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Identificação

Identificação pessoal

Nome completo
Maria João Carlos da Silva Gama

Identificadores de autor

Ciência ID
7512-DFAB-5A75
ORCID iD
0000-0002-4943-0349

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
Formação
Grau Classificação
2001
Concluído
 Farmácia (Doutoramento)
Especialização em Especialidade: Biologia e Genética Molecular
Universidade de Lisboa, Portugal
"Ácido Retinóico e Expressão de Citocromos P450 Hepáticos: Estudos Sobre Regulação Dimórfica Sexual do Cyp3a2" (TESE/DISSERTAÇÃO)
 Aprovado com distinção e louvor por unanimidade
1988
Concluído
 Provas de Aptidão Pedagógica e Capacidade Científica (Outros)
Especialização em Bioquímica
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Muito Bom
1981
Concluído
 Licenciatura em Farmácia (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"n/a" (TESE/DISSERTAÇÃO)
 15/20
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/04/05 - Atual Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
2001/04/06 - 2006/04/04 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
1988/10/01 - 2001/04/05 Assistente (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
1983/11/07 - 1988/10/01 Assistente Estagiário (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
1981/10/01 - 1983/06/01 Estagiária Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
Projetos

Bolsa

Designação Financiadores
2022/01 - 2023/06 Modulação da disfunção mitocondrial por sinalização redox via modificações pós-tradução
Provided by PTCRIS: EXPL/BIA-BQM/0793/2021
 Fundação para a Ciência e a Tecnologia
2018/10 - 2022/09 Investigando o elo biofísico entre a doença de Gaucher e de Parkinson
Provided by PTCRIS: PTDC/BIA-BFS/29448/2017
 Fundação para a Ciência e a Tecnologia
2018/08 - 2022/07 TITANIC - CYP46A1 as a new TherapeutIcTAarget in NIemann-Pick type C disease
Provided by PTCRIS: PTDC/MED-NEU/29455/2017
 Fundação para a Ciência e a Tecnologia
2018/08 - 2022/07 Isoformas do PGC-1alpha como novos alvo terapêutico na Doença de Parkinson
Provided by PTCRIS: PTDC/MED-FSL/30104/2017
 Fundação para a Ciência e a Tecnologia
2013/06 - 2015/11 S-Glutathionylation in Parkinson´s Disease.
Provided by PTCRIS: 124942
 Fundação para a Ciência e a Tecnologia
2013/06 - 2015/11 Unraveling the neuroprotective role of TUDCA in Parkinson´s disease: targeting oxidative stress and mitophagy
Provided by PTCRIS: 124452
 Fundação para a Ciência e a Tecnologia
2011/01 - 2014/06 Control of neuronal signaling pathways by CYP46A1, an enzyme involved in brain cholesterol turnover
Provided by PTCRIS: 110809
 Fundação para a Ciência e a Tecnologia
2007/08 - 2010/12 Estrogen signaling and epigenetic modifications in the regulation of the CYP46A1 expression in the brain
Provided by PTCRIS: 64176
 Fundação para a Ciência e a Tecnologia
2007/01 - 2009/10 Molecular mechanisms involved in the transcriptional regulation of the human CYP46 gene - Implications in brain cholesterol homeostasis.
Provided by PTCRIS: 82707
 Fundação para a Ciência e a Tecnologia
2007/01 - 2009/10 Evaluation of the protective role of Glutathione S-Transferase pi against MPTP neurotoxicity
Provided by PTCRIS: 82406
 Fundação para a Ciência e a Tecnologia
2007/01 - 2009/07 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators
Provided by PTCRIS: 82303
 Fundação para a Ciência e a Tecnologia
2005/09 - 2008/06 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators
Provided by PTCRIS: 55955
 Fundação para a Ciência e a Tecnologia
2005/07 - 2008/04 Evaluation of the protective role of Glutathione S-Transferase pi against MPTP neurotoxicity
Provided by PTCRIS: 58171
 Fundação para a Ciência e a Tecnologia
2005/09 - 2008/02 Molecular mechanisms involved in the transcriptional regulation of the human CYP46 gene - Implications in brain cholesterol homeostasis.
Provided by PTCRIS: 55919
 Fundação para a Ciência e a Tecnologia
Produções

Publicações

Artigo em revista
  1. Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Costa, Daniela; Moutinho, Miguel; Mateus, Joana; Mendes de Almeida, Rita; et al. "Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 3 (2024): 166993. http://dx.doi.org/10.1016/j.bbadis.2023.166993.
    10.1016/j.bbadis.2023.166993
  2. Nunes, M.J.; Carvalho, A.N.; Sá-Lemos, C.; Colaço, M.; Cervenka, I.; Ciraci, V.; Santos, S.G.; et al. "Sustained PGC-1a2 or PGC-1a3 expression induces astrocyte dysfunction and degeneration". European Journal of Cell Biology 103 1 (2024): 151377. http://dx.doi.org/10.1016/j.ejcb.2023.151377.
    10.1016/j.ejcb.2023.151377
  3. Caria, Inês; Nunes, Maria João; Ciraci, Viviana; Carvalho, Andreia Neves; Ranito, Catarina; Santos, Susana G.; Gama, Maria João; et al. "NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 2 (2024): 166980. http://dx.doi.org/10.1016/j.bbadis.2023.166980.
    10.1016/j.bbadis.2023.166980
  4. Nunes, Maria João; Carvalho, Andreia Neves; Rosa, Alexandra I.; Videira, Paula A.; Gama, Maria João; Rodrigues, Elsa; Castro-Caldas, Margarida. "Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease". Journal of Molecular Medicine 102 3 (2024): 365-377. http://dx.doi.org/10.1007/s00109-023-02415-3.
    10.1007/s00109-023-02415-3
  5. Romina A. Guedes; Jorge H. Grilo; Andreia N. Carvalho; Pedro M. P. Fernandes; Ana S. Ressurreição; Vanessa Brito; Adriana O. Santos; et al. "New Scaffolds of Proteasome Inhibitors: Boosting Anticancer Potential by Exploiting the Synergy of In Silico and In Vitro Methodologies". Pharmaceuticals (2023): https://doi.org/10.3390/ph16081096.
    10.3390/ph16081096
  6. Kovalchuk, Daria Alexandrovna; Anjo, Sandra I.; Nunes, Maria João; Branco, Vasco; Santos, Fabiana; Caria, Inês; Castro-Caldas, Margarida; et al. "Cysteine redox post-translational modifications: the missing link between redox-signalling and mitochondrial dynamics and function in Parkinson’s disease?". Free Radical Biology and Medicine 201 (2023): 35. http://dx.doi.org/10.1016/j.freeradbiomed.2023.03.142.
    10.1016/j.freeradbiomed.2023.03.142
  7. Leonardo-Sousa, Carlota; Carvalho, Andreia Neves; Guedes, Romina A.; Fernandes, Pedro M. P.; Aniceto, Natália; Salvador, Jorge A. R.; Gama, Maria João; Guedes, Rita C.. "Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance". Molecules 27 7 (2022): 2201. http://dx.doi.org/10.3390/molecules27072201.
    10.3390/molecules27072201
  8. "Corrigendum to “Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy” [Mol. Cell. Neurosci., Volume 96, April 2019, Pages 1–9.]". Molecular and Cellular Neuroscience (2021): 103626-103626. http://dx.doi.org/10.1016/j.mcn.2021.103626.
    10.1016/j.mcn.2021.103626
  9. "Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson’s disease". Cell Death & Disease 10 11 (2019): http://dx.doi.org/10.1038/s41419-019-2078-z.
    10.1038/s41419-019-2078-z
  10. Rosa, A.I.; Duarte-Silva, S.; Silva-Fernandes, A.; Nunes, M.J.; Carvalho, A.N.; Rodrigues, E.; Gama, M.J.; et al. "Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease". Molecular Neurobiology (2018): 1-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045271175&partnerID=MN8TOARS.
    10.1007/s12035-018-1062-4
  11. Moreira, S.; Fonseca, I.; Nunes, M.J.; Rosa, A.; Lemos, L.; Rodrigues, E.; Carvalho, A.N.; et al. "Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease". Experimental Neurology 295 (2017): 77-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020310862&partnerID=MN8TOARS.
    10.1016/j.expneurol.2017.05.009
  12. Rosa, A.I.; Fonseca, I.; Nunes, M.J.; Moreira, S.; Rodrigues, E.; Carvalho, A.N.; Rodrigues, C.M.P.; Gama, M.J.; Castro-Caldas, M.. "Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1863 9 (2017): 2171-2181. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021192126&partnerID=MN8TOARS.
    10.1016/j.bbadis.2017.06.004
  13. Fonseca, I.; Gordino, G.; Moreira, S.; Nunes, M.J.; Azevedo, C.; Gama, M.J.; Rodrigues, E.; Rodrigues, C.M.P.; Castro-Caldas, M.. "Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells". Molecular Neurobiology 54 8 (2017): 6107-6119. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989831585&partnerID=MN8TOARS.
    10.1007/s12035-016-0145-3
  14. Fonseca, I.; Gordino, G.; Moreira, S.; Nunes, M.J.; Azevedo, C.; Gama, M.J.; Rodrigues, E.; Rodrigues, C.M.P.; Castro-Caldas, M.. "Erratum to: Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells (Molecular Neurobiology, (2017), 54, 8, (6107-6119), 10.1007/s12035-016-0145-3)". Molecular Neurobiology 54 8 (2017): 6120-6120. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992146179&partnerID=MN8TOARS.
    10.1007/s12035-016-0228-1
  15. Moutinho, M.; Nunes, M.J.; Correia, J.C.; Gama, M.J.; Castro-Caldas, M.; Cedazo-Minguez, A.; Rodrigues, C.M.P.; et al. "Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84981276916&partnerID=MN8TOARS.
    10.1038/srep30928
  16. Carvalho, A.N.; Marques, C.; Guedes, R.C.; Castro-Caldas, M.; Rodrigues, E.; Van Horssen, J.; Gama, M.J.. "S-Glutathionylation of Keap1: A new role for glutathione S-transferase pi in neuronal protection". FEBS Letters 590 10 (2016): 1455-1466. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965157697&partnerID=MN8TOARS.
    10.1002/1873-3468.12177
  17. Carvalho, A.N.; Firuzi, O.; Gama, M.J.; van Horssen, J.; Saso, L.. "Oxidative stress and antioxidants in neurological diseases: Is there still hope?". Current Drug Targets 17 16 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85002289743&partnerID=MN8TOARS.
    10.2174/1389450117666160401120514
  18. Moutinho, M.; Nunes, M.J.; Gomes, A.Q.; Gama, M.J.; Cedazo-Minguez, A.; Rodrigues, C.M.P.; Björkhem, I.; Rodrigues, E.. "Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells". Molecular Neurobiology 51 3 (2015): 1489-1503. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939872953&partnerID=MN8TOARS.
    10.1007/s12035-014-8828-0
  19. Nunes, M.J.; Moutinho, M.; Gama, M.J.; Rodrigues, C.M.P.; Rodrigues, E.. "Histone Deacetylase Inhibition Decreases Cholesterol Levels in Neuronal Cells by Modulating Key Genes in Cholesterol Synthesis, Uptake and Efflux". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872249052&partnerID=MN8TOARS.
    10.1371/journal.pone.0053394
  20. Carvalho, A.N.; Marques, C.; Rodrigues, E.; Henderson, C.J.; Wolf, C.R.; Pereira, P.; Gama, M.J.. "Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice.". Molecular neurobiology 47 2 (2013): 662-672. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886087240&partnerID=MN8TOARS.
  21. Milagre, I.; Olin, M.; Nunes, M.J.; Moutinho, M.; Lövgren-Sandblom, A.; Gama, M.J.; Björkhem, I.; Rodrigues, E.. "Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells". Neurochemistry International 60 2 (2012): 192-198. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855464848&partnerID=MN8TOARS.
    10.1016/j.neuint.2011.12.003
  22. Castro-Caldas, M.; Carvalho, A.N.; Rodrigues, E.; Henderson, C.; Wolf, C.R.; Gama, M.J.. "Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway". Molecular Neurobiology 45 3 (2012): 466-477. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867475229&partnerID=MN8TOARS.
    10.1007/s12035-012-8266-9
  23. Nunes, M.J.; Moutinho, M.; Milagre, I.; Gama, M.J.; Rodrigues, E.. "Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway". Journal of Lipid Research 53 9 (2012): 1910-1919. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864848297&partnerID=MN8TOARS.
    10.1194/jlr.M027680
  24. Castro-Caldas, M.; Carvalho, A.N.; Rodrigues, E.; Henderson, C.J.; Wolf, C.R.; Rodrigues, C.M.P.; Gama, M.J.. "Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease". Molecular Neurobiology 46 2 (2012): 475-486. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868089556&partnerID=MN8TOARS.
    10.1007/s12035-012-8295-4
  25. Carvalho, A.N.; Marques, C.; Rodrigues, E.; Henderson, C.J.; Wolf, C.R.; Pereira, P.; Gama, M.J.. "Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice". Molecular Neurobiology (2012): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868249992&partnerID=MN8TOARS.
    10.1007/s12035-012-8368-4
  26. Milagre, I.; Nunes, M.J.; Castro-Caldas, M.; Moutinho, M.; Gama, M.J.; Rodrigues, E.. "Neuronal differentiation alters the ratio of Sp transcription factors recruited to the CYP46A1 promoter". Journal of Neurochemistry 120 2 (2012): 220-229. http://www.scopus.com/inward/record.url?eid=2-s2.0-84155160627&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2011.07577.x
  27. Nunes, M.J.; Milagre, I.; Schnekenburger, M.; Gama, M.J.; Diederich, M.; Rodrigues, E.. "Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription". Journal of Neurochemistry 113 2 (2010): 418-431. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949724640&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2010.06612.x
  28. Milagre, I.; Nunes, M.J.; Moutinho, M.; Rivera, I.; Fuso, A.; Scarpa, S.; Gama, M.J.; Rodrigues, E.. "Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination". Journal of Alzheimer's Disease 22 4 (2010): 1209-1221. http://www.scopus.com/inward/record.url?eid=2-s2.0-79751484908&partnerID=MN8TOARS.
    10.3233/JAD-2010-100651
  29. Carvalho, Neves A.; Marques, C.; Rodrigues, E.; Pereira, P.; Gama, M. J.; Fisher, A; Hanin, I. "Effect of Proteasome Inhibition on MPP(+)-induced GSTP1 Expression in SH-SY5Y Cells". New Trends in Alzheimer and Parkinson Related Disorders: Adpd 2009 (2009): 279-287. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000281728600051&KeyUID=WOS:000281728600051.
  30. Castro-Caldas, M.; Milagre, I.; Rodrigues, E.; Gama, M.J.. "Glutathione S-transferase pi regulates UV-induced JNK signaling in SH-SY5Y neuroblastoma cells". Neuroscience Letters 451 3 (2009): 241-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-59149094693&partnerID=MN8TOARS.
    10.1016/j.neulet.2009.01.017
  31. Castro-Caldas, M.; Neves Carvalho, A.; Peixeiro, I.; Rodrigues, E.; Lechner, M.C.; Gama, M.J.. "GSTpi expression in MPTP-induced dopaminergic neurodegeneration of C57BL/6 mouse midbrain and striatum". Journal of Molecular Neuroscience 38 2 (2009): 114-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-69249220443&partnerID=MN8TOARS.
    10.1007/s12031-008-9141-z
  32. Milagre, Ines; Nunes, Maria Joao; Gama, Maria Joao; Rodrigues, Elsa. "DNA Demethylation and Histone Deacetylation Inhibition in the Derepression of CYP46A1 Expression". Drug Metabolism Reviews 41 (2009): 22-23. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000280164800042&KeyUID=WOS:000280164800042.
  33. Milagre, I.; Nunes, M.J.; Gama, M.J.; Silva, R.F.; Pascussi, J.M.; Lechner, M.C.; Rodrigues, E.. "Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors". Journal of Neurochemistry 106 2 (2008): 835-849. http://www.scopus.com/inward/record.url?eid=2-s2.0-51649087490&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2008.05442.x
  34. Milagre, I.; Nunes, M.J.; Gama, M.J.; Silva, R.F.; Pascussi, J.M.; Lechner, M.C.; Rodrigues, E.. "Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors (Journal of Neurochemistry (2008) 106, (835-849))". Journal of Neurochemistry 107 4 (2008): 1168-1168. http://www.scopus.com/inward/record.url?eid=2-s2.0-54349103837&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2008.05654.x
  35. Vilar, R.; Coelho, H.; Rodrigues, E.; Gama, M.J.; Rivera, I.; Taioli, E.; Lechner, M.C.. "Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease". European Journal of Neurology 14 2 (2007): 156-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846433663&partnerID=MN8TOARS.
    10.1111/j.1468-1331.2006.01590.x
  36. Fernandes, A.; Falcão, A.S.; Silva, R.F.M.; Gordo, A.C.; Gama, M.J.; Brito, M.A.; Brites, D.. "Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin". Journal of Neurochemistry 96 6 (2006): 1667-1679. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644812051&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.03680.x
  37. LECHNER, MC; TELHADA, MM; RIBEIRO, V; PEREIRA, TM; GAMA, MJ. "STRUCTURAL AND FUNCTIONAL-CHARACTERISTICS OF CYP3A GENES RELATED TO THE DEVELOPMENT-DEPENDENT PHENOTYPIC-EXPRESSION AND INDUCTION BY DEXAMETHASONE". Cytochrome P450 (1994): 125-128. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1994BA85R00018&KeyUID=WOS:A1994BA85R00018.
  38. HENRIQUE, D; GAMA, MJ; LECHNER, MC; ARCHAKOV, AI; BACHMANOVA, GI. "STRUCTURE AND FUNCTION OF CYP2C7 GENE PROMOTER". Cytochrome P-450 : Biochemistry and Biophysics (1992): 394-396. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1992BW93P00094&KeyUID=WOS:A1992BW93P00094.