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Identificação

Identificação pessoal

Nome completo
Francisco Javier Otero Espinar

Nomes de citação

  • Espinar, Francisco

Identificadores de autor

Ciência ID
7511-1D58-A878
ORCID iD
0000-0001-9030-2253
Formação
Grau Classificação
2001
Concluído
Especialista en Farmacia Industrial e Galenica (Doctor)
Especialização em Farmacia e Tecnología Farmaceutica
Universidade de Santiago de Compostela, Espanha
2001
Concluído
Especialista en Análisis e Control en Medicamentos e Drogas (Doctor)
Universidade de Santiago de Compostela - Campus Vida, Espanha
1982 - 1987
Concluído
Licenciado en Farmacia (Doctor)
Universidade de Santiago de Compostela - Campus Vida, Espanha
"Complejos de inclusión con ciclodextrinas como sistemas para mejorar las características biofarmacéuticas del naproxen" (TESE/DISSERTAÇÃO)
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento
Empregador
2019 - 2033 Professor Catedrático (Docente Universitário) Universidade de Santiago de Compostela - Campus Vida, Espanha
Universidade de Santiago de Compostela - Campus Vida, Espanha
1995 - 2019 Professor Associado (Docente Universitário) Universidade de Santiago de Compostela - Campus Vida, Espanha
1990 - 1995 Professor Auxiliar (Docente Universitário) Universidade de Santiago de Compostela - Campus Vida, Espanha
Produções

Publicações

Artigo em conferência
  1. A Fernández-Ferreiro; M González-Barcia; L Garcia-Quintanilla; A Luaces; V Díaz-Tome; R Touriño-Peralba; I Alonso-Rodriguez; et al. "PP-015 Tacrolimus eye drops as a therapeutic alternative for paediatric patients with inflammatory ocular surface diseases". 2017.
    10.1136/ejhpharm-2017-000640.462
  2. A Fernández-Ferreiro; M González-Barcia; L Garcia-Quintanilla; A Luaces; V Díaz-Tome; I Alonso-Rodriguez; X Garcia-Otero; M Lamas; FJ Otero-Espinar. "PP-016 Effect of tacrolimus eye drops on human primary corneal epithelial cells". 2017.
    10.1136/ejhpharm-2017-000640.463
Artigo em revista
  1. Laura García-Quintanilla; Pablo Almuiña-Varela; María José Rodríguez-Cid; María Gil-Martínez; Maximino J. Abraldes; Francisco Gómez-Ulla; Miguel González-Barcia; et al. "The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16010105.
    10.3390/pharmaceutics16010105
  2. Ana Castro Balado; Andrea Cuartero-Martínez; Hugo Pena-Verdeal; Gonzalo Hermelo-Vidal; Anja Schmidt; Belén Montero; Manuela Hernández-Blanco; et al. "Cysteamine Eye Drops in Hyaluronic Acid Packaged in Innovative Single-Dose Systems, Part II: Long-Term Stability and Clinical Ocular Biopermanence". Pharmaceutics 15 11 (2023): 2589-2589. http://dx.doi.org/10.3390/pharmaceutics15112589.
    10.3390/pharmaceutics15112589
  3. Manuel Gago-Guillán; Xurxo García-Otero; Soledad Anguiano-Igea; Francisco J. Otero-Espinar. "Compression pressure-induced synergy in xanthan and locust bean gum hydrogels. Effect in drug delivery". Journal of Drug Delivery Science and Technology (2023): https://doi.org/10.1016/j.jddst.2023.105025.
    10.1016/j.jddst.2023.105025
  4. Uxía Regueiro; Maite López-López; Rubén Varela-Fernández; Francisco Javier Otero-Espinar; Isabel Lema. "Biomedical Applications of Lactoferrin on the Ocular Surface". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15030865.
    10.3390/pharmaceutics15030865
  5. Eloy Pena-Rodríguez; Teresa García-Berrocoso; Ezequiel Vázquez Fernández; Francisco J. Otero-Espinar; Joaquin Abian; Francisco Fernández-Campos. "Monitoring dexamethasone skin biodistribution with ex vivo MALDI-TOF mass spectrometry imaging and confocal Raman microscopy". International Journal of Pharmaceutics (2023): 122808-122808. http://dx.doi.org/10.1016/j.ijpharm.2023.122808.
    10.1016/j.ijpharm.2023.122808
  6. Guillermo Blanco-Fernandez; Barbara Blanco-Fernandez; Anxo Fernández-Ferreiro; Francisco J. Otero-Espinar. "Lipidic lyotropic liquid crystals: Insights on biomedical applications". Advances in Colloid and Interface Science (2023): 102867-102867. http://dx.doi.org/10.1016/j.cis.2023.102867.
    10.1016/j.cis.2023.102867
  7. Iria Varela-Rey; Daniel de la Iglesia; Alba San Bruno-Ruz; Rafael Mejuto-Fernández; Luz Monteserín-Ron; Javier López-Diaz; Pedro García-Salom; et al. "Design and biopharmaceutical preclinical characterisation of a new thermosensitive hydrogel for the removal of gastric polyps". International Journal of Pharmaceutics (2023): 122706-122706. http://dx.doi.org/10.1016/j.ijpharm.2023.122706.
    10.1016/j.ijpharm.2023.122706
  8. Castro-Balado, Ana; Novo-Veleiro, Ignacio; Vázquez-Agra, Néstor; Barbeito-Castiñeiras, Gema; Estany-Gestal, Ana; Trastoy-Pena, Rocío; González-Barcia, Miguel; et al. "Efficacy and Safety of Inhaled Ethanol in Early-Stage SARS-CoV-2 Infection in Older Adults: A Phase II Randomized Clinical Trial". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/2/667.
    10.3390/pharmaceutics15020667
  9. Zalacain-Vicuña, A.J.; Nieto, C.; Picas, J.; Martínez, H.; Bermejo, R.; Corrales, A.; Campos, F.F.; et al. "Efficacy and safety of a new medicated nail hydrolacquer in the treatment of adults with toenail onychomycosis: A randomised clinical trial". Mycoses 66 7 (2023): 566-575. http://www.scopus.com/inward/record.url?eid=2-s2.0-85142293374&partnerID=MN8TOARS.
    10.1111/myc.13543
  10. Bendicho-Lavilla, C.; Seoane-Viaño, I.; Santos-Rosales, V.; Díaz-Tomé, V.; Carracedo-Pérez, M.; Luzardo-Álvarez, A.M.; García-González, C.A.; Otero-Espinar, F.J.. "Intravitreal implants manufactured by supercritical foaming for treating retinal diseases". Journal of Controlled Release 362 (2023): 342-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-85169801626&partnerID=MN8TOARS.
    10.1016/j.jconrel.2023.08.047
  11. Victoria Díaz Tomé; Carlos Bendicho-Lavilla; Xurxo García-Otero; Rubén Varela-Fernández; Manuel Martin-Pastor; José Llovo-Taboada; Pilar Alonso-Alonso; et al. "Antifungal Combination Eye Drops for Fungal Keratitis Treatment". Pharmaceutics 15 1 (2022): 35-35. http://dx.doi.org/10.3390/pharmaceutics15010035.
    10.3390/pharmaceutics15010035
  12. Ana Castro Balado; Enrique Bandín-Vilar; Andrea Cuartero-Martínez; Laura García-Quintanilla; Gonzalo Hermelo-Vidal; Xurxo García-Otero; Lorena Rodríguez-Martínez; et al. "Cysteamine Eye Drops in Hyaluronic Acid Packaged in Innovative Single-Dose Systems: Stability and Ocular Biopermanence". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/10/2194.
    10.3390/pharmaceutics14102194
  13. Cristina Moles-Aranda; Noelia Pérez-González; Ana C. Calpena-Campmany; María J. Martín-Villena; Francisco J. Otero-Espinar; Patricia Severino; Eliana B. Souto; José A. Morales-Molina; Beatriz Clares-Naveros. "Preparation and ex vivo investigation of an injectable microparticulate formulation for gastrointestinal mucosa polyp resection". European Journal of Pharmaceutics and Biopharmaceutics (2022): https://doi.org/10.1016/j.ejpb.2022.07.012.
    10.1016/j.ejpb.2022.07.012
  14. "Mucoadhesive PLGA Nanospheres and Nanocapsules for Lactoferrin Controlled Ocular Delivery". Pharmaceutics (2022): http://dx.doi.org/10.3390/pharmaceutics14040799.
    10.3390/pharmaceutics14040799
  15. "Bringing lipidic lyotropic liquid crystal technology into biomedicine". Trends in Pharmacological Sciences (2022): http://dx.doi.org/10.1016/j.tips.2022.03.004.
    10.1016/j.tips.2022.03.004
  16. Carlos Bendicho-Lavilla; Iria Seoane-Viaño; Francisco J. Otero-Espinar; Asteria Luzardo-Álvarez. "Fighting type 2 diabetes: Formulation strategies for peptide-based therapeutics". Acta Pharmaceutica Sinica B (2022): https://doi.org/10.1016/j.apsb.2021.08.003.
    10.1016/j.apsb.2021.08.003
  17. García-Otero, X.; Mondelo-García, C.; Bandín-Vilar, E.; Gómez-Lado, N.; Silva-Rodríguez, J.; Rey-Bretal, D.; Victoria Otero-Espinar, M.; et al. "PET study of intravitreal adalimumab pharmacokinetics in a uveitis rat model". International Journal of Pharmaceutics 627 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139733758&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2022.122261
  18. Cuartero-Martínez, A.; Hermelo-Vidal, G.; Castro-Balado, A.; Gómez-García, Á.; González-Barcia, M.; Otero-Espinar, F.J.; Fernández-Ferreiro, A.; Mondelo-García, C.. "Stability of insulin eye drops in the treatment of refractory corneal ulcers,Estabilidad del colirio de insulina para el tratamiento de úlceras corneales refractarias". Farmacia Hospitalaria 46 6 (2022): 335-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-85143983610&partnerID=MN8TOARS.
    10.7399/fh.13293
  19. Varela-Fernández, R.; García-Otero, X.; Díaz-Tomé, V.; Regueiro, U.; López-López, M.; González-Barcia, M.; Isabel Lema, M.; Javier Otero-Espinar, F.. "Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular drug delivery". European Journal of Pharmaceutics and Biopharmaceutics 172 (2022): 144-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124982664&partnerID=MN8TOARS.
    10.1016/j.ejpb.2022.02.010
  20. González-Barcia, M.; Mondelo-García, C.; Otero-Espinar, F.J.; Fernández-Ferreiro, A.. "Selected evidence and cherry picking pharmaceutical compounding,Evidencia seleccionada y cherry picking en formulación magistral". Farmacia Hospitalaria 46 2 (2022): 100-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127498943&partnerID=MN8TOARS.
    10.7399/fh.13230
  21. Varela-Fernández, R.; Bendicho-Lavilla, C.; Martin-Pastor, M.; Herrero Vanrell, R.; Lema-Gesto, M.I.; González-Barcia, M.; Otero-Espinar, F.J.. "Design, optimization, and in vitro characterization of idebenone-loaded PLGA microspheres for LHON treatment". International Journal of Pharmaceutics 616 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85123882843&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2022.121504
  22. Xurxo García-Otero; Cristina Mondelo-García; Francisco González; Roman Perez-Fernandez; Leandro Avila; Jose Ramón Antúnez-López; Miguel González-Barcia; et al. "Anti-Inflammatory Effect of Tacrolimus/Hydroxypropyl-ß-Cyclodextrin Eye Drops in an Endotoxin-Induced Uveitis Model". Pharmaceutics 13 10 (2021): 1737-1737. https://doi.org/10.3390/pharmaceutics13101737.
    10.3390/pharmaceutics13101737
  23. Elías Quezada; Fernanda Rodríguez-Enríquez; Reyes Laguna; Elena Cutrín; Francisco Otero; Eugenio Uriarte; Dolores Viña. "Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders". Molecules (2021): https://doi.org/10.3390/molecules26154550.
    10.3390/molecules26154550
  24. José V. Álvarez; Susana B. Bravo; María Pilar Chantada-Vázquez; Sofía Barbosa-Gouveia; Cristóbal Colón; Olalla López-Suarez; Shunji Tomatsu; Francisco J. Otero-Espinar; María L. Couce. "Plasma Proteomic Analysis in Morquio A Disease". International Journal of Molecular Sciences 22 11 (2021): 6165-6165. https://doi.org/10.3390/ijms22116165.
    10.3390/ijms22116165
  25. Victoria Díaz-Tomé; Xurxo García-Otero; Rubén Varela-Fernández; Manuel Martín-Pastor; Andrea Conde-Penedo; Pablo Aguiar; Miguel González-Barcia; Anxo Fernández-Ferreiro; Francisco J Otero-Espinar. "In situ forming and mucoadhesive ophthalmic voriconazole/HPßCD hydrogels for the treatment of fungal keratitis". International Journal of Pharmaceutics (2021):
    10.1016/j.ijpharm.2021.120318
  26. Ana Castro Balado; Cristina Mondelo-García; Letricia Barbosa-Pereira; Iria Varela-Rey; Ignacio Novo-Veleiro; Néstor Vázquez-Agra; José Ramón Antúnez-López; et al. "Development and Characterization of Inhaled Ethanol as a Novel Pharmacological Strategy Currently Evaluated in a Phase II Clinical Trial for Early-Stage SARS-CoV-2 Infection". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/3/342.
    10.3390/pharmaceutics13030342
  27. Rubén Varela-Fernández; Xurxo García-Otero; Victoria Díaz-Tomé; Uxía Regueiro; Maite López-López; Miguel González-Barcia; María Isabel Lema; Francisco Javier Otero-Espinar. "Design, Optimization, and Characterization of Lactoferrin-Loaded Chitosan/TPP and Chitosan/Sulfobutylether-ß-cyclodextrin Nanoparticles as a Pharmacological Alternative for Keratoconus Treatment". ACS Applied Materials & Interfaces (2021): https://doi.org/10.1021/acsami.0c18926.
    10.1021/acsami.0c18926
  28. Xurxo Garcia-Otero; Victoria Díaz Tomé; Rubén Varela-Fernández; Manuel Martín-Pastor; Miguel González-Barcia; José Blanco Méndez; Cristina Mondelo-García; et al. "Development and Characterization of a Tacrolimus/Hydroxypropyl-ß-Cyclodextrin Eye Drop". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/2/149.
    10.3390/pharmaceutics13020149
  29. Varela-Fernández, R.; Lema-Gesto, M.I.; González-Barcia, M.; Otero-Espinar, F.J.. "Design, development, and characterization of an idebenone-loaded poly-e-caprolactone intravitreal implant as a new therapeutic approach for LHON treatment". European Journal of Pharmaceutics and Biopharmaceutics 168 (2021): 195-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115015543&partnerID=MN8TOARS.
    10.1016/j.ejpb.2021.09.001
  30. Mondelo-García, C.; Bandín-Vilar, E.; García-Quintanilla, L.; Castro-Balado, A.; del Amo, E.M.; Gil-Martínez, M.; Blanco-Teijeiro, M.J.; et al. "Current Situation and Challenges in Vitreous Substitutes". Macromolecular Bioscience 21 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105972063&partnerID=MN8TOARS.
    10.1002/mabi.202100066
  31. Conde Penedo, A.; Díaz Tomé, V.; Fernández Ferreiro, A.; González Barcia, M.; Otero Espinar, F.J.. "Enhancement in corneal permeability of riboflavin using cyclodextrin derivates complexes as a previous step to transepithelial cross-linking". European Journal of Pharmaceutics and Biopharmaceutics 162 (2021): 12-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102075112&partnerID=MN8TOARS.
    10.1016/j.ejpb.2021.02.012
  32. Krambeck, K.; Silva, V.; Silva, R.; Fernandes, C.; Cagide, F.; Borges, F.; Santos, D.; et al. "Design and characterization of Nanostructured lipid carriers (NLC) and Nanostructured lipid carrier-based hydrogels containing Passiflora edulis seeds oil". International Journal of Pharmaceutics 600 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102553849&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2021.120444
  33. Herbada, R.S.; Torres-Suárez, A.I.; Otero-Espinar, F.J.; Fraguas-Sanchez, A.I.; Lopez-Cabarcos, E.; Rubio-Retama, J.; Fernández-Carballido, A.. "Matrix tablets based on a novel poly (magnesium acrylate) hydrogel for the treatment of inflammatory bowel diseases". International Journal of Pharmaceutics 608 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85115969922&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2021.121121
  34. Víctor J. Álvarez; Susana B. Bravo; Maria Pilar Chantada-Vazquez; Cristóbal Colón; María J. De Castro; Montserrat Morales; Isidro Vitoria; et al. "Characterization of New Proteomic Biomarker Candidates in Mucopolysaccharidosis Type IVA". International Journal of Molecular Sciences 22 1 (2020): 226-226. https://doi.org/10.3390/ijms22010226.
    10.3390/ijms22010226
  35. Iria Seoane-Viaño; Noemí Gómez-Lado; Héctor Lázare-Iglesias; Xurxo García-Otero; José Ramón Antúnez-López; Álvaro Ruibal; Juan Jesús Varela-Correa; et al. "3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of Inflammatory Bowel Disease". Biomedicines 8 12 (2020): 563-563. https://doi.org/10.3390/biomedicines8120563.
    10.3390/biomedicines8120563
  36. Ana Castro Balado; Cristina Mondelo-García; Iria Varela-Rey; Beatriz Moreda-Vizcaíno; Jesús F. Sierra-Sánchez; María Teresa Rodríguez-Ares; Gonzalo Hermelo-Vidal; et al. "Recent Research in Ocular Cystinosis: Drug Delivery Systems, Cysteamine Detection Methods and Future Perspectives". Pharmaceutics (2020): https://www.mdpi.com/1999-4923/12/12/1177.
    10.3390/pharmaceutics12121177
  37. Francisco Fernández-Campos; Francesc Navarro; Adrian Corrales; Jordi Picas; Eloy Pena; Jordi González; Francisco J. Otero-Espinar. "Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer". Pharmaceutics 12 8 (2020): 730-730. https://doi.org/10.3390/pharmaceutics12080730.
    10.3390/pharmaceutics12080730
  38. Roseline Mazet; Xurxo García-Otero; Luc Choisnard; Denis Wouessidjewe; Vincent Verdoot; Frédéric Bossard; Victoria Díaz-Tomé; et al. "Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery". Pharmaceutics 12 8 (2020): 717-717. https://doi.org/10.3390/pharmaceutics12080717.
    10.3390/pharmaceutics12080717
  39. Cristina Moles-Aranda; Ana C. Calpena-Campmany; Lyda Halbaut-Bellowa; Victoria Díaz-Tomé; Francisco J. Otero-Espinar; José A. Morales-Molina; Beatriz Clares-Naveros. "Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy". Pharmaceutics 12 4 (2020): 322-322. https://doi.org/10.3390/pharmaceutics12040322.
    10.3390/pharmaceutics12040322
  40. Rubén Varela-Fernández; Victoria Díaz-Tomé; Andrea Luaces-Rodríguez; Andrea Conde-Penedo; Xurxo García-Otero; Asteria Luzardo-Álvarez; Anxo Fernández-Ferreiro; Francisco J. Otero-Espinar. "Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations". Pharmaceutics (2020): https://doi.org/10.3390/pharmaceutics12030269.
    10.3390/pharmaceutics12030269
  41. Sara Blanco-Dorado; Maria Dolores Belles Medall; Oscar Pascual-Marmaneu; Manuel Campos-Toimil; Francisco Javier Otero-Espinar; Rafael Rodríguez-Riego; Teresa Rodríguez-Jato; et al. "Therapeutic drug monitoring of voriconazole: validation of a high performance liquid chromatography method and comparison with an ARK immunoassay". European Journal of Hospital Pharmacy (2020): https://doi.org/10.1136/ejhpharm-2019-002155.
    10.1136/ejhpharm-2019-002155
  42. Espinar, Francisco. "A multicenter prospective study evaluating the impact of Proton Pump Inhibitors omeprazole and pantoprazole on voriconazole plasma concentrations". British Journal of Clinical Pharmacology n/a n/a (2020): https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bcp.14267.
    10.1111/bcp.14267
  43. Kazuki Sawamoto; José Álvarez González; Matthew Piechnik; Francisco Otero; Maria Couce; Yasuyuki Suzuki; Shunji Tomatsu. "Mucopolysaccharidosis IVA: Diagnosis, Treatment, and Management". International Journal of Molecular Sciences 21 4 (2020): 1517-1517. https://doi.org/10.3390/ijms21041517.
    10.3390/ijms21041517
  44. Blanco-Dorado, S.; Maroñas, O.; Latorre-Pellicer, A.; Rodríguez Jato, M.T.; López-Vizcaíno, A.; Gómez Márquez, A.; Bardán García, B.; et al. "Impact of CYP2C19 Genotype and Drug Interactions on Voriconazole Plasma Concentrations: A Spain Pharmacogenetic-Pharmacokinetic Prospective Multicenter Study". Pharmacotherapy 40 1 (2020): 17-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077792976&partnerID=MN8TOARS.
    10.1002/phar.2351
  45. Luaces-Rodríguez, A.; Mondelo-García, C.; Zarra-Ferro, I.; González-Barcia, M.; Aguiar, P.; Fernández-Ferreiro, A.; Otero-Espinar, F.J.. "Intravitreal anti-VEGF drug delivery systems for age-related macular degeneration". International Journal of Pharmaceutics 573 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076213292&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2019.118767
  46. Espinar, Francisco. "Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers". Pharmaceutics (2020): https://www.mdpi.com/1999-4923/12/3/231.
    10.3390/pharmaceutics12030231
  47. Tavares, W.S.; Tavares-Júnior, A.G.; Otero-Espinar, F.J.; Martín-Pastor, M.; Sousa, F.F.O.. "Design of ellagic acid-loaded chitosan/zein films for wound bandaging". Journal of Drug Delivery Science and Technology 59 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85088221745&partnerID=MN8TOARS.
    10.1016/j.jddst.2020.101903
  48. Seoane-Viaño, I.; Ong, J.J.; Luzardo-Álvarez, A.; González-Barcia, M.; Basit, A.W.; Otero-Espinar, F.J.; Goyanes, A.. "3D printed tacrolimus suppositories for the treatment of ulcerative colitis". Asian Journal of Pharmaceutical Sciences (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090344780&partnerID=MN8TOARS.
    10.1016/j.ajps.2020.06.003
  49. Sawamoto, K.; Álvarez, J.V.; Herreño, A.M.; Otero-Espinar, F.J.; Couce, M.L.; Alméciga-Díaz, C.J.; Tomatsu, S.. "Bone-Specific Drug Delivery for Osteoporosis and Rare Skeletal Disorders". Current Osteoporosis Reports 18 5 (2020): 515-525. http://www.scopus.com/inward/record.url?eid=2-s2.0-85089908614&partnerID=MN8TOARS.
    10.1007/s11914-020-00620-4
  50. Krambeck, K.; Santos, D.; Otero-Espinar, F.; Sousa Lobo, J.M.; Amaral, M.H.. "Lipid nanocarriers containing Passiflora edulis seeds oil intended for skin application". Colloids and Surfaces B: Biointerfaces 193 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85084184479&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2020.111057
  51. Luaces-Rodríguez, A.; del Amo, E.M.; Mondelo-García, C.; Gómez-Lado, N.; Gonzalez, F.; Ruibal, Á.; González-Barcia, M.; et al. "PET study of ocular and blood pharmacokinetics of intravitreal bevacizumab and aflibercept in rats". European Journal of Pharmaceutics and Biopharmaceutics 154 (2020): 330-337. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088986290&partnerID=MN8TOARS.
    10.1016/j.ejpb.2020.06.024
  52. J. Álvarez; Carolina Herrero Filgueira; Alexandre González; Cristóbal Colón Mejeras; Andrés Beiras Iglesias; Shunji Tomatsu; José Blanco Méndez; et al. "Enzyme-Loaded Gel Core Nanostructured Lipid Carriers to Improve Treatment of Lysosomal Storage Diseases: Formulation and In Vitro Cellular Studies of Elosulfase Alfa-Loaded Systems". Pharmaceutics 11 10 (2019): 522-522. https://doi.org/10.3390/pharmaceutics11100522.
    10.3390/pharmaceutics11100522
  53. J. Víctor Álvarez; Susana B. Bravo; María García-Vence; María J. De Castro; Asteria Luzardo; Cristóbal Colón; Shunji Tomatsu; Francisco J. Otero-Espinar; María L. Couce. "Proteomic Analysis in Morquio A Cells Treated with Immobilized Enzymatic Replacement Therapy on Nanostructured Lipid Systems". International Journal of Molecular Sciences (2019): https://doi.org/10.3390/ijms20184610.
    10.3390/ijms20184610
  54. Lucía Álvarez-Álvarez; Luis Barral; Rebeca Bouza; Yousof Farrag; Francisco Otero-Espinar; Sandra Feijóo-Bandín; Francisca Lago. "Hydrocortisone loaded poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for topical ophthalmic administration: Preparation, characterization and evaluation of ophthalmic toxicity". International Journal of Pharmaceutics 568 (2019): 118519-118519. https://doi.org/10.1016/j.ijpharm.2019.118519.
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  55. Laura García-Quintanilla; Andrea Luaces-Rodríguez; María Gil-Martínez; Cristina Mondelo-García; Olalla Maroñas; Víctor Mangas-Sanjuan; Miguel González-Barcia; et al. "Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration". Pharmaceutics 11 8 (2019): 365-365. https://doi.org/10.3390/pharmaceutics11080365.
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  56. Asteria Luzardo-Álvarez; Iván Lamela-Gómez; Francisco Otero-Espinar; José Blanco-Méndez. "Development, Characterization, and In Vitro Evaluation of Resveratrol-Loaded Poly-(e-caprolactone) Microcapsules Prepared by Ultrasonic Atomization for Intra-Articular Administration". Pharmaceutics 11 6 (2019): 249-249. https://doi.org/10.3390/pharmaceutics11060249.
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  57. Zulema Vargas-Osorio; Asteria Luzardo-Álvarez; Yolanda Piñeiro; Carlos Vázquez-Vázquez; J. Luis Gómez-Amoza; José Blanco-Méndez; Francisco J. Otero Espinar; José Rivas. "Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility". ACS Omega (2019): https://doi.org/10.1021/acsomega.8b03676.
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  58. Mariño-López, A.; Sousa-Castillo, A.; Carbó-Argibay, E.; Otero-Espinar, F.; Alvarez-Puebla, R.A.; Pérez-Lorenzo, M.; Correa-Duarte, M.A.. "Laser-protective soft contact lenses: Keeping an eye on the eye through plasmonics". Applied Materials Today 15 (2019): 1-5. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059304572&partnerID=MN8TOARS.
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  60. Seoane-Viaño, I.; Gómez-Lado, N.; Lázare-Iglesias, H.; Rey-Bretal, D.; Lamela-Gómez, I.; Otero-Espinar, F.J.; Blanco-Méndez, J.; et al. "Evaluation of the therapeutic activity of melatonin and resveratrol in Inflammatory Bowel Disease: A longitudinal PET/CT study in an animal model". International Journal of Pharmaceutics 572 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073689176&partnerID=MN8TOARS.
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  61. Romero, V.; Lara, J.R.; Otero-Espinar, F.; Salgado, M.H.; Modolo, N.S.P.; Barros, G.A.M.D.. "Capsaicin topical cream (8%) for the treatment of myofascial pain syndrome,Creme tópico de capsaicina (8%) para o tratamento da síndrome da dor miofascial". Brazilian Journal of Anesthesiology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071985370&partnerID=MN8TOARS.
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  62. Martínez-Casal, X.; Rodriguez-Sánchez, J.L.; Otero-Espinar, F.J.. "Budget impact analysis of two pharmaceutical management models in relation to the administration of intravenous anti-infective therapy in a Spanish nursing home". European Journal of Hospital Pharmacy (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071447341&partnerID=MN8TOARS.
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  63. Espinar, Francisco. "Ocular Biodistribution Studies Using Molecular Imaging". Pharmaceutics (2019): https://www.mdpi.com/1999-4923/11/5/237.
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  64. Barbara S. Gregorí Valdes; Ana Paula Serro; Joana Marto; Rui Galhano dos Santos; Elena Cutrín Gómez; Francisco Javier Otero Espinar; João Moura Bordado; Helena Ribeiro. "Polyurethanes as New Excipients in Nail Therapeutics". Pharmaceutics (2018): http://www.mdpi.com/1999-4923/10/4/276.
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  65. Elena Cutrín-Gómez; Soledad Anguiano-Igea; Given Names Deactivated Family Name Deactivated; Jose Luis Gomez-Amoza; Francisco Javier Otero Espinar. "Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers". Pharmaceutics (2018): http://www.mdpi.com/1999-4923/10/4/273.
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  66. Carlos Fernandes; Cláudia Martins; André Fonseca; Rute Nunes; Maria João Matos; Renata Silva; Jorge Garrido; et al. "PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor". ACS Applied Materials & Interfaces (2018): https://doi.org/10.1021/acsami.8b17224.
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  67. Elena Cutrín-Gómez; Soledad Anguiano-Igea; Given Names Deactivated Family Name Deactivated; Jose Luis Gomez-Amoza; Francisco Javier Otero Espinar. "Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer". Pharmaceutics (2018): http://www.mdpi.com/1999-4923/10/3/156.
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  68. Seoane-Viaño I; Gómez-Lado N; Lázare-Iglesias H; Barreiro-de Acosta M; Silva-Rodríguez J; Luzardo-Álvarez A; Herranz M; Otero-Espinar F; Ruibal Á. "Longitudinal PET/CT evaluation of TNBS-induced inflammatory bowel disease rat model.". International journal of pharmaceutics (2018): http://europepmc.org/abstract/med/30081226.
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  70. Espinar, Francisco. "Review of Intraocular Pharmacokinetics of Anti-Infectives Commonly Used in the Treatment of Infectious Endophthalmitis". Pharmaceutics (2018): http://www.mdpi.com/1999-4923/10/2/66.
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  71. Victoria Díaz-Tomé; Andrea Luaces-Rodríguez; Jesús Silva-Rodríguez; Sara Blanco-Dorado; Laura García-Quintanilla; José Llovo-Taboada; José Blanco-Méndez; et al. "Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis". Journal of Pharmaceutical Sciences 107 5 (2018): 1342-1351. https://doi.org/10.1016%2Fj.xphs.2017.12.028.
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  72. Elena Cutrín Gómez; Soledad Anguiano Igea; José Luis Gómez Amoza; Francisco J. Otero Espinar. "Evaluation of the promoting effect of soluble cyclodextrins in drug nail penetration". European Journal of Pharmaceutical Sciences 117 (2018): 270-278. https://doi.org/10.1016/j.ejps.2018.02.028.
    10.1016/j.ejps.2018.02.028
  73. Elena Cutrín Gómez; Soledad Anguiano Igea; M. Begoña Delgado-Charro; José Luis Gómez Amoza; Francisco J. Otero Espinar. "Microstructural alterations in the onychomycotic and psoriatic nail: relevance in drug delivery". European Journal of Pharmaceutics and Biopharmaceutics (2018): https://doi.org/10.1016/j.ejpb.2018.04.012.
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  74. Espinar, Francisco. "Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis". Journal of Pharmaceutical Sciences 107 5 (2018): 1342-1351. http://www.sciencedirect.com/science/article/pii/S0022354917309103.
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  75. Espinar, Francisco. "Preclinical characterization and clinical evaluation of tacrolimus eye drops". European Journal of Pharmaceutical Sciences 120 (2018): 152-161. http://www.sciencedirect.com/science/article/pii/S0928098718302033.
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  76. Fernández-Ferreiro A; Luaces-Rodríguez A; Díaz-Tomé V; Gil-Martínez M; Rodríguez Ares MT; Touriño Peralba R; Blanco-Méndez J; González-Barcia M; Lamas MJ. "[Cysteamine ophthalmic hydrogel for the treatment of ocular cystinosis].". Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria (2017): http://europepmc.org/abstract/med/29112493.
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  77. Elena Villar López; Asteria Luzardo Álvarez; José Blanco Méndez; Francisco J. Otero Espinar. "Cellulose-polysaccharide film-coating of cyclodextrin based pellets for controlled drug release". Journal of Drug Delivery Science and Technology (2017): https://doi.org/10.1016%2Fj.jddst.2017.03.031.
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  78. Eva García-Millán; Mónica Quintáns-Carballo; Francisco Javier Otero-Espinar. "Improved release of triamcinolone acetonide from medicated soft contact lenses loaded with drug nanosuspensions". International Journal of Pharmaceutics (2017): https://doi.org/10.1016%2Fj.ijpharm.2017.03.082.
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  80. García-Millán, E.; Quintáns-Carballo, M.; Otero-Espinar, F.J.. "Solid-state characterization of triamcinolone acetonide nanosuspensiones by X-ray spectroscopy, ATR Fourier transforms infrared spectroscopy and differential scanning calorimetry analysis". Data in Brief 15 (2017): 133-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029928365&partnerID=MN8TOARS.
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  81. de Ocenda, V.-R.; Almeida-Prieto, S.; Luzardo-Álvarez, A.; Barja, J.L.; Otero-Espinar, F.J.; Blanco-Méndez, J.. "Pharmacokinetic model of florfenicol in turbot (Scophthalmus maximus): establishment of optimal dosage and administration in medicated feed". Journal of Fish Diseases 40 3 (2017): 411-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994631737&partnerID=MN8TOARS.
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  82. Fernández-Ferreiro, A.; Silva-Rodríguez, J.; Otero-Espinar, F.J.; González-Barcia, M.; Lamas, M.J.; Ruibal, A.; Luaces-Rodriguez, A.; et al. "Positron emission tomography for the development and characterization of corneal permanence of ophthalmic pharmaceutical formulations". Investigative Ophthalmology and Visual Science 58 2 (2017): 772-780. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011580007&partnerID=MN8TOARS.
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  83. Fernández-Ferreiro, A.; Silva-Rodríguez, J.; Otero-Espinar, F.J.; González-Barcia, M.; Lamas, M.J.; Ruibal, A.; Luaces-Rodríguez, A.; et al. "In vivo eye surface residence determination by high-resolution scintigraphy of a novel ion-sensitive hydrogel based on gellan gum and kappa-carrageenan". European Journal of Pharmaceutics and Biopharmaceutics 114 (2017): 317-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013213067&partnerID=MN8TOARS.
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  84. Blanco-García, E.; Otero-Espinar, F.J.; Blanco-Méndez, J.; Leiro-Vidal, J.M.; Luzardo-Álvarez, A.. "Development and characterization of anti-inflammatory activity of curcumin-loaded biodegradable microspheres with potential use in intestinal inflammatory disorders". International Journal of Pharmaceutics 518 1-2 (2017): 86-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007570696&partnerID=MN8TOARS.
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  87. Méndez, S.G.; Otero Espinar, F.J.; Alvarez, A.L.; Longhi, M.R.; Quevedo, M.A.; Zoppi, A.. "Ternary complexation of benzoic acid with ß-cyclodextrin and aminoacids. Experimental and theoretical studies". Journal of Inclusion Phenomena and Macrocyclic Chemistry 85 1-2 (2016): 33-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965170034&partnerID=MN8TOARS.
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  95. Fernandez-Ferreiro, A; Gonzalez Barcia, M; Gil Martinez, M; Blanco Mendez, J; Lamas Diaz, M J; Otero Espinar, F J. "[Analysis of ocular toxicity of fluconazole and voriconazole eyedrops using HET-CAM].". Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 38 4 (2014): 300-4.
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  96. Espinar, Francisco. "Cyclodextrin based rotaxanes, polyrotaxanes and polypseudorotaxanes and their biomedical applications.". Current Topics in Medicinal Chemistry (2014): http://europepmc.org/abstract/med/24354671.
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  99. Fernández-Ferreiro, A.; Bargiela, N.F.; Varela, M.S.; Martínez, M.G.; Pardo, M.; Ces, A.P.; Méndez, J.B.; et al. "Cyclodextrin-polysaccharide-based, in situ-gelled system for ocular antifungal delivery". Beilstein Journal of Organic Chemistry 10 (2014): 2903-2911. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920083379&partnerID=MN8TOARS.
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  100. Campaña-Seoane, M.; Peleteiro, A.; Laguna, R.; Otero-Espinar, F.J.. "Bioadhesive emulsions for control release of progesterone resistant to vaginal fluids clearance". International Journal of Pharmaceutics 477 1-2 (2014): 495-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-84910030490&partnerID=MN8TOARS.
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  103. Nogueiras-Nieto, Luis; Delgado-Charro, M. Begona; Otero-Espinar, Francisco J.. "Thermogelling hydrogels of cyclodextrin/poloxamer polypseudorotaxanes as aqueous-based nail lacquers: Application to the delivery of triamcinolone acetonide and ciclopirox olamine". European Journal of Pharmaceutics and Biopharmaceutics 83 3 (2013): 370-377.
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  104. Espinar, Francisco. "Use of 1H NMR STD, WaterLOGSY, and Langmuir monolayer techniques for characterization of drug-zein protein complexes". European Journal of Pharmaceutics and Biopharmaceutics 85 3 PART A (2013): 790-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888381697&partnerID=MN8TOARS.
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  105. Ruiz-Caro R; Gago-Guillan M; Otero-Espinar FJ; Veiga MD. "Mucoadhesive tablets for controlled release of acyclovir.". Chemical & pharmaceutical bulletin (2012): http://europepmc.org/abstract/med/22863800.
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  106. Nogueiras-Nieto, Luis; Sobarzo-Sanchez, Eduardo; Luis Gomez-Amoza, Jose; Otero-Espinar, Francisco J.. "Competitive displacement of drugs from cyclodextrin inclusion complex by polypseudorotaxane formation with poloxamer: Implications in drug solubilization and delivery". European Journal of Pharmaceutics and Biopharmaceutics 80 3 (2012): 585-595.
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  107. Folch-Cano, Christian; Olea-Azar, Claudio; Sobarzo-Sanchez, Eduardo; Alvarez-Lorenzo, Carmen; Concheiro, Angel; Otero, Francisco; Jullian, Carolina. "Inclusion Complex of 4-Hydroxycoumarin with Cyclodextrins and Its Characterization in Aqueous Solution". Journal of Solution Chemistry 40 11 (2011): 1835-1846.
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  109. Alvarez AL; Espinar FO; Méndez JB. "The application of microencapsulation techniques in the treatment of endodontic and periodontal diseases.". (2011): http://europepmc.org/abstract/med/24310596.
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  110. Luzardo-Alvarez, A.; Otero-Espinar, F.J.; Blanco-Méndez, J.. "Microencapsulation of diets and vaccines for cultured fishes, crustaceans and bivalve mollusks". Journal of Drug Delivery Science and Technology 20 4 (2010): 277-288. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149376361&partnerID=MN8TOARS.
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  119. Nogueiras-Nieto, Luis; Alvarez-Lorenzo, Carmen; Sandez-Macho, Isabel; Concheiro, Angel; Otero-Espinar, Francisco J.. "Hydrosoluble Cyclodextrin/Poloxamer Polypseudorotaxanes at the Air/Water Interface, in Bulk Solution, and in the Gel State". Journal of Physical Chemistry B 113 9 (2009): 2773-2782.
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  120. Sergio, Almeida-Prieto; Cristiana Isabel, de Sa Ferreira da Rocha; Jose, Blanco-Mendez; Otero-Espinar, Francisco J.. "Fast and controlled release of triamcinolone acetonide from extrusion-spheronization pellets based on mixtures of native starch with dextrin or waxy maize starch". Drug Development and Industrial Pharmacy 33 9 (2007): 945-951.
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  121. Almeida-Prieto, Sergio; Blanco-Mendez, Jose; Otero-Espinar, Francisco J.. "Microscopic image analysis techniques for the morphological characterization of pharmaceutical particles: Influence of the software, and the factor algorithms used in the shape factor estimation". European Journal of Pharmaceutics and Biopharmaceutics 67 3 (2007): 766-776.
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  123. Siemoneit, U; Schmitt, C; Alvarez-Lorenzo, C; Luzardo, A; Otero-Espinar, F; Concheiro, A; Blanco-Mendez, J. "Acrylic/cyclodextrin hydrogels with enhanced drug loading and sustained release capability". International Journal of Pharmaceutics 312 1-2 (2006): 66-74.
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  124. Luzardo-Alvarez, A.; Almeida-Prieto, S.; Fraga-Lopez, F.; Otero-Espinar, F.; Rodriguez-Nunez, E.; Martinez-Ageitos, J.; Blanco-Mendez, J.. "Effect of formulation variables on the prediction of release from microparticles with experimental design". Journal of Applied Polymer Science 102 5 (2006): 4546-4553.
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  126. Castro-Hermida, JA; Gomez-Couso, H; Ares-Mazas, ME; Gonzalez-Edia, MM; Castaneda-Cancio, N; Otero-Espinar, FJ; Blanco-Mendez, J. "Anticryptosporidial activity of furan derivative G1 and its inclusion complex with beta-cyclodextrin". Journal of Pharmaceutical Sciences 93 1 (2004): 197-206.
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  129. A Luzardo-Álvarez; J Marti´nez-Mazagatos; M.T Santamarina-Fernández; F.J Otero-Espinar; J Blanco-Méndez. "Oral pharmacological treatments for ichthyophthiriosis of rainbow trout (Oncorhynchus mykiss)". Aquaculture 220 1-4 (2003): 15-25. https://doi.org/10.1016%2Fs0044-8486%2802%2900228-4.
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  176. Vila Jato, J.L.; Blanco Mendez, J.; Anguiano Igea, S.; Otero Es inar, F.J.; Fernandez Souto, J.; Torres Labandeira, J.J.. "Inclusion compounds with cyclodextrins. Part II: Preparation and methods of study,COMPUESTOS DE INCLUSION CON CICLODEXTRINAS. PARTE II: PREPARACION Y METODOS DE ESTUDIO". Farmacia Hospitalaria 14 1 (1990): 35-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024986412&partnerID=MN8TOARS.
Capítulo de livro
  1. Seoane-Viaño, I.; Otero-Espinar, F.J.; Goyanes, Á.. "3D printing of pharmaceutical products". 569-597. 2021.
  2. Díaz-Tome, V.; Ares, M.T.-R.; Varela-Fernández, R.; Touriño-Peralba, R.; González-Barcia, M.; Martínez-Pérez, L.; Lamas, M.J.; Otero-Espinar, F.J.; Fernández-Ferreiro, A.. "Therapeutic approach in fungal keratitis". 189-216. 2019.
Livro
  1. Otero-Espinar, F.J.; Fernández-Ferreiro, A.; González-Barcia, M.; Blanco-Méndez, J.; Luzardo, A.. Stimuli sensitive ocular drug delivery systems. 2018.
Pré-impressão
  1. J. Victor Alvarez; Susana B Bravo; Maria del Pilar Chantada-Vázquez; Carmen Pena; Cristóbal Colón; Shunji Tomatsu; Francisco J. Otero-Espinar; MARIA LUZ COUCE. "Morquio a Syndrome: Identification of Differential Patterns of Molecular Pathway Interac-Tions in Bone Lesions". 2024. https://doi.org/10.20944/preprints202401.2246.v1.
    10.20944/preprints202401.2246.v1

Outros

Outra produção
  1. Stimuli sensitive ocular drug delivery systems. 2018. Francisco J. Otero-Espinar; Anxo Fernández-Ferreiro; Miguel González-Barcia; José Blanco-Méndez; Asteria Luzardo. https://doi.org/10.1016%2Fb978-0-12-813689-8.00006-9.
    10.1016/b978-0-12-813689-8.00006-9
  2. Preparation by Extrusion/Spheronization of Triamcinolone / ß-Cyclodextrin Pellets as a Fast Release Dosage Form. 1999. M. E. Villar-López; F. Otero-Espinar; J. Blanco-Méndez. https://doi.org/10.1007%2F978-94-011-4681-4_115.
    10.1007/978-94-011-4681-4_115
  3. Study of Inclusion Compound of Triamcinolone Acetonide. 1999. M. E. Villar-López; L. Nieto-Reyes; F. Otero-Espinar; J. Blanco-Méndez. https://doi.org/10.1007%2F978-94-011-4681-4_99.
    10.1007/978-94-011-4681-4_99