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ACADEMIC: Diana Jurk is Biology of Aging PhD from Newcastle University. | GOUP LEADER OF BIOLOGY OF AGING AND AGE-RELATED DISEASES FROM MAYO CLINIC: investigating the aging and age-related diseases and has made important contributions to the fields of liver disease and neurodegeneration. Additionally, Dr. Jurk was the first to demonstrate that clearance of senescent cells in aged, obese or diabetic mice can alleviate hepatic steatosis, suggesting that elimination of senescent cells can be a novel therapeutic strategy against nonalcoholic fatty liver disease. In the field of neurodegeneration, Dr. Jurk was the first to identify that during aging, post-mitotic neurons acquire a senescent-like phenotype, a phenomenon driven by telomere dysfunction. As part of her independent research program, Dr. Jurk investigated further the role of cellular senescence in the brain in the context of obesity. Her team was the first to demonstrate that senescent cells inhibit neurogenesis, contributing to obesity-induced anxiety-like behavior. This led to the novel concept that senolytic drugs are a potential new therapeutic avenue for treating neuropsychiatric disorders, such as anxiety and depression. SUCCESSFUL SUPERVISION: 6PhD Thesis, 2 Master Thesis; 6 Summer Student; | ON GOING SUPERVISION: 2 PhD students, 3 Master Thesis, 2 Pos-docs and 4 Research Fellow. | PUBLICATIONS: scopus 43 publications, h-index 26 (scopus); 4361 Total Citations (without self-citations); Google Scholar: 53 publications, h-index 28; 6048 citations; | TOP PUBLICATIONS: NATURE MEDICINE (1). NATURE COMMUNICATIONS (7), CELL (1), CELL METABOLISM (2), AGING CELL (9), EMBO JOURNAL (4), AGING (1), CELL SENESCENCE (1), AUTOPHAGY (1). FUNDED PROJECTS: principal investigator of 7 funded projects.
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Identificação

Identificação pessoal

Nome completo
Diana Jurk

Identificadores de autor

Ciência ID
8410-7DF0-DD78
ORCID iD
0000-0003-4486-0857
Formação
Grau Classificação
2007/10/01 - 2012/02/01
Concluído
 Biology of Ageing (Doktor (PhD))
Newcastle University, Reino Unido
1997 - 2004
Concluído
 Naturwissenschaftler (Licence)
Technische Universität Bergakademie Freiberg, Alemanha
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/11/19 - Atual Investigador principal (carreira) (Investigação) Mayo Clinic Department of Physiology and Biomedical Engineering, Estados Unidos
2018 - 2018 Investigador principal (carreira) (Investigação) The Academy of Medical Sciences, UK, Reino Unido
2015 - 2018 Investigador principal (carreira) (Investigação) Newcastle University Faculty of Medical Sciences, Reino Unido

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2019 - Atual Professor Auxiliar (Docente Universitário) Mayo Clinic College of Medicine and Science, Estados Unidos
2019 - Atual Leitor (Docente Universitário) Mayo Clinic Department of Physiology and Biomedical Engineering, Estados Unidos
2019 - Atual Leitor (Docente Universitário) Neurology Monday Grand Rounds, Estados Unidos
2017 - Atual Leitor (Docente Universitário) Newcastle University, Reino Unido
2016 - Atual Leitor (Docente Universitário) MIA-Teaming Summer School on Ageing: From Cell to Society Alvor,, Portugal
2016 - Atual Leitor (Docente Universitário) Newcastle University, Reino Unido
2015 - Atual Leitor (Docente Universitário) Institute Away Day Newcastle Upon Tyne, United Kingdom, Reino Unido
2017 - 2017 Professor Visitante (Docente Universitário) Mayo Clinic Minnesota, Estados Unidos
2016 - 2016 Professor Visitante (Docente Universitário) Mayo Clinic Minnesota, Estados Unidos
2015 - 2015 Professor Visitante (Docente Universitário) Mayo Clinic Minnesota, Estados Unidos

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2021 - Atual New Physician & Scientist - Leadership Launch: Building Your Career at Mayo Clinic Mayo Clinic Minnesota, Estados Unidos
2019 - Atual Associate Consultant II-Research Department of Physiology and Biomedical Engineering, Rochester, Minnesota, Estados Unidos
Mayo Clinic Minnesota, Estados Unidos
2019 - Atual Associate Consultant II-Research (Joint Appointment) - Department of Neurology, Mayo Clinic, Rochester, Minnesota, Estados Unidos
Mayo Clinic Minnesota, Estados Unidos
2019 - Atual Full Faculty Privileges in Neuroscience Mayo Clinic College of Medicine and Science, Estados Unidos
2019 - Atual New Physician & Scientist - Professionalism & Values II Mayo Clinic Minnesota, Estados Unidos
2019 - Atual New Physician & Scientist - Leading with Emotional Intelligence Mayo Clinic Rochester, Estados Unidos
2018 - 2021 Associate Consultant I-Research (Joint Appointment) - Department of Neurology, Mayo Clinic, Rochester, Minnesota, Estados Unidos
Mayo Clinic Minnesota, Estados Unidos
2018 - 2021 Associate Consultant I-Research Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, Estados Unidos
Mayo Clinic Minnesota, Estados Unidos
2020 - 2020 Maximizing Mentorship Mayo Clinic Minnesota, Estados Unidos
2012 - 2015 Research Associate Newcastle University Institute for Ageing and Health, Reino Unido
Newcastle University, Reino Unido
Projetos

Bolsa

Designação Financiadores
2020/09 - 2025/05 Does obesity exacerbate age-related cognitive decline via senescence?
R01AG06818201
 National Institute on Aging
2020 - 2025 The role of sub-lethal mitochondrial apoptotic stress in cellular senescence.
R01 AG 68048
Co-investigator
Em curso
2019 - 2024 C-SiG Pilot and Feasibility Program (Jurk). Funded by National Institute of Diabetes and Digestive and Kidney Diseases
P30 DK 84567
Investigador responsável
Em curso
2020 - 2022 Investigating the mechanisms mediating lipid accumulation in the aging liver. Funded by Ted Nash Long Life Foundation.
NA
Investigador responsável
Concluído
2020/06 - 2021/07 Investigate the mechanisms mediating lipid accumulation in senescent cells in the liver
P30 DK 84567
 National Institute of Diabetes and Digestive and Kidney Diseases
2020/08 - 2021/02 Targeting Cellular Senescence to Extend Healthspan
R01AG 62413-02S1
 National Institute on Aging
2016/09 - 2020/09 Investigation of mechanisms underlying cellular senescence and the Senescence-associated secretory phenotype (SASP) during brain ageing
1813970
 Biotechnology and Biological Sciences Research Council
2016 - 2020 Kogod Center on Aging - 004
NA
Co-investigator
2018/03 - 2018/12 How does cell senescence impact on the ageing brain?
None-SBF003\1179
 Academy of Medical Sciences

Outro

Designação Financiadores
2016 - 2017 Do surviving dopaminergic neurons in Parkinson disease develop a senescent phenotype?
BH154188
Investigador responsável
Produções

Publicações

Artigo em revista
  1. Jurk, Diana. "Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.". The EMBO journal (2021): https://doi.org/10.15252/embj.2020106048.
    10.15252/embj.2020106048
  2. Huber G; Ogrodnik M; Wenzel J; Stölting I; Huber L; Will O; Peschke E; et al. "Telmisartan prevents high-fat diet-induced neurovascular impairments and reduces anxiety-like behavior.". Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2021): http://europepmc.org/abstract/med/33730932.
    10.1177/0271678x211003497
  3. Jurk, Diana. "Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis". Journal of immunology (Baltimore, Md. : 1950) (2021): https://doi.org/10.4049/jimmunol.2001022.
    10.4049/jimmunol.2001022
  4. Jurk, Diana. "Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice". Aging cell (2021): https://doi.org/10.1111/acel.13296.
    10.1111/acel.13296
  5. Jurk, Diana. "Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span". Annual review of pharmacology and toxicology (2021): https://europepmc.org/articles/PMC7790861.
    10.1146/annurev-pharmtox-050120-105018
  6. Edward Fielder; Clare Tweedy; Caroline Wilson; Fiona Oakley; Fiona E. N. LeBeau; João F. Passos; Derek A. Mann; Thomas Zglinicki; Diana Jurk. "Anti-inflammatory treatment rescues memory deficits during aging in nfkb1 -/- mice". Aging Cell 19 10 (2020): https://doi.org/10.1111/acel.13188.
    10.1111/acel.13188
  7. Jurk, Diana. "Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence". Genes & Development (2020): http://dx.doi.org/10.1101/gad.331272.119.
    10.1101/gad.331272.119
  8. Jurk, Diana. "Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk". Nature Communications (2020): http://dx.doi.org/10.1038/s41467-019-14187-x.
    10.1038/s41467-019-14187-x
  9. Jurk, Diana. "Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition.". Aging cell (2019): https://doi.org/10.1111/acel.13079.
    10.1111/acel.13079
  10. Jurk, Diana. "Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction.". The EMBO journal (2019): https://doi.org/10.15252/embj.2019101982.
    10.15252/embj.2019101982
  11. Jurk, Diana. "Cellular Senescence: Defining a Path Forward.". Cell (2019): https://doi.org/10.1016/j.cell.2019.10.005.
    10.1016/j.cell.2019.10.005
  12. Jurk, Diana. "Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence". Trends in Biochemical Sciences (2019): http://dx.doi.org/10.1016/j.tibs.2019.06.011.
    10.1016/j.tibs.2019.06.011
  13. Jurk, Diana. "Targeting senescent cells alleviates obesity-induced metabolic dysfunction". Aging Cell (2019): http://dx.doi.org/10.1111/acel.12950.
    10.1111/acel.12950
  14. Anderson R; Lagnado A; Maggiorani D; Walaszczyk A; Dookun E; Chapman J; Birch J; et al. "Length-independent telomere damage drives post-mitotic cardiomyocyte senescence.". The EMBO journal (2019): http://europepmc.org/abstract/med/30737259.
    10.15252/embj.2018100492
  15. Ogrodnik M; Zhu Y; Langhi LGP; Tchkonia T; Krüger P; Fielder E; Victorelli S; et al. "Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.". Cell metabolism (2019): http://europepmc.org/abstract/med/30612898.
    10.1016/j.cmet.2018.12.008
  16. Correia-Melo C; Birch J; Fielder E; Rahmatika D; Taylor J; Chapman J; Lagnado A; et al. "Rapamycin improves healthspan but not inflammaging in nf¿b1-/- mice.". Aging cell (2018): http://europepmc.org/abstract/med/30468013.
    10.1111/acel.12882
  17. Tiniakos D; Jurk D. "A novel Sudan Black B-based analogue revives lipofuscin as a biomarker for in vivo senescence.". Virchows Archiv : an international journal of pathology (2018): http://europepmc.org/abstract/med/30225657.
    10.1007/s00428-018-2452-8
  18. Xu M; Pirtskhalava T; Farr JN; Weigand BM; Palmer AK; Weivoda MM; Inman CL; et al. "Senolytics improve physical function and increase lifespan in old age.". Nature medicine (2018): http://europepmc.org/abstract/med/29988130.
    10.1038/s41591-018-0092-9
  19. Tarragó MG; Chini CCS; Kanamori KS; Warner GM; Caride A; de Oliveira GC; Rud M; et al. "A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.". Cell metabolism (2018): http://europepmc.org/abstract/med/29719225.
    10.1016/j.cmet.2018.03.016
  20. Carroll B; Otten EG; Manni D; Stefanatos R; Menzies FM; Smith GR; Jurk D; et al. "Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.". Nature communications (2018): http://europepmc.org/abstract/med/29343728.
    10.1038/s41467-017-02746-z
  21. Ogrodnik M; Jurk D. "Senescence explains age- and obesity-related liver steatosis.". Cell stress (2017): http://europepmc.org/abstract/med/31225436.
    10.15698/cst2017.10.108
  22. Jurk, Diana. "Cellular senescence drives age-dependent hepatic steatosis.". Nature Communications (2017): http://europepmc.org/abstract/med/28608850.
    10.1038/ncomms15691
  23. Jurk, Diana. "The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?". Journal of Alzheimer's disease : JAD (2017): http://europepmc.org/abstract/med/28436392.
    10.3233/jad-161221
  24. Stout MB; Steyn FJ; Jurczak MJ; Camporez JG; Zhu Y; Hawse JR; Jurk D; et al. "17a-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization.". (2017): http://europepmc.org/abstract/med/26809497.
  25. Hewitt G; Carroll B; Sarallah R; Correia-Melo C; Ogrodnik M; Nelson G; Otten EG; et al. "SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.". (2016): http://europepmc.org/abstract/med/27391408.
  26. Roos CM; Zhang B; Palmer AK; Ogrodnik MB; Pirtskhalava T; Thalji NM; Hagler M; et al. "Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.". (2016): http://europepmc.org/abstract/med/26864908.
    10.1111/acel.12458
  27. Xu M; Bradley EW; Weivoda MM; Hwang SM; Pirtskhalava T; Decklever T; Curran GL; et al. "Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.". (2016): http://europepmc.org/abstract/med/27516624.
  28. Correia-Melo C; Marques FD; Anderson R; Hewitt G; Hewitt R; Cole J; Carroll BM; et al. "Mitochondria are required for pro-ageing features of the senescent phenotype.". (2016): http://europepmc.org/abstract/med/26848154.
    10.15252/embj.201592862
  29. Speakman JR; Blount JD; Bronikowski AM; Buffenstein R; Isaksson C; Kirkwood TB; Monaghan P; et al. "Oxidative stress and life histories: unresolved issues and current needs.". (2015): http://europepmc.org/abstract/med/26811750.
    10.1002/ece3.1790
  30. Birch J; Anderson RK; Correia-Melo C; Jurk D; Hewitt G; Marques FM; Green NJ; et al. "DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.". (2015): http://europepmc.org/abstract/med/26386121.
    10.1152/ajplung.00293.2015
  31. Jurk, Diana. "Corrigendum: NF¿B1 is a suppressor of neutrophil-driven hepatocellular carcinoma.". Nature Communications (2015): http://europepmc.org/abstract/med/26387912.
    10.1038/ncomms9411
  32. Wilson CL; Jurk D; Fullard N; Banks P; Page A; Luli S; Elsharkawy AM; et al. "NF¿B1 is a suppressor of neutrophil-driven hepatocellular carcinoma.". (2015): http://europepmc.org/abstract/med/25879839.
    10.1038/ncomms7818
  33. Jurk, D.; Wilson, C.; Passos, J.F.; Oakley, F.; Correia-Melo, C.; Greaves, L.; Saretzki, G.; et al. "Chronic inflammation induces telomere dysfunction and accelerates ageing in mice". Nature Communications 2 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84903485542&partnerID=MN8TOARS.
    10.1038/ncomms5172
  34. Correia-Melo, C.; Jurk, D.; Passos, J.F.. "Robust multiparametric assessment of cellular senescence.". Methods in molecular biology (Clifton, N.J.) 965 (2013): 409-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878852895&partnerID=MN8TOARS.
    10.1007/978-1-62703-239-1_27
  35. Jurk, D.; Wang, C.; Miwa, S.; Maddick, M.; Korolchuk, V.; Tsolou, A.; Gonos, E.S.; et al. "Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response". Aging Cell 11 6 (2012): 996-1004. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869186918&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2012.00870.x
  36. Nelson, G.; Wordsworth, J.; Wang, C.; Jurk, D.; Lawless, C.; Martin-Ruiz, C.; von Zglinicki, T.. "A senescent cell bystander effect: Senescence-induced senescence". Aging Cell 11 2 (2012): 345-349. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862794254&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2012.00795.x
  37. Verma, S.; Tachtatzis, P.; Penrhyn-Lowe, S.; Scarpini, C.; Jurk, D.; Von Zglinicki, T.; Coleman, N.; Alexander, G.J.M.. "Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver". Hepatology 56 4 (2012): 1510-1520. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867206636&partnerID=MN8TOARS.
    10.1002/hep.25787
  38. Lawless, C.; Jurk, D.; Gillespie, C.S.; Shanley, D.; Saretzki, G.; von Zglinicki, T.; Passos, J.F.. "A stochastic step model of replicative senescence explains ROS production rate in ageing cell populations". PLoS ONE 7 2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857134740&partnerID=MN8TOARS.
    10.1371/journal.pone.0032117
  39. Hewitt, G.; Jurk, D.; Marques, F.D.M.; Correia-Melo, C.; Hardy, T.; Gackowska, A.; Anderson, R.; et al. "Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence". Nature Communications 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859352385&partnerID=MN8TOARS.
    10.1038/ncomms1708
  40. Wang C; Maddick M; Miwa S; Jurk D; Czapiewski R; Saretzki G; Langie SA; et al. "Adult-onset, short-term dietary restriction reduces cell senescence in mice.". (2010): http://europepmc.org/abstract/med/20844316.
  41. Lawless, C.; Wang, C.; Jurk, D.; Merz, A.; Zglinicki, T.V.; Passos, J.F.. "Quantitative assessment of markers for cell senescence". Experimental Gerontology 45 10 (2010): 772-778. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956988624&partnerID=MN8TOARS.
    10.1016/j.exger.2010.01.018
  42. Wang, C.; Jurk, D.; Maddick, M.; Nelson, G.; Martin-ruiz, C.; Von Zglinicki, T.. "DNA damage response and cellular senescence in tissues of aging mice". Aging Cell 8 3 (2009): 311-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-66149167336&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2009.00481.x
Capítulo de livro
  1. Correia-Melo, Clara; Jurk, Diana; Passos, João F.. "Robust Multiparametric Assessment of Cellular Senescence". In Methods in Molecular Biology, 409-419. Humana Press, 2012.
    10.1007/978-1-62703-239-1_27
Poster em conferência
  1. Jurk, Diana. "Role of fibrosis and senescence in ageing mice liver". Trabalho apresentado em Role of fibrosis and senescence in ageing mice liver, 2019.
  2. Jurk, Diana. "Cellular senescence drives age-dependent hepatic steatosis". Trabalho apresentado em 8th Alliance for Healthy Aging Symposium, 2017.
  3. Jurk, Diana. "Chronic inflammation induces telomere dysfunction, limits regenerative capacity, and accelerates ageing in mice". Trabalho apresentado em 5th Alliance for Healthy Aging Symposium, 2014.
  4. Jurk, Diana. "Chronic inflammation induces telomere dysfunction, limits regenerative capacity, and accelerates aging in mice". Trabalho apresentado em 4th Alliance for Healthy Aging Symposium, Molecular Mechanisms of Age-Related Multi Morbidity, 2013.
  5. Jurk, Diana. "Persistent pro-inflammatory signalling accelerates ageing". Trabalho apresentado em Gordon Research Conference on Aging, Biology, 2012.
  6. Jurk, Diana. "Pro-inflammatory signalling in nfkb1-/- mice impairs tissue homeostasis and accelerates ageing via aggravation of cell senescence". Trabalho apresentado em 3rd Alliance for Healthy Aging Symposium, 2012.
  7. Jurk, Diana. "Persistent pro-inflammatory signalling accelerates ageing". Trabalho apresentado em BSRA Annual Scientific Meeting, The Science of Ageing – Global Progress, 2011.
  8. Jurk, Diana. "Involvement of p50 in a positive feedback loop between ROS and DNA damage response during senescence". Trabalho apresentado em BSRA Annual Scientific Meeting, systems biology of ageing, 2010.
  9. Jurk, Diana. "Role of NF-kB transcription factor p50 in cellular senescence and possible consequences for in vivo ageing". Trabalho apresentado em Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, 2010.

Propriedade Intelectual

Patente
  1. Jurk, Diana. 2018. "Methods and materials for treating neuropsychiatric disorders". Estados Unidos.

Outros

Outra produção
  1. Temporal inhibition of autophagy reveals segmental reversal of aging with increased cancer risk: Supplemental Move 1. 2019. Cassidy L; Young AR; Young CN; Soilleux EJ; Fielder E; Weigand BM; Brais R; et al. http://europepmc.org/abstract/PPR/PPR68230.
    10.1101/528984
  2. Length-independent telomere damage drives cardiomyocyte senescence. 2018. Anderson R; Lagnado A; Maggiorani D; Walaszczyk A; Dookun E; Chapman J; Birch J; et al. http://europepmc.org/abstract/PPR/PPR47459.
    10.1101/394809
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021 Cellular ageing as a driver of metabolic health and psychiatric symptoms Chronic Disease and Mental Health - Nature Conferences
2020 Basic concepts of cellular senescence: its role in aging and liver disease AASLD-liver meeting
2020 My career journey - All roads lead to Rome Annual Retreat of EIT Health Ageing PhD School
2019 Cellular senescence: key driver of brain aging and anxiety Ageing: models, mechanisms and therapies
2019 Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis Redox Signalling in physiology, ageing and disease (BSRA & Biochemical Society)
2019 Senolytics: a potential new therapeutic avenue for treating neuropsychiatric disorders? disorders? NTS Satellite Symposium SfN 2019: “Induction and resolution of neuroinflammation and neurotoxicity."
2019 Cellular Senescence: key driver of brain aging and anxiety 10th Annual Alliance for Healthy Aging Conference
2017 Cellular senescence drives age-dependent hepatic steatosis International Cell Senescence Association (ICSA) Conference 2017
2014 Chronic inflammation accelerates mouse aging RANK Prize Funds symposia: Oxidative Stress, Does it Play a Role in Life Histories and Ageing?
2014 Inflammation and senescence drivers of accelerated ageing CIMA Scientific Meeting ‘Nutrition and Musculoskeletal Ageing- opportunities for intervention
2013 Chronic inflammation accelerates mouse aging Cold Spring Harbor Asia Conferences: New Advances in Optical Imaging of Live Cells and Organisms
2012 Persistent pro-inflammatory signalling accelerates ageing Ageing and Basic Bioscience Conference
2010 Cellular senescence in ageing mice: Do telomeres play a role? Swedish Telomere and Telomerase Network Meeting
2010 Role of NF-kB transcription factor p50 in cellular senescence and possible consequences for in vivo ageing Biology of Aging (GRS), Gordon-Kenan Research Seminar
2009 Cellular Senescence in Aging Mice: Focus on gut and liver 38th Annual Meeting of the American Aging Association
2008 Role of fibrosis and senescence in ageing mice liver BSRA, 58th Annual Scientific Meeting 'Ageing: Molecules to Man

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - Atual NA
Orientador
2021 - Atual NA
Orientador
2021 - Atual NA
Orientador
2021 - Atual NA
Orientador
2021 - Atual NA
Coorientador
2021 - Atual Predoctoral Fellow
Orientador
2021 - Atual Postdoctoral Fellow
Orientador
2020 - Atual NA
Orientador
2020 - Atual NA
Orientador
2020 - Atual NA
Orientador
2020 - Atual Research Fellow
Orientador
2018 - Atual Research Fellow
Orientador
2020 - 2022 Graduate Research Employment Program (GREP) Student
Orientador
2017 - 2021 NA
Orientador
2017 - 2021 NA
Orientador
2016 - 2021 NA
Orientador
2018 - 2020 Postdoctoral Fellow
Orientador
2019 - 2019 NA
Orientador
2014 - 2018 NA
Orientador
2013 - 2018 NA
Orientador
2013 - 2018 NA
Orientador
2013 - 2017 NA
Orientador
2015 - 2016 The Role of mtDNA Mutations in Telomere-Induced Senescence
Orientador

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2021 - Atual Metabolism
2021 - Atual Nature Communications
2021 - Atual Nature Med
2021 - Atual Nature Metabolism
2020 - Atual Aging Cell
2020 - Atual Cell Metabolism
2020 - Atual Cell Reports
2020 - Atual Genes
2020 - Atual iScience
2020 - Atual Cells

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019 - Atual Cellular Senescence: A Driver of Aging and Liver Disease

Membro de associação

Nome da associação Tipo de participação
2019 - Atual 10th Annual Alliance for Healthy Aging Conference Program Director
2019 - Atual American Aging Association Scientist Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021 - Atual Chronic Disease and Mental Health - Nature Conferences
Presidente / Vice-presidente
2019 - Atual Member of International Cell Senescence Association
Membro
2019 - Atual Society for Neuroscience
Membro
2019 - Atual Gerontological Society of America
Outro
2019 - Atual Chronic Disease and Mental Health - Nature Conferences
2019 - Atual American Aging Association
Membro
2017 - Atual Institute Away Day Conference
Presidente / Vice-presidente
2019 - 2021 Gerontological Society of America
Outro

Tutoria

Tópico Nome do aluno
2017 - Atual Mentor of the Research Fellows Anthony Lagnado
2017 - 2017 Patrick Krueger
2013 - 2013 Alexander Neumann
2011 - 2012 Clemens Joos
2010 - 2010 Arthur Fischbach
Distinções

Prémio

2016 Travel Award for 7th Annual Alliance for Healthy Aging Conference
Mayo Clinic Minnesota, Estados Unidos
2014 Travel Award for 5th Annual Alliance for Healthy Aging Conference
Mayo Clinic Minnesota, Estados Unidos
2013 Travel Award for: Molecular Basis of Aging and Disease conference
Dushu Lake Conference Center, China
2012 Travel Award for 3rd Annual Alliance for Healthy Aging Conference -
Mayo Clinic Minnesota, Estados Unidos
2008 Best talk prize at 58th Annual Scientific Meeting: Molecules to Man

Outra distinção

2009 UK representative at the 38th annual conference of AGE -
American Aging Association, Estados Unidos