Ligia M Saraiva (821D-BBFC-F470)

Curriculum Vitae

Ligia M Saraiva

Lígia M. Saraiva is a Full Professor in Biochemistry in ITQB-NOVA. She leads the Molecular Mechanisms of Pathogen Resistance Lab that has as main focus to study the Survival Mechanisms of Human Pathogens, by investigating the following areas: i) Microbial Heme Biosynthesis; ii); bacterial defenses against Oxidative and Nitrosative Stress imposed by the innate immune system, and iii) development of Carbon Monoxide Releasing Compounds (CORMs) as new antimicrobials. The research aims at characterizing microbial phenotypes under stress conditions and deciphering the role of genes/proteins in specific bacterial metabolisms, using a multidisciplinary approach encompassing molecular genetics, microbiology, and biochemistry. She has authored over 130 articles in international journals and holds 2 registered patents (Google Scholar: H-index 41, citations >5200). Over the years, she has supervised 14 PhD theses and has been involved as a Principal Investigator or co-PI in more than 25 research projects.

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Identificação

Identificação pessoal

Nome completo: Ligia M Saraiva

Nomes de citação

Saraiva, Ligia M

Identificadores de autor

Ciência ID: 821D-BBFC-F470
ORCID iD: 0000-0002-0675-129X
Google Scholar ID: https://scholar.google.com/citations?user=HBdOMucAAAAJ&hl=en
Researcher Id: H-8537-2012
Scopus Author Id: 7005249012

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)

Formação

	Grau	Classificação
2011/06/05 Concluído	Microbial Physiology (Título de Agregado) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
1993 Concluído	Bioquímica (Doutoramento) Especialização em Especialidade: Bioquímica Física Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Citocromos de Bactérias Desnitrificantes - Análise Bioquímica e Espectroscópica" (TESE/DISSERTAÇÃO)
1987/12/30 Concluído	Engenharia Química (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2004/01/02 - 2020/09/01	Investigador principal (carreira) (Investigação)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2020/10/01 - Atual	Professor Catedrático (Docente Universitário)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2018/06 - Atual	Member of General Council	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa, Portugal
2018 - 2019	Member of General Council	Universidade Nova de Lisboa, Portugal
	Universidade Nova de Lisboa, Portugal

Projetos

Projeto

	Designação	Financiadores
2021/01/01 - 2025/12/31	Life Sciences for a Healthy and Sustainable Future LA/P/0087/2020 10.54499/LA/P/0087/2020 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal Instituto Gulbenkian de Ciência, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal Universidade de Lisboa Centro de Estudos Comparatistas, Portugal BioResources 4 Sustainability, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022/01/01 - 2024/12/31	Interaction of RIC with iron-sulfur biogenesis systems FCT PTDC/BIA- MIC/0268/2021 Investigador responsável Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia
2022/01/01 - 2024/12/31	Interaction of RIC with iron-sulfur biogenesis systems PTDC/BIA-MIC/0268/2021 10.54499/PTDC/BIA-MIC/0268/2021 Universidade Nova de Lisboa, Portugal BioResources 4 Sustainability, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022/01/01 - 2024/12/31	Interaction of RIC with iron-sulfur biogenesis systems PTDC/BIA-MIC/0268/2021 10.54499/PTDC/BIA-MIC/0268/2021 Universidade Nova de Lisboa, Portugal BioResources 4 Sustainability, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022/01 - 2024/12	Interaction of RIC with iron-sulfur biogenesis systems FCT PTDC/BIA- MIC/0268/2021	Fundação para a Ciência e a Tecnologia
2022/01/01 - 2023/12/31	Metabolomics for the Identification of Biomarkers for Early Diagnosis of Lower Respiratory Tract Infections EXPL/BTM-TEC/1019/2021 10.54499/EXPL/BTM-TEC/1019/2021 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Centro Hospitalar Universitário de Santo António, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2021/04/01 - 2023/03/31	Novel Strategy to cope with Multidrug Resistant Pathogens 101003441 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Em curso
2018/10/01 - 2022/09/30	Diversity and complexity of microbial multidomain oxygen and/or nitric oxide reductases flavodiiron enzymes from Clostridiales PTDC/BIA-BQM/27959/2017 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/10/01 - 2022/09/30	Role of bacterial haem biosynthesis in host-pathogen interaction PTDC/BIA-BQM/28642/2017 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/10/01 - 2022/09/30	Staphylococcus epidermidis adaptation to nitric oxide produced by the innate immune system PTDC/BIA-MIC/31566/2017 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/10/01 - 2022/04/30	Exploring the Antimicrobial Potential of Carbon Monoxide-Releasing Molecules PTDC/SAU-INF/29313/2017 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2018/10/01 - 2021/10/01	The role of heme bacterial biosynthesis in pathogen-host interaction FCT-PTDC/BIA-BQM/28642/2017 Investigador responsável Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Em curso
2018/10/01 - 2021/10/01	Exploring the Antimicrobial Potential of Carbon-Monoxide-Releasing-Molecules PTDC/SAU-INF/29313/2017 Investigador Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Em curso
2018/10/01 - 2021/10/01	Adaptation of Staphylococcus epidermidis to stress imposed by the innate immune system FCT-PTDC/BIA-MIC/31566/2017 Investigador Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Em curso
2018/10 - 2021/10	The role of heme bacterial biosynthesis in pathogen-host interaction FCT-PTDC/BIA-BQM/28642/2017	N/A
2018/10 - 2021/10	Adaptation of Staphylococcus epidermidis to stress imposed by the innate immune system FCT-PTDC/BIA-MIC/31566/2017	N/A
2018/10/01 - 2021/09/30	Exploring the Antimicrobial Potential of Carbon Monoxide-Releasing Molecules PTDC/SAU-INF/29313/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/10/01 - 2021/09/30	Role of bacterial haem biosynthesis in host-pathogen interaction PTDC/BIA-BQM/28642/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/10/01 - 2021/09/30	Staphylococcus epidermidis adaptation to nitric oxide produced by the innate immune system PTDC/BIA-MIC/31566/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/10/01 - 2021/09/30	Exploring the Antimicrobial Potential of Carbon Monoxide-Releasing Molecules PTDC/SAU-INF/29313/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/10/01 - 2021/09/30	Role of bacterial haem biosynthesis in host-pathogen interaction PTDC/BIA-BQM/28642/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/10/01 - 2021/09/30	Staphylococcus epidermidis adaptation to nitric oxide produced by the innate immune system PTDC/BIA-MIC/31566/2017 Universidade Nova de Lisboa, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018/09/01 - 2021/09/01	Twin to Illuminate Metals in Biology and Biocatalysis through Biospectroscopy. Widespread Twinning Action Horizon 2020. Widespread Twinning Action Horizon 2020. Investigador	Em curso
2019/01/01 - 2019/12/31	Molecular, Structural and Cellular Microbiology UID/CBQ/04612/2019 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2019/01/01 - 2019/12/31	Microbiologia Molecular, Estrutural e Celular UID/CBQ/04612/2019 Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/05/01 - 2019/10/31	Diiron proteins in the microbial response to oxidative or nitrosative stress PTDC/BBB-BQB/3135/2014 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal BioResources 4 Sustainability, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/05/01 - 2019/08/31	Biosynthesis of modified tetrapyrroles in Staphyloccocus aureus PTDC/BBB-BQB/5069/2014 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/05/01 - 2019/08/31	Biosynthesis of modified tetrapyrroles in Staphyloccocus aureus PTDC/BBB-BQB/5069/2014 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/05/01 - 2019/08/31	Biosynthesis of modified tetrapyrroles in Staphyloccocus aureus PTDC/BBB-BQB/5069/2014 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2015/09/01 - 2018/09/01	Diiron proteins in the microbial response to oxidative or nitrosative stress. FCT-PTDC/BBB-BQB/3135/2014. Investigador responsável	Concluído
2015/09 - 2018/09	Diiron proteins in the microbial response to oxidative or nitrosative stress. FCT-PTDC/BBB-BQB/3135/2014.	N/A
2013/07/01 - 2015/09/30	Heme biosynthesis in Staphylococcus aureus:old bug new challenges PTDC/BBB-BQB/0937/2012 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/07/01 - 2015/09/30	Heme biosynthesis in Staphylococcus aureus:old bug new challenges PTDC/BBB-BQB/0937/2012 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/07/01 - 2015/09/30	Heme biosynthesis in Staphylococcus aureus:old bug new challenges PTDC/BBB-BQB/0937/2012 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/09/01 - 2015/09/01	Heme biosynthesis in Staphylococcus aureus: old bug new challenges FCT-PTDC/BBB-BQB/0937/2012 Investigador responsável Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Concluído
2013/09 - 2015/09	Heme biosynthesis in Staphylococcus aureus: old bug new challenges FCT-PTDC/BBB-BQB/0937/2012	N/A
2010/01/01 - 2013/06/30	Functional study of a diiron protein with the unique role of repairing iron-sulphur clusters PTDC/BIA-PRO/098224/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/01/01 - 2013/06/30	Unraveling the mechanisms of nitrosative stress resistance of Helicobacter pylori: relevance for immune subversion and infectiousness PTDC/SAU-MII/098086/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/01/01 - 2013/06/30	Functional study of a diiron protein with the unique role of repairing iron-sulphur clusters PTDC/BIA-PRO/098224/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/01/01 - 2013/06/30	Unraveling the mechanisms of nitrosative stress resistance of Helicobacter pylori: relevance for immune subversion and infectiousness PTDC/SAU-MII/098086/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/01/01 - 2013/06/30	Functional study of a diiron protein with the unique role of repairing iron-sulphur clusters PTDC/BIA-PRO/098224/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010/01/01 - 2013/06/30	Unraveling the mechanisms of nitrosative stress resistance of Helicobacter pylori: relevance for immune subversion and infectiousness PTDC/SAU-MII/098086/2008 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Institut Pasteur, França	Fundação para a Ciência e a Tecnologia Concluído
2011/01/01 - 2012/12/31	Strategic Project - LA 4 - 2011-2012 PEst-OE/EQB/LA0004/2011 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Universidade NOVA de Lisboa NOVA Medical School, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Instituto de Biologia Experimental e Tecnológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009/01/01 - 2012/12/31	Investigation of redox-state-specific protein-protein interactions and energy transduction in the electron transfer chains of sulfate reducing bacteria PTDC/QUI/65640/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/01/01 - 2011/12/31	Identification and characterization of the supercomplexes from the bacterial aerobic respiratory chain of Escherichia coli and Bacillus subtilis PTDC/BIA-PRO/67105/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Instituto de Investigação Científica Tropical, Portugal Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/01/01 - 2011/11/30	Microbial enzymes involved in superoxide and nitric oxide reduction PTDC/BIA-PRO/67263/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/01/01 - 2011/11/30	Microbial enzymes involved in superoxide and nitric oxide reduction PTDC/BIA-PRO/67263/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/01/01 - 2011/11/30	Microbial enzymes involved in superoxide and nitric oxide reduction PTDC/BIA-PRO/67263/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/01/01 - 2011/03/31	Iron Metabolism Study in Deinococcus radiodurans- Novel strategies PTDC/BIA-PRO/67240/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal Universidade de Lisboa Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/01/01 - 2011/02/28	Quinol oxidation by membrane cytochromes c widely implicated in bacterial respiration - structural studies of the model NrfHA complex PTDC/BIA-PRO/68486/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/01/01 - 2011/02/28	Quinol oxidation by membrane cytochromes c widely implicated in bacterial respiration - structural studies of the model NrfHA complex PTDC/BIA-PRO/68486/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/01/01 - 2011/02/28	Quinol oxidation by membrane cytochromes c widely implicated in bacterial respiration - structural studies of the model NrfHA complex PTDC/BIA-PRO/68486/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/02/01 - 2011/01/31	Iron metabolism in sulphate reducing bacteria PTDC/BIA-PRO/67107/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/02/01 - 2011/01/31	Iron metabolism in sulphate reducing bacteria PTDC/BIA-PRO/67107/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/02/01 - 2011/01/31	Iron metabolism in sulphate reducing bacteria PTDC/BIA-PRO/67107/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/11/12 - 2010/12/31	Understanding sulfate respiration at molecular level: studies of two conserved membrane complexes PTDC/QUI/68368/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/11/12 - 2010/12/31	Understanding sulfate respiration at molecular level: studies of two conserved membrane complexes PTDC/QUI/68368/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007/11/12 - 2010/12/31	Understanding sulfate respiration at molecular level: studies of two conserved membrane complexes PTDC/QUI/68368/2006 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/09/01 - 2008/03/31	Nitrosative Stress Responses of Human Pathogens POCI/SAU-IMI/56088/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/09/01 - 2008/03/31	Nitrosative Stress Responses of Human Pathogens POCI/SAU-IMI/56088/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/09/01 - 2008/03/31	Nitrosative Stress Responses of Human Pathogens POCI/SAU-IMI/56088/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/09/01 - 2007/06/30	Characterisation of a membrane bound cytochrome involved in the anaerobic respiration in Sulfate Reducing Bacteria POCI/QUI/55690/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/09/01 - 2007/06/30	Characterisation of a membrane bound cytochrome involved in the anaerobic respiration in Sulfate Reducing Bacteria POCI/QUI/55690/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/09/01 - 2007/06/30	Characterisation of a membrane bound cytochrome involved in the anaerobic respiration in Sulfate Reducing Bacteria POCI/QUI/55690/2004 Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em conferência	Todorovic, S.; Nobre, L.S.; Tavares, A.F.N.; Hildebrandt, P.; Teixeira, M.S.; Saraiva, L.M.. "Disentangling interactions of an azole antibiotic with a flavohemoglobin from S. aureus". 2010. 10.1063/1.3482863
Artigo em revista	Saraiva, Ligia M; Liliana S. O. Silva; Lourenço, Frederico; Mafalda R. Almeida. Autor correspondente: Saraiva, Ligia M. "Structural basis of Escherichia coli YtfE iron donor properties". Encyclopedia of Inorganic and Bioinorganic Chemistry (2023): No prelo Jordi Zamarreño Beas1, Marco A.M. Videira1, Val Karavaeva2, Frederico S. Lourenço1, Mafalda R. Almeida1, Filipa Sousa2, . Autor correspondente: Jordi Zamarreño Beas1, Marco A.M. Videira1, Val Karavaeva2, Frederico S. Lourenço1, Mafalda R. Almeida1, Filipa Sousa2,. "In Campylobacter jejuni a new type of chaperone receives heme b from ferrochelatase". BIORXIV/2023/534706 (2023): Publicado Oliveira, Ana S.; Saraiva, Lígia M.; Carvalho, Sandra M.. "Staphylococcus epidermidis biofilms undergo metabolic and matrix remodeling under nitrosative stress". (2023): http://hdl.handle.net/10362/158524. https://doi.org/10.3389/fcimb.2023.1200923 Zamarreño Beas, Jordi; Videira, Marco A.M.; Karavaeva, Val; Lourenço, Frederico M.; Almeida, Mafalda R.; Sousa, Filipa; Saraiva, Lígia M.. "In Campylobacter jejuni, a new type of chaperone receives heme from ferrochelatase". (2023): http://hdl.handle.net/10362/158523. https://doi.org/10.3389/fgene.2023.1199357 Liliana S. O. Silva; Pedro M. Matias; Célia V. Romão; Lígia M. Saraiva. "Repair of Iron Center Proteins—A Different Class of Hemerythrin-like Proteins". Molecules 27 13 (2022): 4051-4051. https://doi.org/10.3390/molecules27134051. 10.3390/molecules27134051 Mendes, Sofia S.; Marques, Joana; Mesterházy, Edit; Straetener, Jan; Arts, Melina; Pissarro, Teresa; Reginold, Jorgina; et al. "Synergetic Antimicrobial Activity and Mechanism of Clotrimazole-Linked CO-Releasing Molecules". ACS Bio & Med Chem Au 2 4 (2022): 419-436. http://dx.doi.org/10.1021/acsbiomedchemau.2c00007. 10.1021/acsbiomedchemau.2c00007 Zamarreño Beas, Jordi; Videira, Marco A.M.; Saraiva, Lígia M.. "Regulation of bacterial haem biosynthesis". Coordination Chemistry Reviews 452 (2022): 214286. http://dx.doi.org/10.1016/j.ccr.2021.214286. 10.1016/j.ccr.2021.214286 Sandra M Carvalho; Cláudia S Freitas; Ana S Oliveira; Lígia M Saraiva. "Staphylococcus aureus flavohaemoglobin contributes to early stage biofilm development under nitrosative stress". FEMS Microbiology Letters 368 18 (2021): https://doi.org/10.1093/femsle/fnab131. 10.1093/femsle/fnab131 Sofia S. Mendes; Vanessa Miranda; Lígia M. Saraiva. "Hydrogen Sulfide and Carbon Monoxide Tolerance in Bacteria". Antioxidants (2021): https://doi.org/10.3390/antiox10050729. 10.3390/antiox10050729 Carvalho, Sandra M.; Freitas, Cláudia S.; Oliveira, Ana S.; Saraiva, Lígia M.. "Staphylococcus aureus flavohaemoglobin contributes to early stage biofilm development under nitrosative stress". (2021): http://hdl.handle.net/10362/142212. https://doi.org/10.1093/femsle/fnab131 Silva, Liliana S.O.; Matias, Pedro M.; Romão, Célia V.; Saraiva, Lígia M.. "Structural Basis of RICs Iron Donation for Iron-Sulfur Cluster Biogenesis". (2021): http://hdl.handle.net/10362/128785. https://doi.org/10.3389/fmicb.2021.670681 Apura, Patrícia; Saramago, Margarida; Peregrina, Alexandra; Viegas, Sandra C.; Carvalho, Sandra Margarida; Saraiva, Ligia M; Arraiano, Cecília M.; Domingues, Susana. Autor correspondente: Domingues, Susana. "Tailor-made sRNAs: a plasmid tool to control the expression of target mRNAs in Pseudomonas putida". Plasmid 109 (2020): 102503. http://dx.doi.org/10.1016/j.plasmid.2020.102503. Publicado • 10.1016/j.plasmid.2020.102503 Apura, Patrícia; Saramago, Margarida; Peregrina, Alexandra; Viegas, Sandra C.; Carvalho, Sandra M.; Saraiva, Lígia M.; Arraiano, Cecília M.; Domingues, Susana. "Tailor-made sRNAs". (2020): http://hdl.handle.net/10362/128317. https://doi.org/10.1016/j.plasmid.2020.102503 Videira, Marco A.M.; Lobo, Susana A.L.; Sousa, Filipa L.; Saraiva, Lígia M.. "Identification of the sirohaem biosynthesis pathway in Staphylococcus aureus". (2020): http://hdl.handle.net/10362/91636. https://doi.org/10.1111/febs.15091 Marco A. M. Videira; Susana A. L. Lobo; Filipa L. Sousa; Lígia M. Saraiva. "Identification of the sirohaem biosynthesis pathway in Staphylococcus aureus". The FEBS Journal (2019): https://doi.org/10.1111/febs.15091. 10.1111/febs.15091 Borges, P.T.; Romão, C.V.; Saraiva, L.M.; Gonçalves, V.L.; Carrondo, M.A.; Teixeira, M.; Frazão, C.. "Analysis of a new flavodiiron core structural arrangement in Flv1-¿FlR protein from Synechocystis sp. PCC6803". 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"Characterization of the dihemic cytochrome C549from the marine denitrifying bacterium pseudomonas nautica 617". Biochemical and Biophysical Research Communications 199 3 (1994): 1289-1296. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028291355&partnerID=MN8TOARS. 10.1006/bbrc.1994.1371 Saraiva, L.M.; Thomson, A.J.; Lebrun, N.E.; Liu, M.Y.; Payne, W.J.; Legall, J.; Moura, I.. "Replacement of Methionine as the Axial Ligand of Achromobacter cycloclastes Cytochrome C554at High pH Values Revealed by Absorption, EPR and MCD Spectroscopy". Biochemical and Biophysical Research Communications 204 1 (1994): 120-128. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028019788&partnerID=MN8TOARS. 10.1006/bbrc.1994.2434 Saraiva, L.M.; Fauque, G.; Besson, S.; Moura, I.. "Physico-chemical and Spectroscopic Properties of the Monohemic Cytochrome C552 from Pseudomonas nautica 617". 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Capítulo de livro	Carvalho, Sandra M.; Beas, Jordi Zamarreño; Videira, Marco A.M.; Saraiva, Lígia M.. "Defenses of multidrug resistant pathogens against reactive nitrogen species produced in infected hosts". In Advances in Microbial Physiology, 85-155. Elsevier, 2022. 10.1016/bs.ampbs.2022.02.001
Livro	Nobre, L.S.; Saraiva, L.M.. Di-iron RICs: Players in Nitrosative-oxidative Stress Defences. 2016. 10.1002/9781119004813.ch96 Lobo, S.A.L.; Warren, M.J.; Saraiva, L.M.. Sulfate-Reducing Bacteria Reveal a New Branch of Tetrapyrrole Metabolism. 2012. 10.1016/B978-0-12-394423-8.00007-X Vicente, J.B.; Justino, M.C.; Gonçalves, V.L.; Saraiva, L.M.; Teixeira, M.. Biochemical, Spectroscopic, and Thermodynamic Properties of Flavodiiron Proteins. 2008. 10.1016/S0076-6879(07)37002-X Nobre, L.S.; Gonçalves, V.L.; Saraiva, L.M.. Flavohemoglobin of Staphylococcus aureus. 2008. 10.1016/S0076-6879(08)36011-X Saraiva, L.M.; Vicente, J.B.; Teixeira, M.. The role of the flavodiiron proteins in microbial nitric oxide detoxification. 2004. 10.1016/S0065-2911(04)49002-X
Poster em conferência	Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. Autor correspondente: Carvalho, Sandra Margarida. "Staphylococcus epidermidis biofilm metabolism and matrix remodelling promotes resistance to nitrosative stress". Trabalho apresentado em 13th ITQB NOVA PhD Students' Meeting, October 18-20, 2023, Oeiras, Portugal, 2023. Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. Autor correspondente: Carvalho, Sandra Margarida. "Strategies of Staphylococcus epidermidis biofilms to survive nitric oxide produced by immune cells". Trabalho apresentado em New approaches and concepts in microbiology, June 27-30, 2023, Heidelberg, Germany, 2023. Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. "Study of the metabolic adaptation of Staphylococcus epidermidis biofilms to nitrosative stress". Trabalho apresentado em Twin to illuminate metal in biology and biocatalysis through biospectroscopy (TIMB3), Tomar, Portugal, 2022. Carvalho, Sandra Margarida; Cruz, Hugo; Ana Santos Oliveira; Saraiva, Ligia M. "Untargeted 1H-NMR metabolomics of bronchoalveolar lavages fluids for biomarker discovery for respiratory tract infectious diseases". Trabalho apresentado em Twin to illuminate metal in biology and biocatalysis through biospectroscopy (TIMB3), Tomar, Portugal, 2022. Ana Santos Oliveira; Cruz, Hugo; Saraiva, Ligia M; Carvalho, Sandra Margarida. Autor correspondente: Carvalho, Sandra Margarida. "Uncovering bronchoalveolar lavage fluids biomarkers for diagnosis of lower respiratory tract infectious agents". Trabalho apresentado em 18th International Conference of the Metabolomics Society, Metabolomics 22, Valência, Spain, 2022. Zamarreno Beas, Jordi; Videira, Marco A.M; Batista, Joana; Saraiva, Ligia M. "Haem biosynthesis in Gram-negative pathogens". Trabalho apresentado em Microbiotec21, 2021. Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. "Insights into the adaptation of Staphylococcus epidermidis biofilms to effectors of the immune system". Trabalho apresentado em Microbiotech, online, Portugal, 2021. Zamarreno Beas, Jordi; Videira, Marco A.M; Batista, Joana; Saraiva, Ligia M. Autor correspondente: Saraiva, Ligia M. "Study of haem biosynthesis in multidrug resistant pathogens". Trabalho apresentado em IV International Conference NOVAhealth Chronic Disease and Infection, 2021. Ana Santos Oliveira; Saraiva, Ligia M; Carvalho, Sandra Margarida. "A glimpse into the phenotypic adaptation of Staphylococcus epidermidis biofilms to nitrosative stress". Trabalho apresentado em IV International Conference NOVAhealth Chronic Disease and Infection, Lisbon, Portugal, 2021. Zamarreno Beas, Jordi; Videira, Marco A.M; Batista, Joana; Saraiva, Ligia M. Autor correspondente: Saraiva, Ligia M. "Haem biosynthesis in Campylobacter jejuni". Trabalho apresentado em NOVAhealth Chronic Disease and Infection: Infection, Cancer and Global Health, 2020. Apura P; Peregrina A; Viegas, SC; Saramago, Margarida; Carvalho, Sandra Margarida; Saraiva, Ligia M; Domingues SM; Arraiano CM. "Small noncoding RNAs as a tool to modulate gene expression". Trabalho apresentado em 6th Joint Conference of the DGHM & VAAM, Leipzig, 2020. Carvalho, Sandra Margarida; Freitas, CS; kuipers OP; Saraiva, Ligia M. "Metabolic adaptation of Staphylococcus aureus to antimicrobial nitrosative stress imposed by host innate immunity". Trabalho apresentado em Microbiotech, Coimbra, Portugal, 2019. Carvalho, Sandra Margarida; Marques J; Carlos C. Romão; Saraiva, Ligia M. "Using metabolomics to assess the effect of the antimicrobial carbon monoxide-releasing molecule-3 in Escherichia coli central metabolic enzymes.". Trabalho apresentado em Microbiotech, Coimbra, Portugal, 2019. Carvalho, Sandra Margarida; Freitas, CS; Saraiva, Ligia M. "Staphylococcus epidermidis - coping with the host immune system". Trabalho apresentado em Microbiotech, Coimbra, Portugal, 2019. Zamarreno Beas, Jordi; Batista, Joana; Videira, Marco A.M; Saraiva, Ligia M. "Haem metabolism in human pathogens". Trabalho apresentado em Microbiotec19, 2019. Mendes SS; Carvalho, Sandra Margarida; Mesterhazy E; Romão CC; Saraiva, Ligia M. "Development of novel antimicrobial carbon monoxide-releasing molecules and insights into their mechanism of action". Trabalho apresentado em 1st TIMB3 Annual Meeting, Carcavelos, Portugal, 2019. 10.1158/1538-7445.am2019-2077 Videira, Marco André Moras; Lobo, Susana A.L.; Silva, Liliana S.O; David J. Palmer; Warren, Martin J; Coutinho, Ana; Sousa, Filipa L; Fernandes, Fábio; Saraiva, Ligia M. "Control of heme homeostasis in Staphylococcus aureus". Trabalho apresentado em Gordon Research Conference on Cell Biology of Metals, 2019. Carvalho, Sandra Margarida; Kuipers, Oscar Paul; Saraiva, Ligia M. "Staphylococcus aureus a-acetolactate synthase ALS confers resistance to nitrosative stress imposed by host innate immunity". Trabalho apresentado em IV Genetics Workshop, Lisbon, Portugal, 2019. Videira, Marco André Moras; Lobo, Susana A.L; Silva, Liliana S.O; Warren, Martin J; Coutinho, Ana; Sousa, Filipa L; Fernandes, Fábio; Saraiva, Ligia M. "Staphylococcus aureus intracellular haem levels are controlled by a link between ferrochelatase and a haem monooxygenase enzyme". Trabalho apresentado em IV Genetics Workshop, 2019. Carvalho, Sandra Margarida; Saraiva, Ligia M. "Intracellular targets of the antimicrobial CORM-3 analyzed by NMR and Mass Spectrometry Metabolomics". Trabalho apresentado em Twin to illuminate metals in biology and biocatalysis through Biospectroscopy, TIMB3, kick-off meeting, Sintra, Portugal, 2018. Carvalho, Sandra Margarida; Freitas, CS; Kuipers OP; Saraiva, Ligia M. "Staphylococcus aureus metabolic strategies to survive nitrosative stress". Trabalho apresentado em 19th Biennial Meeting of Society for Free Radical Research International (SFRRI), Lisbon, Portugal., 2018. Carvalho, Sandra Margarida; Romão CC; Kuipers OP; Saraiva, Ligia M. "Insights into the action of carbon monoxide on Staphylococcus aureus". Trabalho apresentado em 3th International Conference Pathophysiology of Staphylococci, Tubingen, Germany, 2016. Videira, Marco A.M; Lobo, Susana A.L; Scott, Alan; Warren, Martin J; Saraiva, Ligia M. "Haem biosynthetic pathway in Staphylococcus aureus". Trabalho apresentado em 6th ITQB NOVA PhD Student´s Meeting, 2015. Carvalho, Sandra Margarida; Kuipers OP; Saraiva, Ligia M. "The effect of carbon monoxide on the human pathogen Staphylococcus aureus". Trabalho apresentado em Bacterial Electron Transfer Processes and Their Regulation, Vimeiro, Portugal., 2015.
Pré-impressão	Jordi Zamarreño Beas; Marco A.M. Videira; Val Karavaeva; Frederico S. Lourenço; Mafalda R. Almeida; Filipa Sousa; Lígia M. Saraiva. "InCampylobacter jejunia new type of chaperone receives hemebfrom ferrochelatase". 2023. https://doi.org/10.1101/2023.03.30.534706. 10.1101/2023.03.30.534706
Revisão de livro	Mendes, Sofia S.; Miranda, Vanessa; Saraiva, Lígia M.. "Hydrogen sulfide and carbon monoxide tolerance in bacteria". http://hdl.handle.net/10362/128802. https://doi.org/10.3390/antiox10050729 Zamarreño Beas, Jordi; Videira, Marco A.M.; Saraiva, Lígia M.. "Regulation of bacterial haem biosynthesis". http://hdl.handle.net/10362/153047. https://doi.org/10.1016/j.ccr.2021.214286
Tese / Dissertação	Oliveira, Ana Rita Santos. "Understanding how Staphylococcus epidermidis adapts to nitrosative stress generated by the cells of innate immunity". Mestrado, 2021. http://hdl.handle.net/10362/111471. Oliveira, Ana Rita Santos. "Understanding how Staphylococcus epidermidis adapts to nitrosative stress generated by the cells of innate immunity". Mestrado, 2021. http://hdl.handle.net/10362/111471. Amorim, André Ricardo Barreiro. "Influence of the nir operon in the adaptation of Staphylococcus aureus to the host environment". Mestrado, 2019. http://hdl.handle.net/10773/27763. Videira, Marco A.M. "Staphylococcus aureus: the paths and crosstalks that lead to heme". Doutoramento, 2018. http://hdl.handle.net/10362/93875. Parente, Adelina Margarida Lima Pereira Rodrigues. "Defences of Helicobacter species against host antimicrobials". Doutoramento, 2016. http://hdl.handle.net/10362/51886. Santos, Inês Henriques dos. "Estudo do regulador SrrAB do Staphylococcus aureus". Mestrado, 2014. http://hdl.handle.net/10451/15787. Santos, Inês Henriques dos. "Estudo do regulador SrrAB do Staphylococcus aureus". Mestrado, 2014. http://hdl.handle.net/10451/15787. Figueiredo, Mafalda Cristina de Oliveira. "Desulfovibrio vulgaris defenses against oxidative and nitrosative stresses". Doutoramento, 2013. http://hdl.handle.net/10362/10883. Tavares, Ana Filipa Nogueira. "Novel insights into the action of antimicrobial agents against human pathogens". Doutoramento, 2013. http://hdl.handle.net/10362/11965. Ribeiro, Cláudia Azevedo, 1988-. "Estudo da utilização do hemo em Staphilococcus aureus". Mestrado, 2013. http://hdl.handle.net/10451/9443. Figueiredo, Mafalda Cristina de Oliveira. "Desulfovibrio vulgaris defenses against oxidative and nitrosative stresses". Doutoramento, 2013. http://hdl.handle.net/10362/10883. Godinho, Catarina Sofia Caetano. "Estudo do gene ric de staphylococcus aureus". Mestrado, 2012. http://hdl.handle.net/10451/9273. Baptista, Joana Morais. "The role of Di-iron proteins in pathogen resistance". Doutoramento, 2012. http://hdl.handle.net/10362/8583. Godinho, Catarina Sofia Caetano. "Estudo do gene ric de staphylococcus aureus". Mestrado, 2012. http://hdl.handle.net/10451/9273. Godinho, Catarina Sofia Caetano. "Estudo do gene ric de staphylococcus aureus". Mestrado, 2012. http://hdl.handle.net/10451/9273. Pereira, Fábio Alexandre Paulino; Sobral, Luís Miguel da Silva. "Estudo das "Hybrid Cluster Proteins" de Desulfovibrio vulgaris Hildenborough". Mestrado, 2012. http://hdl.handle.net/10451/8886. Venceslau, Sofia Cristina dos Santos. "Electron transfer chains in sulfate reducing bacteria". Doutoramento, 2011. http://hdl.handle.net/10362/9779. Nobre, Lígia S.. "Unravelling novel modes of antimicrobial action". Doutoramento, 2010. http://hdl.handle.net/10362/5156. Lobo, Susana André. "Anaerobic bacteria: an investigation of metabolic important enzymes: a novel type of oxygen reductase and enzymes of the tetrapyrrole biosynthesis". Doutoramento, 2009. http://hdl.handle.net/10362/4082.

Propriedade Intelectual

Patente

Saraiva, Ligia. 2018. "Lígia S. Nobre, Joao Seixas, Carlos Romão, and Lígia M. Saraiva. (2008) Treatment of infections by carbon monoxide. International A". Estados Unidos.
Expirada

Outros

Outra produção

A formação docente na perspectiva da inclusão: Científico. Made available in DSpace on 2016-06-28T17:32:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2007. Added 1 bitstream(s) on 2016-06-28T17:40:31Z : No. of bitstreams: 1 ISBN9788561134006-2007-1-179.pdf: 768230 bytes, checksum: 0e3191a9bd075639741b928fa759fb67 (MD5). Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Universidade Federal de São Carlos (UFSCar), Centro de Educação e C. 2016. Veltrone, Aline Aparecida; Mendes, Enicéia Gonçalves; Saraiva, Ana Cláudia Lopes Chequer; Vicente, Carla Cristina; Ferenc, Alvanize Valente Fernandes; Rossi, Célia Regina [UNESP]; Pedroso, Cristina Cinto Araújo; et al. http://hdl.handle.net/11449/140051.
Functionalized protein nanoemulsions by incorporation of chemically modified BSA. The incorporation of bioactive compounds in stealth nanoparticles or nanoemulsions enhances their half-life in systemic circulation and can overcome the problems associated with the free drug. Bovine serum albumin (BSA)-drug conjugates were produced with either methotrexate (MTX), a potent anticancer agent, or vancomycin (VCM), a potent antibiotic. Those conjugates were used to produce functionali. 2015. Loureiro, Ana; Abreu, Ana S.; Sárria, M. P.; Figueiredo, Mafalda C. O.; Saraiva, Lígia M.; Bernardes, Gonçalo J. L.; Gomes, Andreia; Paulo, Artur Cavaco. http://hdl.handle.net/1822/34795.
10.1039/C4RA13802C

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2006/01/01	40 oral presentations at International meetings . Poster presentation 185 in national and international meetings.

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2004/01/01 - Atual	Supervision of 12 Postdocs- 2 ongoing. Supervision of 12 PhD (see PhD thesis) - 2 ongoing. Supervision 27 Master students - 2 ongoing Orientador

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2021 - Atual	Frontiers in Cellular and Infection Microbiology Editorial Board	Frontiers
2017/01/01 - Atual	Frontiers in Microbiology Editorial Board (1664-302X)	Frontiers Media SA
2012/01/01 - Atual	FEMS Microbiology Letters Editorial Board (1574-6968)	Oxford University Press
2012/01/01 - Atual	PLoS ONE Editorial Board (1932-6203)	Public Library of Science
2012/01/01 - Atual	The Open Microbiology Journal Editorial Board (1874-2858)	Bentham Science

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2012/01/01 - Atual	Grant Evaluator of :Fonds de la Recherche Scientifique. Belgium. Austrian Science Foundation, Fundo Regional para a Ciência e Tecnologia, Açores. Agence Nationale de la Recherche. France. Fundação para a Ciência e Tecnologia, Portugal. Biotechnology and Biological Sciences Research Council, United Kindgom. British Society for Antimicrobial Therapy. Vice- Chair and Chair of Marie Sklodowska-Curie Individual Fellowships and Spreading Excellence and Widening participation (since 2014)

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2019/09/01 - Atual	Medical Microbiology - Coordinator	Biochemistry for Health Master FCT-ITQB-NOVA (Mestrado)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2014/03/01 - 2023	Molecular Basis of Disease Coordinator	Biochemistry for Health Master FCT-ITQB-NOVA (Mestrado)	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2022 - Atual	General Council of UNL Membro	Universidade Nova de Lisboa, Portugal
2020 - Atual	Ethical Committee of IHMT-ITQB-Nova-IGC
2019/01/01 - Atual	ITQB representative in NovaPrecision da NovaSaúde working Group. UNL Membro	Universidade Nova de Lisboa, Portugal
2014/01/01 - Atual	Coordinator of Gene Expression and Stress Survival of ITQB MOSTMICRO (Molecular, Structural and Cellular Microbiology ) Unit Coordenador	Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/01/01 - 2023	Coordinator of Chronic Disease and Infection Group of NovaSaúde, UNL Coordenador	Universidade Nova de Lisboa, Portugal
2018 - 2021	General Council Membro	Universidade Nova de Lisboa, Portugal

Distinções

Prémio

2023	Women in Science 2023 Ciência Viva, Portugal