de Sousa Valente no Programa Doutoral em Neurociências da FMUP, tendo discutido o relatório referente ao primeiro ano de trabalho. O título provisório da tese era “The role of N-arachidonoyl phosphatidylethanolamine phospholipase D in regulating the activity of primary sensory neurons in naive and inflammatory conditions”. Universidade do Porto Faculdade de Medicina, Portugal
2010 - Atual Part of the jury for the master's exams of Gisela Patrícia da Silva Borges in the Master's in Biology at FCUP, having discussed the dissertation entitled "Effect of applying a noxious stimulus and chronic treatment with Amitriptyline in a model of chronic pain neuropathic - expression of pERKs in brain nuclei of the Brain Stem” Universidade do Porto Faculdade de Ciências, Portugal
2010 - Atual Part of the jury for the master's exams of Mariana Sofia Silva Afonso in the Integrated Master's Degree in Medicine at the Faculty of Medicine of the University of Porto, having discussed the dissertation entitled "Role of glial cells in neuropathic pain: potential therapeutic advantages with the use of opioids”. Universidade do Porto Faculdade de Medicina, Portugal
2009 - Atual Part of the jury for the master's exams of graduate Rui Miguel de Almeida Pinto in the Master's in Medicine and Molecular Oncology at FMUP, as co-supervisor, with the master's thesis entitled "Activation of the intracellular signaling pathways of ERKs 1 and 2 and of p38 in transitional cell carcinomas of the bladder”. Universidade do Porto Faculdade de Medicina, Portugal
2009 - Atual Part of the jury of the master's exams of graduate Bárbara Filipa Frias Garrido in the Master's in Biochemistry at FCUP, as supervisor, with the master's thesis entitled "Contribution of NGF and BDNF for referred pain and bladder overactivity in an animal model of chronic bladder inflammation” Universidade do Porto Faculdade de Ciências, Portugal

Tutoria

Tópico Nome do aluno
2022/02/20 - Atual Neuroprotectjon and neuroregeneration for spinal cord Injury repair. CARLA SOFIA DA SILVA SOUSA
2019 - Atual Moving Towards Personalized Medicine: Analysis of Immune Profiles and Sensorimotor Recovery Patterns in Spinal Cord Injury Patients Natália Luísa Vasconcelos Pereira
2015 - 2018 Combination of Cellular Therapy with Peptide-modified Gellan Gum Hydrogels for Spinal Cord Injury Repair Eduardo Domingos Correia Gomes
Distinções

Prémio

2022 Prize for the best article “Neurotrophins and visceral pain: the particular case of neuronal growth factor (NGF) and brain-derived neurotrophic factor (BDNF)”. Revista Dor.
2018 Best poster. "Aging-associated underactive bladder involves a decrease in urethral serotonin release by 5HT-expressing cells. An experimental study in the rat. 48th Annual Meeting of the International Continence Society. Philadelphia, USA.
2017 Prize for the best article “Pathophysiological mechanisms of interstitial cystitis/bladder pain syndrome (IC/VSD)” (last author). Revista Dor.
2016 Melo e Castro Award for the project “INSPIReD – Bladder dysfunction after vertebromedullary injuries: identification of the mechanisms of appearance and maintenance of neurogenic detrusor hyperactivity and detrusor-sphincter dyssynergia”, Santa Casa da Mi
Santa Casa da Misericórdia de Lisboa, Portugal
2016 Award for the best article from Revista Dor for the work “Intrathecal application of botulinum toxin improves pain and urinary symptoms caused by interstitial cystitis. Experimental study carried out on rats” (co-author).
2015 First prize for the work "Selective impairment of bladder afferents by botulinum toxin type A improves neurogenic detrusor overactivity: tracking new possibilities”, Young Talents Award, by the Swiss Continence Society (co-author).
2013 1st Prize. “Intrathecal administration of botulinum toxin type A improves urinary bladder function"
Fundação Grünenthal, Portugal
2011 First prize for best abstract (non-oncology) for "Urinary levels of Brain Derived Neurotrophic Factor in women with overactive bladder syndrome correlate with the severity of symptoms"
European Association of Urology, Países Baixos
2011 Menção honrosa para o trabalho: “NGF and BDNF modulate referred pain and bladder hyperactivity in chronic cystitis”. Prémio Grünenthal Dor, atribuído pela Fundação Grünenthal (última autora).
2010 Best Poster. “O bloqueio intratecal de NGF diminui a dor referida e hiperactividade vesical em animais com cistite”
2010 Best oral communication "“Intrathecal NGF blockade reduces referred pain and bladder hyperactivity in rats with cystitis”. 8º Convénio da ASTOR (Associação para o Desenvolvimento da Terapia da Dor), Lisboa, Portugal (last author).
2009 Menção honrosa. “Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis.”
Fundação Grünenthal, Portugal
2008 Scientific interest and merit. “Avaliação dos níveis de fosforilação das ERKs 1 e 2 como factor de prognóstico”
2004 1st Prize. “As cínases de regulação extracelular –1 e –2 (ERK 1 e 2) medeiam a dor e a actividade reflexogénica da bexiga causadas pela inflamação crónica da bexiga”
Fundação Grünenthal, Portugal
2003 2nd Prize: “Expressão do receptor vanilóide (VR1) no tracto urinário do rato”
Fundação Grünenthal, Portugal
2001 Best session poster: "Bladder sensory fibers immunoreactive to the vanilloid receptor type 1 (VR1)"
European Association of Urology, Países Baixos

Outra distinção

2012 2012 - Best session poster: "High urinary levels of nerve growth factor and brain-derived neurotrophic factor in women with overactive bladder syndrome normalize after lifestyle intervention and antimuscarinic therapy".