Identificação pessoal

Nome completo

Pedro Henrique Magalhães Fernandes Pais

Nomes de citação

• Pais, Pedro

Identificadores de autor

Ciência ID

7212-18FA-8EDA

ORCID iD

0000-0001-5628-416X

Endereços de correio eletrónico

• pedrohpais@tecnico.ulisboa.pt (Profissional)

Telefones

Telemóvel

• 912682366 (Pessoal)

Moradas

• Av. Rovisco Pais, 1049-001, Lisboa, Lisboa, Portugal (Profissional)
• Rua Aura Abranches, nº8, 4º esquerdo, 1500-067, Benfica, Lisboa, Portugal (Pessoal)

Websites

• http://ibb.tecnico.ulisboa.pt/phdPP.html (Profissional)

Domínios de atuação

• Ciências Naturais - Ciências Biológicas - Microbiologia
• Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Alemão	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador independente (B1)

	Grau	Classificação
2015/09 - 2019/09 Concluído	Biotecnologia e Biociências (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal "Unveiling the complex regulatory network governing antifungal drug resistance in Candida glabrata: from new regulators to new effectors" (TESE/DISSERTAÇÃO)
2012/09 - 2014/07 Concluído	Biotecnologia (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal "The membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the drug:H+ antiporters CgTpo1_1 and CgTpo1_2" (TESE/DISSERTAÇÃO)	18
2009/09 - 2012/07 Concluído	Biologia Celular e Molecular (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal	16

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2020/01 - Atual	Pós-doutorado (Investigação)	Universidade de Lisboa Instituto Superior Técnico, Portugal
	Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/09 - 2019/12	Investigador Contratado (Investigação)	Universidade de Lisboa Instituto Superior Técnico, Portugal

Bolsa

	Designação	Financiadores
2019/09 - 2019/12	BIODATA - Portuguese Infrastructure of Biological Data o LISBOA-01-0145-FEDER-022231 Bolseiro de Investigação	Em curso

Projeto

	Designação	Financiadores
2020/01 - Atual	MIXED-UP – Targeting pathogenesis and engineering cell factories: by developing mixed regulatory-metabolic genomic models in yeasts PTDC/BII-BIO/28216/2017 Bolseiro de Pós-Doutoramento	Em curso
2015/09 - 2019/10	CANTROL - Deciphering the mechanisms of transcriptional regulation that control antifungal drug resistance in the pathogenic yeast Candida glabrata: aiming the development of improved diagnosis and therapeutic approaches PTDC/BBB-BIO/4004/2014 Bolseiro de Doutoramento Universidade de Lisboa Instituto Superior Técnico, Portugal	Concluído
2013/09 - 2014/04	FUNDRING - Identification of new biomarkers of antiFUNgal Drug Resistance diagnosis IN Candida Glabrata: the particular role of multidrug resistance transporters PTDC/EBB-BIO/119356/2010 Outra Universidade de Lisboa Instituto Superior Técnico, Portugal	Concluído

Publicações

Artigo em revista	Mafalda Cavalheiro; Daniela Romão; Rui Santos; Dalila Mil-Homens; Pedro Pais; Catarina Costa; Mónica Galocha; et al. "Role of CgTpo4 in Polyamine and Antimicrobial Peptide Resistance: Determining Virulence in Candida glabrata". International Journal of Molecular Sciences 22 3 (2021): 1376-1376. https://doi.org/10.3390/ijms22031376. 10.3390/ijms22031376 Pais, Pedro. "Transcriptome-wide differences between Saccharomyces cerevisiae and Saccharomyces cerevisiae var. boulardii: Clues on host survival and probiotic activity based on promoter sequence variability". Genomics 113 2 (2021): 530-539. https://www.sciencedirect.com/science/article/pii/S0888754321000288?via%3Dihub. Publicado Pedro Pais; Vanda Almeida; Melike Yilmaz; Miguel C. Teixeira. "Saccharomyces boulardii: What Makes It Tick as Successful Probiotic?". Journal of Fungi (2020): https://doi.org/10.3390/jof6020078. 10.3390/jof6020078 Pais, Pedro. "A new regulator in the crossroads of oxidative stress resistance and virulence in Candida glabrata: The transcription factor CgTog1". Virulence 11 1 (2020): 1522-1538. http://dx.doi.org/10.1080/21505594.2020.1839231. 10.1080/21505594.2020.1839231 Monteiro PT; Oliveira J; Pais P; Antunes M; Palma M; Cavalheiro M; Galocha M; et al. "YEASTRACT+: a portal for cross-species comparative genomics of transcription regulation in yeasts.". Nucleic acids research (2019): http://europepmc.org/abstract/med/31586406. 10.1093/nar/gkz859 Pais P; Galocha M; Miranda IM; Rodrigues AG; Teixeira MC. "Draft Genome Sequences of Three Clinical Isolates of the Pathogenic Yeast Candida glabrata.". Microbiology resource announcements (2019): http://europepmc.org/abstract/med/31467089. 10.1128/MRA.00278-19 Mónica Galocha; Pedro Pais; Mafalda Cavalheiro; Diana Pereira; Romeu Viana; Miguel C. Teixeira. "Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin". International Journal of Molecular Sciences (2019): https://www.mdpi.com/1422-0067/20/9/2345. 10.3390/ijms20092345 Pais P; Galocha M; Viana R; Cavalheiro M; Pereira D; Teixeira MC. "Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection.". Microbial cell (Graz, Austria) (2019): http://europepmc.org/abstract/med/30854392. 10.15698/mic2019.03.670 Pais P; Galocha M; Teixeira MC. "Genome-Wide Response to Drugs and Stress in the Pathogenic Yeast Candida glabrata.". Progress in molecular and subcellular biology (2019): http://europepmc.org/abstract/med/30911893. 10.1007/978-3-030-13035-0_7 Cavalheiro M; Costa C; Silva-Dias A; Miranda IM; Wang C; Pais P; Pinto SN; et al. "A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate.". Antimicrobial agents and chemotherapy (2018): http://europepmc.org/abstract/med/30348666. 10.1128/AAC.00995-18 Cavalheiro M; Pais P; Galocha M; Teixeira MC. "Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!". Genes (2018): http://europepmc.org/abstract/med/30004464. 10.3390/genes9070332 Romão D; Cavalheiro M; Mil-Homens D; Santos R; Pais P; Costa C; Takahashi-Nakaguchi A; et al. "A New Determinant of Candida glabrata Virulence: The Acetate Exporter CgDtr1.". Frontiers in cellular and infection microbiology (2017): http://europepmc.org/abstract/med/29184852. 10.3389/fcimb.2017.00473 Pais, Pedro. "YEASTRACT: an upgraded database for the analysis of transcription regulatory networks in Saccharomyces cerevisiae.". Nucleic acids research (2017): http://europepmc.org/abstract/med/29036684. 10.1093/nar/gkx842 Santos R; Costa C; Mil-Homens D; Romão D; de Carvalho CC; Pais P; Mira NP; Fialho AM; Teixeira MC. "The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata.". (2017): http://europepmc.org/abstract/med/27780306. 10.1111/cmi.12686 Monteiro PT; Pais P; Costa C; Manna S; Sá-Correia I; Teixeira MC. "The PathoYeastract database: an information system for the analysis of gene and genomic transcription regulation in pathogenic yeasts.". (2017): http://europepmc.org/abstract/med/27625390. 10.1093/nar/gkw817 Pais P; Costa C; Pires C; Shimizu K; Chibana H; Teixeira MC. "Membrane Proteome-Wide Response to the Antifungal Drug Clotrimazole in Candida glabrata: Role of the Transcription Factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2.". (2016): http://europepmc.org/abstract/med/26512119. 10.1074/mcp.m114.045344 Pais P; Costa C; Cavalheiro M; Romão D; Teixeira MC. "Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison.". (2016): http://europepmc.org/abstract/med/27812511. Pais P; Pires C; Costa C; Okamoto M; Chibana H; Teixeira MC. "Membrane Proteomics Analysis of the Candida glabrata Response to 5-Flucytosine: Unveiling the Role and Regulation of the Drug Efflux Transporters CgFlr1 and CgFlr2.". (2016): http://europepmc.org/abstract/med/28066366. 10.3389/fmicb.2016.02045 Costa C; Ponte A; Pais P; Santos R; Cavalheiro M; Yaguchi T; Chibana H; Teixeira MC. "New Mechanisms of Flucytosine Resistance in C. glabrata Unveiled by a Chemogenomics Analysis in S. cerevisiae.". (2015): http://europepmc.org/abstract/med/26267134. 10.1371/journal.pone.0135110
Capítulo de livro	Cavalheiro M; Costa C; Pais, Pedro; Teixeira MC. "Acquisition of resistance to azole antifungal drugs in Candida species: imidazoles versus triazoles". In Advances in Medicine and Biology. Nova Science Publishers, 2016. Publicado Costa C; Pais, Pedro; Teixeira MC. "Multidrug resistance in pathogenic yeasts: emphasis on the role of ABC and MFS multidrug transporters". In The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs, 947-954. Formatex, 2015.
Poster em conferência	Galocha M; Silva-Dias A; Pais, Pedro; Cavalheiro M; Miranda IM; Chibana H; Rodrigues AG; Teixeira MC. "C. glabrata evolution towards posaconazole resistance irrespective of PDR1 GOF mutations". Trabalho apresentado em HFP2019 – Advanced Lecture Course in Molecular Mechanisms of Host-Pathogen Interactions and Virulence in Human Fungal Pathogens, 2019. Pais, Pedro; Galocha M; Califórnia R; Chibana H; Sá-Correia I; Monteiro PT; Butler G; Teixeira MC. "Fighting human candidiasis: the use of systems biology approaches". Trabalho apresentado em Encontro Ciência ‘18, 2018. Pais, Pedro; Galocha M; Monteiro PT; Teixeira MC. "PathoYeastract: a free web information system designed to fully exploit transcription regulation data in pathogenic yeasts". Trabalho apresentado em Annual Meeting of the Portuguese Society of Genetics, 2018. Pais, Pedro; Galocha M; Monteiro PT; Teixeira MC. "The PathoYeastract database: a tool for the study of transcription regulation in Candida species". Trabalho apresentado em 14th ASM Conference on Candida and Candidiasis, 2018. Cavalheiro M; Rui Santos; Romão D; Mil-Homens D; Pais, Pedro; Costa C; Viana R; et al. "Determining virulence by protecting the cell from host induced stresses: the unexpected role of C. glabrata multidrug transporters". Trabalho apresentado em MICROBIOTEC’17, 2017. Pais, Pedro; Galocha M; Cavalheiro M; Costa C; Califórnia R; Leitão C; Diana Pereira; Butler G; Teixeira MC. "Deciphering transcription regulation of antifungal drug resistance in the pathogenic yeast Candida glabrata". Trabalho apresentado em MICROBIOTEC’17, 2017. Pais, Pedro; Costa C; Pires C; Cavalheiro M; Teixeira MC. "Using pathoproteomics to unveil new players in antifungal drug resistance in the human pathogenic yeast Candida glabrata". 2017. Cavalheiro M; Rui Santos; Romão D; Mil-Homens D; Pais P; Costa C; Galocha M; Fialho AM; Teixeira MC. "A new role for C. glabrata drug:H+ antiporters: in the crossroad between drug resistance and virulence". 2017. Romão D; Rui Santos; Mil-Homens D; Costa C; Pais P; Fialho AM; Teixeira MC. "Role of uncharacterized drug:H+ antiporters in C. glabrata pathogenicity". 2016. Pais, Pedro; Costa C; Pires C; Romão D; Cavalheiro M; Teixeira MC. "Role of uncharacterized drug:H+ antiporters in C. glabrata pathogenicity". Trabalho apresentado em PYFF6 - 6th Conference on Physiology of Yeasts and Filamentous Fungi, 2016. Pais, Pedro; Costa C; Pires C; Rui Santos; Cavalheiro M; Teixeira MC. "New mechanisms of 5-flucytosine resistance in the human pathogen Candida glabrata: unveiled through chemogenomics and proteomics approaches". Trabalho apresentado em MICROBIOTEC'15, 2015. Pais, Pedro; Pires C; Costa C; Teixeira MC. "Membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the drug:H+ antiporters CgTpo1_1 and CgTpo1_2". Trabalho apresentado em Jornadas de Biologia de Leveduras Professor Nicolau Van Uden, 2014.
Recurso online	Pais, Pedro. Yeastract+ portal. 2019. http://www.yeastract.com/. Pais, Pedro. PathoYeastract database. 2017. http://pathoyeastract.org/. Pais, Pedro. Yeastract database. 2011. http://www.yeastract.com/.

Prémio

2015	2nd place of best poster presentation at Microbiotec’ 15

Outra distinção

2019	Microbiotec’19 FEMS Early Career Researcher Grant
2019	29th ECCMID Travel Grant
2017	HFP2017 Young Scientist’s Meeting Grant
2016	PYFF6 Young Scientist Meeting Grant