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Ph.D (1997) Norwegian University of Science and Technology, Trondheim, Norway. Postdoctoral studies at the Research Institute for Plant Protection, DLO, Wageningen, The Netherlands (2 years), and the Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, USA (3 years). Sabbatical stay at the Department of Ecology & Evolutionary biology, Yale University, New Haven, in 2011. Tenured faculty in the Department of Pharmacy, the University of Tromsø, and full professor since 2005. Leader of the research group on microbiology, molecular- and pharmacoepidemiology 2009-2014. Head of Department of Life Science and Health, Oslo Metropolitan University, Oslo, Sept 2014-April 2020. Vice-dean of Innovation, Faculty of health sciences, OsloMet (April 2020-). Research focus is on understanding how bacteria utilize horizontally transferred foreign DNA (Thomas and Nielsen, 2005, Nature Rev. Microbiol 3, 711-21), and the factors that regulate genetic recombination process in natural environments (Nielsen and Townsend, 2004, Nature Biotechnol. 22, 1110-4, Overballe-Pettersen et al. 2013. PNAS 49, 19860-65) and probe the stringency of barriers towards interspecies transfers of antimicrobial resistance determinants (Ray et al. 2009, Genetics, 182, 1165-81); including those residing on mobile genetic elements (Domingues et al., 2012, PLoS Pathogens 8, e1002837, Starikova et al., 2012, PLoS Pathogens 8: e10030439. We also seek to better understand the fate of HGT events in bacterial populations over time (Townsend et al., 2012. Front. Microbiol. 3, 27., Nielsen et al. 2014. Front. Microbiol. 4, 415). The research group in Tromsø hosted visiting researchers from Austria, Germany, USA, Italy, Taiwan, Turkey, India, Portugal, Denmark, UK, Russia, and New Zealand and was evaluated as ¿excellent¿ by the Research Council of Norway (NFR) in 2006 (ISBN82-12-02383-4). An additional research interest has been the potential for unintended horizontal dissemination of antibiotic resistance marker genes used in GMOs and their broader societal impact (Nielsen, 2013, PloS Biology 11, e1001499). As part of the latter research I have participated in biosafety capacity building activities in all regions of the world, including Genok, FAO and WHO organized events. I was an advisor to Genok-Center for Biosafety (www.genok.org) until 2017, and have been a member of the GMO Panel of the Norwegian Food Safety Committee 2007-2017 (www.vkm.no). Am since 2018 a member of the Microbial ecology panel. Appointed expert member of the GMO panel of the European Food Safety Authority 2009-2015 (www.efsa.eu). Since 2000, I have been invited for oral presentations all over the world. Finally, I have contributed extensively with peer review services of scientists, publications and proposals, including services for research councils in France, Germany, Italy, Poland, UK, USA, and the ERC, Europe. For the latter I was the chair of one of the StG LS9 panels.
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Identificação

Identificação pessoal

Nome completo
Kaare Magne Nielsen

Nomes de citação

  • Nielsen, Kaare

Identificadores de autor

Ciência ID
841D-A7B2-6A08
ORCID iD
0000-0002-7217-2114

Telefones

Telemóvel
  • (+47) 95722588 (Pessoal)

Moradas

  • Oslo Metropolitan University, PO Box, 4 St Olavs Plass, 0130, Oslo, Oslo, Noruega (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Microbiologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Norueguês (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
1997
Concluído
 Microbiology/genetics (Doctor of Philosophy)
Norges Teknisk Naturvitenskapelige Universitet Institutt for biologi, Noruega
1993
Concluído
 Molecular Biology (Master)
Norges Teknisk Naturvitenskapelige Universitet Institutt for biologi, Noruega
1991
Concluído
 Chemistry (Bachelor)
Norges Teknisk Naturvitenskapelige Universitet Institutt for biologi, Noruega
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2014 - Atual Professor Catedrático (Docente Universitário) Oslo Metropolitan University - Fakultet for helsevitenskap, Noruega
2005 - 2014 Professor Catedrático (Docente Universitário) UiT Norges arktiske universitet, Noruega
2001 - 2005 Professor Associado (Docente Universitário) UiT Norges arktiske universitet, Noruega

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/04 - Atual Subdirector de Unidade Orgânica Oslo Metropolitan University - Fakultet for helsevitenskap, Noruega
2018 - Atual Expert member Microbial Ecology panel Vitenskapskomiteen for mattrygghet, Noruega
2017 - Atual Editorial Board of Microorganisms Multidisciplinary Digital Publishing Institute AG, Suiça
2007 - 2018 Expert member GMO panel Vitenskapskomiteen for mattrygghet, Noruega
2015 - 2017 Chair of the HOV research programme OsloMet - storbyuniversitetet, Noruega
2009 - 2015 Expert member on GMO panel European Food Safety Authority, Itália
2006 - 2006 Expert member Food and Agriculture Organization of the United Nations, Itália

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2014 - 2020/04 Head of Department of Life Sciences and Health Oslo Metropolitan University - Fakultet for helsevitenskap, Noruega
2002 - 2017 Scientific advisor GenØk Senter for biosikkerhet, Noruega
2008 - 2014 Head of section/leader of thematic research group UiT Norges arktiske universitet, Noruega
Projetos

Bolsa

Designação Financiadores
2012 - 2013 Prevalence of clinically troublesome antibiotic resistance traits in severely polluted freshwater channels in Northern China
NFR 219858
Orientador
Concluído
2012 - 2013 The fitness cost of antimicrobial resistance: a bacterial perspective
YGGDRASIL 219856
Orientador
Concluído
2011 - 2012 Unravelling novel mechanisms of horizontal transfer of integrons in bacteria: implications for the dissemination of antibiotic resistance
YGGDRASIL 195862/V11
Orientador
Concluído
2011 - 2012 Studies on naturally produced membrane vesicles from Acinetobacter
IS-MOBIL
Orientador
2003 - 2012 Epidemiology of antibiotic resistance in clinical and environmental settings: prevalence, host diversity, and transfer of blaTEM genes
NT-NFR fri prosjektstøtte 157861/V40
Orientador
Concluído
2006 - 2010 Effect of environmental DNA exposure on bacterial adaptation rates
FRIBIO. 172046/V40
Investigador responsável
Concluído
2004 - 2009 Functional genomics of the malaria parasite Plasmodium falciparum
FRIBIO-NFR. 161009
Investigador responsável
Concluído
2003 - 2007 Mutator phenotypes: distribution, population dynamics, and impact on bacterial adaptation and evolution
BIOMOL-NFR 153587
Investigador responsável
Concluído
2003 - 2007 Predicting the fate of transgenes horizontally transferred into bacteria - a population genetics approach
NFR MILJØ 2015.154200
Investigador responsável
Concluído
2001 - 2005 Dynamics, horizontal transfer and selection of engineered DNA in the phytosphere of transgenic and transplastomic plants
NT-NFR Biologisk mangfold 140890
Investigador responsável
Concluído
1998 - 2001 Factors influencing horizontal gene transfer in the environment
NT Biologisk mangfold 121733
Investigador responsável
Concluído
Produções

Publicações

Artigo em revista
  1. Domingues, Sara; Rosário, Natasha; Cândido, Ângela; Neto, Daniela; Nielsen, Kaare; Da Silva, Gabriela. "Competence for Natural Transformation Is Common among Clinical Strains of Resistant Acinetobacter spp.". Microorganisms 7 2 (2019): 30. http://dx.doi.org/10.3390/microorganisms7020030.
    10.3390/microorganisms7020030
  2. Larsson DGJ; Andremont A; Bengtsson-Palme J; Brandt KK; de Roda Husman AM; Fagerstedt P; Fick J; et al. "Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance.". Environment international (2018): http://europepmc.org/abstract/med/29747082.
    10.1016/j.envint.2018.04.041
  3. Domingues, S.; Nielsen, K.M.. "Membrane vesicles and horizontal gene transfer in prokaryotes". Current Opinion in Microbiology 38 (2017): 16-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018497666&partnerID=MN8TOARS.
    10.1016/j.mib.2017.03.012
  4. Borruso, L.; Harms, K.; Johnsen, P.J.; Nielsen, K.M.; Brusetti, L.. "Distribution of class 1 integrons in a highly impacted catchment". Science of the Total Environment 566-567 (2016): 1588-1594. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989872851&partnerID=MN8TOARS.
    10.1016/j.scitotenv.2016.06.054
  5. Harms, K.; Lunnan, A.; Hülter, N.; Mourier, T.; Vinner, L.; Andam, C.P.; Marttinen, P.; et al. "Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms". Proceedings of the National Academy of Sciences of the United States of America 113 52 (2016): 15066-15071. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007506866&partnerID=MN8TOARS.
    10.1073/pnas.1615819114
  6. Utnes AL; Sørum V; Hülter N; Primicerio R; Hegstad J; Kloos J; Nielsen KM; Johnsen PJ. "Growth phase-specific evolutionary benefits of natural transformation in Acinetobacter baylyi.". (2015): http://europepmc.org/abstract/med/25848876.
    10.1038/ismej.2015.35
  7. Woegerbauer M; Zeinzinger J; Gottsberger RA; Pascher K; Hufnagl P; Indra A; Fuchs R; et al. "Antibiotic resistance marker genes as environmental pollutants in GMO-pristine agricultural soils in Austria.". (2015): http://europepmc.org/abstract/med/26232739.
    10.1016/j.envpol.2015.07.028
  8. Domingues S; da Silva GJ; Nielsen KM. "Global dissemination patterns of common gene cassette arrays in class 1 integrons.". (2015): http://europepmc.org/abstract/med/25901001.
    10.1099/mic.0.000099
  9. Woegerbauer M; Kuffner M; Domingues S; Nielsen KM. "Involvement of aph(3')-IIa in the formation of mosaic aminoglycoside resistance genes in natural environments.". (2015): http://europepmc.org/abstract/med/26042098.
    10.3389/fmicb.2015.00442
  10. Fulsundar S; Harms K; Flaten GE; Johnsen PJ; Chopade BA; Nielsen KM. "Gene transfer potential of outer membrane vesicles of Acinetobacter baylyi and effects of stress on vesiculation.". (2014): http://europepmc.org/abstract/med/24657872.
    10.1128/AEM.04248-13
  11. Woegerbauer M; Zeinzinger J; Springer B; Hufnagl P; Indra A; Korschineck I; Hofrichter J; et al. "Prevalence of the aminoglycoside phosphotransferase genes aph(3')-IIIa and aph(3')-IIa in Escherichia coli, Enterococcus faecalis, Enterococcus faecium, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica and Staphylococcus aureus isolates in Austria.". (2014): http://europepmc.org/abstract/med/24194558.
    10.1099/jmm.0.065789-0
  12. Nielsen KM; Bøhn T; Townsend JP. "Detecting rare gene transfer events in bacterial populations.". (2014): http://europepmc.org/abstract/med/24432015.
    10.3389/fmicb.2013.00415
  13. Starikova I; Al-Haroni M; Werner G; Roberts AP; Sørum V; Nielsen KM; Johnsen PJ. "Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis.". (2013): http://europepmc.org/abstract/med/23833178.
    10.1093/jac/dkt270
  14. Overballe-Petersen S; Harms K; Orlando LA; Mayar JV; Rasmussen S; Dahl TW; Rosing MT; et al. "Bacterial natural transformation by highly fragmented and damaged DNA.". (2013): http://europepmc.org/abstract/med/24248361.
    10.1073/pnas.1315278110
  15. Domingues S; Toleman MA; Nielsen KM; da Silva GJ. "Identical miniature inverted repeat transposable elements flank class 1 integrons in clinical isolates of Acinetobacter spp.". (2013): http://europepmc.org/abstract/med/23596242.
    10.1128/JCM.00692-13
  16. Nielsen KM. "Biosafety data as confidential business information.". (2013): http://europepmc.org/abstract/med/23472051.
    10.1371/journal.pbio.1001499
  17. Aguilera, J.; Nielsen, K.M.; Sweet, J.. "Risk assessment of GM trees in the EU: Current regulatory framework and guidance". IForest 6 1 (2013): 127-131. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877774809&partnerID=MN8TOARS.
    10.3832/ifor0101-006
  18. Podevin N; Devos Y; Davies HV; Nielsen KM. "Transgenic or not? No simple answer! New biotechnology-based plant breeding techniques and the regulatory landscape.". (2012): http://europepmc.org/abstract/med/23154464.
    10.1038/embor.2012.168
  19. Domingues S; Nielsen KM; da Silva GJ. "Various pathways leading to the acquisition of antibiotic resistance by natural transformation.". (2012): http://europepmc.org/abstract/med/23482877.
    10.4161/mge.23089
  20. Domingues S; da Silva GJ; Nielsen KM. "Integrons: Vehicles and pathways for horizontal dissemination in bacteria.". (2012): http://europepmc.org/abstract/med/23550063.
    10.4161/mge.22967
  21. Rizzi A; Raddadi N; Sorlini C; Nordgrd L; Nielsen KM; Daffonchio D. "The stability and degradation of dietary DNA in the gastrointestinal tract of mammals: implications for horizontal gene transfer and the biosafety of GMOs.". (2012): http://europepmc.org/abstract/med/22059960.
    10.1080/10408398.2010.499480
  22. Starikova I; Harms K; Haugen P; Lunde TT; Primicerio R; Samuelsen Ø; Nielsen KM; Johnsen PJ. "A trade-off between the fitness cost of functional integrases and long-term stability of integrons.". (2012): http://europepmc.org/abstract/med/23209414.
    10.1371/journal.ppat.1003043
  23. Tekle YI; Nielsen KM; Liu J; Pettigrew MM; Meyers LA; Galvani AP; Townsend JP. "Controlling antimicrobial resistance through targeted, vaccine-induced replacement of strains.". (2012): http://europepmc.org/abstract/med/23227198.
    10.1371/journal.pone.0050688
  24. Domingues S; Harms K; Fricke WF; Johnsen PJ; da Silva GJ; Nielsen KM. "Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species.". (2012): http://europepmc.org/abstract/med/22876180.
    10.1371/journal.ppat.1002837
  25. Townsend JP; Bøhn T; Nielsen KM. "Assessing the probability of detection of horizontal gene transfer events in bacterial populations.". (2012): http://europepmc.org/abstract/med/22363321.
    10.3389/fmicb.2012.00027
  26. Fladung, M.; Altosaar, I.; Bartsch, D.; Baucher, M.; Boscaleri, F.; Gallardo, F.; Häggman, H.; et al. "European discussion forum on transgenic tree biosafety". Nature Biotechnology 30 1 (2012): 37-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855522633&partnerID=MN8TOARS.
    10.1038/nbt.2078
  27. Nordgård, L.; Brusetti, L.; Raddadi, N.; Traavik, T.; Averhoff, B.; Nielsen, K.M.; Nordg?rd, L.; et al. "An investigation of horizontal transfer of feed introduced DNA to the aerobic microbiota of the gastrointestinal tract of rats.". BMC research notes 5 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874405038&partnerID=MN8TOARS.
    10.1186/1756-0500-5-170
  28. Domingues S; Nielsen KM; da Silva GJ. "The blaIMP-5-carrying integron in a clinical Acinetobacter baumannii strain is flanked by miniature inverted-repeat transposable elements (MITEs).". (2011): http://europepmc.org/abstract/med/21810834.
    10.1093/jac/dkr327
  29. Johnsen PJ; Townsend JP; Bøhn T; Simonsen GS; Sundsfjord A; Nielsen KM. "Retrospective evidence for a biological cost of vancomycin resistance determinants in the absence of glycopeptide selective pressures.". (2011): http://europepmc.org/abstract/med/21217128.
    10.1093/jac/dkq512
  30. Sletvold H; Johnsen PJ; Wikmark OG; Simonsen GS; Sundsfjord A; Nielsen KM. "Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages.". (2010): http://europepmc.org/abstract/med/20558469.
    10.1093/jac/dkq219
  31. Glad T; Kristiansen VF; Nielsen KM; Brusetti L; Wright AD; Sundset MA. "Ecological characterisation of the colonic microbiota in arctic and sub-arctic seals.". (2010): http://europepmc.org/abstract/med/20523986.
    10.1007/s00248-010-9690-x
  32. Moe MK; Samuelsen PJ; Nielsen HV; Nielsen KM. "Separation of DNA-containing organelles from Toxoplasma gondii by CZE.". (2010): http://europepmc.org/abstract/med/20333721.
    10.1002/elps.200900582
  33. Rosvoll TC; Pedersen T; Sletvold H; Johnsen PJ; Sollid JE; Simonsen GS; Jensen LB; Nielsen KM; Sundsfjord A. "PCR-based plasmid typing in Enterococcus faecium strains reveals widely distributed pRE25-, pRUM-, pIP501- and pHTbeta-related replicons associated with glycopeptide resistance and stabilizing toxin-antitoxin systems.". (2010): http://europepmc.org/abstract/med/20015231.
    10.1111/j.1574-695X.2009.00633.x
  34. Glad T; Bernhardsen P; Nielsen KM; Brusetti L; Andersen M; Aars J; Sundset MA. "Bacterial diversity in faeces from polar bear (Ursus maritimus) in Arctic Svalbard.". (2010): http://europepmc.org/abstract/med/20074323.
    10.1186/1471-2180-10-10
  35. Ray JL; Harms K; Wikmark OG; Starikova I; Johnsen PJ; Nielsen KM. "Sexual isolation in Acinetobacter baylyi is locus-specific and varies 10,000-fold over the genome.". (2009): http://europepmc.org/abstract/med/19474200.
    10.1534/genetics.109.103127
  36. Johnsen PJ; Townsend JP; Bøhn T; Simonsen GS; Sundsfjord A; Nielsen KM. "Factors affecting the reversal of antimicrobial-drug resistance.". (2009): http://europepmc.org/abstract/med/19467475.
    10.1016/S1473-3099(09)70105-7
  37. Sletvold H; Johnsen PJ; Hamre I; Simonsen GS; Sundsfjord A; Nielsen KM. "Complete sequence of Enterococcus faecium pVEF3 and the detection of an omega-epsilon-zeta toxin-antitoxin module and an ABC transporter.". (2008): http://europepmc.org/abstract/med/18511120.
    10.1016/j.plasmid.2008.04.002
  38. Rizzi A; Pontiroli A; Brusetti L; Borin S; Sorlini C; Abruzzese A; Sacchi GA; et al. "Strategy for in situ detection of natural transformation-based horizontal gene transfer events.". (2008): http://europepmc.org/abstract/med/18165369.
    10.1128/AEM.02185-07
  39. Rizzi, A.; Brusetti, L.; Arioli, S.; Nielsen, K.M.; Tamagnini, I.; Tamburini, A.; Sorlini, C.; Daffonchio, D.. "Detection of feed-derived maize DNA in goat milk and evaluation of the potential of horizontal transfer to bacteria". European Food Research and Technology 227 6 (2008): 1699-1709. http://www.scopus.com/inward/record.url?eid=2-s2.0-51849125605&partnerID=MN8TOARS.
    10.1007/s00217-008-0896-9
  40. Brusetti, L.; Glad, T.; Borin, S.; Myren, P.; Rizzi, A.; Johnsen, P.J.; Carter, P.; Daffonchio, D.; Nielsen, K.M.. "Low prevalence of blaTEM genes in Arctic environments and agricultural soil and rhizosphere". Microbial Ecology in Health and Disease 20 1 (2008): 27-36. http://www.scopus.com/inward/record.url?eid=2-s2.0-42049095073&partnerID=MN8TOARS.
    10.1080/08910600701838244
  41. Sletvold H; Johnsen PJ; Simonsen GS; Aasnaes B; Sundsfjord A; Nielsen KM. "Comparative DNA analysis of two vanA plasmids from Enterococcus faecium strains isolated from poultry and a poultry farmer in Norway.". (2007): http://europepmc.org/abstract/med/17116680.
    10.1128/AAC.00557-06
  42. Nielsen KM; Johnsen PJ; Bensasson D; Daffonchio D; Nielsen, K.M.; Johnsen, P.J.; Bensasson, D.; Daffonchio, D.. "Release and persistence of extracellular DNA in the environment.". Environmental Biosafety Research 6 1-2 (2007): 37-53. http://europepmc.org/abstract/med/17961479.
    10.1051/ebr:2007031
  43. Ray JL; Andersen HK; Young S; Nielsen KM; O'Callaghan M; Ray, J.L.; Andersen, H.K.; et al. "An assessment of the potential of herbivorous insect gut bacteria to develop competence for natural transformation.". Environmental Biosafety Research 6 1-2 (2007): 135-147. http://europepmc.org/abstract/med/17961487.
    10.1051/ebr:2007032
  44. Nordgård L; Nguyen T; Midtvedt T; Benno Y; Traavik T; Nielsen KM; Nordgård, L.; et al. "Lack of detectable DNA uptake by bacterial gut isolates grown in vitro and by Acinetobacter baylyi colonizing rodents in vivo.". Environmental Biosafety Research 6 1-2 (2007): 149-160. http://europepmc.org/abstract/med/17961488.
    10.1051/ebr:2007029
  45. Aa E; Townsend JP; Adams RI; Nielsen KM; Taylor JW. "Population structure and gene evolution in Saccharomyces cerevisiae.". (2006): http://europepmc.org/abstract/med/16879422.
    10.1111/j.1567-1364.2006.00059.x
  46. Bethke, L.L.; Zilversmit, M.; Nielsen, K.; Daily, J.; Volkman, S.K.; Ndiaye, D.; Lozovsky, E.R.; Hartl, D.L.; Wirth, D.F.. "Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum". Molecular and Biochemical Parasitology 150 1 (2006): 10-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748331115&partnerID=MN8TOARS.
    10.1016/j.molbiopara.2006.06.004
  47. Thomas CM; Nielsen KM. "Mechanisms of, and barriers to, horizontal gene transfer between bacteria.". (2005): http://europepmc.org/abstract/med/16138099.
    10.1038/nrmicro1234
  48. Nordgård L; Traavik T; Nielsen KM. "Nucleic acid isolation from ecological samples--vertebrate gut flora.". (2005): http://europepmc.org/abstract/med/15865959.
    10.1016/S0076-6879(05)95003-9
  49. Ray JL; Nielsen KM. "Experimental methods for assaying natural transformation and inferring horizontal gene transfer.". (2005): http://europepmc.org/abstract/med/15865981.
    10.1016/S0076-6879(05)95026-X
  50. Johnsen, P.J.; Østérhus, J.I.; Sletvold, H.; Sørum, M.; Kruse, H.; Nielsen, K.; Simonsen, G.S.; Sundsfjord, A.. "Persistence of animal and human glycopeptide-resistant enterococci on two Norwegian poultry farms formerly exposed to avoparcin is associated with a widespread plasmid-mediated vanA element within a polyclonal Enterococcus faecium population". Applied and Environmental Microbiology 71 1 (2005): 159-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-12244277629&partnerID=MN8TOARS.
    10.1128/AEM.71.1.159-168.2005
  51. Pettersen AK; Bøhn T; Primicerio R; Shorten PR; Soboleva TK; Nielsen KM; Pettersen, A.-K.; et al. "Modeling suggests frequency estimates are not informative for predicting the long-term effect of horizontal gene transfer in bacteria.". Environmental Biosafety Research 4 4 (2005): 223-233. http://europepmc.org/abstract/med/16827550.
    10.1051/ebr:2006008
  52. Nielsen KM; Townsend JP. "Monitoring and modeling horizontal gene transfer.". (2004): http://europepmc.org/abstract/med/15340481.
    10.1038/nbt1006
  53. Bensasson D; Boore JL; Nielsen KM. "Genes without frontiers?". (2004): http://europepmc.org/abstract/med/15162114.
    10.1038/sj.hdy.6800451
  54. Davison, J.; Heinemann, J.A.; Traavik, T.; Nielsen, K.M.; Townsend, J.. "Monitoring horizontal gene transfer [3] (multiple letters)". Nature Biotechnology 22 11 (2004): 1349-1350. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344237502&partnerID=MN8TOARS.
    10.1038/nbt1104-1349b
  55. Barry AE; Leliwa A; Choi M; Nielsen KM; Hartl DL; Day KP. "DNA sequence artifacts and the estimation of time to the most recent common ancestor (TMRCA) of Plasmodium falciparum.". (2003): http://europepmc.org/abstract/med/12946852.
    10.1016/S0166-6851(03)00164-6
  56. Townsend JP; Nielsen KM; Fisher DS; Hartl DL; Townsend, J.P.; Nielsen, K.M.; Fishert, D.S.; Hartl, D.L.. "Horizontal acquisition of divergent chromosomal DNA in bacteria: effects of mutator phenotypes.". Genetics 164 1 (2003): 13-21. http://europepmc.org/abstract/med/12750317.
  57. Nielsen KM; Kasper J; Choi M; Bedford T; Kristiansen K; Wirth DF; Volkman SK; Lozovsky ER; Hartl DL. "Gene conversion as a source of nucleotide diversity in Plasmodium falciparum.". (2003): http://europepmc.org/abstract/med/12679555.
    10.1093/molbev/msg076
  58. Nielsen KM. "Transgenic organisms--time for conceptual diversification?". (2003): http://europepmc.org/abstract/med/12610561.
    10.1038/nbt0303-227
  59. Townsend, J.P.; Nielsen, K.M.; Fisher, D.S.; Hartl, D.L.. "Erratum: Horizontal acquisition of divergent chromosomal DNA in bacteria: Effects of mutator phenotype (Genetics 164 (13-12))". Genetics 164 3 (2003): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000184487400034&KeyUID=WOS:000184487400034.
  60. Townsend, J.P.; Nielsen, K.M.; Fishert, D.S.; Hartl, D.L.. "Horizontal acquisition of divergent chromosomal DNA in bacteria: Effects of mutator phenotypes". Genetics 164 1 (2003): 13-21. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000183119700003&KeyUID=WOS:000183119700003.
  61. Volkman SK; Hartl DL; Wirth DF; Nielsen KM; Choi M; Batalov S; Zhou Y; et al. "Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum.". (2002): http://europepmc.org/abstract/med/12364807.
    10.1126/science.1075642
  62. Hartl DL; Volkman SK; Nielsen KM; Barry AE; Day KP; Wirth DF; Winzeler EA. "The paradoxical population genetics of Plasmodium falciparum.". (2002): http://europepmc.org/abstract/med/12036741.
    10.1016/S1471-4922(02)02268-7
  63. Volkman SK; Barry AE; Lyons EJ; Nielsen KM; Thomas SM; Choi M; Thakore SS; et al. "Recent origin of Plasmodium falciparum from a single progenitor.". (2001): http://europepmc.org/abstract/med/11463913.
    10.1126/science.1059878
  64. Nielsen, K.M.; Van Elsas, J.D.; Smalla, K.; Nielsen KM; Elsas JDvan; Smalla K. "Dynamics, horizontal transfer and selection of novel DNA in bacterial populations in the phytosphere of transgenic plants". Annals of Microbiology 51 1 (2001): 79-94. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000169625900007&KeyUID=WOS:000169625900007.
  65. Serr, A.; Koenig, B.F.; Heep, M.; Nielsen, K.; Bangsborg, J.M.. "Update on rifampin resistance in the Legionellaceae". Antimicrobial Agents and Chemotherapy 45 7 (2001): 2181-2182. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034951502&partnerID=MN8TOARS.
    10.1128/AAC.45.7.2181-2182.2001
  66. Nielsen KM; van Elsas JD; Smalla K. "Transformation of Acinetobacter sp. strain BD413(pFG4DeltanptII) with transgenic plant DNA in soil microcosms and effects of kanamycin on selection of transformants.". (2000): http://europepmc.org/abstract/med/10698801.
    10.1128/AEM.66.3.1237-1242.2000
  67. Nielsen KM; Smalla K; van Elsas JD. "Natural transformation of Acinetobacter sp. strain BD413 with cell lysates of Acinetobacter sp., Pseudomonas fluorescens, and Burkholderia cepacia in soil microcosms.". (2000): http://europepmc.org/abstract/med/10618225.
    10.1128/AEM.66.1.206-212.2000
  68. Nielsen, K.; Hindersson, P.; Hoiby, N.; Bangsborg, J.M.. "Sequencing of the rpoB gene in Legionella pneumophila and characterization of mutations associated with rifampin resistance in the Legionellaceae". Antimicrobial Agents and Chemotherapy 44 10 (2000): 2679-2683. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033807017&partnerID=MN8TOARS.
    10.1128/AAC.44.10.2679-2683.2000
  69. Nielsen KM; Bones AM; Smalla K; van Elsas JD. "Horizontal gene transfer from transgenic plants to terrestrial bacteria--a rare event?". (1998): http://europepmc.org/abstract/med/9729765.
    10.1016/S0168-6445(98)00009-6
  70. Nielsen, K.M.; Nielsen KM. "Barriers to horizontal gene transfer by natural transformation in soil bacteria". APMIS, Supplement 106 84 (1998): 77-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031796397&partnerID=MN8TOARS.
  71. Nielsen KM; Bones AM; Van Elsas JD. "Induced Natural Transformation of Acinetobacter calcoaceticus in Soil Microcosms.". (1997): http://europepmc.org/abstract/med/16535710.
  72. Nielsen KM; van Weerelt MD; Berg TN; Bones AM; Hagler AN; van Elsas JD. "Natural transformation and availability of transforming DNA to Acinetobacter calcoaceticus in soil microcosms.". (1997): http://europepmc.org/abstract/med/9143126.
  73. Bones, A.M.; Honne, B.I.; Nielsen, K.M.; Visvalingam, S.; Ponnampalam, S.; Winge, P.; Thangstad, O.P.. "Performance of transgenic plants of potato (Solanum tuberosum cv. Laila) grown in vitro in greenhouse and in a field trial". Acta Agriculturae Scandinavica Section B: Soil and Plant Science 47 3 (1997): 156-167. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031419354&partnerID=MN8TOARS.
    10.1080/09064719709362456
  74. Nielsen, K.M.; Bones, A.M.; Van Elsas, J.D.. "Induced natural transformation of Acinetobacter calcoaceticus in soil microcosms". Applied and Environmental Microbiology 63 10 (1997): 3972-3977. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030840441&partnerID=MN8TOARS.
  75. Nielsen, K.M.; Van Weerelt, M.D.M.; Berg, T.N.; Bones, A.M.; Hagler, A.N.; Van Elsas, J.D.. "Natural transformation and availability of transforming DNA to Acinetobacter calcoaceticus in soil microcosms". Applied and Environmental Microbiology 63 5 (1997): 1945-1952. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030898619&partnerID=MN8TOARS.
  76. Odegaard, E.; Nielsen, K.M.; Beisvag, T.; Evjen, K.; Johnsson, A.; Rasmussen, O.; Iversen, T.H.; et al. "Agravitropic behaviour of roots of rapeseed (Brassica napus L.) transformed by Agrobacterium rhizogenes.". Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 4 3 (1997): 5-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031240633&partnerID=MN8TOARS.
  77. Nielsen, K.M.; Bones, A.M.; Van Elsas, J.D.. "Induced natural transformation of Acinetobacter calcoaceticus in soil microcosms". Applied and Environmental Microbiology 63 10 (1997): 3972-3977. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1997XY72300035&KeyUID=WOS:A1997XY72300035.
  78. Nielsen, K.M.; Van Weerelt, M.D.M.; Berg, T.N.; Bones, A.M.; Hagler, A.N.; Van Elsas, J.D.. "Natural transformation and availability of transforming DNA to Acinetobacter calcoaceticus in soil microcosms". Applied and Environmental Microbiology 63 5 (1997): 1945-1952. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1997WX36100048&KeyUID=WOS:A1997WX36100048.
Capítulo de livro
  1. Nielsen, Kaare. "New molecular genetic techniques: regulatory and societal considerations.". In Area-Wide Integrated Pest Management: development and Field Application, editado por Hendricks, J.; Pereira, R.; Vreysen, J.B., 645-654. Florida, Estados Unidos: CRC Press, 2021.
    Publicado
  2. Nielsen, Kaare. "New molecular genetic techniques: regulatory and societal considerations". In Area-wide Management of Insect Pests, Development and Field Application. 2020.
    No prelo
  3. Fulsundar, Shweta; Domingues, Sara; Nielsen, Kaare Magne. "Vesicle-Mediated Gene Transfer in Acinetobacter baumannii". In Acinetobacter baumannii - Methods in Molecular Biology, 87-94. Springer New York, 2019.
    Publicado • 10.1007/978-1-4939-9118-1_9
  4. Magnus Nielsen, Kaare; van Elsas, Jan Dirk. "Horizontal Gene Transfer and Microevolution in Soil". In Modern Soil Microbiology, 105-123. CRC Press, 2019.
    Publicado • 10.1201/9780429059186-7
  5. Domingues, S.; Nielsen, K.M.. "Horizontal Gene Transfer: Uptake of Extracellular DNA by Bacteria¿". In Reference Module in Biomedical Sciences. Elsevier, 2016.
    Publicado • 10.1016/b978-0-12-801238-3.99485-6
  6. Sundset, Monica A.; Glad, Trine; Nielsen, Kaare M.. "Terrestrial Vertebrate Animal Metagenomics, Non-domesticated Ursidae, Bears". In Encyclopedia of Metagenomics, 1-5. Springer Science, 2014.
    Publicado • 10.1007/978-1-4614-6418-1_107-3
  7. Nielsen, Kaare; Ray, J.L.; Johnsen, P.J.. "Horizontal gene transfer: the uptake of extracellular DNA in bacteria". In Topics in Ecological and Environmental Microbiology, 57-66. Reino Unido, 2012.
    Publicado
  8. Nielsen, Kaare; Daffonchio, D.. "Unintended Horizontal Transfer of Recombinant DNA". In TWN Biotechnology & Biosafety Series no. 13. Malásia: TWN, 2010.
    Publicado
  9. Nielsen, Kaare; Ray, J.L.; Johnsen, P.J.. "The natural uptake of extracellular DNA in bacteria". In Encyclopedia of Microbiology, 587-596. Reino Unido: Academic/Elsevier, 2009.
    Publicado
  10. Kallenborn, R.; Fick, J.; Lindberg, R.; Moe, M.; Nielsen, K. M.; Tysklind, M.; Vasskog, T.. "Pharmaceutical Residues in Northern European Environments: Consequences and Perspectives". In Pharmaceuticals in the Environment, 61-74. Alemanha: Springer Verlag, 2008.
    Publicado • 10.1007/978-3-540-74664-5_5
  11. Nielsen, Kaare; Johnsen, P.; Van Elsas, J.D.. "Gene transfer and micro-evolution in soil.". In Modern Soil Microbiology, 55-81. Estados Unidos: CRC Press, 2007.
    Publicado
  12. Nielsen, Kaare; Daffonchio, D.. "Unintended horizontal transfer of recombinant DNA". In Biosafety First: Holistic Approaches to Risk and Uncertainty in Genetic Engineering and Genetically Modified Organisms, 222-237. Noruega: Tapir Academic Press, 2007.
    Publicado
  13. Nielsen, Kaare; Calamai, L.; Pietramellara, G.. "Stabilization of extracellular DNA by transient binding to various soil surfaces". In Soil Biology. Nucleic acids and proteins in soil., 141-157. Heidelberg, Alemanha: Springer Verlag, 2006.
    Publicado
  14. Ray, Jessica L.; Nielsen, Kaare M.. "Experimental Methods for Assaying Natural Transformation and Inferring Horizontal Gene Transfer". In Molecular Evolution: Producing the Biochemical Data, 491-520. Elsevier, 2005.
    Publicado • 10.1016/s0076-6879(05)95026-x
  15. Nordgård, Lise; Traavik, Terje; Nielsen, Kaare M.. "Nucleic Acid Isolation from Ecological Samples—Vertebrate Gut Flora". In Molecular Evolution: Producing the Biochemical Data, 38-48. Elsevier, 2005.
    Publicado • 10.1016/s0076-6879(05)95003-9
  16. Nielsen, Kaare; Ray, J.L.; Van Elsas, J.D.. "Natural transformation in soil: microcosm studies". In Molecular Microbial Ecology Manual, 1069-1080. Países Baixos: Kluwer Academic publishers, 2004.
    Publicado
  17. Nielsen, Kaare. "An assessment of factors affecting the likelihood of horizontal transfer of recombinant plant DNA to bacterial recipients in the soil and rhizosphere". In Collection of Biosafety Reviews, 96-149. Itália, 2003.
    Publicado
  18. Nielsen, Kaare; Townsend, J.P.. "Environmental exposure, horizontal transfer and selection of transgenes in bacterial populations.". In Enhancing biocontrol agents and handling risks. NATO Science Series, 145-158. Amsterdam, Países Baixos: IOS Press, 2001.
    Publicado
Relatório
  1. 2021. Genome editing in food and feed production – implications for risk assessment. Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment. ISBN: 978-82-8259-372-4, ISSN: 2535-4019.
  2. Nielsen, Kaare. 2007. Expert Consultation on the Safety Assessment of Foods Derived from Recombinant-DNA Animals.
  3. Nielsen, Kaare; Berdal, K.G.; Kruse, H.; Sundsfjord, A.; Mikalsen, A.; Yazdankhah, S.; Nes, I.. 2005. An assessment of potential long-term health effects caused by antibiotic resistance marker genes in genetically modified organisms based on antibiotic usage and resistance patterns in Norway, VKM-Report.
Tese / Dissertação
  1. Domingues, Sara Margarida dos Santos. "Unravelling novel mechanisms of horizontal transfer of class I integrons in bacteria. Implications for the dissemination of antibiotic resistance". Doutoramento, 2016. http://hdl.handle.net/10316/31894.

Outros

Outra produção
  1. Genetically modified microbial symbionts as arthropod pest controllers: risk assessment through the European legislations. 2011. Aguilera J; Gomes AR; Nielsen KM. http://europepmc.org/abstract/AGR/IND44598510.
    10.1111/j.1439-0418.2011.01618.x
  2. The 35S CaMV plant virus promoter is active in human enterocyte-like cells. 2006. Myhre MR; Fenton KA; Eggert J; Nielsen KM; Traavik T. http://europepmc.org/abstract/AGR/IND43824510.
    10.1007/s00217-005-0154-3
  3. Stimulatory effects of compounds present in the rhizosphere on natural transformation of Acinetobacter sp. BD413 in soil.. 2001. Nielsen KM; Elsas JDvan. http://europepmc.org/abstract/AGR/IND23221374.
    10.1016/S0038-0717(00)00147-4
  4. Evaluation of possible horizontal gene transfer from transgenic plants to the soil bacterium Acinetobacter calcoaceticus BD413.. 1997. Nielsen KM; Gebhard F; Smalla K; Bones AM; Elsas JDvan. http://europepmc.org/abstract/AGR/IND21234318.
    10.1007/s001220050630
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2021/11/26 Transfer of genetic material through bacterial membrane vesicles EMBO Workshop: Bacterial membrane vesicles: Biogenesis, functions and medical applications
2019 Detecting Rare Gene Transfer Events in Environmental Bacterial Populations Workshop What is antibiotic resistance? The environmental perspective of a global crisis and its relation to human and animal health
Austrian Agency for Health and Food safety (Vienna, Áustria)
2017 Regulatory and Societal Considerations of New Genetic Techniques 3rd FAO/IAEA International conference on Area-Wide management of insect pests: integrating the sterile insect and related nuclear and other techniques
(Vienna, Áustria)

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2013 - 2013 EU Cost Action FP905 training school “Plant genome modification and the regulatory framework for GM plants in Europe” (2013 - 2013)
Outro (Coorganizador)
2013 - 2013 EU Cost Action FP0905 Workshop and MC meeting, Novel technologies in plant breeding (2013 - 2013)
Oficina (workshop) (Coorganizador)
2003 - 2003 The Impact of genetically modified plants (GMPs) on microbial communities. Workshop supported by a grant from the European Science Foundation (2003 - 2003)
Oficina (workshop) (Coorganizador)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2021/11 - Atual Leader of round table in EMBO workshop "Bacterial membrane vesicles: Biogenesis, functions and medical applications"
Oficina (workshop)
 EMBO workshop "Bacterial membrane vesicles: Biogenesis, functions and medical applications

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2019 - Atual Molecular Biology and Evolution (1537-1719) Oxford University Press
2018 - Atual Nature Microbiology (2058-5276) Springer Science and Business Media LLC
2017 - Atual Environment International (0160-4120) Elsevier
2016 - Atual Nature Communications (2041-1723) Springer Science and Business Media LLC
2015 - Atual Journal of Environmental Quality (1537-2537) Wiley (John Wiley & Sons)
2014 - Atual International Journal of Antimicrobial Agents (0924-8579) Elsevier
2014 - Atual The ISME Journal (1751-7370) Springer Science and Business Media LLC
2014 - Atual PLoS ONE (1932-6203) Public Library of Science
2014 - Atual BMC Microbiology (1471-2180) Springer (Biomed Central Ltd.)
2014 - Atual Scientific Reports (2045-2322) Springer Science and Business Media LLC
2013 - Atual Proceedings of the National Academy of Sciences (1091-6490) Proceedings of the National Academy of Sciences
2013 - Atual Nature Nanotechnology (1748-3395) Springer Science and Business Media LLC
2012 - Atual European Food Research and Technology (1438-2385) Springer-Verlag
2011 - Atual Journal of Applied Microbiology (1365-2672) Wiley (Blackwell Publishing)
2011 - Atual Chemosphere (0045-6535) Elsevier
2011 - Atual Applied and Environmental Microbiology (1098-5336) American Society for Microbiology

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2019 - Atual Peer review for research funding/evaluation bodies: Natural Sciences and Engineering Research Council of Canada
Avaliador
2019 - Atual Chair in European Research Council (ERC) Starting Grants, Life Sciences domain, Brussels.
Coordenador
 European Research Council, Bélgica European Research Council
2018 - Atual Peer review for research funding/evaluation bodies: Estonian Research Council
Avaliador
2017 - Atual Peer review for research funding/evaluation bodies: Lithuanian Research Council
Avaliador
2017 - Atual Peer review for research funding/evaluation bodies: National Science Foundation, USA
Avaliador
2016 - Atual Peer review for research funding/evaluation bodies for National Research Foundation, South Africa
Avaliador
2016 - Atual Peer review for research funding/evaluation bodies: Swiss National Science Foundation
Avaliador
2013 - Atual Peer review for research funding/evaluation bodies: French Research Agency.
Avaliador
2013 - Atual Peer review for research funding/evaluation bodies for Austrian Science Fund
Avaliador
2012 - Atual Peer review for research funding/evaluation bodies: German Research Foundation.
Avaliador
2011 - Atual Peer review for research funding/evaluation bodies for European Research Council.
Avaliador
2013 - 2019 Member and chair of the European Research Council LS9 StG panel review board, responsible for evaluation of starting grant applications, including interviews of candidates in Brussels (2013, 2015, 2017, 2019).
Membro
 European Research Council
2018 - 2018 Peer review for research funding/evaluation bodies: Dutch Research Council, NWO
Avaliador
2016 - 2016 Peer review for research funding/evaluation bodies: Irish Res Council
Avaliador
2014 - 2014 Peer review for research funding/evaluation bodies: Czech Research agency
Avaliador
2013 - 2013 Peer review for research funding/evaluation bodies for National Science Center, Poland.
Avaliador

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2021/11 - Atual Member of the poster award committee at EMBO Workshop: Bacterial membrane vesicles: Biogenesis, functions and medical applications
Membro
2019 - Atual Member of European Science Foundation (ESF) College of Expert Reviewers
Membro
 European Science Foundation, França