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Carina Maranga completed the Master in Celular and Molecular Biology with Specialization in Neurobiology in 2016 by Universidade de Coimbra, Faculdade de Ciências e Tecnologia, and obtained the Biomedical Science Bachelor in 2014 from Universidade do Algarve. She attends the PhD in Bioengineering: Cell therapies and Regenerative Medicine by Universidade de Lisboa, Instituto Superior Técnico, since 2018. Carina published 3 articles in journals and 1 book chapter. Her work as author and co-author was presented in over 10 oral presentations and 18 poster presentations in national and international conferences. Carina participated in 8 events as workshops and meetings with Angelman Syndrome patients and also has received 4 awards. As Master student, she worked in an awarded projecto, then she received a Master fellowship and participated in a project from an industry (TEVA pharmaceutics) and now, as PhD Student, is working in a project that won two grants from a national and international foundations. Carina works in the areas of Medical and Health Sciences with emphasis on neurosciences, technologies involving the manipulation of hiPSCs and health-Related Biotechnology. In her curriculum the most frequent terms in the context of scientific and technological output are: hiPSCs; Cerebellar Organoids; Angelman Syndrome; Neuronal differentiation; Mitochondrial function; Huntington's Disease; HD models.
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Identificação

Identificação pessoal

Nome completo
Carina Maranga

Nomes de citação

  • Maranga, Carina

Identificadores de autor

Ciência ID
7811-C66B-F64C
ORCID iD
0000-0002-0003-4011

Endereços de correio eletrónico

  • carinamaranga@tecnico.ulisboa.pt (Profissional)
  • carinamaranga@medicina.ulisboa.pt (Profissional)

Telefones

Telefone
  • (+351) 21 423 320 (Profissional)

Moradas

  • Avenida Prof. Dr Cavaco Silva Instituto Superior Técnico , 2744-016, Porto Salvo, Oeiras, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biotecnologia Aplicada à Saúde
  • Ciências Médicas e da Saúde - Ciências da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2018/02/01 - 2022/06/01
Em curso
 Bioengineering: Cell Therapies and Regenerative Medicine (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Cerebellar organoids from hiPSCs to model Angelman Syndrome " (TESE/DISSERTAÇÃO)
2014 - 2016/09/13
Concluído
 Celular and Molecular Biology - Specialization in Neurobiology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Early mitochondrial modifications in YAC128 transgenic model of Huntington’s disease " (TESE/DISSERTAÇÃO)
 17
2014
Concluído
 Biomedical Sciences (Licenciatura)
Universidade do Algarve, Portugal
"Evaluation of oxidative stress in retinal cells from experimental models of diabetes" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/02/01 - 2018/02/01 Investigador (Investigação) CNC.IBILI, Portugal
CNC.IBILI, Portugal
Projetos

Bolsa

Designação Financiadores
2020 - Atual Exploring new therapeutic strategies for Angelman syndrome: A disease modelling approach based on 3D cerebellar organoids derived from patient iPSCs
PMJMCD 2019
Bolseiro de Doutoramento
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação Amélia de Mello
Em curso

Projeto

Designação Financiadores
2015/09 - 2016/09 Evaluation of oxidative stress and mitochondrial dysfunction in animal models and patients of Huntington's disease using Cu(II)-ATSM PET
NA
Master Student
Universidade de Coimbra, Portugal

CNC.IBILI, Portugal
Santa Casa da Misericórdia de Lisboa
Concluído

Outro

Designação Financiadores
2017/03 - 2018/02 Exploring the role of pridopidine on mitochondrial function and dynamics in Huntingtons disease models
NA
Bolseiro de Mestrado
Teva Pharmaceutical Industries Ltd
Concluído
Produções

Publicações

Artigo em boletim informativo
  1. Maranga, Carina; Vieira, Adriana A.; Bekman, Evguenia; da Rocha, Simão T.. "Ensaios clínicos em Angelman... e em Portugal?", Newsletter trimestral da Angel, 2020, https://mcusercontent.com/c1201a436f7baec28794d7be1/files/85b64f55-3c95-4997-a30f-ceca8eeac0b0/Newsletter_14.pdf.
Artigo em conferência
  1. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; da Rocha, Simão T.; Fernandes, Tiago G.; Bekman, Evguenia P.; Cabral, Joaquim. "Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience (SPN2019), Lisboa, 2019.
    Publicado
  2. Geva, Michal; Naia, Luana; Ly, Phillip; Lopes, Carla; Mota, Sandra; Maranga, Carina; Hayden, Michael R; Rego, Ana Cristina. "Pridopidine Rescues Multiple Mitochondrial Functions Impaired in Human and Mouse HD Models by Activation of the Sigma-1 Receptor". Trabalho apresentado em HSG 2019 – Huntington Study Group Annual Meeting, 2019.
    Publicado
Artigo em revista
  1. Maranga, Carina; Pereira, Carolina; Raposo, Ana Cláudia; Vieira, Adriana; Duarte, Sofia; Bekman, Evguenia P.; Milagre, Inês; da Rocha, Simão Teixeira. "Generation and characterization of induced pluripotent stem cell line (IBBISTi004-A) from an Angelman syndrome patient carrying a class II deletion of the maternal chromosome 15q11.2-q13". Stem Cell Research 61 (2022): 102757. http://dx.doi.org/10.1016/j.scr.2022.102757.
    10.1016/j.scr.2022.102757
  2. Naia, Luana; Ly, Phillip; Mota, Sandra I; Lopes, Carla; Maranga, Carina; Coelho, Patrícia; Gershoni-Emek, Noga; et al. "The Sigma-1 receptor mediates pridopidine rescue of mitochondrial function in Huntington Disease models". Neurotherapeutics (2021):
    Publicado
  3. Maranga, Carina; Fernandes, Tiago G.; Bekman, Evguenia; Teixeira da Rocha, Simão. "Angelman Syndrome: a journey through the brain". The FEBS Journal (2020): http://dx.doi.org/10.1111/febs.15258.
    10.1111/febs.15258
Capítulo de livro
  1. Maranga, Carina; Vieira, Adriana; Bekman, Evguenia; Rocha, Teixeira Simão. "iPSCs for modeling Angelman syndrome". In Induced Pluripotent Stem Cells – Novel Concepts. Portugal: Elsevier, 2020.
    Submetido • 10.2174/9781681081168115010008
Poster em conferência
  1. Maranga, Carina; Raposo, Ana Cláudia; Vieria, Adriana A.; Arez, Maria; Alípio Gomes; Laura Dias; Casanova, Miguel; Bekman, Evguenia P.; da Rocha, Simão Teixeira. "A PERSONALIZED STEM CELL TOOLKIT FOR MODELING HUMAN DISORDERS". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022.
  2. Alípio Gomes; Vieira, Adriana; Maranga, Carina; Casanova, Miguel; Laura Steenpass; Cabral, Joaquim; Fernandes, Tiago G.; da Rocha, Simão Teixeira; Bekman, Evguenia P.. "Correction of disease-causing mutation in Angelman syndrome patient derived iPSC line by CRISPR/Cas9". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022.
  3. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim; da Rocha, Simão Teixeira; Fernandes, Tiago G.; Bekman, Evguenia P.. "Recapitulating disease features in cerebellar organoids model of Angelman syndrome". Trabalho apresentado em 12th International Meeting of the Portuguese Society for Stem Cells and Cell therapies, 2022.
  4. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim M.S (AB13-9ED3-C821); da Rocha, Simão T.; Fernandes, Tiago; Bekman, Evguenia P.. "Modeling Angelman Syndrome with human induced pluripotent stem cell-derived cerebellar organoids". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021.
  5. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; Cabral, Joaquim M.S (AB13-9ED3-C821); da Rocha, Simão T.; Fernandes, Tiago G.; Bekman, Evguenia. "Modeling Angelman Syndrome with human induced pluripotent stem cell-derived cerebellar organoids". Trabalho apresentado em Vienna Biocenter PhD Symposium 2021 'Building Bridges', 2021.
  6. Maranga, Carina; Vieria, Adriana A.; Silva, Teresa P.; Fernandes, Tiago G.; Cabral, Joaquim M.S (AB13-9ED3-C821); da Rocha, Simão T.; Bekman, Evguenia P.. "Brain-in-a-dish approach for studying Angelman Syndrome". Trabalho apresentado em Neuroepigenetics: From Cells to Behaviour and Disease, 2020.
  7. Maranga, Carina; Silva, T.P.; Vaz, Sandra H.; Fernandes, Tiago G.; da Rocha, Simão T.; Bekman, Evguenia; Cabral, Joaquim M.S. "hiPSC-derived cerebellar organoids to model Angelman Syndrome". Trabalho apresentado em Organoids: Modelling Organ Development and Disease in 3D Culture - Virtual, 2020.
  8. Vieira, Adriana A.; Maranga, Carina; Gomes, Ana; Bekman, Evguenia; da Rocha, Simão T.. "Modeling of Angelman Syndrome using the Neural Commitment of Patient-Specific iPSCs". Trabalho apresentado em Innovate Competition – AstraZeneca Foundation, 2020.
  9. Geva, Michal; Schenkman, Marina; Naia, Luana; Ly, Phillip; Mota, Sandra; Lopes, Carla; Maranga, Carina; Michael, Hayden; Rego, Ana Cristina. "Amelioration of ER stress and restauration of mitochondrial function contribute to the neuroprotective effects of pridopidine in HD neurons". Trabalho apresentado em 15th Annual Huntington’s disease Therapeutics Conference, 2020.
  10. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; da Rocha, Simão T; Fernandes, Tiago G.; Bekman, Evguenia; Cabral, Joaquim M.S. "Cerebellar organoids derived from human pluripotent stem cells to model Angelman Syndrome". Trabalho apresentado em 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies., 2019.
  11. Maranga, Carina; Silva, Teresa P.; Vaz, Sandra H.; da Rocha, Simão T; Fernandes, Tiago G.; Bekman, Evguenia; Cabral, Joaquim M.S. "Disease modeling of Angelman Syndrome using hiPSC-derived cerebellar organoids". Trabalho apresentado em XVI Meeting of the Portuguese Society for Neuroscience, 2019.
  12. Naia, Luana; Ly, P; Mota, Sandra I; Maranga, Carina; Lopes, Carla; Geva, M; Hayden, Michael R; Rego, A. Cristina. "Pridopidine preserves mitochondrial morphofunction in in vitro and ex vivo Huntington's models through sigma-1 receptor-dependent decrease in oxidative stress". Trabalho apresentado em The 14th International Conference on Alzheimers & Parkinsons Diseases, 2019.
  13. Geva, Michal; Naia, Luana; Ly, Phillip; Mota, Sandra; Lopes, Carla; Maranga, Carina; Hayden, Michael R; Rego, Ana Cristina. "Pridopidine rescues multiple mitochondrial functions impaired in human and mice HD models by activation of the Sigma-1 receptor". Trabalho apresentado em HSG 2019 – Huntington Study Group Annual Meeting, 2019.
  14. Ferreira, Ildete L; Maranga, Carina; Mota, Sandra I; Laço, Mário N; Sereno, José Vitor Oliveira; Abrunhosa, Antero; Hayden, Michael; Castelo-Branco, Miguel; Rego, A. Cristina. "Redox and mitochondrial function switches in striatum and cortex of pre-symptomatic and symptomatic Huntington's Disease mouse model". Trabalho apresentado em XIX National Congress of Biochemistry, 2016.
  15. Rego, A. Cristina; Maranga, Carina; Ferreira, Ildete L; Laço, Mário N; Mota, Sandra I; Naia, L; Sereno, José Vitor Oliveira; et al. "Redox changes and bioenergetic defects in striatum and and cortex of pre-symptomatic and symptomatic Huntington's Disease mice". Trabalho apresentado em Society for Neuroscience 46th annual meeting, 2016.
  16. Mota, Sandra I; Laço, Mário N; Rosa, Maura; Maranga, Carina; Ferreira, Ildete L; Rego, A. Cristina. "Age-dependent oxidative stress in presynaptic terminals of a mouse model of Huntington's Disease". Trabalho apresentado em 7th ISN Special Neurochemistry Conference, 2016.
  17. Maranga, Carina; Rosa, Maura; Laço, Mário N; Mota, Sandra I; Ferreira, Ildete L; Rego, A. Cristina. "Altered oxidative stress-related proteins in Huntington's Disease YAC128 mouse model". Trabalho apresentado em XIII CNC Anual Meeting, 2015.
  18. Laço, Mário N; Mota, Sandra I; Maranga, Carina; Ferreira, Ildete L; Rego, A. Cristina. "Redox deregulation in Huntington's Disease YAC128 transgenic mouse model is unrelated to mitochondrial dysfunction". Trabalho apresentado em XIII CNC Anual Meeting, 2015.
Tese / Dissertação
  1. Maranga, Carina Sofia Barradas. "Early mitochondrial modifications in YAC128 transgenic model of Huntington’s disease". Mestrado, 2016. http://hdl.handle.net/10316/33621.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/11/23 Brain-in-a-dish approach to model Angelman Syndrome Pitch Competition- PhD Open Days 2021
(Lisboa, Portugal)
2020/11 Brain-in-a-dish approach for studying Angelman Syndrome Pitch Competition- Phd Open Days 2020
Instituto Superior Técnico
2020/05 Angelman Syndrome: Clinical trials and Mini-brains Virtual meeting
Angel- Associação Síndrome de Angelman de Portugal (Portugal)
2020/02/05 Pridopidine rescues mitochondrial function in human and mouse Huntingtons disease models through Sigma-1 receptor 50th Meeting of Portuguese Pharmacology Society
Portuguese Pharmacology Society (Porto, Portugal)
2019/05/30 Disease modeling of Angelman Syndrome using hiPSC-derived cerebellar organoids XVI Meeting of the Portuguese Society for Neuroscience
Portuguese Society for Neuroscience (Lisboa, Portugal)
2017/03/15 Mitochondrial deregulation in striatum and cortex of pre-symptomatic and symptomatic Huntington's Disease mouse model SPDMov 2017 - "Care in Parkinson Disease"
Portuguese Society of Movement Disorders (SPDMov) (Offir, Portugal)
2016/06/04 Bioenergetic defects in pre-symptomatic and symptomatic stages in Huntington's disease YAC128 mouse model XXXth Meeting of study group on brain aging and dementia
Study group on brain aging and dementia (GEECD) (Lisboa, Portugal)
2016/02/04 Redox deregulation in pre-symptomatic and symptomatic stages of Huntington's Disease XLVI Annual Meeting of the Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Porto, Portugal)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/02/20 - 2022/02/20 Solidarity walk for Angelman Syndrome
Outro
 Walk'in ANGEL 2022
Angel - Associação Síndrome de Angelman de Portugal, Portugal
2021/12/03 - 2021/12/04 The 2021 FAST Global Summit & Gala
Conferência
 Fast forward together
Foundation for Angelman Syndrome Therapeutics, Estados Unidos
2021/09/24 - 2021/11/22 Writing in the Sciences. This course teaches scientists to become more effective writers, using practical examples and exercises.
Oficina (workshop)
 Writing in the Sciences course
Stanford University Department of Health Research and Policy, Estados Unidos
2020/12/04 - 2020/12/04 FAST Global Summit & Gala
Congresso
 Virtually Unstoppable
Foundation for Angelman Syndrome Therapeutics, Estados Unidos
2020/11/23 - 2020/11/23 Organoids With]Out[Borders
Simpósio
 Organoids With]Out[Borders
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/02/15 - 2020/02/15 Commemorative event for the international day of Angelman Syndrome with patients and families
Encontro
 15 de Fevereiro- International day of Angelman Syndrome
Angel - Associação Síndrome de Angelman de Portugal, Portugal
2019/04/09 - 2019/04/09 Neuroengineering | 3rd ed - Decoding Neural Information
Oficina (workshop)
 Neuroengineering | 3rd ed - Decoding Neural Information
Universidade do Porto, Portugal
2017/05/24 - 2017/05/24 Author Workshop by Anthony Newman, Senior publisher Elsevier Publishing Campus
Oficina (workshop)
 Author Workshop
Universidade de Coimbra, Portugal
2017/05/19 - 2017/05/19 How to structure data for statistical analysis?
Oficina (workshop)
 How to structure data for statistical analysis?
Universidade de Coimbra, Portugal

Laboratório de Bioestatística e Informação médica (LBIM), Portugal
2017/04/28 - 2017/04/28 How to choose the most appropriate statistical technique?
Oficina (workshop)
 How to choose the most appropriate statistical technique?
Universidade de Coimbra, Portugal

Laboratório de Bioestatística e Informação médica (LBIM), Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021/05/10 - 2021/05/10 Lecture on Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids for the Biology and Stem Cell Technology Module Evolutionary and Developmental Biology; Genetic and Molecular Biology (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2020/05/07 - 2020/05/07 Lecture on Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids for the Biology and Stem Cell Technology Module Evolutionary and Developmental Biology; Genetic and Molecular Biology (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019/05/07 - 2019/05/07 Lecture on Disease modeling of Angelman syndrome using hiPSC-derived cerebellar organoids for the Biology and Stem Cell Technology Module Evolutionary and Developmental Biology; Genetic and Molecular Biology (Mestrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Membro de associação

Nome da associação Tipo de participação
2019 - Atual Portuguese Society of Stem cells and Cell therapies
2019 - Atual Portuguese Society for Neuroscience
Distinções

Prémio

2022 Registration Grant - 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies 2022
Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2021 Registration Grant - XVII Meeting of the Portuguese Society for Neuroscience
2020 EMBL Corporate Partnership Programme Registration Fee Waiver
European Molecular Biology Organization , Alemanha
2019 Registration Grant - 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies 2019
Portuguese Society for Stem Cells and Cell Therapies, Portugal