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Francis holds an MSc (2005) in biomedical sciences and a PhD (2010) in the field of mass spectrometry-based proteomics, both obtained at Ghent University. He then moved to the Pasteur Institute in Paris for a 4-year postdoc where he applied his proteomics expertise to study bacterial infection by the foodborne model pathogen Listeria monocytogenes. In 2015 Francis moved back to Belgium to lead the Proteomics Core at VIB-UGent and in 2016 he started his own research group supported by an Odysseus starting grant. His research aims to better understand the fundamental principles of bacteria-host interactions and to develop novel antimicrobial approaches. Francis is a VIB group leader since 2016 and an Associate Professor at Ghent University since 2018. His current projects focus on the development of novel antibacterial nanobodies and mRNA vaccines and in 2023 he was awarded an ERC Consolidator Grant to investigate rare diseases triggered by infection. So far his research resulted in 110 publications listen in Pubmed (h-index of 37).
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Identificação

Identificação pessoal

Nome completo
Impens Francis

Nomes de citação

  • Francis, Impens

Identificadores de autor

Ciência ID
8317-A175-8EED
ORCID iD
0000-0003-2886-9616

Endereços de correio eletrónico

  • francis.impens@ugent.be (Profissional)

Telefones

Telefone
  • (+32) 9 224 98 3 (Profissional)

Moradas

  • Technologiepark-Zwijnaarde 75, 9052, Zwijnaarde, Gent, Bélgica (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Holandês (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2010/05/19
Concluído
 Doctor in Biomedical Sciences (Doctor of Philosophy)
Universiteit Gent, Bélgica
2005/07/08
Concluído
 Biomedical Sciences (Master)
Universiteit Gent, Bélgica
"Proteomics-based characterization of the effects of taxol on adherent human type II lung carcinoma cells" (TESE/DISSERTAÇÃO)
 Greatest Distinction
2003/07/10
Concluído
 Biomedical Sciences (Bachelor)
Universiteit Gent, Bélgica
 Greatest Distinction
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/10/01 - Atual Investigador principal (carreira) (Investigação) Universiteit Gent, Bélgica
Department of Biomolecular Medicine, Bélgica
2016/10/01 - Atual Investigador principal (carreira) (Investigação) Vlaams Instituut voor Biotechnologie, Bélgica
VIB UGent Centrum voor Medische Biotechnologie, Bélgica
2015/10/01 - Atual Investigador Coordenador (carreira) (Investigação) Vlaams Instituut voor Biotechnologie, Bélgica
VIB Proteomics Core, Bélgica
Projetos

Bolsa

Designação Financiadores
2014/01 - Atual Molecular and therapeutic aspects of proteolytic machineries in immune cells for cardiac inflammation.
254158365
 Deutsche Forschungsgemeinschaft
2023/08 - 2028/07 ERC Consolidator Grant: Multi-omics characterization of immune triggers in Moyamoya disease
101089193
 European Research Council
2023/07 - 2028/06 EU Horizon 2020 Action Grant: Immunopeptidomics-based development of next-generation bacterial mRNA vaccines
101080544
 Horizon 2020
2024/01 - 2027/12 SBO Project: Biochemical identification of virus susceptibility factors for crop improvement and sustainable cultivation
S000624N
 Fonds de la Recherche Scientific
2022/12 - 2026/11 UGent Starting Grant: Vaccine-induced and ISG15-mediated immune responses to Bacterial Infection and Moyamoya Disease
BOF/STA/202209/011
 Universiteit Gent
2021/01 - 2024/12 UGent Concerted Research Action (BOF-GOA) Grant: Proteomics-derived epitopes for dramatically improved anticancer and antimicrobial vaccine development
BOF21/GOA/033
 Universiteit Gent
2019/01 - 2022/12 EPIC-XS consortium: European Proteomics Infrastructure Consortium providing Access
823839
 Horizon 2020
2019/04 - 2022/03 ERA-Net E-Rare Grant ReCognitION: Recognition and Validation of Druggable Targets from the Response to Cognitive Behaviour Therapy in Myotonic Dystrophy type 1 patients from Integrated -Omics Networks
18-038
 Horizon 2020
2016/10 - 2021/09 Proteomics-based characterization of the protein interplay between pathogenic bacteria and their host
G0F8616N
 Fonds Wetenschappelijk Onderzoek Vlaanderen
2017/06 - 2021/05 Integrated platform to validate vesicular trafficking-associated processes in neurodegenerative diseases
Neuro-TRAFFIC
 Fonds Wetenschappelijk Onderzoek Vlaanderen
2017/04 - 2020/03 The Interferon Stimulated Gene 15 (ISG15) modification system in host pathogen interactions: Mechanisms, technology and translational potential
BacVirISG15
 European Commission
Produções

Publicações

Artigo em revista
  1. Janssens, Arne; Nguyen, Van Son; Cecil, Adam J; Van der Verren, Sander E; Evy Timmerman; Deghelt, Michaël; Pak, Alexander J; et al. "SlyB encapsulates outer membrane proteins in stress-induced lipid nanodomains". NATURE (2024): {35-{35. https://biblio.ugent.be/publication/01HM8KSXTZHBGDJ6T6X3A6FZ3B.
    10.1038/s41586-023-06925-5
  2. Debaugnies, M; Rodríguez-Acebes, S; Blondeau, J; Parent, MA; Zocco, M; Song, Y; de Maertelaer, V; et al. "RHOJ controls EMT-associated resistance to chemotherapy". NATURE {616 (2023): {168-175. https://biblio.ugent.be/publication/01H63DN1T31XZA6G285HZY4B8C.
    10.1038/s41586-023-05838-7
  3. Sheryazdanova, A; Amoedo, ND; Sara Dufour; Francis Impens; Rossignol, R; Sablina, A. "The deubiquitinase OTUB1 governs lung cancer cell fitness by modulating proteostasis of OXPHOS proteins". BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE {1869 {7 (2023): {11-{11. https://biblio.ugent.be/publication/01H63GEXBK1YWKDPJYR77ZGCZN.
    10.1016/j.bbadis.2023.166767
  4. Myrsini Sakarika; Frederiek-Maarten Kerckhof; Lotte Van Peteghem; Pinto Martins Pereira, Alexandra; Tim Van Den Bossche; Robbin Bouwmeester; Ralf Gabriels; et al. "The nutritional composition and cell size of microbial biomass for food applications are defined by the growth conditions". MICROBIAL CELL FACTORIES {22 {1 (2023): {15-{15. https://biblio.ugent.be/publication/01HM8MYX68X94NR63VST693TXT.
    10.1186/s12934-023-02265-1
  5. Ormancey, M; Guillotin, B; Merret, R; Camborde, L; Duboé, C; Fabre, B; Pouzet, C; et al. "Complementary peptides represent a credible alternative to agrochemicals by activating translation of targeted proteins". NATURE COMMUNICATIONS {14 {1 (2023): {13-{13. https://biblio.ugent.be/publication/01GQJQNR5HQW5AZE3XBQ0YPX42.
    10.1038/s41467-023-35951-0
  6. Adriaenssens, E; Asselbergh, B; Rivera-Mejías, P; Bervoets, S; Vendredy, L; De Winter, V; Spaas, K; et al. "Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space". NATURE CELL BIOLOGY {25 (2023): {467-480. https://biblio.ugent.be/publication/01GQJR3XXZ7Q3PD2PX6Z6HF1DD.
    10.1038/s41556-022-01074-9
  7. Bansaccal, Nordin; Vieugue, Pauline; Sarate, Rahul; Song, Yura; Minguijon, Esmeralda; Miroshnikova, Yekaterina A; Zeuschner, Dagmar; et al. "The extracellular matrix dictates regional competence for tumour initiation". NATURE {623 {7988 (2023): {828-835. https://biblio.ugent.be/publication/01HM8KE3EWKSB5SKQNFWD5EGHM.
    10.1038/s41586-023-06740-y
  8. Sewduth, Raj N; Carai, Paolo; Ivanisevic, Tonci; Zhang, Mingzhen; Jang, Hyunbum; Lechat, Benoit; Delphi Van Haver; et al. "Spatial mechano-signaling regulation of GTPases through non-degradative ubiquitination". ADVANCED SCIENCE {10 {36 (2023): {12-{12. https://biblio.ugent.be/publication/01HFBNAT99230MSX07XEHS7DW9.
    10.1002/advs.202303367
  9. Schuermans, Nika; El Chehadeh, Salima; Dimitri Hemelsoet; Gautheron, Jérémie; Vantyghem, Marie-Christine; Nouioua, Sonia; Tazir, Meriem; et al. "Loss of phospholipase PLAAT3 causes a mixed lipodystrophic and neurological syndrome due to impaired PPAR¿ signaling". NATURE GENETICS {55 {11 (2023): {1929-1940. https://biblio.ugent.be/publication/01HFBMQ61SGP3NC5AVXFJDXFGF.
    10.1038/s41588-023-01535-3
  10. Tušar, Livija; Loboda, Jure; Francis Impens; Sosnowski, Piotr; Emmy Van Quickelberghe; Vidmar, Robert; Demol, Hans; et al. "Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins". COMMUNICATIONS BIOLOGY {6 {1 (2023): {15-{15. https://biblio.ugent.be/publication/01GYWZ37GRKCSWKPDJG8D4GBGE.
    10.1038/s42003-023-04772-8
  11. Lore Billiet; De Cock, Laurenz; Sanchez Sanchez, Guillem; Rupert Laurenz Mayer; Goetgeluk, Glenn; Stijn De Munter; Pille, Melissa; et al. "Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage". JOURNAL OF EXPERIMENTAL MEDICINE {220 {6 (2023): {30-{30. https://biblio.ugent.be/publication/01GYYXFX77KJ2AKMCZYSM8WVV3.
    10.1084/jem.20220942
  12. Benjamin CAPPE; Vadi, Mike; Sack, Eliza; Wacheul, Ludivine; Bruno Verstraeten; Sara Dufour; Franck, Julien; et al. "Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis". JOURNAL OF EXTRACELLULAR VESICLES {12 {10 (2023): {20-{20. https://biblio.ugent.be/publication/01HFBM7SM4CXCJG8WJBZ2M7GN6.
    10.1002/jev2.12365
  13. Jingjing Huang; An Staes; Francis Impens; Demichev, Vadim; Frank Van Breusegem; Kris Gevaert; Patrick Willems. "CysQuant : simultaneous quantification of cysteine oxidation and protein abundance using data dependent or independent acquisition mass spectrometry". REDOX BIOLOGY {67 (2023): {11-{11. https://biblio.ugent.be/publication/01HCCD64KTD5J6512R2VZ4Y5MN.
    10.1016/j.redox.2023.102908
  14. Guo, W; Wang, H; Kumar Tharkeshwar, A; Couthouis, J; Braems, E; Masrori, P; Van Schoor, E; et al. "CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity". ALZHEIMERS & DEMENTIA {19 {4 (2023): {1245-1259. https://biblio.ugent.be/publication/8764285.
    10.1002/alz.12760
  15. Sara Alves; Joana M. Pereira; Rupert Laurenz Mayer; Alexandre Gonçalves; Francis Impens; Didier Cabanes; Sandra Sousa. "Cells Responding to Closely Related Cholesterol-Dependent Cytolysins Release Extracellular Vesicles with a Common Proteomic Content Including Membrane Repair Proteins". Toxins (2022): https://www.mdpi.com/2072-6651/15/1/4.
    10.3390/toxins15010004
  16. "A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A.". The FEBS journal (2022): https://doi.org/10.1111/febs.16368.
    10.1111/febs.16368
  17. Asselman, Caroline; Dimitri Hemelsoet; Denzel Eggermont; Bart Dermaut; Francis Impens. "Moyamoya disease emerging as an immune-related angiopathy". TRENDS IN MOLECULAR MEDICINE {28 {11 (2022): {939-950. https://biblio.ugent.be/publication/8768234.
    10.1016/j.molmed.2022.08.009
  18. Petracchini, S; Hamaoui, D; Doye, A; Asnacios, A; Fage, F; Vitiello, E; Balland, M; et al. "Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division". NATURE COMMUNICATIONS {13 {1 (2022): {22-{22. https://biblio.ugent.be/publication/8770648.
    10.1038/s41467-022-33803-x
  19. Rupert Laurenz Mayer; Rein Verbeke; Asselman, Caroline; ilke aernout; Gul, Adillah; Denzel Eggermont; Boucher, Katie; et al. "Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes". NATURE COMMUNICATIONS {13 {1 (2022): {17-{17. https://biblio.ugent.be/publication/8770650.
    10.1038/s41467-022-33721-y
  20. Qing Lu; Zhang, Yonghong; Hellner, Joakim; Giannini, Caterina; xiangyu xu; Pauwels, Jarne; Qian Ma; et al. "Proteome-wide cellular thermal shift assay reveals unexpected cross-talk between brassinosteroid and auxin signaling". Proceedings of the National Academy of Sciences of the USA {119 {11 (2022): {e2118220119-{e2118220119. https://biblio.ugent.be/publication/8745667.
    10.1073/pnas.2118220119
  21. Van Royen, Tessa; Sedeyn, Koen; Moschonas, Georgios; Toussaint, Wendy; Vuylsteke, M; Delphi Van Haver; Francis Impens; et al. "An unexpected encounter : respiratory syncytial virus nonstructural protein 1 interacts with mediator subunit MED25". JOURNAL OF VIROLOGY {96 {19 (2022): {20-{20. https://biblio.ugent.be/publication/8768230.
    10.1128/jvi.01297-22
  22. "The Final Maturation State of ß-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.". Journal of molecular biology (2021): https://doi.org/10.1016/j.jmb.2021.167397.
    10.1016/j.jmb.2021.167397
  23. "Proteome Profiling of RNF213 Depleted Cells Reveals Nitric Oxide Regulator DDAH1 Antilisterial Activity.". Frontiers in cellular and infection microbiology (2021): https://europepmc.org/articles/PMC8595287.
    10.3389/fcimb.2021.735416
  24. "Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials.". Cytotherapy (2021): https://doi.org/10.1016/j.jcyt.2021.08.005.
    10.1016/j.jcyt.2021.08.005
  25. "Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection.". Nature immunology (2021): https://doi.org/10.1038/s41590-021-01035-8.
    10.1038/s41590-021-01035-8
  26. "Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity.". Nature communications (2021): https://doi.org/10.1038/s41467-021-26061-w.
    10.1038/s41467-021-26061-w
  27. "Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across clinical conditions.". Journal of extracellular vesicles (2021): https://europepmc.org/articles/PMC8363909.
    10.1002/jev2.12122
  28. "Proteomics Mapping of the ISGylation Landscape in Innate Immunity.". Frontiers in immunology (2021): https://europepmc.org/articles/PMC8383068.
    10.3389/fimmu.2021.720765
  29. "Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.". Cancer research (2021): https://doi.org/10.1158/0008-5472.CAN-20-3669.
    10.1158/0008-5472.can-20-3669
  30. "Immunopeptidomics for next-generation bacterial vaccine development.". Trends in microbiology (2021): https://doi.org/10.1016/j.tim.2021.04.010.
    10.1016/j.tim.2021.04.010
  31. "Quality standards in proteomics research facilities: Common standards and quality procedures are essential for proteomics facilities and their users.". EMBO reports (2021): https://doi.org/10.15252/embr.202152626.
    10.15252/embr.202152626
  32. "Identification of the MuRF1 Skeletal Muscle Ubiquitylome Through Quantitative Proteomics.". Function (Oxford, England) (2021): https://europepmc.org/articles/PMC8218097.
    10.1093/function/zqab029
  33. "Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency.". Circulation research (2021): https://europepmc.org/articles/PMC8048381.
    10.1161/circresaha.120.316966
  34. "The mitotic checkpoint is a targetable vulnerability of carboplatin-resistant triple negative breast cancers.". Scientific reports (2021): https://europepmc.org/articles/PMC7862668.
    10.1038/s41598-021-82780-6
  35. "Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis.". Nature (2020): https://doi.org/10.1038/s41586-020-03046-1.
    10.1038/s41586-020-03046-1
  36. "ATP13A3 is a major component of the enigmatic mammalian polyamine transport system.". The Journal of biological chemistry (2020): https://europepmc.org/articles/PMC7948421.
    10.1074/jbc.ra120.013908
  37. Tom van der Meer; Arno Verlee; Patrick Willems; Francis Impens; Kris Gevaert; Christa Testerink; Christian V. Stevens; Frank Van Breusegem; Pavel Kerchev. "Chemical Genetics Approach Identifies Abnormal Inflorescence Meristem 1 as a Putative Target of a Novel Sulfonamide That Protects Catalase2-Deficient Arabidopsis against Photorespiratory Stress". Cells (2020): https://www.mdpi.com/2073-4409/9/9/2026.
    10.3390/cells9092026
  38. "Establishment of Proximity-Dependent Biotinylation Approaches in Different Plant Model Systems.". The Plant cell (2020): https://doi.org/10.1105/tpc.20.00235.
    10.1105/tpc.20.00235
  39. "Integrator restrains paraspeckles assembly by promoting isoform switching of the lncRNA NEAT1.". Science advances (2020): https://europepmc.org/articles/PMC7455494.
    10.1126/sciadv.aaz9072
  40. "Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3.". Nucleic acids research (2020): https://europepmc.org/articles/PMC7229811.
    10.1093/nar/gkaa280
  41. "Three decades of listeriology through the prism of technological advances.". Cellular microbiology (2020): https://doi.org/10.1111/cmi.13183.
    10.1111/cmi.13183
  42. "Simple Peptide Quantification Approach for MS-Based Proteomics Quality Control.". ACS omega (2020): https://europepmc.org/articles/PMC7114614.
    10.1021/acsomega.0c00080
  43. "The Noonan Syndrome Gene Lztr1 Controls Cardiovascular Function by Regulating Vesicular Trafficking.". Circulation research (2020): https://doi.org/10.1161/CIRCRESAHA.119.315730.
    10.1161/circresaha.119.315730
  44. "Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming.". Science advances (2020): https://europepmc.org/articles/PMC7065878.
    10.1126/sciadv.aay1109
  45. "An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates.". Cancer cell (2020): https://doi.org/10.1016/j.ccell.2020.03.002.
    10.1016/j.ccell.2020.03.002
  46. "Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins.". Scientific reports (2020): https://europepmc.org/articles/PMC7010746.
    10.1038/s41598-020-58397-6
  47. "Removing the Hidden Data Dependency of DIA with Predicted Spectral Libraries.". Proteomics (2020): https://doi.org/10.1002/pmic.201900306.
    10.1002/pmic.201900306
  48. "Environmental conditions steer phenotypic switching in acute hepatopancreatic necrosis disease-causing Vibrio parahaemolyticus, affecting PirAVP /PirBVP toxins production.". Environmental microbiology (2020): https://doi.org/10.1111/1462-2920.14903.
    10.1111/1462-2920.14903
  49. "Ubiquitination of Listeria Virulence Factor InlC Contributes to the Host Response to Infection.". mBio (2019): https://europepmc.org/articles/PMC6918085.
    10.1128/mbio.02778-19
  50. "The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection.". Nature communications (2019): https://europepmc.org/articles/PMC6879477.
    10.1038/s41467-019-13393-x
  51. "The generation and use of recombinant extracellular vesicles as biological reference material.". Nature communications (2019): https://europepmc.org/articles/PMC6650486.
    10.1038/s41467-019-11182-0
  52. "Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection.". Scientific reports (2019): https://europepmc.org/articles/PMC6423322.
    10.1038/s41598-019-41305-y
  53. "Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase.". Nature plants (2019): https://doi.org/10.1038/s41477-019-0378-z.
    10.1038/s41477-019-0378-z
  54. "PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome.". Proceedings of the National Academy of Sciences of the United States of America (2018): https://europepmc.org/articles/PMC6320509.
    10.1073/pnas.1811938116
  55. "Update on the moFF Algorithm for Label-Free Quantitative Proteomics.". Journal of proteome research (2018): https://doi.org/10.1021/acs.jproteome.8b00708.
    10.1021/acs.jproteome.8b00708
  56. "The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages.". Autophagy (2018): https://europepmc.org/articles/PMC6984772.
    10.1080/15548627.2018.1495681
  57. "N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in Saccharomyces cerevisiae.". Molecular & cellular proteomics : MCP (2018): https://europepmc.org/articles/PMC6283290.
    10.1074/mcp.ra118.000982
  58. "Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.". Cell metabolism (2018): https://europepmc.org/articles/PMC8057116.
    10.1016/j.cmet.2018.07.019
  59. "Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.". The Journal of clinical investigation (2018): https://europepmc.org/articles/PMC6063488.
    10.1172/jci96636
  60. "Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature.". Molecular & cellular proteomics : MCP (2018): https://europepmc.org/articles/PMC6126388.
    10.1074/mcp.ra118.000824
  61. "Quantitative proteomics and systems analysis of cultured H9C2 cardiomyoblasts during differentiation over time supports a 'function follows form' model of differentiation.". Molecular omics (2018): https://doi.org/10.1039/c8mo00036k.
    10.1039/c8mo00036k
  62. "Rapid Remodeling of the Host Epithelial Cell Proteome by the Listeriolysin O (LLO) Pore-forming Toxin.". Molecular & cellular proteomics : MCP (2018): https://europepmc.org/articles/PMC6072537.
    10.1074/mcp.ra118.000767
  63. "GSyellow, a Multifaceted Tag for Functional Protein Analysis in Monocot and Dicot Plants.". Plant physiology (2018): https://doi.org/10.1104/pp.18.00175.
    10.1104/pp.18.00175
  64. "Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.". Cell reports (2018): https://europepmc.org/articles/PMC5946459.
    10.1016/j.celrep.2018.03.116
  65. "NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.". Proceedings of the National Academy of Sciences of the United States of America (2018): https://europepmc.org/articles/PMC5924898.
    10.1073/pnas.1718336115
  66. "Quality control in mass spectrometry-based proteomics.". Mass spectrometry reviews (2017): https://doi.org/10.1002/mas.21544.
    10.1002/mas.21544
  67. "Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages.". Cell host & microbe (2017): https://doi.org/10.1016/j.chom.2017.07.020.
    10.1016/j.chom.2017.07.020
  68. "Mapping proteolytic processing in the secretome of gastric cancer-associated myofibroblasts reveals activation of MMP-1, MMP-2, and MMP-3.". Journal of proteome research (2013): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23705892/?tool=EBI.
    10.1021/pr400270q
  69. "The Online Protein Processing Resource (TOPPR): a database and analysis platform for protein processing events.". Nucleic acids research (2012): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23093603/?tool=EBI.
    10.1093/nar/gks998
Capítulo de livro
  1. Delphi Van Haver; Amélie Dendooven; Francis Impens. "Proteomics-based analysis and diagnosis of formalin-fixed paraffin-embedded amyloidosis samples". {213-233. Bélgica: {Springer, 2023.
    10.1007/978-1-0716-3457-8_12
  2. Zhicheng Zhang; Evy Timmerman; Francis Impens; Frank Van Breusegem; M'Hamdi, Amna. "Characterization of RBPome in oxidative stress conditions". editado por {M'Hamdi, Amna, {259-275. Bélgica, 2022.
    10.1007/978-1-0716-2469-2_19
  3. Fernández, Esperanza; Bogaert, Annelies; Evy Timmerman; An Staes; Francis Impens; Kris Gevaert; Devaux, Frédéric. "A strong cation exchange chromatography protocol for examining N-terminal proteoforms". editado por {Devaux, Frédéric, {293-309. Bélgica: {Humana, 2022.
    10.1007/978-1-0716-2257-5_17
Resumo em conferência
  1. Zhicheng Zhang; Evy Timmerman; Francis Impens; Frank Van Breusegem. "Characterization of the Arabidopsis RBPome in oxidative stress conditions". 2022.
    10.1016/j.freeradbiomed.2022.06.217

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Outra produção
  1. How tech-savvy employees make the difference in core facilities : recognizing core facility expertise with dedicated career tracks. 2022. Saskia Lippens; Dominique Audenaert; Alexander Botzki; Derveaux, Stefaan; Ghesquière, Bart; Goeminne, Geert; Hassanzadeh, Reza; et al. https://biblio.ugent.be/publication/8763506.
    10.15252/embr.202255094
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/05/11 Immunopeptidomics for next-generation bacterial vaccine development EPIC-XS Annual Meeting
EPIC-XS Proteomics Consortium (Heraklion, Crete, Grécia)
2023/04/28 Moyamoya emerging as an immune-related angiopathy International Pediatric Stroke Organization (IPSO) 2023 Virtual Conference
International Pediatric Stroke Organization (IPSO)
2022/09/26 Sensing ISGylated proteins Ubiquitomics: Contemporary Understanding
Oxford University (Oxford, Reino Unido)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2016 - Atual Number of PhD students: 5 ongoing, first 2 will defend in 2022
Orientador
Universiteit Gent, Bélgica
2016 - Atual Number of Master thesis students: 4 finished (incl. 1 Erasmus+), 3 ongoing
Orientador
Universiteit Gent, Bélgica

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2017 Member of eight PhD examination Committees, Faculty of Medicine and Health Sciences & Faculty of Pharmaceutical Sciences, UGent, one at Hong Kong University (invited by Prof. Sumana Sanyal) and one at Utrecht University (invited by Prof. Albert Heck)
Arguente
 Member of eight PhD examination Committees (Doutoramento)
2016 Annual member of Master thesis evaluation Committees, Faculty of Medicine and Health Sciences, UGent.
Arguente
 Annual member of Master thesis evaluation Committees (Mestrado)
Universiteit Gent, Bélgica

Arbitragem científica em conferência

Nome da conferência Local da conferência
2022/06/01 - 2022/06/04 The ISG15 system in molecular function and disease mechanisms EMBO Workshop
2022/05/30 - 2022/05/31 Next-Generation Protein Analysis and Detection, 4th edition VIB Conference
2022/05/03 - 2022/05/04 Belgian Proteomics Association (BePA) meeting BePA
2019/12/02 - 2019/12/03 Next-Generation Protein Analysis and Detection, 3rd edition VIB Conference
2018/12/06 - 2018/12/07 Belgian Proteomics Association (BePA) meeting BePA
2018/07/01 - 2018/07/04 Core Technologies for Life Sciences (CTLS) meeting CTLS@VIB

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2022 - Atual Member of the Review Committee of the EMBL Core Facilities, Heidelberg, Germany
Avaliador
2018 - Atual Member of the Scientific Advisory Board of the VIB Metabolomics Core, Ghent, Belgium
Avaliador
 VIB Metabolomics Core, Bélgica

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2018 - 2021 Member of the Superior Health Council Workgroup on “State of "omics" technologies and their clinical applicability”, Belgium Hoge Gezondheidsraad, Bélgica

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019 - Atual Lecturer – Chemical Biology, partim Proteomics, 1st Master in Chemistry, Ghent University, Belgium. (10 lectures/academic year) (Master) Universiteit Gent, Bélgica

Membro de associação

Nome da associação Tipo de participação
2018 - Atual Belgian Proteomics Association (BePA) Board Member
2018 - Atual Core Technologies for Life Sciences (CTLS) Association Member
2015 - Atual Core for Life Member of the Proteomics Working Group

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2018 - Atual Reviewer for grant submitted to ETH Zürich, Switzerland

Revisão ad hoc de artigos em revista

Nome da revista (ISSN) Editora
2019 - Atual Nature Communications
2018 - Atual Molecular and Cellular Proteomics
2015 - Atual Journal of Proteome Research
Distinções

Prémio

2013 1st poster prize, MaxQuant Summer School, Max Planck Institute of Biochemistry, Germany
Max-Planck-Gesellschaft Forschungsservice, Alemanha
2005 Devgen prize for best student in Biomedical Sciences, Ghent University
Universiteit Gent, Bélgica

Outra distinção

2023 ERC Consolidator Grant
European Research Council, Bélgica
2016 Odysseus type II starting grant of the Fund for Scientific Research (FWO), Flanders, Belgium
Fonds Wetenschappelijk Onderzoek Vlaanderen, Bélgica
2014 Postdoctoral Fellowship of the Pasteur-Roux Foundation, France
Institut Pasteur, França
2010 Postdoctoral Fellowship of the Fund for Scientific Research (FWO), Flanders, Belgium
Fonds Wetenschappelijk Onderzoek Vlaanderen, Bélgica
2005 Ph.D. Fellowship of the Fund for Scientific Research (FWO), Flanders
Fonds Wetenschappelijk Onderzoek Vlaanderen, Bélgica