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Flávia Castro is currently Junior Researcher and Project leader at the Instituto de Investigação e Inovação em Saúde (i3S), University of Porto. Flávia was recently awarded by the Portuguese Government fund "Stimulus of Scientific Employment, Individual Support 2021 (CEECIND)" to pursuit her research towards independence at i3S in Portugal (ranked the 1st place in the Medical Engineering and Biotechnology Panel) in the potential of breast cancer-immune crosstalk by extracellular vesicles towards immunotherapy. She is currently a PI of a project funded by FCT (RADIORESISTANCE, 250K€) to investigate the immune-mediated mechanisms involved in breast cancer radioresistance, with focus on the development of new therapies. She co-supervises 3 PhD students. Flávia developed her international PhD studies in new biomaterials-based immunotherapies for cancer treatment. She started her PhD in 2015 at Prof Maria Oliveira lab at i3S (Porto, Portugal), which expertise allowed the development of unique immunomodulatory tool to reprogram tumor microenvironment. In 2017 she joined for almost 1 year Prof Olivier de Wever´s Lab, one of the most renown groups in Cancer Research, at Ghent University Hospital (Belgium). This technology was highlighted in the media (printed press), inspired an FCT-funded project - MAGICIAM (PTDC/BTM-SAL/31859/2017,250K€) in which she was team member, 6 publications (citations: 875, Scopus), 17 oral and 19 poster presentations as 1st author, 1MSc project co-supervised by her, and 2 publications as co-last author. This work was recognized by the scientific community, through 12 distinct awards/distinctions, including Julia Polak European Doctoral Thesis Award 2020 and Best Student Award 2019, both by European Society of Biomaterials (ESB), 3 travel grants to participate in highly recognized international meetings by European Association for Cancer Research (EACR), and 2 travel grants by European Commission sponsored COST Missions and by Portuguese Society of Immunology (SPI) to pursuit her PhD studies at Ghent University, in Belgium. Also, she was awarded with 2 best poster presentation prizes in national/international meetings, one by Liga Portuguesa Contra o Cancro (LPCC). In the end of 2019, she started a Post-Doctoral position at Nanomedicines & Translational Drug Delivery Group, led by Prof Bruno Sarmento, at i3S and was responsible for a FCT-funded project (PTDC/BTM-SAL/30034/2017) to evaluate cancer nanomedicines in in vivo models. She published 1st authored 4 additional publications at high-impact J Control Release and Adv Drug Deliv Rev and co-authored a Nature Methods publication in an international consortium. Overall, she has a h-hindex of 14, cumulative impact factor of 121 and a total of 1250 citations (Scopus). She interacted with more than 146 authors (+7 nationalities), publishing in total 23 articles, 4 conference proceedings, 2 book chapters, and participated in one patent 1 patent (PCT/PT2021/050025). Flávia gave invited seminars, lectures and presented her work at several national/international meetings (21 oral communications and 20 posters, as 1st author). In 2021, she was awarded with best oral communication by Liga Portuguesa Contra o Cancro (LPCC) and in 2022 with 1st Raquel Seruca Award at ASPIC meeting. In 2023, she did a Short-Term Scientific Mission granted by COST at Prof Alfonso Calvo's Lab, at CIMA, University of Navarra. Alongside her research activities, Flávia had been part of the team of 6 FCT-funded projects and 1 national consortium (4M€). She had also actively mentoring and supervising 1 Post-Doc, 6 PhDs and 8 MSc students. Flávia is invited peer-reviewed for several journals, as ACS Nano and Frontiers in Immunol. She has been also Invited Lecturer at CESPU, FMUP and ICBAS. She has participated in several outreach activities, such as general public/schools science dissemination. She is Ambassador of EACR, and was nominee as one of the 2020 University of Porto personalities.
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Identificação

Identificação pessoal

Nome completo
Flávia Raquel Teixeira de Castro

Nomes de citação

  • Castro, Flávia

Identificadores de autor

Ciência ID
7512-80CF-2A6B
ORCID iD
0000-0002-2273-2806
Google Scholar ID
https://scholar.google.pt/citations?user=nUhaykEAAAAJ&hl=pt-PT
Scopus Author Id
56677356800

Endereços de correio eletrónico

  • flaviateixeiracastro@ineb.up.pt (Profissional)

Telefones

Telefone
  • 22 607 49 Ext.: 6106 (Profissional)

Moradas

  • i3S- Instituto de Investigação e Inovação em Saúde, 4200-135, Rua Alfredo Allen, 208, Porto, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica - Oncologia
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências da Engenharia e Tecnologias - Nanotecnologia
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2021/07/09 - 2021/07/27
Concluído
 Leadership and Team Management (Outros)
Instituto do Emprego e Formação Profissional, Portugal
2015/01/02 - 2019/07/11
Concluído
 Cellular and Molecular Biotechnology Applied to Health Sciences (Doutoramento)
Especialização em Tumor Microenvironment and Immunotherapy
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Targeting antigen-presenting cells: chitosan/poly(¿-glutamic acid) nanoparticles as adjuvants to anticancer therapy" (TESE/DISSERTAÇÃO)
 Aprovado
2017
Concluído
 SIICA School of Immunology - Advanced Course (Bari, Italy) (Outros)
Especialização em University of Bari, Italy
Italian Society of Immunology, Clinical Immunology & Allergology, Itália
2016
Concluído
 Hands-on workshop on Image Analysis for Imaging flow Cytometry (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/10
Concluído
 Course in Laboratory Animal Science accredited by FELASA, Category C (Outros)
Instituto Nacional de Engenharia Biomédica, Portugal
2015
Concluído
 V Workshop on Cancer Research (Outros)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2015
Concluído
 Advanced Summer School Interrogations at the Biointerface: The Nano/Medicine interface (Outros)
Instituto Nacional de Engenharia Biomédica, Portugal
2012/09/06 - 2014/06/21
Concluído
 Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"Impact of IL-10 and Sirtuin2 in the protective immune response to Mycobacterium tuberculosis and Listeria monocytogenes infections" (TESE/DISSERTAÇÃO)
 17 valores
2009/09/10 - 2012/07/31
Concluído
 Biochemistry (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
"Common and distinct pathways triggered in macrophages upon recognition of Mycobacterium tuberculosis strains" (TESE/DISSERTAÇÃO)
 16 valores
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/03/31 - Atual Investigador Contratado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/12/01 - 2021/05/31 Investigador Contratado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/08/01 - 2019/11/30 Investigador (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/02/01 - 2019/07/31 PhD student at Dr Maria José Oliveira Lab (i3S, Porto), supported with a Research fellowship (POCI-01-0145-FEDER-016390) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/12/01 - 2018/12/31 Visiting PhD student at Dr Olivier de Wever Lab (Ghent, Belgium) and at Dr Bruno Silva Santos Lab (IMM, Lisbon), supported with a FCT scholarship PD/BD/114013/2015 Universiteit Gent, Bélgica
Universiteit Gent, Bélgica
(...)
2015/01/01 - 2017/11/30 PhD student at Dr Maria José Oliveira Lab (i3S, Porto), supported with a FCT scholarship PD/BD/114013/2015 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Projetos

Bolsa

Designação Financiadores
2023/01 - Atual FibroSkin - Desvendar mediadores biomecânicos em fibrose de pele para o desenvolvimento de um novo modelo 3D biomimético
2022.06048.PTDC
Investigador
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Em curso
2023 - Atual REVERENT: validação pré-clínica de uma vacina inspirada no código glicosídico das células tumorais para imunoterapia em cancro de bexiga
2022.03621.PTDC
Investigador
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
Em curso
2022/01/01 - Atual RADIORESISTANCE - Dissect the tumor microenvironment to battle cancer radioresistance and immune escape
PTDC/MED-ONC/4165/2021
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2022 - Atual RESOLVE: Rational Design of Multivalent Glycocode-Inspired Nanovaccines for Gastric Cancer Immunotherapy
PTDC/MED-OUT/2512/2021
Investigador
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
2022/01/01 - 2024/12/31 Dissect the tumor microenvironment to battle cancer radioresistance and immune escape
PTDC/MED-ONC/4165/2021
10.54499/PTDC/MED-ONC/4165/2021
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade NOVA de Lisboa, Portugal

Fundação Champalimaud, Portugal

Centro Hospitalar Universitário de São João, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/01/01 - 2021/12/29 MAGICIAM-a MAcrophaGe Immunomodulatory-delivery system to prevent Cancer Invasion And Metastasis
POCI-01-0145-FEDER-031859
Bolseiro de Doutoramento
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/02/01 - 2019/11/30 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
POCI-01-0145-FEDER-016390
Bolseiro de Investigação
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2015/01/02 - 2018/12/31 Development of an immunomodulatory delivery system to prevent cancer cell invasion and metastasis.
PD/BD/114013/2015
Bolseiro de Doutoramento
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2017/12 - 2018/02 Short-Term Mission Action from COST: The effect of immunomodulatory nanoparticles on macrophage cytoskeleton dynamics and their impact on cancer cell invasion
CA15214 - 38043
Bolseiro de Doutoramento
Universiteit Gent, Bélgica
 European Cooperation in Science and Technology
Concluído

Projeto

Designação Financiadores
2022/07/01 - 2028/06/30 HI-DEFENCE: engineering HybrID Exosomes For brEast caNcer VacCinE
2021.01773.CEECIND/CP1663/CT0007
10.54499/2021.01773.CEECIND/CP1663/CT0007
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/12/01 - 2021/02/28 Cell penetrating p28 peptide-mediated delivery of nanomedicines for cancer treatment
POCI-01-0145-FEDER-030034
Investigador
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto Politécnico de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Ferreira, Eduardo; Gaiteiro, Cristiana; et al. "A Multivalent CD44 Glycoconjugate Vaccine Candidate for Cancer Immunotherapy". Journal of Controlled Release (2024):
    Aceite para publicação
  2. Silveira, Maria José; Martins, Cláudia; Cruz, Tânia; Castro, Flávia; Amorim-Costa, Ângela; Chester, Kerry; Oliveira, Maria José; Sarmento, Bruno. "scFv biofunctionalized nanoparticles to effective and safe targeting of CEA-expressing colorectal cancer cells". Journal of Nanobiotechnology 21 1 (2023): http://dx.doi.org/10.1186/s12951-023-02126-4.
    10.1186/s12951-023-02126-4
  3. Domingues, Mariana; Pereira, Catarina Leite; Sarmento, Bruno; Castro, Flávia. "Mimicking 3D breast tumor-stromal interactions to screen novel cancer therapeutics". European Journal of Pharmaceutical Sciences (2023): 106560. http://dx.doi.org/10.1016/j.ejps.2023.106560.
    Acesso aberto • No prelo • 10.1016/j.ejps.2023.106560
  4. Nascimento, Camila; Castro, Flávia; Domingues, Mariana; Lage, Anna; Alves, Érica; de Oliveira, Rodrigo; de Melo, Celso; Eduardo Calzavara-Silva, Carlos; Sarmento, Bruno. "Reprogramming of tumor-associated macrophages by polyaniline-coated iron oxide nanoparticles applied to treatment of breast cancer". International Journal of Pharmaceutics 636 (2023): 122866. http://dx.doi.org/10.1016/j.ijpharm.2023.122866.
    10.1016/j.ijpharm.2023.122866
  5. Torres Quintas, Sofia; Canha-Borges, Ana; Oliveira, Maria José; Sarmento, Bruno; Castro, Flávia. "Special Issue: Nanotherapeutics in Women's Health Emerging Nanotechnologies for Triple-Negative Breast Cancer Treatment". Small (2023): http://dx.doi.org/10.1002/smll.202300666.
    Publicado • 10.1002/smll.202300666
  6. Pinto, Ana Teresa; Machado, Ana Beatriz; Osório, Hugo; Pinto, Marta Laranjeiro; Vitorino, Rui; Justino, Gonçalo; Santa, Cátia; et al. "Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression". Cancers 15 1 (2022): 270. http://dx.doi.org/10.3390/cancers15010270.
    Publicado • 10.3390/cancers15010270
  7. Almeida, Andreia; Castro, Flávia; Resende, Carlos; Lúcio, Marlene; Schwartz, Simó; Sarmento, Bruno. "Oral delivery of camptothecin-loaded multifunctional chitosan-based micelles is effective in reduce colorectal cancer". Journal of Controlled Release 349 (2022): 731-743. http://dx.doi.org/10.1016/j.jconrel.2022.07.029.
    Publicado • 10.1016/j.jconrel.2022.07.029
  8. V. Lima, Beatriz; Oliveira, Maria J.; Barbosa, Mário A.; Gonçalves, Raquel M.; Castro, Flávia. "Harnessing chitosan and poly-(y-glutamic acid)-based biomaterials towards cancer immunotherapy". Materials Today Advances 15 (2022): 100252. http://dx.doi.org/10.1016/j.mtadv.2022.100252.
    10.1016/j.mtadv.2022.100252
  9. Peirsman, Arne; Blondeel, Eva; Ahmed, Tasdiq; Anckaert, Jasper; Audenaert, Dominique; Boterberg, Tom; Buzas, Krisztina; et al. "MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity". Nature Methods (2021): http://dx.doi.org/10.1038/s41592-021-01291-4.
    Aceite para publicação • 10.1038/s41592-021-01291-4
  10. Garizo, Ana Rita; Castro, Flávia; Martins, Cláudia; Almeida, Andreia; Dias, Tiago P.; Fernardes, Fábio; Barrias, Cristina C.; et al. "p28-functionalized PLGA nanoparticles loaded with gefitinib reduce tumor burden and metastases formation on lung cancer". Journal of Controlled Release 337 (2021): 329-342. http://dx.doi.org/10.1016/j.jconrel.2021.07.035.
    Publicado • 10.1016/j.jconrel.2021.07.035
  11. Castro, Flávia; Leite Pereira, Catarina; Helena Macedo, Maria; Almeida, Andreia; José Silveira, Maria; Dias, Sofia; Patrícia Cardoso, Ana; José Oliveira, Maria; Sarmento, Bruno. "Advances on colorectal cancer 3D models: The needed translational technology for nanomedicine screening". Advanced Drug Delivery Reviews 175 (2021): 113824. http://dx.doi.org/10.1016/j.addr.2021.06.001.
    10.1016/j.addr.2021.06.001
  12. Castro, Flávia; Martins, Cláudia; Silveira, Maria José; Moura, Rui Pedro; Pereira, Catarina Leite; Sarmento, Bruno. "Advances on erythrocyte-mimicking nanovehicles to overcome barriers in biological microenvironments". Advanced Drug Delivery Reviews 170 (2021): 312-339. http://dx.doi.org/10.1016/j.addr.2020.09.001.
    Publicado • 10.1016/j.addr.2020.09.001
  13. Cardoso, Ana Patrícia; Pinto, Marta Laranjeiro; Castro, Flávia; Costa, Ângela Margarida; Marques-Magalhães, Ângela; Canha-Borges, Ana; Cruz, Tânia; Velho, Sérgia; Oliveira, Maria José. "THE IMMUNOSUPPRESSIVE AND PRO-TUMOR FUNCTIONS OF CCL18 AT THE TUMOR MICROENVIRONMENT". Cytokine & Growth Factor Reviews (2021): http://dx.doi.org/10.1016/j.cytogfr.2021.03.005.
    Publicado • 10.1016/j.cytogfr.2021.03.005
  14. Silveira, Maria José; Castro, Flávia; Oliveira, Maria José; Sarmento, Bruno. "Immunomodulatory nanomedicine for colorectal cancer treatment: a landscape to be explored?". Biomaterials Science 9 9 (2021): 3228-3243. http://dx.doi.org/10.1039/d1bm00137j.
    Publicado • 10.1039/d1bm00137j
  15. Lima, Beatriz V.; Oliveira, Maria J.; Barbosa, Mário A.; Gonçalves, Raquel M.; Castro, Flávia. "Immunomodulatory potential of chitosan-based materials for cancer therapy: a systematic review of in vitro, in vivo and clinical studies". Biomaterials Science 9 9 (2021): 3209-3227. http://dx.doi.org/10.1039/d0bm01984d.
    Publicado • 10.1039/d0bm01984d
  16. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina L.; Serre, Karine; Barbosa, Mário A.; Vermaelen, Karim; Gärtner, Fátima; et al. "Chitosan/y-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer". Biomaterials (2020): 120218. http://dx.doi.org/10.1016/j.biomaterials.2020.120218.
    Publicado • 10.1016/j.biomaterials.2020.120218
  17. Martins, Flávia; Oliveira, Rosa; Cavadas, Bruno; Pinto, Filipe; Cardoso, Ana Patrícia; Castro, Flávia; Sousa, Bárbara; et al. "Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer". Cancers 12 4 (2020): 818. http://dx.doi.org/10.3390/cancers12040818.
    Publicado • 10.3390/cancers12040818
  18. Castro, Flávia; Pinto, Marta Laranjeiro; Almeida, Rui; Pereira, Flávia; Silva, Andreia Machado; Pereira, Catarina Leite; Santos, Susana Gomes; et al. "Chitosan/poly(y-glutamic acid) nanoparticles incorporating IFN-y for immune response modulation in the context of colorectal cancer". Biomaterials Science 7 8 (2019): 3386-3403. http://dx.doi.org/10.1039/c9bm00393b.
    Publicado • 10.1039/c9bm00393b
  19. Castro, Flávia; Cardoso, Ana Patrícia; Gonçalves, Raquel Madeira; Serre, Karine; Oliveira, Maria José. "Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion". Frontiers in Immunology 9 (2018): http://dx.doi.org/10.3389/fimmu.2018.00847.
    Publicado • 10.3389/fimmu.2018.00847
  20. Castro, Flávia; Pinto, Marta L.; Silva, Andreia M.; Pereira, Catarina L.; Teixeira, Graciosa Q.; Gomez-Lazaro, Maria; Santos, Susana G.; et al. "Pro-inflammatory chitosan/poly(y-glutamic acid) nanoparticles modulate human antigen-presenting cells phenotype and revert their pro-invasive capacity". Acta Biomaterialia 63 (2017): 96-109. http://dx.doi.org/10.1016/j.actbio.2017.09.016.
    Publicado • 10.1016/j.actbio.2017.09.016
  21. Moreira-Teixeira, Lúcia; Sousa, Jeremy; McNab, Finlay W.; Torrado, Egídio; Cardoso, Filipa; Machado, Henrique; Castro, Flávia; et al. "Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-y Signaling". The Journal of Immunology 197 12 (2016): 4714-4726. http://dx.doi.org/10.4049/jimmunol.1600584.
    Publicado • 10.4049/jimmunol.1600584
  22. Teixeira, Graciosa Q.; Leite Pereira, Catarina; Castro, Flávia; Ferreira, Joana R.; Gomez-Lazaro, Maria; Aguiar, Paulo; Barbosa, Mário A.; Neidlinger-Wilke, Cornelia; Goncalves, Raquel M.. "Anti-inflammatory Chitosan/Poly-y-glutamic acid nanoparticles control inflammation while remodeling extracellular matrix in degenerated intervertebral disc". Acta Biomaterialia 42 (2016): 168-179. http://dx.doi.org/10.1016/j.actbio.2016.06.013.
    Publicado • 10.1016/j.actbio.2016.06.013
  23. Cardoso, Ana Patricia; Gonçalves, Raquel Madeira; Antunes, Joana C.; Pinto, Marta Laranjeiro; Pinto, Ana Teixeira; Castro, Flávia; Monteiro, Cátia; Barbosa, Mário Adolfo; Oliveira, Maria José. "An interferon-y-delivery system based on chitosan/poly(y-glutamic acid) polyelectrolyte complexes modulates macrophage-derived stimulation of cancer cell invasion in vitro". Acta Biomaterialia 23 (2015): 157-171. http://dx.doi.org/10.1016/j.actbio.2015.05.022.
    Publicado • 10.1016/j.actbio.2015.05.022
  24. Castro, Flávia; Cardoso, Filipa; Moreira-Teixeira, Lúcia; Sousa, Jeremy; Torrado, Egídio; Silvestre, Ricardo; Castro, António Gil; Saraiva, Margarida; Pais, Teresa F.. "Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control". PLOS ONE 10 7 (2015): e0131904. http://dx.doi.org/10.1371/journal.pone.0131904.
    Publicado • 10.1371/journal.pone.0131904
Capítulo de livro
  1. Bebiano, Luís B; Castro, Flávia; Li, Yi-Chen Ethan; Pereira, Bruno; Pereira, Rúben F. "Bioprinting Biomimetic 3D Constructs for Tissue Modelling and Repair". In Emerging Drug Delivery and Biomedical Engineering Technologies. Taylor & Francis Group, 2023.
    Publicado
  2. Castro, Flávia; Sarmento, Bruno. "Targeted Photodynamic Immunotherapy". In Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, editado por Lara Milane; Mansoor Amiji, 463-481. Elsevier, 2022.
    Publicado
Poster em conferência
  1. Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Ferreira, Eduardo; Gaiteiro, Cristiana; et al. "Pre-clinical Validation of a Multivalent CD44 Glycoconjugate Vaccine for Cancer Immunotherapy". Trabalho apresentado em 1st Young Researcher's Day, 2023.
  2. Ferreira, Eduardo; Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Palmeira, Carlos; et al. "A Targeted and Self-Adjuvated PLGA MUC16-Tn Nanoglycovaccine Candidate for Cancer Immunotherapy". Trabalho apresentado em 1st Young Researcher's Day, 2023.
  3. Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Gaiteiro, Cristiana; Ferreira, Eduardo; Relvas-Santos, Marta; Soares, Janine; et al. "Production and pre-clinical evaluation of immunogenic CD44 glycoconjugates: setting the molecular bases for novel multivalent anti-cancer glycovaccines". Trabalho apresentado em Trabalho apresentado no XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  4. Ana Rita Santos; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Castro, Flávia; Luísa Pereira; Maria Jose Oliveira; Angela M Costa. "Hypoxia-driven immunomodulation at the colon cancer microenvironment". Trabalho apresentado em XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023.
  5. Magalhães, Maria Inês; Azevedo, M. J. ; Castro, Flávia; Maria José Oliveira; Angela M Costa; Sampaio-Maia, Benedita. ""Impact of maternal obesity on early-life microbiota-induced immune system priming - a preliminary study"". Trabalho apresentado em Dia Nacional do Laboratório de Microbiologia - Microrganismos na Saúde e na Doença (Faculdade de Farmácia da Universidade do Porto), 2022.
  6. Ferreira, Sara; Angela M Costa; Canão, Pedro Amoroso; Castro, Flávia; Carneiro, Fatima; Maria Jose Oliveira; Cardoso, Ana Patrícia. "The Role of the Extracellular Matrix on Cancer Stemness and Immunogenicity". Trabalho apresentado em 4th SICR-Symposium on Immunomodulation in Cancer & Regeneration, 2022.
  7. Miranda, Andreia; Ferreira, Dylan; Freitas, Rui; Relvas-Santos, Marta; Palmeira, Carlos; Paulo, Paula; Castro, Flávia; et al. "Cancer-associated short-chain O-GalNAc glycans induce an immunosupressive bladder cancer phenotype by impairing dendritic cells function. Trabalho apresentado no XLVII Annual Meeting of the Portuguese Society for Immunology.". Trabalho apresentado em XLVII Annual Meeting of the Portuguese Society for Immunology, 2022.
  8. Miranda, Andreia; Ferreira, Dylan; Freitas, Rui; Relvas-Santos, Marta; Palmeira, Carlos; Paulo, Paula; Castro, Flávia; et al. "Cancer-associated shor-chain O-GalNAc glycans induce an immunosupressive bladder cancer phenotype by impairing dendritic cells function. Trabalho apresentado no XLVII Annual Meeting of the Portuguese Society for Immunology.". Trabalho apresentado em XLVII Annual Meeting of the Portuguese Society for Immunology, 2022.
  9. Angela M Costa; Anas Rita Santos; Cardoso, Ana Patrícia; Flávia Couto Brandão Pereira; Castro, Flávia; Pereira, Luisa; Maria Jose Oliveira. "Unravel the hypoxia role on immunomodulation at the colon cancer microenvironment: a focus on macrophages.". Trabalho apresentado em HypoxEU 2022, 2022.
  10. Maria Inês Magalhães; Maria Joaão Azevedo; Castro, Flávia; Maria Jose Oliveira; Angela M Costa; Sampaio-Maia, Benedita. "Impact of maternal obesity in early-life microbiota immune system priming ¿ a preliminary study.". Trabalho apresentado em Microbiology Lab National Day- Pharmacy Faculty of Porto University, 2022.
  11. Mariana Miranda Domingues; Sarmento, Bruno; Castro, Flávia. Autor correspondente: Castro, Flávia. "Development of a breast cancer triple spheroid as a platform for drug screening". Trabalho apresentado em 3º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA (ENJIO), 2021.
  12. Garizo, Ana Rita; Castro, Flávia; Almeida, Andreia; Benardes, Nuno; Martins, Cláudia; Barrias, Cristina; Fialho, Arsénio M.; Sarmento, Bruno. Autor correspondente: Castro, Flávia. "P28-functionalized Gefitinib-loaded PLGA nanoparticles inhibit lung cancer progression in vivo". Trabalho apresentado em 31st Annual Conference of the European Society for Biomaterials (ESB 2021), 2021.
  13. Mariana Miranda Domingues; Castro, Flávia; Sarmento, Bruno. "Development of triple co-culture breast cancer spheroids for testing nanomedicines". Trabalho apresentado em 14th Encontro de Investigação Jovem da Universidade do Porto (IJUP), 2021.
  14. Andreia Almeida; Castro, Flávia; Simó Schwartz Jr; Marlene Lúcio; Bruno Sarmento. "Camptothecin-loaded chitosan micelles: a novel strategy for colorectal cancer therapy". Trabalho apresentado em 3rd SPLC-CRS: Young Scientists Virtual Meeting, 2021.
  15. Castro, Flávia. "Chitosan/y-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer". Trabalho apresentado em Conference Cancer Biology: From Basic to Translational Research (Webinar), 2020.
  16. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina L.; Serre, Karine; Gartner, Fátima; Barbosa, Mário A.; Gonçalves, Raquel M.; de Wever, Olivier; Oliveira, Maria J.. "Chitosan/poly(y-glutamic acid) nanoparticles and radiotherapy: a winning combination to fight cancer.". Trabalho apresentado em I ASEICA-ASPIC International Meeting – Current Trends in Immunotherapy Research and Treatment | Salamanca, Spain, 2019.
  17. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina P.; Gartner, Fátima; Serre, Karine; Barbosa, Mário A.; Gonçalves, Raquel M.; de Wever, Olivier; Oliveira, Maria J.. "Chitosan/poly(y-glutamic acid) nanoparticles and radiotherapy: a winning combination to fight cancer". Trabalho apresentado em Interrogations at the BioInterfaces: 7th Advanced Summer School | Porto, Portugal, 2019.
  18. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina P.; Gartner, Fátima; Serre, Karine; Barbosa, Mário A.; Gonçalves, Raquel M.; de Wever, Olivier; Oliveira, Maria J. "Re-educating the tumor immune landscape: chitosan and poly(y-glutamic acid) nanoparticles in sight". Trabalho apresentado em XLV Annual Meeting Sociedade Portuguesa de Imunologia (SPI) - Leaping forward translational immunology | Coimbra, Portugal, 2019.
  19. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina L.; Serre, Karine; Gartner, Fátima; Barbosa, Mário A.; de Wever, Olivier; Gonçalves, Raquel M.; Oliveira, Maria J.. "Reprogramming the breast tumor microenvironment: chitosan and poly(y-glutamic acid) nanoparticles in sight". Trabalho apresentado em 26th Porto Cancer Meeting: The Cancer Ecosystem: From Research to Pathology and Treatment | Porto, Portugal, 2019.
  20. Angela Margarida Costa; Martins, Flávia; Oliveira, Rosa; Cavadas, Bruno; Pinto, Filipe; Cardoso, AP; Castro, Flávia; et al. "Modulation of macrophage-cancer cell interaction by the hypoxic colon cancer microenvironment". Trabalho apresentado em I ASEICA-ASPIC International Meeting, 2019.
  21. Martins, Flávia; Oliveira, Rosa; Cavadas, Bruno; Pinto, Filipe; Cardoso, AP; Castro, Flávia; Angela Margarida Costa. "Hypoxia alters colon cancer macrophage-cancer cell interactions". Trabalho apresentado em SICR 2019 ¿ Symposium on Immunomodulation in Cancer & Regeneration, 2019.
  22. Oliveira, Rosa; Martins, Flávia; Cavadas, Bruno; Pinto, Filipe; Cardoso AP; Castro, Flávia; Angela Margarida Costa. "Colon cancer hypoxic ecosystem alters macrophage-cancer cell interactions.". Trabalho apresentado em XXVI Porto Cancer Meeting, 2019.
  23. Castro, Flávia; Almeida, Rui; Pereira, Catarina L.; Pinto, Marta L.; Barbosa, Mário A.; Oliveira, Maria J.; Gonçalves, Raquel M.. "Contribution of Chitosan (Ch) and poly(gamma)-glutamic (PGA) to the immunomodulatory role of Ch/PGA-based nanoparticles.". Trabalho apresentado em 29th Annual Congress of the European Society for Biomaterials | Maastricht, Netherlands, 2018.
  24. Castro, F; Pinto, ML; Silva, AM; Pereira, CL; Santos, SG; Barbosa, MA; Wever, OD; et al. "PO-420 harnessing chitosan/Poly(y)-glutamic acid nanoparticles for immunomodulation at the tumour microenvironment". Trabalho apresentado em EACR25 – 25h Biennial Congress of the European Association for Cancer Research: From Fundamental Insight to Rational Cancer Treatment | Amsterdam, Netherlands, 2018.
    10.1136/esmoopen-2018-eacr25.931
  25. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina L.; Barbosa, Mário A.; Gonçalves, Raquel M.; Oliveira, Maria J.. "Harnessing Chitosan/ poly(¿-glutamic acid) nanoparticles for anticancer therapy". Trabalho apresentado em XLIII Annual Meeting of the Portuguese Society for Immunology (SPI): Breaking the barriers of immunotherapy and vaccination: realities and challenges | Porto, Portugal, 2018.
  26. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina P.; Barbosa, Mário A.; de Wever, Olivier; Serre, Karine; Goncalves, Raquel M.; Oliveira, Maria J.. "Reprogramming antigen-presenting cells: a chitosan/pga nanoparticles for immunomodulatory therapy". Trabalho apresentado em Oncopoint 2018 | Ghent, Belgium, 2018.
  27. Martins, Flávia; Oliveira, Rosa; Pinto, Filipe; Castro, Flávia; Cardoso, AP; Cavadas, Bruno; Angela Margarida Costa. "The importance of considering hypoxia on the macrophage-cancer cell cross-talk". Trabalho apresentado em XXV Porto Cancer Meeting, 2018.
  28. Oliveira, Rosa; Martins, Flávia; Castro, Flávia; Cardoso, AP; Oliveira MJ; Angela Margarida Costa. "Unravel the role of hypoxia at the tumor microenvironment: a focus on macrophage-cancer cell interplay". Trabalho apresentado em 7th i3S Annual Meeting, 2018.
  29. Castro, Flávia; Cardoso, Ana P.; Pinto, Marta L.; Silva, Andreia M.; Pereira, Catarina P.; Barbosa, Mário A.; Gonçalves, Raquel M.; Oliveira, Maria J.. "Reprogramming antigen-presenting cells: a chitosan/y-PGA nanoparticles for anticancer therapy.". Trabalho apresentado em Defence is the Best Attack: Immuno-Oncology Breakthroughs | Barcelona, Spain, 2017.
  30. Castro, Flávia; Pinto, Marta L.; Pereira, Catarina P.; Barbosa, Mário A.; Goncalves, Raquel M.; Oliveira, Maria J.. "Reeducating antigen-presenting cells: an interferon-gamma delivery system for anticancer therapy". Trabalho apresentado em XI National Congress of the Italian Society of Immunology, clinical Immunology and allergology | Bari, Italy, 2017.
  31. Castro, Flávia; Cardoso, Ana P.; Teixeira, Graciosa Q.; Barbosa, Mário A.; Goncalves, Raquel M.; Oliveira, Maria J.. "An Interferon-y-delivery system based on chitosan/poly-y-glutamic acid nanoparticles as cancer immunotherapy". Trabalho apresentado em 2nd Aspic International Congress | Porto, Portugal, 2017.
  32. Wilton J; Pereira-Castro, I.; Freitas, Jaime; Angela Margarida Costa; Castro, Flávia; Oliveira, MJ; Moreira, Alexandra. "Mechanisms of gene regulation in the crosstalk of the cancer ¿ macrophage microenvironment". Trabalho apresentado em SICR2017 ¿ Symposium on Immunomodulation in Cancer & Regeneration,, 2017.
  33. Castro, Flávia; Cardoso, Ana P.; Pinto, Marta L.; Gonçalves, Raquel M.; Oliveira, Maria J.. "An interferon gamma-delivery system for cancer immunotherapy". Trabalho apresentado em Cell-VIB Symposium: Hallmarks of Cancer | Ghent, Belgium, 2016.
  34. Castro, Flávia; Cardoso, Ana P.; Teixeira, Graciosa Q.; Barbosa, Mário A.; Gonçalves, Raquel M.; Oliveira, Maria J. "An interferon-gamma-delivery system for cancer immunotherapy". Trabalho apresentado em 5th International Symposium in Applied Bioimaging: Disease in Focus | Porto, Portugal, 2016.
  35. Castro, Flávia; Cardoso, Ana P.; Teixeira, Graciosa Q.; Barbosa, Mário A.; Gonçalves, Raquel M.; Oliveira, Maria J.. "Targeting antigen-presenting cells: an interferon-gamma-delivery system for immunotherapy". Trabalho apresentado em XLII Annual Meeting of the Portuguese Society for Immunology (SPI)- Immunity, from cells to organisms | Oeiras, Portugal, 2016.
  36. Castro, Flávia; Cardoso, Ana P.; Pinto, Marta L.; Gonçalves, Raquel M.; Oliveira, Maria J.. "An Interferon-y-delivery system based on chitosan/poly-y-glutamic acid nanoparticles as cancer immunotherapy". Trabalho apresentado em XLI Annual Meeting of the Portuguese Society of Immunology (SPI) | Braga, Portugal, 2015.
  37. Castro, Flávia; Cardoso, Ana P.; Teixeira, Graciosa Q.; Barbosa, Mário A.; Gonçalves, Raquel M.; Oliveira, Maria J.. "A nanosized Interferon-y-delivery system modulates macrophages phenotype counteracting their stimulating role on cancer cell invasion". Trabalho apresentado em 1st Symposium on Immunomodulation in Cancer and Regeneration (SICR) | Porto, Portugal, 2015.
  38. Castro, Flávia; Cardoso, Ana P.; Teixeira, Graciosa Q.; Barbosa, Mário A.; Gonçalves, Raquel M.; Oliveira, Maria J.. "An Interferon-y-delivery system based on chitosan/poly-y-glutamic acid nanoparticles as cancer immunotherapy". Trabalho apresentado em Advanced Summer School: The nano/medicine interface | Porto, Portugal, 2015.
  39. Castro, Flávia; Cardoso, Vânia; Silvestre, Ricardo; Pedrosa, Jorge; Saraiva, Margarida; Castro, António G.; Torrado, Egídio. "IL-10 mediates susceptibility to Listeria monocytogenes infection by modulating the accumulation and differentiation of CD11b+ Ly6C+ monocytes". Trabalho apresentado em XL Annual Meeting of the Portuguese Society of Immunology (SPI) | Lisboa, Portugal, 2014.
  40. Castro, Flávia; Cardoso, Ana Filipa; Teixeira, Lúcia M.; Pedrosa, Jorge; Castro, António G.; Torrado, Egídio; Saraiva, Margarida; Pais, Teresa Faria. "Impact of myeloid restricted SIRT2 absence during Mycobacterium tuberculosis infection". Trabalho apresentado em ". XL Annual Meeting of the Portuguese Society of Immunology (SPI) | Lisboa, Portugal, 2014.
  41. Castro, Flávia; Teixeira, Lúcia M.; Pedrosa, Jorge; Saraiva, Margarida; Torrado, Egídio; Castro, António Gil. "IL-10 over-expression during T cell priming impacts the inflammatory response to Mycobacterium tuberculosis in the lung". Trabalho apresentado em XXXIX Annual Meeting of the Portuguese Society of Immunology (SPI) | Coimbra, Portugal, 2013.
Resumo em conferência
  1. Magalhães, Inês; Azevedo, M. J. ; Castro, Flávia; Maria José Oliveira; Angela M Costa; Sampaio-Maia, Benedita. ""Impact of maternal obesity on early-life microbiota-induced immune system priming"". Trabalho apresentado em IJUP 2023 - Encontro de Investigação Jovem da Universidade do Porto, Porto, 2023.
    Aceite para publicação
  2. Ana Rita Santos; Cardoso, AP; Pereira, Flávia; Castro, Flávia; Magalhães, Maria Inês; Maria José Oliveira; Angela M Costa. ""Unravel the role of hypoxia on immunomodulation at the colon cancer microenvironment"". Trabalho apresentado em IJUP 2022 - Encontro de Investigação Jovem da Universidade do Porto, Porto, 2022.
    Publicado
  3. Castro, Flávia; Marta Laranjeiro Pinto; Andreia Machado Silva; Catarina Leite Pereira; Olivier de Wever; Karine Serre; Raquel Madeira Gonçalves; Maria José Oliveira. "Reprogramming antigen-presenting cells: a chitosan/y-PGA nanoparticles for anticancer therapy". Trabalho apresentado em 8th International conference on Tumor Microenvironment: Progression, Therapy & Prevention, Lisbon, 2018.
    Publicado
  4. Costa, Ângela Margarida; Martins, Flávia; Oliveira, Rosa; Pinto, Filipe; Castro, Flávia; Cardoso, Ana Patrícia; Cavadas, Bruno; et al. "The hypoxia impact in the macrophage-driven cancer cell invasive phenotype". Trabalho apresentado em 8th International Conference on Tumor Microenvironment: Progression, Therapy & Prevention, Lisbon, 2018.
    Publicado
  5. Castro, F; Pinto, ML; Silva, AM; Pereira, CL; Santos, SG; Barbosa, MA; Wever, OD; et al. "PO-420 harnessing chitosan/Poly(y)-glutamic acid nanoparticles for immunomodulation at the tumour microenvironment". Trabalho apresentado em 25th Biennial Congress of the European Association for Cancer Research (EACR25), Amsterdam, 2018.
    Publicado • 10.1136/esmoopen-2018-eacr25.931
  6. Wilton J; Freitas Jaime; Pereira-Castro I; Angela Margarida Costa; Castro, Flávia; Oliveira MJ; Moreira, Alexandra. "Don¿t shoot the messenger: RNA at the center of unraveling mechanisms of gene regulation in the cancer-macrophage microenvironment". Trabalho apresentado em 8th International conference on Tumor Microenvironment, Lisboa, 2018.
    10.1007/s12307-018-0212-6
  7. Martins, Flávia; Castro, Flávia; Pinto, Marta Laranjeiro; Silva, Ana João; Sousa, Bárbara; Oliveira, Maria José; Costa, Ângela Margarida. "The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay". Trabalho apresentado em 12th YES Meeting, Porto, 2017.
    Publicado
Tese / Dissertação
  1. Castro, Flávia. "Targeting antigen-presenting cells: chitosan/poly(y-glutamic acid) nanoparticles as adjuvants to anticancer therapy". Doutoramento, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2019.
  2. Castro, Flávia. "Impact of IL-10 and SIRT2 in the protective immune response to Mycobacterium tuberculosis and Listeria monocytogenes infections". Mestrado, Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, 2014.

Propriedade Intelectual

Patente
  1. Ferreira, José Alexandre; da Silva, A.M.N.; Freitas, Rui; Santos, Lúcio; Relvas-Santos, Marta; Gaiteiro, Cristiana; Peixoto, Andreia; et al. 2021. "CD44 GLYCOEPITOPES AND CHIMERIC VACCINE GLYCOCONJUGATES FOR CANCER THERAPY AND SYNTHESIS METHODS THEREOF".
    Pendente
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/09/24 Chitosan and poly-y-glutamic acid nanoparticles: from lab to clinic 3rd Encontro Nacional de Jovens Investigadores em Oncologia (ENJIO)
Liga Portuguesa Contra o Cancro (Porto, Portugal)
2021/09/08 Chitosan/poly(y-glutamic acid) nanoparticles synergize with IFN-y to fight breast cancer 31st Annual Conference of the European Society for Biomaterials (ESB 2021)
European Society for Biomaterials (Porto, Portugal)
2021/06/04 Nanomedicine and Cancer: from lab to clinical practice BIOENG DAY
Universidade de Trás-os-Montes e Alto Douro (UTAD) (Vila Real, Portugal)
2021/05/05 Ch-based biomaterials for tumor microenvironment immunomodulation: a systematic review 14th Encontro de Investigação Jovem da Universidade do Porto (IJUP)
Universidade do Porto (Porto, Portugal)
2020/12/13 Chitosan/poly(y-glutamic acid) nanoparticles and radiotherapy: a winning combination to fight cancer 11TH World Biomaterials Congress
2020/09/24 Chitosan/y-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer Nanoscience and Nanotechnology International Conference (NanoPT 2020)
Phantoms Foundation (Porto, Portugal)
2020/09/18 Exosome membrane-coated biomimetic nanoparticles for higher cargo and better targeted delivery of anticancer agents Cancer Challenge Workshop
i3S - Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2019/12/12 Harnessing chitosan/poly(y-glutamic acid) nanoparticles to reprogram breast tumor microenvironment Biotech in vivo Symposium
Escola Superior de Saúde, Politécnico do Porto, Portugal (por, Portugal)
2019/11/28 Harnessing chitosan/poly(y-glutamic acid) nanoparticles to reprogram breast tumor microenvironment i3S Annual Meeting
i3S -Instituto de Investigação e Inovação em Saúde
2019/09/12 Chitosan/poly(y-glutamic acid) nanoparticles and radiotherapy: a winning combination to fight cancer I ASEICA-ASPIC International Meeting: Currents Trends in immunotherapy research and treatment
ASEICA-ASPIC (Salamanca, Espanha)
2019/09/09 Harnessing chitosan and poly(y-glutamic acid) nanoparticles to reprogram the breast tumor microenvironment 30th Annual Conference of the European Society for Biomaterials
ESB - European Society for Biomaterials (Dresden, Alemanha)
2019/06/23 Harnessing chitosan/poly(y-glutamic acid) nanoparticles to reprogram breast tumor microenvironment 3rd Symposium on Immunomodulation In Cancer & Regeneration: T-Cells And Immunotherapies
i3S (PORTO, Portugal)
2019/06/05 Harnessing chitosan/¿-PGA nanoparticles to reprogram the tumor immune landscape i3S Young Scientists Seminar
i3S - Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2019/02/04 Reprogramming the immune landscape at the tumor microenvironment: Chitosan/¿-PGA nanoparticles in sight BioengineeringHub Seminars
i3S (Porto, Portugal)
2018/09/11 Development of biomaterials-based immunotherapy: chitosan and poly(gamma)-glutamic acid nanoparticles as immunomodulatory players at the tumor microenvironment, 29th European Conference on Biomaterials
European Society for Biomaterials (Masttricht, Países Baixos)
2018/06/11 Reprogramming antigen-presenting cells: a chitosan/y-PGA nanoparticles for anticancer therapy, 8th conference of the International Cancer Microenvironment: Progression, Therapy and Prevention
International Cancer Microenvironment Society (Lisboa, Portugal)
2018/05/10 Reprogramming antigen-presenting cells: a chitosan/y-PGA nanoparticles for anticancer therapy 3th ASPIC International Congress
ASPIC
2018/02/02 Reprogramming antigen-presenting cells: a chitosan/y-PGA nanoparticles for immunomodulatory therapy Oncopoint
Cancer Research Institute of Ghent (CRIG) (Ghent, Bélgica)
2017/07/03 Reprogramming antigen-presenting cells: a chitosan/y-PGA nanoparticles for anticancer therapy 4th Annual BiotechHealth Symposium: “Spotting the differences: Biotechnology driving precision medicine
BiotechHealth PhD Program (Porto, Portugal)
2017/06/23 Harnessing Chitosan/ poly(y-glutamic acid) nanoparticles for anticancer therapy. 2nd Symposium on Immunomodulation in cancer and Regeneration
i3S
2017/02/09 Re-educating antigen-presenting cells: an interferon-gamma delivery system for cancer immunotherapy International Workshop: Translating Colorectal Cancer Research
EuCOLONGENE, COST (Porto, Portugal)
2014/11/13 IL-10 over-expression during T cell priming impacts the inflammatory response to Mycobacterium tuberculosis in the lung XXXIX Annual Meeting of the Portuguese Society of Immunology
Sociedade Portuguesa de Imunologia (Coimbra, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2024/02 - Atual Engineered Dendritic Cells-derived Extracellular Vesicles: Potential for Cancer Immunotherapy
Orientador de Margarida Oliveira Coelho
 Bioengenharia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/09 - Atual Dissecting the tumor radioresistence in Triple-negative breast cancer
Orientador de Ana Mafalda Macedo Nunes da Silva
 Molecular Biomedicine (Mestrado)
Universidade de Aveiro, Portugal
2022/11/01 - Atual Engineering Hybrid Exosomes For Breast Cancer Vaccine - HI-FORCE
Orientador de Sofia Torres Ferrando Alves Quintas
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/01/01 - Atual Development of a Novel Combination Therapy for Colorectal Cancer based on CD44v6-Targeted Chemotherapy with Immunotherapy
Coorientador de Ana Baião
Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (Doutoramento)
Universidade do Porto, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/01/01 - Atual Dissect the role of the tumor microenvironment to battle cancer radioresistance and immune escape
Coorientador
 Doctoral Programme on Cellular and Molecular Biotechnology Applied to Health Sciences (Doutoramento)
Universidade do Porto, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Gustave Roussy Département de Radiothérapie, França
2023/01/02 - 2023/10 Dissecting the effect of mechanical cues on fibroblast/macrophage crosstalk in the context of tissue fibrosis
Coorientador de Francisca Vieira
 Bioengenharia (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2022/03/01 - 2022/10/04 Mechanomodulatory Hydrogel to Probe the Effect of Mechanical Cues on Fibroblast Response
Coorientador
 Bioengineering (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2022/05/01 - 2022/08/31 Development of advanced breast cancer 3D models
Orientador
 Biomedical Engeneering (Licenciatura/Bacharelato)
Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2021/01/01 - 2021/10/31 Development of triple co-culture breast cancer spheroids for testing nanomedicines
Orientador
 Master in Bioengeneering (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal
2019/09/01 - 2020/07/31 Engineering Ch/y-PGA Nanoparticles to Reshape the Tumor Microenvironment
Coorientador
 Mestrado em Oncologia (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/10/01 - Atual I am Theme Coordinator of the 1st and 2nd edition of International Festival Pint of Science at Guimarães, Portugal which brings scientists to share their latest research to the community, mainly in the bars, pubs and cafes. (2020/05/11)
Festival (Membro da Comissão Organizadora)
 Pint of Science, Reino Unido

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2023/12/12 Functional Glycoproteomics Characterization of Gastric Cancer Cells Expressing Immature O-Glycans
Arguente principal
 Martina Dourado Gonçalves (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/12/11 Modelling osteosarcoma to address the potential of a nanotechnology-based immunomodulatory therapy
Arguente principal
 Sofia Daniela Ribeiro Magalhães Cardoso Costa (Mestrado)
Universidade do Porto Departamento de Química e Bioquímica, Portugal
2023/05 Towards the development of a 3D cell model to study interactions between glioma cells and microglia
Arguente principal
 Francisco de Castro Sobral (Mestrado)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal
2023/01/31 Rigor and standardization in extracellular vesicle research to enable clinical translation
Arguente
 Quentin Roux (Doutoramento)
Universitair Ziekenhuis Gent Kenniscentrum Gezondheidszorg Gent, Bélgica
2022/11/08 Decoding the role of inflammatory transcripts and microRNAs in macrophage polarization for bone repair
Arguente principal
 Maria Rodrigues Lopes (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/12/17 Development of cancer nanovaccines based on glyco-neoantigens
Arguente principal
 Beatriz Gusmão Frango Teixeira (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2020/10/14 Characterization of circulating tumor cells (CTCs) isolated on a microfluidic chip
Arguente principal
 Maria Gabriela Ferreira da Silva (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2021/08 - Atual 4th PhDay: Break borders and build opportunities i3S - Instituto de Investigação e Inovação em Saúde
2020/10/01 - Atual 3rd PhDay | Back to the Future i3S - Instituto de Investigação e Inovação em Saúde
2023/06/14 - 2023/10/04 6th i3S PhD Symposium - Brilliant PhDs, brighter future: Shaping Science together! i3S
2016/01/03 - 2016/06/21 3rd Annual BiotechHealth Symposium 2016: Emerging Technologies in Health Sciences i3S - Instituto de Investigação e Inovação em Saúde

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2022/09/01 - Atual Frontiers in Immunology (1664-3224) Frontiers
2022/09/01 - Atual Frontiers in Oncology Frontiers

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2023/04/11 - Atual Chair of Health Sciences VI session. Evaluator of oral communications. Evaluator of poster presentations in Health Sciences field.
Avaliador
 Universidade do Porto, Portugal
2021/08 - Atual Abstracts Evaluation of 4th PhDay: Break borders and build opportunities
Avaliador
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/02/01 - Atual Abstracts Evaluation in the field of Cancer Nanomedicine and Immunomodulation for 2021 Controlled Release Society (CRS) Virtual Annual Meeting, 25-29th July
Avaliador
 The Controlled Release Society (CRS), Estados Unidos
2020/01/02 - Atual Abstracts Evaluation in the field of Cancer Nanomedicine and Immunomodulation for Controlled Released Society Annual Meeting & Exposition, 27th June-1st July, Las Vegas, Nevada, USA.
Avaliador
 The Controlled Release Society (CRS), Estados Unidos
2023/04/01 - 2023/04/30 Abstracts Evaluation in the field of Cancer Nanomedicine and Immunomodulation for 2023 Controlled Release Society (CRS) Annual Meeting, 24-28th July, Las Vegas, EUA
Avaliador
 The Controlled Release Society (CRS), Estados Unidos
2023/04/01 - 2023/04/30 Abstracts Evaluation in the field of Cancer Nanomedicine, Immunomodulation and 3D cancer models for 33rd Annual Conference of the European Society for Biomaterials, 4-8th September, Davos, Switzerland.
Avaliador
 European Society for Biomaterials, França
2020 - 2020 Abstracts Evaluation of 3rd PhDay | Back to the Future
Avaliador
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/09/09 - 2019/09/13 Poster Evaluation at 30th Annual Conference of the European Society for Biomaterials, 9-13 September 2019, Dresden, Germany.
Avaliador
 European Society for Biomaterials, França

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021/09/24 - Atual "Nanomedicines for Cancer Therapy" at 5th Advanced Course on "Nanotechnology, Drug Delivery and Drug Targeting", under the Doctoral Program of Biological Sciences Applied to Health, at Instituto Universitário de Ciências da Saúde (CESPU). Doctoral Program of Biological Sciences Applied to Health (Doutoramento) Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2020/09/24 - Atual "Nanomedicine for Cancer Therapy" at 4th Advanced Course on "Nanotechnology, Drug Delivery and Drug Targeting", under the Doctoral Program of Biological Sciences Applied to Health, at Instituto Universitário de Ciências da Saúde (CESPU). Programa Doutoral de Ciências Biológicas Aplicadas à Saúde (Doutoramento) Instituto Universitário de Ciências da Saúde, Portugal
2019/09/26 - Atual "Immunotherapy in Cancer" - Optional Curricular Unit (UCO) Invasion & Metastasis , FMUP, Universidade do Porto. Mestrado Integrado em Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2020/11/12 - 2020/11/12 "Immunomodulatory Nanomedicines for Cancer Therapy" - Optional Curricular Unit (UCO) Invasion & Metastasis , FMUP, Universidade do Porto. Medicina Universidade do Porto Faculdade de Medicina, Portugal

Entrevista (jornal / revista)

Descrição da atividade Jornal / Forum
2020/10/14 Interview for LUSA - Portuguese News Agency regarding our work published in Biomaterials about of chitosan/pga nanoparticles- based immunotherapy to potentiate radiotherapy in breast cancer LUSA
2019/10/03 The interview was about the recognition of my work at the European Conference of Society for Biomaterials, in Desden, Germany. My PhD work was recognized with a Best Student Award by European Society for Biomaterials. Notícias Universidade do Porto

Entrevista / Programa (rádio / tv)

Programa Tema
2022/10/01 - Atual Magazine ACTIVA | Interview at the Breast Cancer Awareness Month to explain the last advances of our teamwork in the breast cancer therapies. Breast Cancer Awareness Month
2020/02/04 - Atual Jornal da Tarde | RTP. This tv show was about two new investigations at i3S to fight cancer, where one of them was my PhD work, specifically the therapeutic combination of radiotherapy with chitosan/pga nanoparticles in breast tumor models. World Cancer Cancer Day

Membro de associação

Nome da associação Tipo de participação
2024/02/05 - Atual European Society for Clinical Investigation (ESCI) Association Member
2017/09/01 - Atual European Association of Biomaterials (ESB) Member
2016/02/05 - Atual Portuguese Association for Cancer Research (ASPIC) Member
2016/01/01 - Atual Ambassador of European Society for Cancer Research (EACR) Member and Ambassador
2014/10/01 - Atual Portuguese Association of Immunology (SPI) Member

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2020/09/09 - Atual Evaluation and Discussion of the Project Dissertation "Decoding the Crosstalk Between Dendritic Cells and Bladder Cancer-Associated Glycans: A Way to Identify Novel Immunotherapy Targets" of student Andreia Rafaela Linhares Miranda, under supervision of Dr José Alexandre Ribeiro de Castro Ferreira. Universidade do Porto Faculdade de Medicina, Portugal

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2022/07/01 - Atual BMC Cancer Springer Nature
2022/06/01 - Atual iSCIENCE Cell Press
2022/04 - Atual Annals of Medicine Taylor & Francis Online
2022 - Atual International Journal of Molecular Sciences MDPI
2022 - Atual Scientific Letters (2795-5117) IUCS-CESPU
2021/07 - Atual Cancers MDPI
2021 - Atual Cells MDPI
2021 - Atual Biosensors MDPI
2020/05 - Atual Drug Delivery and Translational Research Springer
2020/05 - Atual European Journal of Pharmaceutical Sciences (0928-0987) Elsevier
2020/02/01 - Atual Biomaterials Science (2047-4849) The Royal Society of Chemistry
2020 - Atual ACS Nano American Chemical Societ

Tutoria

Tópico Nome do aluno
2024/01/08 - Atual Unveil the role of macrophages and T regulatory cells in lung cancer radioresistance Sergio Léon
2020/01/03 - Atual CD44v6-Targeted Nanoparticles for Colorectal Cancer Combination Therapy. Ana Baião
2020 - Atual Impact of tumor cells´glycosylation on DC maturation and activation. Rafaela Miranda
2019/06/01 - Atual Development of cancer vaccines based on glyco-neoantigens. Rui Filipe Neves Freitas
2023/10/01 - 2023/11 The role of macrophages on response of breast cancer to Bevacizumab Cátia Almeida
2021/09 - 2021/12 Impact of Iron Nanoparticles on macrophage polarization using a 3D breast cancer model. Camila Sales Nascimento
2020/01/01 - 2021/06/30 Chitosan micelles for drug delivery in colorectal cancer. Andreia Marina Silva
2020/06/01 - 2020/12/31 Aberrant Glycosylation and Immune Evasion. Elisabete Fernandes
2020/01/01 - 2020/12/31 Targeting tumor microenvironment to improve the chemotherapeutic treatment in metastatic colorectal cancer. Maria José Silveira
2019/09/09 - 2020/09/30 Role of CCL18 on colorectal cancer immunomodulation. Ana Manuela Canha Borges
2019/01/02 - 2019/11/30 The Interplay Between Adipose Tissue and Renal Cell Carcinoma: Decoding the Obesity Paradox. Miguel Mendes Ferreira
2018/10/01 - 2019/10/31 Tumour Microenvironment and Aberrant Glycosylation in bladder cancer. Andreia Filipa Ferreira Peixoto
2018/09/01 - 2019/10/31 Effect of normal and tumor extracellular matrix in cancer stem cell-like properties. Sara Monteiro Ferreira
2018/10/01 - 2019/10/09 The macrophage-iNKT axis: macrophage survival and activation are modulated upon invariant NKT interaction. José Pedro Loureiro
2017/09/09 - 2018/11/28 Adrenergic control of human macrophages polarization and its putative impact in cancer progression. Diogo da Silva Adão
2017/09/16 - 2018/07/31 The role of the hypoxic tumor microenvironment on the macrophage-tumor cell interplay. Flávia Martins
2017/03/01 - 2017/12/01 Mechanisms of gene regulation in the crosstalk of the cancer – macrophage microenvironment
2015/09/11 - 2016/11/30 In vitro characterisation of macrophage- colorectal/gastric cancer cell crosstalk. Ana João Mascarenhas da Silva
2015/01/03 - 2015/11/30 Elucidating the role of macrophages and CD4 +CD25 + regulatory T cells on colorectal cancer cell invasion. Maria Helena Cristiano Brigas
Distinções

Prémio

2022 EACR Travel Grant for participation in EACR 2022 Congress - Innovative Cancer Science: Translating Biology to Medicine, 20-23 June, 2022, Spain.
European Association For Cancer Research, Reino Unido
2022 ITC Conference Grant from CA17140 Cancer Nanomedicine COST Action for participation in ¿VIB Conferences: Recent insights into Immuno-Oncology, 17-18 June, 2022, Belgium.
European Cooperation in Science and Technology, Bélgica
2022 Best Speed-Talk and Poster at 4th Symposium on Immunomodulation in Cancer & Regeneration, 23 June, 2022, Porto, Portugal.
4th Symposium on Immunomodulation in Cancer & Regeneration, Portugal
2022 1st Raquel Seruca Award at 5th International ASPIC Conference
ASPIC - Associação Portuguesa de Investigação em Cancro, Portugal
2021 Best Oral Communication Award with " Chitosan/y-PGA nanoparticles: from the lab to the clinic?" at 3rd ENJIO Meeting
Liga Portuguesa Contra o Cancro, Portugal
2020 Julia Polak European Doctoral Award for my PhD Thesis "Targeting antigen-presenting cells: chitosan/poly(y-glutamic acid) nanoparticles as adjuvants to anticancer therapy"
European Society for Biomaterials, França
2020 Best Post Award by Liga Portuguesa Contra o Cancro with "Chitosan/PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer" at Conference Cancer Biology: From Basic To Translational Research, 25 Sept 2020, Portugal
Liga Portuguesa Contra o Cancro, Portugal
2019 Best Student Award with the oral communication at the 30th Annual Conference of the European Society for Biomaterials with "Harnessing chitosan and poly(y-glutamic acid) nanoparticles to reprogram the breast tumor microenvironment"
European Society for Biomaterials, França
2018 EACR Travel Grant for "25th Biennial Congress EACR: From Fundamental Insight to Rational Cancer Treatment", 30-3July, 2018, Amsterdam, Netherlands.
European Association For Cancer Research, Reino Unido
2018 SPI Travel Grant to develop the project "Development of an immunomodulatory delivery system to prevent cancer cell invasion and metastasis" at Laboratory of Experimental Cancer Research, Ghent University, Belgium.
Sociedade Portuguesa De Imunologia (SPI), Portugal
2018 Oncopoint Best Posters for "Reprogramming antigen-presenting cells: a chitosan/PGA nanoparticles for immunomodulatory therapy", 2018, Ghent, Belgium.
Cancer Research Institute Ghent , Bélgica
2017 EACR Travel Grant for Congress "Defence is the best attack: Immuno-Oncology Breakthroughs", 9-11 October, 2017, Barcelona.
European Association For Cancer Research, Reino Unido
2017 Short-term Scientific Missions, COST Action 2017, with project "The effect of immunomodulatory nanoparticles on macrophage cytoskeleton dynamics and their impact on cancer cell invasion".
European Cooperation in Science and Technology, Bélgica
2016 GESINAS - ImmunoTools Award 2016 with project: "Targeting colorectal cancer: a macrophage immunomodulatory-delivery system".
ImmunoTools, Alemanha

Outra distinção

2020 Honorable mention by 2020 Bioengineering Travel Award
Bioengeneering - Open Access Journal, Suiça
2020 Personality of the University of Porto
Universidade do Porto, Portugal